Page last updated: 2024-08-17

spironolactone and chlorthalidone

spironolactone has been researched along with chlorthalidone in 87 studies

Research

Studies (87)

Timeframe	Studies, this research(%)	All Research%
pre-1990	65 (74.71)	18.7374
1990's	2 (2.30)	18.2507
2000's	5 (5.75)	29.6817
2010's	9 (10.34)	24.3611
2020's	6 (6.90)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
de Wardener, HE; MacGregor, GA; Tasker, PR	1
Atlas, SA; Laragh, JH; Moon, C; Sealey, JE	1
Dalakos, TG; Pinals, RS; Streeten, DH	1
Brunner, HR; Ferguson, RK; Gavras, H; Jaeger, P; Jéquier, E; Turini, GA	1
Lief, PD	1
Esch, I; Gaul, G; Placheta, P	1
Florkiewicz, H; Rumiński, W; Rymar, B; Staśkiewicz, J	1
Ellis, C; Hansson, L; Hunyor, SN; Schork, MA; Zweifler, AJ	1
Benraad, TJ; Drayer, JI; Festen, J; Kloppenborg, PW; van't Laar, A	1
Favilli, R; Gragnoli, G; Nami, R; Puccetti, F; Tanganelli, I	1
Kyncl, J; Oheim, K; Seki, T; Solles, A	1
Boer, P; Dorhout Mees, EJ; Geyskes, GG; Hené, RJ; Koomans, HA; Roos, JC; Van Shaik, BA	1
Espiner, EA; Ikram, H; Nicholls, MG; Stewart, DE	1
Reimold, EW	1
Jahn, H; Kuntzmann, F; Kurtz, T; Reville, P; Stahl, J	1
Branche, G; Chiles, B; Garnier, C; Kilcoyne, MM; Soland, T; Thomson, GE; Williams, M	1
Berg, KJ; Gisholt, K; Wideroe, TE	1
Distler, A	1
Rawlins, MD	1
Ravera, M; Spaziante, B	1
Finnerty, FA	1
Baer, L; Brunner, HR; Bühler, FR; Gavras, H; Gavras, I; Laragh, JH; Vaughan, ED	1
Fagerberg, SE; Göransson, K	1
Froment, A; Froment, R; Zech, P	1
Ikeda, T	1
Leiter, L	1
Selchau, M	1
Brien, TG; Canning, BS; Donohoe, JF; Healy, JJ; McKenna, TJ; Muldowney, FP	1
Schmidt, P	1
Naess, K	1
Domer, FR	1
Portmann, B; Robert, M	1
Tobian, L	1
Fris, T; Lintrup, J; Nissen, NI	1
Grieble, HG; Johnston, LC	1
Foy, JM	1
Bufalari, A; Meloni, G	1
Cocco, F; Dessì Fulgheri, P; Dettori, S; Fiori, C; Glorioso, N; Madeddu, P; Rappelli, A; Sanna, G	1
Kreeft, JH; Larochelle, P; Ogilvie, RI	1
Beermann, B	1
Boer, P; Dorhout Mees, EJ; Koomans, HA; Roos, JC	1
Ames, RP; Peacock, PB	1
Falch, DK; Schreiner, AM	1
Haalboom, JR; Struyvenberg, A	1
Boer, P; Dorhout Mees, EJ; Peuker, KH; Roos, JC	1
Bonet-Domingo, E; Garcia-Alvarez-Coque, MC; Medina-Hernandez, MJ	1
Haris, A; Radó, JP	1
CRANSTON, WI; JUEL-JENSEN, BE	1
PREIS, H; STRATA, A	1
MASSI, GB	1
ISASA, FA	1
COMOLI, G; GHIRINGHELLI, L; MADULI, S	1
MATHISEN, HS	1
HEALY, FA; THAYER, JM	1
PELLET, M; TRAEGER, J	1
DUNLOP, D	1
NESTAL, A; PENA, J; RON, J	1
FULLER, JB; GRIEBLE, HG; JOHNSTON, LC; SCHOENBERGER, JA	1
BAGROS, P	1
BOEHM, P; IRMSCHER, K; ZIMMERMANN, H	1
JOOSSENS, JV; VERBERCKMOES, R; VERWILGEN, R	1
ROMANI, JD	1
CEREDA, UG; FRANZINI, P	1
STOKES, W	1
CONINX, P; LEFEBVRE, P	1
ROWE, WS	1
MIZGALA, HF	1
Ménard, J	1
Handler, J	1
Adams-Huet, B; Arbique, D; Auchus, RJ; Menon, DV; Vongpatanasin, W; Wang, Z	1
Miura, D; Nakamura, K; Ohe, T; Yamanari, H; Yamanari, S	1
Black, HR; Slim, HB; Thompson, PD	1
Floras, JS; Leenen, FH; Ruzicka, M	1
Adams-Huet, B; Arbique, D; Auchus, RJ; Price, A; Raheja, P; Vongpatanasin, W; Wang, Z	1
Kapoor, S	1
Carmona-Puerta, R; Castro-Torres, Y; Fleites-Pérez, A; Jiménez-Garrido, RG	1
Dave, C; Hwang, AY; Smith, SM	1
Calhoun, DA; Judd, EK; Oparil, S; Siddiqui, M	1
Andujar, C; Dutton, M; Edwards, NC; Ferro, CJ; Grant, M; Hayer, MK; Herrey, A; Hiemstra, TF; Ives, N; MacIntyre, I; Mehta, S; Melville, V; Moody, WE; Price, AM; Semple, S; Slinn, G; Steeds, RP; Townend, JN; Webb, DJ; Webster, R; Wheeler, DC; Wilkinson, IB	1
Agarwal, R	1
Chávez-Alonso, G; Chávez-Iñiguez, JS; De la Torre-Quiroga, A; de Quevedo, AA; Font-Yañez, JJ; García-García, G; Gómez-Fregoso, J; Ibarra-Estrada, M; Maggiani-Aguilera, P; Romero-González, G; Romero-Muñóz, A; Sánchez-Villaseca, S	1
Croset, F; Del Hoyo, B; Fabregate, M; Fernández, C; García, M; Gomis, A; Llàcer, P; López, G; Manzano, L; Núñez, J; Ruiz, R	1
Agarwal, R; Georgianos, PI	2
Campos, J; Croset, F; Del Hoyo, B; Fabregate, M; Fernández, C; García, M; Gomis, A; Llàcer, P; López, G; Manzano, L; Núñez, J; Ruiz, R	1

Reviews

13 review(s) available for spironolactone and chlorthalidone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Variability in response to drugs. British medical journal, 1974, Oct-12, Volume: 4, Issue:5936 Topics: Acute Disease; Acylation; Chlorthalidone; Chronic Disease; Depression; Diazoxide; Digoxin; Dose-Response Relationship, Drug; Glomerulonephritis; Humans; Hypertension; Nephrotic Syndrome; Norepinephrine; Nortriptyline; Oxidation-Reduction; Phenylthiourea; Serotonin; Spironolactone; Steroids	1974
