spironolactone has been researched along with dihydrotestosterone in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (53.66) | 18.7374 |
| 1990's | 4 (9.76) | 18.2507 |
| 2000's | 10 (24.39) | 29.6817 |
| 2010's | 3 (7.32) | 24.3611 |
| 2020's | 2 (4.88) | 2.80 |
| Authors | Studies |
|---|---|
| Haga, N; Kamata, S; Kawabata, T; Kondo, E; Mitsugi, T; Miyata, K; Nagata, W; Nakamura, M; Odaguchi, K; Shimizu, T | 1 |
| Haga, N; Ishibashi, M; Itoh, T; Kamata, S; Matsui, T; Nakamura, M; Odaguchi, K; Shimizu, T; Suzuki, T; Yamada, F | 1 |
| Ernst, B; Lill, MA; Vedani, A; Winiger, F | 1 |
| Bydal, P; Labrie, F; Luu-The, V; Poirier, D | 1 |
| Bellavance, E; Luu-The, V; Poirier, D | 1 |
| Arias, DA; Barbieri, LR; Berrodin, TJ; Bigelis, R; Chang, LP; Luckman, SW; McDonald, LA; Roll, DM; Singh, MP; Yudt, MR | 1 |
| Chai, X; Chen, C; Cui, S; Hou, T; Hu, X; Li, D; Lou, S | 1 |
| Corvol, P; Freifeld, M; Mahoudeau, J; Menard, J; Michaud, A | 1 |
| Lippman, ME; Loriaux, DL; Pita, JC; Thompson, EB | 1 |
| Bricaire, H; Corvol, P; Mahoudeau, JA; Ménard, J; Valcke, JC | 1 |
| Cutler, GB; Loriaux, DL; Menard, RH; Pita, JC; Rifka, SM; Sauer, MA | 1 |
| Claire, M; Corvol, P; Michaud, A; Rafestin-Oblin, ME; Roth-Meyer, C | 1 |
| Frenkl, R; Szeberényi, S | 1 |
| Gangnerau, MN; Picon, R; Rouiller, V | 1 |
| Carmina, E; Lobo, RA | 1 |
| Cusan, L; Labrie, C; Labrie, F; Lapointe, S; Plante, M | 1 |
| Begin, DJ; Labrie, F; Luthy, IA | 1 |
| Bernier, M; Darbeida, H; Durand, P; Penhoat, A; Saez, JM | 1 |
| Gibson, M; Krusinski, PA; Kvedar, JC | 1 |
| Homeida, AM | 1 |
| Bonne, C; Raynaud, JP | 1 |
| Biffignandi, P; Massucchetti, C; Molinatti, GM | 1 |
| Baranowska, B; Szymanowski, J; Zgliczynski, S | 1 |
| Costa, C; De Pedrini, P; Suraci, C | 1 |
| Lobo, RA; Shoupe, D | 1 |
| Claire, M; Lombes, M; Michaud, A; Michiel, JB; Rafestin-Oblin, ME | 1 |
| Creange, JE; Harding, HR; Potts, GO; Schane, HP | 1 |
| Gooren, LJ; Harmsen-Louman, W; van der Veen, EA; van Kessel, H; Wiegel, AR | 1 |
| Adam, WR; Funder, JW; Marver, D; Mercer, JE; Ulick, S | 1 |
| Akamatsu, H; Orfanos, CE; Stephanek, K; Zouboulis, CC | 1 |
| Akamatsu, H; Orfanos, CE; Zouboulis, CC | 1 |
| Bydal, P; Luu-The, V; Poirier, D; Sam, KM; Tremblay, MR | 1 |
| Holst, M; Ritzén, EM; Svechnikov, K | 1 |
| Füessl, HS | 1 |
| Bergfeld, WF; Hordinsky, MK; Messenger, AG; Olsen, EA; Roberts, JL; Shapiro, J; Stough, D; Washenik, K; Whiting, DA | 1 |
| Milan, A; Mulatero, P; Veglio, F; Verhovez, A; Williams, TA | 1 |
| Ito, S; Satoh, F | 1 |
| Funder, JW | 1 |
| Bell, RR; John-Baptiste, A; Levin, S; McMahon, E | 1 |
| Check, JH; Cohen, R | 1 |
| Ganesh, SK; Hunker, KL; Kanthi, Y; Knight, JS; Kumar, N; Obi, AT; Yalavarthi, S; Zuo, Y | 1 |
4 review(s) available for spironolactone and dihydrotestosterone
| Article | Year |
|---|---|
Hirsutism: evaluation and treatment.
