Page last updated: 2024-08-17

spironolactone and digoxin

spironolactone has been researched along with digoxin in 166 studies

Research

Studies (166)

Timeframe	Studies, this research(%)	All Research%
pre-1990	81 (48.80)	18.7374
1990's	15 (9.04)	18.2507
2000's	44 (26.51)	29.6817
2010's	22 (13.25)	24.3611
2020's	4 (2.41)	2.80

Authors

Authors	Studies
Hashimoto, Y; Ibaramoto, K; Inui, KI; Masuda, S; Saito, H; Takeuchi, A	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Florence, AT; Salole, EG	1
Born, CK; Davidson, CP; Hamrick, ME; Musgrave, GE	1
Lippman, ME; Loriaux, DL; Pita, JC; Thompson, EB	1
Wachter, C; Wood, WG	1
Heinz, N; Rietbrock, N	1
Jefferys, DB	1
Hutcheon, AW; Jick, H; Lawson, DH	1
Lichey, J; Rietbrock, N; Schröder, R	2
Bräuer, H; Müller, H; Resch, B	1
Andersen, JD; Heebøll-Nielsen, N; Moltke, E; Nielsen, OG; Steiness, E; Sørensen, U; Waldorff, S	1
Bass, O; Baur, HR; Masson, JP; Ohnhaus, EE	1
Berger, E; Cristodorescu, R; Deutsch, G; Gavrilescu, S	1
Powers, JL; Sadée, W; Sheiner, LB; Silber, B; Winter, ME	1
Kistner, M; Reisert, VP	1
Boink, AB; Kruyswijk, HH; Maas, AH; Willebrands, AF	1
Masson, JP; Ohnhaus, EE	1
Follath, F; Fridrich, R; Peyer, H; Roth, M; Wenk, M	1
Abshagen, U; Kuhlmann, J; Rennekamp, H	1
Espiner, EA; Hughes, H; Nicholls, MG; Rogers, T	1
Alakare, B; Kärki, NT; Nevasaari, K	1
Olesen, KH; Sigurd, B; Wennevold, A	1
Rietbrock, N; VOHRINGER, HF; Weller, L	1
Köthe, E; Kramer, P; Saul, J; Scheler, F	1
Ravel, R	1
Krusteva, E	1
Hedman, A	1
Angelin, B; Arvidsson, A; Dahlqvist, R; Hedman, A	1
Foukaridis, GN	1
Cacini, W; Wernke, MJ	1
Hicks, JM; Iosefsohn, M; Soldin, SJ	1
Gadsden, RH; Pleasants, RA; Porter, RS; Williams, DM	1
Crothers, DC	1
Frewin, DB; Glistak, ML; Lehmann, DR; Morris, RG; Taylor, WB	1
Burnet, RB; Frewin, DB; Glistak, ML; Lagnado, PY; Lehmann, DR; Morris, RG	1
Koren, G	1
Gibson, TP; O'Brien, MS; Salamone, LF	1
Abshagen, U	1
Koch, K; Mattern, HR; Schaumann, W	1
Frölich, JC; Wirth, KE	2
Klaassen, CD	1
Arbeiter, G; Cordes, R; Kötter, V; Kuhlmann, J; Schröder, R; von Leitner, E	1
Cohn, JN; Franciosa, JA; Mathew, KJ; Snow, JA	1
Fleming, JS	1
Huffman, DH	1
Rawlins, MD	1
Phillips, AP	1
Shah, S	1
Ghabussi, P; Hochrein, H; Krämer, KD	1
Castle, MC; Lage, GL	1
Olesen, KH; Valentin, N	1
Bolte, HD; Buckesfeld, RP; Lankisch, PG; Larbig, D; von Lilienfeld-Toal, H	1
Boink, AB; Jambroes, G; Kruyswijk, HH; Maas, AH; Willebrands, AF	1
Steiness, E	1
Hüsten, J; Ruiz-Torres, A	1
Biamino, G; Dennert, J; Meyer, V; Sadée, W; Schröder, R; Schüren, KP	1
Mécs, I; Selye, H; Tamura, T	1
Betzien, G; Krecke, HJ; Timmler, R	1
Bacciarelli, C	1
Klaassen, CD; Siegers, CP	1
Cape, RD; Finnegan, TP; Spence, JD	1
Jahodová, J; Kölbel, F; Kubová, V; Pribyl, T; Schreiber, V; Stĕpan, J	1
Gumbiner, CH; Howell, DM; Martin, GE	1
Daum, S; Goerg, R; Mack, D; Wang, D	1
Chen, JH; Chen, JS; Hsieh, YY; Hsu, JC; Hsu, KL; Hsu, WS; Lin, MS; Shu, MY; Su, CT; Wu, TL	1
Davidson, KH; McCall, BB; Paladino, JA	1
Fenster, PE; Goodman, MM; Hager, WD	1
Sato, T	1
Berning, J; Buch, J; Egeblad, H; Hansen, PB; Kjaergård, H; Steiness, E; Waldorff, S	1
Scott, B	1
Hjalmarson, A; Swedeberg, K; Waagstein, F; Wallentin, I	1
Maddox, RR; Thomas, RW	1
Fowler, RS; Hobbins, SM; Korey, AG; Rowe, RD	1
Berning, J; Buch, J; Steiness, E; Waldorff, S	1
Soyka, LF	1
Bustrack, JA; Cote, JR; DiPiro, CR; DiPiro, JT	1
Hyneck, ML; Johnson, MH	1
Bergdähl, B; Molin, L	1
Armijo, JA; Padrón, FA	1
Castle, MC	1
Ogawa, K; Suzuki, M	1
Anders, JC; Crisona, FJ; Hamrick, ME	1
Lloveres, J; Pérez Fontán, J; Tato, F	1
Bharani, A; Bhargava, KD; Ganguly, A	1
Calderón, RB; de Macedo, IL	1
Barrera Ruiz, ML; Castillo Camacho, JA; Descalzo Señorans, A; González Barrero, A; Sáez Ariza, C; Santos de Soto, J	1
Ghali, JK; Graves, SW; Liendo, C	1
Ohta, H	1
Higuchi, S; Minemoto, M; Suematsu, F; Yukawa, E	1
Eber, B; Emmanuilidis, K; Müller, C; Steimer, W	1
Fernandez, HM; Leipzig, RM	1
Young, J	1
Moore, CK	1
Barbour, MM; Zuwallack, A	1
Parmley, WW	1
Goto, Y; Higuchi, S; Minemoto, M; Ohdo, S; Suematsu, F; Yukawa, E; Yukawa, M	2
Agustí Escasany, A; Arnau De Bolós, JM; Casas Rodríguez, J; Diogène Fadini, E; Durán Dalmau, M; Galve Basilio, E; Manito Lorite, N; Rodríguez Cumplido, D	1
Clark, A; Cleland, JG; Dhawan, J; John, J	1
Eber, B; Müller, C; Steimer, W	1
Dasgupta, A	1
Dasgupta, A; Datta, P; Saffer, H; Wells, A	1
McKelvie, R	4
Ichikawa, S; Kasama, S; Kumakura, H; Kurabayashi, M; Suzuki, T; Takayama, Y; Toyama, T	1
Gould, PA; Kaye, DM	1
Barclay, M; Florkowski, C; Howard, G; Moore, G; Roche, A	1
Amasaki, H; Hirose, H; Machida, N; Nakagawa, K; Takemura, N; Washizu, M	1
Dasgupta, A; Datta, P	1
Steimer, W	1
Denvir, MA; LeMaitre, JP; Leslie, SJ; McKee, SP; Webb, DJ	1
DE GRAEFF, J; LAMEIJER, LD	1
Taylor, AL	1
Gaulden, L	1
Cowley, AJ; McKenzie, DB	1
Klues, HG; Martin, N; Ott, R	1
Pitt, B	1
Conthe, P; Forteza-Rey, J; García-Alegría, J; Montero, M; Montoto, C; Román-Sánchez, P	1
Haaijer-Ruskamp, FM; Jaarsma, T; Sturm, H; Van Veldhuisen, DJ	1
Cox, JL; Humphries, K; Lee, DS; Pilote, L; Ramer, SA; Svenson, L; Tu, JV	1
Hervas-Malo, M; Jacobs, P; Nilsson, C; Shibata, MC; Tsuyuki, RT	1
Arana, MC; Bengochea, LA; Catania, VA; Delli Carpini, G; Ghanem, CI; Gómez, PC; Luquita, MG; Mottino, AD; Perassolo, M; Veggi, LM	1
Bolling, SF; Geltz, A; Spoor, MT	1
Dasgupta, A; Datta, P; Kang, E	1
Ezekowitz, JA; Lee, DS; McAlister, FA; Newman, AM; Tu, JV	1
Cordina, J; Norris, CA; Ogundipe, OA	1
Dasgupta, A; Tso, G; Wells, A	1
Altenberger, H; Finsterer, J; Stöllberger, C	1
Ceri, O; Koçak, OM; Soykan, A; Tatlidil, E; Yilmaz, A	1
Mehta, S; Vijayakumar, M	1
Hayashi, T; Iguchi, K; Ijiri, Y; Kanada, Y; Kato, R; Murakami, S; Nishihara, M; Suzuki, K; Tamai, H; Tanaka, K; Yamada, T	1
Akchurin, RS; Chernova, NA; Erastova, NV; Grishin, IR; Karpov, IuA; Latypov, RS; Lopukhova, VV; Mareev, IuV; Saidova, MA; Sapel'nikov, OV	1
Armbruster, D; Cooper, KC; Dasgupta, A; DeFrance, A; Petty, D	1
Dasgupta, A; Johnson, MJ	1
Büller, HR; de Boer, A; de Peuter, OR; Kamphuisen, PW; Klungel, OH; Lip, GY; Souverein, PC	1
Alabd, A; Gamal, A; Rayan, M; Tawfik, M	1
Biggar, RJ	1
Dasgupta, A; Johnson, MJ; Sengupta, TK	1
Hamed, SS; Volpe, DA; Zhang, LK	1
Haythe, J; Lewey, J	1
Agra, Y; Moreno-Gómez, AM; Otero, MJ; Santos-Ramos, B	1
Eurich, DT; McAlister, FA; Murphy, GK	1
Getachew, H; Shibeshi, W; Tadesse, Y	1
Malebranche, R; Morisset, PH; Raphael, NA; Tabou Moyo, C; Wilentz, JR	1
Baez, A; Bazán, C; Camino Willhuber, GO; Fretes, R; Guzman Mentesana, G; Lo Presti, S; Paglini-Oliva, PA; Rivarola, HW; Strauss, M	1
Franken, PR; Woltersdorf, R	1
Abdel Jalil, MH; Abdullah, N; Abu-Hammour, K; Alsous, MM; Saleh, M	1
Du, P; Jia, A; Li, X; Li, Y; Ma, Y; Wang, A	2
Dizaye, KF; Z Rashid, B	1

