Page last updated: 2024-08-17

spironolactone and doxazosin

spironolactone has been researched along with doxazosin in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (25.00)29.6817
2010's17 (70.83)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Andricopulo, AD; Moda, TL; Montanari, CA1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Baldó, E; Costa, JA; González, C; Pascual, JM; Pérez-Lahiguera, F; Rodilla, E1
Barrios, V; Escobar, C1
Brown, MJ; Caulfield, MJ; Cruickshank, JK; Ford, I; MacDonald, TM; Mackenzie, I; McInnes, G; Morant, S; Padmanabhan, S; Salsbury, J; Sever, P; Webb, DJ; Williams, B1
Bakris, GL; Sternlicht, H1
Huynh, K1
Widimský, J1
Rosenberg, M; Stephens, E1
Divisón Garrote, JA; Escobar Cervantes, C1
Boutari, C; Doumas, M; Imprialos, K; Karagiannis, A; Stavropoulos, K1
Douma, S; Gavriilaki, E; Gkaliagkousi, E; Triantafyllou, A1
Dale, A; Goldacre, B; Hartley, P1
Brown, MJ; MacDonald, TM; Morant, SV; Williams, B1
Kaysin, A; Mounsey, A1
Allan, GM; Garrison, S; Turgeon, R1
Casagrande, ML; Cruickshank, JK; Faconti, L; Govoni, V; Mills, CE; Morant, SV; Webb, AJ1
Brown, MJ; Caulfield, MJ; Cruickshank, JK; Ford, I; MacDonald, TM; Mackenzie, IS; McInnes, GT; Morant, SV; Padmanabhan, S; Salsbury, J; Sever, P; Webb, DJ; Williams, B1
Abu-Abeid, S; Aizpuru, A; Arriaga, S; Baranska, M; Barba de la Rosa, AP; Bunce, M; Carothers, MA; Casas-Flores, S; Costantino, M; Cruickshank, JK; Czamara, K; Drzayich Antol, D; Eldar, SM; Esquivel-González, S; Faconti, L; Gamble, DA; Gao, D; Gómez-Hernández, N; Govoni, V; Gu, H; Guo, J; Hanaoka, H; Haruyama, H; Hazzan, D; Hopson, S; Hua, H; Iso, T; Ji, M; Jiang, B; Kaczor, A; Karnas, E; Khoury, R; Kong, F; Kou, Y; Kurabayashi, M; Lahat, G; Li, X; Liang, X; Lin, J; Liu, S; Liu, X; Majka, Z; Matsui, H; Matsui, M; Meves, JM; Michael, T; Mills, CE; Morant, S; Nachmani, I; Negishi, K; Nevo, N; Niu, L; Palomo-Briones, R; Pan, W; Parikh, A; Peterson, ME; Putri, M; Renda, A; Rishniw, M; Shao, CH; Stein, A; Stemkowski, S; Sun, H; Sun, X; Sunaga, H; Syamsunarno, MRAA; Tanaka, R; Tang, R; Tu, J; Umbarawan, Y; Waldman Casebeer, A; Wang, W; Wang, X; Wang, XY; Wang, Y; Webb, AJ; Wojcik, T; Wu, YJ; Xia, X; Xie, D; Xue, M; Yamaguchi, A; Yang, Y; Ying, HM; Yokoyama, T; Zhan, LX; Zhang, B; Zhang, L; Zhang, Q; Zhang, Y; Zhong, Y; Zhou, F; Zuba-Surma, EK; Zuo, D1
Doumas, M; Imprialos, KP; Kallistratos, MS; Manolis, AJ1

Reviews

3 review(s) available for spironolactone and doxazosin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Three drugs and still hypertensive: what's left?
    Canadian family physician Medecin de famille canadien, 2016, Volume: 62, Issue:11

    Topics: Antihypertensive Agents; Bisoprolol; Blood Pressure; Doxazosin; Drug Therapy, Combination; Humans; Hypertension; Potassium; Spironolactone

2016
Recent advances in understanding and managing resistant/refractory hypertension.
    F1000Research, 2020, Volume: 9

    Topics: Antihypertensive Agents; Bisoprolol; Catheters; Clinical Trials as Topic; Clonidine; Denervation; Doxazosin; Humans; Hypertension; Kidney; Spironolactone

2020

Trials

5 trial(s) available for spironolactone and doxazosin

ArticleYear
Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial.
    Lancet (London, England), 2015, Nov-21, Volume: 386, Issue:10008

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-1 Receptor Antagonists; Aged; Bisoprolol; Cross-Over Studies; Double-Blind Method; Doxazosin; Female; Humans; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Spironolactone; Treatment Outcome

2015
[PATHWAY-2 Study: spironolactone vs placebo, bisoprolol and doxazosin to determine optimal treatment of resistant hypertension. Spironolactone high effective in lowering blood pressure in drug resistant hypertension].
    Vnitrni lekarstvi, 2015, Volume: 61, Issue:12

    Topics: Antihypertensive Agents; Bisoprolol; Blood Pressure; Diuretics; Doxazosin; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Spironolactone

2015
PURLs: Resistant hypertension? Time to consider this fourth-line drug.
    The Journal of family practice, 2016, Volume: 65, Issue:4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bisoprolol; Doxazosin; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Spironolactone; Treatment Outcome