Topics: Contraceptives, Oral; Dehydroepiandrosterone; Dexamethasone; Dihydrotestosterone; Female; Hair Removal; Hirsutism; Humans; Neoplasms; Physical Examination; Sex Hormone-Binding Globulin; Spironolactone; Testosterone | 1985 |
Female hirsutism: pathophysiological considerations and therapeutic implications.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adrenal Glands; Adrenocorticotropic Hormone; Androgen Antagonists; Androgens; Androstenedione; Biological Transport, Active; Blood Proteins; Cyproterone; Cyproterone Acetate; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethasone; Dihydrotestosterone; Female; Hirsutism; Humans; Kinetics; Ovary; Sex Hormone-Binding Globulin; Skin; Spironolactone | 1984 |
[Adrenocortical adenoma].
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Aldosterone; Androgens; Biomarkers; Calcium Channel Blockers; Diagnostic Imaging; Dihydrotestosterone; Enzyme Inhibitors; Humans; Hydrocortisone; Metyrapone; Spironolactone | 2006 |
Aldosterone, hypertension and heart failure: insights from clinical trials.
Topics: Aldosterone; Animals; Anticholesteremic Agents; Atorvastatin; Clinical Trials as Topic; Dihydrotestosterone; Drug Therapy, Combination; Enzyme Inhibitors; Female; Heart Failure; Heptanoic Acids; Humans; Hydrocortisone; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Mice; Mineralocorticoid Receptor Antagonists; Ouabain; Pyrroles; Quinolines; Rats; Spironolactone | 2010 |
37 other study(ies) available for spironolactone and dihydrotestosterone
| Article | Year |
|---|---|
Aldosterone antagonists. 1. Synthesis and biological activities of 11 beta,18-epoxypregnane derivatives.
Topics: Animals; Dose-Response Relationship, Drug; Epoxy Compounds; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Pregnanes; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid | 1985 |
Aldosterone antagonists. 2. Synthesis and biological activities of 11,12-dehydropregnane derivatives.
Topics: Adrenalectomy; Animals; Kidney; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Receptors, Androgen; Receptors, Mineralocorticoid; Receptors, Progesterone; Receptors, Steroid; Structure-Activity Relationship | 1987 |
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
Topics: Benzhydryl Compounds; Binding Sites; Diethylstilbestrol; Endocrine System; Hydrocarbons, Chlorinated; Ligands; Models, Molecular; Molecular Conformation; Phenols; Phytoestrogens; Quantitative Structure-Activity Relationship; Receptors, Androgen; Testosterone; Thermodynamics; Xenobiotics | 2005 |
Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities.
Topics: 17-Hydroxysteroid Dehydrogenases; Cell Line; Cell Proliferation; Enzyme Inhibitors; Humans; Lactones; Male; Prostatic Diseases; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone; Steroids; Structure-Activity Relationship | 2009 |
Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
Topics: 17-Hydroxysteroid Dehydrogenases; Androstane-3,17-diol; Androstanes; Biocatalysis; Cell Line; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrone; Humans; Inhibitory Concentration 50; Oxidation-Reduction; Substrate Specificity | 2009 |
The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.