Reviews

21 review(s) available for spironolactone and digoxin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Variability in response to drugs. British medical journal, 1974, Oct-12, Volume: 4, Issue:5936 Topics: Acute Disease; Acylation; Chlorthalidone; Chronic Disease; Depression; Diazoxide; Digoxin; Dose-Response Relationship, Drug; Glomerulonephritis; Humans; Hypertension; Nephrotic Syndrome; Norepinephrine; Nortriptyline; Oxidation-Reduction; Phenylthiourea; Serotonin; Spironolactone; Steroids	1974
[The importance of the biliary excretion of drugs in the human]. Deutsche medizinische Wochenschrift (1946), 1983, Oct-14, Volume: 108, Issue:41 Topics: Anti-Bacterial Agents; Antineoplastic Agents; Bile; Biological Transport; Cardiac Glycosides; Contraceptives, Oral, Hormonal; Diazepam; Digoxin; Enterohepatic Circulation; Fluorenes; Half-Life; Hexamethonium Compounds; Humans; Imipramine; Indocyanine Green; Kidney Diseases; Liver Diseases; Molecular Weight; Pharmaceutical Preparations; Spironolactone	1983
[Clinical pharmacology of digitalis glycosides]. Nihon rinsho. Japanese journal of clinical medicine, 1982, Volume: 40, Issue:11 Topics: Digitalis Glycosides; Digitoxin; Digoxin; Drug Interactions; Furosemide; Humans; Kinetics; Quinidine; Spironolactone; Vasodilator Agents	1982
The interaction of spironolactone and digoxin: a review and evaluation. Therapeutic drug monitoring, 1981, Volume: 3, Issue:2 Topics: Digoxin; Drug Interactions; Humans; Kinetics; Radioimmunoassay; Spironolactone	1981
Pharmacotherapy of systolic heart failure: emphasis on mortality outcomes. Medicine and health, Rhode Island, 2001, Volume: 84, Issue:2 Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Digoxin; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone; Survival Analysis	2001
[Evidence based medical treatment of heart failure]. Revista espanola de cardiologia, 2001, Volume: 54, Issue:6 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Anticoagulants; Calcium Channel Blockers; Cardiotonic Agents; Cost-Benefit Analysis; Digoxin; Diuretics; Evidence-Based Medicine; Heart Failure; Humans; Spironolactone; Vasodilator Agents	2001
What is the optimal medical management of ischaemic heart failure? British medical bulletin, 2001, Volume: 59 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Cardiotonic Agents; Digoxin; Diuretics; Heart Failure; Humans; Hypolipidemic Agents; Myocardial Ischemia; Myocardial Revascularization; Nitrates; Patient Selection; Smoking Cessation; Spironolactone; Thrombolytic Therapy	2001
Endogenous and exogenous digoxin-like immunoreactive substances: impact on therapeutic drug monitoring of digoxin. American journal of clinical pathology, 2002, Volume: 118, Issue:1 Topics: Cardenolides; Cross Reactions; Digoxin; Drug Monitoring; Drugs, Chinese Herbal; Humans; Immunoassay; Saponins; Spironolactone	2002
Heart failure. Clinical evidence, 2002, Issue:7 Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiovascular Agents; Combined Modality Therapy; Defibrillators, Implantable; Digoxin; Exercise; Heart Failure; Humans; Patient Care Team; Randomized Controlled Trials as Topic; Spironolactone; Survival Rate; Treatment Outcome	2002
Clinical treatment regimens for chronic heart failure: a review. Expert opinion on pharmacotherapy, 2002, Volume: 3, Issue:11 Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Cardiotonic Agents; Digoxin; Diuretics; Heart Failure; Humans; Hydralazine; Isosorbide Dinitrate; Pacemaker, Artificial; Spironolactone; Vasodilator Agents	2002
Heart failure. Clinical evidence, 2002, Issue:8 Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiovascular Agents; Combined Modality Therapy; Defibrillators, Implantable; Digoxin; Exercise; Heart Failure; Humans; Spironolactone	2002
Diagnosis and management of heart failure in the long-term care setting. Director (Cincinnati, Ohio), 2003,Fall, Volume: 11, Issue:4 Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Cardiovascular Agents; Chronic Disease; Digoxin; Diuretics; Drug Interactions; Echocardiography; Heart Failure; Humans; Long-Term Care; Receptors, Angiotensin; Spironolactone	2003
Drug therapy in chronic heart failure. Postgraduate medical journal, 2003, Volume: 79, Issue:937 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Cardiovascular Agents; Chronic Disease; Digoxin; Diuretics; Female; Heart Failure; Humans; Male; Middle Aged; Spironolactone; Vasodilator Agents	2003
Effect of aldosterone blockade in patients with systolic left ventricular dysfunction: implications of the RALES and EPHESUS studies. Molecular and cellular endocrinology, 2004, Mar-31, Volume: 217, Issue:1-2 Topics: Aldosterone; Angiotensin Receptor Antagonists; Digoxin; Enzyme Inhibitors; Eplerenone; Female; Humans; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Randomized Controlled Trials as Topic; Spironolactone; Systole; Ventricular Dysfunction, Left	2004
Heart failure. Clinical evidence, 2004, Issue:11 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Aspirin; Calcium Channel Blockers; Defibrillators, Implantable; Digoxin; Exercise; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Platelet Aggregation Inhibitors; Spironolactone; Warfarin	2004
Management of heart failure in The Netherlands. European journal of heart failure, 2005, Mar-16, Volume: 7, Issue:3 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiology; Digoxin; Diuretics; Family Practice; Heart Failure; Humans; Incidence; Netherlands; Practice Guidelines as Topic; Prevalence; Spironolactone	2005
Heart failure. Clinical evidence, 2004, Issue:12 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Aspirin; Calcium Channel Blockers; Cardiotonic Agents; Defibrillators, Implantable; Digoxin; Exercise; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Platelet Aggregation Inhibitors; Spironolactone; Warfarin	2004
Molecular pathways: digoxin use and estrogen-sensitive cancers--risks and possible therapeutic implications. Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Apr-15, Volume: 18, Issue:8 Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Digoxin; Estrogens; Female; Humans; Male; Neoplasms, Hormone-Dependent; Phytoestrogens; Receptors, Estrogen; Risk Factors; Selective Estrogen Receptor Modulators; Spironolactone; Tamoxifen; Uterine Neoplasms	2012
Cardiomyopathy in pregnancy. Seminars in perinatology, 2014, Volume: 38, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Anesthesia, Obstetrical; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Cardiomyopathies; Contraindications; Digoxin; Diuretics; Female; Heart Failure; Humans; Incidence; Infant, Newborn; Maternal Age; Maternal Mortality; Postpartum Period; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Pregnancy, High-Risk; Prognosis; Risk Factors; Spironolactone; Treatment Outcome	2014
A systematic review of population pharmacokinetic analyses of digoxin in the paediatric population. British journal of clinical pharmacology, 2020, Volume: 86, Issue:7 Topics: Child; Digoxin; Heart Failure; Humans; Infant; Infant, Newborn; Models, Biological; Nonlinear Dynamics; Pediatrics; Spironolactone	2020

