Page last updated: 2024-08-23

spiradoline and morphine

spiradoline has been researched along with morphine in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19903 (10.34)18.7374
1990's15 (51.72)18.2507
2000's8 (27.59)29.6817
2010's3 (10.34)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Clark, CR; Halfpenny, PR; Hill, RG; Horwell, DC; Hughes, J; Jarvis, TC; Rees, DC; Schofield, D1
Clarke, GD; Dondio, G; Giardina, G; Petrone, G; Sbacchi, M; Vecchietti, V1
Chen, Y; Liu, J; Mestek, A; Yu, L1
Hayashi, S; Nomura, Y1
Kunihara, M; Nakano, M; Ohyama, M2
Ohno, M; Ueki, S; Yamamoto, T1
Cook, L; Holtzman, SG; Steinfels, GF1
Kamei, J; Kasuya, Y; Tanihara, H2
Hayashi, S; Kunihara, M; Nakano, M; Ohyama, M1
Lewis, RA; Vonvoigtlander, PF1
Archer, S; Glick, SD; Maisonneuve, IM; Raucci, J1
Shibata, S; Tominaga, K; Watanabe, S1
Adams, JU; Adler, MW; Chen, XH; DeRiel, JK; Geller, EB; Liu-Chen, LY1
Dykstra, LA; Pitts, RC1
Glick, SD; Pearl, SM1
Maslov, LN; Naryzhnaya, NV; Tam, SW1
Sutherland, J; Walker, EA; Young, AM; Zhang, L1
Gebhart, GF; Ozaki, N; Sengupta, JN1
Holtzman, SG1
Kanarek, RB; Mandillo, S; Wiatr, C1
Barrett, AC; Cook, CD; Picker, MJ; Terner, JM1
Elliott, JC; Lysle, DT; Wagner, AF1
Adler, MW; Chen, X; Geller, EB1
Holtzman, SG; Michaels, CC1
Climent, L; Horga, A; Horga, JF; Peiró, AM; Zapater, P1
Freet, CS; Grigson, PS; Leuenberger, E; Mosblech, NA; Wheeler, RA1
France, CP; Lu, HY; Minervini, V; Osteicoechea, DC; Padarti, J1

Other Studies

29 other study(ies) available for spiradoline and morphine

ArticleYear
Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:4

    Topics: Acetamides; Analgesics; Animals; Binding, Competitive; Cyclohexylamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Models, Molecular; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship

1988
Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group.
    Journal of medicinal chemistry, 1994, Oct-14, Volume: 37, Issue:21

    Topics: Analgesia; Analgesics; Animals; Computer Simulation; Diuresis; Male; Mice; Molecular Structure; Motor Activity; Pyrrolidines; Rats; Receptors, Opioid, kappa; Structure-Activity Relationship; Tetrahydronaphthalenes; Tetralones

1994
Molecular cloning of a rat kappa opioid receptor reveals sequence similarities to the mu and delta opioid receptors.
    The Biochemical journal, 1993, Nov-01, Volume: 295 ( Pt 3)

    Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzomorphans; Cloning, Molecular; Diprenorphine; DNA, Complementary; Molecular Sequence Data; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sequence Analysis; Sequence Homology, Amino Acid; Transfection

1993
Pre- and post-synaptic effects of spiradoline and U-50488H, selective kappa opioid receptor agonists, in isolated ileum.
    Scandinavian journal of gastroenterology, 1992, Volume: 27, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Morphine; Myenteric Plexus; Naloxone; Pyrrolidines; Rabbits; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, kappa

1992
Central monoaminergic mechanisms in mice and analgesic activity of spiradoline mesylate, a selective kappa-opioid receptor agonist.
    European journal of pharmacology, 1992, Apr-22, Volume: 214, Issue:2-3

    Topics: Analgesics; Animals; Brain; Clomipramine; Desipramine; Fenclonine; Imipramine; Male; Mice; Mice, Inbred ICR; Morphine; Norepinephrine; Phenoxybenzamine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Reserpine; Serotonin

