spiromustine has been researched along with hydantoins in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (94.74) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Adamson, RH; Plowman, J | 1 |
| Bartle, PM; Deen, DF; Hoshino, T; Nomura, K; Williams, ME | 1 |
| Bartle, PM; Deen, DF; Williams, ME | 1 |
| Adamson, RH; Lakings, DB; Owens, ES; Plowman, J | 1 |
| DeVroom, HL; Resio, MJ | 1 |
| Levin, V; Prados, M; Rodriguez, L; Seager, M; Silver, P | 1 |
| Kobayashi, T | 1 |
| Balis, F; Doherty, KM; Ettinger, LJ; Heideman, RL; Jeffries, SL; Kelley, JA; Packer, RJ; Poplack, DG; Reaman, GH; Roth, JS | 1 |
| Brown, TD; Donehower, RC; Ettinger, DS | 1 |
| Baker, LH; Corbett, T; Pazdur, R; Phillips, M; Redman, BG | 1 |
| Da Silva, VF; Feeley, M; Goyal, R; Raaphorst, GP | 1 |
| Driscoll, JS; Haces, A; Heideman, RL; Kelley, JA; Roth, JS | 1 |
| Deen, DF; Jostes, RF; Williams, ME | 1 |
| Shannon, WM; Struck, RF; Suling, WJ; Woolley, CW | 1 |
| Davignon, JP; Davis, RD; Marsoni, S; O'Dwyer, PJ; Plowman, J; Shoemaker, DD | 1 |
| Bjerkvig, R; Deen, DF; Hoshino, T; Sano, Y | 1 |
| Duncan, MS; James, RH; Rose, LM; Struck, RF | 1 |
| Cradock, JC; Flora, KP; Kelley, JA | 1 |
1 review(s) available for spiromustine and hydantoins
| Article | Year |
|---|---|
Spiromustine: a new agent entering clinical trials.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Biotransformation; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Hydantoins; Neoplasms, Experimental; Nitrogen Mustard Compounds | 1983 |
1 trial(s) available for spiromustine and hydantoins
| Article | Year |
|---|---|
A phase I trial of spirohydantoin mustard (NSC 172112) in patients with advanced cancer.
Topics: Adult; Aged; Antineoplastic Agents; Central Nervous System Diseases; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Female; Humans; Hydantoins; Male; Middle Aged; Nausea; Nervous System Neoplasms; Nitrogen Mustard Compounds; Physostigmine; Tomography, X-Ray Computed; Xerostomia | 1986 |
17 other study(ies) available for spiromustine and hydantoins
| Article | Year |
|---|---|
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
The disposition of spirohydantoin mustard (NSC 172112) in rats and dogs.
Topics: Animals; Bile; Dogs; Female; Half-Life; Hydantoins; Male; Nitrogen Mustard Compounds; Rats; Species Specificity; Time Factors; Tissue Distribution | 1979 |
Response of 9L tumor cells in vitro to spirohydantoin mustard.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Hydantoins; Neoplasms, Experimental; Nitrogen Mustard Compounds; Radiation-Sensitizing Agents; Rats; Time Factors | 1979 |
Response of cultured 9L cells to spirohydantoin mustard and X-rays.
Topics: Animals; Brain Neoplasms; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Hydantoins; Mice; Neoplasms, Experimental; Nitrogen Mustard Compounds; Rats; Time Factors | 1979 |
Initial studies on the penetration of spirohydantoin mustard into the cerebrospinal fluid of dogs.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Dogs; Female; Half-Life; Hydantoins; Injections, Intravenous; Nitrogen Mustard Compounds | 1977 |
Spiromustine and intracarotid artery cisplatin in the treatment of glioblastoma multiforme.
Topics: Brain Neoplasms; Carotid Arteries; Cisplatin; Combined Modality Therapy; Drug Evaluation; Glioblastoma; Humans; Hydantoins; Infusions, Intra-Arterial; National Institutes of Health (U.S.); Nitrogen Mustard Compounds; Oncology Nursing; United States | 1986 |
Phase II study of spirohydantoin mustard for the treatment of recurrent malignant gliomas.