Topics: Animals; Chlorocebus aethiops; Female; Humans; Hypocreales; Indoles; Luciferases; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Progestins; Receptors, Progesterone; Sesquiterpenes | 2009 |
Discovery of 2-(1-(3-Chloro-4-cyanophenyl)-1
Topics: Acetamides; Androgen Antagonists; Androgen Receptor Antagonists; Cell Line, Tumor; Cell Proliferation; Humans; Ligands; Male; Prostatic Neoplasms; Pyrazoles; Receptors, Androgen | 2022 |
Antiandrogenic effect of spirolactones: mechanism of action.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Binding, Competitive; Canrenoic Acid; Cell Nucleus; Cyproterone; Cytosol; Dihydrotestosterone; Hyperaldosteronism; Hypertension; Male; Prostate; Rats; Receptors, Cell Surface; Spironolactone; Tritium | 1975 |
Interaction of spironolactone and digitalis with the 5 alpha-dihydrotestosterone (DHT) receptor of rat ventral prostate.
Topics: Animals; Binding Sites; Cytosol; Digitalis Glycosides; Digitoxin; Digoxin; Dihydrotestosterone; Male; Prostate; Rats; Receptors, Cell Surface; Spironolactone | 1975 |
[Sexual side-effects of spironolactones. Possible mechanisms of their anti-androgen action].
Topics: Adult; Animals; Canrenoic Acid; Cytosol; Depression, Chemical; Dihydrotestosterone; Follicle Stimulating Hormone; Gynecomastia; Humans; Hydroxysteroid Dehydrogenases; Luteinizing Hormone; Male; Pregnadienes; Prostate; Rats; Receptors, Cell Surface; Spironolactone; Testosterone; Tritium | 1976 |
SC 25152: A potent mineralocorticoid antagonist with reduced affinity for the 5 alpha-dihydrotestosterone receptor of human and rat prostate.
Topics: Aldosterone; Animals; Dihydrotestosterone; Humans; Kinetics; Male; Mineralocorticoid Receptor Antagonists; Prostate; Rats; Receptors, Androgen; Receptors, Steroid; Species Specificity; Spironolactone | 1978 |
Mechanism of action of a new antialdosterone compound, prorenone.
Topics: Aldosterone; Animals; Binding, Competitive; Cell Nucleus; Dexamethasone; Dihydrotestosterone; Kidney; Kinetics; Male; Mineralocorticoid Receptor Antagonists; Prostate; Rats; Receptors, Androgen; Receptors, Glucocorticoid; Spironolactone | 1979 |
Enzyme inducing effect of muscular exertion in the rat.
Topics: Animals; Canrenone; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Induction; Hexobarbital; Male; Metabolic Clearance Rate; Muscle Contraction; Physical Exertion; Rats; Sleep; Spironolactone; Swimming | 1976 |
Effects of 17 beta-N,N-diethylcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one on steroidogenesis in gonads of rat fetuses.
Topics: Androgen Antagonists; Animals; Azasteroids; Cholestenone 5 alpha-Reductase; Cyclic AMP; Dihydrotestosterone; Female; Fetus; Gonads; Male; Ovary; Oxidoreductases; Progesterone; Rats; Rats, Wistar; Spironolactone; Testis; Testosterone | 1992 |
Peripheral androgen blockade versus glandular androgen suppression in the treatment of hirsutism.
Topics: Adolescent; Adult; Androgen Antagonists; Androgens; Androstane-3,17-diol; Androstenedione; Androsterone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethasone; Dihydrotestosterone; Drug Combinations; Female; Hirsutism; Humans; Spironolactone; Testosterone | 1991 |
Analysis of the androgenic activity of synthetic "progestins" currently used for the treatment of prostate cancer.
Topics: Adrenal Glands; Animals; Chlormadinone Acetate; Cyproterone; Cyproterone Acetate; Dihydrotestosterone; Flutamide; Male; Medroxyprogesterone; Medroxyprogesterone Acetate; Megestrol; Megestrol Acetate; Organ Size; Ornithine Decarboxylase; Progesterone Congeners; Prostate; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Spironolactone | 1987 |
Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture.
