spiperone has been researched along with piperidines in 86 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 58 (67.44) | 18.7374 |
| 1990's | 21 (24.42) | 18.2507 |
| 2000's | 6 (6.98) | 29.6817 |
| 2010's | 1 (1.16) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Janssen, PA; Loonen, AJ; Soudijn, W; van Wijngaarden, I | 1 |
| Laduron, PM; Leysen, JE | 1 |
| Baudry, M; Martres, MP; Schwartz, JC | 1 |
| Engel, J; Lundborg, P | 1 |
| Berardi, F; Daniele, E; Govoni, S; Leopoldo, M; Lograno, MD; Perrone, R; Tortorella, V | 1 |
| Gommeren, W; Janssen, PA; Janssen, PM; Leysen, JE; Pauwels, PJ; Wynants, J | 1 |
| Blier, P; de Montigny, C; Debonnel, G; Monnet, FP | 1 |
| Ashby, CR; Edwards, E; Wang, RY | 1 |
| Aghajanian, GK; Sheldon, PW | 1 |
| Cowen, PJ; Gartside, SE | 1 |
| Cohen, ML; Kurz, KD; Schenck, KW | 1 |
| Barone, D; Bendotti, C; Caccia, S; Garattini, S; Mennini, T; Samanin, R | 1 |
| Hatano, K; Hatazawa, J; Ido, T; Ishiwata, K; Itoh, M; Kawashima, K | 1 |
| Steinfels, GF; Tam, SW | 1 |
| Altar, CA; Marshall, JF; O'Neil, S; Walter, RJ | 1 |
| Allen, RC; Dunn, RW; Ellis, DB; Gardner, BA; Glamkowski, EJ; Huger, FP; Jones, MC; Schmid, BL; Stache, U; Strupczewski, JT | 1 |
| Buchman, O; Grigoriadis, DE; Niznik, HB; Pri-Bar, I; Seeman, P | 1 |
| Andree, TH; Koenig, JI; Meltzer, HY; Mikuni, M; Tong, CY | 1 |
| Greiner, HE; Haase, A; Klockow, M; Schmitges, CJ; Seyfried, C | 1 |
| Altar, CA; Neale, RF; Stone, GA; Wasley, AM | 1 |
| Gerhards, HJ; Henning, R; Lattrell, R; Leven, M | 1 |
| Beck, SG; Clarke, WP; Goldfarb, J | 1 |
| Feniuk, W; Humphrey, PP; Perren, MJ; Watts, AD | 1 |
| Forler, C; Fozard, JR; Middlemiss, DN; Tricklebank, MD | 1 |
| De Clerck, F; Janssen, PA; Tollenaere, JP; Xhonneux, B | 1 |
| Biegon, A; Kargman, S; McEwen, BS; Snyder, L | 1 |
| Murrin, LC; Zeng, W | 1 |
| Allen, GS; Huang, S; Peroutka, SJ | 1 |
| Hösli, E; Hösli, L | 1 |
| Conn, PJ; Hartig, PR; Hoffman, BJ; Sanders-Bush, E | 1 |
| Hall, H; Wedel, I | 1 |
| Leff, P; Martin, GR | 1 |
| Gudelsky, GA; Koenig, JI; Meltzer, HY | 1 |
| Kellar, KJ; Stockmeier, CA | 1 |
| Affolter, H; Burkard, WP; Pletscher, A | 1 |
| Grigoriadis, D; Seeman, P | 1 |
| Frost, JJ; Hartig, PR; Scheffel, U; Wagner, HN | 1 |
| Gorzalka, BB; Mendelson, SD | 1 |
| Demenge, P; Feuerstein, C; Guerin, B; Mouchet, P; Silice, C | 1 |
| Nishino, N; Tanaka, C | 1 |
| Balduini, W; Cardellini, M; Cattabeni, F; Cimino, M; Claudi, F; Perlini, V | 1 |
| Laduron, PM; Leysen, JE; Van Dun, J; Wouters, W | 1 |
| Laduron, PM; Luabeya, MK; Maloteaux, JM | 1 |
| Clement-Cormier, Y; Lam, DM; Redburn, DA | 1 |
| Ilien, B; Laduron, PM; Schotte, A | 1 |
| Facoory, BD; Laverty, R; Millar, JA | 1 |
| Iversen, LL; Reynolds, GP; Rossor, MN | 1 |
| Helmeste, DM; Tang, SW | 1 |
| Cheney, DL; Costa, E; Gandolfi, O; Hong, JS | 1 |
| Köhler, C | 2 |
| Finch, CE; Marcusson, JO; Morgan, DG; Winblad, B | 1 |
| Freedman, M; Hamel, L; Luttinger, D; Perrone, M; Ward, SJ | 1 |
| Battaglia, G; Shannon, M; Titeler, M | 1 |
| Biegon, A; Mann, JJ; McBride, PA; McEwen, B | 1 |
| Hayashi, T; Ichida, S; Terao, M | 1 |
