spiperone has been researched along with haloperidol in 424 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 275 (64.86) | 18.7374 |
| 1990's | 106 (25.00) | 18.2507 |
| 2000's | 29 (6.84) | 29.6817 |
| 2010's | 14 (3.30) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| George, SR; Guan, HC; Laurier, LG; Ng, G; Niznik, HB; O'Dowd, BF; Seeman, P; Sunahara, RK; Torchia, J; Van Tol, HH | 1 |
| Bouthenet, ML; Giros, B; Martres, MP; Schwartz, JC; Sokoloff, P | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Butler, DE; Coughenour, LL; DeWald, HA; Downs, DA; Lewis, EP; Lobbestael, SJ; Pattison, IC; Poschel, BP; Tecle, H; Wise, LD | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Demattos, S; MacKenzie, RG; O'Malley, KL; Pugsley, TA; Shih, YH; Tang, L; Todd, RD; VanLeeuwen, D | 1 |
| Choudhary, MS; Craigo, SC; Meltzer, HY; Monsma, FJ; Roth, BL; Shen, Y; Sibley, DR; Uluer, A | 1 |
| Baldessarini, RJ; Booth, RG; Charifson, PS; Kula, NS; McPhail, AT; Myers, AM; Owens, CE; Wyrick, SD | 1 |
| Amlaiky, N; Hen, R; Plassat, JL | 1 |
| Arrang, JM; Diaz, J; Leurs, R; Ruat, M; Schwartz, JC; Tardivel-Lacombe, J; Traiffort, E | 1 |
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Dokhan, R; el Ahmad, Y; Laurent, E; Maillet, P; Ollivier, R; Talab, A; Teste, JF; Tran, G | 1 |
| Chang, DJ; Eglen, RM; Jasper, JR; Kosaka, A; To, ZP | 1 |
| Baez, M; Kursar, JD; Lucaites, VL; Nelson, DL; Sasso, DA; Wainscott, DB | 1 |
| Egan, CT; Herrick-Davis, K; Teitler, M | 1 |
| Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Booth, RG; Brown, RL; Bucholtz, EC; Tropsha, A; Wyrick, SD | 1 |
| Glennon, RA | 1 |
| Fang, X; Hu, Z; Levant, B; Min, J; Varady, J; Wang, S; Wu, X | 1 |
| Brasili, L; Costantino, L; Franchini, S; Gandolfi, F; Leonardi, A; Poggesi, E; Prezzavento, O; Ronsisvalle, G; Sorbi, C; Vittorio, F | 1 |
| Boeckler, F; Gmeiner, P; Lanig, H | 1 |
| Berardi, F; Colabufo, NA; Contino, M; Lacivita, E; Leopoldo, M; Perrone, R | 1 |
| Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L | 1 |
| Kitamura, Y; Kozaka, T; Miwa, D; Ogawa, K; Shiba, K; Uno, I | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, K; Gao, B; Guo, L; Jiang, H; Li, Z; Liu, H; Qian, W; Sun, H; Yang, H; Zhen, X; Zhou, S; Zhou, Y; Zhu, L | 1 |
| Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L | 1 |
| Chen, Y; Liu, BF; Liu, S; Liu, X; Qiu, Y; Wang, S; Xu, X; Yu, M; Zhang, G; Zhang, T; Zhao, S | 1 |
| Brouillette, WJ; Brown, GB; Zha, C | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Ablordeppey, SY; Bricker, BA; Etukala, JR; Eyunni, SV; Huang, XP; Kang, HJ; Ofori, E; Onyameh, EK; Roth, BL; Zhu, XY | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Benachour, N; Vanderheyden, PML | 1 |
| Bouvier, M; Deng, H; Dsouza, NR; Johnson, ME; Lee, H; Ren, J | 1 |
| Cao, X; Chen, Y; Liu, BF; Liu, X; Qiu, Y; Xu, X; Yu, M; Zhang, G; Zhang, L; Zhang, Y | 1 |
| Dismukes, K; Mulder, AH | 1 |
| Gommeren, W; Laduron, PM; Leysen, JE | 2 |
| Govoni, S; Spano, PF; Trabucchi, M | 1 |
| Colpaert, FC; Janssen, PA; Niemegeers, CJ | 1 |
| Hanin, I; Sherman, KA; Zigmond, MJ | 1 |
| Belmaker, RH; Ebstein, RP; Pickholz, D | 1 |
| Monti, JM | 1 |
| Ling, NC; Overstreet, DH; Pedigo, NW; Ragan, P; Reisine, TD; Schallert, T; Yamamura, HI | 1 |
| Freed, WJ; Neckers, LM; Perlow, MJ; Rosenblatt, JE; Shore, D; Wyatt, RJ | 1 |
| Head, M; Lal, H; Mantione, C; Puri, S; Valentino, D | 1 |
| Seeman, P; Sinclair, D; Titeler, M; Weinreich, P | 1 |
| Clement-Cormier, YC; George, RJ | 1 |
| Coupet, J; Rauh, CE | 1 |
| List, SJ; Seeman, P | 1 |
| Meltzer, HY; So, R | 1 |
| Laduron, PM; Leysen, JE | 1 |
| Bischoff, S; Korf, J; Scatton, B | 1 |
| Creese, I; Snyder, SH; Stewart, K | 1 |
| Glowinski, J; Hamon, M; Herbet, A; Nelson, DL; Pichat, L | 1 |
| Leysen, JE | 1 |
| Czlonkowski, A; Herz, A; Höllt, V | 1 |
| Bidzinski, A; Hauptmann, M; Jerlicz, M; Kostowski, W | 1 |
| Laduron, PM; Leysen, JE; Niemegeers, CJ; Tollenaere, JP | 1 |
| Bunney, WE; Pert, A; Pert, CB; Rosenblatt, JE; Sivit, C | 1 |
| Baez, LA; Burt, DK; Granneman, J; Shanklin, C | 1 |
| Angeby, T; Haglund, L; Köhler, C; Ogren, SO | 2 |
| Gardner, EL; Horowitz, SG; Makman, MH; Mishra, RK; Thal, L; Varmuza, S | 1 |
| Klemm, N; Kuhar, MJ; Malouf, AT; Murrin, LC | 1 |
| Howlett, DR; Nahorski, SR | 1 |
| Fibiger, HC; Lee, T; Nagy, JI; Seeman, P | 1 |
| Farley, IJ; Hornykeiwicz, O; Lee, T; Seeman, P; Tourtellotte, WW | 1 |
| Seeman, P; Titeler, M | 2 |
| Garau, L; Govoni, S; Spano, PF; Stefanini, E; Trabucchi, M | 1 |
| Maj, J; Palider, W; Rawłów, A | 1 |
| Carlson, KR; Eibergen, RD | 2 |
| Creese, I; Snyder, SH | 1 |
| Engle, DJ; Rowland, N | 1 |
| Antelman, SM; Szechtman, H | 1 |
| Meltzer, HY; Stockmeier, CA | 1 |
| LaHoste, GJ; Marshall, JF | 1 |
| Gommeren, W; Janssen, PA; Janssen, PM; Leysen, JE; Pauwels, PJ; Wynants, J | 1 |
| Blier, P; de Montigny, C; Debonnel, G; Monnet, FP | 1 |
| Choudhary, MS; Craigo, S; Roth, BL | 1 |
| de Montigny, C; Debonnel, G; Fournier, A; Monnet, FP | 1 |
| Iwata, S; Izumi, K; Nomoto, M | 1 |
| Belknap, JK; de Paulis, T; Janowsky, A; Kinzie, JM; Neve, KA; Taylor, B | 1 |
| Oliveira, CR; Palmeira, CM | 1 |
| Bendriem, B; Dewey, SL; Fowler, JS; Hitzemann, R; Logan, J; Raulli, R; Schlyer, DJ; Shiue, CY; Volkow, ND; Wolf, AP | 1 |
| Barker, EL; Burris, KD; Sanders-Bush, E | 1 |
| Albrecht, S; Walter, RD | 1 |
| Lee, T; Schmidt, MH | 1 |
| Engel, JA; Hulthe, P; Johannessen, K; Söderpalm, B; Svensson, L | 1 |
| Elazar, Z; Fuchs, S | 1 |
| Krowicki, ZK | 1 |
| McLoughlin, JV; Wheatley, AM | 1 |
| Pèzzola, A; Popoli, P; Sagratella, S; Scotti de Carolis, A | 1 |
| Machen, VL; Swaiman, KF | 1 |
| Schaus, JM; Seeman, P | 1 |
| Benedetto, P; Feigenblum, D; Filer, D; Goldstein, M; Lew, JY; Tang, D; Zawadzka, H | 1 |
| Bajwa, SB; Mishra, RK; Morency, MA; Srivastava, LK | 1 |
| Courtney, ND; Howlett, AC; Westfall, TC | 1 |
| Fields, JZ; Gordon, JH | 2 |
| Coenen, HH; Hamacher, K; Heiss, WD; Herholz, K; Huber, M; Karbe, H; Lövenich, A; Stöcklin, G; Wienhard, K | 1 |
| Bobeldijk, M; Boer, GJ; de Bruin, K; Erdtsieck-Ernste, E; Feenstra, MG; Maas, MA; van Royen, EA; Verhoeff, NP | 1 |
| Coen, KM; Corrigall, WA | 1 |
| Patterson, TA; Schenk, JO | 1 |
| Ashby, CR; Wang, RY | 1 |
| Linseman, MA | 1 |
| Kobayashi, T; Shimizu, H; Toru, M | 1 |
| Davies, M; Fletcher, PJ | 1 |
| De Montigny, C; Debonnel, G; Junien, JL; Monnet, FP | 1 |
| Amdur, RL; Carvey, PM; Kao, LC; Klawans, HL; Lin, DH; Nath, ST; Singh, R; Zhang, TJ | 1 |
| Buck, E; Rommelspacher, H; Wolffgramm, J | 1 |
| Laing, JC; Young, RJ | 1 |
| Bolger, MB; Flurkey, K; Laduron, P; Linthicum, DS; Michiels, M; Simmons, RD | 1 |
| Burki, HR | 1 |
| Kwong, LL; Peroutka, SJ; Tecott, LH; Uhr, S | 1 |
| Heyer, EJ | 1 |
| Fowler, JS; Logan, J; Shiue, CY; Wolf, AP | 1 |
| Jenner, P; Marsden, CD; Rose, S; Weller, ME | 1 |
| Carvalho, AP; Duarte, EP; Oliveira, CR | 1 |
| Bigornia, L; Napp, D; Ryan, KA; Schneider, AS; Suozzo, M | 1 |
| Fuchs, S; Kanety, H | 1 |
| Kane, JM; Kinon, BJ | 1 |
| Barros, HT; Dixon, LM; Nobrega, JN; Troncone, LR | 1 |
| Szczepanik, AM; Wilmot, CA | 1 |
| Aravagiri, M; Ellison, GD; See, RE | 1 |
| Asano, M; Kumazawa, T; Seno, H; Suzuki, O | 1 |
| Barouche, F; Brodie, JD; Cooper, TB; Fowler, JS; Rotrosen, J; Shiue, CY; Wolf, AP; Wolkin, A | 1 |
| Chivers, JK; Jenner, P; Marsden, CD; Reavill, C | 2 |
| Berghoff, W; Coughenour, LL; Courtland, GG; Myers, SL; Pugsley, TA; Shih, YH; Stewart, SF | 1 |
| Arnett, CD; Fowler, JS; Logan, J; Shiue, CY; Watanabe, M; Wolf, AP | 1 |
| Madras, BK; Seeman, P | 1 |
| Camillo, MA; DeLucia, R; Scavone, C | 1 |
| Horisaka, K; Sugimoto, Y; Yamada, J | 1 |
| Hyslop, DK; Shukla, UA; Taylor, DP; Westrick, ML | 1 |
| Carvalho, AP; Carvalho, CA; Leysen, JE; Lima, MC; Oliveira, CR | 1 |
| Akiyama, K; Otsuki, S; Sato, M; Yamada, N | 1 |
| Benavidès, J; Dubois, A; Savasta, M; Scatton, B | 1 |
| Hedreen, JC; London, ED; Su, TP; Weissman, AD | 1 |
| Arnett, CD; Fowler, JS; Shiue, CY; Watanabe, M; Wolf, AP | 1 |
| Klassen, NE; Zharkovskiĭ, AM; Zharkovskiĭ, TA | 1 |
| Parkinson, D | 1 |
| Büge, A; Oelssner, W; Peinhardt, G | 1 |
| Ko, GN; Korpi, ER; Linnoila, M | 1 |
| McMillen, BA | 1 |
| Andree, TH; Koenig, JI; Meltzer, HY; Mikuni, M; Tong, CY | 1 |
| Barone, D; Peruzzi, M; Pugnetti, P; Restelli, A | 1 |
| Andorn, AC | 1 |
| Krska, J; Sampath, G; Shah, A; Soni, SD | 1 |
| Harada, T; Otsuki, S; Sato, M | 1 |
| Altar, CA; Neale, RF; Stone, GA; Wasley, AM | 1 |
| Blair, D; Matthews, RT; McMillen, BA; Sallis, R | 1 |
| Heiss, WD; Laufer, P; Moerlein, SM; Pawlik, G; Stöcklin, G; Wienhard, K | 1 |
| Broussolle, EP; Dannals, RF; Gjedde, A; Kuhar, MJ; Links, JM; Malat, J; O'Tuama, LA; Pearlson, GD; Ravert, HT; Snyder, SH; Tamminga, CA; Toung, JK; Tune, LE; Wagner, HN; Williams, JA; Wilson, AA; Wong, DF | 1 |
| Korf, J; Sebens, JB | 1 |
| Hyttel, J | 1 |
| Suzuki, S; Yamazaki, M | 1 |
| Csernansky, JG; Hollister, LE; Prosser, ES | 1 |
| Dhawan, BN; Gulati, A; Srimal, RC | 1 |
| Aghajanian, GK; Rasmussen, K | 1 |
| Forler, C; Fozard, JR; Middlemiss, DN; Tricklebank, MD | 1 |
| Dannals, RF; Douglass, KH; Gjedde, A; Kuhar, MJ; Links, JM; Wagner, HN; Wong, DF | 1 |
| Allikmets, L; Maimets, M; Nurk, A; Soosaar, A; Vasar, E | 1 |
| Fahn, S; Reches, A; Traub, M; Wagner, HR | 1 |
| Battaglia, G; Creese, I; Norman, AB | 1 |
| Blume, AJ; Kazmi, SM; Mishra, RK; Srivastava, LK | 1 |
| Liskowsky, DR; Potter, LT | 1 |
| Lambert, G; Monroe, PJ; Nelson, DL; Yamamura, HI | 1 |
| Bijak, M; Smiałowski, A | 1 |
| Agnati, LF; Aronsson, M; Benfenati, F; Farabegoli, C; Fuxe, K; Goldstein, M; Meller, E; Pich, EM | 1 |
| Arnett, CD; Barouche, F; Brodie, JD; Fowler, JS; MacGregor, RR; Russell, JA; Shiue, CY; Smith, M; Wolf, AP; Wolkin, A | 1 |
| David, C; Elazar, Z; Fuchs, S; Kanety, H | 1 |
| Andreasen, NC; Carson, R; Diksic, M; Evans, A; Farde, L; Gjedde, A; Hakim, A; Lal, S; Nair, N; Sedvall, G | 1 |
| Arbilla, S; Bartholini, G; Fage, D; Langer, SZ; Oblin, A; Scatton, B; Zivkovic, B | 1 |
| Moon, SL | 2 |
| Antonian, E; Antonian, L; Murphy, RB; Schuster, DI | 1 |
| Fujiwara, Y; Harada, T; Kashihara, K; Ogawa, T; Otsuki, S; Sato, M | 1 |
| Contreras, ML; Contreras, PC; Gehlert, DR; O'Donohue, TL; Quirion, R | 1 |
| Crocker, AD; Crocker, JM; Overstreet, DH | 1 |
| Burchill, SA; Thody, AJ | 1 |
| Csernansky, JG; Glick, S; Mellentin, J | 1 |
| Breese, GR; Criswell, HE; Duncan, GE; McCown, TJ; Mueller, RA; Paul, IA | 1 |
| Atmadja, S; Fibiger, HC; Lee, N; MacLennan, AJ | 1 |
| Felder, RA; Jose, PA; Kanadjian, M; Nakamura, KT; Robillard, JE | 1 |
| Bohmaker, K; Friedhoff, AJ; Goldstein, M; Meller, E; Schweitzer, JW | 1 |
| Jenner, P; Marsden, CD; Rupniak, NM | 1 |
| Demenge, P; Feuerstein, C; Guerin, B; Mouchet, P; Silice, C | 1 |
| Belfroid, RD; Heerkens, CB; Van der Krogt, JA; Van Valkenburg, CF | 1 |
| Anderson, D; Gordon, J; Herbster, G; Koller, W; Wack, R | 1 |
| Frey, JM; Huffman, RD; Morgan, WW; Ticku, MK | 1 |
| Dorris, RL | 2 |
| Coper, H; Fuchs, V; Rommelspacher, H | 1 |
| Fischer, EG; Kornhuber, HH; von Kirchbach, A | 1 |
| Kohjimoto, Y; Kuwaki, T; Nomura, Y; Ono, T; Satoh, H; Shibayama, F; Shirakawa, K | 1 |
| Cooper, CW; Critcher, EC; Kirkpatrick, B; Lewis, MH; Mailman, RB; Twery, MJ | 1 |
| Artalejo, AR; García, AG; González, MC; Hervás, PP; Montiel, C | 1 |
| Beart, PM; de Vries, DJ | 1 |
| Govoni, S; Lucchi, L; Memo, M; Missale, C; Spano, PF; Trabucchi, M | 1 |
| Cullen, M; Kazmi, SM; Mishra, RK; Rajakumar, G; Ramwani, J; Ross, GM; Srivastava, LK | 1 |
| Jenner, P; Marsden, CD; Simpson, MD | 2 |
| Fahn, S; Hassan, MN; Higgins, D; Kuhn, C; Reches, A | 1 |
| Baron, JC; Cambon, H; D'Antona, R; Duquesnoy, N; Loc'h, C; Mazière, B; Sgouropoulos, P | 1 |
| Segawa, T; Toide, K; Unemi, N | 1 |
| Angeby-Möller, K; de Paulis, T; Hall, H; Johansson, L; Kumar, Y; Ogren, SO; Rämsby, S; Sällemark, M | 1 |
| Chester, NA; Menking, D; Shih, TM; Valdes, JJ; Whalley, C | 1 |
| Israel, JM; Jaquet, P; Vincent, JD | 1 |
| Hsu, LL; Moroi, K | 1 |
| Locatelli, V; Müller, EE; Parati, EA; Parenti, M; Penalva, A; Tamminga, C | 1 |
| Hurd, SM; McClure, WO; Randall, PK; Severson, JA | 1 |
| Fleminger, S; Hall, MD; Jenner, P; Kilpatrick, G; Mann, S; Marsden, CD; Rupniak, NM | 2 |
| Assandri, A; Barone, D; Galliani, G; Garattini, S; Luzzani, F; Mennini, T | 1 |
| Randall, PK; Yurek, DM | 1 |
| Asano, K; Kadokawa, T; Karasawa, T; Ochi, Y; Oka, M; Terauchi, Y | 1 |
| Fayle, P; Jackson, DM; Jenkins, OF; Lafferty, PA | 1 |
| Hruska, RE | 1 |
| Abbott, WM; Juszczak, R; Strange, PG; Worrall, S | 1 |
| Simasko, SM; Weiland, GA | 1 |
| Burchinsky, SG | 1 |
| Lee, T; Seeman, P | 2 |
| Creese, I | 1 |
| Greeley, GH; Jahnke, G; Kizer, JS; Nicholson, G; Prange, AJ; Youngblood, WW | 1 |
| Asano, T; Goldstein, M; Lew, JY; Ueta, K | 1 |
| Marshall, AM; Mishra, RK | 1 |
| Hirano, M; Kim, JS; Kojima, M; Matsumoto, T; Nakahara, T; Uchimura, H | 1 |
| Snyder, SH | 1 |
| Lader, SR | 1 |
| Chiu, S; Mishra, RK; Paulose, CS | 2 |
| Dawbarn, D; Pycock, C | 1 |
| Carino, MA; Horita, A; Lai, HC | 1 |
| Fuller, RW; Snoddy, HD | 1 |
| Dyer, R; Hall, MD; Jenner, P; Leigh, N; Marsden, CD; Rupniak, NM | 1 |
| Carino, MA; Horita, A; Lai, H | 1 |
| Fuller, RW; Hemrick-Luecke, SK; Perry, KW | 1 |
| Belfroid, RD; Van Der Krogt, JA; Van Valkenburg, CF | 1 |
| Akiyama, K; Otsuki, S; Sato, M; Yamashita, M | 1 |
| Bischoff, S; Ortmann, R; Waldmeier, PC | 1 |
| Fleminger, S; Jenner, P; Marsden, CD | 1 |
| Kostowski, W; Płaźnik, A | 1 |
| Costall, B; Dannenburg, WN; Johnson, DN; Naylor, RJ | 1 |
| Christensen, AV; Hyttel, J | 1 |
| Fleminger, S; Hall, MD; Jenner, P; Kerwin, R; Marsden, CD; Murugaiah, K; Rupniak, NM | 1 |
| Fleminger, S; Hall, MD; Jenner, P; Marsden, CD; Rupniak, NM | 1 |
| Seeman, P; Ulpian, C | 1 |
| Mishra, RK | 1 |
| Bhargava, HN | 3 |
| Lerer, B | 1 |
| Wagner, HN | 1 |
| Cook, L; Tam, SW | 1 |
| Angeby, K; Florvall, L; Hall, H; Köhler, C; Lindbom, LO; Magnusson, O; Ogren, SO | 1 |
| Robinson, HE; Severson, JA; Simpson, GM | 1 |
| Bacopoulos, NG | 2 |
| Agrawal, AK; Bondy, SC | 1 |
| Carlson, KR; Seeger, TF | 1 |
| Marshall, JF; Neve, KA | 1 |
| Agid, Y; Bokobza, B; Javoy-Agid, F; Montfort, JC; Ruberg, M | 1 |
| Korpi, ER; Wyatt, RJ | 1 |
| MacKenzie, RG; Zigmond, MJ | 1 |
| Curtin, J; Fields, J; Koller, W | 1 |
| Fahn, S; Jackson, V; Reches, A; Wagner, HR | 1 |
| Bannet, J; Belmaker, RH; Ebstein, RP; Hershkowitz, M | 1 |
