spironolactone has been researched along with digitoxin in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 52 (91.23) | 18.7374 |
| 1990's | 1 (1.75) | 18.2507 |
| 2000's | 2 (3.51) | 29.6817 |
| 2010's | 2 (3.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Castle, MC | 2 |
| Loriaux, DL; Pita, JC; Rifka, SM; Vigersky, RA; Wilson, YA | 1 |
| Lippman, ME; Loriaux, DL; Pita, JC; Thompson, EB | 1 |
| Wachter, C; Wood, WG | 1 |
| Schmoldt, A | 1 |
| Boink, AB; Kruyswijk, HH; Maas, AH; Willebrands, AF | 1 |
| Falkner, FC; Frölich, JC; Hollifield, JW; Oates, JA; Sweetman, BS; Wirth, KE | 1 |
| Rietbrock, N; VOHRINGER, HF; Weller, L | 1 |
| Rietbrock, N; Vöhringer, HF | 1 |
| Cacini, W; Wernke, MJ | 1 |
| Blakemore, WS; Thind, GS; Zinsser, HF | 1 |
| Selye, H; Szabo, S; Taché, Y | 1 |
| Stolpmann, HJ; Vöhringer, HF | 1 |
| Mécs, I; Selye, H | 1 |
| Selye, H | 4 |
| Klaassen, CD | 1 |
| Krajny, M; Solymoss, B; Toth, S; Varga, S | 1 |
| Castle, MC; Lage, GL | 3 |
| Phillips, AP | 1 |
| Stohs, SJ; Talcott, RE | 1 |
| Carpi, A; Chiavarelli, R; Del Basso, P | 1 |
| Blascheck, JA; Gardell, C; Kovacs, K | 1 |
| Szabó, S | 1 |
| Mécs, I; Selye, H; Szabo, S | 1 |
| Hüsten, J; Ruiz-Torres, A | 1 |
| Buck, SH; Lage, GL | 1 |
| Jelinek, J; Krajny, M; Selye, H | 1 |
| Mécs, I; Selye, H; Tamura, T | 1 |
| Kleiman, B; Krajny, M; Savoie, L | 1 |
| Selye, H; Solymoss, B; Toth, S; Varga, S | 1 |
| Krajny, M; Savoie, L; Selye, H | 1 |
| Abbas-Ali, B; Bergs, C; Heinemeyer, G; Hildebrandt, AG; Roots, I; Schlede, E; Schmoldt, A | 1 |
| Sato, T | 1 |
| Kitani, K; Ohta, M; Sato, Y | 1 |
| Lage, GL; Volp, RF | 1 |
| Kanai, S; Kitani, K; Nokubo, M; Sato, Y | 1 |
| Carruthers, SG; Dujovne, CA | 1 |
| Epping, J; Fuchshofen, M; Richter, E | 1 |
| IMAI, S; KATORI, M; MURASE, H; OKADA, M; SHIGEI, T | 1 |
| Voudoukis, IJ | 1 |
| Olesen, KH; Valentin, N | 1 |
| Pabst, K | 1 |
| LeWinn, EB | 1 |
| Kley, HK | 1 |
| Daum, S; Goerg, R; Schlehe, H; Wang, D | 1 |
| Klüsener, W; Sabin, G | 1 |
| Opasich, C | 1 |
| Bilińska, ZT; Czajkowski, K; Dangel, J; Demkow, M; Dzielińska, Z; Konka, M; Kryczka, K; Przybylski, A; Różański, J; Szczudlik, J | 1 |
2 review(s) available for spironolactone and digitoxin
| Article | Year |
|---|---|
[Clinical pharmacology of digitalis glycosides].
Topics: Digitalis Glycosides; Digitoxin; Digoxin; Drug Interactions; Furosemide; Humans; Kinetics; Quinidine; Spironolactone; Vasodilator Agents | 1982 |
The steroidal actions of digitalis.
Topics: Animals; Cardiotonic Agents; Digitalis; Digitoxigenin; Digoxigenin; Estradiol; Estrogens; Female; Gonadal Steroid Hormones; Humans; Male; Plants, Medicinal; Plants, Toxic; Spironolactone; Steroids; Structure-Activity Relationship | 1984 |
1 trial(s) available for spironolactone and digitoxin
| Article | Year |
|---|---|
[Blocking of aldosterone receptors reduces the risk of events in patients with severe cardiac failure].