[Hypertension--diuretics as antihypertensive agents]. Nihon rinsho. Japanese journal of clinical medicine, 1970, Volume: 28, Issue:4 Topics: Aged; Antihypertensive Agents; Arthritis; Benzothiadiazines; Blood Pressure; Chlorothiazide; Chlorthalidone; Diabetes Mellitus; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Middle Aged; Photosensitivity Disorders; Spironolactone; Triamterene	1970
Combinations of diuretics in the treatment of edema. American heart journal, 1970, Volume: 80, Issue:3 Topics: Acetazolamide; Benzothiadiazines; Chlorthalidone; Diuretics; Edema; Ethacrynic Acid; Furosemide; Glucocorticoids; Heart Failure; Hepatic Encephalopathy; Homeostasis; Humans; Hyperglycemia; Hyperkalemia; Hypokalemia; Liver Cirrhosis; Natriuresis; Nephrotic Syndrome; Organomercury Compounds; Potassium; Potassium Chloride; Spironolactone; Triamterene; Uremia; Uric Acid	1970
[Diuretics. 47]. Pharmazeutische Praxis, 1970, Volume: 9 Topics: Antihypertensive Agents; Bendroflumethiazide; Chlorothiazide; Chlorthalidone; Clopamide; Dichlorphenamide; Diuretics; Edema; Ethacrynic Acid; Furosemide; Glaucoma; Humans; Hydrochlorothiazide; Hydroflumethiazide; Metyrapone; Respiratory Insufficiency; Spironolactone; Sulfonamides; Triamterene	1970
Aspects on pharmacokinetics of some diuretics. Acta pharmacologica et toxicologica, 1984, Volume: 54 Suppl 1 Topics: Amiloride; Bendroflumethiazide; Bumetanide; Chlorthalidone; Diuretics; Furosemide; Humans; Hydrochlorothiazide; Kinetics; Sodium Chloride Symporter Inhibitors; Spironolactone	1984
MANAGEMENT OF RENAL DYSFUNCTION IN CONGESTIVE HEART FAILURE. Biochemical clinics, 1963, Volume: 2 Topics: Acetazolamide; Benzothiadiazines; Chlorthalidone; Diuretics; Heart Failure; Humans; Kidney Diseases; Organomercury Compounds; Physiology; Potassium; Spironolactone; Toxicology	1963
[MECHANISM OF ACTION AND CLINICAL USE OF DIURETICS]. Recenti progressi in medicina, 1963, Volume: 35 Topics: Bendroflumethiazide; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Diuretics; Hydrochlorothiazide; Hydroflumethiazide; Kidney; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Organomercury Compounds; Pharmacology; Physiology; Spironolactone	1963
NEWER DRUGS IN THE TREATMENT OF HYPERTENSION. Canadian Medical Association journal, 1965, Apr-24, Volume: 92 Topics: Antihypertensive Agents; Bretylium Compounds; Chlorothiazide; Chlorthalidone; Diuretics; Drug Therapy; Essential Hypertension; Guanethidine; Hydralazine; Hypertension; Methyldopa; Pargyline; Rauwolfia; Spironolactone; Toxicology	1965
Older blood pressure medications-do they still have a place? The American journal of cardiology, 2011, Jul-15, Volume: 108, Issue:2 Topics: Antihypertensive Agents; Chlorthalidone; Clonidine; Diuretics; Ethacrynic Acid; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Minoxidil; Reserpine; Spironolactone; Vasodilator Agents	2011
Negative effects of chlorthalidone on sympathetic nervous system and insulin resistance in hypertensive patients may be avoided with spironolactone: further studies are still needed. Irish journal of medical science, 2015, Volume: 184, Issue:4 Topics: Blood Pressure; Chlorthalidone; Humans; Hypertension; Insulin Resistance; Spironolactone; Sympathetic Nervous System	2015
Management of hypertension in advanced kidney disease. Current opinion in nephrology and hypertension, 2022, 07-01, Volume: 31, Issue:4 Topics: Blood Pressure; Chlorthalidone; Humans; Hyperkalemia; Hypertension; Mineralocorticoid Receptor Antagonists; Piperidines; Potassium; Pyrazoles; Quinolines; Renal Insufficiency, Chronic; Spironolactone	2022
Hypertension in chronic kidney disease-treatment standard 2023. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023, Nov-30, Volume: 38, Issue:12 Topics: Antihypertensive Agents; Blood Pressure; Chlorthalidone; Humans; Hyperkalemia; Hypertension; Mineralocorticoid Receptor Antagonists; Renal Insufficiency, Chronic; Spironolactone	2023

Trials

13 trial(s) available for spironolactone and chlorthalidone

Article	Year
[Plasma renin activity in essential hypertension: different short- und long-term effects of diuretics (author's transl)]. Wiener klinische Wochenschrift, 1976, Jun-25, Volume: 88, Issue:13 Topics: Adult; Amiloride; Canrenoic Acid; Chlorthalidone; Clinical Trials as Topic; Diuresis; Diuretics; Female; Humans; Hypertension; Long-Term Care; Male; Middle Aged; Renin; Spironolactone; Time Factors	1976