| Gudelsky, GA; Meltzer, HY; Mikuni, M; Simonovic, M | 1 |
| Creese, I; Hamblin, MW; Leff, SE | 1 |
| Haubrich, DR; Martin, GE; Williams, M | 1 |
| Janssen, PF; Laduron, PM; Leysen, JE | 1 |
| Totaro, JA; Williams, M | 1 |
| Meltzer, HY; Simonovic, M | 1 |
| Adams, L; Creese, I; Hyttel, J; Leff, S | 1 |
| Cocchi, D; Gil-Ad, I; Locatelli, V; Müller, EE; Parenti, M; Stefanini, E | 1 |
| Assié, MB; Koek, W; Sleight, AJ | 1 |
| Cohen, D; Ehrenkaufer, RL; Evora, PH; Greenberg, JH; Luedtke, RR; Mach, RH; Morton, TE; Nowak, PA; Reivich, M; Shao, L | 1 |
| Carlsson, A; Hansson, L; Lin, CH; Smith, MW; Sonesson, C; Svensson, K; Waters, N; Wikström, H | 1 |
| Dannals, RF; Mathews, WB; Musachio, JL; Ravert, HT; Scheffel, U; Stathis, M | 1 |
| Furukawa, K; Hino, K; Karasawa, T; Kurumiya, S; Noda, Y; Ochi, Y; Oka, M; Une, T | 1 |
| Brelière, JC; Emonds-Alt, X; Gueudet, C; Le Fur, G; Poncelet, M; Soubrié, P | 1 |
| Efange, SM; Khare, AB; Langason, RB; Low, WC | 1 |
| Berardi, F; Giudice, G; Govoni, S; Lucchi, L; Perrone, R; Tortorella, V | 1 |
| Bowery, BJ; Bristow, L; Emms, F; Freedman, S; Kulagowski, J; Patel, S; Razzaque, Z; Seabrook, GR | 1 |
| Jeanjean, AP; Laterre, EC; Maloteaux, JM | 1 |
| Dannals, RF; Gründer, G; Howard, DR; Offord, SJ; Ravert, HT; Salzmann, JK; Szymanski, S; Wilson, PD; Wong, DF; Yokoi, F | 1 |
| Bobirnac, I; Bruinvels, AT; Danzeisen, M; Gazi, L; Geisse, S; Hoyer, D; Schoeffter, P; Schüpbach, E; Sommer, B; Tricklebank, M | 1 |
| Aloyo, VJ; Harvey, JA; Hoffman, ME; Salt, GL | 1 |
| Bakthavachalam, V; Baldessarini, RJ; Kula, NS; Pounds, S; Tarazi, FI; True, CD; Xu, L | 1 |
| Bobirnac, I; Danzeisen, M; Gazi, L; Hoyer, D; Langenegger, D; Schoeffter, P; Schüpbach, E; Sommer, B; Tricklebank, M | 1 |
| Fu, D; Javitch, JA; Lin, H; Strange, PG; Wilson, J | 1 |
| De los Angeles, J; Dukat, M; Glennon, RA; Herndon, J; Ismaiel, AM; Khorana, N; Metwally, K; Teitler, M | 1 |
| Bordeleau, M; Brooks, KM; Corbett, TJ; de Lannoy, I; Hendrix, JA; Kafka, S; Kamboj, RK; Kapples, KJ; Laws-Ricker, L; Lee, DK; Owolabi, J; Palermo, MG; Rizkalla, G; Shimshock, SJ; Shutske, GM; Tomer, JD; Vargas, HM | 1 |
| Chapman, KL; Hutson, PH; Marston, D; Patel, S; Ragan, CI | 1 |
| Hosoi, R; Inoue, O; Ishida, J; Kobayashi, K; Yamaguchi, M | 1 |
| Brann, MR; Davis, RE; Farde, L; Hacksell, U; Halldin, C; Jovanovic, H; Karlsson, P; Mansson, M; Nordstrom, AL; Vanover, KE; Weiner, DM | 1 |
| Feng, Z; Hou, T; Li, Y | 1 |
2 review(s) available for spiperone and piperidines
| Article | Year |
|---|---|
Effects of electroconvulsive shock and serotonin axon lesions on beta-adrenergic and serotonin-2 receptors in rat brain.
Topics: Anesthetics; Animals; Axons; Brain; Cerebral Cortex; Cyclic AMP; Dihydroalprenolol; Electroconvulsive Therapy; Frontal Lobe; Hippocampus; Ketanserin; Norepinephrine; Piperidines; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta; Receptors, Muscarinic; Receptors, Serotonin; Serotonin; Spiperone; Stress, Physiological; Time Factors; Tritium | 1986 |
Ketanserin and spiperone as templates for novel serotonin 5-HT(2A) antagonists.