Trials

8 trial(s) available for spironolactone and digoxin

Article	Year
The supra-additive natriuretic effect addition of bendroflumethiazide and bumetanide in congestive heart failure. Permutation trial tests in patients in long-term treatment with bumetanide. American heart journal, 1975, Volume: 89, Issue:2 Topics: Adult; Bendroflumethiazide; Benzoates; Butylamines; Chlorides; Clinical Trials as Topic; Coronary Disease; Creatine; Digoxin; Diuretics; Drug Synergism; Drug Therapy, Combination; Female; Heart Failure; Humans; Male; Natriuresis; Nephrons; Placebos; Potassium; Potassium Chloride; Sodium; Spironolactone; Sulfonamides	1975
Digoxin-interactions in man: spironolactone reduces renal but not biliary digoxin clearance. European journal of clinical pharmacology, 1992, Volume: 42, Issue:5 Topics: Adult; Bile; Digoxin; Drug Interactions; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Spironolactone	1992
Potassium-sparing diuretics: interaction with digoxin in elderly men. Journal of the American Geriatrics Society, 1984, Volume: 32, Issue:2 Topics: Aged; Clinical Trials as Topic; Digoxin; Diuretics; Drug Interactions; Erythrocytes; Female; Furosemide; Humans; Hydrochlorothiazide; Male; Middle Aged; Potassium; Spironolactone; Triamterene	1984
Spironolactone therapy in infants with congestive heart failure secondary to congenital heart disease. Archives of disease in childhood, 1981, Volume: 56, Issue:12 Topics: Chlorothiazide; Clinical Trials as Topic; Digoxin; Drug Therapy, Combination; Female; Heart Defects, Congenital; Heart Failure; Humans; Infant; Male; Potassium; Random Allocation; Spironolactone	1981
Systolic time intervals during spironolactone treatment of digitalized and non-digitalized patients with ischaemic heart disease. European journal of clinical pharmacology, 1982, Volume: 21, Issue:4 Topics: Aged; Blood Pressure; Body Weight; Coronary Disease; Depression, Chemical; Digoxin; Drug Interactions; Humans; Middle Aged; Myocardial Contraction; Potassium; Spironolactone; Systole	1982
Salutary effect of Terminalia Arjuna in patients with severe refractory heart failure. International journal of cardiology, 1995, Volume: 49, Issue:3 Topics: Adult; Aged; Cardiomyopathy, Dilated; Chemotherapy, Adjuvant; Chronic Disease; Coronary Disease; Cross-Over Studies; Digoxin; Double-Blind Method; Female; Furosemide; Heart Failure; Heart Function Tests; Humans; Hypertension; India; Male; Middle Aged; Plants, Medicinal; Quality of Life; Spironolactone; Treatment Outcome; Ventricular Function, Left; Weight Loss	1995
Spironolactone improves cardiac sympathetic nerve activity and symptoms in patients with congestive heart failure. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2002, Volume: 43, Issue:10 Topics: 3-Iodobenzylguanidine; Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Digoxin; Diuretics; Drug Therapy, Combination; Female; Heart; Heart Failure; Humans; Iodine Radioisotopes; Male; Radionuclide Imaging; Radiopharmaceuticals; Spironolactone; Stroke Volume; Sympathetic Nervous System	2002
Ivabradine, a novel heart rate slower: is it a sword of double blades in patients with idiopathic dilated cardiomyopathy? Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2011, Volume: 11, Issue:5 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Benzazepines; Carbazoles; Cardiomyopathy, Dilated; Cardiotonic Agents; Carvedilol; Digoxin; Diuretics; Drug Therapy, Combination; Echocardiography; Electrocardiography; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Ivabradine; Male; Middle Aged; Propanolamines; Prospective Studies; Spironolactone; Vasodilator Agents; Ventricular Premature Complexes	2011