| Covelli, V; Lucchi, L; Petkov, VV; Spano, PF; Trabucchi, M | 1 |
| Bloom, FE; Magistretti, PJ; Shoemaker, WJ; Staunton, DA | 1 |
| Bloom, FE; Deyo, SN; Magistretti, PJ; Shoemaker, WJ; Staunton, DA | 1 |
| Köhler, C | 1 |
| Levine, AS; Morley, JE; Rowland, NE | 1 |
| Mjörndal, T; Persson, SA | 1 |
| Crocker, AD; Overstreet, DH | 1 |
| Fibiger, HC; Jakubovic, A; Pittman, KJ | 1 |
| Barkai, AI; Fahn, S; Jackson, V; Reches, A; Wagner, HR; Yablonskaya-Alter, E | 1 |
| Lee, EK; Tamminga, CA; Walters, JR; Waszczak, BL | 1 |
| Hall, MD; Jenner, P; Kilpatrick, G; Marsden, CD; Rupniak, NM | 1 |
| Dence, CS; Kilbourn, MR; Maeda, M; Saji, H; Tewson, TJ; Welch, MJ | 1 |
| Bohmaker, K; Friedhoff, AJ; Meller, E | 1 |
| Allikmets, L; Maimets, M; Nurk, A; Vasar, E | 1 |
| Allikmets, LKh; Avrutskiĭ, GIa; Beliakov, AV; Neduva, AA; Zharkovskiĭ, AM | 1 |
| Koller, WC | 1 |
| Bédard, PJ; Boucher, R; Daigle, M; Di Paolo, T | 1 |
| Diamond, BI; Gordon, JH | 1 |
| Matvienko, OA; Nurk, AM; Zharkovskiĭ, AM | 1 |
| Flohé, L; Hennies, HH; Hess, V | 1 |
| Eckelman, WC; Gibson, RE | 1 |
| Kilbourn, MR; Mintun, MA; Raichle, ME; Welch, MJ | 1 |
| Gossuin, A; Laduron, PM; Maloteaux, JM; Waterkeyn, C | 1 |
| Kilbourn, MR; Mathias, CJ; Mintun, MA; Raichle, ME; Welch, MJ | 1 |
| Agnati, LF; Battistini, N; Benfenati, F; Fuxe, K; Toffano, G; Zini, I | 1 |
| Idoipe, A; Idoipe, C; Sanz, F | 1 |
| Benson, DI; Kuhn, CM; Meyerson, LR; Stanley, M; Virgilio, J; Wazer, D | 1 |
| Bartus, RT; Beer, B; Clody, D; Finch, C; Joseph, JA; Morgan, D; Sesack, S | 1 |
| Bédard, P; Boucher, R; Di Paolo, T; Labrie, F | 1 |
| Maayani, S; Stollak, JS; Wilkinson, CW | 1 |
| Finch, CE; Morgan, DG; Sinha, YN | 1 |
| Bannet, J; Belmaker, RH; Ebstein, RP | 2 |
| Gardner, EL; Seeger, TF; Thal, L | 1 |
| Meller, E | 1 |
| Bannet, J; Belmaker, RH; Globus, M; Lerer, B | 1 |
| Gee, KW; Hollinger, MA; Killam, EK | 1 |
| Marshall, AM; Mishra, RK; Ramwani, J | 1 |
| Friedhoff, AJ; Friedman, E; Rosengarten, H | 1 |
| Crow, TJ; Mashal, RD; Owen, F; Poulter, M; Veall, N; Zanelli, GD | 1 |
| Connor, TM; Fregly, MJ; Kikta, DC; Threatte, RM | 1 |
| Bockaert, J; Marchais, D | 1 |
| Zapata, P; Zuazo, A | 1 |
| Fahn, S; Jackson, V; Jiang, D; Reches, A; Wagner, HR | 1 |
| Friedhoff, AJ; Schwartz, R; Schweitzer, JW | 1 |
| Achilli, G; Algeri, S; Cimino, M; Perego, C; Ponzio, F; Vantini, G | 1 |
| Audiau, F; Carpy, A; Guérémy, C; Le Fur, G; Léger, JM; Uzan, A | 1 |
| Kuno, T; Mita, T; Nakai, H; Tanaka, C | 1 |
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| Barbaccia, ML; Bosio, A; Lucchi, L; Spano, PF; Trabucchi, M | 1 |
| Heffner, TG; Stricker, EM; Zigmond, MJ | 1 |
| Airaghi, ML; Lucchi, L; Memo, M; Spano, PF; Trabucchi, M | 1 |
| Arita, T; Koyama, T; Miyazaki, K; Oka, I; Yamashita, I | 1 |
| Bischoff, S | 1 |
| Bannet, J; Belmaker, RH; Ebstein, RP; Gillis, S | 1 |
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| Battaini, F; Memo, M; Spano, PF; Trabucchi, M | 1 |
| D'Angelo, L; Monti, JM | 1 |
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| Cocchi, D; Gil-Ad, I; Locatelli, V; Müller, EE; Parenti, M; Stefanini, E | 1 |
| Argiolas, A; Collu, R; Devoto, P; Marchisio, AM; Stefanini, E; Vernaleone, F | 1 |
| Kayaalp, SO; Neff, NH | 1 |
| Hruska, RE; Ludmer, LM; Silbergeld, EK | 1 |
| Lucchi, L; Memo, M; Spano, PF; Trabucchi, M | 1 |
| Neale, SE; Saelens, JK; Selwyn, M; Simke, JP; Weeks, BJ | 1 |
| Eriksson, L; Farde, L; Halldin, C; Nordström, AL | 1 |
| Gardner, B; Strange, PG | 1 |
| Consolo, S; Costi, P; Kleinrok, Z; Kolasa, K; Zecca, L | 1 |
| Barrett, RJ; Caul, WF; Huffman, EM; Jones, JR; Strand, EJ | 1 |
| Asghari, V; Buchwaldt, S; Jovanovic, V; Paterson, A; Sanyal, S; Van Tol, HH | 1 |
| Iida, Y; Iwasaki, Y; Konishi, J; Magata, Y; Saji, H; Tanahashi, K; Yokoyama, A; Yonekura, Y | 1 |
| Brodie, JD; Fowler, JS; Schlyer, DJ; Smith, MR; Volkow, ND; Wang, GJ; Warner, D; Wolf, AP; Yousef, KA | 1 |
| Chase, GA; Dannals, RF; Links, JM; Pearlson, GD; Ravert, HT; Ross, CA; Tune, LE; Wagner, HN; Wilson, AA; Wong, DF | 1 |
| Katz, JL; Witkin, JM | 1 |
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| Cai, B; Ehrlich, GK; Frietze, W; Lem, G; Murphy, RB; Pan, YP; Schuster, DI; Singh, G; Stoupakis, G | 1 |
| Bernard, A; Cavegn, C; Chabert, C; Mills, A | 1 |
| Guenther, E; Wilsch, V; Zrenner, E | 1 |
| Fornal, CA; Jacobs, BL; Litto, WJ; Marrosu, F; Metzler, CW; Tada, K | 1 |
| Bole-Vunduk, B; Budihna, MV; Krisch, I; Lavric, B; Ocvirk, A; Pepelnak, M; Sket, D | 1 |
| Augustin, W; Sabel, BA; Schröder, H; Schröder, U | 1 |
| Chuang, DM; Kirch, DG; Li, R; Wyatt, RJ | 1 |
| Dannals, RF; Mathews, WB; Musachio, JL; Ravert, HT; Scheffel, U; Stathis, M | 1 |
| Furukawa, K; Hino, K; Karasawa, T; Kurumiya, S; Noda, Y; Ochi, Y; Oka, M; Une, T | 1 |
| Burnham, P; Louis, JC; Magal, E; Varon, S | 1 |
| Fujimaki, M; Inazuki, G; Itoh, N; Kobayashi, T; Masuzawa, N; Nakamura, H; Nakayama, H; Togashi, S | 1 |
| Barfknecht, CF; Cheng, B; Ignace, CC; Iwai, Y; Newton, RE; Schoenwald, RD; Shirolkar, S; Vidvauns, S; Xia, E | 1 |
| Ichinowatari, N; Mamiya, G; Ohtakeno, S; Watanabe, H; Watanabe, M | 1 |
| Mayfield, RD; Randall, PK; Spirduso, WW; Wilcox, RE | 1 |
| Carmon, S; David, C; Fishburn, CS; Fuchs, S | 1 |
| Barfknecht, CF; Newton, RE; Schoenwald, RD; Xia, E | 1 |
| Beckmann, H; Fritze, J; Riederer, P; Wodarz, N | 1 |
| Di Paolo, T; Falardeau, P; Rivest, R | 1 |
| Bergeron, R; de Montigny, C; Debonnel, G | 1 |
| Fukuda, T; Futamura, T; Haga, K; Ohashi, Y; Takahashi, Y; Yano, K | 1 |
| Horikawa, T; Ito, A; Nomura, Y; Okada, F; Tokumitsu, Y | 1 |
| Lynch, AM; See, RE; Sorg, BA | 1 |
| Brand, L; Castagnoli, N; Oliver, DW; Pond, SM; van der Schyf, CJ | 1 |
| Fritze, J; Riederer, P; Wodarz, N | 1 |
| Brunet, C; Cazin, JC; Cazin, M; Dine, T; Gressier, B; Luyckx, M; Odou, P; Vaiva, G | 1 |
| Amenta, F; Barili, P; Zaccheo, D | 1 |
| Liu, Y; Wolfe, SA | 1 |
| Creese, I; Florijn, WJ; Tarazi, FI | 1 |
| Gjedde, A; Meltzer, CC; Wilson, PD; Wong, DF; Young, D | 1 |
| Kołodziejczyk, K; Maj, J; Rogóz, Z; Skuza, G | 1 |
| Ichikawa, J; Meltzer, HY; Sumiyoshi, T | 1 |
| Braghiroli, L; De Feo, G; Giacomelli, S; Koppenaal, DW; Ponzianelli, A | 1 |
| Conley, RR; Tamminga, CA | 1 |
| Sabel, BA; Schroeder, H; Schroeder, U | 1 |
| De Lucia, R; Flório, JC; Frussa-Filho, R; Palermo-Neto, J; Tufik, S; Vital, MA | 1 |
| Hide, I; Hirose, T; Inoue, A; Kikuchi, T; Koga, N; Nakata, Y; Seto, M; Sugita, S | 1 |
| Mishina, M; Sakimura, K; Shimoji, K; Yamakura, T | 1 |
| Christ, G; Kaynan, A; Maayani, S; Melman, A; Rehman, J; Valcic, M | 1 |
| Bakthavachalam, V; Baldessarini, RJ; Kula, NS; Pounds, S; Tarazi, FI; True, CD; Xu, L | 1 |
| Fox, K; Lam, P; Ling, V; Shapiro, AB | 1 |
| Nowak, G; Ossowska, K; Pietraszek, M; Wardas, J; Wolfarth, S | 1 |
| Liu, ZH; Zhang, KG | 1 |
| Brust, P; Gupta, CN; Parimoo, P; Raghavan, SA; Rangisetty, JB; Sridhar, N; Srinivas, P; Subramanian, AR; Veeranjaneyulu, A | 1 |
| Geurts, M; Hermans, E; Maloteaux, JM | 1 |
| Bradley, RJ; Dwyer, DS; Liu, Y | 1 |
| Alper, RH; Gilliland, SL; Levant, B | 1 |
| Sabel, BA; Schroeder, H; Schroeder, U; Schwegler, H | 1 |
| Armogida, M; Chiacchio, S; Colzi, A; Corsini, GU; DeMontis, MG; Maggio, R; Scarselli, M | 1 |
| Bender, D; Cumming, P; Danielsen, E; Gjedde, A; Hansen, SB; Ishizu, K; Smith, DF; Wong, DF | 1 |
| Baik, JH; Borrelli, E; Dierich, A; LeMeur, M; Piazza, PV; Picetti, R; Rougé-Pont, F; Usiello, A | 1 |
| Li, Y; Matsuda, H; Yoshikawa, M | 1 |
| Breese, CR; Lee, MJ; Leonard, S; Strook, ML | 1 |
| Markova, LN; Ostroumova, TV | 1 |
| Joyce, JN | 1 |
| Fu, D; Javitch, JA; Lin, H; Strange, PG; Wilson, J | 1 |
| Benjamin, D; He, M; Shippenberg, T; Sibille, E; Toth, M | 1 |
| Gainetdinov, RR; Grekhova, TV; Rayevsky, KS; Sotnikova, TD | 1 |
| Dikic, B; Kassiou, M; Katsifis, A; Mardon, K; Mattner, F | 1 |
| Higuchi, S; Ohdo, S; Viyoch, J; Yukawa, E | 1 |
| Berardi, F; Calò, R; Colabufo, NA; Leopoldo, M; Perrone, R; Tortorella, V | 1 |
| Bridges, S; Miller, C; Thompson, TL | 1 |
| Huang, XF; Zavitsanou, K | 1 |
| Guo, H; Jin, G; Tang, Z; Xu, L; Yu, Y; Zhou, J | 1 |
| Lai, WS; Liao, RM; Lin, JY | 1 |
| BOBON, J; COLLARD, J; DELREE, C; GERNAY, JM | 1 |
| Morales, M; Oz, M; Rotondo, A; Sun, H; Zhang, L | 1 |
| Lau, YS; Meredith, GE; Petroske, E; Wang, JQ | 1 |
| Fujii, Y; Higashi, Y; Kitahara, M | 1 |
| Agovic, MS; Banerjee, SP; Lidsky, TI; Yablonsky-Alter, E | 1 |
| Akaike, A; Izumi, Y; Kume, T; Matsuo, T; Sawada, H; Takada-Takatori, Y; Wakita, S | 1 |
| Feng, Z; Hou, T; Li, Y | 1 |
10 review(s) available for spiperone and haloperidol
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
Influence of the cellular environment on ligand binding kinetics at membrane-bound targets.
Topics: Angiotensin II Type 1 Receptor Blockers; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Humans; Kinetics; Ligands; Protein Binding; Receptor, Angiotensin, Type 1; Receptors, Cell Surface; Signal Transduction | 2017 |
On the clinical relevance and methods of quantification of plasma concentrations of neuroleptics.
Topics: Animals; Antipsychotic Agents; Binding Sites; Chromatography, Gas; Corpus Striatum; Ethnicity; Follow-Up Studies; Haloperidol; Humans; Kinetics; Orosomucoid; Prolactin; Radioligand Assay; Rats; Schizophrenia; Spiperone; Thioridazine | 1985 |
Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum.
Topics: Adult; Corpus Striatum; Haloperidol; Humans; National Institute of Mental Health (U.S.); Raclopride; Receptors, Dopamine; Receptors, Dopamine D2; Salicylamides; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed; United States | 1988 |
Neurotransmitter receptors in the central nervous system and aging: pharmacological aspect (review).
Topics: Adenylyl Cyclases; Aging; Animals; Brain; Desipramine; Dopamine; Dopamine Antagonists; Female; Fluphenazine; Haloperidol; Humans; Male; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Cholinergic; Receptors, Dopamine; Receptors, GABA-A; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Serotonin; Reserpine; Scopolamine; Spiperone; Tetrahydronaphthalenes; Tissue Distribution; Tritium | 1984 |
Central nervous system dopamine receptors.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Brain; Dopamine; Guanine Nucleotides; Haloperidol; Humans; Receptors, Dopamine; Schizophrenia; Spiperone | 1980 |
Minireview. Stress induced eating.
Topics: Animals; Bombesin; Bruxism; Cholecystokinin; Corticotropin-Releasing Hormone; Feeding and Eating Disorders; Feeding Behavior; Food Preferences; Haloperidol; Humans; Hyperphagia; Latency Period, Psychological; Lesch-Nyhan Syndrome; Mastication; Nail Biting; Narcotics; Receptors, Dopamine; Reward; Spiperone; Stress, Physiological; Sucking Behavior | 1983 |
Radioreceptor labeling of pre- and postsynaptic dopamine receptors.
Topics: Animals; Apomorphine; Binding Sites; Haloperidol; Humans; Parkinson Disease; Radioligand Assay; Receptors, Dopamine; Spiperone; Synapses | 1980 |
The application of neuroimaging techniques to drug development.
Topics: Antipsychotic Agents; Brain; Brain Chemistry; Carbon Radioisotopes; Cerebrovascular Circulation; Deoxyglucose; Diagnostic Imaging; Drug Industry; Drugs, Investigational; Fluorodeoxyglucose F18; Haloperidol; Humans; Ketamine; Magnetic Resonance Imaging; Mental Disorders; Neuropharmacology; Receptors, Dopamine; Spiperone; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 1997 |
414 other study(ies) available for spiperone and haloperidol
| Article | Year |
|---|---|
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Blotting, Northern; Brain; Cell Line; Cell Membrane; Cloning, Molecular; Dopamine; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Oligonucleotide Probes; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D5; RNA, Messenger; Sequence Homology, Nucleic Acid; Transfection | 1991 |
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
Topics: Amino Acid Sequence; Animals; Antipsychotic Agents; Base Sequence; Brain Chemistry; Cell Line; Cloning, Molecular; Cricetinae; DNA; DNA Restriction Enzymes; Dopamine; Guanylyl Imidodiphosphate; Molecular Sequence Data; Nucleic Acid Hybridization; Polymerase Chain Reaction; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Sequence Homology, Nucleic Acid; Tissue Distribution | 1990 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Catalepsy; Cebus; Chemical Phenomena; Chemistry; Haloperidol; Hypothalamus; Male; Mice; Motor Activity; Rats; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Muscarinic; Saimiri; Spiro Compounds; Structure-Activity Relationship | 1985 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Characterization of the human dopamine D3 receptor expressed in transfected cell lines.
Topics: Animals; Arachidonic Acid; Binding, Competitive; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agents; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Inositol Phosphates; Mice; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes; Transfection | 1994 |
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
Topics: Animals; Antipsychotic Agents; Cell Line; Molecular Structure; Rats; Receptors, Serotonin | 1994 |
Conformational analysis, pharmacophore identification, and comparative molecular field analysis of ligands for the neuromodulatory sigma 3 receptor.
Topics: Animals; Ligands; Models, Molecular; Molecular Conformation; Receptors, sigma; Rodentia; Structure-Activity Relationship; Tetrahydronaphthalenes | 1994 |
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Cyclic AMP; DNA; Drosophila; Enzyme Activation; Humans; Intestinal Mucosa; Mice; Molecular Sequence Data; Myocardium; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; CHO Cells; Cricetinae; Cyclic AMP; DNA; Genomic Library; Kinetics; Lysergic Acid Diethylamide; Mianserin; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; Organ Specificity; Rats; Receptors, Serotonin; Restriction Mapping; Serotonin; Serotonin Receptor Agonists; Transfection | 1993 |
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
Topics: Adenylyl Cyclases; Animals; Behavior, Animal; Binding, Competitive; Colforsin; Cyclic AMP; Electrophysiology; Enzyme Activation; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Piperazines; Protein Binding; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Stereoisomerism; Structure-Activity Relationship | 1997 |
Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b).
