Page last updated: 2024-08-16

spiperone and phentolamine

spiperone has been researched along with phentolamine in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199021 (65.63)18.7374
1990's8 (25.00)18.2507
2000's1 (3.13)29.6817
2010's2 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Andrews, PR; Craik, DJ; Martin, JL1
Bondinell, WE; Hieble, JP; Ruffolo, RR1
Baldessarini, RJ; Booth, RG; Charifson, PS; Kula, NS; McPhail, AT; Myers, AM; Owens, CE; Wyrick, SD1
Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM1
Berardi, F; Colabufo, NA; Leopoldo, M; Perrone, R; Tortorella, V1
Pedretti, A; Testa, B; Villa, L; Vistoli, G1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Clark, D; Willner, P1
Carmichael, R; Di Paolo, T; Labrie, F; Raynaud, JP1
Giachetti, A; Hefco, E; Jameson, HE; Krulich, L; Marchlewska-Koj, A1
Kuruma, I; Naitoh, F; Nakajima, T1
Seeman, P; Whitaker, PM1
Erickson, CK; Matchett, JA1
Kordecka, A; Maj, J; Mogilnicka, E1
Carlson, KR; Eibergen, RD2
Berthoud, HR; Mogenson, GJ1
Antelman, SM; Szechtman, H1
Motevalian, M; Parsons, AA; Whalley, ET1
Cohen, ML; Kurz, KD; Schenck, KW1
Frenken, M1
Alexander, BS; Broadhurst, AM; Wood, MD1
Briley, M; Langer, SZ; Lehmann, J1
Charlton, KG; Clarke, DE; Hamed, AT; Johnson, TD1
Agid, Y; Bokobza, B; Javoy-Agid, F; Montfort, JC; Ruberg, M1
Baraldi, M; Benelli, A; Sandrini, M1
Martin, LL; Sanders-Bush, E1
Guarneri, L; Leonardi, A; Poggesi, E; Simonazzi, I; Taddei, C; Testa, R1
Docherty, JR; Kearns, S; O'Rourke, M1
Aghajanian, GK; Marek, GJ1

Reviews

2 review(s) available for spiperone and phentolamine

ArticleYear
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
    Journal of medicinal chemistry, 1995, Sep-01, Volume: 38, Issue:18

    Topics: Animals; Humans; Molecular Biology; Molecular Structure; Radioligand Assay; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta

1995
The role of receptor binding in drug discovery.
    Journal of natural products, 1993, Volume: 56, Issue:4

    Topics: Animals; Drug Design; Humans; Receptors, Drug

1993

Other Studies

30 other study(ies) available for spiperone and phentolamine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
Conformational analysis, pharmacophore identification, and comparative molecular field analysis of ligands for the neuromodulatory sigma 3 receptor.
    Journal of medicinal chemistry, 1994, Nov-25, Volume: 37, Issue:24

    Topics: Animals; Ligands; Models, Molecular; Molecular Conformation; Receptors, sigma; Rodentia; Structure-Activity Relationship; Tetrahydronaphthalenes

1994
1-aryl-4-[(5-methoxy-1,2,3, 4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5.
    Journal of medicinal chemistry, 1999, Feb-11, Volume: 42, Issue:3

    Topics: Animals; CHO Cells; Cricetinae; Gas Chromatography-Mass Spectrometry; Humans; Magnetic Resonance Spectroscopy; Piperazines; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes

1999
Range and sensitivity as descriptors of molecular property spaces in dynamic QSAR analyses.
    Journal of medicinal chemistry, 2005, Jul-28, Volume: 48, Issue:15

    Topics: Chemical Phenomena; Chemistry, Physical; Ligands; Models, Molecular; Molecular Conformation; Monte Carlo Method; Quantitative Structure-Activity Relationship; Receptors, Adrenergic, alpha-1; Solvents

2005
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
A reappraisal of the interaction between tricyclic antidepressants and reserpine-like drugs.
    Psychopharmacology, 1978, Jun-15, Volume: 58, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Conditioning, Operant; Desipramine; Drug Interactions; Male; Motor Activity; Phenoxybenzamine; Phentolamine; Pimozide; Rats; Reserpine; Spiperone; Tetrabenazine; Time Factors

1978
Effects of estrogens on the characteristics of [3H]spiroperidol and [3H]RU24213 binding in rat anterior pituitary gland and brain.
    Molecular and cellular endocrinology, 1979, Volume: 16, Issue:2

    Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butyrophenones; Castration; Clonidine; Dihydroergotoxine; Estradiol; Female; Phenethylamines; Phentolamine; Pituitary Gland, Anterior; Rats; Receptors, Dopamine; Spiperone

1979
On the role of the central noradrenergic and dopaminergic systems in the regulation of TSH secretion in the rat.
    Endocrinology, 1977, Volume: 100, Issue:2

    Topics: Animals; Apomorphine; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Clonidine; Ditiocarb; Dopamine; Kinetics; Male; Methyltyrosines; Norepinephrine; Phenoxybenzamine; Phentolamine; Pituitary Gland; Propranolol; Rats; Spiperone; Stress, Physiological; Thyrotropin; Thyrotropin-Releasing Hormone

1977
Dopamine-sensitive adenylate cyclase in the rat kidney particulate preparation.
    European journal of pharmacology, 1977, Jan-21, Volume: 41, Issue:2

    Topics: Adenylyl Cyclases; Animals; Catecholamines; Cyclic AMP; Dopamine; Dopamine Antagonists; Drug Interactions; In Vitro Techniques; Kidney; Male; Phentolamine; Propranolol; Rats; Spiperone; Stimulation, Chemical; Theophylline

1977
Selective labeling of apomorphine receptors by 3H-LSD.
    European journal of pharmacology, 1979, Jun-15, Volume: 56, Issue:3

    Topics: Animals; Apomorphine; Cattle; Caudate Nucleus; Lysergic Acid Diethylamide; Phentolamine; Receptors, Dopamine; Receptors, Opioid; Serotonin; Spiperone; Tritium

1979
Alteration of ethanol-induced changes in locomotor activity by adrenergic blockers in mice.
    Psychopharmacology, 1977, Apr-29, Volume: 52, Issue:2

    Topics: Animals; Drug Interactions; Ethanol; Female; Mice; Mice, Inbred ICR; Motor Activity; Phentolamine; Propranolol; Spiperone; Sympatholytics; Time Factors

1977
Chronic treatment with antidepressant drugs: potentiation of apomorphine-induced aggressive behaviour in rats.
    Neuroscience letters, 1979, Volume: 13, Issue:3

    Topics: Aggression; Animals; Antidepressive Agents; Apomorphine; Behavior; Drug Interactions; Humans; Male; Metergoline; Phenoxybenzamine; Phentolamine; Rats; Spiperone; Stereotyped Behavior; Time Factors

1979
Dyskinesias in monkeys: interaction of methamphetamine with prior methadone treatment.
    Pharmacology, biochemistry, and behavior, 1976, Volume: 5, Issue:2

    Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methamphetamine; Naloxone; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Stereotyped Behavior

1976
Susceptibility to amphetamine-elicited dyskinesias following chronic methadone treatment in monkeys.
    Annals of the New York Academy of Sciences, 1976, Volume: 281

    Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Drug Interactions; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Macaca mulatta; Male; Methadone; Methamphetamine; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Time Factors

1976
Ingestive behavior after intracerebral and intracerebroventricular infusions of glucose and 2-deoxy-D-glucose.
    The American journal of physiology, 1977, Volume: 233, Issue:3

    Topics: Animals; Brain; Cerebral Ventricles; Deoxy Sugars; Deoxyglucose; Drinking Behavior; Feeding Behavior; Glucose; Hypothalamus; Injections; Injections, Intraventricular; Male; Methysergide; Phentolamine; Rats; Receptors, Drug; Spiperone

1977
Tail pinch induces eating in sated rats which appears to depend on nigrostriatal dopamine.
    Science (New York, N.Y.), 1975, Aug-29, Volume: 189, Issue:4204

    Topics: Animals; Behavior, Animal; Consummatory Behavior; Corpus Striatum; Depression, Chemical; Dopamine; Feeding Behavior; Haloperidol; Hydroxydopamines; Male; Norepinephrine; Phentolamine; Pimozide; Rats; Receptors, Adrenergic; Receptors, Drug; Sotalol; Spiperone; Stress, Physiological; Substantia Nigra; Time Factors

1975
Contractile effects of 8-hydroxy-2-(di-n-propylamino)tetralin and flesinoxan in human isolated basilar artery.
    European journal of pharmacology, 1991, Sep-04, Volume: 202, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Antihypertensive Agents; Basilar Artery; Humans; In Vitro Techniques; Indoles; Methiothepin; Muscle Contraction; Muscle, Smooth, Vascular; Phentolamine; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Sulfonamides; Sumatriptan; Tetrahydronaphthalenes; Vasoconstrictor Agents