Topics: Angiotensin-Converting Enzyme Inhibitors; Digitalis; Diuretics; Double-Blind Method; Drug Therapy, Combination; Follow-Up Studies; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Plants, Medicinal; Plants, Toxic; Risk Factors; Spironolactone; Time Factors | 2000 |
54 other study(ies) available for spironolactone and digitoxin
| Article | Year |
|---|---|
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Digitoxin metabolism by rat liver homogenates, subcellular fractions and isolated hepatocytes: stimulation by spironolactone and pregnenolone-16 alpha-carbonitrile.
Topics: Animals; Biotransformation; Digitoxin; In Vitro Techniques; Liver; Male; Microsomes, Liver; NAD; NADP; Pregnenolone Carbonitrile; Rats; Spironolactone; Subcellular Fractions | 1979 |
Interaction of digitalis and spironolactone with human sex steroid receptors.
Topics: Binding, Competitive; Digitoxin; Estradiol; Female; Humans; Infant, Newborn; Male; Menopause; Penis; Prostatic Hyperplasia; Receptors, Androgen; Receptors, Estrogen; Receptors, Steroid; Sex Hormone-Binding Globulin; Spironolactone; Uterus | 1978 |
Interaction of spironolactone and digitalis with the 5 alpha-dihydrotestosterone (DHT) receptor of rat ventral prostate.
Topics: Animals; Binding Sites; Cytosol; Digitalis Glycosides; Digitoxin; Digoxin; Dihydrotestosterone; Male; Prostate; Rats; Receptors, Cell Surface; Spironolactone | 1975 |
A critical appraisal of a further three new commercial digoxin radioimmunoassay kits with reference to cross-reacting substances.
Topics: Blood Proteins; Canrenone; Cross Reactions; Digitoxin; Digoxin; Evaluation Studies as Topic; Furosemide; Humans; Radioimmunoassay; Reagent Kits, Diagnostic; Spironolactone | 1979 |
Increased digitoxin cleavage by liver microsomes of spironolactone-pretreated rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Digitoxin; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Spironolactone; Time Factors | 1978 |
Some factors affecting a commercial kit for radioimmunoassay of digoxin using tritiated digoxin.
Topics: Amniotic Fluid; Chemical Phenomena; Chemistry; Cross Reactions; Digitoxin; Digoxin; Ethanol; Female; Fetal Blood; Humans; Male; Polygeline; Pregnancy; Radioimmunoassay; Spironolactone | 1977 |
Metabolism of digitoxin in man and its modification by spironolactone.
Topics: Aged; Chromatography, Paper; Chromatography, Thin Layer; Digitoxin; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Mass Spectrometry; Metabolic Clearance Rate; Middle Aged; Spironolactone | 1976 |
Influence of spironolactone pretreatment on pharmacokinetics and metabolism of digitoxin in rats.
Topics: Animals; Chloroform; Chromatography, Thin Layer; Digitoxigenin; Digitoxin; Digoxin; Drug Interactions; Female; Glucuronates; Half-Life; Hydroxylation; Kinetics; Liver; Rats; Solubility; Spironolactone; Tritium | 1975 |
Proceedings: Pharmacokinetics of digitoxin in rats after pretreatment with spironolactone.
Topics: Animals; Digitoxin; Female; Kinetics; Rats; Spironolactone; Time Factors | 1975 |
Concentrative uptake of digoxin by slices of chicken renal cortex.
Topics: Animals; Chickens; Digitoxin; Digoxigenin; Digoxin; Female; Hexoses; Kidney Cortex; Kinetics; Ouabain; Potassium; Probenecid; Quinine; Sodium Cyanide; Spironolactone | 1990 |
Direct current cardioversion in digitalized patients with mitral valve disease.
Topics: Adult; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Bradycardia; Cardiac Complexes, Premature; Digitoxin; Electric Countershock; Electrocardiography; Electrolytes; Embolism; Female; Heart Failure; Heart Septal Defects, Atrial; Heparin; Humans; Hypokalemia; Intracranial Embolism and Thrombosis; Male; Middle Aged; Mitral Valve Stenosis; Postoperative Complications; Pulmonary Embolism; Quinidine; Spironolactone; Water-Electrolyte Balance | 1969 |
Interruption of pregnancy by various steroids.
Topics: Abortion, Induced; Anabolic Agents; Animals; Cholesterol; Dehydroepiandrosterone; Dexamethasone; Digitoxin; Estradiol; Ethylestrenol; Female; Indomethacin; Oxandrolone; Phenobarbital; Prednisolone; Pregnancy; Pregnenolone; Progesterone; Rats; Spironolactone; Steroids; Triamcinolone | 1971 |
Proceedings: Influence of spironolactone pretreatment on pharmakokinetics and metabolism of digitoxin in the rat.
