spiradoline has been researched along with morphine in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.34) | 18.7374 |
| 1990's | 15 (51.72) | 18.2507 |
| 2000's | 8 (27.59) | 29.6817 |
| 2010's | 3 (10.34) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clark, CR; Halfpenny, PR; Hill, RG; Horwell, DC; Hughes, J; Jarvis, TC; Rees, DC; Schofield, D | 1 |
| Clarke, GD; Dondio, G; Giardina, G; Petrone, G; Sbacchi, M; Vecchietti, V | 1 |
| Chen, Y; Liu, J; Mestek, A; Yu, L | 1 |
| Hayashi, S; Nomura, Y | 1 |
| Kunihara, M; Nakano, M; Ohyama, M | 2 |
| Ohno, M; Ueki, S; Yamamoto, T | 1 |
| Cook, L; Holtzman, SG; Steinfels, GF | 1 |
| Kamei, J; Kasuya, Y; Tanihara, H | 2 |
| Hayashi, S; Kunihara, M; Nakano, M; Ohyama, M | 1 |
| Lewis, RA; Vonvoigtlander, PF | 1 |
| Archer, S; Glick, SD; Maisonneuve, IM; Raucci, J | 1 |
| Shibata, S; Tominaga, K; Watanabe, S | 1 |
| Adams, JU; Adler, MW; Chen, XH; DeRiel, JK; Geller, EB; Liu-Chen, LY | 1 |
| Dykstra, LA; Pitts, RC | 1 |
| Glick, SD; Pearl, SM | 1 |
| Maslov, LN; Naryzhnaya, NV; Tam, SW | 1 |
| Sutherland, J; Walker, EA; Young, AM; Zhang, L | 1 |
| Gebhart, GF; Ozaki, N; Sengupta, JN | 1 |
| Holtzman, SG | 1 |
| Kanarek, RB; Mandillo, S; Wiatr, C | 1 |
| Barrett, AC; Cook, CD; Picker, MJ; Terner, JM | 1 |
| Elliott, JC; Lysle, DT; Wagner, AF | 1 |
| Adler, MW; Chen, X; Geller, EB | 1 |
| Holtzman, SG; Michaels, CC | 1 |
| Climent, L; Horga, A; Horga, JF; Peiró, AM; Zapater, P | 1 |
| Freet, CS; Grigson, PS; Leuenberger, E; Mosblech, NA; Wheeler, RA | 1 |
| France, CP; Lu, HY; Minervini, V; Osteicoechea, DC; Padarti, J | 1 |
29 other study(ies) available for spiradoline and morphine
| Article | Year |
|---|---|
Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives.
Topics: Acetamides; Analgesics; Animals; Binding, Competitive; Cyclohexylamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Models, Molecular; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1988 |
Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group.
Topics: Analgesia; Analgesics; Animals; Computer Simulation; Diuresis; Male; Mice; Molecular Structure; Motor Activity; Pyrrolidines; Rats; Receptors, Opioid, kappa; Structure-Activity Relationship; Tetrahydronaphthalenes; Tetralones | 1994 |
Molecular cloning of a rat kappa opioid receptor reveals sequence similarities to the mu and delta opioid receptors.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzomorphans; Cloning, Molecular; Diprenorphine; DNA, Complementary; Molecular Sequence Data; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sequence Analysis; Sequence Homology, Amino Acid; Transfection | 1993 |
Pre- and post-synaptic effects of spiradoline and U-50488H, selective kappa opioid receptor agonists, in isolated ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Morphine; Myenteric Plexus; Naloxone; Pyrrolidines; Rabbits; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, kappa | 1992 |
Central monoaminergic mechanisms in mice and analgesic activity of spiradoline mesylate, a selective kappa-opioid receptor agonist.
Topics: Analgesics; Animals; Brain; Clomipramine; Desipramine; Fenclonine; Imipramine; Male; Mice; Mice, Inbred ICR; Morphine; Norepinephrine; Phenoxybenzamine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Reserpine; Serotonin | 1992 |
Analgesic and discriminative stimulus properties of U-62,066E, the selective kappa-opioid receptor agonist, in the rat.
Topics: Analgesics; Animals; Benzomorphans; Cues; Discrimination, Psychological; Dopamine; Dopamine Antagonists; Dynorphins; Male; Morphine; Narcotic Antagonists; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Discriminative stimulus effects of spiradoline, a kappa-opioid agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Discrimination, Psychological; Ethylketocyclazocine; Generalization, Stimulus; Male; Morphine; Nalorphine; Phencyclidine; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
The abilities of specific kappa-opioid agonists, U-50,488H and U-62,066E, to cause antitussive tolerance were lower than that of morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antitussive Agents; Binding Sites; Brain Stem; Drug Tolerance; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin | 1991 |
Antitussive effects of two specific kappa-opioid agonists, U-50,488H and U-62,066E, in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Cisterna Magna; Cough; Injections; Ketanserin; Male; Methysergide; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Reflex | 1990 |
Analgesic activity of spiradoline mesylate (U-62,066E), a kappa opioid agonist in mice.