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cyclic AMP; DNA, Complementary; Humans; Molecular Sequence Data; Placenta; Radioligand Assay; Rats; Receptors, Serotonin; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid | 1997 |
[3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor.
Topics: Adrenergic alpha-Antagonists; Benzofurans; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Imidazoles; Radioligand Assay; Receptor, Serotonin, 5-HT2B; Receptors, Serotonin; Serotonin Antagonists; Transfection; Tritium; Yohimbine | 1998 |
Creation of a constitutively activated state of the 5-hydroxytryptamine2A receptor by site-directed mutagenesis: inverse agonist activity of antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; COS Cells; Mutagenesis, Site-Directed; Phosphatidylinositols; Protein Conformation; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Structure-Activity Relationship | 1998 |
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes | 1998 |
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ligands; Models, Molecular; Pyrilamine; Radioligand Assay; Structure-Activity Relationship; Tetrahydronaphthalenes | 1999 |
Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.
Topics: Algorithms; Binding Sites; Computational Biology; Crystallography, X-Ray; Databases, Protein; Humans; Kinetics; Ligands; Lipid Bilayers; Models, Molecular; Molecular Conformation; Mutation; Receptors, Dopamine D2; Receptors, Dopamine D3; Reproducibility of Results; Solvents; Structure-Activity Relationship; Tetrahydronaphthalenes; Water | 2003 |
Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.
Topics: Animals; Binding Sites; Biochemistry; Cells, Cultured; Drug Evaluation, Preclinical; Guinea Pigs; Humans; Inhibitory Concentration 50; Ligands; Piperazines; Piperidines; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Serotonin 5-HT1 Receptor Agonists; Sigma-1 Receptor; Structure-Activity Relationship | 2005 |
Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes.
Topics: Amino Acid Sequence; Animals; Cattle; Conserved Sequence; Dopamine Antagonists; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Mutation; Protein Conformation; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Rhodopsin; Sequence Alignment; Spiperone | 2005 |
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.
Topics: Amides; Animals; Cell Line; Guinea Pigs; Humans; Ileum; Male; Muscle Contraction; Muscle, Smooth; Piperazines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists; Structure-Activity Relationship; Tetrahydronaphthalenes | 2007 |
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation.
Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG | 2008 |
Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT).
Topics: Animals; Male; Molecular Structure; Piperidines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, sigma; Vesicular Acetylcholine Transport Proteins | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile.
Topics: Animals; Antipsychotic Agents; Berberine; Berberine Alkaloids; CHO Cells; Cricetinae; Cricetulus; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Microwaves; Motor Activity; Protein Binding; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D1; Receptors, Dopamine D2; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship | 2013 |
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Biological Availability; Coumarins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; In Vitro Techniques; Isoxazoles; Lethal Dose 50; Mice; Motor Activity; Prolactin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship; Weight Gain | 2013 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.
Topics: Animals; Dopamine Agents; Humans; Ligands; Proton Magnetic Resonance Spectroscopy; Receptors, Dopamine D2 | 2016 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/HLA-A2 interactions.
Topics: Adenoviridae; Adenovirus E3 Proteins; Antiviral Agents; Dose-Response Relationship, Drug; Drug Discovery; HLA-A2 Antigen; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Small Molecule Libraries; Structure-Activity Relationship | 2018 |
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.
Topics: Animals; Antipsychotic Agents; Body Weight; Chemistry Techniques, Synthetic; Drug Design; Ether-A-Go-Go Potassium Channels; Heterocyclic Compounds; Memory; Mice; Piperazine; Rats; Schizophrenia; Structure-Activity Relationship; Tissue Distribution | 2018 |
Effects of neuroleptics on release of 3H-dopamine from slices of rat corpus striatum.
Topics: Animals; Antipsychotic Agents; Apomorphine; Chlorpromazine; Cocaine; Corpus Striatum; Dopamine; Electric Stimulation; Fluphenazine; Haloperidol; Male; Rats; Spiperone | 1977 |
Spiperone: a ligand of choice for neuroleptic receptors. 1. Kinetics and characteristics of in vitro binding.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Butyrophenones; Corpus Striatum; Female; Haloperidol; Hot Temperature; In Vitro Techniques; Kinetics; Ligands; Rats; Receptors, Drug; Spiperone; Subcellular Fractions | 1978 |
[3H]Haloperidol and [3H]spiroperidol binding in rat striatum during ageing.
Topics: Adenylyl Cyclases; Aging; Animals; Binding Sites; Butyrophenones; Corpus Striatum; Dopamine; Haloperidol; In Vitro Techniques; Male; Rats; Spiperone | 1978 |
Neuroleptic interference with the cocaine cue: internal stimulus control of behavior and psychosis.
Topics: Amphetamine; Animals; Antipsychotic Agents; Behavior; Cocaine; Cues; Drug Interactions; Haloperidol; Humans; Male; Pimozide; Psychotic Disorders; Rats; Spiperone | 1978 |
The effect of neuroleptics on acetylcholine concentration and choline uptake in striatum: Implications for regulation of acetylcholine metabolism.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Brain Chemistry; Cerebral Cortex; Choline; Corpus Striatum; Fluphenazine; Haloperidol; Male; Rats; Spiperone | 1978 |
Distinction between dopaminergic and serotonergic components of neuroleptic binding sites in limbic brain areas.
Topics: Animals; Antipsychotic Agents; Binding Sites; Corpus Striatum; Dopamine; Haloperidol; In Vitro Techniques; Limbic System; Nucleus Accumbens; Olfactory Bulb; Rats; Serotonin; Spiperone | 1979 |
Dopamine receptor changes after long-term haloperidol treatment in rats.
Topics: Animals; Binding Sites; Corpus Striatum; Haloperidol; Rats; Receptors, Dopamine; Spiperone; Time Factors | 1979 |
The effects of neuroleptics with central dopamine and noradrenaline receptor blocking properties in the L-DOPA and (+)-amphetamine-induced waking EEG in the rat.
Topics: Animals; Antipsychotic Agents; Dextroamphetamine; Electroencephalography; Haloperidol; Levodopa; Male; Norepinephrine; Pimozide; Rats; Receptors, Adrenergic; Receptors, Dopamine; Sleep; Spiperone; Wakefulness | 1979 |
Inhibition of in vivo 3H-spiperone binding by the proposed antipsychotic Des-Tyr1-gamma-endorphin.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Blepharoptosis; Brain; Butyrophenones; Catalepsy; Endorphins; Haloperidol; Humans; Male; Morphine; Peptide Fragments; Posture; Rats; Spiperone | 1979 |
Effects of chronic haloperidol on caudate 3H-spiroperidol binding in lesioned rats.
Topics: Animals; Butaclamol; Butyrophenones; Caudate Nucleus; Cerebral Cortex; Haloperidol; Kainic Acid; Rats; Receptors, Dopamine; Spiperone | 1979 |
Enhancement of morphine analgesia after acute and chronic haloperidol.
Topics: Animals; Behavior, Animal; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Male; Morphine; Naloxone; Pain; Rats; Receptors, Opioid; Spiperone | 1979 |
Multiple receptors for brain dopamine.
Topics: Animals; Binding, Competitive; Butaclamol; Cattle; Caudate Nucleus; Dihydroergotoxine; Dopamine; Haloperidol; Norepinephrine; Receptors, Dopamine; Spiperone | 1978 |
Multiple dopamine binding sites: subcellular localization and biochemical characterization.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Binding, Competitive; Caudate Nucleus; Haloperidol; Kinetics; Male; Rats; Receptors, Dopamine; Spiperone; Subcellular Fractions | 1979 |
3H-Spiroperidol binding to dopamine receptors in rat striatal membranes: influence of loxapine and its hydroxylated metabolites.
Topics: Animals; Butyrophenones; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzoxazepines; Haloperidol; Hydroxylation; In Vitro Techniques; Loxapine; Membranes; Rats; Receptors, Dopamine; Spiperone | 1979 |
Dopamine agonists reverse the elevated 3H-neuroleptic binding in neuroleptic-pretreated rats.
Topics: Animals; Apomorphine; Bromocriptine; Carbidopa; Corpus Striatum; Dyskinesia, Drug-Induced; Haloperidol; Levodopa; Male; Radioligand Assay; Rats; Receptors, Dopamine; Receptors, Drug; Spiperone | 1979 |
Effect of morphine, beta-endorphin and leu-enkephalin on 3H-spiroperidol binding to bovine pituitary membranes.
Topics: Animals; Binding Sites; Butaclamol; Butyrophenones; Cattle; Chlorpromazine; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Haloperidol; Membranes; Morphine; Pituitary Gland, Anterior; Spiperone | 1979 |
Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity.
Topics: Adenylyl Cyclases; Animals; Benzimidazoles; Binding Sites; Cerebral Cortex; Corpus Striatum; Dopamine; Dopamine Antagonists; Haloperidol; Homovanillic Acid; In Vitro Techniques; Piperidines; Rats; Spiperone; Tissue Distribution | 1979 |
Dopamine metabolism, spiperone binding and adenylate cyclase activity in the adult rat hippocampus after ingrowth of dopaminergic neurones from embryonic implants.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Animals; Butyrophenones; Dopamine; Haloperidol; Hippocampus; Male; Nerve Regeneration; Norepinephrine; Rats; Receptors, Dopamine; Spiperone | 1979 |
Species variation in dopamine receptor binding.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Cattle; Caudate Nucleus; Fluphenazine; Haloperidol; Humans; In Vitro Techniques; Male; Rats; Receptors, Dopamine; Species Specificity; Spiperone; Tetrahydronaphthalenes | 1979 |
In vitro and in vivo disposition of 3H-methiothepin in brain tissues. Relationship to the effects of acute treatment with methiothepin on central serotoninergic receptors.
Topics: Adenylyl Cyclases; Animals; Brain; Dibenzothiepins; Haloperidol; Male; Membranes; Methiothepin; Rats; Receptors, Serotonin; Serotonin; Spiperone; Synaptosomes; Time Factors | 1979 |
Unitary dopaminergic receptor composed of cooperatively linked agonist and antagonist sub-unit binding sites.
Topics: Animals; Apomorphine; Binding Sites; Corpus Striatum; Female; Haloperidol; Hydroxydopamines; Kainic Acid; Kinetics; Rats; Receptors, Dopamine; Spiperone; Subcellular Fractions | 1979 |
The demonstration in vivo of specific binding sites for neuroleptic drugs in mouse brain.
Topics: Animals; Apomorphine; Brain; Catalepsy; Chlorpromazine; Dibenzocycloheptenes; Dopamine; Haloperidol; Humans; Male; Mice; Piribedil; Quinolizines; Receptors, Dopamine; Receptors, Drug; Spiperone; Structure-Activity Relationship; Tranquilizing Agents | 1977 |
Behavioral effects of neuroleptics, apomorphine and amphetamine after bilateral lesion of the locus coeruleus in rats.
Topics: Animals; Apomorphine; Behavior; Biogenic Amines; Brain Chemistry; Butyrophenones; Dextroamphetamine; Haloperidol; Humans; Locus Coeruleus; Male; Motor Activity; Rats; Spiperone; Stereotyped Behavior; Time Factors | 1977 |
Serotonergic component of neuroleptic receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Frontal Lobe; Haloperidol; Humans; In Vitro Techniques; Lysergic Acid Diethylamide; Rats; Receptors, Dopamine; Receptors, Serotonin; Seizures; Spiperone; Stereotyped Behavior; Tranquilizing Agents; Tryptamines | 1978 |
Long-term treatment with lithium prevents the development of dopamine receptor supersensitivity.
Topics: Animals; Apomorphine; Corpus Striatum; Haloperidol; Humans; Lithium; Male; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1978 |
Dopaminergic antagonism and catalepsy in the developing rat.
Topics: Aging; Animals; Catalepsy; Dopamine; Dopamine Antagonists; Female; Haloperidol; Humans; Male; Rats; Spiperone | 1979 |
Regional displacement by sulpiride of [3H]spiperone binding in vivo. Biochemical and behavioural evidence for a preferential action of limbic and nigral dopamine receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butyrophenones; Catalepsy; Haloperidol; Humans; Male; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1979 |
Dopamine antagonist binding increases in two behaviorally distinct striatal denervation syndromes.
Topics: Animals; Apomorphine; Behavior; Butyrophenones; Corpus Striatum; Denervation; Haloperidol; Humans; Hydroxydopamines; Male; Neural Pathways; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra | 1979 |
Dopamine receptor binding in vivo: the feasibility of autoradiographic studies.
Topics: Animals; Apomorphine; Autoradiography; Butaclamol; Cerebellum; Cerebral Cortex; Corpus Striatum; Haloperidol; Hippocampus; Male; Rats; Receptors, Dopamine; Spiperone | 1978 |
A comparative study of [3H]haloperidol and [3H]spiroperidol binding to receptors on rat cerebral membranes.
Topics: Animals; Binding, Competitive; Brain; Butyrophenones; Cerebellum; Cerebral Cortex; Corpus Striatum; Haloperidol; Kinetics; Limbic System; Male; Membranes; Rats; Receptors, Dopamine; Spiperone; Tranquilizing Agents | 1978 |
Direct evidence for presynaptic and postsynaptic dopamine receptors in brain.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Brain; Caudate Nucleus; Haloperidol; Hydroxydopamines; Male; Putamen; Rats; Receptors, Dopamine; Spiperone; Substantia Nigra; Synaptic Membranes | 1978 |
Binding of 3H-neuroleptics and 3H-apomorphine in schizophrenic brains.
Topics: Adult; Aged; Apomorphine; Brain; Butyrophenones; Caudate Nucleus; Cerebral Cortex; Female; Haloperidol; Humans; Male; Middle Aged; Nucleus Accumbens; Putamen; Schizophrenia; Spiperone; Tranquilizing Agents | 1978 |
Antiparkinsonian drug doses and neuroleptic receptors.
Topics: Animals; Antiparkinson Agents; Apomorphine; Bromocriptine; Cattle; Caudate Nucleus; Haloperidol; In Vitro Techniques; Receptors, Dopamine; Spiperone; Tritium | 1978 |
Dopamine receptors: pharmacological and anatomical evidences indicate that two distinct dopamine receptor populations are present in rat striatum.
Topics: Adenylyl Cyclases; Animals; Corpus Striatum; Haloperidol; Male; Rats; Receptors, Dopamine; Spiperone; Sulpiride; Time Factors | 1978 |
The effect of haloperidol, spiperone and pimozide on the flexor reflex of the hind limb of the spinal rat.
Topics: Animals; Butyrophenones; Clonidine; Denervation; Fenfluramine; Haloperidol; Hindlimb; Lysergic Acid Diethylamide; Male; Muscle Contraction; Norepinephrine; Pimozide; Rats; Receptors, Adrenergic; Receptors, Serotonin; Reflex; Serotonin; Spinal Cord; Spiperone | 1978 |
Dyskinesias in monkeys: interaction of methamphetamine with prior methadone treatment.
Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methamphetamine; Naloxone; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Stereotyped Behavior | 1976 |
Susceptibility to amphetamine-elicited dyskinesias following chronic methadone treatment in monkeys.
Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Drug Interactions; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Macaca mulatta; Male; Methadone; Methamphetamine; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Time Factors | 1976 |
A simple and sensitive radioreceptor assay for antischizophrenic drugs in blood.
Topics: Animals; Binding, Competitive; Blood Proteins; Corpus Striatum; Haloperidol; Humans; Radioimmunoassay; Radioligand Assay; Rats; Receptors, Dopamine; Spiperone; Tranquilizing Agents | 1977 |
Feeding and drinking interactions after acute butyrophenone administration.
Topics: Animals; Butyrophenones; Deoxyglucose; Drinking Behavior; Droperidol; Feeding Behavior; Food Deprivation; Haloperidol; Hunger; Insulin; Male; Rats; Salivary Glands; Spiperone; Thirst; Water Deprivation | 1977 |
Tail pinch induces eating in sated rats which appears to depend on nigrostriatal dopamine.
Topics: Animals; Behavior, Animal; Consummatory Behavior; Corpus Striatum; Depression, Chemical; Dopamine; Feeding Behavior; Haloperidol; Hydroxydopamines; Male; Norepinephrine; Phentolamine; Pimozide; Rats; Receptors, Adrenergic; Receptors, Drug; Sotalol; Spiperone; Stress, Physiological; Substantia Nigra; Time Factors | 1975 |
In vivo occupancy of dopamine receptors by antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Haloperidol; Humans; Rats; Receptors, Dopamine; Receptors, Serotonin; Spiperone | 1992 |
Dopamine supersensitivity and D1/D2 synergism are unrelated to changes in striatal receptor density.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Corpus Striatum; Dopamine; Dopamine Agents; Ergolines; Haloperidol; Male; Oxidopamine; Quinpirole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Reserpine; Spiperone; Stereotyped Behavior; Time Factors; Tritium | 1992 |
In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone.
Topics: Animals; Antipsychotic Agents; Biogenic Monoamines; Brain; Female; Haloperidol; In Vitro Techniques; Isoxazoles; Male; Neurotransmitter Agents; Piperidines; Pyrimidinones; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Risperidone; Spiperone; Tissue Distribution | 1992 |
Modulation by sigma ligands of N-methyl-D-aspartate-induced [3H]noradrenaline release in the rat hippocampus: G-protein dependency.
Topics: Animals; Calcium; Cinnamates; Cyclopropanes; Dose-Response Relationship, Drug; Ethylmaleimide; GTP-Binding Proteins; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Norepinephrine; Pertussis Toxin; Piperidines; Rats; Rats, Inbred Strains; Spiperone; Tritium; Virulence Factors, Bordetella | 1992 |
Identification of receptor domains that modify ligand binding to 5-hydroxytryptamine2 and 5-hydroxytryptamine1c serotonin receptors.
Topics: Base Sequence; Binding, Competitive; Ergolines; Haloperidol; In Vitro Techniques; Ketanserin; Molecular Sequence Data; Oligodeoxyribonucleotides; Receptors, Serotonin; Recombinant Fusion Proteins; Spiperone; Structure-Activity Relationship; Transfection | 1992 |
Neuropeptide Y potentiates the N-methyl-D-aspartate response in the CA3 dorsal hippocampus. II. Involvement of a subtype of sigma receptor.
Topics: Animals; Cinnamates; Cyclopropanes; Drug Synergism; Guanidines; Haloperidol; Hippocampus; Male; N-Methylaspartate; Neuropeptide Y; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Receptors, sigma; Spiperone | 1992 |
Upregulation of postsynaptic dopamine receptors in the striatum does not influence haloperidol-induced catalepsy in mice.
Topics: Animals; Biogenic Monoamines; Catalepsy; Corpus Striatum; Haloperidol; Kinetics; Male; Mice; Mice, Inbred Strains; Nerve Tissue Proteins; Oxidopamine; Receptors, Dopamine; Spiperone; Synapses; Up-Regulation | 1992 |
Extrastriatal dopamine D2 receptors: distribution, pharmacological characterization and region-specific regulation by clozapine.
Topics: Amphetamine; Animals; Autoradiography; Benzamides; Brain; Clozapine; Haloperidol; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1992 |
Partitioning and membrane disordering effects of dopamine antagonists: influence of lipid peroxidation, temperature, and drug concentration.
Topics: Animals; Caudate Nucleus; Diphenylhexatriene; Domperidone; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Hot Temperature; Intracellular Membranes; Lipid Peroxidation; Liposomes; Microsomes; Pimozide; Sheep; Solubility; Spiperone | 1992 |
Regional distribution and kinetics of haloperidol binding in human brain: a PET study with [18F]haloperidol.
Topics: Adult; Animals; Brain; Fluorine Radioisotopes; Haloperidol; Humans; Male; Mice; Schizophrenia; Spiperone; Tomography, Emission-Computed | 1992 |
Phosphoinositide hydrolysis linked 5-HT2 receptors in fibroblasts from choroid plexus.
Topics: Animals; Cells, Cultured; Choroid Plexus; DOM 2,5-Dimethoxy-4-Methylamphetamine; Fibroblasts; Haloperidol; Hydrolysis; Inositol Phosphates; Ketanserin; Lysergic Acid Diethylamide; Male; Mianserin; Phosphatidylinositols; Prazosin; Rabbits; Receptors, Serotonin; Serotonin; Spiperone | 1991 |
Hallucinogenic and neuroleptic drug interactions with potential neurotransmitter receptors in parasitic nematodes.