Topics: Animals; Drug Design; Isoquinolines; Ketanserin; Piperidines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Structure-Activity Relationship | 2002 |
1 trial(s) available for spiperone and piperidines
| Article | Year |
|---|---|
PET analysis of the 5-HT2A receptor inverse agonist ACP-103 in human brain.
Topics: Administration, Oral; Adult; Antipsychotic Agents; Binding, Competitive; Brain; Carbon Radioisotopes; Dose-Response Relationship, Drug; Drug Inverse Agonism; Humans; Male; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; Receptor, Serotonin, 5-HT2A; Spiperone; Urea | 2008 |
83 other study(ies) available for spiperone and piperidines
| Article | Year |
|---|---|
Regional localization of halopemide, a new psychotropic agent, in the rat brain.
Topics: Animals; Antipsychotic Agents; Benzimidazoles; Brain; Butyrophenones; Caudate Nucleus; Domperidone; Male; Piperidines; Psychotropic Drugs; Rats; Spiperone; Subcellular Fractions; Time Factors | 1978 |
Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity.
Topics: Adenylyl Cyclases; Animals; Benzimidazoles; Binding Sites; Cerebral Cortex; Corpus Striatum; Dopamine; Dopamine Antagonists; Haloperidol; Homovanillic Acid; In Vitro Techniques; Piperidines; Rats; Spiperone; Tissue Distribution | 1979 |
3H-Domperidone: a selective ligand for dopamine receptors.
Topics: Animals; Apomorphine; Benzimidazoles; Corpus Striatum; Dopamine Antagonists; In Vitro Techniques; Kinetics; Ligands; Male; Membranes; Mice; Piperidines; Receptors, Dopamine; Spiperone; Time Factors | 1979 |
Increased mesolimbic 3H-spiroperidol binding in 4 week old offspring of nursing rat mothers treated with penfluridol.
Topics: Animal Population Groups; Animals; Animals, Suckling; Butyrophenones; Female; Lactation; Limbic System; Penfluridol; Piperidines; Pregnancy; Rats; Receptors, Dopamine; Spiperone | 1979 |
Oxygen isosteric derivatives of 3-(3-hydroxyphenyl)-N-n-propylpiperidine.
Topics: Animals; Brain; Dopamine Agents; In Vitro Techniques; Ketanserin; Mice; Oxygen; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone | 1992 |
In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone.
Topics: Animals; Antipsychotic Agents; Biogenic Monoamines; Brain; Female; Haloperidol; In Vitro Techniques; Isoxazoles; Male; Neurotransmitter Agents; Piperidines; Pyrimidinones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Risperidone; Spiperone; Tissue Distribution | 1992 |
Modulation by sigma ligands of N-methyl-D-aspartate-induced [3H]noradrenaline release in the rat hippocampus: G-protein dependency.
Topics: Animals; Calcium; Cinnamates; Cyclopropanes; Dose-Response Relationship, Drug; Ethylmaleimide; GTP-Binding Proteins; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Norepinephrine; Pertussis Toxin; Piperidines; Rats; Rats, Inbred Strains; Spiperone; Tritium; Virulence Factors, Bordetella | 1992 |
Action of serotonin in the medial prefrontal cortex: mediation by serotonin3-like receptors.
Topics: Analysis of Variance; Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Frontal Lobe; Indoles; Injections, Intravenous; Iontophoresis; Male; Metergoline; Pindolol; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Spiperone; Tropisetron | 1992 |
Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriform cortex: evidence for the involvement of a 5-HT2-activated interneuron.
Topics: Animals; Cerebral Cortex; Evoked Potentials; In Vitro Techniques; Interneurons; Male; Neural Inhibition; Piperidines; Rats; Rats, Inbred Strains; Ritanserin; Serotonin; Spiperone | 1990 |
Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors.
Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Animals; Dose-Response Relationship, Drug; Ketanserin; Male; Metergoline; Piperidines; Prolactin; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Spiperone | 1990 |
5-HT2-receptor antagonists: alpha 1- vs. 5-HT2-receptor blocking properties in blood vessels.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Ergolines; Ketanserin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phentolamine; Piperidines; Pyrimidinones; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Spiperone | 1988 |
Evidence that central 5-HT2 receptors do not play an important role in the anorectic activity of D-fenfluramine in the rat.
Topics: Animals; Appetite Depressants; Brain Chemistry; Eating; Fenfluramine; Histamine H2 Antagonists; Male; Metergoline; Norfenfluramine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Spiperone | 1989 |
D2-dopamine receptor specific brain uptake of carbon-11-labeled YM-09151-2.