Other Studies

137 other study(ies) available for spironolactone and digoxin

Article	Year
Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney. Molecular pharmacology, 1999, Volume: 55, Issue:4 Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Kidney; Male; Membrane Proteins; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Oocytes; Organic Anion Transporters; Rats; Rats, Wistar; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Tissue Distribution; Transfection; Xenopus laevis	1999
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Changes in crystallinity and solubility on comminution of digoxin and observations on spironolactone and oestradiol. The Journal of pharmacy and pharmacology, 1976, Volume: 28, Issue:8 Topics: Chemistry, Pharmaceutical; Crystallization; Differential Thermal Analysis; Digoxin; Estradiol; Microscopy, Electron, Scanning; Particle Size; Powders; Solubility; Spectrophotometry, Infrared; Spironolactone; X-Ray Diffraction	1976
Interaction of spironolactone and digoxin in dogs. The Journal of pharmacology and experimental therapeutics, 1977, Volume: 202, Issue:3 Topics: Adenosine Triphosphatases; Animals; Arrhythmias, Cardiac; Biological Availability; Blood Pressure; Digoxin; Dogs; Drug Interactions; Female; In Vitro Techniques; Male; Membranes; Myocardial Contraction; Myocardium; Potassium; Sodium; Spironolactone	1977
Interaction of spironolactone and digitalis with the 5 alpha-dihydrotestosterone (DHT) receptor of rat ventral prostate. Endocrinology, 1975, Volume: 97, Issue:6 Topics: Animals; Binding Sites; Cytosol; Digitalis Glycosides; Digitoxin; Digoxin; Dihydrotestosterone; Male; Prostate; Rats; Receptors, Cell Surface; Spironolactone	1975
A critical appraisal of a further three new commercial digoxin radioimmunoassay kits with reference to cross-reacting substances. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1979, Volume: 17, Issue:2 Topics: Blood Proteins; Canrenone; Cross Reactions; Digitoxin; Digoxin; Evaluation Studies as Topic; Furosemide; Humans; Radioimmunoassay; Reagent Kits, Diagnostic; Spironolactone	1979
Relationship between dose and plasma level of digoxin and patient characteristics. European journal of clinical pharmacology, 1979, Mar-26, Volume: 15, Issue:2 Topics: Adult; Aged; Digoxin; Dose-Response Relationship, Drug; Female; Humans; Kidney Function Tests; Male; Middle Aged; Spironolactone	1979
Painful gynaecomastia treated with tamoxifen. British medical journal, 1979, Apr-28, Volume: 1, Issue:6171 Topics: Aged; Bronchial Neoplasms; Digoxin; Gynecomastia; Humans; Male; Middle Aged; Spironolactone; Tamoxifen	1979
Life threatening drug reactions amongst medical in-patients. Scottish medical journal, 1979, Volume: 24, Issue:2 Topics: Aged; Arrhythmias, Cardiac; Bethanidine; Digoxin; Drug-Related Side Effects and Adverse Reactions; Female; Furosemide; Humans; Hyperkalemia; Hypotension, Orthostatic; Male; Middle Aged; Spironolactone; Uremia	1979
The effect of oral spironolactone and intravenous canrenoate-K on the digoxin radioimmunoassay. International journal of clinical pharmacology and biopharmacy, 1977, Volume: 15, Issue:12 Topics: Canrenoic Acid; Digoxin; Drug Interactions; Humans; Pregnadienes; Radioimmunoassay; Spironolactone; Time Factors	1977
Cross reactivity of digitoxin and spironolactone in two radioimmunoassays for serum digoxin. Clinical chemistry, 1978, Volume: 24, Issue:4 Topics: Cross Reactions; Digitalis Glycosides; Digitonin; Digoxin; Evaluation Studies as Topic; Humans; Male; Methods; Radioimmunoassay; Spironolactone	1978
Spironolactone-induced changes in digoxin kinetics. Clinical pharmacology and therapeutics, 1978, Volume: 24, Issue:2 Topics: Adult; Aged; Digoxin; Drug Interactions; Half-Life; Humans; Kinetics; Middle Aged; Models, Biological; Spironolactone; Time Factors	1978
[The pharmacokinetics of digoxin during chronic spironolacton treatment (author's transl)]. Klinische Wochenschrift, 1978, Nov-01, Volume: 56, Issue:21 Topics: Adult; Aged; Antipyrine; Digoxin; Feces; Female; Half-Life; Heart Failure; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Spironolactone	1978
Plasma digoxin radioimmunoassay in patients treated with potassium canrenoate and spironolactone. A comparison of two commerical kits. Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1978, Volume: 19, Issue:6 Topics: Adult; Aged; Canrenoic Acid; Digoxin; Female; Humans; Male; Middle Aged; Pregnadienes; Radioimmunoassay; Reagent Kits, Diagnostic; Spironolactone	1978
Spironolactone-associated digoxin radioimmunoassay interference. Clinical chemistry, 1979, Volume: 25, Issue:1 Topics: Digoxin; Humans; Iodine Radioisotopes; Male; Radioimmunoassay; Spironolactone; Tritium	1979
[Clinically significant cross reactions in radioimmunological determination of digoxin]. Fortschritte der Medizin, 1977, Jan-20, Volume: 95, Issue:3 Topics: Adult; Antigen-Antibody Reactions; Cross Reactions; Digoxin; False Positive Reactions; Female; Humans; Lanatosides; Male; Pregnancy; Radioimmunoassay; Spironolactone; Strophanthins; Triamterene	1977
[Plasma-digoxin concentration in patients at time of hospital admission (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1977, Jul-22, Volume: 102, Issue:29 Topics: Ambulatory Care; Canrenoic Acid; Creatinine; Digitalis Glycosides; Digoxin; Female; Hospitalization; Humans; Male; Radioimmunoassay; Spironolactone	1977
Some factors affecting a commercial kit for radioimmunoassay of digoxin using tritiated digoxin. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1977, Volume: 15, Issue:5 Topics: Amniotic Fluid; Chemical Phenomena; Chemistry; Cross Reactions; Digitoxin; Digoxin; Ethanol; Female; Fetal Blood; Humans; Male; Polygeline; Pregnancy; Radioimmunoassay; Spironolactone	1977
The influence of therapeutic doses of spironolactone on the liver microsomal enzyme system and digoxin elimination in man [proceedings]. British journal of clinical pharmacology, 1977, Volume: 4, Issue:5 Topics: Digoxin; Humans; Microsomes, Liver; Spironolactone	1977
[Determination of serum digoxin: a path to better control of therapy?]. Schweizerische medizinische Wochenschrift, 1977, Nov-05, Volume: 107, Issue:44 Topics: Arrhythmias, Cardiac; Digitalis Glycosides; Digoxin; Drug Interactions; Humans; Spironolactone	1977
Effects of pretreatment with spironolactone of pharmacokinetics of 4'''-methyldigoxin in man. Naunyn-Schmiedeberg's archives of pharmacology, 1976, Volume: 292, Issue:1 Topics: Administration, Oral; Adult; Bile; Canrenoic Acid; Canrenone; Digoxin; Feces; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Spironolactone; Tritium	1976
Effect of potassium-sparing diuretics on the renin-angiotensin-aldosterone system and potassium retention in heart failure. British heart journal, 1976, Volume: 38, Issue:10 Topics: Adult; Aged; Aldosterone; Amiloride; Angiotensin II; Digoxin; Female; Furosemide; Heart Failure; Humans; Male; Middle Aged; Potassium; Renin; Sodium; Spironolactone; Urea	1976
Different effects of microsomal enzyme inducers on the biliary excretion of digoxin. Acta pharmacologica et toxicologica, 1976, Volume: 39, Issue:4 Topics: Animals; Benzopyrenes; Bile; Digoxin; Enzyme Induction; Liver; Male; Microsomes, Liver; Perfusion; Phenobarbital; Rats; Spironolactone	1976
Influence of spironolactone pretreatment on pharmacokinetics and metabolism of digitoxin in rats. Naunyn-Schmiedeberg's archives of pharmacology, 1975, Volume: 287, Issue:2 Topics: Animals; Chloroform; Chromatography, Thin Layer; Digitoxigenin; Digitoxin; Digoxin; Drug Interactions; Female; Glucuronates; Half-Life; Hydroxylation; Kinetics; Liver; Rats; Solubility; Spironolactone; Tritium	1975
[Simplified rapid determination of plasma digoxin. Methods and clinical evaluation]. Klinische Wochenschrift, 1975, Mar-01, Volume: 53, Issue:5 Topics: Anuria; Binding Sites, Antibody; Digoxin; Drug Tolerance; False Positive Reactions; Humans; Iodine Radioisotopes; Potassium; Radioimmunoassay; Renal Dialysis; Spironolactone; Tachycardia; Time Factors; Tritium	1975
Negligible interference by spironolactone and prednisone in digoxin radioimmunoassay. Clinical chemistry, 1975, Volume: 21, Issue:12 Topics: Digoxin; Evaluation Studies as Topic; Humans; Prednisone; Radioimmunoassay; Spironolactone	1975
Changes in the plasma levels and basic pharmacokinetic parameters of digoxin used in combination with gentamicin, amiodarone and spironolactone. Folia medica, 1992, Volume: 34, Issue:2 Topics: Amiodarone; Animals; Digoxin; Drug Interactions; Gentamicins; Half-Life; Male; Rabbits; Spironolactone	1992
Inhibition by basic drugs of digoxin secretion into human bile. European journal of clinical pharmacology, 1992, Volume: 42, Issue:4 Topics: Bile; Chromatography, High Pressure Liquid; Digoxin; Drug Interactions; Humans; Probenecid; Quinidine; Quinine; Radioimmunoassay; Spironolactone; Verapamil	1992
Influence of spironolactone and its metabolite canrenone on serum digoxin assays. Therapeutic drug monitoring, 1990, Volume: 12, Issue:1 Topics: Canrenone; Cross Reactions; Digoxin; Half-Life; Humans; Iodine Radioisotopes; Pregnadienes; Radioimmunoassay; Spironolactone	1990
Concentrative uptake of digoxin by slices of chicken renal cortex. Biochemical pharmacology, 1990, Feb-15, Volume: 39, Issue:4 Topics: Animals; Chickens; Digitoxin; Digoxigenin; Digoxin; Female; Hexoses; Kidney Cortex; Kinetics; Ouabain; Potassium; Probenecid; Quinine; Sodium Cyanide; Spironolactone	1990