Topics: Animals; Antipsychotic Agents; Ascaris; Binding, Competitive; Diethylamines; Haloperidol; Lysergic Acid Diethylamide; Mianserin; Onchocerca; Receptors, Neurotransmitter; Spiperone | 1991 |
Investigation of striatal dopamine D2 receptor acquisition following prenatal neuroleptic exposure.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Corpus Striatum; Dose-Response Relationship, Drug; Female; Haloperidol; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Thiothixene; Trifluoperazine | 1991 |
Evidence for a role for dopamine in the diazepam locomotor stimulating effect.
Topics: alpha-Methyltyrosine; Animals; Benzazepines; Diazepam; Dopamine; Flumazenil; Haloperidol; Male; Methyltyrosines; Mice; Motor Activity; Spiperone; Stimulation, Chemical; Tyrosine 3-Monooxygenase | 1991 |
Vanadate inhibits agonist binding to D2 dopamine receptor.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Cell Membrane; Corpus Striatum; Dopamine Agents; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Kinetics; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Vanadates | 1991 |
Dopamine receptor antagonists block the effect of Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) on the opiate form of footshock-induced analgesia.
Topics: Amino Acid Sequence; Animals; Benzazepines; Dopamine Antagonists; Drug Synergism; Foot; Haloperidol; Hot Temperature; Male; Molecular Sequence Data; MSH Release-Inhibiting Hormone; Naloxone; Pain; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Transcutaneous Electric Nerve Stimulation | 1991 |
The effect of haloperidol, spiperone and dantrolene on the concentrations of creatine phosphate, ATP and lactate in brain and skeletal muscle of the rat during halothane anesthesia.
Topics: Adenosine Triphosphate; Anesthesia; Animals; Antipsychotic Agents; Brain Chemistry; Dantrolene; Female; Haloperidol; Halothane; Lactates; Lactic Acid; Muscles; Phosphocreatine; Rats; Rats, Inbred Strains; Spiperone | 1991 |
Behavioural and electoencephalographic interactions between haloperidol and PCP/sigma ligands in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Catalepsy; Electroencephalography; Haloperidol; Isoquinolines; Kinetics; Male; Phenazocine; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma; Spiperone | 1991 |
Effect of ferric nitrilotriacetate on rostral mesencephalic cells.
Topics: Animals; Cells, Cultured; Clonazepam; Dopamine; Ferric Compounds; Flunitrazepam; Glutamate-Ammonia Ligase; Haloperidol; Mesencephalon; Mice; Neuroglia; Neurons; Nitrilotriacetic Acid; Spiperone | 1991 |
Dopamine receptors labelled by [3H]quinpirole.
Topics: Animals; Corpus Striatum; Dogs; Dopamine Agents; Dopamine Antagonists; Ergolines; Guanine Nucleotides; Haloperidol; In Vitro Techniques; Quinpirole; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1991 |
Regulation and molecular characterization of dopamine D2 receptors in a prolactin-secreting 7315a anterior pituitary tumor.
Topics: Animals; Azides; Blotting, Northern; Butaclamol; Corpus Striatum; Female; Haloperidol; In Vitro Techniques; Kinetics; Neoplasms, Experimental; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactin; Rats; Rats, Inbred BUF; Receptors, Dopamine; RNA, Messenger; Spiperone | 1990 |
Effect of haloperidol on expression of dopamine D2 receptor mRNAs in rat brain.
Topics: Animals; Blotting, Northern; Brain; Gene Expression; Haloperidol; Nucleic Acid Hybridization; Poly A; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Reference Values; RNA; RNA, Messenger; Spiperone | 1990 |
Dopaminergic regulation of dopamine release from PC12 cells via a pertussis toxin-sensitive G protein.
Topics: Adrenal Gland Neoplasms; Animals; Apomorphine; Cell Line; Dopamine; Dopamine Antagonists; Ergolines; GTP-Binding Proteins; Haloperidol; Nicotine; Pertussis Toxin; Pheochromocytoma; Potassium; Quinpirole; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Virulence Factors, Bordetella | 1991 |
Permanent haloperidol-induced dopamine receptor up-regulation in the ovariectomized rat.
Topics: Animals; Apomorphine; Female; Haloperidol; Ovariectomy; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Reference Values; Spiperone; Stereotyped Behavior; Time Factors; Up-Regulation | 1991 |
Positron emission tomography with (18F)methylspiperone demonstrates D2 dopamine receptor binding differences of clozapine and haloperidol.
Topics: Adult; Aged; Brain Chemistry; Clozapine; Female; Fluorine Radioisotopes; Glucose; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed; Tomography, X-Ray Computed | 1991 |
In vitro and in vivo D2-dopamine receptor binding with [123I]S(-) iodobenzamide ([123I]IBZM) in rat and human brain.
Topics: Animals; Benzamides; Binding, Competitive; Brain; Corpus Striatum; Dopamine Antagonists; Female; Haloperidol; Humans; In Vitro Techniques; Iodine Radioisotopes; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine D2; Spiperone; Stereoisomerism | 1991 |
Selective dopamine antagonists reduce nicotine self-administration.
Topics: Animals; Benzazepines; Conditioning, Operant; Dopamine Antagonists; Food; Haloperidol; Male; Motor Activity; Nicotine; Rats; Reinforcement Schedule; Self Administration; Spiperone | 1991 |
Effects of acute and chronic systemic administration of some typical antipsychotic drugs on turnover of dopamine and potassium ion-induced release of dopamine in the striatum of the rat in vivo.
Topics: Animals; Biotransformation; Chlorpromazine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Male; Potassium; Rats; Rats, Inbred Strains; Spiperone | 1991 |
Effects of antipsychotic drugs on 5-HT2 receptors in the medial prefrontal cortex: microiontophoretic studies.
Topics: Amphetamines; Animals; Antipsychotic Agents; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Evoked Potentials; Frontal Lobe; Haloperidol; Iontophoresis; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone | 1990 |
Effects of dopaminergic agents on alcohol consumption by rats in a limited access paradigm.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Alcohol Drinking; Amphetamine; Animals; Benzazepines; Dopamine Agents; Dose-Response Relationship, Drug; Drinking Behavior; Ergolines; Haloperidol; Male; Quinpirole; Rats; Rats, Inbred Strains; Spiperone | 1990 |
[The inhibition of dopamine D1 and D2 receptors in human putamen by antipsychotic drugs].
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzamides; Benzazepines; Chlorpromazine; Depression, Chemical; Female; Haloperidol; Humans; In Vitro Techniques; Putamen; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Sulpiride | 1990 |
A pharmacological analysis of the eating response induced by 8-OH-DPAT injected into the dorsal raphé nucleus reveals the involvement of a dopaminergic mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dopamine; Drug Interactions; Eating; Haloperidol; Injections; Male; Metergoline; Naphthalenes; Propranolol; Raphe Nuclei; Rats; Rats, Inbred Strains; Spiperone; Tetrahydronaphthalenes | 1990 |
N-methyl-D-aspartate-induced neuronal activation is selectively modulated by sigma receptors.
Topics: Animals; Aspartic Acid; Guanidines; Haloperidol; In Vitro Techniques; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Spiperone | 1990 |
Clozapine fails to prevent the development of haloperidol-induced behavioral hypersensitivity in a cotreatment paradigm.
Topics: Animals; Apomorphine; Behavior, Animal; Binding, Competitive; Brain Chemistry; Clozapine; Corpus Striatum; Dopamine; Drug Interactions; Haloperidol; Male; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Thioridazine | 1990 |
Ethanol reduces tolerance, sensitization, and up-regulation of D2-receptors after subchronic haloperidol.
Topics: Animals; Apomorphine; Behavior, Animal; Body Weight; Dose-Response Relationship, Drug; Drug Tolerance; Ethanol; Female; Haloperidol; Kinetics; Postural Balance; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Up-Regulation | 1990 |
Biogenic amine binding sites in rabbit spermatozoa.
Topics: Animals; Binding Sites; Biogenic Amines; Epinephrine; Haloperidol; In Vitro Techniques; Male; Mianserin; Rabbits; Sperm Head; Sperm Tail; Spermatozoa; Spiperone | 1990 |
Preparation and characterization of antisera and monoclonal antibodies to haloperidol.
Topics: Animals; Antibodies, Monoclonal; Antibody Affinity; Cells, Cultured; Epitopes; Haloperidol; Immune Sera; Mice; Mice, Inbred BALB C; Rabbits; Radioimmunoassay; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1985 |
Binding of psychoactive drugs to rat brain amine receptors, measured ex vivo, and their effects on the metabolism of biogenic amines.
Topics: Animals; Biogenic Amines; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Prazosin; Psychotropic Drugs; Rats; Rats, Inbred Strains; Receptors, Drug; Spiperone | 1986 |
Differential modulation of dopamine D2 receptors by chronic haloperidol, nitrendipine, and pimozide.
Topics: Animals; Corpus Striatum; Haloperidol; Ion Channels; Male; Nitrendipine; Pimozide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1986 |
Dopamine antagonists reduce spontaneous electrical activity in cultured mammalian neurons from ventral mesencephalon.
Topics: Action Potentials; Animals; Apomorphine; Butaclamol; Cells, Cultured; Dibenzocycloheptenes; Dopamine Antagonists; Fetus; Haloperidol; Membrane Potentials; Mesencephalon; Mice; Mice, Inbred ICR; Neurons; Receptors, Dopamine; Spinal Cord; Spiperone | 1986 |
Kinetic modeling of receptor-ligand binding applied to positron emission tomographic studies with neuroleptic tracers.
Topics: Animals; Antipsychotic Agents; Benperidol; Butaclamol; Cerebellum; Corpus Striatum; Female; Fluorine; Haloperidol; Kinetics; Models, Biological; Papio; Radioisotopes; Receptors, Dopamine; Spiperone; Tomography, Emission-Computed | 1987 |
In vitro characterisation of dopamine receptors in the superior colliculus of the rat.
Topics: Animals; Apomorphine; Binding, Competitive; Butaclamol; Catecholamines; Corpus Striatum; Haloperidol; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin; Spiperone; Sulpiride; Superior Colliculi; Synaptosomes | 1987 |
Thermodynamic analysis of antagonist and agonist interactions with dopamine receptors.
Topics: Animals; Apomorphine; Butaclamol; Caudate Nucleus; Haloperidol; In Vitro Techniques; Microsomes; Receptors, Dopamine; Sheep; Spiperone; Temperature; Thermodynamics | 1988 |
Dopamine receptors on adrenal chromaffin cells modulate calcium uptake and catecholamine release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Glands; Animals; Apomorphine; Butaclamol; Calcium; Calcium Radioisotopes; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Electric Conductivity; Haloperidol; Ion Channels; Nicotine; Potassium; Receptors, Dopamine; Spiperone; Sulpiride | 1988 |
Immuno-photoaffinity labeling of the D2-dopamine receptor.
Topics: Affinity Labels; Animals; Apomorphine; Azides; Butaclamol; Cattle; Corpus Striatum; Haloperidol; Immunologic Techniques; Kinetics; Molecular Weight; Photochemistry; Receptors, Dopamine; Spiperone | 1988 |
Difference in catalepsy response in inbred rats during chronic haloperidol treatment is not predictive of the intensity of behavioral hypersensitivity which subsequently develops.
Topics: Animals; Behavior, Animal; Catalepsy; Corpus Striatum; Haloperidol; Male; Rats; Rats, Inbred F344; Receptors, Dopamine; Species Specificity; Spiperone; Stereotyped Behavior | 1989 |
Effects of chronic haloperidol on stress-induced oral behaviour in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Body Weight; Corpus Striatum; Feeding Behavior; Haloperidol; Male; Rats; Rats, Inbred Strains; Reaction Time; Spiperone; Stereotyped Behavior; Stress, Psychological | 1989 |
Effects of acute and chronic treatments with clozapine and haloperidol on serotonin (5-HT2) and dopamine (D2) receptors in the rat brain.
Topics: Animals; Autoradiography; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Image Processing, Computer-Assisted; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Septal Nuclei; Spiperone; Time Factors | 1989 |
Chronic neuroleptic treatment in rats produces persisting changes in GABAA and dopamine D-2, but not dopamine D-1 receptors.
Topics: Animals; Autoradiography; Behavior, Animal; Benzazepines; Brain; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Fluphenazine; Haloperidol; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, GABA-A; Spiperone | 1989 |
Rapid isolation with Sep-Pak C18 cartridges and wide-bore capillary gas chromatography of some butyrophenones.
Topics: Antipsychotic Agents; Butyrophenones; Chromatography, Gas; Haloperidol; Humans; Spiperone | 1989 |
Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia.
Topics: Adolescent; Adult; Cerebellum; Corpus Striatum; Dopamine Agents; Dopamine Antagonists; Fluorine Radioisotopes; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Schizophrenia; Spiperone; Tomography, Emission-Computed | 1989 |
Definition of the in-vivo binding of [3H]spiperone in rat brain using substituted benzamide drugs.
Topics: Amisulpride; Animals; Apomorphine; Benzamides; Binding, Competitive; Brain Chemistry; Female; Haloperidol; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Sulpiride | 1989 |
CI-943, a potential antipsychotic agent. II. Neurochemical effects.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain Chemistry; Clozapine; Dopamine; Haloperidol; Imidazoles; In Vitro Techniques; Male; Mice; Neurotransmitter Agents; Norepinephrine; Prolactin; Pyrimidines; Rats; Rats, Inbred Strains; Serotonin; Spiperone | 1989 |
Comparison of three 18F-labeled butyrophenone neuroleptic drugs in the baboon using positron emission tomography.
Topics: Animals; Benperidol; Brain; Butaclamol; Butyrophenones; Female; Fluorine; Haloperidol; Isotope Labeling; Male; Papio; Radioisotopes; Rats; Spiperone; Time Factors; Tissue Distribution; Tomography, Emission-Computed | 1985 |
Drug potencies on partially purified brain D2 dopamine receptors.
Topics: Animals; Butaclamol; Chlorpromazine; Corpus Striatum; Dogs; Fluphenazine; Haloperidol; Isoelectric Focusing; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Stereoisomerism; Time Factors | 1985 |
Striatal dopamine receptor supersensitivity after long-term haloperidol treatment of hypophysectomized rats.
Topics: Animals; Binding Sites; Corpus Striatum; Haloperidol; Hypophysectomy; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1989 |
The evidence for the involvement of the 5-HT1A receptor in 5-HT syndrome induced in mice by tryptamine.
Topics: Animals; Behavior, Animal; Haloperidol; Ketanserin; Male; Methysergide; Mice; Mice, Inbred DBA; Propranolol; Receptors, Serotonin; Serotonin; Spiperone; Tryptamines | 1989 |
Radioreceptor assay of dopamine binding activity in human serum after tiospirone administration.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Dopamine; Half-Life; Haloperidol; Humans; Male; Middle Aged; Protein Binding; Psychotropic Drugs; Radioligand Assay; Spiperone; Spiro Compounds | 1989 |
Partition coefficients of dopamine antagonists in brain membranes and liposomes.
Topics: Animals; Caudate Nucleus; Domperidone; Dopamine Antagonists; Haloperidol; Intracellular Membranes; Kinetics; Liposomes; Microsomes; Pimozide; Sheep; Spiperone; Thermodynamics | 1989 |
Effect of chronic administration of haloperidol (intermittently) and haloperidol-decanoate (continuously) on D2 dopamine and muscarinic cholinergic receptors and on carbachol-stimulated phosphoinositide hydrolysis in the rat striatum.
Topics: Animals; Binding Sites; Carbachol; Corpus Striatum; Haloperidol; Hippocampus; In Vitro Techniques; Norepinephrine; Phosphatidylinositols; Quinuclidinyl Benzilate; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Muscarinic; Spiperone | 1987 |
Different plasticity changes in D1 and D2 receptors in rat striatal subregions following impairment of dopaminergic transmission.
Topics: Animals; Benzazepines; Corpus Striatum; Dopamine; Haloperidol; Hydroxydopamines; Male; Neuronal Plasticity; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Synaptic Transmission | 1988 |
Sigma receptors in post-mortem human brains.
Topics: Adult; Animals; Brain Chemistry; Guinea Pigs; Haloperidol; Humans; Male; Middle Aged; Postmortem Changes; Receptors, Opioid; Receptors, sigma; Spiperone; Stereoisomerism | 1988 |
Syntheses and specific activity determinations of no-carrier-added (NCA) F-18-labeled butyrophenone neuroleptics--benperidol, haloperidol, spiroperidol, and pipamperone.
Topics: Antipsychotic Agents; Benperidol; Butyrophenones; Fluorine; Haloperidol; Isotope Labeling; Radioisotopes; Spiperone | 1985 |
[Effect of carbidine on the dopamine and serotonin receptors of the central nervous system].
Topics: Animals; Antipsychotic Agents; Brain; Carbolines; Central Nervous System; Haloperidol; Humans; Indoles; Male; Mice; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Spiperone; Stereotyped Behavior; Sulpiride | 1985 |
Sensitive analysis of butyrophenone neuroleptics by high-performance liquid chromatography with ultraviolet detection at 254 nm.
Topics: Animals; Antipsychotic Agents; Brain; Chromatography, High Pressure Liquid; Haloperidol; Male; Rats; Spectrophotometry, Ultraviolet; Spiperone; Trifluperidol | 1985 |
[The affinity of aromatic fluoride derivatives of phenothiazine neuroleptics to spiroperidol binding sites of dopamine receptors by the radioligand technic in vitro].
Topics: Animals; Antipsychotic Agents; Brain; Butyrophenones; Haloperidol; In Vitro Techniques; Male; Phenothiazines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1985 |
Comparative chronic effects of buspirone or neuroleptics on rat brain dopaminergic neurotransmission.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Body Weight; Buspirone; Dopamine; Female; Haloperidol; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Synaptic Transmission; Time Factors; Trifluoperazine; Tyrosine 3-Monooxygenase | 1985 |
Differential effect of subchronic treatment with various neuroleptic agents on serotonin2 receptors in rat cerebral cortex.
Topics: 5,7-Dihydroxytryptamine; Animals; Antipsychotic Agents; Cerebral Cortex; Chlorpromazine; Clozapine; Female; Haloperidol; Imipramine; Ketanserin; Loxapine; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone; Sulpiride | 1986 |
Zetidoline, a specific dopamine antagonist devoid of antiserotonergic activity in rodent brain.
Topics: 5-Hydroxytryptophan; Animals; Antipsychotic Agents; Binding, Competitive; Brain; Chlorpromazine; Dopamine Antagonists; Haloperidol; Imidazoles; In Vitro Techniques; Male; Mice; Rats; Rats, Inbred Strains; Reflex; Seizures; Serotonin; Serotonin Antagonists; Spiperone; Synaptic Membranes | 1985 |
Do antipsychotic drugs and serotonin down regulate [3H]-spiroperidol binding sites in human cortex?
Topics: Adolescent; Adult; Antipsychotic Agents; Binding Sites; Butyrophenones; Cerebral Cortex; Chlorpromazine; Haloperidol; Humans; Kinetics; Middle Aged; Prazosin; Serotonin; Spiperone | 1986 |
Radio receptor assay of serum neuroleptic levels in psychiatric patients.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Chlorpromazine; Dose-Response Relationship, Drug; Haloperidol; Humans; Radioligand Assay; Receptors, Dopamine; Schizophrenia; Spiperone | 1986 |
Neuroleptic drugs and 5HT1 receptor: different potencies of various neuroleptic drugs on 5HT1 receptors in discrete regions of the rat brain.
Topics: Animals; Antipsychotic Agents; Brain; Chlorpromazine; Dibenzothiepins; Haloperidol; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone | 1985 |
Typical and atypical antipsychotic occupancy of D2 and S2 receptors: an autoradiographic analysis in rat brain.
Topics: Animals; Antipsychotic Agents; Autoradiography; Binding, Competitive; Brain; Caudate Nucleus; Haloperidol; Ketanserin; Kinetics; Male; Nucleus Accumbens; Olfactory Bulb; Piperidines; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Spiperone | 1986 |
Effects of BMY 14802, a potential antipsychotic drug, on rat brain dopaminergic function.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Brain; Buspirone; Dopamine; Female; Haloperidol; Neurons; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Substantia Nigra; Tyrosine 3-Monooxygenase | 1986 |
Evaluation of 75Br-labelled butyrophenone neuroleptics for imaging cerebral dopaminergic receptor areas using positron emission tomography.
Topics: Animals; Antipsychotic Agents; Benperidol; Brain; Bromine; Cerebellum; Female; Haloperidol; Radioisotopes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Tomography, Emission-Computed | 1986 |
Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.