Topics: Animals; Antipsychotic Agents; Benzamides; Brain; Carbon Radioisotopes; Cerebellum; Corpus Striatum; Dogs; Male; Piperidines; Radionuclide Imaging; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Ritanserin; Serotonin Antagonists; Spiperone; Sulpiride | 1989 |
Selective sigma receptor agonist and antagonist affect dopamine neuronal activity.
Topics: Animals; Antipsychotic Agents; Dopamine; In Vitro Techniques; Male; Membranes; Microelectrodes; Narcotic Antagonists; Narcotics; Neurons; Piperidines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spiperone | 1989 |
Brain dopamine and serotonin receptor sites revealed by digital subtraction autoradiography.
Topics: Animals; Autoradiography; Brain; Butaclamol; Computers; Ketanserin; Piperidines; Radiographic Image Enhancement; Radionuclide Imaging; Rats; Receptors, Dopamine; Receptors, Serotonin; Spiperone; Sulpiride | 1985 |
Synthesis and neuroleptic activity of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles.
Topics: Animals; Antipsychotic Agents; Corpus Striatum; In Vitro Techniques; Isoxazoles; Male; Mice; Motor Activity; Oxazoles; Piperidines; Spiperone; Structure-Activity Relationship | 1985 |
Dopamine D2 receptors selectively labeled by a benzamide neuroleptic: [3H]-YM-09151-2.
Topics: Animals; Antipsychotic Agents; Benzamides; Binding, Competitive; Corpus Striatum; Dogs; Guanylyl Imidodiphosphate; Ketanserin; Kinetics; Piperidines; Receptors, Dopamine; Sodium; Spiperone; Substrate Specificity; Tetrahydronaphthalenes | 1985 |
Differential effect of subchronic treatment with various neuroleptic agents on serotonin2 receptors in rat cerebral cortex.
Topics: 5,7-Dihydroxytryptamine; Animals; Antipsychotic Agents; Cerebral Cortex; Chlorpromazine; Clozapine; Female; Haloperidol; Imipramine; Ketanserin; Loxapine; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone; Sulpiride | 1986 |
Studies on the receptor profile of bisoprolol.
Topics: Adrenergic beta-Antagonists; Animals; Binding, Competitive; Bisoprolol; Cattle; Dihydroalprenolol; Domperidone; Humans; In Vitro Techniques; Ketanserin; Male; Piperidines; Prazosin; Propanolamines; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Dopamine; Receptors, Histamine; Receptors, Muscarinic; Spiperone; Tetrahydronaphthalenes; Yohimbine | 1986 |
Typical and atypical antipsychotic occupancy of D2 and S2 receptors: an autoradiographic analysis in rat brain.
Topics: Animals; Antipsychotic Agents; Autoradiography; Binding, Competitive; Brain; Caudate Nucleus; Haloperidol; Ketanserin; Kinetics; Male; Nucleus Accumbens; Olfactory Bulb; Piperidines; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Spiperone | 1986 |
Synthesis and neuroleptic activity of a series of 1-[1-(benzo-1,4-dioxan-2-ylmethyl)-4-piperidinyl]benzim idazolone derivatives.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzimidazoles; Brain; Catalepsy; Cattle; Chemical Phenomena; Chemistry; Male; Mice; Piperidines; Rats; Receptors, Dopamine; Spiperone; Structure-Activity Relationship | 1987 |
Spiperone differentiates multiple 5-hydroxytryptamine responses in rat hippocampal slices in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Butyrophenones; Hippocampus; In Vitro Techniques; Ketanserin; Piperidines; Rats; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes | 1985 |
A comparison of 5-hydroxytryptamine receptors mediating contraction in rabbit aorta and dog saphenous vein: evidence for different receptor types obtained by use of selective agonists and antagonists.
Topics: Animals; Aorta; Dogs; In Vitro Techniques; Ketanserin; Methoxamine; Muscle Contraction; Muscle, Smooth, Vascular; Piperidines; Rabbits; Receptors, Serotonin; Saphenous Vein; Serotonin; Serotonin Antagonists; Spiperone | 1985 |
Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat.
Topics: Animals; Apomorphine; Behavior, Animal; Betaxolol; Haloperidol; Ketanserin; Male; Pindolol; Piperidines; Prazosin; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reserpine; Spiperone | 1985 |
Dependence of the antagonism at human platelet 5-HT2 receptors by ketanserin on the reaction pH.
Topics: Amidines; Blood Platelets; Butyrophenones; Cyproheptadine; Female; Humans; Hydrogen-Ion Concentration; Ketanserin; Kinetics; Male; Piperidines; Platelet Aggregation; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone | 1985 |
Characterization and localization of serotonin receptors in human brain postmortem.
Topics: Adult; Aged; Autoradiography; Binding, Competitive; Diencephalon; Female; Frontal Lobe; Hippocampus; Humans; Ketanserin; Male; Middle Aged; Piperidines; Receptors, Serotonin; Spiperone; Telencephalon | 1986 |
Postnatal ontogeny of dopamine D2 receptors in rat striatum.