Topics: Animals; Cardiac Glycosides; Chromatography, Thin Layer; Digitoxin; Feces; Half-Life; Hydroxylation; Kinetics; Rats; Spironolactone; Tritium | 1974 |
Blockade of catatoxic steroid actions by metyrapone.
Topics: Adrenocorticotropic Hormone; Animals; Digitoxin; Female; Indomethacin; Metyrapone; Peptic Ulcer; Rats; Spironolactone | 1970 |
Prevention of various forms of metabolic myocardial necrosis by catatoxic steroids.
Topics: Animals; Cardiomyopathies; Desoxycorticosterone; Digitoxin; Disease Models, Animal; Ethylestrenol; Female; Fludrocortisone; Myocardial Infarction; Necrosis; Norsteroids; Oxandrolone; Perchlorates; Prednisolone; Progesterone; Rats; Sodium; Spironolactone; Steroids; Triamcinolone | 1970 |
Spironolactone actions, independent of mineralocorticoid blockade.
Topics: Anesthetics; Animals; Depression, Chemical; Desoxycorticosterone; Digitoxin; Electrolytes; Female; Kidney; Nephrectomy; Pregnanediones; Progesterone; Rats; Spironolactone | 1969 |
[Anticatatoxic hormones].
Topics: Animals; Desoxycorticosterone; Digitoxin; Drug Antagonism; Drug Synergism; Estradiol; Female; Glucocorticoids; Indomethacin; Mineralocorticoids; Nitriles; Pregnanediones; Pregnenolone; Progesterone; Rats; Rats, Inbred Strains; Spironolactone; Thyroxine; Triamcinolone | 1972 |
Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.
Topics: Analysis of Variance; Animals; Bile; Biotransformation; Cardiac Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Enzyme Induction; Lethal Dose 50; Liver; Male; Methylcholanthrene; Microsomes; Myocardium; Organ Size; Ouabain; Paralysis; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium; Zoxazolamine | 1974 |
Influence of spironolactone and other steroids on the plasma level of digitoxin.
Topics: Animals; Cycloheximide; Digitoxin; Ethylestrenol; Female; Norpregnenes; Proadifen; Rats; Spironolactone; Time Factors | 1972 |
Enhanced biliary excretion of digitoxin following sprionolactone as it relates to the prevention of digitoxin toxicity.
Topics: Animals; Bile; Digitoxin; Kinetics; Male; Rats; Spironolactone; Time Factors; Tritium | 1973 |
The improvement of specificity in radioimmunoassays.
Topics: Adsorption; Androstenes; Antigen-Antibody Complex; Cardanolides; Digitoxin; Digoxin; Immune Sera; Ketosteroids; Kinetics; Methods; Prednisolone; Prednisone; Radioimmunoassay; Spironolactone; Tritium | 1973 |
Effect of phenobarbital and spironolactone pretreatment on digitoxin-induced mortality in male and female rats.
Topics: Animals; Digitoxin; Drug Interactions; Female; Male; Phenobarbital; Rats; Spironolactone; Tritium | 1973 |
H3-digitoxin and its metabolites following spironolactone pretreatment of rats.
Topics: Animals; Bile; Digitoxin; Digoxin; Feces; Liver; Male; Rats; Spironolactone; Tritium | 1973 |
[Digitoxin toxicity: interaction with carinamide, clofibrate and spironolactone].
Topics: Animals; Benzoates; Benzyl Compounds; Central Nervous System; Clofibrate; Digitoxin; Drug Interactions; Guinea Pigs; Protein Binding; Spironolactone; Sulfonamides | 1973 |
[Spironolactone protection against experimental cardiopathy due to digitoxin, disodium phosphate and oil].
Topics: Animals; Cardiomyopathies; Digitoxin; Enzyme Induction; Heart; Microscopy, Electron; Myocardium; Necrosis; Oils; Phosphates; Rats; Sodium; Spironolactone | 1970 |
Effect of pretreatment with spironolactone, phenobarbital or -diethylaminoethyl diphenylpropylacetate (SKF 525-A) on tritium levels in blood, heart and liver of rats at various times after administration of ( 3 H)digitoxin.
Topics: Animals; Depression, Chemical; Digitoxin; Kinetics; Liver; Male; Myocardium; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Spironolactone; Stimulation, Chemical; Tritium | 1972 |
[Catatoxic steroids].
Topics: Animals; Barbiturates; Digitoxin; Ethisterone; Humans; Insecticides; Poisoning; Rats; Spironolactone; Steroids | 1972 |
Protection by catatoxic steroids and related compounds against proscillaridin intoxication.