Topics: Adult; Antipsychotic Agents; Caudate Nucleus; Haloperidol; Humans; Kinetics; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed | 1986 |
Relationship between dopamine receptor occupation by spiperone and acetylcholine levels in the rat striatum after long-term haloperidol treatment depends on dopamine innervation.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Corpus Striatum; Dopamine; Haloperidol; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Time Factors | 1987 |
Effect of prolonged treatment with neuroleptics on dopamine D-1 and D-2 receptor density in corpus striatum of mice.
Topics: Animals; Antipsychotic Agents; Benzazepines; Clopenthixol; Corpus Striatum; Haloperidol; Male; Mice; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone | 1986 |
Toxicology of tremorgenic mycotoxins, fumitremorgin A and B.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Chlorpromazine; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Haloperidol; Harmine; Indenes; Indoles; Lethal Dose 50; Male; Mice; Perphenazine; Posture; Reserpine; Seizures; Spiperone; Triflupromazine | 1986 |
Differences in the time course of haloperidol-induced up-regulation of rat striatal and mesolimbic dopamine receptors.
Topics: Animals; Antipsychotic Agents; Corpus Striatum; Haloperidol; Limbic System; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1988 |
Differential alteration in striatal dopaminergic and cortical serotonergic receptors induced by repeated administration of haloperidol or centbutindole in rats.
Topics: 5-Hydroxytryptophan; Animals; Antipsychotic Agents; Apomorphine; Cerebral Cortex; Corpus Striatum; Haloperidol; Male; Pyrazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Spiperone; Stereotyped Behavior | 1988 |
Definition of the in-vivo accumulation of [3H]spiperone in brain using haloperidol and sulpiride to determine functional dopamine receptor occupation.
Topics: Animals; Apomorphine; Brain Chemistry; Corpus Striatum; Female; Haloperidol; Homovanillic Acid; Limbic System; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1988 |
Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity.
Topics: Amphetamines; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; DOM 2,5-Dimethoxy-4-Methylamphetamine; Electric Stimulation; Evoked Potentials; Haloperidol; Locus Coeruleus; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Serotonin; Sciatic Nerve; Spiperone; Sulpiride | 1988 |
Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat.
Topics: Animals; Apomorphine; Behavior, Animal; Betaxolol; Haloperidol; Ketanserin; Male; Pindolol; Piperidines; Prazosin; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reserpine; Spiperone | 1985 |
Quantification of Neuroreceptors in the living human brain. II. Inhibition studies of receptor density and affinity.
Topics: Adolescent; Adult; Brain; Caudate Nucleus; Haloperidol; Humans; Kinetics; Ligands; Male; Middle Aged; Models, Biological; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D2; Sensory Receptor Cells; Spiperone; Tomography, Emission-Computed | 1986 |
Comparison of motor depressant effects of caerulein and N-propylnorapomorphine in mice.
Topics: 5,7-Dihydroxytryptamine; Animals; Apomorphine; Ceruletide; Depression, Chemical; Exploratory Behavior; Fenclonine; Haloperidol; Hydroxydopamines; Male; Mice; Motor Activity; Nerve Endings; Oxidopamine; Receptors, Dopamine; Receptors, Serotonin; Sincalide; Spiperone | 1986 |
Reserpine-induced up-regulation of dopamine D2 receptors in the rat striatum is enhanced by denervation but not by chronic receptor blockade.
Topics: Animals; Corpus Striatum; Denervation; Dopamine; Haloperidol; Male; Neurons; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Reserpine; Spiperone | 1986 |
Differential recovery rates of rat D2 dopamine receptors as a function of aging and chronic reserpine treatment following irreversible modification: a key to receptor regulatory mechanisms.
Topics: Aging; Animals; Apomorphine; Corpus Striatum; Guanylyl Imidodiphosphate; Haloperidol; In Vitro Techniques; Kinetics; Male; Quinolines; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Dopamine; Receptors, Dopamine D2; Reserpine; Spiperone | 1987 |
Reconstitution of affinity-purified dopamine D2 receptor binding activities by specific lipids.
Topics: Animals; Binding, Competitive; Cattle; Chromatography, Affinity; Corpus Striatum; Haloperidol; Kinetics; Liposomes; Phospholipids; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1987 |
Dopamine D2 receptors in the striatum and frontal cortex following chronic administration of haloperidol.
Topics: Animals; Corpus Striatum; Frontal Lobe; Haloperidol; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Time Factors | 1987 |
[3H]spiroxatrine labels a serotonin1A-like site in the rat hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Cell Membrane; Dioxanes; Dioxins; Dopamine; Guanosine Triphosphate; Haloperidol; Hippocampus; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone; Spiro Compounds; Tetrahydronaphthalenes; Tritium | 1987 |
Excitatory and inhibitory action of dopamine on hippocampal neurons in vitro. Involvement of D2 and D1 receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Culture Techniques; Dopamine; Dopamine Antagonists; Haloperidol; Hippocampus; Male; Neurons; Pergolide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Sulpiride | 1987 |
Chronic haloperidol affects striatal D2-dopamine receptor reappearance after irreversible receptor blockade.
Topics: Animals; Corpus Striatum; Haloperidol; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1987 |
Serial [18F]N-methylspiroperidol PET studies to measure changes in antipsychotic drug D-2 receptor occupancy in schizophrenic patients.
Topics: Adult; Binding, Competitive; Chlorpromazine; Corpus Striatum; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed | 1988 |
Purification of the D-2 dopamine receptor from bovine striatum.
Topics: Animals; Cattle; Cell Membrane; Chromatography, Affinity; Chromatography, Gel; Corpus Striatum; Dopamine; Haloperidol; Kinetics; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1988 |
Influence of GABA mimetics and lithium on biochemical manifestations of striatal dopamine target cell hypersensitivity.
Topics: Animals; Corpus Striatum; gamma-Aminobutyric Acid; Haloperidol; Kinetics; Lithium; Rats; Receptors, Dopamine; Spiperone; Synapses; Synaptic Transmission | 1985 |
Consequences of perinatal drug administration on brain development: striatal opiate receptors and dopamine.
Topics: Animals; Autoradiography; Brain; Caudate Nucleus; Corpus Striatum; Female; Haloperidol; Nucleus Accumbens; Pregnancy; Putamen; Receptors, Dopamine; Receptors, GABA-A; Receptors, Opioid; Spiperone | 1985 |
Studies on the use of a novel affinity matrix, sepharose amine-succinyl-amine haloperidol hemisuccinate, ASA-HHS, for purification of canine dopamine (D2) receptor.
Topics: Animals; Charcoal; Chromatography, Affinity; Corpus Striatum; Dogs; Electrophoresis, Polyacrylamide Gel; Haloperidol; In Vitro Techniques; Molecular Weight; Receptors, Adrenergic, beta; Receptors, Dopamine; Receptors, Dopamine D2; Solubility; Spiperone; Tritium | 1986 |
Effects of intermittent and continuous haloperidol administration on the dopaminergic system in the rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Drug Administration Schedule; Haloperidol; Homovanillic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Synaptic Transmission | 1986 |
Autoradiographic distribution of non-dopaminergic binding sites labeled by [3H]haloperidol in rat brain.
Topics: Animals; Autoradiography; Benzazepines; Binding, Competitive; Brain; Haloperidol; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Spiperone; Sulpiride | 1987 |
Hypothyroidism leads to increased dopamine receptor sensitivity and concentration.
Topics: Animals; Apomorphine; Body Temperature; Conditioning, Operant; Haloperidol; Hypothyroidism; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Thyroid Hormones; Thyrotropin-Releasing Hormone; Tritium | 1986 |
Dopaminergic inhibition of tyrosinase activity in hair follicular melanocytes of the mouse.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Bromocriptine; Catechol Oxidase; Depression, Chemical; Dopamine; Ergolines; Female; Hair; Haloperidol; Male; Melanocytes; Mice; Mice, Inbred C3H; Monophenol Monooxygenase; Quinpirole; Skin; Spiperone; Sulpiride | 1986 |
Differential effects of proglumide on mesolimbic and nigrostriatal dopamine function.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Glutamine; Haloperidol; Kainic Acid; Kinetics; Limbic System; Male; Proglumide; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra | 1987 |
Behavioral and neurochemical responses to haloperidol and SCH-23390 in rats treated neonatally or as adults with 6-hydroxydopamine.
Topics: Age Factors; Animals; Animals, Newborn; Benzazepines; Biogenic Amines; Brain Chemistry; Dopamine Antagonists; Female; Haloperidol; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1987 |
Chronic haloperidol administration increases the density of D2 dopamine receptors in the medial prefrontal cortex of the rat.
Topics: Animals; Cerebral Cortex; Haloperidol; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1988 |
Dopamine receptors in the developing sheep kidney.
Topics: Animals; Animals, Newborn; Benzazepines; Binding Sites; Binding, Competitive; Dopamine Antagonists; Female; Fetus; Haloperidol; Kidney; Kinetics; Pregnancy; Receptors, Dopamine; Sheep; Spiperone | 1988 |
Chronic haloperidol does not alter agonist affinity for dopamine receptors in vitro.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Haloperidol; Indoles; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1985 |
Differential alteration of striatal D-1 and D-2 receptors induced by the long-term administration of haloperidol, sulpiride or clozapine to rats.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Dose-Response Relationship, Drug; Haloperidol; Humans; Kinetics; Long-Term Care; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior; Sulpiride; Thioxanthenes | 1985 |
Changes of the striatal 3H-spiperone binding 3-6 weeks after nigrostriatal denervation and after two years.
Topics: Animals; Butyrophenones; Corpus Striatum; Denervation; Haloperidol; Hydroxydopamines; Ketanserin; Kinetics; Male; Oxidopamine; Piperidines; Rats; Rats, Inbred Strains; Spiperone; Substantia Nigra; Time Factors | 1985 |
Repeated administration of HA-966 and haloperidol to rats: similar tolerance to striatal dopamine accumulation after HA-966 challenge, but dissimilar effects on striatal [3H]spiperone binding.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Drug Tolerance; Haloperidol; Homovanillic Acid; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1988 |
Quinpirole hydrochloride, a potential anti-parkinsonism drug.
Topics: Animals; Benzazepines; Corpus Striatum; Dogs; Dose-Response Relationship, Drug; Ergolines; Grooming; Haloperidol; Male; Motor Activity; Parkinson Disease; Quinpirole; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Sulpiride | 1987 |
A dietary haloperidol regimen for inducing dopamine receptor supersensitivity in rats.
Topics: Administration, Oral; Animals; Apomorphine; Brain; Drug Resistance; Haloperidol; Injections, Subcutaneous; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1987 |
Ascorbic acid reduces accumulation of [3H]spiperone in mouse striatum in vivo.
Topics: Animals; Apomorphine; Ascorbic Acid; Cerebellum; Corpus Striatum; Depression, Chemical; Dopamine Antagonists; Drug Synergism; Haloperidol; Mice; Receptors, Dopamine; Spiperone | 1987 |
The effect of ethanol and haloperidol on dopamine receptor (D2) density.
Topics: Animals; Corpus Striatum; Ethanol; Female; Haloperidol; Membranes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1987 |
Failure to detect dopamine receptor IgG autoantibodies in sera of schizophrenic patients. Short note.
Topics: Autoantibodies; Binding, Competitive; Haloperidol; Humans; Immunoglobulin G; Receptors, Dopamine; Schizophrenia; Spiperone | 1987 |
Effect of long-term dosing with tiapride on brain dopamine receptors and metabolism in rats. Comparative study with sulpiride and haloperidol.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Apomorphine; Benzamides; Brain Chemistry; Dopamine; Haloperidol; Homovanillic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Sulpiride; Tiapamil Hydrochloride | 1987 |
Motor effects of calcitonin administered intracerebroventricularly in the rat.
Topics: Animals; Behavior, Animal; Calcitonin; Cerebral Ventricles; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; Haloperidol; Male; Motor Activity; Radioligand Assay; Rats; Rats, Inbred Strains; Spiperone; Time Factors | 1986 |
Characterization of a dopaminergic receptor that modulates adrenomedullary catecholamine release.
Topics: Adrenal Medulla; Animals; Apomorphine; Binding, Competitive; Catecholamines; Cattle; Cell Membrane; Haloperidol; Kinetics; Nicotine; Rats; Receptors, Dopamine; Spiperone | 1986 |
Role of assay conditions in determining agonist potency at D2 dopamine receptors in striatal homogenates.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dopamine; Guanosine Triphosphate; Haloperidol; Kinetics; Magnesium; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1986 |
Effect of lead exposure on dopaminergic receptors in rat striatum and nucleus accumbens.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Corpus Striatum; Female; Haloperidol; Lead Poisoning; Male; Nucleus Accumbens; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Dopamine; Septal Nuclei; Spiperone; Sulpiride | 1986 |
Characterization of high-affinity dopamine D2 receptors and modulation of affinity states by guanine nucleotides in cholate-solubilized bovine striatal preparations.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Cholic Acid; Cholic Acids; Computers; Corpus Striatum; Domperidone; Guanine Nucleotides; Guanylyl Imidodiphosphate; Haloperidol; Kinetics; Receptors, Dopamine; Solubility; Spiperone | 1986 |
Hyperprolactinaemia does not alter specific striatal 3H-spiperone binding in the rat.
Topics: Animals; Corpus Striatum; Dopamine; Haloperidol; In Vitro Techniques; Male; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Sulpiride; Tritium | 1986 |
Hypophysectomy may non-selectively alter pharmacokinetic parameters to enhance the ability of haloperidol to increase striatal dopamine receptor density in the rat.
Topics: Animals; Binding Sites; Corpus Striatum; Haloperidol; Hypophysectomy; Kinetics; Male; Motor Activity; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1986 |
Pharmacologic evaluation of dopaminergic receptor blockade by metoclopramide.
Topics: Animals; Behavior, Animal; Catalepsy; Dopamine; Haloperidol; Male; Metoclopramide; Motor Activity; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1986 |
In vivo quantitative imaging of dopamine receptors in human brain using positron emission tomography and [76Br]bromospiperone.
Topics: Adult; Aged; Biological Transport, Active; Brain; Butyrophenones; Cerebellum; Cerebral Cortex; Corpus Striatum; Female; Haloperidol; Humans; Kinetics; Male; Middle Aged; Receptors, Dopamine; Schizophrenia; Spiperone; Tissue Distribution; Tomography, Emission-Computed | 1985 |
Effects of a fluorinated pyrimidinedione anti-cancer drug, 5-fluoro-1-(tetrahydro-2-furanyl)-2,4-pyrimidinedione (FT), and related compounds on nigro-striatal dopaminergic neurons in the central nervous system.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Antineoplastic Agents; Corpus Striatum; Dopamine; Fluorouracil; Haloperidol; Homovanillic Acid; Male; Methyltyrosines; Motor Activity; Neurons; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Substantia Nigra; Tegafur; Time Factors; Uracil | 1985 |
Potential neuroleptic agents. 4. Chemistry, behavioral pharmacology, and inhibition of [3H]spiperone binding of 3,5-disubstituted N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamides.
Topics: Animals; Apomorphine; Chemical Phenomena; Chemistry; Corpus Striatum; Haloperidol; Male; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Salicylamides; Spiperone; Stereotyped Behavior; Structure-Activity Relationship | 1986 |
Regional sensitivity of neuroleptic receptors to sub-acute soman intoxication.
Topics: Animals; Binding, Competitive; Brain; Cerebral Cortex; Corpus Striatum; Haloperidol; Hippocampus; Kinetics; Male; Mianserin; Organophosphorus Compounds; Rats; Receptors, Dopamine; Soman; Spiperone | 1985 |
The electrical properties of isolated human prolactin-secreting adenoma cells and their modification by dopamine.
Topics: Adenoma; Bromocriptine; Domperidone; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; Flupenthixol; Haloperidol; Humans; In Vitro Techniques; Membrane Potentials; Phenethylamines; Pituitary Neoplasms; Prolactin; Receptors, Dopamine; Spiperone; Time Factors | 1985 |
Effects of phospholipids on the specific binding of [3H]spiroperidol to the cholate extract of rat brain synaptic membranes.
Topics: Animals; Apomorphine; Brain; Butyrophenones; Cerebellum; Cerebral Cortex; Cholic Acid; Cholic Acids; Corpus Striatum; Detergents; Dopamine; Haloperidol; In Vitro Techniques; Kinetics; Male; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines; Phospholipids; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Synaptic Membranes; Temperature | 1985 |
Failure of chronic haloperidol to affect prolactin secretion due to acute haloperidol administration.
Topics: Animals; Body Weight; Corpus Striatum; Haloperidol; Kinetics; Male; Pituitary Gland; Prolactin; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Time Factors | 1985 |
Effect of duration of haloperidol treatment on DA receptor supersensitization in aging C57BL/6J mice.
Topics: Age Factors; Animals; Apomorphine; Choline O-Acetyltransferase; Corpus Striatum; Haloperidol; Humans; Mice; Mice, Inbred C57BL; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1985 |
Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat.
Topics: Acetylcholine; Animals; Apomorphine; Body Weight; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Male; Mastication; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Thioxanthenes; Tritium | 1985 |
In vivo stereospecific [3H]spiperone binding in rat brain: characteristics, regional distribution, kinetics and pharmacological properties.
Topics: Animals; Binding Sites; Brain; Butyrophenones; Freezing; Haloperidol; Kinetics; Male; Rats; Rats, Inbred Strains; Spiperone; Stereoisomerism | 1985 |
Simultaneous catalepsy and apomorphine-induced stereotypic behavior in mice.
Topics: Animals; Apomorphine; Catalepsy; Chlorpromazine; Domperidone; Drug Interactions; Haloperidol; Injections, Intraventricular; Mice; Spiperone; Stereotyped Behavior; Sulpiride | 1985 |
Differential effects of haloperidol decanoate, a long-acting neuroleptic, in behavioral and biochemical tests.
Topics: Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Biogenic Amines; Brain Chemistry; Corpus Striatum; Female; Haloperidol; Injections, Intramuscular; Injections, Intraventricular; Male; Mice; Prolactin; Rats; Rats, Inbred Strains; Spiperone; Time Factors | 1985 |
The effect of dopamine receptor agonist treatment on haloperidol-induced supersensitivity in mice.
Topics: alpha-Methyltyrosine; Animals; Apomorphine; Corpus Striatum; Dextroamphetamine; Haloperidol; Levodopa; Male; Methyltyrosines; Mice; Motor Activity; Receptors, Dopamine; Reserpine; Spiperone | 1985 |
Possible dissociation of central dopamine receptor antagonism and cataleptic behavior.
Topics: Animals; Apomorphine; Catalepsy; Haloperidol; Male; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1985 |
Isolation and characterization of D2-dopamine receptors.
Topics: Animals; Binding Sites; Cattle; Caudate Nucleus; Haloperidol; Lysophosphatidylcholines; Receptors, Dopamine; Solubility; Spiperone | 1985 |
Effect of neurotensin, substance P and TRH on the regulation of dopamine receptors in rat brain.
Topics: Animals; Brain; Haloperidol; In Vitro Techniques; Male; Neurotensin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Substance P; Thyrotropin-Releasing Hormone | 1984 |
Prenatal haloperidol alters striatal dopamine and opiate receptors.
Topics: Animals; Corpus Striatum; Female; Haloperidol; Maternal-Fetal Exchange; Naloxone; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Spiperone | 1984 |
Elevation of brain neuroleptic/dopamine receptors in schizophrenia.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Brain; Butyrophenones; Caudate Nucleus; Haloperidol; Humans; Middle Aged; Nucleus Accumbens; Putamen; Receptors, Dopamine; Schizophrenia; Spiperone | 1980 |
Abnormal neuroleptic/dopamine receptors in schizophrenia.
Topics: Adult; Aged; Antipsychotic Agents; Apomorphine; Brain; Caudate Nucleus; Haloperidol; Humans; Middle Aged; Nucleus Accumbens; Receptors, Dopamine; Schizophrenia; Spiperone | 1980 |
Studies of the neural mechanisms by which hypothyroidism decreases prolactin secretion in the rat.
Topics: Animals; Caudate Nucleus; Dopamine; Haloperidol; Hypothalamo-Hypophyseal System; Hypothyroidism; Male; Median Eminence; Norepinephrine; Pituitary Gland; Prolactin; Rats; Spiperone; Thyroid Hormones; Tyrosine 3-Monooxygenase | 1980 |
Alterations in dopamine receptors: effect of lesion and haloperidol treatment.