Topics: Androgens; Animals; Cell Division; Chlormadinone Acetate; Dihydrotestosterone; Flutamide; Male; Mammary Neoplasms, Experimental; Medroxyprogesterone; Medroxyprogesterone Acetate; Megestrol; Mice; Progestins; Spironolactone; Tumor Cells, Cultured | 1988 |
Inhibition of hormonal-induced cAMP and steroid production by inhibitors of pregnenolone metabolism in adrenal and Leydig cells.
Topics: Adrenal Glands; Animals; Carrier Proteins; Cattle; Cells, Cultured; Cholesterol; Colforsin; Cyclic AMP; Dihydrotestosterone; Endoribonucleases; Intracellular Signaling Peptides and Proteins; Leydig Cells; Male; Phosphoprotein Phosphatases; Pregnenolone; Proteins; RNA-Binding Proteins; Sheep; Spironolactone; Steroids; Swine; Tetrahydronaphthalenes | 1988 |
Use of spironolactone to investigate the role of testosterone secretion during luteolysis in the goat.
Topics: Animals; Corpus Luteum; Dihydrotestosterone; Female; Goats; Luteolysis; Ovary; Progesterone; Spironolactone; Testosterone | 1986 |
Mode of spironolactone anti-androgenic action: inhibition of androstanolone binding to rat prostate androgen receptor.
Topics: Androgen Antagonists; Animals; Cell Nucleus; Cyproterone; Cytosol; Dihydrotestosterone; Estrenes; Hydroxysteroids; In Vitro Techniques; Ketosteroids; Male; Prostate; Rats; Receptors, Cell Surface; Spironolactone; Testosterone | 1974 |
[The influence of spironolactone on the concentration of gonadotrophins and gonadal hormones in prostatic hypertrophy (author's transl)].
Topics: Aged; Dihydrotestosterone; Estradiol; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Luteinizing Hormone; Male; Middle Aged; Progesterone; Prostatic Hyperplasia; Spironolactone; Testosterone | 1981 |
[Cyproterone acetate and spironolactone compared in the therapy of female hirsutism].
Topics: Adolescent; Adult; Androgen Antagonists; Cyproterone; Cyproterone Acetate; Dihydrotestosterone; Drug Evaluation; Female; Follicle Stimulating Hormone; Hirsutism; Humans; Luteinizing Hormone; Spironolactone; Testosterone; Time Factors | 1983 |
The influence of androgens on insulin resistance.
Topics: Adult; Androgens; Androstane-3,17-diol; Dehydroepiandrosterone; Dihydrotestosterone; Female; Hirsutism; Humans; Insulin; Insulin Resistance; Luteinizing Hormone; Pituitary Hormone-Releasing Hormones; Polycystic Ovary Syndrome; Spironolactone; Testosterone | 1984 |
Mineralocorticoid receptors in the epithelial cells of human colon and ileum.
Topics: Aldosterone; Binding, Competitive; Cold Temperature; Colon; Dexamethasone; Dihydrotestosterone; Epithelium; Estradiol; Female; Humans; Ileum; Kinetics; Male; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone | 1984 |
Inhibition of furosemide-induced kaliuresis in the rat by trilostane, an inhibitor of adrenal steroidogenesis.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenalectomy; Aldosterone; Animals; Dihydrotestosterone; Diuresis; Furosemide; Male; Natriuresis; Potassium; Rats; Rats, Inbred Strains; Spironolactone | 1984 |
Prolactin secretion in the human male is increased by endogenous oestrogens and decreased by exogenous/endogenous androgens.
Topics: Adult; Castration; Dihydrotestosterone; Estradiol; Humans; Male; Middle Aged; Prolactin; Spironolactone; Testolactone; Testosterone | 1984 |
Toward more specific aldosterone antagonists. A radioreceptor assay approach.
Topics: Aldosterone; Animals; Dexamethasone; Dihydrotestosterone; Estradiol; Progesterone; Rats; Receptors, Androgen; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid; Spironolactone | 1980 |
Androgens affect the activity of human sebocytes in culture in a manner dependent on the localization of the sebaceous glands and their effect is antagonized by spironolactone.
