spiraprilat has been researched along with enalaprilat anhydrous in 4 studies
| Studies (spiraprilat) | Trials (spiraprilat) | Recent Studies (post-2010) (spiraprilat) | Studies (enalaprilat anhydrous) | Trials (enalaprilat anhydrous) | Recent Studies (post-2010) (enalaprilat anhydrous) |
|---|---|---|---|---|---|
| 20 | 7 | 0 | 846 | 109 | 76 |
| Protein | Taxonomy | spiraprilat (IC50) | enalaprilat anhydrous (IC50) |
|---|---|---|---|
| Angiotensin-converting enzyme | Mus musculus (house mouse) | 0.0115 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.2405 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 0.0054 | |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0012 | |
| Angiotensin-converting enzyme | Rattus norvegicus (Norway rat) | 0.0036 | |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | 0.0024 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bennion, C; Brown, RC; Cook, AR; Manners, CN; Payling, DW; Robinson, DH | 1 |
| Baum, T; Gold, EH; McNamara, P; Neustadt, BR; Smith, EM; Swiss, GF; Sybertz, EJ | 1 |
| Cushman, DW; DeForrest, JM; Duggan, M; Karanewsky, DS; Krapcho, J; Powell, JR; Rovnyak, G; Schwartz, J; Spitzmiller, ER; Turk, C | 1 |
| Antonellis, A; Pula, K; Sybertz, EJ; Watkins, RW | 1 |
4 other study(ies) available for spiraprilat and enalaprilat anhydrous
| Article | Year |
|---|---|
Design, synthesis, and physicochemical properties of a novel, conformationally restricted 2,3-dihydro-1,3,4-thiadiazole-containing angiotensin converting enzyme inhibitor which is preferentially eliminated by the biliary route in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Bile; Drug Design; Indicators and Reagents; Male; Metabolic Clearance Rate; Models, Molecular; Molecular Conformation; Molecular Structure; Rats; Structure-Activity Relationship; Thiadiazoles; X-Ray Diffraction | 1991 |
Angiotensin converting enzyme inhibitors: spirapril and related compounds.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Chemical Phenomena; Chemistry; Dogs; Enalapril; Male; Phenylbutyrates; Rats; Rats, Inbred Strains; Spiro Compounds | 1989 |
Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Enalapril; Enalaprilat; Kinetics; Male; Phosphinic Acids; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1988 |
Effects of spiraprilic acid, an angiotensin converting enzyme inhibitor, on large artery compliance in anesthetized dogs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arteries; Compliance; Dogs; Drug Interactions; Enalapril; Enalaprilat; Female; Hemodynamics; Hydrochlorothiazide; Male; Phenylbutyrates; Prodrugs; Spiro Compounds; Vascular Resistance | 1987 |