spiperone has been researched along with guanosine triphosphate in 73 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 55 (75.34) | 18.7374 |
| 1990's | 16 (21.92) | 18.2507 |
| 2000's | 2 (2.74) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creese, I; Snyder, SH; Usdin, T | 1 |
| Lebovitz, RM; Peroutka, SJ; Snyder, SH | 1 |
| Kumar, BV; Sastry, PS | 1 |
| Andersen, PH; Jansen, JA | 1 |
| Convents, A; De Backer, JP; De Keyser, J; Ebinger, G; Vauquelin, G | 1 |
| Andrade, R; Malenka, RC; Nicoll, RA | 1 |
| Berstein, G; Haga, K; Haga, T; Ichiyama, A; Ohara, K | 1 |
| Urwyler, S | 1 |
| De Backer, JP; De Keyser, J; Ebinger, G; Vauquelin, G; Walraevens, H | 1 |
| De Keyser, J; Ebinger, G; Roos, RA; Vauquelin, G | 1 |
| Segawa, T; Zhang, X | 1 |
| Jenner, P; Kilpatrick, GJ; Marsden, CD | 1 |
| Kidric, M; Petrović, J; Soskić, V; Trajković, D | 1 |
| Lambert, G; Monroe, PJ; Nelson, DL; Yamamura, HI | 1 |
| Lin, C; McGonigle, P; Molinoff, PB | 1 |
| Beart, PM; Cincotta, M; Cook, CJ; de Vries, DJ; Dijkstra, D; Horn, AS; Tepper, P | 1 |
| Goldstein, M | 1 |
| Amlaiky, N; Caron, MG; Falardeau, P; Senogles, SE | 1 |
| Beart, PM; De Vries, DJ | 2 |
| Craig, JC; Findell, PR; Torkelson, SM; Weiner, RI | 1 |
| Andorn, AC; Bacon, BR; Nguyen-Hunh, AT; Parlato, SJ; Stitts, JA | 1 |
| Bernier, MA; Di Paolo, T | 1 |
| Shearman, MS; Strange, PG | 1 |
| Gredal, O; Nielsen, M | 1 |
| Huff, RM; Molinoff, PB | 1 |
| Gawell, L; Hall, H; Köhler, C | 1 |
| Cote, TE; Frey, EA; Sekura, RD | 1 |
| Fujita, M; Nishio, H; Nomura, Y; Segawa, T; Taguchi, J | 1 |
| Snyder, SH | 1 |
| Battaglia, G; Titeler, M | 1 |
| Dvorkin, B; Horowitz, SG; Makman, MH; Thal, LJ | 2 |
| Nomura, Y; Oki, K; Segawa, T | 1 |
| Kuno, T; Tanaka, C | 1 |
| Kuno, T; Shirakawa, O; Tanaka, C | 1 |
| Kubo, N; Kuno, T; Saijoh, K; Shirakawa, O; Tanaka, C | 1 |
| Cote, TE; Frey, EA; Grewe, CW; Kebabian, JW | 2 |
| Anthopoulou, H; Covelli, V; Lucchi, L; Spano, PF; Trabucchi, M | 1 |
| Huff, RM; McGonigle, P; Molinoff, PB | 1 |
| Creese, I; Leff, SE; Sibley, DR | 1 |
| Battaglia, G; Shannon, M; Titeler, M | 1 |
| Caron, MG; Kilpatrick, BF | 1 |
| Goldstein, M; Lew, JY | 1 |
| Molinoff, PB; Zahniser, NR | 1 |
| Asano, T; Goldstein, M; Lew, JY; Lieberman, A; Makman, MH; Rosenfeld, MR | 1 |
| Bockaert, J; Marchais, D | 1 |
| Caron, MG; De Lean, A; Kilpatrick, BF | 1 |
| Creese, I; Hamblin, MW | 2 |
| Lazareno, S; Nahorski, SR | 1 |
| Mahler, HR; Near, JA | 1 |
| Nomura, Y; Oki, K | 1 |
| Clement-Cormier, Y; Stafanini, E | 1 |
| Glowinski, J; Hamon, M; Herbet, A; Nelson, DL | 1 |
| Creese, I; Sibley, DR | 1 |
| Ewert, M; Gommeren, W; Leysen, JE; Luyten, WH; Mertens, J; Pauwels, PJ; Seeburg, P | 1 |
| Di Paolo, T; Lévesque, D | 1 |
| Fujiwara, Y; Hamagishi, Y; Hikiji, M; Kashihara, K; Ohnuki, T; Oki, T; Otsuki, S; Roeske, WR; Sora, I; Tomita, H | 1 |
| Horikawa, T; Nomura, Y; Okada, F; Tokumitsu, Y | 1 |
| Castro, SW; Strange, PG | 1 |
| Newman-Tancredi, A; Strange, PG; Sundaram, H | 1 |
| Bischoff, S; Bruinink, A | 1 |
| Coley, C; Daniell, S; Naylor, LH; Strange, PG; Woodward, R | 1 |
| Hoare, SR; Strange, PG | 1 |
| Grünewald, S; Michel, H; Reiländer, H | 1 |
| Chen, LJ; Creese, I; Dong, ZJ; Jin, GZ | 1 |
| Gardner, BR; Hall, DA; Strange, PG | 1 |
| Draguhn, A; Empson, RM; Gloveli, T; Heinemann, U; Schmitz, D | 1 |
| Paul, IA; Weed, MR; Woolverton, WL | 1 |