Topics: Adult; Brain Neoplasms; Diagnosis-Related Groups; Drug Evaluation; Female; Glioma; Humans; Hydantoins; Male; Middle Aged; Nitrogen Mustard Compounds; Physostigmine | 1987 |
[New developments in chemotherapy for experimental brain metastasis].
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Daunorubicin; Doxorubicin; Floxuridine; Hydantoins; Leukemia, Myeloid; Liver Neoplasms, Experimental; Lomustine; Meningeal Neoplasms; Methotrexate; Neoplasm Transplantation; Nimustine; Nitrogen Mustard Compounds; Nitrosourea Compounds; Procarbazine; Rats | 1985 |
A pediatric phase I and pharmacokinetic study of spirohydantoin mustard.
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Child, Preschool; Drug Evaluation; Female; Humans; Hydantoins; Male; Nervous System; Nitrogen Mustard Compounds; Physostigmine; Protein Binding | 1988 |
Phase I trial of spiromustine (NSC 172112) and evaluation of toxicity and schedule in a murine model.
Topics: Animals; Antineoplastic Agents; Cognition Disorders; Consciousness Disorders; Drug Evaluation; Drug Evaluation, Preclinical; Gastrointestinal Diseases; Humans; Hydantoins; Mice; Mice, Inbred Strains; Neoplasms; Nitrogen Mustard Compounds; Physostigmine; Speech Disorders | 1987 |
Drug cytotoxicity at elevated temperature. In vitro study on the U-87MG glioma cell line.
Topics: Antineoplastic Agents; Aziridines; Benzoquinones; Brain Neoplasms; Carmustine; Cell Line; Cisplatin; Cyclohexenes; Glioma; Hot Temperature; Humans; Hydantoins; In Vitro Techniques; Nitrogen Mustard Compounds | 1987 |
Spiromustine analogues. Relationships between structure, plasma stability, and antitumor activity.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chromatography, Gas; Drug Stability; Hydantoins; Hydrolysis; Leukemia P388; Mass Spectrometry; Mice; Nitrogen Mustard Compounds; Structure-Activity Relationship | 1986 |
The effect of treatment with single and split doses of spirohydantoin mustard on the growth delay of 9L rat brain tumor multicellular spheroids.
Topics: Animals; Brain Neoplasms; Cell Survival; Cells, Cultured; Hydantoins; Nitrogen Mustard Compounds; Rats; Time Factors | 1985 |
Metabolism of spirohydantoin mustard in the mouse. Isolation of an alkylating, mutagenic metabolite.
Topics: Alkylating Agents; Animals; Biotransformation; Female; Hydantoins; In Vitro Techniques; Kinetics; Liver; Male; Mice; Mutagens; Nitrogen Mustard Compounds; Phenobarbital; Salmonella typhimurium | 1983 |
The relative resistance of non-cycling cells in 9L multicellular spheroids to spirohydantoin mustard.
Topics: Animals; Brain Neoplasms; Cell Count; Cell Cycle; Cell Line; Cell Survival; Cells, Cultured; Centrifugation; DNA; Flow Cytometry; Hydantoins; Nitrogen Mustard Compounds; Rats; Time Factors; Tumor Stem Cell Assay | 1983 |
High-performance liquid chromatographic determination of spirohydantoin mustard in a clinically acceptable formulation of fat emulsion.
Topics: Chromatography, High Pressure Liquid; Fat Emulsions, Intravenous; Hydantoins; Nitrogen Mustard Compounds; Quality Control | 1982 |
The hydrolysis of spirohydantoin mustard.
Topics: Animals; Antineoplastic Agents; Chlorides; Chromatography, Gas; Drug Stability; Emulsions; Gas Chromatography-Mass Spectrometry; Hydantoins; Hydrogen-Ion Concentration; Hydrolysis; Mice; Nitrogen Mustard Compounds | 1982 |