Effect of high dose spironolactone and chlorthalidone in essential hypertension: relation to plasma renin activity and plasma volume. Australian and New Zealand journal of medicine, 1975, Volume: 5, Issue:1 Topics: Adult; Aldosterone; Body Weight; Chlorthalidone; Female; Humans; Hypertension; Male; Middle Aged; Placebos; Plasma Volume; Potassium; Renin; Sodium; Spironolactone	1975
Intrapatient comparison of treatment with chlorthalidone, spironolactone and propranolol in normoreninemic essential hypertension. The American journal of cardiology, 1975, Oct-31, Volume: 36, Issue:5 Topics: Adult; Aldosterone; Blood Pressure; Body Weight; Chlorthalidone; Clinical Trials as Topic; Creatinine; Drug Evaluation; Female; Humans; Hypertension; Male; Middle Aged; Placebos; Propranolol; Renin; Sodium; Spironolactone; Water-Electrolyte Balance	1975
Potassium-sparing agents during diuretic therapy in hypertension. British medical journal, 1971, Jun-26, Volume: 2, Issue:5764 Topics: Adult; Aged; Chlorthalidone; Diuretics; Humans; Hypertension; Middle Aged; Potassium; Potassium Deficiency; Spironolactone; Triamterene	1971
Comparative studies on spironolactone (Aldactone) and chlorthalidone (Hygroton) in the treatment of arterial hypertension. Acta medica Scandinavica, 1966, Volume: 179, Issue:3 Topics: Chlorthalidone; Female; Humans; Hypertension; Male; Natriuresis; Renal Artery Obstruction; Spironolactone	1966
Comparison of chlorthalidone and spironolactone in low--renin essential hypertension. Canadian Medical Association journal, 1983, Jan-01, Volume: 128, Issue:1 Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Renin; Spironolactone	1983
Serum cholesterol during treatment of hypertension with diuretic drugs. Archives of internal medicine, 1984, Volume: 144, Issue:4 Topics: Chlorthalidone; Cholesterol; Diuretics; Humans; Hydrochlorothiazide; Hypertension; Male; Random Allocation; Reserpine; Spironolactone; Triglycerides	1984
Patterns of potassium wasting in response to stepwise combinations of diuretics in nephrotic syndrome. International journal of clinical pharmacology and therapeutics, 1999, Volume: 37, Issue:7 Topics: Aged; Amiloride; Body Weight; Chlorthalidone; Diuresis; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Male; Middle Aged; Nephrotic Syndrome; Potassium; Regression Analysis; Sodium; Spironolactone; Triamterene	1999
Differential effects of chlorthalidone versus spironolactone on muscle sympathetic nerve activity in hypertensive patients. The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:4 Topics: Aldosterone; Analysis of Variance; Blood Pressure; Chlorthalidone; Cross-Over Studies; Diuretics; Heart Rate; Humans; Hypertension; Insulin; Muscle, Skeletal; Potassium; Renin; Spironolactone; Sympathetic Nervous System	2009
Spironolactone and chlorthalidone in uncontrolled elderly hypertensive patients treated with calcium antagonists and angiotensin II receptor-blocker: effects on endothelial function, inflammation, and oxidative stress. Clinical and experimental hypertension (New York, N.Y. : 1993), 2009, Volume: 31, Issue:7 Topics: Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Brachial Artery; C-Reactive Protein; Calcium Channel Blockers; Chlorthalidone; Cross-Over Studies; Diuretics; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Hypertension; Inflammation; Male; Oxidative Stress; Potassium; Sodium Chloride Symporter Inhibitors; Spironolactone; Vasodilation	2009
Spironolactone prevents chlorthalidone-induced sympathetic activation and insulin resistance in hypertensive patients. Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:2 Topics: Action Potentials; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Chlorthalidone; Cross-Over Studies; Diuretics; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Insulin Resistance; Irbesartan; Male; Microelectrodes; Middle Aged; Spironolactone; Sympathetic Nervous System; Tetrazoles; Treatment Outcome	2012
A randomized, multicenter, open-label, blinded end point trial comparing the effects of spironolactone to chlorthalidone on left ventricular mass in patients with early-stage chronic kidney disease: Rationale and design of the SPIRO-CKD trial. American heart journal, 2017, Volume: 191 Topics: Adult; Aged; Chlorthalidone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Heart Ventricles; Humans; Hypertrophy, Left Ventricular; Kidney Failure, Chronic; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Prospective Studies; Pulse Wave Analysis; Single-Blind Method; Sodium Chloride Symporter Inhibitors; Spironolactone; Survival Rate; Time Factors; Treatment Outcome; United States; Vascular Stiffness	2017