Topics: Anabolic Agents; Androstanes; Animals; Bufanolides; Digitoxin; Ethylestrenol; Female; Glucocorticoids; Hydroxysteroids; Ketosteroids; Phenobarbital; Pregnanes; Pregnenolone; Propionates; Rats; Rats, Inbred Strains; Seizures; Spironolactone; Thyroxine | 1972 |
[Digoxin incorporation into the cell].
Topics: Aldosterone; Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Digitoxin; Digoxin; In Vitro Techniques; Mice; Prednisolone; Spironolactone; Thyroid Hormones; Tritium | 1971 |
Possible mechanism of the prevention of digitoxin toxicity by spironolactone in the mouse.
Topics: Animals; Digitoxin; Drug Antagonism; Enzyme Induction; Liver; Male; Mice; Paralysis; Pentobarbital; Seizures; Sleep; Spironolactone; Time Factors; Zoxazolamine | 1971 |
Effect of catatoxic steroids upon established morbid changes.
Topics: Animals; Digitoxin; Female; Indomethacin; Intestine, Small; Nitriles; Peritonitis; Poisoning; Pregnenolone; Rats; Seizures; Spironolactone | 1971 |
Prevention of digitoxin poisoning by various steroids.
Topics: Anabolic Agents; Androstanes; Animals; Body Weight; Desoxycorticosterone; Digitoxin; Diuretics; Estradiol; Ethisterone; Ethylestrenol; Female; Fluoxymesterone; Hydrocortisone; Ketones; Methyltestosterone; Nandrolone; Norethandrolone; Norethynodrel; Organ Size; Oxandrolone; Oxymetholone; Poisoning; Pregnanes; Pregnenolone; Progesterone; Pyrazines; Rats; Spironolactone; Testosterone; Triamterene | 1969 |
Effect of spironolactone and norbolethone on the toxicity of digitalis compounds in the rat.
Topics: Anabolic Agents; Animals; Cardanolides; Cardiac Glycosides; Digitalis Glycosides; Digitoxin; Digoxin; Female; Ouabain; Rats; Spironolactone; Strophanthins | 1969 |
Digitoxin induced cardiac necrosis and its inhibition.
Topics: Animals; Cardiomyopathies; Digitoxin; Drug Synergism; Enzyme Induction; Female; Heart; Injections, Subcutaneous; Liver; Myocardial Infarction; Myocardium; Necrosis; Phosphates; Rats; Spironolactone; Triamterene | 1969 |
Heart failure. II.
Topics: Aged; Aortic Valve Insufficiency; Digitoxin; Digoxin; Ethacrynic Acid; Female; Furosemide; Heart Failure; Humans; Male; Middle Aged; Mitral Valve Insufficiency; Oxygen Inhalation Therapy; Pulmonary Heart Disease; Spironolactone | 1971 |
Protection by spironolactone and oxandrolone against chronic digitoxin or indomethacin intoxication.
Topics: Animals; Digitoxin; Drug Antagonism; Female; Indomethacin; Intestinal Diseases; Jejunum; Microsomes, Liver; Mortality; Oxandrolone; Proadifen; Rats; Seizures; Spironolactone; Ulcer | 1971 |
Digitoxin poisoning: prevention by spironolactone.
Topics: Animals; Digitoxin; Female; Heart; Rats; Spironolactone | 1969 |
Studies on the mechanism of stimulation of microsomal H2O2 formation and benzo(a)pyrene hydroxylation by substrates and flavone.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Catalase; Digitoxin; Hexobarbital; Hydrogen Peroxide; Kinetics; Male; Methanol; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Propranolol; Rabbits; Rats; Spironolactone | 1981 |
The effect of spironolactone pretreatment on digitoxin metabolism in isolated hepatocytes from male and female rats.
Topics: Animals; Cells, Cultured; Digitoxin; Female; In Vitro Techniques; Kinetics; Liver; Male; Rats; Sex Factors; Spironolactone | 1982 |
Digitoxin metabolism by rat, mouse, and rabbit: NADPH requirement and spironolactone effect.
Topics: Animals; Digitoxin; Male; Mice; Mice, Inbred Strains; NADP; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Spironolactone | 1982 |
The effect of spironolactone pretreatment on the biliary excretion of digitoxin and its metabolites in male and female rats.