A dry-strip immunometric assay for digoxin on the Ames Seralyzer. Therapeutic drug monitoring, 1990, Volume: 12, Issue:2 Topics: Antibody Specificity; Bilirubin; Biotransformation; Cross Reactions; Digoxin; Evaluation Studies as Topic; Hemoglobins; Humans; Reagent Kits, Diagnostic; Spironolactone	1990
Reassessment of cross-reactivity of spironolactone metabolites with four digoxin immunoassays. Therapeutic drug monitoring, 1989, Volume: 11, Issue:2 Topics: Adult; Canrenone; Cross Reactions; Digoxin; Humans; Immunoassay; Immunoenzyme Techniques; Male; Radioimmunoassay; Spironolactone	1989
Interference of spironolactone metabolites in a digoxin radioimmunoassay. Therapeutic drug monitoring, 1989, Volume: 11, Issue:1 Topics: Digoxin; Humans; Radioimmunoassay; Spironolactone	1989
The effect of renal and hepatic impairment and of spironolactone on digoxin immunoassays. European journal of clinical pharmacology, 1988, Volume: 34, Issue:3 Topics: Aged; Aged, 80 and over; Digoxin; Female; Humans; Immunoassay; Kidney Diseases; Liver Diseases; Male; Middle Aged; Spironolactone	1988
Spironolactone as a source of interference in commercial digoxin immunoassays. Therapeutic drug monitoring, 1987, Volume: 9, Issue:2 Topics: Adult; Aged; Cross Reactions; Digoxin; Female; Humans; Male; Middle Aged; Radioimmunoassay; Spironolactone	1987
Interaction between digoxin and commonly coadministered drugs in children. Pediatrics, 1985, Volume: 75, Issue:6 Topics: Amiodarone; Child, Preschool; Digoxin; Drug Interactions; Drug Therapy, Combination; Humans; Infant; Infant, Newborn; Nifedipine; Quinidine; Spironolactone; Verapamil	1985
Effect of spironolactone on the renal clearance of digoxin in dogs. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:1 Topics: Aldosterone; Animals; Digoxin; Dogs; Inulin; Kidney; Metabolic Clearance Rate; Potassium; Quinidine; Sodium; Spironolactone	1985
Biological availability of drugs. Lancet (London, England), 1972, Jan-08, Volume: 1, Issue:7741 Topics: Biopharmaceutics; Chloramphenicol; Digoxin; Griseofulvin; Oxytetracycline; Phenindione; Spironolactone	1972
Effects of pretreatment with spironolactone on pharmacokinetics of 4'''-methyldigoxin in rats. Naunyn-Schmiedeberg's archives of pharmacology, 1973, Volume: 278, Issue:1 Topics: Animals; Bile; Dealkylation; Digoxin; Duodenum; Female; Half-Life; Injections; Liver; Rats; Spironolactone; Time Factors; Tritium	1973
Extrarenal actions of aldosterone antagonists in guinea pigs. II. Reduction of the toxicity of beta-methyl-digoxin. Naunyn-Schmiedeberg's archives of pharmacology, 1973, Volume: 279, Issue:1 Topics: Animals; Digoxin; Drug Interactions; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Spironolactone; Tritium	1973
Proceedings: The influence of spironolactone on the excretion and metabolism of 3H-digoxin in the rat. Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 282, Issue:Suppl Topics: Animals; Cardanolides; Chromatography, Paper; Chromatography, Thin Layer; Digoxin; Feces; Female; Male; Rats; Spironolactone; Stimulation, Chemical; Tritium	1974
Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides. The Journal of pharmacology and experimental therapeutics, 1974, Volume: 191, Issue:2 Topics: Analysis of Variance; Animals; Bile; Biotransformation; Cardiac Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Enzyme Induction; Lethal Dose 50; Liver; Male; Methylcholanthrene; Microsomes; Myocardium; Organ Size; Ouabain; Paralysis; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium; Zoxazolamine	1974
[Proceedings: Effect of potassium canrenoate (aldactone pro inj.) and digoxin on hemodynamics and infarct size in experimental myocardial infarct]. Zeitschrift fur Kardiologie, 1974, Volume: 0, Issue:Suppl 1 Topics: Animals; Blood Pressure; Cardiac Output; Digoxin; Dogs; Electrocardiography; Myocardial Infarction; Spironolactone	1974
Chronic vasodilator therapy in the management of cardiogenic shock and intractable left ventricular failure. Annals of internal medicine, 1974, Volume: 81, Issue:6 Topics: Blood Pressure; Cardiac Output; Digoxin; Drug Evaluation; Ferricyanides; Furosemide; Heart Failure; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide; Pulmonary Circulation; Shock, Cardiogenic; Spironolactone; Vasodilator Agents	1974
Effect of spironolactone on excretion of 3H-digoxin and its metabolites in rats. European journal of pharmacology, 1974, Volume: 29, Issue:1 Topics: Animals; Chloroform; Chromatography, Paper; Chromatography, Thin Layer; Digitoxigenin; Digoxin; Enzyme Induction; Feces; Female; Microsomes, Liver; Rats; Spironolactone; Time Factors; Tritium	1974
Heart failure and cardiac arrhythmias. The Practitioner, 1974, Volume: 213, Issue:1276 SPEC Topics: Arrhythmia, Sinus; Arrhythmias, Cardiac; Coronary Disease; Digoxin; Diuretics; Electroconvulsive Therapy; Endocarditis, Bacterial; Heart Aneurysm; Heart Failure; Heart Valve Diseases; Heart Ventricles; Humans; Lidocaine; Myocardial Infarction; Pacemaker, Artificial; Pericarditis, Constrictive; Potassium Deficiency; Rupture; Spironolactone; Tachycardia; Ventricular Fibrillation; Wolff-Parkinson-White Syndrome	1974
The effect of spironolactone and canrenone on the digoxin radioimmunoassay. Research communications in chemical pathology and pharmacology, 1974, Volume: 9, Issue:4 Topics: Animals; Antigen-Antibody Complex; Ascites; Charcoal; Digoxin; Half-Life; Humans; Immune Sera; Ketosteroids; Lactones; Pregnadienes; Rabbits; Radioimmunoassay; Sheep; Spironolactone; Tritium	1974
The improvement of specificity in radioimmunoassays. Clinica chimica acta; international journal of clinical chemistry, 1973, Mar-30, Volume: 44, Issue:3 Topics: Adsorption; Androstenes; Antigen-Antibody Complex; Cardanolides; Digitoxin; Digoxin; Immune Sera; Ketosteroids; Kinetics; Methods; Prednisolone; Prednisone; Radioimmunoassay; Spironolactone; Tritium	1973
Generic non-equivalence in cardiac practice. Indian heart journal, 1973, Volume: 25, Issue:1 Topics: Anticoagulants; Digoxin; Heart Diseases; Humans; Spironolactone; Therapeutic Equivalency	1973
[Clinical study on the subtoxic full effective and maintenance dose of digoxin under the influence of spironolactone. Studies on the decompensated heart patient]. Arzneimittel-Forschung, 1973, Volume: 23, Issue:4 Topics: Administration, Oral; Aged; Digoxin; Drug Tolerance; Female; Heart Failure; Humans; Magnesium; Male; Middle Aged; Potassium; Spironolactone	1973
H3-digitoxin and its metabolites following spironolactone pretreatment of rats. Research communications in chemical pathology and pharmacology, 1973, Volume: 6, Issue:2 Topics: Animals; Bile; Digitoxin; Digoxin; Feces; Liver; Male; Rats; Spironolactone; Tritium	1973
Muscle electrolytes and total exchangeable electrolytes in patients with cardiac diseases. Scandinavian journal of clinical and laboratory investigation, 1973, Volume: 32, Issue:2 Topics: Adult; Age Factors; Aortic Valve Stenosis; Body Water; Chlorides; Cytoplasm; Digoxin; Diuretics; Extracellular Space; Female; Heart Valve Diseases; Humans; Magnesium; Male; Middle Aged; Mitral Valve Stenosis; Muscles; Potassium; Radioisotopes; Sex Factors; Sodium; Spironolactone; Water-Electrolyte Balance	1973
Salivary electrolytes in digitalis-treated patients with and without raised aldosterone excretion. Klinische Wochenschrift, 1973, Dec-01, Volume: 51, Issue:23 Topics: Adult; Aged; Aldosterone; Calcium; Digoxin; Female; Heart Failure; Humans; Male; Middle Aged; Potassium; Radioimmunoassay; Saliva; Sodium; Spironolactone	1973
[Clinical experiences with the determination of the plasma digoxin level]. Nederlands tijdschrift voor geneeskunde, 1973, Dec-01, Volume: 117, Issue:48 Topics: Amniotic Fluid; Blood; Digoxin; False Positive Reactions; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Radioimmunoassay; Spironolactone; Tritium; Umbilical Cord	1973
Renal tubular secretion of digoxin. Circulation, 1974, Volume: 50, Issue:1 Topics: Adult; Aged; Digoxin; Female; Glomerular Filtration Rate; Heart Failure; Humans; Inulin; Kidney Tubules; Kidney Tubules, Distal; Male; Middle Aged; Protein Binding; Spironolactone	1974
[Digoxin incorporation into the cell]. Arzneimittel-Forschung, 1971, Volume: 21, Issue:6 Topics: Aldosterone; Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Digitoxin; Digoxin; In Vitro Techniques; Mice; Prednisolone; Spironolactone; Thyroid Hormones; Tritium	1971
[Effect of aldactone on the dynamics and contractility of the heart]. Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung, 1971, Volume: 37 Topics: Cardiac Catheterization; Digoxin; Heart; Hemodynamics; Humans; Mineralocorticoid Receptor Antagonists; Muscle Contraction; Spironolactone	1971
Effect of spironolactone and norbolethone on the toxicity of digitalis compounds in the rat. British journal of pharmacology, 1969, Volume: 37, Issue:2 Topics: Anabolic Agents; Animals; Cardanolides; Cardiac Glycosides; Digitalis Glycosides; Digitoxin; Digoxin; Female; Ouabain; Rats; Spironolactone; Strophanthins	1969
Heart failure. II. British medical journal, 1971, Mar-27, Volume: 1, Issue:5751 Topics: Aged; Aortic Valve Insufficiency; Digitoxin; Digoxin; Ethacrynic Acid; Female; Furosemide; Heart Failure; Humans; Male; Middle Aged; Mitral Valve Insufficiency; Oxygen Inhalation Therapy; Pulmonary Heart Disease; Spironolactone	1971
[Clinical experience with a new spironolactone-thiabuzide combination]. Medizinische Klinik, 1968, Jun-07, Volume: 63, Issue:23 Topics: Aged; Body Weight; Digoxin; Diuretics; Drug Synergism; Edema; Female; Furosemide; Glycosuria; Humans; Hypertension; Male; Middle Aged; Natriuresis; Potassium; Spironolactone; Strophanthins; Tolbutamide	1968