The Effect in Renal Function and Vascular Decongestion in Type 1 Cardiorenal Syndrome Treated with Two Strategies of Diuretics, a Pilot Randomized Trial. BMC nephrology, 2022, 01-03, Volume: 23, Issue:1 Topics: Adult; Cardio-Renal Syndrome; Chlorthalidone; Diuretics; Double-Blind Method; Drug Administration Schedule; Female; Furosemide; Humans; Infusions, Intravenous; Male; Middle Aged; Pilot Projects; Prospective Studies; Spironolactone; Treatment Outcome	2022

Other Studies

61 other study(ies) available for spironolactone and chlorthalidone

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Diuretic-induced oedema. Lancet (London, England), 1975, Mar-01, Volume: 1, Issue:7905 Topics: Adult; Aldosterone; Blood Volume; Body Weight; Chlorthalidone; Diuretics; Edema; Female; Furosemide; Humans; Middle Aged; Potassium; Renin; Sodium; Spironolactone; Water-Electrolyte Balance	1975
Plasma renin and "prorenin" in essential hypertension during sodium depletion, beta-blockade, and reduced arterial pressure. Lancet (London, England), 1977, Oct-15, Volume: 2, Issue:8042 Topics: Adult; Blood Pressure; Chlorthalidone; Clonidine; Depression, Chemical; Diet, Sodium-Restricted; Drug Therapy, Combination; Enzyme Precursors; Female; Humans; Hypertension; Male; Middle Aged; Propranolol; Renin; Sodium; Spironolactone	1977
Idiopathic edema as a cause of nonarticular rheumatism. Arthritis and rheumatism, 1979, Volume: 22, Issue:4 Topics: Adult; Body Weight; Capillary Permeability; Chlorthalidone; Dextroamphetamine; Edema; Female; Humans; Hydrochlorothiazide; Middle Aged; Rheumatic Diseases; Sodium; Spironolactone; Water-Electrolyte Balance	1979
[Long-term minoxidil therapy: renin, aldosterone, noradrenaline and the need for beta blockers]. Schweizerische medizinische Wochenschrift, 1978, Nov-04, Volume: 108, Issue:44 Topics: Adult; Aldosterone; Chlorthalidone; Female; Furosemide; Hirsutism; Humans; Hypertension; Male; Middle Aged; Minoxidil; Norepinephrine; Oxprenolol; Propranolol; Pyrimidines; Renin; Spironolactone; Water-Electrolyte Balance	1978
Diuretics. American heart journal, 1978, Volume: 96, Issue:6 Topics: Benzothiadiazines; Chlorthalidone; Diuretics; Ethacrynic Acid; Furosemide; Humans; Kidney; Kidney Tubules, Distal; Loop of Henle; Metolazone; Nephrons; Sodium Chloride Symporter Inhibitors; Spironolactone; Triamterene	1978
[Combined treatment with furosemide, aldactone and hygroton in chronic right-ventricular circulatory failure]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1977, Aug-01, Volume: 30, Issue:15 Topics: Chlorthalidone; Drug Therapy, Combination; Female; Furosemide; Heart Failure; Heart Ventricles; Humans; Male; Spironolactone	1977
[Spironolactone combined with chlorthalidone in the treatment of essential arterial hypertension]. Minerva medica, 1975, Apr-21, Volume: 66, Issue:30 Topics: Aged; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Spironolactone	1975
Antihypertensive action of indapamide. Comparative studies in several experimental models. Arzneimittel-Forschung, 1975, Volume: 25, Issue:10 Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Chlorthalidone; Diuretics; Dogs; Dose-Response Relationship, Drug; Female; Furosemide; Guinea Pigs; Hypertension; Hypertension, Renal; Indapamide; Lethal Dose 50; Male; Mice; Muscle Contraction; Nephrectomy; Rabbits; Rats; Rats, Inbred Strains; Spironolactone; Time Factors; Vena Cava, Inferior	1975
Blood to interstitial fluid volume ratio in chronic hypokalaemic states. European journal of clinical investigation, 1985, Volume: 15, Issue:5 Topics: Bartter Syndrome; Blood Volume; Chlorthalidone; Chronic Disease; Extracellular Space; Female; Humans; Hypertension; Hypokalemia; Male; Spironolactone	1985
Arrhythmogenic potential of diuretic induced hypokalaemia in patients with mild hypertension and ischaemic heart disease. British heart journal, 1985, Volume: 54, Issue:3 Topics: Amiloride; Arrhythmias, Cardiac; Chlorthalidone; Coronary Disease; Cyclopenthiazide; Diuretics; Female; Hormones; Humans; Hypertension; Hypokalemia; Male; Middle Aged; Potassium; Spironolactone	1985