Topics: Age Factors; Animals; Animals, Newborn; Corpus Striatum; Ketanserin; Kinetics; Mathematics; Piperidines; Rats; Receptors, Dopamine; Spiperone | 1986 |
Canine basilar artery contractions mediated by 5-hydroxytryptamine1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Basilar Artery; Dogs; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Lysergic Acid Diethylamide; Piperidines; Rats; Receptors, Serotonin; Serotonin; Spiperone; Tetrahydronaphthalenes; Tritium; Vasoconstriction | 1986 |
Binding sites for [3H]dopamine and dopamine-antagonists on cultured astrocytes of rat striatum and spinal cord: an autoradiographic study.
Topics: Animals; Astrocytes; Autoradiography; Binding Sites; Cells, Cultured; Corpus Striatum; Domperidone; Dopamine; Dopamine Antagonists; Flupenthixol; Ketanserin; Piperidines; Rats; Spinal Cord; Spiperone; Stereoisomerism; Tritium | 1986 |
A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover.
Topics: Animals; Cerebral Cortex; Choroid Plexus; In Vitro Techniques; Ketanserin; Mianserin; Phosphatidylinositols; Piperidines; Rats; Receptors, Serotonin; Spiperone | 1986 |
Comparisons between the in vitro binding of two substituted benzamides and two butyrophenones to dopamine-D2 receptors in the rat striatum.
Topics: Animals; Benzamides; Butyrophenones; Corpus Striatum; Domperidone; In Vitro Techniques; Ketanserin; Kinetics; Male; Piperidines; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Salicylamides; Spiperone; Sulpiride | 1986 |
Peripheral 5-HT2-like receptors. Can they be classified with the available antagonists?
Topics: Animals; Aorta, Thoracic; In Vitro Techniques; Jugular Veins; Ketanserin; Male; Methysergide; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Trazodone | 1986 |
Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature Regulation; Ketanserin; Male; Methoxydimethyltryptamines; Pindolol; Piperidines; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes | 1986 |
Verapamil, an antagonist at 5-hydroxytryptamine receptors of human blood platelets.
Topics: Adenosine Diphosphate; Binding, Competitive; Blood Platelets; Cerebral Cortex; Gallopamil; Humans; In Vitro Techniques; Ketanserin; Membranes; Piperidines; Receptors, Serotonin; Spiperone; Verapamil | 1985 |
Complete conversion of brain D2 dopamine receptors from the high- to the low-affinity state for dopamine agonists, using sodium ions and guanine nucleotide.
Topics: Animals; Apomorphine; Brain; Guanine Nucleotides; In Vitro Techniques; Ketanserin; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sodium; Spiperone; Tetrahydronaphthalenes; Tritium | 1985 |
In vivo binding of 125I-LSD to serotonin 5-HT2 receptors in mouse brain.
Topics: Animals; Binding, Competitive; Brain; Cinanserin; Ketanserin; Lysergic Acid Diethylamide; Mianserin; Mice; Piperidines; Receptors, Serotonin; Spiperone; Time Factors; Tissue Distribution | 1985 |
A facilitatory role for serotonin in the sexual behavior of the female rat.
Topics: Animals; Castration; Estradiol; Female; Ketanserin; Methysergide; Piperidines; Progesterone; Quipazine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin; Sexual Behavior, Animal; Spiperone | 1985 |
Changes of the striatal 3H-spiperone binding 3-6 weeks after nigrostriatal denervation and after two years.
Topics: Animals; Butyrophenones; Corpus Striatum; Denervation; Haloperidol; Hydroxydopamines; Ketanserin; Kinetics; Male; Oxidopamine; Piperidines; Rats; Rats, Inbred Strains; Spiperone; Substantia Nigra; Time Factors | 1985 |
Target size analysis of serotonin 5-HT1 and 5-HT2 receptors in bovine brain membranes.
Topics: Animals; Binding, Competitive; Brain Chemistry; Cattle; Caudate Nucleus; Cerebral Cortex; Freeze Drying; Ketanserin; Molecular Weight; Piperidines; Radioligand Assay; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Synaptic Membranes | 1985 |
Interaction of some 2-hydroxybenzylpiperidines with dopamine receptors.
Topics: Adenylyl Cyclase Inhibitors; Animals; Benzyl Compounds; Binding, Competitive; Chemical Phenomena; Chemistry; Corpus Striatum; In Vitro Techniques; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Synaptosomes | 1987 |
Differential photoaffinity labelling of serotonin-S2 receptors and histamine-H1 receptors using 7-azidoketanserin.