| Brioni, JD; Chang, R; Cowart, MD; Donnelly-Roberts, DL; Hsieh, GC; Marsh, K; Miller, L; Miller, TR; Moreland, RB; Nakane, M; Namovic, MT; Stewart, AO; Terranova, MA; Uchic, ME; Wetter, JM | 1 |
| Berardi, F; Colabufo, NA; Lacivita, E; Leopoldo, M; Perrone, R | 1 |
2 review(s) available for spiperone and guanosine triphosphate
| Article | Year |
|---|---|
A comprehensive method for the quantitative determination of dopamine receptor subtypes.
Topics: Animals; Binding, Competitive; Corpus Striatum; Dopamine; Dopamine Antagonists; Flupenthixol; GTP-Binding Proteins; Guanosine Triphosphate; Mathematics; Radioligand Assay; Receptors, Cell Surface; Receptors, Dopamine; Receptors, Serotonin; Spiperone; Tritium | 1984 |
Agonist interactions with dopamine receptors: focus on radioligand-binding studies.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cattle; Corpus Striatum; Dopamine; Guanosine Triphosphate; Hydroxydopamines; Pituitary Gland, Anterior; Radioligand Assay; Rats; Receptors, Dopamine; Reserpine; Spiperone | 1984 |
71 other study(ies) available for spiperone and guanosine triphosphate
| Article | Year |
|---|---|
Guanine nucleotides distinguish between two dopamine receptors.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Corpus Striatum; Dopamine; Guanosine Triphosphate; Kainic Acid; Kinetics; Rats; Receptors, Dopamine; Spiperone | 1979 |
Serotonin receptor binding sites affected differentially by guanine nucleotides.
Topics: Animals; Binding, Competitive; Cattle; Cerebral Cortex; Guanine Nucleotides; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Kinetics; Ligands; Lysergic Acid Diethylamide; Male; Mice; Rats; Receptors, Serotonin; Serotonin; Spiperone | 1979 |
Dopamine receptors in human foetal brains: characterization, regulation and ontogeny of [3H]spiperone binding sites in striatum.
Topics: Adult; Binding Sites; Binding, Competitive; Brain; Child, Preschool; Corpus Striatum; Dopamine; Embryonic and Fetal Development; Fetus; Guanosine Triphosphate; Humans; Receptors, Dopamine; Spiperone; Tritium | 1992 |
Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Benzazepines; Blood-Brain Barrier; Corpus Striatum; Dopamine Agents; Guanosine Triphosphate; In Vitro Techniques; Male; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Salicylamides; Spiperone; Stimulation, Chemical; Structure-Activity Relationship | 1990 |
D2 dopamine receptors in calf globus pallidus: agonist high- and low-affinity sites not regulated by guanine nucleotide.
Topics: Animals; Butaclamol; Cattle; Chlorpromazine; Corpus Striatum; Domperidone; Dopamine; Globus Pallidus; Guanosine Triphosphate; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1985 |
A G protein couples serotonin and GABAB receptors to the same channels in hippocampus.
Topics: Animals; Baclofen; Calcium; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Hippocampus; Ion Channels; Phorbol 12,13-Dibutyrate; Phorbol Esters; Potassium; Rats; Receptors, GABA-A; Receptors, Serotonin; Serotonin; Spiperone; Thionucleotides | 1986 |
The interaction between D-2 dopamine receptors and GTP-binding proteins.
Topics: Animals; Binding Sites; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Ion Channels; Pertussis Toxin; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Swine; Thionucleotides; Virulence Factors, Bordetella | 1988 |
Mono- and divalent cations modulate the affinities of brain D1 and D2 receptors for dopamine by a mechanism independent of receptor coupling to guanyl nucleotide binding proteins.