[Angiotensin and saluretics in nephrogenic diabetes insipidus of early infancy]. Zeitschrift fur Kinderheilkunde, 1967, Volume: 101, Issue:1 Topics: Angiotensin II; Body Temperature; Chlorthalidone; Diabetes Insipidus; Electrolytes; Female; Furosemide; Humans; Hydrochlorothiazide; Hypernatremia; Infant, Newborn; Kidney; Kidney Tubules; Sodium; Spironolactone; Sweat	1967
[Inhibition of natriuretic effect of angiotensin by spirolactones and salidiuretics in cirrhosis and arterial hypertension]. Pathologie-biologie, 1969, Volume: 17, Issue:9 Topics: Angiotensin II; Chlorthalidone; Creatinine; Depression, Chemical; Diet, Sodium-Restricted; Glomerular Filtration Rate; Humans; Hypertension; Inulin; Kidney Tubules; Liver Cirrhosis; Natriuresis; Norepinephrine; Potassium; Spironolactone; Water	1969
Characteristics of hypertension in the black population. Circulation, 1974, Volume: 50, Issue:5 Topics: Adult; Angiotensin II; Animals; Black or African American; Cardiomegaly; Cerebrovascular Disorders; Chlorthalidone; Coronary Disease; Drug Therapy, Combination; Female; Guanethidine; Heart Ventricles; Humans; Hydralazine; Hypertension; Male; Methyldopa; Middle Aged; New York City; Rabbits; Radioimmunoassay; Renin; Sodium; Spironolactone	1974
Potassium deficiency in hypertensives treated with diuretics. Analysis of three alternative treatments by an oral test for potassium deficiency. European journal of clinical pharmacology, 1974, Oct-04, Volume: 7, Issue:6 Topics: Adult; Aged; Chlorthalidone; Diuretics; Female; Humans; Hypertension; Male; Potassium; Potassium Deficiency; Spironolactone	1974
[Is essential hypertension still a disease entity? Definition of hyporeninemic hypertension]. Der Internist, 1974, Volume: 15, Issue:3 Topics: Aldosterone; Amiloride; Chlorthalidone; Diagnosis, Differential; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Mineralocorticoids; Prognosis; Renin; Sodium Chloride; Spironolactone; Sympathetic Nervous System	1974
[Hyperuricemia due to diuretics]. Minerva medica, 1973, Jan-20, Volume: 64, Issue:4 Topics: Acetazolamide; Aged; Chlorothiazide; Chlorthalidone; Diuretics; Ethacrynic Acid; Furosemide; Gout; Humans; Hydrochlorothiazide; Middle Aged; Spironolactone; Sulfonamides; Triamterene; Uric Acid	1973
How to treat arterial hypertension. American family physician, 1973, Volume: 7, Issue:4 Topics: Antihypertensive Agents; Chlorothiazide; Chlorthalidone; Cooperative Behavior; Diazoxide; Diuretics; Ethacrynic Acid; Furosemide; Guanethidine; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Kidney; Methyldopa; Physician-Patient Relations; Reserpine; Spironolactone; Sulfonamides; Triamterene	1973
Volume factor in low and normal renin essential hypertension. Treatment with either spironolactone or chlorthalidone. The American journal of cardiology, 1973, Sep-20, Volume: 32, Issue:4 Topics: Adult; Aged; Aldosterone; Blood Pressure; Blood Urea Nitrogen; Chlorthalidone; Creatinine; Female; Humans; Hypertension; Male; Middle Aged; Potassium; Renin; Sodium; Spironolactone	1973
[A comparative study of spironolactone and chlorthalidone in treatment of hypertension]. Lakartidningen, 1974, Jan-16, Volume: 71, Issue:3 Topics: Adult; Blood Glucose; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Potassium; Spironolactone; Uric Acid	1974
[Respective roles of hemodynamic or humoral factors and of hypotensive or salidiuretic drugs in the development of essential hypertension]. Pathologie et biologie, 1965, Volume: 13, Issue:21 Topics: Adult; Chlorthalidone; Diet, Sodium-Restricted; Electrocardiography; Guanethidine; Humans; Hydrochlorothiazide; Hypertension; Hypertension, Malignant; Male; Methyldopa; Middle Aged; Prognosis; Reserpine; Sodium; Spironolactone; Sympathectomy	1965
[Diuresis and diuretics]. Wiener klinische Wochenschrift, 1971, Jun-25, Volume: 83, Issue:25 Topics: Acetazolamide; Acute Disease; Agranulocytosis; Anuria; Biological Transport; Blood Platelet Disorders; Brain Edema; Chlorthalidone; Diuresis; Diuretics; Drug Hypersensitivity; Edema; Ethacrynic Acid; Extracellular Space; Furosemide; Glaucoma; Humans; Hyperaldosteronism; Hypokalemia; Hyponatremia; Kidney Failure, Chronic; Mannitol; Natriuresis; Organomercury Compounds; Prediabetic State; Pulmonary Edema; Skin Diseases; Spironolactone; Thiazines; Triamterene; Water-Electrolyte Balance	1971
[Tendency to edema in withdrawal of diuretics]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1970, Nov-15, Volume: 90, Issue:22 Topics: Chlorthalidone; Diuretics; Edema; Female; Humans; Mineralocorticoid Receptor Antagonists; Spironolactone	1970