Topics: Animals; Apomorphine; Corpus Striatum; Haloperidol; Hydroxydopamines; Limbic System; Male; Rats; Receptors, Dopamine; Spiperone; Substantia Nigra; Tyrosine 3-Monooxygenase | 1980 |
Dopamine-sensitive adenylate cyclase and dopamine/neuroleptic receptor binding: effect of neuroleptic drugs.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Dopamine; Haloperidol; Humans; Male; Motor Activity; Rats; Receptors, Dopamine; Receptors, Drug; Spiperone; Stereotyped Behavior | 1980 |
Interaction of oxypertine with rat brain monoamine receptors.
Topics: Adenylyl Cyclases; Animals; Biogenic Amines; Cerebral Cortex; Chlorpromazine; Corpus Striatum; Dopamine; Haloperidol; In Vitro Techniques; Indoles; Male; Piperazines; Rats; Receptors, Neurotransmitter; Spiperone | 1980 |
Dopamine receptors, neuroleptics, and schizophrenia.
Topics: Adenylyl Cyclases; Antipsychotic Agents; Apomorphine; Brain; Brain Chemistry; Caudate Nucleus; Dopamine; Guanosine Triphosphate; Haloperidol; Humans; Nucleus Accumbens; Radioligand Assay; Receptors, Dopamine; Schizophrenia; Spiperone | 1981 |
A radioreceptor assay for neuroleptic drugs in plasma.
Topics: Animals; Antipsychotic Agents; Binding Sites; Cattle; Chromatography, Gas; Dose-Response Relationship, Drug; Haloperidol; Heparin; Humans; Quality Control; Radioligand Assay; Receptors, Dopamine; Spiperone; Thioridazine | 1980 |
Effect of L-prolyl-L-leucyl-glycinamide (PLG) on neuroleptic-induced catalepsy and dopamine/neuroleptic receptor bindings.
Topics: Animals; Apomorphine; Catalepsy; Dose-Response Relationship, Drug; Haloperidol; Humans; Kinetics; Male; MSH Release-Inhibiting Hormone; Rats; Receptors, Dopamine; Receptors, Opioid; Spiperone | 1981 |
Differential sensitivity to neuroleptic drugs of cerebral dopamine receptors following chronic treatment of rats with trifluoperazine.
Topics: Animals; Antipsychotic Agents; Brain; Catalepsy; Female; Haloperidol; Humans; Radioligand Assay; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Tetrahydronaphthalenes; Trifluoperazine | 1981 |
Effects of chronic haloperidol, thioridazine and zotepine treatment on apomorphine elicited stereotypic behavior and 3H-spiroperidol binding sites in the striatum of the rat.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Butyrophenones; Corpus Striatum; Dibenzothiepins; Haloperidol; Humans; Male; Rats; Spiperone; Stereotyped Behavior; Thioridazine | 1981 |
Elevation of serum corticosterone concentrations in rats by pergolide and other dopamine agonists.
Topics: Animals; Antiparkinson Agents; Corticosterone; Domperidone; Dopamine Antagonists; Dose-Response Relationship, Drug; Ergolines; Haloperidol; Male; Metergoline; Mianserin; Pergolide; Rats; Rats, Inbred Strains; Spiperone | 1981 |
Neuroleptic drug-induced dopamine receptor supersensitivity: antagonism by L-prolyl-L-leucyl-glycinamide.
Topics: Animals; Butyrophenones; Chlorpromazine; Corpus Striatum; Haloperidol; Kinetics; Male; MSH Release-Inhibiting Hormone; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1981 |
Hypophysectomy does not prevent development of striatal dopamine receptor supersensitivity induced by repeated neuroleptic treatment.
Topics: Animals; Antipsychotic Agents; Corpus Striatum; Drug Resistance; Haloperidol; Humans; Hypophysectomy; Luteinizing Hormone; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1981 |
Chronic treatments with zotepine, thioridazine, and haloperidol affect apomorphine-elicited stereotypic behavior and striatal 3H-spiroperidol binding sites in the rat.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Butyrophenones; Corpus Striatum; Dibenzothiepins; Drug Interactions; Haloperidol; Humans; Male; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Thioridazine | 1981 |
Depletion of epinephrine in rat hypothalamus by a dopamine agonist, pergolide.
Topics: Animals; Antiparkinson Agents; Dopamine Antagonists; Epinephrine; Ergolines; Haloperidol; Hypothalamus; Kinetics; Male; Pergolide; Rats; Rats, Inbred Strains; Spiperone | 1982 |
Rat brain monoamine oxidase activity is not affected by repeated administration of haloperidol.
Topics: Animals; Brain; Corpus Striatum; Dopamine; Haloperidol; Male; Monoamine Oxidase; Rats; Rats, Inbred Strains; Spiperone | 1982 |
[Antipsychotics and kindling].
Topics: Amygdala; Animals; Antipsychotic Agents; Cats; Haloperidol; Kindling, Neurologic; Pimozide; Rats; Spiperone | 1982 |
Modulation of dopaminergic transmission by alpha-noradrenergic agonists and antagonists: evidence for antidopaminergic properties of some alpha antagonists.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Clonidine; Dopamine; Female; Haloperidol; Homovanillic Acid; Male; Prazosin; Rats; Spiperone; Synaptic Transmission; Yohimbine | 1982 |
Are dopamine receptors present on human lymphocytes?
Topics: Binding, Competitive; Cell Membrane; Haloperidol; Humans; Iodoacetates; Iodoacetic Acid; Lymphocytes; Receptors, Dopamine; Spiperone; Stereoisomerism | 1982 |
Decreased disrupting effect of neuroleptics on conditioned avoidance in rats with lesions in the mid-brain raphe nuclei.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Brain Stem; Chlorpromazine; Conditioning, Classical; Haloperidol; Male; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Spiperone | 1982 |
Aminoalkylindoles: atypical dopamine antagonists.
Topics: Amphetamine; Animals; Antipsychotic Agents; Catalepsy; Corpus Striatum; Dopamine Antagonists; Haloperidol; Humans; Indoles; Male; Mice; Prolactin; Rats; Rats, Inbred Strains; Spiperone | 1983 |
Biochemical and pharmacological differentiation of neuroleptic effect on dopamine D-1 and D-2 receptors.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Flupenthixol; Haloperidol; Rats; Receptors, Dopamine; Spiperone; Thioxanthenes | 1983 |
Long-term adaptive changes in striatal dopamine function in response to chronic neuroleptic intake in rats.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Apomorphine; Corpus Striatum; Glutamates; Glutamic Acid; Haloperidol; Rats; Receptors, Dopamine; Spiperone; Sulpiride | 1983 |
Changes in apomorphine-induced stereotypy as a result of subacute neuroleptic treatment correlates with increased D-2 receptors, but not with increases in D-1 receptors.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain; Drug Synergism; Flupenthixol; Haloperidol; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior; Sulpiride; Thioxanthenes | 1983 |
Neuroleptics have identical potencies in human brain limbic and putamen regions.
Topics: Antipsychotic Agents; Binding, Competitive; Haloperidol; Humans; In Vitro Techniques; Limbic System; Nucleus Accumbens; Putamen; Receptors, Dopamine; Spiperone; Thioridazine | 1983 |
Modulation of CNS dopamine receptors by peptides.
Topics: Animals; Behavior, Animal; Brain; Cholecystokinin; Corpus Striatum; Haloperidol; Limbic System; Male; Mesencephalon; Motor Activity; MSH Release-Inhibiting Hormone; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Cholecystokinin; Receptors, Dopamine; Spiperone; Synaptic Transmission | 1983 |
Enhanced striatal 3H-spiroperidol binding induced by chronic haloperidol treatment inhibited by peptides administered during the withdrawal phase.
Topics: Animals; Apomorphine; Butyrophenones; Corpus Striatum; Dipeptides; Haloperidol; Male; Motor Activity; MSH Release-Inhibiting Hormone; Neuropeptides; Peptides, Cyclic; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Time Factors | 1984 |
Electroconvulsive shock and neurotransmitter receptors: implications for mechanism of action and adverse effects of electroconvulsive therapy.
Topics: Animals; Brain; Dihydroalprenolol; Electroconvulsive Therapy; Haloperidol; Male; Neurotransmitter Agents; Norepinephrine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, beta; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Muscarinic; Receptors, Neurotransmitter; Spiperone; Synaptic Transmission | 1984 |
Imaging CNS receptors: the dopaminergic system.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Brain; Carbon Radioisotopes; Deoxyglucose; Dyskinesia, Drug-Induced; Fluorine; Haloperidol; Humans; Parkinson Disease; Radioisotopes; Receptors, Dopamine; Schizophrenia; Spiperone; Tomography, Emission-Computed; Tritium | 1984 |
Effects of prolyl-leucyl-glycinamide and cyclo(leucyl-glycine) on the supersensitivity of dopamine receptors in brain induced by chronic administration of haloperidol to rats.
Topics: Animals; Apomorphine; Body Weight; Cell Membrane; Corpus Striatum; Dipeptides; Haloperidol; In Vitro Techniques; Male; Motor Activity; MSH Release-Inhibiting Hormone; Neuropeptides; Peptides, Cyclic; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1984 |
Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Brain; Cell Membrane; Corpus Striatum; Guinea Pigs; Haloperidol; Kinetics; Male; Narcotics; Phenazocine; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Spiperone | 1984 |
Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzamides; Binding, Competitive; Brain Chemistry; Catalepsy; Chlorpromazine; Dogs; Female; Haloperidol; Histocytochemistry; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Remoxipride; Spiperone; Sulpiride; Thioridazine; Vomiting | 1984 |
Neuroleptic-induced striatal dopamine receptor supersensitivity in mice: relationship to dose and drug.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Corpus Striatum; Haloperidol; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Receptors, Dopamine; Spiperone | 1984 |
Antipsychotic drug effects on dopamine and serotonin receptors: in vitro binding and in vivo turnover studies.
Topics: Animals; Antipsychotic Agents; Brain; Butaclamol; Catalepsy; Dopamine; Fluphenazine; Haloperidol; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Spiperone | 1981 |
Characterization of catecholamine binding sites in the rat brain.
Topics: Animals; Brain; Butaclamol; Catecholamines; Corpus Striatum; Dihydroalprenolol; Dihydroergotoxine; Haloperidol; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Spiperone | 1981 |
Interaction of opiates with dopamine receptors: receptor binding and behavioral assays.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butaclamol; Dibenzocycloheptenes; Haloperidol; Kinetics; Male; Methadone; Morphine; Naloxone; Rats; Receptors, Dopamine; Spiperone | 1982 |
The effects of denervation and chronic haloperidol treatment on neostriatal dopamine receptor density are not additive in the rat.
Topics: Animals; Apomorphine; Butaclamol; Corpus Striatum; Drug Interactions; Haloperidol; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation; Spiperone | 1984 |
[3H]spiperone binding in the nigrostriatal system in human brain.
Topics: Aged; Apomorphine; Binding, Competitive; Butaclamol; Butyrophenones; Caudate Nucleus; Cinanserin; Corpus Striatum; Domperidone; Female; Haloperidol; Humans; In Vitro Techniques; Kinetics; Male; Nerve Endings; Phentolamine; Postmortem Changes; Putamen; Spiperone; Substantia Nigra; Sulpiride; Time Factors | 1984 |
Reduced haloperidol: effects on striatal dopamine metabolism and conversion to haloperidol in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Binding, Competitive; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; Liver; Male; Membranes; Rats; Rats, Inbred Strains; Serotonin; Spiperone | 1984 |
High- and low-affinity states of striatal D2 receptors are not affected by 6-hydroxydopamine or chronic haloperidol treatment.
Topics: Animals; Apomorphine; Butaclamol; Cinanserin; Corpus Striatum; Dopamine; Guanylyl Imidodiphosphate; Haloperidol; Hydroxydopamines; Male; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1984 |
Molindone compared to haloperidol in a guinea-pig model of tardive dyskinesia.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Guinea Pigs; Haloperidol; Humans; Indoles; Male; Molindone; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior | 1984 |
Chronic lithium administration has no effect on haloperidol-induced supersensitivity of pre- and postsynaptic dopamine receptors in rat brain.
Topics: Animals; Brain; Haloperidol; Limbic System; Lithium; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter; Spiperone; Substantia Nigra; Time Factors | 1982 |
Chronic rubidium does not prevent dopamine receptor supersensitivity.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Dihydroalprenolol; Haloperidol; Mice; Mice, Inbred C3H; Muridae; Receptors, Adrenergic, beta; Receptors, Dopamine; Rubidium; Spiperone | 1982 |
Effects of ethanol, given during pregnancy, on the offspring dopaminergic system.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dextroamphetamine; Dopamine; Ethanol; Female; Haloperidol; Kinetics; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Spiperone; Sulpiride; Synaptic Transmission | 1983 |
Effects of chronic lithium treatment on dopamine receptors in the rat corpus striatum. I. Locomotor activity and behavioral supersensitivity.
Topics: Animals; Apomorphine; Body Weight; Chlorides; Corpus Striatum; Eating; Haloperidol; Humans; Lithium; Lithium Chloride; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Effects of chronic lithium treatment on dopamine receptors in the rat corpus striatum. II. No effect on denervation or neuroleptic-induced supersensitivity.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Chlorides; Corpus Striatum; Dopamine; Haloperidol; Humans; Hydroxydopamines; Kinetics; Lithium; Lithium Chloride; Male; Motor Activity; Neural Pathways; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra | 1982 |
Autoradiographic mapping of spirodecanone binding-sites in the hippocampal region of the rat. Evidence for a localization on intrinsic neurons.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Mapping; Butyrophenones; Haloperidol; Hippocampus; Ketanserin; Male; Mianserin; Piperidines; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Dopamine; Serotonin; Spiperone; Tetrahydronaphthalenes | 1984 |
The relation between spiperone binding, behavioural changes, and in vivo tyrosine hydroxylation in the rat striatum.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Binding Sites; Catalepsy; Corpus Striatum; Dihydroxyphenylalanine; Haloperidol; Humans; Hydroxylation; Lysergic Acid Diethylamide; Male; Rats; Rats, Inbred Strains; Spiperone; Tyrosine | 1983 |
Modification of the behavioural effects of haloperidol and of dopamine receptor regulation by altered thyroid status.
Topics: Animals; Behavior, Animal; Body Temperature; Catalepsy; Haloperidol; Humans; Hyperthyroidism; Hypothyroidism; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Thyroid Hormones | 1984 |
The effects of chronic lithium on behavioral and biochemical indices of dopamine receptor supersensitivity in the rat.
Topics: Animals; Apomorphine; Behavior, Animal; Binding, Competitive; Body Temperature; Dextroamphetamine; Drug Interactions; Haloperidol; Humans; Lithium; Male; Motor Activity; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1984 |
Electroconvulsive treatment and haloperidol: effects on pre- and postsynaptic dopamine receptors in rat brain.
Topics: Animals; Brain; Dopamine; Electroconvulsive Therapy; Haloperidol; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1984 |
Effect of dopamine system activation on substantia nigra pars reticulata output neurons: variable single-unit responses in normal rats and inhibition in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Apomorphine; Dopamine; Efferent Pathways; Flupenthixol; Haloperidol; Hydroxydopamines; Injections, Intravenous; Male; Neural Inhibition; Neurons; Oxidopamine; Rats; Rats, Inbred Strains; Spiperone; Substantia Nigra; Tectum Mesencephali; Thalamus | 1984 |
Differential effects of continuous administration for 1 year of haloperidol or sulpiride on striatal dopamine function in the rat.
Topics: Acetylcholine; Animals; Apomorphine; Body Weight; Corpus Striatum; Haloperidol; Humans; Kinetics; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1984 |
Differential alterations in striatal dopamine receptor sensitivity induced by repeated administration of clinically equivalent doses of haloperidol, sulpiride or clozapine in rats.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1984 |
Carrier-added and no-carrier-added syntheses of [18F]spiroperidol and [18F]haloperidol.
Topics: Butyrophenones; Fluorine; Haloperidol; Isotope Labeling; Radioisotopes; Spiperone | 1984 |
Differential effects of chronic clorgyline and amfonelic acid on desensitization of striatal dopamine receptors.
Topics: Animals; Apomorphine; Behavior, Animal; Cerebral Cortex; Clorgyline; Corpus Striatum; Dihydroalprenolol; Haloperidol; Male; Monoamine Oxidase Inhibitors; Nalidixic Acid; Naphthyridines; Propylamines; Rats; Receptors, Dopamine; Spiperone; Thioxanthenes | 1984 |
Caerulein stimulates [3H]-spiperone binding in vivo after long-term haloperidol administration.
Topics: Animals; Binding Sites; Butyrophenones; Ceruletide; Haloperidol; Male; Mice; Receptors, Dopamine; Receptors, Serotonin; Spiperone | 1984 |
[Various methods of overcoming secondary resistance to treatment developing in relation to adaptation to psychotropic drugs during long-term treatment (clinico-experimental study)].
Topics: Adult; Animals; Catalepsy; Corpus Striatum; Disease Models, Animal; Drug Therapy, Combination; Drug Tolerance; Haloperidol; Humans; Male; Mice; Receptors, Dopamine; Schizophrenia, Paranoid; Spiperone; Trifluoperazine | 1984 |
Attenuation by pergolide of haloperidol-induced striatal dopamine receptor density.
Topics: Animals; Corpus Striatum; Ergolines; Guinea Pigs; Haloperidol; Male; Membranes; Pergolide; Receptors, Dopamine; Spiperone | 1984 |
Similar effect of estradiol and haloperidol on experimental tardive dyskinesia in monkeys.
Topics: Animals; Apomorphine; Drug Interactions; Dyskinesia, Drug-Induced; Estradiol; Female; Haloperidol; Macaca fascicularis; Receptors, Dopamine; Spiperone | 1984 |
Enhancement of hypophysectomy-induced dopamine receptor hypersensitivity in male rats by chronic haloperidol administration.
Topics: Animals; Apomorphine; Brain; Female; Haloperidol; Humans; Hypophysectomy; Kinetics; Male; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1984 |
[Effect of repeated haloperidol and apomorphine administration on the development of tolerance for catalepsy and dopamine receptor hypersensitivity in mice].
Topics: Animals; Apomorphine; Catalepsy; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Haloperidol; Humans; Male; Mice; Receptors, Dopamine; Spiperone; Time Factors | 1984 |
Antagonism by supidimide of haloperidol-induced augmentation of [3H]-spiperone binding in rat striatum.
Topics: Animals; Butyrophenones; Corpus Striatum; Diazepam; Haloperidol; Kinetics; Male; Membranes; Phenobarbital; Rats; Rats, Inbred Strains; Spiperone; Thalidomide | 1984 |
Re: Receptor binding of F-18 haloperidol and spiroperidol.
Topics: Animals; Butyrophenones; Fluorine; Haloperidol; Radioisotopes; Radioligand Assay; Receptors, Dopamine; Spiperone | 1984 |
[18F]spiroperidol: a radiopharmaceutical for the in vivo study of the dopamine receptor.
Topics: Animals; Butyrophenones; Cerebellum; Corpus Striatum; Fluorine; Haloperidol; Papio; Radioisotopes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Tomography, Emission-Computed | 1984 |
Trapping of labelled ligands in intact cells: a pitfall in binding studies.
Topics: Animals; Binding, Competitive; Cell Line; Haloperidol; Humans; Kinetics; Lymphocytes; Mice; Neuroblastoma; Receptors, Dopamine; Spiperone; Tritium | 1983 |
Comparison in animal models of 18F-spiroperidol and 18F-haloperidol: potential agents for imaging the dopamine receptor.
Topics: Animals; Brain; Butyrophenones; Fluorine; Haloperidol; Papio; Radioisotopes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1983 |
Chronic ganglioside treatment counteracts the biochemical signs of dopamine receptor supersensitivity induced by chronic haloperidol treatment.
Topics: Animals; Binding Sites; Corpus Striatum; Gangliosides; Haloperidol; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Time Factors | 1983 |
Cyclo(Leu-Gly): a possible treatment for tardive dyskinesia?
Topics: Animals; Apomorphine; Corpus Striatum; Dipeptides; Drug Tolerance; Dyskinesia, Drug-Induced; Haloperidol; Male; Mice; Neuropeptides; Peptides, Cyclic; Spiperone | 1983 |
Dopaminergic receptors in guinea-pig bladder.
Topics: Animals; Domperidone; Dopamine; Guinea Pigs; Haloperidol; In Vitro Techniques; Metoclopramide; Radioligand Assay; Receptors, Dopamine; Spiperone; Urinary Bladder | 1983 |
Lack of potency of metoclopramide's metabolites in various dopaminergic models.
Topics: Animals; Apomorphine; Dopamine; Fluphenazine; Haloperidol; Homovanillic Acid; Humans; Male; Metoclopramide; Prolactin; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Tetrahydronaphthalenes | 1983 |
Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation.