[The effects of digoxin, desoxycorticosterone and spironolactone on the myocardium of the mammal]. Archives internationales de pharmacodynamie et de therapie, 1967, Volume: 166, Issue:1 Topics: Animals; Calcium; Desoxycorticosterone; Digoxin; Drug Synergism; Guinea Pigs; Heart; Heart Atria; Potassium; Sodium; Spironolactone	1967
Failure of the aldosterone antagonist spironolactone to inhibit myocardial hypertrophy produced by experimental hyperthyroidism and accompanied by "apparent" digoxin immunoreactivity in the blood. Physiologia Bohemoslovaca, 1980, Volume: 29, Issue:6 Topics: Animals; Antigen-Antibody Reactions; Cardiomegaly; Digoxin; Heart; Hyperthyroidism; Male; Organ Size; Rats; Spironolactone; Thyroxine	1980
Congestive heart failure due to giant cutaneous cavernous hemangioma. Clinical pediatrics, 1984, Volume: 23, Issue:9 Topics: Digoxin; Drug Resistance; Facial Neoplasms; Female; Furosemide; Heart Failure; Hemangioma, Cavernous; Humans; Infant; Spironolactone	1984
[Heart failure therapy with digitalis and spironolactone--studies within the scope of preoperative treatment before lung resection]. Praxis und Klinik der Pneumologie, 1984, Volume: 38, Issue:9 Topics: Adult; Aged; Digitalis Glycosides; Digoxin; Drug Therapy, Combination; Female; Heart Failure; Hemodynamics; Humans; Lung Neoplasms; Male; Medigoxin; Middle Aged; Premedication; Spironolactone	1984
Spironolactone-digoxin interaction. Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1983, Volume: 82, Issue:1 Topics: Adult; Aged; Digoxin; Drug Interactions; Drug Therapy, Combination; Female; Heart Failure; Humans; Male; Middle Aged; Spironolactone	1983
Influence of spironolactone on serum digoxin concentration. JAMA, 1984, Jan-27, Volume: 251, Issue:4 Topics: Aged; Digoxin; Drug Interactions; Female; Humans; Spironolactone	1984
Digoxin-quinidine-spironolactone interaction. Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:1 Topics: Adult; Creatinine; Digoxin; Drug Interactions; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Quinidine; Spironolactone	1984
Interactions between digoxin and potassium-sparing diuretics. Clinical pharmacology and therapeutics, 1983, Volume: 33, Issue:4 Topics: Adult; Digoxin; Drug Interactions; Female; Glomerular Filtration Rate; Hemodynamics; Humans; Kidney; Kinetics; Male; Muscle Contraction; Spironolactone; Triamterene	1983
Drugs that increase the serum concentration of digoxin. The Journal of the Kansas Medical Society, 1983, Volume: 84, Issue:2 Topics: Anti-Bacterial Agents; Calcium Channel Blockers; Digoxin; Drug Interactions; Humans; Quinidine; Quinine; Spironolactone	1983
Beta-blockers in dilated cardiomyopathies: they work. European heart journal, 1983, Volume: 4 Suppl A Topics: Administration, Oral; Adult; Aged; Digoxin; Dilatation, Pathologic; Drug Therapy, Combination; Female; Follow-Up Studies; Furosemide; Heart Failure; Hemodynamics; Humans; Lactates; Male; Metoprolol; Middle Aged; Myocardium; Oxygen Consumption; Propanolamines; Spironolactone; Time Factors	1983
Pediatric clinical pharmacology of digoxin. Pediatric clinics of North America, 1981, Volume: 28, Issue:1 Topics: Adult; Child; Digoxin; Diuretics; Drug Interactions; Furosemide; Heart; Heart Diseases; Hemoperfusion; Humans; Infant; Infant, Newborn; Male; Myocardium; Oxygen Consumption; Quinidine; Spironolactone	1981
Spironolactone interference with digoxin radioimmunoassay in cirrhotic patients. American journal of hospital pharmacy, 1980, Volume: 37, Issue:11 Topics: Digoxin; Drug Interactions; Humans; Liver Cirrhosis; Radioimmunoassay; Serum Albumin; Spironolactone	1980
Comparison of methods for estimating digoxin dosing regimens: further analysis. American journal of hospital pharmacy, 1981, Volume: 38, Issue:10 Topics: Adult; Aged; Aging; Creatinine; Digoxin; Female; Humans; Kidney; Male; Middle Aged; Spironolactone	1981
Precision of digoxin radioimmunoassays and matrix effects: four kits compared. Clinical biochemistry, 1981, Volume: 14, Issue:2 Topics: Digoxin; False Positive Reactions; Humans; Hypertension; Myocardial Infarction; Radioimmunoassay; Reagent Kits, Diagnostic; Spironolactone; Uremia	1981
[Correlation of digoxin levels in the myocardium, plasma and saliva in patients under chronic treatment]. Archivos de farmacologia y toxicologia, 1981, Volume: 7, Issue:1 Topics: Adult; Aged; Atrial Fibrillation; Diazepam; Digoxin; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardium; Saliva; Spironolactone	1981
Glucuronidation of digitalis glycosides by rat liver microsomes: stimulation by spironolactone and pregnenolone-16 alpha-carbonitrile. Biochemical pharmacology, 1980, Jun-01, Volume: 29, Issue:11 Topics: Animals; Digitalis Glycosides; Digitoxin; Digoxigenin; Digoxin; Female; Glucuronates; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Spironolactone; Stimulation, Chemical	1980
Clinical studies on digoxin intoxication. I. Serum concentration of digoxin in the elderly and the effect of diuretics. Japanese heart journal, 1980, Volume: 21, Issue:3 Topics: Adult; Age Factors; Aged; Blood Urea Nitrogen; Creatinine; Digoxin; Diuretics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Furosemide; Heart Diseases; Humans; Male; Metabolic Clearance Rate; Middle Aged; Powders; Protein Binding; Spironolactone; Tablets	1980
Alteration of digoxin toxicity by 6-hydroxydopamine and soironolactone. Research communications in chemical pathology and pharmacology, 1980, Volume: 29, Issue:3 Topics: Animals; Digoxin; Dogs; Drug Interactions; Female; Heart; Hemodynamics; Hydroxydopamines; Male; Myocardial Contraction; Spironolactone; Sympathetic Nervous System	1980
[The effects of diphenylhydantoin and spironolactone on the digoxin pharmacokinetics in the rabbit (author's transl)]. Archivos de farmacologia y toxicologia, 1980, Volume: 6, Issue:2 Topics: Animals; Digoxin; Kinetics; Phenytoin; Rabbits; Radioimmunoassay; Spironolactone; Time Factors	1980
[Nonimmune fetal edema]. Revista medica de Panama, 1995, Volume: 20, Issue:3 Topics: Adult; Anemia, Macrocytic; Apgar Score; Cardiotonic Agents; Digoxin; Diuretics; Female; Humans; Hydrops Fetalis; Infant, Newborn; Male; Pregnancy; Pregnancy Complications, Hematologic; Spironolactone; Ultrasonography, Prenatal	1995
[Restrictive myocardiopathy in children. A study of 4 patients]. Anales espanoles de pediatria, 1996, Volume: 44, Issue:3 Topics: Cardiomyopathy, Restrictive; Cardiotonic Agents; Child; Child, Preschool; Digoxin; Diuretics; Drug Therapy, Combination; Fatal Outcome; Female; Furosemide; Humans; Infant; Male; Spironolactone	1996
A new interference in some digoxin assays: anti-murine heterophilic antibodies. Clinical pharmacology and therapeutics, 1996, Volume: 60, Issue:5 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Cardenolides; Digoxin; Diuretics; Drug Interactions; Drug Therapy, Combination; False Positive Reactions; Humans; Immunoenzyme Techniques; Male; Middle Aged; Saponins; Spironolactone	1996
[99mTc(V)-DMSA accumulation in gynecomastia]. Kaku igaku. The Japanese journal of nuclear medicine, 1998, Volume: 35, Issue:9 Topics: Digoxin; Furosemide; Gynecomastia; Humans; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Spironolactone; Technetium Tc 99m Dimercaptosuccinic Acid	1998
Drugs for chronic heart failure. The Medical letter on drugs and therapeutics, 1999, Jan-29, Volume: 41, Issue:1045 Topics: Adrenergic beta-Antagonists; Angioedema; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Chronic Disease; Digoxin; Diuretics; Dose-Response Relationship, Drug; Heart Failure; Humans; Hypokalemia; Hypotension; Spironolactone; Vasodilator Agents	1999
Population analysis for the optimization of digoxin treatment in Japanese paediatric patients. Journal of clinical pharmacy and therapeutics, 1999, Volume: 24, Issue:3 Topics: Age Factors; Body Weight; Cardiotonic Agents; Child; Child, Preschool; Digoxin; Drug Interactions; Female; Heart Failure; Humans; Infant; Infant, Newborn; Male; Sex Factors; Spironolactone	1999
Intoxication due to negative canrenone interference in digoxin drug monitoring. Lancet (London, England), 1999, Oct-02, Volume: 354, Issue:9185 Topics: Aged; Canrenone; Digoxin; Drug Interactions; Drug Monitoring; Enzyme Multiplied Immunoassay Technique; Fatal Outcome; Humans; Male; Medication Errors; Multiple Organ Failure; Sepsis; Spironolactone	1999
Spironolactone in patients with heart failure. The New England journal of medicine, 2000, Jan-13, Volume: 342, Issue:2 Topics: Angiotensin-Converting Enzyme Inhibitors; Digoxin; Diuretics; Drug Therapy, Combination; Furosemide; Heart Failure; Humans; Spironolactone	2000
Heart failure: highlights from new consensus guidelines. Cleveland Clinic journal of medicine, 2000, Volume: 67, Issue:1 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiotonic Agents; Digoxin; Diuretics; Echocardiography, Doppler; Heart Failure; Humans; Life Style; Mineralocorticoid Receptor Antagonists; Practice Guidelines as Topic; Spironolactone; Stroke Volume	2000
Overview of current chronic heart failure therapy. Journal of the Mississippi State Medical Association, 2000, Volume: 41, Issue:4 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Digoxin; Diuretics; Heart Failure; Humans; Mississippi; Spironolactone; Stroke Volume	2000