Effects of diuretics on cerebrospinal fluid formation and potassium movement. Experimental neurology, 1969, Volume: 24, Issue:1 Topics: Acetazolamide; Animals; Biological Transport; Cats; Cerebrospinal Fluid; Chlorthalidone; Diuretics; Ethacrynic Acid; Female; Furosemide; Injections, Intravenous; Male; Organomercury Compounds; Potassium; Pteridines; Spironolactone; Sulfonamides; Theophylline; Triamterene	1969
[Influence of diuretics on the survival of 180 patients with cirrhosis of the liver and ascites]. Schweizerische medizinische Wochenschrift, 1969, Feb-08, Volume: 99, Issue:6 Topics: Adult; Aged; Alcoholism; Ascites; Chlorothiazide; Chlorthalidone; Diuretics; Ethacrynic Acid; Humans; Hydrochlorothiazide; Liver Cirrhosis; Middle Aged; Spironolactone; Triamterene	1969
Modifying elevated blood pressure: a practical office approach. Minnesota medicine, 1969, Volume: 52, Issue:8 Topics: Chlorothiazide; Chlorthalidone; Diuretics; Humans; Hypertension; Methyldopa; Phytotherapy; Plants, Medicinal; Rauwolfia; Spironolactone; Sympatholytics; Vasodilator Agents; Vasomotor System	1969
Treatment of arterial hypertensive disease with diuretics. V. Spironolactone, an aldosterone antagonist. Archives of internal medicine, 1967, Volume: 119, Issue:3 Topics: Adult; Bendroflumethiazide; Blood Pressure; Body Weight; Chlorthalidone; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Sodium Chloride; Spironolactone; Water-Electrolyte Balance	1967
Acute diuretic induced hyperglycaemia in rats. Life sciences, 1967, May-01, Volume: 6, Issue:9 Topics: Acetazolamide; Adrenalectomy; Animals; Bendroflumethiazide; Chlorthalidone; Ergotamine; Ethacrynic Acid; Furosemide; Hydrochlorothiazide; Hyperglycemia; Male; Organomercury Compounds; Rats; Reserpine; Spironolactone	1967
[The behavior of uricemia during treatment with spironolactone and with other diuretics]. Minerva medica, 1967, Nov-07, Volume: 58, Issue:89 Topics: Acetazolamide; Adolescent; Adult; Aged; Chlorthalidone; Clopamide; Diuretics; Ethacrynic Acid; Female; Furosemide; Gout; Heart Diseases; Humans; Hydrochlorothiazide; Hypertension; Kidney Diseases; Liver Cirrhosis; Male; Middle Aged; Organomercury Compounds; Spironolactone; Sulfonamides; Triamterene; Uric Acid	1967
[Role of renin profile and age in the choice of the therapeutic approach of arterial hypertension (author's transl)]. Giornale italiano di cardiologia, 1981, Volume: 11, Issue:12 Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Atenolol; Chlorthalidone; Diuretics; Drug Therapy, Combination; Humans; Hypertension; Metoprolol; Middle Aged; Prazosin; Renin; Sotalol; Spironolactone	1981
Intrarenal sodium handling during chronic spironolactone treatment. Nephron, 1984, Volume: 38, Issue:4 Topics: Adult; Chlorthalidone; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Male; Natriuresis; Potassium; Sodium; Spironolactone	1984
Changes in urinary electrolytes versus serum electrolytes during treatment of primary hypertension with chlorthalidone alone and in combination with spironolactone. Acta medica Scandinavica, 1981, Volume: 209, Issue:1-2 Topics: Adult; Aldosterone; Chlorthalidone; Drug Therapy, Combination; Electrolytes; Humans; Hypertension; Male; Middle Aged; Renin; Spironolactone	1981
The mechanism underlying chlorthalidone-induced hypokalaemia: effects of sodium restriction, potassium suppletion, spironolactone, and triamterene. The Netherlands journal of medicine, 1982, Volume: 25, Issue:7 Topics: Adult; Chlorthalidone; Diet, Sodium-Restricted; Humans; Hypokalemia; Male; Potassium; Spironolactone; Triamterene	1982
Changes in intrarenal uric acid handling during chronic spironolactone treatment in patients with essential hypertension. Nephron, 1982, Volume: 32, Issue:3 Topics: Body Weight; Chlorthalidone; Female; Humans; Hypertension; Kidney; Male; Spironolactone; Uric Acid	1982
A micellar liquid chromatographic procedure for the determination of amiloride, bendroflumethiazide, chlorthalidone, spironolactone and triamterene in pharmaceuticals. Journal of pharmaceutical and biomedical analysis, 1993, Volume: 11, Issue:8 Topics: Amiloride; Bendroflumethiazide; Chemistry, Pharmaceutical; Chlorthalidone; Chromatography, High Pressure Liquid; Diuretics; Micelles; Spironolactone; Tablets; Triamterene	1993