1992
Analgesic and discriminative stimulus properties of U-62,066E, the selective kappa-opioid receptor agonist, in the rat.
    Psychopharmacology, 1992, Volume: 106, Issue:1

    Topics: Analgesics; Animals; Benzomorphans; Cues; Discrimination, Psychological; Dopamine; Dopamine Antagonists; Dynorphins; Male; Morphine; Narcotic Antagonists; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1992
Discriminative stimulus effects of spiradoline, a kappa-opioid agonist.
    Psychopharmacology, 1991, Volume: 105, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Discrimination, Psychological; Ethylketocyclazocine; Generalization, Stimulus; Male; Morphine; Nalorphine; Phencyclidine; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1991
The abilities of specific kappa-opioid agonists, U-50,488H and U-62,066E, to cause antitussive tolerance were lower than that of morphine.
    Japanese journal of pharmacology, 1991, Volume: 56, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antitussive Agents; Binding Sites; Brain Stem; Drug Tolerance; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin

1991
Antitussive effects of two specific kappa-opioid agonists, U-50,488H and U-62,066E, in rats.
    European journal of pharmacology, 1990, Oct-09, Volume: 187, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Cisterna Magna; Cough; Injections; Ketanserin; Male; Methysergide; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Reflex

1990
Analgesic activity of spiradoline mesylate (U-62,066E), a kappa opioid agonist in mice.
    Life sciences, 1989, Volume: 45, Issue:13

    Topics: Analgesia; Analgesics; Animals; Drug Tolerance; Kinetics; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Pyrrolidines

1989
Analgesic and mechanistic evaluation of spiradoline, a potent kappa opioid.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Tolerance; Female; Fenclonine; Male; Mice; Morphine; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa

1988
Kappa opioid inhibition of morphine and cocaine self-administration in rats.
    Brain research, 1995, May-29, Volume: 681, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration

1995
kappa-Opioid receptor agonist protects against ischemic reduction of 2-deoxyglucose uptake in morphine-tolerant rats.
    European journal of pharmacology, 1995, Jun-12, Volume: 279, Issue:2-3

    Topics: Analgesics; Analgesics, Opioid; Animals; Benzomorphans; Brain Ischemia; Deoxyglucose; Drug Tolerance; Hippocampus; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa

1995
An antisense oligodeoxynucleotide to mu-opioid receptors inhibits mu-opioid receptor agonist-induced analgesia in rats.
    European journal of pharmacology, 1995, Feb-24, Volume: 275, Issue:1

    Topics: Analgesia; Analgesics; Analysis of Variance; Animals; Base Sequence; Benzamides; Cerebrospinal Fluid; Endorphins; Injections, Intraventricular; Injections, Subcutaneous; Male; Molecular Sequence Data; Morphine; Oligonucleotides, Antisense; Piperazines; Pyrrolidines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1995
Antinociceptive and response rate-altering effects of kappa opioid agonists, spiradoline, enadoline and U69,593, alone and in combination with opioid antagonists in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3

    Topics: Analgesics; Animals; Azocines; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Saimiri

1994
Effects of spiradoline mesylate, a selective kappa-opioid-receptor agonist, on the central dopamine system with relation to mouse locomotor activity and analgesia.
    Japanese journal of pharmacology, 1993, Volume: 62, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Brain Stem; Cerebral Cortex; Corpus Striatum; Dopamine; Haloperidol; Levodopa; Male; Methamphetamine; Mice; Morphine; Motor Activity; Pyrrolidines

1993
Prolonged antagonism of morphine-induced locomotor stimulation by kappa opioid agonists: enhancement by prior morphine exposure.
    Neuroscience letters, 1996, Jul-26, Volume: 213, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Female; Locomotion; Morphine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Time Factors