How many medicines do patients with heart failure need? Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Cytokines; Digoxin; Disease Models, Animal; Diuretics; Endothelins; Etanercept; Heart Failure; Humans; Immunoglobulin G; Immunosuppressive Agents; Mice; Mice, Transgenic; Neprilysin; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Spironolactone; Tumor Necrosis Factor-alpha	2001
Population-based investigation of relative clearance of digoxin in Japanese neonates and infants by multiple-trough screen analysis. European journal of clinical pharmacology, 2001, Volume: 57, Issue:1 Topics: Cardiotonic Agents; Chi-Square Distribution; Digoxin; Diuretics; Drug Monitoring; Female; Humans; Infant; Infant, Newborn; Japan; Male; Models, Biological; Regression Analysis; Reproducibility of Results; Spironolactone	2001
Digoxin assays: frequent, substantial, and potentially dangerous interference by spironolactone, canrenone, and other steroids. Clinical chemistry, 2002, Volume: 48, Issue:3 Topics: Anti-Arrhythmia Agents; Canrenone; Chromatography, High Pressure Liquid; Cross Reactions; Digoxin; Diuretics; Drug Interactions; False Negative Reactions; Humans; Immunoenzyme Techniques; In Vitro Techniques; Mineralocorticoid Receptor Antagonists; Prodrugs; Reagent Kits, Diagnostic; Spironolactone	2002
Bidirectional (positive/negative) interference of spironolactone, canrenone, and potassium canrenoate on serum digoxin measurement: elimination of interference by measuring free digoxin or using a chemiluminescent assay for digoxin. Journal of clinical laboratory analysis, 2002, Volume: 16, Issue:4 Topics: Canrenoic Acid; Canrenone; Cardiotonic Agents; Digoxin; Drug Interactions; Fluorescence Polarization Immunoassay; Humans; Luminescent Measurements; Mineralocorticoid Receptor Antagonists; Reproducibility of Results; Spironolactone	2002
Pharmacoepidemiologic detection of calcium channel blocker-induced change on digoxin clearance using multiple trough screen analysis. Biopharmaceutics & drug disposition, 2002, Volume: 23, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Calcium Channel Blockers; Creatinine; Digoxin; Diltiazem; Drug Interactions; Female; Heart Failure; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Models, Statistical; Nifedipine; Pharmacoepidemiology; Regression Analysis; Reproducibility of Results; Spironolactone; Verapamil	2002
Lack of clinically significant interference by spironolactone with the AxSym Digoxin II assay. Therapeutic drug monitoring, 2003, Volume: 25, Issue:1 Topics: Aged; Aged, 80 and over; Analysis of Variance; Confidence Intervals; Digoxin; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Spironolactone	2003
Ebstein's anomaly in a beagle dog. The Journal of veterinary medical science, 2003, Volume: 65, Issue:4 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bundle-Branch Block; Cardiotonic Agents; Diagnosis, Differential; Diet, Sodium-Restricted; Digoxin; Diuretics; Dogs; Drug Therapy, Combination; Ebstein Anomaly; Echocardiography; Electrocardiography; Enalapril; Fatal Outcome; Furosemide; Isosorbide Dinitrate; Male; Spironolactone; Vasodilator Agents	2003
A new turbidometric digoxin immunoassay on the ADVIA 1650 analyzer is free from interference by spironolactone, potassium canrenoate, and their common metabolite canrenone. Therapeutic drug monitoring, 2003, Volume: 25, Issue:4 Topics: Canrenoic Acid; Canrenone; Cardiotonic Agents; Cross Reactions; Digoxin; Drug Interactions; Fluorescence Polarization Immunoassay; Humans; Spironolactone	2003
"Lack of clinically significant interference by spironolactone with the Axsym Digoxin II assay" only applies to low-dose therapy with spironolactone. Therapeutic drug monitoring, 2003, Volume: 25, Issue:4 Topics: Cardiotonic Agents; Cross Reactions; Digoxin; Dose-Response Relationship, Drug; Drug Interactions; Humans; Immunoenzyme Techniques; Mineralocorticoid Receptor Antagonists; Spironolactone	2003
Management of chronic heart failure due to systolic left ventricular dysfunction by cardiologist and non-cardiologist physicians. European journal of heart failure, 2003, Volume: 5, Issue:4 Topics: Aged; Cardiology; Chronic Disease; Digoxin; Diuretics; Female; Guideline Adherence; Heart Failure; Hospitalization; Humans; Male; Practice Guidelines as Topic; Practice Patterns, Physicians'; Spironolactone; Ventricular Dysfunction, Left	2003
PERIODIC PARALYSIS. The American journal of medicine, 1965, Volume: 39 Topics: Adolescent; Chlorides; Cortisone; Diet Therapy; Diet, Sodium-Restricted; Digoxin; Drug Therapy; Genetics, Medical; Glucose; Humans; Hypokalemia; Insulin; Paralyses, Familial Periodic; Paralysis; Periodicity; Phosphates; Potassium; Prednisone; Sodium; Sodium, Dietary; Spironolactone; Urine; Water-Electrolyte Balance	1965
The African-American Heart Failure Trial (A-HeFT): rationale and methodology. Journal of cardiac failure, 2003, Volume: 9, Issue:5 Suppl Ni Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Black or African American; Digoxin; Diuretics; Drug Therapy, Combination; Ethnicity; Female; Heart Failure; Heart Transplantation; Humans; Male; Middle Aged; Patient Selection; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Spironolactone; Ventricular Dysfunction, Left	2003
[Idiopathic hypereosinophilia with cardiac involvement]. Deutsche medizinische Wochenschrift (1946), 2004, Mar-12, Volume: 129, Issue:11 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Cardiomyopathy, Restrictive; Cardiotonic Agents; Diagnosis, Differential; Digoxin; Diuretics; Drug Therapy, Combination; Echocardiography, Doppler; Enalapril; Endomyocardial Fibrosis; Female; Humans; Hypereosinophilic Syndrome; Magnetic Resonance Imaging; Mineralocorticoid Receptor Antagonists; Mitral Valve Insufficiency; Patient Compliance; Prognosis; Spironolactone; Sulfonamides; Torsemide	2004
Factors influencing medical treatment of heart failure patients in Spanish internal medicine departments: a national survey. QJM : monthly journal of the Association of Physicians, 2005, Volume: 98, Issue:2 Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Ambulatory Care; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Cardiac Glycosides; Cardiotonic Agents; Cross-Sectional Studies; Digoxin; Diuretics; Female; Heart Failure; Hospitalization; Humans; Male; Middle Aged; Nitrates; Prospective Studies; Spironolactone	2005
Pharmacological treatment of congestive heart failure in Canada: a description of care in five provinces. The Canadian journal of cardiology, 2005, Mar-15, Volume: 21, Issue:4 Topics: Adrenergic beta-Antagonists; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Canada; Cardiotonic Agents; Digoxin; Diuretics; Drug Utilization; Heart Failure; Humans; Spironolactone	2005
Economic implications of treatment guidelines for congestive heart failure. The Canadian journal of cardiology, 2005, Volume: 21, Issue:14 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Canada; Databases as Topic; Digoxin; Drug Costs; Drug Utilization Review; Guideline Adherence; Heart Failure; Hospital Costs; Hospitalization; Humans; Practice Guidelines as Topic; Spironolactone	2005
Induction of rat intestinal P-glycoprotein by spironolactone and its effect on absorption of orally administered digoxin. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:3 Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Digoxin; Drug Interactions; Intestinal Absorption; Intestinal Mucosa; Male; Rats; Rats, Wistar; Spironolactone	2006
Flexible versus nonflexible mitral valve rings for congestive heart failure: differential durability of repair. Circulation, 2006, Jul-04, Volume: 114, Issue:1 Suppl Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Cardiomyopathy, Dilated; Combined Modality Therapy; Databases, Factual; Digoxin; Diuretics; Drug Therapy, Combination; Equipment Design; Female; Follow-Up Studies; Heart Failure; Heart Ventricles; Heart-Assist Devices; Humans; Male; Middle Aged; Milrinone; Mitral Valve; Mitral Valve Insufficiency; Norepinephrine; Pliability; Postoperative Complications; Prospective Studies; Recurrence; Reoperation; Spironolactone; Stroke Volume; Time Factors; Tricuspid Valve Insufficiency; Ultrasonography	2006
A new enzyme-linked chemiluminescent immunosorbent digoxin assay is virtually free from interference of spironolactone, potassium canrenoate, and their common metabolite canrenone. Journal of clinical laboratory analysis, 2006, Volume: 20, Issue:5 Topics: Artifacts; Canrenone; Cross Reactions; Digoxin; Enzyme-Linked Immunosorbent Assay; Fluorescence Polarization Immunoassay; Humans; Luminescent Measurements; Nephelometry and Turbidimetry; Reagent Kits, Diagnostic; Sensitivity and Specificity; Spironolactone	2006
Comparison of one-year outcome (death and rehospitalization) in hospitalized heart failure patients with left ventricular ejection fraction >50% versus those with ejection fraction <50%. The American journal of cardiology, 2008, Jul-01, Volume: 102, Issue:1 Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Cardiotonic Agents; Digoxin; Diuretics; Female; Heart Failure; Hospitalization; Humans; Male; Middle Aged; Patient Readmission; Spironolactone; Stroke Volume; Time Factors; Treatment Outcome; Ultrasonography	2008
Description of a chronic heart failure service model and review of pharmacotherapy in a district general hospital in comparison to Scottish Intercollegiate Guideline Network (SIGN) guidelines. Scottish medical journal, 2008, Volume: 53, Issue:3 Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cardiotonic Agents; Digoxin; Disease Management; Diuretics; Heart Failure, Systolic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Medical Audit; Outpatient Clinics, Hospital; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prospective Studies; Retrospective Studies; Scotland; Spironolactone	2008