2016
Reducing Arterial Stiffness Independently of Blood Pressure: The VaSera Trial.
    Journal of the American College of Cardiology, 2017, 09-26, Volume: 70, Issue:13

    Topics: Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Double-Blind Method; Doxazosin; Humans; Nitrates; Pulse Wave Analysis; Spironolactone; Treatment Outcome; Vascular Stiffness

2017
    Journal of patient-reported outcomes, 2018, Volume: 2

    Topics: Adult; Aged; Animals; Astrocytes; Bariatric Surgery; Beta vulgaris; Bioreactors; Biotechnology; Blood Pressure; Body Mass Index; Cat Diseases; Cats; CD36 Antigens; Cell Cycle; Cell Line; Chitinases; Cohort Studies; Comorbidity; Cytokines; Diabetes Mellitus, Type 2; Double-Blind Method; Doxazosin; Echocardiography; Encephalomyelitis, Autoimmune, Experimental; Endothelial Cells; Fasting; Female; Fruit and Vegetable Juices; Gastric Bypass; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Heart; Heart Failure; Homeostasis; Humans; Hypertension; Hypothyroidism; Inflammation; Interleukin-17; Laparoscopy; Length of Stay; Male; Methanol; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiota; MicroRNAs; Middle Aged; Molecular Imaging; Nitrates; Nutrients; Obesity, Morbid; Pancreatic Neoplasms; Physical Conditioning, Animal; Physical Endurance; Pichia; Placebos; Postoperative Complications; Postoperative Period; Prospective Studies; Pulse Wave Analysis; Radionuclide Imaging; Reoperation; Retrospective Studies; RNA, Messenger; Sequence Analysis, RNA; Signal Transduction; Spectrum Analysis, Raman; Spironolactone; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Thyroid Gland; Thyrotropin; Thyroxine; Treatment Outcome; Ultrasonography; Vascular Stiffness; Weight Loss

2018

Other Studies

16 other study(ies) available for spironolactone and doxazosin

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Spironolactone and doxazosin treatment in patients with resistant hypertension.
    Revista espanola de cardiologia, 2009, Volume: 62, Issue:2

    Topics: Aged; Antihypertensive Agents; Blood Pressure; Diuretics; Doxazosin; Drug Resistance; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Retrospective Studies; Spironolactone; Treatment Outcome

2009
Resistant hypertension. What is the best approach?
    Revista espanola de cardiologia, 2009, Volume: 62, Issue:6

    Topics: Antihypertensive Agents; Doxazosin; Drug Resistance; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Randomized Controlled Trials as Topic; Spironolactone; Vasodilator Agents

2009
Spironolactone for resistant hypertension--hard to resist?
    Lancet (London, England), 2015, Nov-21, Volume: 386, Issue:10008

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-1 Receptor Antagonists; Bisoprolol; Doxazosin; Female; Humans; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Spironolactone

2015
Hypertension: PATHWAY to improving the treatment of drug-resistant hypertension.
    Nature reviews. Nephrology, 2015, Volume: 11, Issue:11

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-1 Receptor Antagonists; Bisoprolol; Doxazosin; Female; Humans; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Spironolactone

2015
ACP Journal Club. In resistant hypertension, add-on spironolactone reduced SBP more than placebo, doxazosin, or bisoprolol over 12 wk.
    Annals of internal medicine, 2016, Feb-16, Volume: 164, Issue:4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-1 Receptor Antagonists; Bisoprolol; Doxazosin; Female; Humans; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Spironolactone

2016
[Spironolactone versus placebo, bisoprolol and doxazosin to determine the optimal treatment for drug-resistant hypertension].
    Semergen, 2016, Volume: 42, Issue:7

    Topics: Antihypertensive Agents; Bisoprolol; Doxazosin; Drug Therapy, Combination; Humans; Hypertension; Spironolactone

2016
PATHWAY-2: spironolactone for resistant hypertension.
    Lancet (London, England), 2016, Apr-02, Volume: 387, Issue:10026

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-1 Receptor Antagonists; Bisoprolol; Doxazosin; Female; Humans; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Spironolactone

2016
PATHWAY-2: spironolactone for resistant hypertension.
    Lancet (London, England), 2016, Apr-02, Volume: 387, Issue:10026

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-1 Receptor Antagonists; Bisoprolol; Doxazosin; Female; Humans; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Spironolactone

2016
PATHWAY-2: spironolactone for resistant hypertension.
    Lancet (London, England), 2016, Apr-02, Volume: 387, Issue:10026

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-1 Receptor Antagonists; Bisoprolol; Doxazosin; Female; Humans; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Spironolactone

2016
PATHWAY-2: spironolactone for resistant hypertension - Authors' reply.
    Lancet (London, England), 2016, Apr-02, Volume: 387, Issue:10026

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-1 Receptor Antagonists; Bisoprolol; Doxazosin; Female; Humans; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Spironolactone

2016
Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.
    The lancet. Diabetes & endocrinology, 2018, Volume: 6, Issue:6

    Topics: Aldosterone; Amiloride; Antihypertensive Agents; Bisoprolol; Blood Pressure; Doxazosin; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Randomized Controlled Trials as Topic; Spironolactone

2018