The effects of spironolactone and chlorthalidone on arterial pressure. Lancet (London, England), 1962, Jun-02, Volume: 1, Issue:7240 Topics: Aldosterone; Arterial Pressure; Blood Pressure; Chlorthalidone; Diuretics; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Spironolactone	1962
[Diuretic and saluretic action of an aldosterone antagonist (spirolactone, SC-9420) associated with an iso-indoline derivative (Hygroton) in refractory cardiac edema]. Bollettino della Societa italiana di cardiologia, 1962, Volume: 7 Topics: Aldosterone; Antihypertensive Agents; Chlorthalidone; Diuretics; Edema, Cardiac; Heart Failure; Indoles; Mineralocorticoid Receptor Antagonists; Spironolactone	1962
[The new diuretics]. Rivista di ostetricia e ginecologia, 1962, Volume: 17 Topics: Acetazolamide; Chlorothiazide; Chlorthalidone; Diuretics; Prednisolone; Prednisone; Spironolactone	1962
[DIAGNOSTIC AND THERAPEUTIC MANAGEMENT OF THE NEPHROTIC SYNDROMES OF INFANCY]. Prensa medica argentina, 1963, Mar-29, Volume: 50 Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antibiotics, Antitubercular; Blood Protein Disorders; Child; Chlorothiazide; Chlorthalidone; Classification; Diagnosis; Humans; Hypocalcemia; Infant; Infant, Newborn; Infant, Newborn, Diseases; Lipid Metabolism; Mechlorethamine; Nephrotic Syndrome; Proteins; Proteinuria; Spironolactone; Thiosemicarbazones; Toxicology	1963
[DIURETIC THERAPY OF DECOMPENSATED HEPATIC CIRRHOSIS]. Minerva medica, 1963, Sep-22, Volume: 54 Topics: Blood Chemical Analysis; Chlorothiazide; Chlorthalidone; Diuresis; Diuretics; Electrolytes; Humans; Hydrochlorothiazide; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Prednisone; Progesterone; Spironolactone; Urine	1963
[DRUG THERAPY OF HIGH BLOOD PRESSURE IN THE PAST, PRESENT AND FUTURE]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1963, Nov-15, Volume: 83 Topics: Antihypertensive Agents; Chlorothiazide; Chlorthalidone; Guanethidine; Humans; Hydralazine; Hypertension; Mecamylamine; Monoamine Oxidase Inhibitors; Pentolinium Tartrate; Pharmacology; Rauwolfia; Spironolactone; Veratrum	1963
[COMPLICATIONS DUE TO DIURETICS IN CURRENT USE]. La Revue du praticien, 1963, Dec-21, Volume: 13 Topics: Acetazolamide; Chlorothiazide; Chlorthalidone; Diuretics; Iatrogenic Disease; Spironolactone; Toxicology	1963
[THE ANTIDIURETIC EFFECT OF DIURETICS AND ITS APPLICATION TO THE TREATMENT OF DIABETES INSIPIDUS DURING INFANCY. A COMPARATIVE STUDY O BETWEEN TRICHLORMETHIAZIDE, CHLORTHALIDONE AND SPIROLACTONE]. Revista clinica espanola, 1963, Nov-15, Volume: 91 Topics: Adolescent; Antidiuretic Agents; Child; Chlorthalidone; Diabetes Insipidus; Diuresis; Diuretics; Humans; Kidney Tubules; Mineralocorticoid Receptor Antagonists; Pharmacology; Spironolactone; Trichlormethiazide; Water-Electrolyte Balance	1963
TREATMENT OF ARTERIAL HYPERTENSIVE DISEASE WITH DIURETICS. III. CHLORTHALIDONE ALONE AND IN COMBINATION WITH SPIRONOLACTONE. The American journal of the medical sciences, 1964, Volume: 247 Topics: Bendroflumethiazide; Cardiomegaly; Chlorides; Chlorthalidone; Coronary Disease; Creatine; Creatinine; Diuretics; Heart Failure; Humans; Hypertension; Placebos; Potassium; Proteinuria; Sodium; Spironolactone; Uremia	1964
[THE TREATMENT OF EDEMA WITH SULFONAMIDE DIURETICS]. Vie medicale (Paris, France : 1920), 1964, Volume: 45 Topics: Acetazolamide; Acidosis; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Dehydration; Diuretics; Edema; Heart Failure; Hepatic Encephalopathy; Humans; Hydrochlorothiazide; Hyperaldosteronism; Hypokalemia; Hyponatremia; Kidney Diseases; Liver Cirrhosis; Spironolactone; Sulfonamides; Toxicology; Triamterene	1964
[ON THE EFFECT OF SALI-DIURETICS IN DIABETES INSIPIDUS]. Deutsches Archiv fur klinische Medizin, 1964, Jan-09, Volume: 209 Topics: Acetazolamide; Adolescent; Chlorthalidone; Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Diuretics; Hydrochlorothiazide; Kidney Function Tests; Pharmacology; Spironolactone; Vasopressins; Water-Electrolyte Balance	1964
TRIAMTERENE COMBINED WITH OTHER DIURETICS IN CONGESTIVE HEART FAILURE. Acta cardiologica, 1964, Volume: 19 Topics: Chlorthalidone; Diuretics; Geriatrics; Heart Failure; Pterins; Spironolactone; Toxicology; Triamterene	1964
[THE INTRODUCTION OF ALDOSTERONE ANTAGONISTS IN THERAPY]. Les Cahiers du College de medecine des hopitaux de Paris, 1964, Volume: 5 Topics: Chlorthalidone; Edema; Humans; Hydrochlorothiazide; Hydroflumethiazide; Mineralocorticoid Receptor Antagonists; Spironolactone	1964