Effect of spironolactone, potassium canrenoate and their common metabolite canrenone on serum digoxin measurement by digoxin III, a new digoxin immunoassay. Therapeutic drug monitoring, 2008, Volume: 30, Issue:6 Topics: Canrenoic Acid; Canrenone; Cross Reactions; Digoxin; Drug Interactions; Humans; Immunoassay; Mineralocorticoid Receptor Antagonists; Spironolactone	2008
Isolated left ventricular hypertrabeculation/noncompaction in a Turner mosaic with male phenotype. Acta cardiologica, 2009, Volume: 64, Issue:1 Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Carbazoles; Cardiomyopathy, Dilated; Cardiotonic Agents; Carvedilol; Digoxin; Diuretics; Echocardiography; Furosemide; Heart Ventricles; Humans; Lisinopril; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Mosaicism; Phenotype; Propanolamines; Spironolactone; Turner Syndrome; Ventricular Dysfunction, Left	2009
[A mourning case that referred with sexual identity disorder secondary to a general medical condition]. Turk psikiyatri dergisi = Turkish journal of psychiatry, 2009,Summer, Volume: 20, Issue:2 Topics: Bereavement; Depression; Digoxin; Erectile Dysfunction; Female; Gender Identity; Gynecomastia; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Spironolactone	2009
Complications during enalapril and diuretic therapy for congestive cardiac failure. Indian journal of pediatrics, 2009, Volume: 76, Issue:9 Topics: Angiotensin-Converting Enzyme Inhibitors; Cardiotonic Agents; Digoxin; Diuretics; Drug Therapy, Combination; Electrocardiography; Enalapril; Furosemide; Heart Failure; Humans; Infant; Male; Spironolactone	2009
Interference between eplerenone and digoxin in fluorescence polarization immunoassay, microparticle enzyme immunoassay, and affinity column-mediated immunoassay. Therapeutic drug monitoring, 2010, Volume: 32, Issue:6 Topics: Anti-Arrhythmia Agents; Antibodies; Cross Reactions; Digoxin; Eplerenone; Fluorescence Polarization Immunoassay; Humans; Immunoassay; In Vitro Techniques; Mineralocorticoid Receptor Antagonists; Spironolactone	2010
[Application of cardiac resynchronization therapy and ivabradine in a patient with chronic heart failure]. Kardiologiia, 2010, Volume: 50, Issue:7 Topics: Benzazepines; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiovascular Agents; Digoxin; Diuretics; Echocardiography; Electrocardiography; Furosemide; Heart Atria; Heart Failure; Heart Rate; Heart Ventricles; Humans; Ivabradine; Male; Middle Aged; Myocardial Infarction; Spironolactone; Treatment Outcome	2010
Abbott ARCHITECT clinical chemistry and immunoassay systems: digoxin assays are free of interferences from spironolactone, potassium canrenoate, and their common metabolite canrenone. Therapeutic drug monitoring, 2011, Volume: 33, Issue:1 Topics: Anti-Arrhythmia Agents; Canrenoic Acid; Canrenone; Chemistry, Clinical; Cross Reactions; Digoxin; Immunoassay; Mineralocorticoid Receptor Antagonists; Spironolactone	2011
Effect of spironolactone, potassium canrenoate, and their common metabolite canrenone on Dimension Vista Digoxin Assay. Journal of clinical laboratory analysis, 2010, Volume: 24, Issue:6 Topics: Biological Assay; Canrenoic Acid; Canrenone; Cardiotonic Agents; Chemistry, Clinical; Cross Reactions; Digoxin; Drug Interactions; Drug Monitoring; Humans; Immunoassay; Mineralocorticoid Receptor Antagonists; Osmolar Concentration; Reagent Kits, Diagnostic; Spironolactone	2010
Time-trends in treatment and cardiovascular events in patients with heart failure: a pharmacosurveillance study. European journal of heart failure, 2011, Volume: 13, Issue:5 Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Cardiotonic Agents; Digoxin; Diuretics; Female; Heart Failure; Hospitalization; Humans; Male; Myocardial Infarction; Myocardial Ischemia; Practice Patterns, Physicians'; Prognosis; Spironolactone; Stroke	2011
Clinically insignificant negative interferences of spironolactone, potassium canrenoate, and their common metabolite canrenone in new dimension vista LOCI digoxin immunoassay. Journal of clinical laboratory analysis, 2012, Volume: 26, Issue:3 Topics: Canrenoic Acid; Canrenone; Digoxin; Humans; Immunoassay; Luminescent Measurements; Models, Molecular; Spironolactone	2012
Use of different parameters and equations for calculation of IC₅₀ values in efflux assays: potential sources of variability in IC₅₀ determination. The AAPS journal, 2014, Volume: 16, Issue:1 Topics: Algorithms; Caco-2 Cells; Cardiotonic Agents; Digoxin; Drug Interactions; Humans; Imidazoles; Inhibitory Concentration 50; Itraconazole; Piperazines; Spironolactone; Sulfones; Triazines; Vardenafil Dihydrochloride	2014
Developing a list of high-alert medications for patients with chronic diseases. European journal of internal medicine, 2014, Volume: 25, Issue:10 Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Amiodarone; Analgesics, Opioid; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Cytostatic Agents; Digoxin; Dronedarone; Drug-Related Side Effects and Adverse Reactions; Eplerenone; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Insulin; Methotrexate; Mineralocorticoid Receptor Antagonists; Platelet Aggregation Inhibitors; Sodium Potassium Chloride Symporter Inhibitors; Spironolactone	2014
Cardiovascular medication utilization and adherence among heart failure patients in rural and urban areas: a retrospective cohort study. The Canadian journal of cardiology, 2015, Volume: 31, Issue:3 Topics: Adrenergic Antagonists; Aged; Aged, 80 and over; Canada; Cardiotonic Agents; Cardiovascular Agents; Digoxin; Diuretics; Female; Follow-Up Studies; Heart Failure; Humans; Male; Medication Adherence; Renin-Angiotensin System; Retrospective Studies; Rural Population; Spironolactone; Treatment Outcome; Urban Population	2015
Drug dosage adjustment in hospitalized patients with renal impairment at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia. BMC nephrology, 2015, Oct-07, Volume: 16 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Anti-Ulcer Agents; Antifungal Agents; Antihypertensive Agents; Ceftazidime; Cimetidine; Creatinine; Cross-Sectional Studies; Digoxin; Diuretics; Drug Dosage Calculations; Drug Prescriptions; Enalapril; Ethiopia; Female; Fluconazole; Gout Suppressants; Hospitalization; Humans; Male; Medication Errors; Middle Aged; Pharmaceutical Preparations; Prospective Studies; Renal Insufficiency, Chronic; Severity of Illness Index; Spironolactone; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin; Young Adult	2015
Clinical and echocardiographic characteristics and outcomes in congestive heart failure at the Hospital of The State University of Haiti. American heart journal, 2016, Volume: 178 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Age Distribution; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Carbazoles; Cardiomyopathy, Dilated; Cardiotonic Agents; Carvedilol; Cohort Studies; Digoxin; Diuretics; Echocardiography; Electrocardiography; Female; Furosemide; Haiti; Heart Failure; Hospitalization; Hospitals, University; Hospitals, Urban; Humans; Hypertension; Male; Middle Aged; Pregnancy; Pregnancy Complications, Cardiovascular; Propanolamines; Prospective Studies; Puerperal Disorders; Sex Distribution; Spironolactone; Stroke Volume; Young Adult	2016
[Analysis of the mitochondrial function and ultrastructure in healthy albino mice treated with heart failure medications] Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina), 2017, 09-08, Volume: 74, Issue:3 Topics: Animals; Antihypertensive Agents; Atenolol; Cardiotonic Agents; Digoxin; Disease Models, Animal; Diuretics; Electrocardiography; Enalapril; Female; Furosemide; Heart Failure; Isosorbide Dinitrate; Male; Mice; Mitochondria, Heart; Spironolactone	2017
Risk of renal dysfunction in an elderly patient with chronic heart failure. Medizinische Monatsschrift fur Pharmazeuten, 2016, Volume: 39, Issue:10 Topics: Aged, 80 and over; Atrial Fibrillation; Carbazoles; Carvedilol; Diclofenac; Digoxin; Drug Interactions; Drug Therapy, Combination; Female; Heart Failure; Humans; Hypertension; Kidney Failure, Chronic; Myocardial Infarction; Potassium; Potentially Inappropriate Medication List; Propanolamines; Ramipril; Risk Factors; Spironolactone	2016
Impact of SLCO4C1 Genotypes, Creatinine, and Spironolactone on Digoxin Population Pharmacokinetic Variables in Patients With Cardiac Insufficiency. Clinical therapeutics, 2020, Volume: 42, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Creatinine; Digoxin; Drug Monitoring; Female; Genotype; Heart Failure; Humans; Male; Middle Aged; Models, Biological; Organic Anion Transporters; Retrospective Studies; Spironolactone; Young Adult	2020
Impact of SLCO4C1 Genotypes, Creatinine, and Spironolactone on Digoxin Population Pharmacokinetic Variables in Patients With Cardiac Insufficiency. Clinical therapeutics, 2021, Volume: 43, Issue:4 Topics: Creatinine; Digoxin; Genotype; Heart Failure; Humans; Organic Anion Transporters; Spironolactone	2021
The Impact of Procyanidin Extracted from Crataegus azarolus on Rats with Induced Heart Failure. Cellular and molecular biology (Noisy-le-Grand, France), 2022, Sep-30, Volume: 68, Issue:9 Topics: Animals; Biomarkers; Crataegus; Digoxin; Heart Failure; Male; Natriuretic Peptide, Brain; Peptide Fragments; Proanthocyanidins; Rats; Spironolactone	2022