Topics: Affinity Labels; Animals; Azides; Binding, Competitive; Butyrophenones; Cerebellum; Cerebral Cortex; Female; Guinea Pigs; Ketanserin; Photolysis; Piperidines; Pyrilamine; Rats; Rats, Inbred Strains; Receptors, Histamine; Receptors, Histamine H1; Receptors, Serotonin; Spiperone | 1985 |
Regional and cortical laminar distributions of serotonin S2, benzodiazepine, muscarinic, and dopamine D2 receptors in human brain.
Topics: Adult; Aged; Brain; Cerebral Cortex; Diazepam; Humans; Ketanserin; Male; Middle Aged; Piperidines; Quinuclidinyl Benzilate; Receptors, Cell Surface; Receptors, Dopamine; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Serotonin; Spiperone; Tissue Distribution | 1984 |
Dopamine receptors in the goldfish retina: 3H-spiroperidol and 3H-domperidone binding; and dopamine-stimulated adenylate cyclase activity.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Benzimidazoles; Butyrophenones; Cyprinidae; Domperidone; Dopamine; Goldfish; In Vitro Techniques; Kinetics; Mice; Piperidines; Receptors, Dopamine; Retina; Spiperone; Stimulation, Chemical | 1980 |
Solubilized serotonin receptors from rat and dog brain. Selective labelling with [3H]ketanserin.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Brain; Butyrophenones; Dogs; Isonipecotic Acids; Ketanserin; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Solubility; Species Specificity; Spiperone; Time Factors | 1982 |
Mechanism of action of ketanserin.
Topics: Animals; Antihypertensive Agents; Humans; Ketanserin; Muscle Contraction; Muscle, Smooth, Vascular; Piperidines; Rats; Receptors, Serotonin; Serotonin Antagonists; Spiperone | 1982 |
Preliminary studies of human cortical 5-HT2 receptors and their involvement in schizophrenia and neuroleptic drug action.
Topics: Antipsychotic Agents; Cerebral Cortex; Humans; Ketanserin; Piperidines; Receptors, Serotonin; Schizophrenia; Spiperone; Substrate Specificity | 1983 |
Unusual acute effects of antidepressants and neuroleptics on S2-serotonergic receptors.
Topics: Amoxapine; Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Fenclonine; Frontal Lobe; Ketanserin; Loxapine; Male; Mianserin; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone | 1983 |
On the neurotoxicity of chlordecone: a role for gamma-aminobutyric acid and serotonin.
Topics: Acetylcholine; Animals; Binding Sites; Brain; Chlordecone; gamma-Aminobutyric Acid; Insecticides; Ketanserin; Male; Mianserin; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Spiperone | 1984 |
Autoradiographic mapping of spirodecanone binding-sites in the hippocampal region of the rat. Evidence for a localization on intrinsic neurons.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Mapping; Butyrophenones; Haloperidol; Hippocampus; Ketanserin; Male; Mianserin; Piperidines; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Dopamine; Serotonin; Spiperone; Tetrahydronaphthalenes | 1984 |
Serotonin-2 binding sites in human frontal cortex and hippocampus. Selective loss of S-2A sites with age.
Topics: Adolescent; Adult; Aged; Aging; Cerebral Cortex; Hippocampus; Humans; Ketanserin; Kinetics; Methysergide; Middle Aged; Organ Specificity; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone | 1984 |
The effects of serotonin antagonists in a behavioral despair procedure in mice.
Topics: Animals; Behavior, Animal; Cyproheptadine; Guinea Pigs; Ketanserin; Male; Methysergide; Mice; Muscle, Smooth; Piperidines; Pizotyline; Rats; Rats, Inbred Strains; Receptors, Histamine; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Trazodone; Tritium | 1984 |
Guanine nucleotides modulate cortical S2 serotonin receptors.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; In Vitro Techniques; Ketanserin; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone | 1984 |
The distribution of serotonin binding sites in the hippocampal region of the rat brain. An autoradiographic study.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Hippocampus; Ketanserin; Male; Methoxydimethyltryptamines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone | 1984 |
Characterization of serotonin binding sites on human platelets.
Topics: Adult; Binding, Competitive; Blood Platelets; Frontal Lobe; Humans; Ketanserin; Male; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone | 1983 |
Selective inhibition by ketanserin and spiroperidol of 5-HT-induced myometrial contraction.
Topics: Animals; Butyrophenones; Estradiol; Female; Ketanserin; Ovary; Piperidines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Spiperone; Uterine Contraction | 1983 |
Interaction of (+)- and (-)-3-PPP with the dopamine receptor in the anterior pituitary gland.
Topics: Animals; Apomorphine; Binding Sites; Cell Membrane; Depression, Chemical; In Vitro Techniques; Male; Methyltyrosines; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereoisomerism | 1984 |
Interactions of agonists with D-2 dopamine receptors: evidence for a single receptor population existing in multiple agonist affinity-states in rat striatal membranes.