[ON THE SUBJECT OF DIURESIS WITH METOPIRONE (SU-4885)]. Minerva medica, 1964, Jul-28, Volume: 55 Topics: Acetazolamide; Ascites; Chlorthalidone; Diuresis; Diuretics; Humans; Ketones; Liver Cirrhosis; Metyrapone; Mineralocorticoid Receptor Antagonists; Organomercury Compounds; Prednisone; Spironolactone	1964
A NEW EFFECTIVE DIURETIC--LASIX. British medical journal, 1964, Oct-10, Volume: 2, Issue:5414 Topics: Chlorthalidone; Diuretics; Drug Therapy; Furosemide; Heart Failure; Hydrochlorothiazide; Hypokalemia; Injections, Intravenous; Liver Cirrhosis; Potassium; Pulmonary Edema; Sodium; Sodium, Dietary; Spironolactone; Toxicology; Urine	1964
[PRACTICAL PROPOSALS FOR THE USE OF SALURETICS]. Revue medicale de Liege, 1964, Aug-15, Volume: 19 Topics: Benzothiadiazines; Chlorthalidone; Diuretics; Humans; Metabolism; Pharmacology; Potassium; Spironolactone	1964
RECENT ADVANCES AND TRENDS IN DRUG THERAPY. II. DIURETICS. The Medical journal of Australia, 1964, Nov-07, Volume: 2 Topics: Benzothiadiazines; Chlorthalidone; Diuretics; Drug Therapy; Humans; Spironolactone; Toxicology; Triamterene	1964
The 45-year story of the development of an anti-aldosterone more specific than spironolactone. Molecular and cellular endocrinology, 2004, Mar-31, Volume: 217, Issue:1-2 Topics: Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Clinical Trials as Topic; Erectile Dysfunction; Female; Gynecomastia; History, 20th Century; Humans; Male; Mineralocorticoid Receptor Antagonists; Pain; Receptors, Mineralocorticoid; Spironolactone	2004
Maximizing diuretic therapy in resistant hypertension. Journal of clinical hypertension (Greenwich, Conn.), 2007, Volume: 9, Issue:10 Topics: Blood Pressure; Chlorthalidone; Diuretics; Drug Resistance; Drug Therapy, Combination; Humans; Hypertension; Middle Aged; Spironolactone	2007
Central sympathetic inhibition by mineralocorticoid receptor but not angiotensin II type 1 receptor blockade: are prescribed doses too low? Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:2 Topics: Chlorthalidone; Female; Humans; Hypertension; Insulin Resistance; Male; Spironolactone; Sympathetic Nervous System	2012
Emerging pain ameliorating effects of spironolactone: an additional benefit of its use in hypertensive and cardiac patients: recent insights. Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:6 Topics: Chlorthalidone; Female; Humans; Hypertension; Insulin Resistance; Male; Spironolactone; Sympathetic Nervous System	2012
Trends in Antihypertensive Medication Use Among US Patients With Resistant Hypertension, 2008 to 2014. Hypertension (Dallas, Tex. : 1979), 2016, Volume: 68, Issue:6 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure Determination; Calcium Channel Blockers; Chlorthalidone; Cohort Studies; Drug Resistance; Drug Therapy, Combination; Drug Utilization; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Patient Safety; Retrospective Studies; Risk Assessment; Severity of Illness Index; Spironolactone; Treatment Outcome; United States	2016
White-Coat Effect Is Uncommon in Patients With Refractory Hypertension. Hypertension (Dallas, Tex. : 1979), 2017, Volume: 70, Issue:3 Topics: Adult; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlorthalidone; Drug Resistance; Female; Humans; Hypertension; Male; Middle Aged; Prevalence; Prospective Studies; Spironolactone; United States; White Coat Hypertension	2017
Spironolactone and chlorthalidone-old drugs, new uses-but approach with caution. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2022, 02-25, Volume: 37, Issue:3 Topics: Chlorthalidone; Diuretics; Humans; Hypertension; Spironolactone	2022
Comparison of chlorthalidone and spironolactone as additional diuretic therapy in patients with acute heart failure and preserved ejection fraction. European heart journal. Acute cardiovascular care, 2022, Jun-07, Volume: 11, Issue:4 Topics: Aged, 80 and over; Chlorthalidone; Diuretics; Female; Heart Failure; Humans; Male; Sodium; Spironolactone; Stroke Volume; Ventricular Function, Left	2022
Usefulness of urinary potassium to creatinine ratio to predict diuretic response in patients with acute heart failure and preserved ejection fraction. Clinical cardiology, 2023, Volume: 46, Issue:8 Topics: Aged, 80 and over; Chlorthalidone; Creatinine; Diuretics; Female; Heart Failure; Humans; Male; Potassium; Sodium Potassium Chloride Symporter Inhibitors; Spironolactone; Stroke Volume	2023