Topics: Animals; Bile; Biotransformation; Cytochrome P-450 Enzyme System; Digitoxin; Female; Hydroxylation; Liver; Male; Rats; Rats, Inbred Strains; Sex Factors; Spironolactone | 1982 |
Cholestyramine and spironolactone and their combination in digitoxin elimination.
Topics: Canrenone; Cholestyramine Resin; Digitoxin; Drug Interactions; Humans; Spironolactone; Time Factors | 1980 |
[Enterohepatic circulation in liver diseases].
Topics: Animals; Barbiturates; Bile Acids and Salts; Biotransformation; Bisacodyl; Chloramphenicol; Cholestasis; Digitoxin; Enterohepatic Circulation; Humans; Liver Cirrhosis; Liver Diseases; Neomycin; Phenytoin; Rats; Spironolactone | 1980 |
Glucuronidation of digitalis glycosides by rat liver microsomes: stimulation by spironolactone and pregnenolone-16 alpha-carbonitrile.
Topics: Animals; Digitalis Glycosides; Digitoxin; Digoxigenin; Digoxin; Female; Glucuronates; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Spironolactone; Stimulation, Chemical | 1980 |
A STUDY ON THE STRUCTURE-ACTIVITY RELATIONSHIP OF THE CARDIOTONIC STEROIDS.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Anura; Cardiac Glycosides; Desoxycorticosterone; Digitoxin; Dogs; Heart; Pentobarbital; Pharmacology; Research; Spironolactone; Structure-Activity Relationship | 1965 |
Prognostic and therapeutic considerations in pure hypertension vs hypertension and superimposed arteriosclerosis.
Topics: Arteriosclerosis; Blood Pressure; Cold Temperature; Digitalis; Female; Follow-Up Studies; Humans; Hydralazine; Hypertension; Male; Plants, Medicinal; Plants, Toxic; Private Practice; Prognosis; Reserpine; Sex Factors; Spironolactone; Statistics as Topic | 1975 |
Total exchangeable potassium, sodium and chloride in patients with severe valvular heart disease during preparation for cardiac surgery.
Topics: Adult; Aortic Valve Insufficiency; Atrial Fibrillation; Bicarbonates; Blood Proteins; Body Composition; Body Water; Body Weight; Bromine; Cardiac Complexes, Premature; Chlorides; Creatinine; Digitalis; Diuretics; Female; Heart Diseases; Heart Failure; Humans; Male; Middle Aged; Mitral Valve Insufficiency; Phytotherapy; Plants, Medicinal; Plants, Toxic; Potassium; Potassium Chloride; Potassium Isotopes; Sodium; Sodium Isotopes; Spironolactone; Tachycardia | 1973 |
[Clinical picture and treatment of cor pulmonale (author's transl)].
Topics: Anticoagulants; Asthma; Bronchiectasis; Bronchitis; Digitalis; Diuretics; Electrocardiography; Humans; Hypoventilation; Oxygen Inhalation Therapy; Phytotherapy; Plants, Medicinal; Plants, Toxic; Prognosis; Pulmonary Emphysema; Pulmonary Fibrosis; Pulmonary Heart Disease; Sclerosis; Scoliosis; Spironolactone; Triamterene | 1973 |
[Diagnostic procedures in gynecomastia].
Topics: Adolescent; Adult; Diagnosis, Differential; Digitalis; Estradiol Congeners; Gynecomastia; Humans; Hypogonadism; Infant, Newborn; Male; Middle Aged; Neoplasms; Plants, Medicinal; Plants, Toxic; Spironolactone; Testosterone; Testosterone Congeners | 1984 |
[Long-term domiciliary oxygen therapy of cardiac failure and cardiac arrhythmia accompanying respiratory insufficiency (author's transl)].
Topics: Adult; Aged; Arrhythmias, Cardiac; Digitalis; Heart Failure; Humans; Long-Term Care; Male; Middle Aged; Oxygen Inhalation Therapy; Plants, Medicinal; Plants, Toxic; Respiratory Insufficiency; Spironolactone | 1981 |
[Spironolactone in digitalis-requiring cardiac insufficiency following pacemaker implantation].
Topics: Aged; Digitalis; Diuretics; Female; Heart Failure; Humans; Male; Pacemaker, Artificial; Plants, Medicinal; Plants, Toxic; Retrospective Studies; Spironolactone | 1981 |
Therapeutic challenges and management of heart failure during pregnancy (part I).
Topics: Adult; Digitalis; Drug Therapy, Combination; Enalapril; Female; Furosemide; Heart Failure; Humans; Metoprolol; Pregnancy; Pregnancy Complications; Spironolactone; Ultrasonography, Doppler, Color | 2012 |