Topics: Animals; Binding, Competitive; Butyrophenones; Corpus Striatum; Domperidone; Dopamine Antagonists; Guanine Nucleotides; Ketanserin; Metoclopramide; Piperidines; Radioligand Assay; Rats; Receptors, Dopamine; Sodium; Spiperone; Temperature | 1984 |
A pharmacological comparison of 6,7-dihydroxy-2-dimethylaminotetralin (TL-99) and N-n-propyl-3-(3-hydroxyphenyl)piperidine with (3-PPP) selected dopamine agonists.
Topics: 4-Butyrolactone; Animals; Apomorphine; Cell Membrane; Corpus Striatum; Female; Humans; Hydroxydopamines; Naphthalenes; Oxidopamine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Tetrahydronaphthalenes | 1982 |
In vivo binding of [3H]ketanserin on serotonin S2-receptors in rat brain.
Topics: Animals; Brain; Ketanserin; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Tritium | 1982 |
Interaction of the putative dopamine autoreceptor agonists 3-PPP and TL-99 with [3H]apomorphine binding sites in rat striatal membranes.
Topics: Animals; Apomorphine; Binding Sites; Binding, Competitive; Corpus Striatum; In Vitro Techniques; Kinetics; Membranes; Naphthalenes; Piperidines; Rats; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes | 1982 |
Effect of 3-PPP, a putative dopamine autoreceptor agonist, on rat serum prolactin levels.
Topics: Animals; Apomorphine; Binding, Competitive; Humans; Male; Piperidines; Prolactin; Rats; Receptors, Dopamine; Reserpine; Spiperone; Stereotyped Behavior | 1981 |
Kainate lesion dissociates striatal dopamine receptor radioligand binding sites.
Topics: Animals; Apomorphine; Benzimidazoles; Corpus Striatum; Domperidone; Flupenthixol; In Vitro Techniques; Kainic Acid; Male; Piperidines; Pyrrolidines; Radioligand Assay; Rats; Receptors, Dopamine; Spiperone | 1981 |
Prolactin-releasing effect of a novel anti-dopaminergic drug, domperidone, in the rat.
Topics: Animals; Benzimidazoles; Bromocriptine; Caudate Nucleus; Corpus Striatum; Dopamine Antagonists; Haloperidol; Male; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Receptors, Dopamine; Spiperone | 1980 |
Biphasic displacement of [3H]YM-09151-2 binding in the rat brain by thioridazine, risperidone and clozapine, but not by other antipsychotics.
Topics: Animals; Antipsychotic Agents; Benzamides; Brain; Clozapine; Corpus Striatum; Dopamine D2 Receptor Antagonists; In Vitro Techniques; Isoxazoles; Male; Olfactory Pathways; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Risperidone; Spiperone; Thioridazine | 1993 |
PET imaging studies of dopamine D2 receptors: comparison of [18F]N-methylspiperone and the benzamide analogues [18F]MABN and [18F]MBP in baboon brain.
Topics: Animals; Benzamides; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Female; Fluorine Radioisotopes; Papio; Piperidines; Receptors, Dopamine D2; Spiperone; Tissue Distribution; Tomography, Emission-Computed | 1995 |
Substituted (S)-phenylpiperidines and rigid congeners as preferential dopamine autoreceptor antagonists: synthesis and structure-activity relationships.
Topics: Animals; Benzazepines; Brain; CHO Cells; Cricetinae; Dihydroxyphenylalanine; Dopamine D2 Receptor Antagonists; Habituation, Psychophysiologic; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Molecular Structure; Motor Activity; Optical Rotation; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Serotonin; Reserpine; Serotonin Antagonists; Spiperone; Structure-Activity Relationship; Transfection | 1994 |
(+)-[C-11]-cis-N-benzyl-normetazocine: a selective ligand for sigma receptors in vivo.
Topics: Animals; Binding, Competitive; Brain; Carbon Radioisotopes; Cyclazocine; Haloperidol; Kinetics; Ligands; Male; Mice; Organ Specificity; Pentazocine; Phencyclidine; Piperidines; Receptors, sigma; Spiperone; Stereoisomerism; Tissue Distribution; Tomography, Emission-Computed | 1994 |
Pharmacological profile of AD-5423, a novel antipsychotic with both potent dopamine-D2 and serotonin-S2 antagonist properties.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Biogenic Monoamines; Clozapine; Dogs; Dopamine D2 Receptor Antagonists; Guinea Pigs; Haloperidol; Macaca fascicularis; Male; Mice; Mice, Inbred Strains; Neurotransmitter Uptake Inhibitors; Piperazines; Piperidines; Prosencephalon; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Tritium | 1993 |
Turning behavior induced in mice by a neurokinin A receptor agonist: stereoselective blockade by SR 48968, a non-peptide receptor antagonist.