Topics: Aging; Animals; Apomorphine; Corpus Striatum; Haloperidol; Humans; Motor Skills; Rats; Rats, Inbred F344; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1983 |
Interaction between estradiol, prolactin, and striatal dopaminergic mechanisms.
Topics: Animals; Corpus Striatum; Domperidone; Dopamine; Estradiol; Female; Haloperidol; Macaca fascicularis; Movement Disorders; Parkinson Disease; Prolactin; Rats; Spiperone | 1984 |
5-Hydroxytryptamine receptor in rabbit aorta: characterization by butyrophenone analogs.
Topics: Animals; Aorta; Azaperone; Benperidol; Butyrophenones; Haloperidol; In Vitro Techniques; Male; Rabbits; Receptors, Serotonin; Serotonin; Spiperone; Spiro Compounds; Structure-Activity Relationship | 1984 |
Chronic domperidone fails to increase striatal spiperone binding sites despite hyperprolactinemia: comparison with chronic haloperidol.
Topics: Animals; Butyrophenones; Corpus Striatum; Domperidone; Haloperidol; Kinetics; Male; Mice; Mice, Inbred C57BL; Prolactin; Receptors, Dopamine; Spiperone | 1984 |
The effect of drug holidays in an animal model of tardive dyskinesia.
Topics: Animals; Corpus Striatum; Dopamine; Drug Administration Schedule; Dyskinesia, Drug-Induced; Haloperidol; Mice; Models, Biological; Receptors, Dopamine; Spiperone | 1980 |
Behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: studies with chronic clozapine and haloperidol.
Topics: Acetylcholine; Animals; Apomorphine; Behavior, Animal; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Chronic molindone treatment: relative inability to elicit dopamine receptor supersensitivity in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Binding, Competitive; Corpus Striatum; Haloperidol; Humans; Indoles; Male; Molindone; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1982 |
The effect of chronic bromocriptine and L-dopa on spiperone binding and apomorphine-induced stereotypy.
Topics: Animals; Apomorphine; Bromocriptine; Butyrophenones; Corpus Striatum; Dose-Response Relationship, Drug; Haloperidol; Humans; Levodopa; Male; Muridae; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Effects of haloperidol-induced dopamine receptor supersensitivity on kindled seizure development.
Topics: Amygdala; Animals; Bromocriptine; Dose-Response Relationship, Drug; Haloperidol; Kindling, Neurologic; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Seizures; Spiperone; Time Factors | 1983 |
Factors affecting solubilized dopamine-sensitive adenylate cyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cattle; Chlorpromazine; Corpus Striatum; Dopamine; Enzyme Activation; Guanylyl Imidodiphosphate; Haloperidol; Lipids; Magnesium; Solubility; Spiperone | 1983 |
Sensitive periods for the effect of haloperidol on development of striatal dopamine receptors.
Topics: alpha-Methyltyrosine; Animals; Corpus Striatum; Dopamine; Female; Gestational Age; Haloperidol; Levodopa; Methyltyrosines; Pregnancy; Rats; Receptors, Dopamine; Spiperone | 1983 |
77Br-p-bromospiperone: a ligand for in vivo labelling of dopamine receptors.
Topics: Animals; Brain; Bromine; Butyrophenones; Cerebellum; Corpus Striatum; Flupenthixol; Haloperidol; Male; Radioisotopes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Tissue Distribution | 1983 |
L-5-Hydroxytryptophan-induced drinking in rats: possible mechanisms for induction.
Topics: 5-Hydroxytryptophan; Animals; Captopril; Clonidine; Drinking; Drug Interactions; Female; Haloperidol; Propranolol; Rats; Spiperone; Stimulation, Chemical | 1981 |
Is there a connection between high affinity 3H-spiperone binding sites and DA-sensitive adenylate cyclase in corpus striatum?
Topics: Adenylyl Cyclases; Animals; Binding Sites; Butyrophenones; Corpus Striatum; Dopamine; Guanosine Triphosphate; Haloperidol; In Vitro Techniques; Male; Phenethylamines; Phenoxybenzamine; Rats; Spiperone | 1980 |
Reversal of respiratory responses to dopamine after dopamine antagonists.
Topics: Animals; Apomorphine; Cats; Chlorpromazine; Dopamine; Dopamine Antagonists; Female; Haloperidol; Male; Nitrogen; Oxygen; Perphenazine; Respiration; Spiperone | 1982 |
The effect of chronic L-dopa administration on supersensitive pre- and postsynaptic dopaminergic receptors in rat brain.
Topics: Animals; Brain; Haloperidol; Hydrazines; Levodopa; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1982 |
Factors contributing to the up regulation of dopaminergic receptors by chronic haloperidol.
Topics: Animals; Corpus Striatum; Dyskinesia, Drug-Induced; Haloperidol; Humans; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Time Factors | 1982 |
Study on some compensatory responses of dopaminergic system in aging rats.
Topics: Aging; Animals; Apomorphine; Butyrophenones; Corpus Striatum; Feedback; Haloperidol; Homovanillic Acid; Male; Rats; Receptors, Dopamine; Spiperone | 1982 |
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.
Topics: Animals; Binding, Competitive; Butyrophenones; Chemical Phenomena; Chemistry; Clozapine; Corpus Striatum; Crystallography; Haloperidol; In Vitro Techniques; Molecular Conformation; Piperazines; Pyrimidines; Rats; Receptors, Dopamine; Spiperone; X-Ray Diffraction | 1982 |
Evidence for the presence of D2 and 5-HT2 receptors in the human prefrontal cortex.
Topics: Binding, Competitive; Cerebral Cortex; Haloperidol; Humans; Kinetics; Membranes; Receptors, Dopamine; Receptors, Serotonin; Spiperone; Stereoisomerism | 1982 |
Chronic haloperidol does not increase specific dopamine receptor binding in rat frontal cortex.
Topics: Animals; Drug Tolerance; Frontal Lobe; Haloperidol; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1982 |
Dopamine-mediated behaviour and 3H-spiperone binding to striatal membranes in rats after nine months haloperidol administration.
Topics: Animals; Behavior, Animal; Butyrophenones; Corpus Striatum; Dopamine; Haloperidol; Humans; Male; Membranes; Mice; Motor Activity; Spiperone; Stereotyped Behavior | 1980 |
Amantadine reduces haloperidol-induced dopamine receptor hypersensitivity in the striatum.
Topics: Amantadine; Animals; Apomorphine; Corpus Striatum; Haloperidol; Humans; In Vitro Techniques; Kinetics; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1980 |
Alteration in dopaminergic and muscarinic cholinergic receptors after subchronic treatment with haloperidol in the developing rat brain.
Topics: Animals; Animals, Newborn; Brain; Catalepsy; Corpus Striatum; Female; Haloperidol; Humans; Male; Motor Activity; Pilocarpine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Muscarinic; Spiperone | 1981 |
Hypophysectomy induced hypersensitivity to dopamine: antagonism by estrogen.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Estradiol; Female; Haloperidol; Humans; Hypophysectomy; Pituitary Gland; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior | 1981 |
Aging and the regulation of striatal dopaminergic mechanisms in mice.
Topics: Aging; Animals; Apomorphine; Bromocriptine; Corpus Striatum; Haloperidol; Humans; Male; Mice; Mice, Inbred C57BL; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1981 |
Effects of prenatal treatment of rats with haloperidol due to altered drug distribution in neonatal brain.
Topics: Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Brain; Female; Haloperidol; Humans; Kinetics; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior | 1981 |
Regional blockade by neuroleptic drugs of in vivo 3H-spiperone binding in the rat brain. Relation to blockade of apomorphine induced hyperactivity and stereotypies.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butyrophenones; Chlorpromazine; Clozapine; Haloperidol; Humans; Hyperkinesis; Kinetics; Organ Specificity; Rats; Receptors, Dopamine; Receptors, Drug; Spiperone; Stereotyped Behavior; Sulpiride; Thioridazine | 1981 |
Chronic haloperidol treatment potentiates apomorphine- and ethanol-induced hypothermia in the rat.
Topics: Animals; Apomorphine; Binding Sites; Corpus Striatum; Drug Synergism; Ethanol; Haloperidol; Humans; Hypothermia; Kinetics; Male; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior | 1982 |
Estrogen inhibits the dopaminergic supersensitivity induced by neuroleptics.
Topics: Animals; Apomorphine; Drug Administration Schedule; Estradiol; Female; Haloperidol; Humans; In Vitro Techniques; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Neuronal mechanisms regulating ethanol effects on the dopaminergic system.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alcoholism; Animals; Dopamine; Ethanol; Haloperidol; Humans; Male; Morphine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Sulpiride | 1982 |
The effect of altered dopaminergic activity on food intake in the rat: evidence for an optimal level of dopaminergic activity for behavior.
Topics: Amphetamine; Amphetamines; Animals; Apomorphine; Brain; Cocaine; Dextroamphetamine; Dopamine; Feeding Behavior; Haloperidol; Levodopa; Methylphenidate; Rats; Spiperone | 1980 |
Biochemical mechanism of tolerance to neuroleptic drugs; regional differences in rat brain.
Topics: Animals; Butyrophenones; Caudate Nucleus; Cerebral Cortex; Dopamine; Drug Tolerance; Fluphenazine; Haloperidol; Homovanillic Acid; Rats; Spiperone | 1981 |
Chronic lead treatment induces in rat a specific and differential effect on dopamine receptors in different brain areas.
Topics: Adenylyl Cyclases; Animals; Brain; Dopamine; Haloperidol; Kinetics; Lead Poisoning; Motor Activity; Organ Specificity; Rats; Receptors, Dopamine; Spiperone; Sulpiride; Tritium | 1981 |
High-performance liquid chromatographic determination of haloperidol in plasma.
Topics: Chromatography, High Pressure Liquid; Haloperidol; Humans; Spiperone | 1981 |
Increase in in vivo (3H) spiperone binding in the rat hippocampal formation and striatum after repeated treatment with haloperidol.
Topics: Animals; Butyrophenones; Corpus Striatum; Haloperidol; Hippocampus; Kinetics; Male; Rats; Receptors, Dopamine; Spiperone | 1981 |
Effect of chronic sulpiride on striatal spiperone binding.
Topics: Animals; Butyrophenones; Corpus Striatum; Haloperidol; Rats; Spiperone; Sulpiride; Tritium; Visual Cortex | 1980 |
Direct binding of 3H-lisuride to adrenergic and serotonergic receptors.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Ergolines; Haloperidol; In Vitro Techniques; Kinetics; Lisuride; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Spiperone | 1981 |
Sulpiride and the role of dopaminergic receptor blockade in the antipsychotic activity of neuroleptics.
Topics: Adenylyl Cyclases; Animals; Corpus Striatum; Drug Interactions; Haloperidol; Male; Rats; Receptors, Dopamine; Spiperone; Sulpiride | 1981 |
Effects of oxolinic acid on the sleep-wakefulness cycle of the rat.
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Haloperidol; Male; Oxolinic Acid; Rats; Rats, Inbred Strains; Receptors, Serotonin; Sleep; Spiperone; Wakefulness | 1981 |
Individual differences in the response of dopamine receptor number to chronic haloperidol treatment.
Topics: Animals; Corpus Striatum; Haloperidol; Individuality; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred CBA; Rats; Receptors, Dopamine; Spiperone; Time Factors; Tritium | 1981 |
Receptor supersensitivity: relationships to cerebral anatomy and histopathology of schizophrenia.
Topics: Afferent Pathways; Apomorphine; Brain; Corpus Striatum; Gliosis; Haloperidol; Humans; Receptors, Dopamine; Schizophrenia; Spiperone | 1981 |
Prolactin-releasing effect of a novel anti-dopaminergic drug, domperidone, in the rat.
Topics: Animals; Benzimidazoles; Bromocriptine; Caudate Nucleus; Corpus Striatum; Dopamine Antagonists; Haloperidol; Male; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Receptors, Dopamine; Spiperone | 1980 |
Biochemical characterization of the dopaminergic innervation of the rat septum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Animals; Apomorphine; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Haloperidol; Kinetics; Male; Rats; Receptors, Dopamine; Septum Pellucidum; Spiperone | 1980 |
Differentiation by ascorbic acid of dopamine agonist and antagonist binding sites in striatum.
Topics: Animals; Apomorphine; Ascorbic Acid; Corpus Striatum; Dopamine Antagonists; Haloperidol; Male; Naphthols; Oxidation-Reduction; Rats; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes | 1980 |
Hypophysectomy prevents the striatal dopamine receptor supersensitivity produced by chronic haloperidol treatment.
Topics: Animals; Corpus Striatum; Haloperidol; Hypophysectomy; Kinetics; Male; Rats; Receptors, Dopamine; Spiperone | 1980 |
Aging process affects a single class of dopamine receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Aging; Animals; Corpus Striatum; Haloperidol; Humans; Male; Receptors, Dopamine; Spiperone; Sulpiride | 1980 |
Effects of haloperidol and d-amphetamine on in vivo 3H-spiroperiodol binding in the rat forebrain(1).
Topics: Animals; Brain; Butyrophenones; Dextroamphetamine; Haloperidol; Male; Rats; Spiperone | 1980 |
No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N-methylspiperone.
Topics: Adult; Carbon Radioisotopes; Cerebellum; Dopamine Agonists; Female; Frontal Lobe; Haloperidol; Humans; Male; Putamen; Radioligand Assay; Receptors, Dopamine D2; Reproducibility of Results; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed | 1995 |
Evidence for an action of araboascorbic acid on dopaminergic pathways of the corpus striatum.
Topics: Animals; Ascorbic Acid; Catalepsy; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Female; Haloperidol; Male; Mice; Neural Pathways; Spiperone | 1995 |
Pharmacological characterisation of high affinity [35S]GTP gamma S binding in membranes from CHO-K1 cells stably expressing rat D2(short) dopamine receptors.
Topics: Animals; Butaclamol; Cell Membrane; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Kinetics; Rats; Receptors, Dopamine D2; Recombinant Proteins; Spiperone; Stereoisomerism; Sulfur Radioisotopes | 1995 |
Behavioral and biochemical changes after bilateral electrolytic lesions of the red nucleus of rat.
Topics: Animals; Apomorphine; Azepines; Behavior, Animal; Body Temperature; Brain Chemistry; Catalepsy; Dopamine; Dopamine Agonists; Haloperidol; Male; Rats; Rats, Wistar; Red Nucleus; Serotonin; Spiperone; Stereotyped Behavior | 1995 |
D2-specific discriminative stimuli: parameters, blocking, and rebound.
Topics: Animals; Cues; Discrimination, Psychological; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Ergolines; Food Deprivation; Haloperidol; Male; Quinpirole; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Spiperone | 1995 |
Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants.
Topics: Animals; Benzamides; Cell Line; CHO Cells; Clozapine; Colforsin; Cricetinae; Cyclic AMP; Dinoprostone; Dopamine; Haloperidol; HeLa Cells; Humans; Raclopride; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone; Transfection | 1995 |
Myocardial accumulation of a dopamine D2 receptor-binding radioligand, 2'-iodospiperone.
Topics: Animals; Butaclamol; Haloperidol; Heart; Injections, Intravenous; Iodine Radioisotopes; Male; Mice; Myocardium; Radionuclide Imaging; Rats; Receptors, Dopamine D2; Spiperone; Tissue Distribution | 1993 |
Haloperidol blocks the uptake of [18F]N-methylspiroperidol by extrastriatal dopamine receptors in schizophrenic patients.
Topics: Adult; Brain; Fluorine Radioisotopes; Haloperidol; Humans; Receptors, Dopamine; Schizophrenia; Spiperone; Tomography, Emission-Computed | 1995 |
In vivo D2 dopamine receptor density in psychotic and nonpsychotic patients with bipolar disorder.
Topics: Adult; Bipolar Disorder; Brain; Carbon Radioisotopes; Caudate Nucleus; Female; Haloperidol; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Psychotic Disorders; Putamen; Receptors, Dopamine; Schizophrenia; Spiperone; Tomography, Emission-Computed | 1995 |
Behavioral effects of dopaminergic agonists and antagonists alone and in combination in the squirrel monkey.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Benzazepines; Conditioning, Operant; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Ergolines; Haloperidol; Male; Quinpirole; Reinforcement Schedule; Saimiri; Spiperone | 1993 |
Effects of ceruletide on the dopamine receptor-adenylate cyclase system in striatum and frontal cortex of rats chronically treated with haloperidol.
Topics: Adenylyl Cyclases; Animals; Benzazepines; Ceruletide; Frontal Lobe; Guanylyl Imidodiphosphate; Haloperidol; Male; Neostriatum; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone | 1993 |
N-(1-arylpropionyl)-4-aryltetrahydropyridines, a new class of high-affinity selective sigma receptor ligands.
Topics: Animals; Antipsychotic Agents; Binding Sites; Binding, Competitive; Cattle; Cerebellum; Dihydropyridines; Haloperidol; Ketanserin; Propiophenones; Pyridines; Radioligand Assay; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, sigma; Spiperone | 1993 |
Characterization of the functional activity of dopamine ligands at human recombinant dopamine D4 receptors.
Topics: Animals; Cell Line; Clozapine; DNA; Dopamine; Dopamine Agents; Ergolines; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Ligands; Moths; Quinpirole; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone; Sulfur Radioisotopes; Tritium | 1994 |
Inhibitory action of haloperidol, spiperone and SCH23390 on calcium currents in rat retinal ganglion cells.
Topics: Action Potentials; Animals; Benzazepines; Calcium Channels; Cells, Cultured; Dopamine; Haloperidol; Ion Channel Gating; Patch-Clamp Techniques; Rats; Retinal Ganglion Cells; Spiperone | 1994 |
Single-unit responses of serotonergic dorsal raphe neurons to 5-HT1A agonist and antagonist drug administration in behaving cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Cats; Depression, Chemical; Dopamine D2 Receptor Antagonists; Female; Haloperidol; Male; Membrane Potentials; Neurons; Premedication; Raphe Nuclei; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone | 1994 |
Pharmacological studies with two new ergoline derivatives, the potential antipsychotics LEK-8829 and LEK-8841.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Antipsychotic Agents; Benzazepines; Blood Pressure; Catalepsy; Clozapine; Dose-Response Relationship, Drug; Ergolines; Haloperidol; Lysergic Acid; Male; Mice; Muscarinic Antagonists; Rats; Serotonin Antagonists; Spiperone | 1994 |
Haloperidol-induced behavioral supersensitivity is increased by monosialoganglioside treatment in rats without affecting spiroperidol-binding.
Topics: Animals; Corpus Striatum; Dose-Response Relationship, Drug; G(M1) Ganglioside; Gangliosides; Haloperidol; Male; Motor Activity; Rats; Rats, Wistar; Receptors, Dopamine D2; Spiperone | 1994 |
Effect of chronic haloperidol treatment on dopamine-induced inositol phosphate formation in rat brain slices.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Brain; Corpus Striatum; Dopamine; Dopamine Antagonists; Frontal Lobe; Haloperidol; Hippocampus; In Vitro Techniques; Inositol; Inositol Phosphates; Male; Organ Specificity; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Reference Values; Spiperone | 1994 |
(+)-[C-11]-cis-N-benzyl-normetazocine: a selective ligand for sigma receptors in vivo.
Topics: Animals; Binding, Competitive; Brain; Carbon Radioisotopes; Cyclazocine; Haloperidol; Kinetics; Ligands; Male; Mice; Organ Specificity; Pentazocine; Phencyclidine; Piperidines; Receptors, sigma; Spiperone; Stereoisomerism; Tissue Distribution; Tomography, Emission-Computed | 1994 |
Pharmacological profile of AD-5423, a novel antipsychotic with both potent dopamine-D2 and serotonin-S2 antagonist properties.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Biogenic Monoamines; Clozapine; Dogs; Dopamine D2 Receptor Antagonists; Guinea Pigs; Haloperidol; Macaca fascicularis; Male; Mice; Mice, Inbred Strains; Neurotransmitter Uptake Inhibitors; Piperazines; Piperidines; Prosencephalon; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Tritium | 1993 |
Convergent regulation by ciliary neurotrophic factor and dopamine of tyrosine hydroxylase expression in cultures of rat substantia nigra.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Cells, Cultured; Ciliary Neurotrophic Factor; Dopamine; Dose-Response Relationship, Drug; Embryo, Mammalian; Ergolines; Glial Fibrillary Acidic Protein; Haloperidol; Kinetics; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Phosphopyruvate Hydratase; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Recombinant Proteins; Spiperone; Substantia Nigra; Sulpiride; Time Factors; Tyrosine 3-Monooxygenase | 1993 |
Anti-idiotypes against an anti-haloperidol antibody bind to sigma receptors.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Brain; Cattle; Haloperidol; Immune Sera; Immunoglobulin G; Immunoglobulin Idiotypes; Mice; Mice, Inbred BALB C; Precipitin Tests; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, sigma; Spiperone | 1993 |
Lacrimal secretion stimulants: sigma receptors and drug implications.