1996
Ligands for opioid and sigma-receptors improve cardiac electrical stability in rat models of post-infarction cardiosclerosis and stress.
    Life sciences, 1999, Volume: 65, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; beta-Endorphin; Disease Models, Animal; Dynorphins; Enkephalin, Leucine-2-Alanine; Heart; Immobilization; Ligands; Morphine; Myocardial Infarction; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Stress, Physiological; Ventricular Fibrillation

1999
Discriminative stimulus effects of two doses of fentanyl in rats: pharmacological selectivity and effect of training dose on agonist and antagonist effects of mu opioids.
    Psychopharmacology, 2000, Volume: 148, Issue:2

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Fentanyl; Male; Methadone; Morphine; Nalbuphine; Nalorphine; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu

2000
Differential effects of mu-, delta-, and kappa-opioid receptor agonists on mechanosensitive gastric vagal afferent fibers in the rat.
    Journal of neurophysiology, 2000, Volume: 83, Issue:4

    Topics: Acetamides; Analgesics; Analgesics, Opioid; Animals; Benzamides; Catheterization; Electric Stimulation; Male; Mechanoreceptors; Morphine; Naloxone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Pain; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stomach; Vagus Nerve

2000
Further characterization of the discriminative stimulus effects of spiradoline.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:3

    Topics: Analgesics, Non-Narcotic; Animals; Benzeneacetamides; Discrimination Learning; Drug Interactions; Male; Morphine; Naltrexone; Narcotic Antagonists; Nicotinic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Tetrahydronaphthalenes

2000
Chronic sucrose intake augments antinociception induced by injections of mu but not kappa opioid receptor agonists into the periaqueductal gray matter in male and female rats.
    Brain research, 2001, Nov-30, Volume: 920, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Body Weight; Diet; Drug Synergism; Female; Male; Microinjections; Morphine; Pain Measurement; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Long-Evans; Reaction Time; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Sucrose

2001
Sex differences in (-)-pentazocine antinociception: comparison to morphine and spiradoline in four rat strains using a thermal nociceptive assay.
    Behavioural pharmacology, 2003, Volume: 14, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Female; Male; Morphine; Pain Measurement; Pentazocine; Pyrrolidines; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar; Sex Factors; Species Specificity

2003
Neurokinin 1 receptor signaling mediates sex differences in mu and kappa opioid-induced enhancement of contact hypersensitivity.
    Journal of neuroimmunology, 2006, Volume: 181, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Benzamides; Dermatitis, Contact; Drug Interactions; Female; Male; Morphine; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Quinuclidines; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Signal Transduction; Specific Pathogen-Free Organisms; Substance P

2006
Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test.
    European journal of pharmacology, 2007, Feb-14, Volume: 557, Issue:1

    Topics: Analgesics, Opioid; Animals; Cold Temperature; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Male; Morphine; Nociceptin; Opioid Peptides; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tail; Water

2007
Early postnatal stress alters place conditioning to both mu- and kappa-opioid agonists.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 325, Issue:1

    Topics: Animals; Conditioning, Operant; Female; Male; Morphine; Pyrrolidines; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Physiological

2008
Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation.
    Pharmacological research, 2011, Volume: 64, Issue:1

    Topics: Adrenergic alpha-1 Receptor Antagonists; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Ketanserin; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Pain; Pain Measurement; Pain Threshold; Prazosin; Pyrrolidines; Receptors, Adrenergic, alpha-1; Receptors, Opioid, kappa; Receptors, Serotonin, 5-HT2; Serotonin Antagonists

2011
Fischer rats are more sensitive than Lewis rats to the suppressive effects of morphine and the aversive kappa-opioid agonist spiradoline.
    Behavioral neuroscience, 2013, Volume: 127, Issue:5

    Topics: Analgesics, Opioid; Animals; Association Learning; Cues; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, Opioid, kappa; Saccharin; Species Specificity; Sweetening Agents; Taste

2013
Interactions between kappa and mu opioid receptor agonists: effects of the ratio of drugs in mixtures.
    Psychopharmacology, 2018, Volume: 235, Issue:8

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Male; Morphine; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu

2018