Topics: Animals; Behavior, Animal; Benzamides; Corpus Striatum; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Female; Injections; Injections, Intraperitoneal; Mice; Mice, Inbred Strains; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spiperone; Stereoisomerism; Stereotyped Behavior | 1993 |
The vesamicol receptor ligand (+)-meta-[125I]iodobenzyltrozamicol [(+)-[125I]-MIBT] reveals blunting of the striatal cholinergic response to dopamine D2 receptor blockade in the 6-hydroxydopamine (6-OHDA)-lesioned rat: possible implications for Parkinson'
Topics: Animals; Brain Diseases; Cholinergic Fibers; Corpus Striatum; Disease Models, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Iodine Radioisotopes; Iodobenzenes; Ligands; Male; Oxidopamine; Parkinson Disease; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cholinergic; Spiperone | 1996 |
Novel potent sigma 1 ligands: N-[omega-(tetralin-1-yl)alkyl]piperidine derivatives.
Topics: Animals; Hippocampus; Ketanserin; Phencyclidine; Piperidines; Rats; Receptors, Phencyclidine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, sigma; Spiperone; Structure-Activity Relationship; Tetrahydronaphthalenes | 1996 |
Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626.
Topics: Animals; Benzopyrans; Cloning, Molecular; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Electrophysiology; Indoles; Male; Mesencephalon; Neurons; Oxazines; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Spiperone | 1996 |
Neuroleptic binding to sigma receptors: possible involvement in neuroleptic-induced acute dystonia.
Topics: Animals; Antipsychotic Agents; Dopamine Agonists; Dyskinesia, Drug-Induced; Male; Piperidines; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, sigma; Spiperone | 1997 |
Time course of 5-HT2A receptor occupancy in the human brain after a single oral dose of the putative antipsychotic drug MDL 100,907 measured by positron emission tomography.
Topics: Adult; Antipsychotic Agents; Brain; Carbon Radioisotopes; Female; Fluorobenzenes; Humans; Male; Piperidines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Time Factors; Tomography, Emission-Computed | 1997 |
The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor.
Topics: Aminopyridines; Antipsychotic Agents; Cell Line; Clozapine; Colforsin; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Humans; Kidney; Piperidines; Pyridines; Pyrroles; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone | 1998 |
Agonist and antagonist binding to rabbit cortical 5-HT2A receptors: opposite effects of magnesium.
Topics: Amphetamines; Animals; Cerebral Cortex; Fluorobenzenes; Guanylyl Imidodiphosphate; Ketanserin; Magnesium; Methysergide; Piperidines; Prazosin; Rabbits; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone | 1998 |
Neuropharmacological assessment of potential dopamine D4 receptor-selective radioligands.
Topics: Aminopyridines; Animals; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Dopamine Agents; Dopamine Antagonists; Haloperidol; Humans; In Vitro Techniques; Ligands; Male; Piperidines; Prosencephalon; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4; Spiperone; Tritium | 1999 |
Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L-745,870 and U-101958 at human recombinant D4.4 receptors expressed in CHO cells.
Topics: Aminopyridines; Animals; Butyrates; CHO Cells; Cricetinae; Cyclic AMP; Dopamine Agents; Humans; Ligands; Piperidines; Pyridines; Pyrroles; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Spiperone | 1999 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
Synthesis and structure-activity relationship of the isoindolinyl benzisoxazolpiperidines as potent, selective, and orally active human dopamine D4 receptor antagonists.
Topics: Administration, Oral; Animals; Apomorphine; Benzyl Compounds; Dizocilpine Maleate; Dopamine D2 Receptor Antagonists; Indoles; Infusions, Parenteral; Isoxazoles; Piperidines; Prazosin; Rats; Receptors, Dopamine D4; Serine; Spiperone; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2002 |
Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina.
Topics: Animals; Binding Sites; Cyclic AMP; Darkness; Dopamine Agonists; Dopamine Antagonists; In Vitro Techniques; Indoles; Male; Piperidines; Pyridines; Pyrroles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4; Retina; Spiperone | 2003 |
Effect of sabcomeline on muscarinic and dopamine receptor binding in intact mouse brain.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Diagnostic Techniques, Radioisotope; Dose-Response Relationship, Drug; Imines; Male; Metabolic Clearance Rate; Mice; Mice, Inbred Strains; Organ Specificity; Piperidines; Protein Binding; Quinuclidines; Quinuclidinyl Benzilate; Raclopride; Radionuclide Imaging; Radiopharmaceuticals; Receptors, Dopamine; Spiperone; Tissue Distribution; Tritium | 2003 |
Structure-based drug design for dopamine D3 receptor.
Topics: Animals; Combinatorial Chemistry Techniques; Drug Design; Haloperidol; Humans; Indoles; Mice; Models, Molecular; Molecular Structure; Piperazines; Piperidines; Pyrazoles; Pyridines; Receptors, Dopamine D3; Spiperone; Structure-Activity Relationship; Sulpiride; Thiophenes | 2012 |