Topics: Animals; Bromhexine; Dose-Response Relationship, Drug; Eye Proteins; Female; Guanidines; Haloperidol; In Vitro Techniques; Lacrimal Apparatus; Male; Rabbits; Receptors, sigma; Secretory Rate; Spiperone; Tears | 1993 |
Effects of long-term treatment of haloperidol on D2 dopamine receptors in various areas of rat brain.
Topics: Animals; Binding Sites; Brain; Haloperidol; In Vitro Techniques; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Spiperone | 1993 |
Selective D1 and D2 dopamine receptor antagonists produce differential effects on reaction time in the rat.
Topics: Acoustic Stimulation; Animals; Avoidance Learning; Benzazepines; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Photic Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Dopamine D1; Spiperone | 1993 |
The effect of haloperidol on D2 dopamine receptor subtype mRNA levels in the brain.
Topics: Animals; Base Sequence; Blotting, Northern; Brain; Corpus Striatum; Haloperidol; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Receptors, Dopamine D2; RNA, Messenger; Spiperone | 1994 |
The presence of sigma-receptors in the lacrimal gland.
Topics: Animals; Binding, Competitive; Cell Membrane; Female; Guanidines; Haloperidol; Lacrimal Apparatus; Male; Rabbits; Radioligand Assay; Receptors, sigma; Spiperone | 1993 |
3H-spiroperidol binding to peripheral mononuclear cells in schizophrenic and healthy subjects.
Topics: Adult; Binding, Competitive; Clozapine; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Radioligand Assay; Receptors, Dopamine; Schizophrenia; Schizophrenic Psychology; Spiperone | 1993 |
Brain dopamine transporter: gender differences and effect of chronic haloperidol.
Topics: Animals; Brain Chemistry; Carrier Proteins; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Haloperidol; In Situ Hybridization; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA, Messenger; Sex Characteristics; Spiperone; Substantia Nigra | 1995 |
Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors.
Topics: Animals; Anisoles; Dehydroepiandrosterone; Drug Synergism; Female; Guanidines; Haloperidol; Hippocampus; Iontophoresis; Ligands; Male; N-Methylaspartate; Pertussis Toxin; Pregnenolone; Progesterone; Propylamines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Spiperone; Virulence Factors, Bordetella | 1996 |
[The affinities of mosapramine for the dopamine receptor subtypes in human cell lines expressing D2, D3 and D4 receptors].
Topics: Antipsychotic Agents; Benzazepines; Cell Line; Clozapine; Haloperidol; Humans; Raclopride; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, Dopamine D5; Risperidone; Salicylamides; Spiperone | 1996 |
Long-term neuroleptic treatments counteract dopamine D2 agonist inhibition of adenylate cyclase but do not affect pertussis toxin ADP-ribosylation in the rat brain.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Antipsychotic Agents; Benzazepines; Brain; Brain Chemistry; Chlorpromazine; Dopamine Agonists; Dopamine Antagonists; Haloperidol; Male; Neostriatum; Pertussis Toxin; Rats; Rats, Wistar; Receptors, Dopamine D2; Spiperone; Virulence Factors, Bordetella | 1996 |
Subchronic administration of clozapine, but not haloperidol or metoclopramide, decreases dopamine D2 receptor messenger RNA levels in the nucleus accumbens and caudate-putamen in rats.
Topics: Actins; Animals; Antipsychotic Agents; Blotting, Northern; Brain Chemistry; Caudate Nucleus; Clozapine; Dopamine Antagonists; Haloperidol; Male; Metoclopramide; Nucleus Accumbens; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA, Messenger; Spiperone | 1996 |
Dopamine receptor binding of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)- 4-oxobutyl]-1,2,3,6-tetrahydropyridine (HPTP), an intermediate metabolite of haloperidol.
Topics: Animals; Antipsychotic Agents; Benzazepines; Binding, Competitive; Haloperidol; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Tritium | 1996 |
3H-spiperone binding to peripheral mononuclear cells in psychiatric in-patients.
Topics: Adult; Binding, Competitive; Clozapine; Female; Haloperidol; Hospitalization; Humans; Lymphocytes; Male; Middle Aged; Schizophrenia; Spiperone | 1996 |
Neuroleptic monitoring: relation between antipsychotic efficiency and radioreceptor assay of serum haloperidol.
Topics: Adult; Antipsychotic Agents; Binding, Competitive; Dopamine D2 Receptor Antagonists; Double-Blind Method; Female; Haloperidol; Humans; Isotope Labeling; Male; Middle Aged; Protein Binding; Psychiatric Status Rating Scales; Psychotic Disorders; Radioligand Assay; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tritium | 1996 |
Pharmacological characterization and autoradiographic localization of dopamine receptors in the rat adrenal medulla.
Topics: Adrenal Medulla; Animals; Autoradiography; Benzazepines; Butaclamol; Corpus Striatum; Haloperidol; Male; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Sulpiride | 1996 |
Haloperidol and spiperone potentiate murine splenic B cell proliferation.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Anti-Idiotypic; B-Lymphocytes; Dopamine; Dopamine Antagonists; Haloperidol; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Receptors, sigma; Serotonin; Spiperone | 1996 |
Dopamine receptor subtypes: differential regulation after 8 months treatment with antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Benzamides; Benzazepines; Brain; Clozapine; Corpus Striatum; Haloperidol; Iodine Radioisotopes; Male; Organ Specificity; Raclopride; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin; Salicylamides; Spiperone; Tetrahydronaphthalenes; Time Factors; Tritium; Up-Regulation | 1997 |
Quantification of neuroreceptors in the living human brain: III. D2-like dopamine receptors: theory, validation, and changes during normal aging.
Topics: Aging; Algorithms; Animals; Brain; Brain Chemistry; Computer Simulation; Corpus Striatum; Dopamine Agonists; Guinea Pigs; Haloperidol; Humans; Image Processing, Computer-Assisted; Kinetics; Male; Models, Neurological; Nerve Tissue Proteins; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed | 1997 |
The behavioural effects of pramipexole, a novel dopamine receptor agonist.
Topics: Animals; Antiparkinson Agents; Benzazepines; Benzothiazoles; Body Temperature; Catalepsy; Clozapine; Dopamine Agents; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Haloperidol; Injections, Subcutaneous; Levodopa; Male; Mice; Motor Activity; Pramipexole; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Spiperone; Stereotyped Behavior; Sulpiride; Thiazoles | 1997 |
The effect of streptozotocin-induced diabetes on dopamine2, serotonin1A and serotonin2A receptors in the rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Diabetes Mellitus, Experimental; Dopamine Antagonists; Frontal Lobe; Haloperidol; Hippocampus; Ketanserin; Male; Neostriatum; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Streptozocin | 1997 |
A sensitive assay for studying dopaminergic activity in cultures of rat pituitary cells.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Bromocriptine; Cell Count; Cells, Cultured; Cyproheptadine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Evaluation, Preclinical; Female; Haloperidol; Pituitary Gland; Prolactin; Rats; Rats, Wistar; Spiperone | 1997 |
The role of striatal glutamatergic system in haloperidol-induced dopamine receptor supersensitivity and effects of monosialoganglioside GM1.
Topics: Animals; Aspartic Acid; Dopamine Antagonists; G(M1) Ganglioside; Glutamic Acid; Haloperidol; Male; Neostriatum; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Glutamate; Spiperone | 1997 |
Effects of haloperidol and GM1 ganglioside treatment on striatal D2 receptor binding and dopamine turnover.
Topics: Animals; Corpus Striatum; Dopamine; Dopamine Antagonists; Drug Administration Schedule; Drug Synergism; G(M1) Ganglioside; Haloperidol; Kinetics; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Spiperone; Tritium | 1998 |
Differential effects on D2 dopamine receptor and prolactin gene expression by haloperidol and aripiprazole in the rat pituitary.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Aripiprazole; Cell Membrane; Gene Expression Regulation; Haloperidol; Male; Piperazines; Pituitary Gland; Prolactin; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Ribonucleases; RNA, Messenger; Spiperone | 1998 |
Sensitivity of the N-methyl-D-aspartate receptor channel to butyrophenones is dependent on the epsilon2 subunit.
Topics: Amino Acid Substitution; Animals; Antipsychotic Agents; Butyrophenones; Droperidol; Haloperidol; Magnesium; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Spiperone; Xenopus laevis | 1998 |
Modification of sexual behavior of Long-Evans male rats by drugs acting on the 5-HT1A receptor.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain Chemistry; Buspirone; Copulation; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Penile Erection; Penis; Piperazines; Pyrimidines; Rats; Rats, Long-Evans; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex; Serotonin; Serotonin Receptor Agonists; Spiperone | 1999 |
Neuropharmacological assessment of potential dopamine D4 receptor-selective radioligands.
Topics: Aminopyridines; Animals; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Dopamine Agents; Dopamine Antagonists; Haloperidol; Humans; In Vitro Techniques; Ligands; Male; Piperidines; Prosencephalon; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4; Spiperone; Tritium | 1999 |
Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.
Topics: Allosteric Site; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Binding Sites; Biological Transport; Cell Membrane; CHO Cells; Cricetinae; Fluorescent Dyes; Flupenthixol; Haloperidol; Molecular Structure; Prazosin; Progesterone; Propranolol; Protein Binding; Rhodamine 123; Spiperone | 1999 |
Chronic haloperidol and clozapine administration increases the number of cortical NMDA receptors in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antipsychotic Agents; Autoradiography; Cerebral Cortex; Clozapine; Corpus Striatum; Dizocilpine Maleate; Haloperidol; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Spiperone; Tritium | 1999 |
Dihydroetorphine-induced place preference was mediated by dopamine D1 receptors in rats.
Topics: Animals; Behavior, Animal; Benzazepines; Dopamine Agonists; Etorphine; Haloperidol; Male; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Sulpiride | 1999 |
Synthesis and preliminary pharmacological investigations of 1-(1,2-dihydro-2-acenaphthylenyl)piperazine derivatives as potential atypical antipsychotic agents in mice.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Binding, Competitive; Brain Chemistry; Catalepsy; Chemical Phenomena; Chemistry, Physical; Dopamine Agonists; Dopamine Antagonists; Haloperidol; Mice; Naphthalenes; Piperazines; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Spiperone; Stereotyped Behavior | 1999 |
Enhanced striatal dopamine D(2) receptor-induced [35S]GTPgammaS binding after haloperidol treatment.
Topics: Animals; Apomorphine; Binding, Competitive; Catalepsy; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Spiperone; Sulfur Radioisotopes; Tritium; Up-Regulation | 1999 |
Dopamine receptor antagonists modulate glucose uptake in rat pheochromocytoma (PC12) cells.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Benzazepines; Biological Transport; Chlorpromazine; Clozapine; Dizocilpine Maleate; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Fluphenazine; Glucose; Haloperidol; PC12 Cells; Pimozide; Rats; Receptors, Dopamine D2; Spiperone; Sulpiride; Tritium | 1999 |
Pharmacology of quinpirole-stimulated [35S]GTPgammaS binding: discrepancy with receptor binding profile.
Topics: Animals; Benzazepines; Binding, Competitive; Clorgyline; Clozapine; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Membranes; Monoamine Oxidase Inhibitors; Quinpirole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Selegiline; Spiperone; Sulfur Radioisotopes; Thiazoles | 2000 |
Neuroleptics ameliorate phencyclidine-induced impairments of short-term memory.
Topics: Animals; Antipsychotic Agents; Benzazepines; Brain; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Interneurons; Male; Memory Disorders; Memory, Short-Term; Phencyclidine; Rats; Risperidone; Schizophrenia; Spiperone | 2000 |
Reconstitution of functional dopamine D(2s) receptor by co-expression of amino- and carboxyl-terminal receptor fragments.
Topics: Animals; Apomorphine; Binding, Competitive; Clozapine; Colforsin; COS Cells; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Membranes; Peptide Fragments; Pergolide; Quinpirole; Radioligand Assay; Rats; Receptors, Dopamine D2; Recombinant Fusion Proteins; Spiperone; Transfection; Tritium | 2000 |
Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release.
Topics: Animals; Binding, Competitive; Carbon Radioisotopes; Female; Haloperidol; Neostriatum; Radioligand Assay; Receptors, Dopamine D2; Spiperone; Swine; Tomography, Emission-Computed | 2000 |
Distinct functions of the two isoforms of dopamine D2 receptors.
Topics: Animals; Apomorphine; Benzazepines; Catalepsy; Chimera; Dopamine; Dopamine Agonists; Dopamine Antagonists; Haloperidol; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Protein Isoforms; Quinpirole; Receptors, Dopamine D2; Signal Transduction; Spiperone; Synapses | 2000 |
Possible involvement of dopamine and dopamine2 receptors in the inhibitions of gastric emptying by escin Ib in mice.
Topics: alpha-Methyltyrosine; Animals; Benzazepines; Domperidone; Dopamine; Dose-Response Relationship, Drug; Escin; Gastric Emptying; Haloperidol; Male; Metoclopramide; Mice; Oxidopamine; Receptors, Dopamine; Reserpine; Spiperone | 2000 |
The effect of nicotine and haloperidol co-treatment on nicotinic receptor levels in the rat brain.
Topics: Aconitine; Animals; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Dopamine Antagonists; Haloperidol; Insecticides; Male; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, Nicotinic; Schizophrenia; Smoking; Spiperone; Tritium | 2001 |
[Effect of inhibitors of synthesis of dopamine and its antagonists on Hydra attenuata regeneration].
Topics: alpha-Methyltyrosine; Animals; Dopamine; Dopamine Antagonists; Haloperidol; Hydra; Methyldopa; Monoiodotyrosine; Regeneration; Spiperone | 2000 |
D2 but not D3 receptors are elevated after 9 or 11 months chronic haloperidol treatment: influence of withdrawal period.
Topics: Animals; Brain; Dopamine Antagonists; Drug Administration Schedule; Haloperidol; Iodine Radioisotopes; Male; Neurons; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Spiperone; Substance Withdrawal Syndrome; Tetrahydronaphthalenes; Time Factors; Tritium; Up-Regulation | 2001 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
Differential effects of 5-HT1A receptor deletion upon basal and fluoxetine-evoked 5-HT concentrations as revealed by in vivo microdialysis.
Topics: Animals; Brain; Carrier Proteins; Corpus Striatum; Dopamine; Fluoxetine; Haloperidol; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Knockout; Microdialysis; Nerve Tissue Proteins; Receptors, Presynaptic; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Spiperone | 2001 |
Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study).
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Male; Microdialysis; Rats; Rats, Wistar; Receptors, Dopamine D3; Spiperone; Tetrahydronaphthalenes | 2001 |
Pharmacological evaluation of (+)-2- [123I]A-69024: a radioligand for in vivo studies of dopamine D1 receptors.
Topics: Animals; Benzazepines; Brain; Cerebellum; Clozapine; Corpus Striatum; Dopamine Antagonists; Haloperidol; Injections, Intravenous; Iodine Radioisotopes; Ketanserin; Ligands; Male; Papaverine; Rats; Rats, Wistar; Receptors, Dopamine D1; Spiperone; Stereoisomerism; Tetrahydroisoquinolines; Tetrahydronaphthalenes; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2001 |
Dosing time-dependent tolerance of catalepsy by repetitive administration of haloperidol in mice.
Topics: Animals; Antipsychotic Agents; Catalepsy; Circadian Rhythm; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Tolerance; Haloperidol; Male; Mice; Mice, Inbred ICR; Neostriatum; Receptors, Dopamine D2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spiperone; Time Factors | 2001 |
Determination of dopamine D(4) receptor density in rat striatum using PB12 as a probe.
Topics: Animals; Benzamides; Binding, Competitive; Corpus Striatum; Dose-Response Relationship, Drug; Haloperidol; Kinetics; Male; Membranes; Piperazines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Spiperone; Time Factors; Tritium | 2001 |
Modulation of dopamine uptake in rat nucleus accumbens: effect of specific dopamine receptor antagonists and sigma ligands.
Topics: Animals; Antipsychotic Agents; Carbazoles; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Haloperidol; Ligands; Neurons; Nomifensine; Nucleus Accumbens; Phenazocine; Progesterone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, sigma; Spiperone; Sulpiride; Synaptosomes; Tritium | 2001 |
Decreased [(3)H]spiperone binding in the anterior cingulate cortex of schizophrenia patients: an autoradiographic study.
Topics: Adult; Aged; Antipsychotic Agents; Binding Sites; Binding, Competitive; Butaclamol; Down-Regulation; Gyrus Cinguli; Haloperidol; Humans; Mianserin; Middle Aged; Neurons; Neurotransmitter Agents; Radioligand Assay; Receptors, Neurotransmitter; Risperidone; Schizophrenia; Spiperone; Tritium | 2002 |
Apomorphine induces trophic factors that support fetal rat mesencephalic dopaminergic neurons in cultures.
Topics: Animals; Apomorphine; Benzazepines; Brain-Derived Neurotrophic Factor; Cell Count; Cell Culture Techniques; Dopamine; Dopamine Agonists; Dopamine Antagonists; Enzyme-Linked Immunosorbent Assay; Glial Cell Line-Derived Neurotrophic Factor; Haloperidol; Mesencephalon; Nerve Growth Factors; Neurons; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spiperone; Tyrosine 3-Monooxygenase | 2002 |
The role of catecholamines in retention performance of a partially baited radial eight-arm maze for rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Benzazepines; Dopamine; Dopamine Antagonists; Haloperidol; Male; Maze Learning; Memory; Norepinephrine; Prazosin; Propranolol; Rats; Rats, Wistar; Space Perception; Spiperone; Yohimbine | 2002 |
[SPIROPERIDOL].
Topics: Catatonia; Geriatrics; Hallucinations; Haloperidol; Humans; Hypnotics and Sedatives; Paranoid Disorders; Paresis; Schizophrenia; Spiperone | 1963 |
Direct activation by dopamine of recombinant human 5-HT1A receptors: comparison with human 5-HT2C and 5-HT3 receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Chelating Agents; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanosine Diphosphate; Haloperidol; Humans; Indazoles; Inhibitory Concentration 50; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Pertussis Toxin; Piperazine; Piperazines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT2; Receptors, Serotonin, 5-HT3; Recombinant Proteins; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Thionucleotides; Tropanes; Xenopus laevis | 2003 |
Elevated neuronal nitric oxide synthase expression in chronic haloperidol-treated rats.
Topics: Animals; Basal Ganglia; Behavior, Animal; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Dopamine Agonists; Dopamine Antagonists; Haloperidol; Immunohistochemistry; In Situ Hybridization; Male; Neostriatum; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA, Messenger; Spiperone | 2003 |
Simultaneous analysis of haloperidol, its three metabolites and two other butyrophenone-type neuroleptics by high performance liquid chromatography with dual ultraviolet detection.
Topics: Antipsychotic Agents; Chromatography, High Pressure Liquid; Droperidol; Haloperidol; Humans; Melanins; Orosomucoid; Protein Binding; Reproducibility of Results; Serum Albumin; Spectrophotometry, Ultraviolet; Spiperone | 2006 |
Mechanisms for metoclopramide-mediated sensitization and haloperidol-induced catalepsy in rats.
Topics: Animals; Behavior, Animal; Binding, Competitive; Catalepsy; Cerebral Cortex; Dizocilpine Maleate; Dopamine Antagonists; Haloperidol; Male; Metoclopramide; Neostriatum; Rats; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Spiperone | 2008 |
Haloperidol, spiperone, pimozide and aripiprazole reduce intracellular dopamine content in PC12 cells and rat mesencephalic cultures: Implication of inhibition of vesicular transport.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Aripiprazole; Ascorbic Acid; Biological Transport; Dopamine; Extracellular Space; Gene Expression Regulation, Enzymologic; Haloperidol; Homovanillic Acid; Mesencephalon; Neurons; Pargyline; PC12 Cells; Pimozide; Piperazines; Quinolones; Rats; Spiperone; Transport Vesicles; Tyrosine 3-Monooxygenase | 2010 |
Structure-based drug design for dopamine D3 receptor.
Topics: Animals; Combinatorial Chemistry Techniques; Drug Design; Haloperidol; Humans; Indoles; Mice; Models, Molecular; Molecular Structure; Piperazines; Piperidines; Pyrazoles; Pyridines; Receptors, Dopamine D3; Spiperone; Structure-Activity Relationship; Sulpiride; Thiophenes | 2012 |