Topics: Adult; Androgen Antagonists; Androgens; Cell Division; Cells, Cultured; Dihydrotestosterone; Face; Female; Humans; Leg; Male; Sebaceous Glands; Spironolactone; Testosterone | 1994 |
Spironolactone directly inhibits proliferation of cultured human facial sebocytes and acts antagonistically to testosterone and 5 alpha-dihydrotestosterone in vitro.
Topics: Cell Division; Cells, Cultured; Dihydrotestosterone; Dose-Response Relationship, Drug; Face; Humans; Sebaceous Glands; Spironolactone; Testosterone | 1993 |
Inhibitors of type II 17beta-hydroxysteroid dehydrogenase.
Topics: 17-Hydroxysteroid Dehydrogenases; Cell Line; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Female; Humans; Isoenzymes; Kidney; NADP; Placenta; Recombinant Proteins; Spironolactone; Steroids; Structure-Activity Relationship; Testosterone; Transfection | 2001 |
Androgen and estrogen stimulation of ornithine decarboxylase activity in mouse kidney.
Topics: Androgen Antagonists; Animals; Cyproterone Acetate; Dichlorodiphenyl Dichloroethylene; Dihydrotestosterone; Estradiol; Female; Flutamide; Kidney; Mice; Mice, Inbred CBA; Ornithine Decarboxylase; Oxazoles; Spironolactone; Testosterone | 2000 |
[Secondary forms of hypertension. 5. Hypertension caused by Cushing syndrome and Conn's disease].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Algorithms; Cushing Syndrome; Diagnosis, Differential; Dihydrotestosterone; Diuretics; Enzyme Inhibitors; Humans; Hyperaldosteronism; Hypertension; Magnetic Resonance Angiography; Mineralocorticoid Receptor Antagonists; Pituitary Neoplasms; Spironolactone; Tomography, X-Ray Computed | 2002 |
Evaluation and treatment of male and female pattern hair loss.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Administration, Topical; Adolescent; Adult; Alopecia; Androgen Antagonists; Contraindications; Cosmetic Techniques; Cyproterone Acetate; Diagnosis, Differential; Dihydrotestosterone; Female; Finasteride; Gonadal Steroid Hormones; Hair; Hair Follicle; Humans; Hypothyroidism; Iron Deficiencies; Isoenzymes; Male; Middle Aged; Minoxidil; Receptors, Androgen; Sex Characteristics; Spironolactone | 2005 |
Protective effect of spironolactone on endothelial cell apoptosis.
Topics: Aldosterone; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Nucleus; Cell Survival; Cells, Cultured; Cytochromes c; Cytosol; Dexamethasone; Dihydrotestosterone; Endothelial Cells; Enzyme Activation; Eplerenone; Humans; Hydrocortisone; Mineralocorticoid Receptor Antagonists; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Poly(ADP-ribose) Polymerases; Receptors, Progesterone; Spironolactone; Time Factors; Umbilical Veins | 2006 |
Prostate effect in dogs with the aldosterone receptor blocker eplerenone.
Topics: Animals; Atrophy; Dihydrotestosterone; Dogs; Eplerenone; Finasteride; Histocytochemistry; Male; Mineralocorticoid Receptor Antagonists; Organ Size; Prostate; Protein Binding; Receptors, Androgen; Spironolactone | 2013 |
Dihydrotestosterone may contribute to the development of migraine headaches.
Topics: 5-alpha Reductase Inhibitors; Contraceptives, Oral; Dextroamphetamine; Dihydrotestosterone; Female; Finasteride; Humans; Migraine Disorders; Polycystic Ovary Syndrome; Spironolactone; Young Adult | 2013 |
SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism.
Topics: Angiotensin Receptor Antagonists; Cell Adhesion Molecules; Cells, Cultured; COVID-19; Dihydrotestosterone; Endothelium, Vascular; Female; Humans; Inflammation; Male; SARS-CoV-2; Sex Characteristics; Spike Glycoprotein, Coronavirus; Spironolactone; Tumor Necrosis Factor-alpha; Valsartan | 2021 |