Topics: Analgesia; Analgesics; Animals; Drug Tolerance; Kinetics; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Pyrrolidines | 1989 |
Analgesic and mechanistic evaluation of spiradoline, a potent kappa opioid.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Tolerance; Female; Fenclonine; Male; Mice; Morphine; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Kappa opioid inhibition of morphine and cocaine self-administration in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration | 1995 |
kappa-Opioid receptor agonist protects against ischemic reduction of 2-deoxyglucose uptake in morphine-tolerant rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzomorphans; Brain Ischemia; Deoxyglucose; Drug Tolerance; Hippocampus; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa | 1995 |
An antisense oligodeoxynucleotide to mu-opioid receptors inhibits mu-opioid receptor agonist-induced analgesia in rats.
Topics: Analgesia; Analgesics; Analysis of Variance; Animals; Base Sequence; Benzamides; Cerebrospinal Fluid; Endorphins; Injections, Intraventricular; Injections, Subcutaneous; Male; Molecular Sequence Data; Morphine; Oligonucleotides, Antisense; Piperazines; Pyrrolidines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Antinociceptive and response rate-altering effects of kappa opioid agonists, spiradoline, enadoline and U69,593, alone and in combination with opioid antagonists in squirrel monkeys.
Topics: Analgesics; Animals; Azocines; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Saimiri | 1994 |
Effects of spiradoline mesylate, a selective kappa-opioid-receptor agonist, on the central dopamine system with relation to mouse locomotor activity and analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Brain Stem; Cerebral Cortex; Corpus Striatum; Dopamine; Haloperidol; Levodopa; Male; Methamphetamine; Mice; Morphine; Motor Activity; Pyrrolidines | 1993 |
Prolonged antagonism of morphine-induced locomotor stimulation by kappa opioid agonists: enhancement by prior morphine exposure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Female; Locomotion; Morphine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Time Factors | 1996 |
Ligands for opioid and sigma-receptors improve cardiac electrical stability in rat models of post-infarction cardiosclerosis and stress.
Topics: Animals; Anti-Arrhythmia Agents; beta-Endorphin; Disease Models, Animal; Dynorphins; Enkephalin, Leucine-2-Alanine; Heart; Immobilization; Ligands; Morphine; Myocardial Infarction; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Stress, Physiological; Ventricular Fibrillation | 1999 |
Discriminative stimulus effects of two doses of fentanyl in rats: pharmacological selectivity and effect of training dose on agonist and antagonist effects of mu opioids.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Fentanyl; Male; Methadone; Morphine; Nalbuphine; Nalorphine; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Differential effects of mu-, delta-, and kappa-opioid receptor agonists on mechanosensitive gastric vagal afferent fibers in the rat.
Topics: Acetamides; Analgesics; Analgesics, Opioid; Animals; Benzamides; Catheterization; Electric Stimulation; Male; Mechanoreceptors; Morphine; Naloxone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Pain; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stomach; Vagus Nerve | 2000 |
Further characterization of the discriminative stimulus effects of spiradoline.
Topics: Analgesics, Non-Narcotic; Animals; Benzeneacetamides; Discrimination Learning; Drug Interactions; Male; Morphine; Naltrexone; Narcotic Antagonists; Nicotinic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Tetrahydronaphthalenes | 2000 |
Chronic sucrose intake augments antinociception induced by injections of mu but not kappa opioid receptor agonists into the periaqueductal gray matter in male and female rats.
Topics: Analgesics, Opioid; Animals; Body Weight; Diet; Drug Synergism; Female; Male; Microinjections; Morphine; Pain Measurement; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Long-Evans; Reaction Time; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Sucrose | 2001 |
Sex differences in (-)-pentazocine antinociception: comparison to morphine and spiradoline in four rat strains using a thermal nociceptive assay.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Female; Male; Morphine; Pain Measurement; Pentazocine; Pyrrolidines; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar; Sex Factors; Species Specificity | 2003 |
Neurokinin 1 receptor signaling mediates sex differences in mu and kappa opioid-induced enhancement of contact hypersensitivity.
Topics: Analgesics, Opioid; Animals; Benzamides; Dermatitis, Contact; Drug Interactions; Female; Male; Morphine; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Quinuclidines; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Signal Transduction; Specific Pathogen-Free Organisms; Substance P | 2006 |
Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test.
Topics: Analgesics, Opioid; Animals; Cold Temperature; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Male; Morphine; Nociceptin; Opioid Peptides; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tail; Water | 2007 |
Early postnatal stress alters place conditioning to both mu- and kappa-opioid agonists.
Topics: Animals; Conditioning, Operant; Female; Male; Morphine; Pyrrolidines; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Physiological | 2008 |
Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation.
Topics: Adrenergic alpha-1 Receptor Antagonists; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Ketanserin; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Pain; Pain Measurement; Pain Threshold; Prazosin; Pyrrolidines; Receptors, Adrenergic, alpha-1; Receptors, Opioid, kappa; Receptors, Serotonin, 5-HT2; Serotonin Antagonists | 2011 |
Fischer rats are more sensitive than Lewis rats to the suppressive effects of morphine and the aversive kappa-opioid agonist spiradoline.
Topics: Analgesics, Opioid; Animals; Association Learning; Cues; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, Opioid, kappa; Saccharin; Species Specificity; Sweetening Agents; Taste | 2013 |
Interactions between kappa and mu opioid receptor agonists: effects of the ratio of drugs in mixtures.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Male; Morphine; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2018 |