1991
5-HT2-receptor antagonists: alpha 1- vs. 5-HT2-receptor blocking properties in blood vessels.
    Journal of cardiovascular pharmacology, 1988, Volume: 11 Suppl 1

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Ergolines; Ketanserin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phentolamine; Piperidines; Pyrimidinones; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Spiperone

1988
Evidence for two populations of 5-hydroxytryptamine receptors in dog basilar artery.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:1

    Topics: Animals; Basilar Artery; Cocaine; Dogs; In Vitro Techniques; Indomethacin; Ketanserin; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phentolamine; Potassium; Prazosin; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Spiperone; Vasoconstriction

1989
Heterogeneous 3H-rauwolscine binding sites in rat cortex: two alpha 2-adrenoceptor subtypes or an additional non-adrenergic interaction?
    Life sciences, 1988, Volume: 43, Issue:1

    Topics: Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Creatinine; Dioxanes; Drug Combinations; Hippocampus; Ketanserin; Male; Methysergide; Phentolamine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin; Spiperone; Spiro Compounds; Yohimbine

1988
Characterization of dopamine autoreceptor and [3H]spiperone binding sites in vitro with classical and novel dopamine receptor agonists.
    European journal of pharmacology, 1983, Mar-18, Volume: 88, Issue:1

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Agonists; Animals; Apomorphine; Benzazepines; Binding Sites; Bromocriptine; Butyrophenones; Cats; Caudate Nucleus; Dopamine; Electric Stimulation; Female; In Vitro Techniques; Male; Phentolamine; Receptors, Dopamine; Spiperone; Sulpiride; Tritium

1983
Cardiovascular actions of kynuramine and 5-hydroxykynuramine in pithed rats.
    Journal of neural transmission, 1983, Volume: 57, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Azepines; Blood Pressure; Brain; Cerebral Cortex; Decerebrate State; Heart Rate; Kynuramine; Male; Phentolamine; Phenylephrine; Propiophenones; Propranolol; Rats; Receptors, Adrenergic, alpha; Spiperone; Yohimbine

1983
[3H]spiperone binding in the nigrostriatal system in human brain.
    European journal of pharmacology, 1984, Mar-23, Volume: 99, Issue:2-3

    Topics: Aged; Apomorphine; Binding, Competitive; Butaclamol; Butyrophenones; Caudate Nucleus; Cinanserin; Corpus Striatum; Domperidone; Female; Haloperidol; Humans; In Vitro Techniques; Kinetics; Male; Nerve Endings; Phentolamine; Postmortem Changes; Putamen; Spiperone; Substantia Nigra; Sulpiride; Time Factors

1984
Dopamine receptors in the guinea-pig heart. A binding study.
    Life sciences, 1984, Oct-29, Volume: 35, Issue:18

    Topics: Animals; Cell-Free System; Dopamine; Guinea Pigs; Hydrogen-Ion Concentration; Kinetics; Myocardium; Phentolamine; Receptors, Dopamine; Sarcolemma; Spiperone; Temperature

1984
The serotonin autoreceptor: antagonism by quipazine.
    Neuropharmacology, 1982, Volume: 21, Issue:5

    Topics: Animals; Calcium; Fluoxetine; Hypothalamus; In Vitro Techniques; Male; Methiothepin; Phentolamine; Potassium; Quinolines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone

1982
Mediation of noradrenaline-induced contractions of rat aorta by the alpha 1B-adrenoceptor subtype.
    British journal of pharmacology, 1995, Volume: 114, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Clonidine; Computer Simulation; Hippocampus; In Vitro Techniques; Liver; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phentolamine; Piperazines; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Regression Analysis; Spiperone; Stereoisomerism; Sulfonamides

1995
Investigation of the actions of chloroethylclonidine in rat aorta.
    British journal of pharmacology, 1995, Volume: 115, Issue:8

    Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Aorta; Clonidine; Cystamine; Dioxanes; Dose-Response Relationship, Drug; Drug Synergism; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxathiins; Phenoxybenzamine; Phentolamine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spiperone; Xylazine; Yohimbine

1995
Alpha 1B-adrenoceptor-mediated excitation of piriform cortical interneurons.
    European journal of pharmacology, 1996, Jun-03, Volume: 305, Issue:1-3

    Topics: Action Potentials; Adrenergic alpha-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Dioxanes; In Vitro Techniques; Interneurons; Male; Norepinephrine; Oxathiins; Phentolamine; Piperazines; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Risperidone; Spiperone

1996