Topics: Animals; Benzazepines; Cations; Corpus Striatum; Dopamine; Dopamine Antagonists; Ethylmaleimide; GTP-Binding Proteins; Guanosine Triphosphate; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1989 |
D2 dopamine receptors in the human brain: heterogeneity based on differences in guanine nucleotide effect on agonist binding, and their presence on corticostriatal nerve terminals.
Topics: Adult; Aged; Aged, 80 and over; Benzazepines; Brain; Cerebral Cortex; Corpus Striatum; Female; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1989 |
Lack of GTP-insensitive D2 dopamine receptors in Huntington's disease.
Topics: Aged; Binding, Competitive; Female; Globus Pallidus; Guanosine Triphosphate; Humans; Huntington Disease; Male; Middle Aged; Putamen; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1989 |
Selective blockade of dopamine D-1 receptor by SCH 23390 affects dopamine agonist binding to 3H-spiperone labeled D-2 receptors in rat striatum.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Binding, Competitive; Corpus Striatum; Dopamine; Dopamine Agents; Ergolines; Guanosine Triphosphate; In Vitro Techniques; Male; Pertussis Toxin; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sodium; Spiperone; Virulence Factors, Bordetella | 1989 |
Properties of rat striatal D-2 dopamine receptors solubilized with the zwitterionic detergent CHAPS.
Topics: Adsorption; Animals; Cholic Acids; Chromatography, Affinity; Chromatography, Gel; Corpus Striatum; Detergents; Female; Guanosine Triphosphate; In Vitro Techniques; Lectins; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sodium; Solubility; Spiperone; Surface-Active Agents; Wheat Germ Agglutinins | 1985 |
Dopaminergic activity of some ergot alkaloid derivatives: relationship to their chemical structure.
Topics: Animals; Cattle; Caudate Nucleus; Dopamine; Ergolines; Ergot Alkaloids; Guanosine Triphosphate; In Vitro Techniques; Molecular Conformation; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Structure-Activity Relationship; Tritium | 1986 |
[3H]spiroxatrine labels a serotonin1A-like site in the rat hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Cell Membrane; Dioxanes; Dioxins; Dopamine; Guanosine Triphosphate; Haloperidol; Hippocampus; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone; Spiro Compounds; Tetrahydronaphthalenes; Tritium | 1987 |
Characterization of D-2 dopamine receptors in a tumor of the rat anterior pituitary gland.
Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Colforsin; Dopamine; Female; Guanosine Triphosphate; Pituitary Gland, Anterior; Pituitary Neoplasms; Rats; Rats, Inbred BUF; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1987 |
Radioreceptor binding reveals the potencies of N,N-disubstituted 2-aminotetralins as D2 dopamine agonists.
Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry; Corpus Striatum; Guanosine Triphosphate; Male; Naphthalenes; Phenethylamines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Tetrahydronaphthalenes; Thiophenes | 1987 |
Ergot alkaloids and central monoaminergic receptors.
Topics: Animals; Antiparkinson Agents; Biogenic Amines; Central Nervous System; Dioxanes; Dopamine; Drug Interactions; Ergot Alkaloids; Guanosine Triphosphate; Humans; Receptors, Adrenergic, alpha; Receptors, Drug; Spiperone; Yohimbine | 1985 |
Purification and characterization of the D2-dopamine receptor from bovine anterior pituitary.
Topics: Affinity Labels; Animals; Cattle; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Molecular Weight; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone; Thionucleotides | 1988 |
Magnesium ions reveal nanomolar potency of dopamine at [3H]spiperone labelled D-2 receptors in rat corpus striatum.
Topics: Animals; Corpus Striatum; Dopamine; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Stimulation, Chemical | 1985 |
Correlation of alpha- and beta-rotameric forms of 2-substituted octahydrobenzo[f]quinoline dopamine congeners with high and low affinity states of the anterior pituitary dopamine receptor and prolactin inhibition.
Topics: Binding, Competitive; Cell Membrane; Dopamine; Guanosine Triphosphate; Molecular Conformation; Motion; Pituitary Gland, Anterior; Prolactin; Receptors, Dopamine; Secretory Rate; Spiperone; Structure-Activity Relationship | 1988 |
Guanyl nucleotide interactions with dopaminergic binding sites labeled by [3H]spiroperidol in human caudate and putamen: guanyl nucleotides enhance ascorbate-induced lipid peroxidation and cause an apparent loss of high affinity binding sites.
Topics: Ascorbic Acid; Caudate Nucleus; Guanosine Triphosphate; Humans; In Vitro Techniques; Inosine Triphosphate; Lipid Peroxides; Putamen; Receptors, Dopamine; Spiperone; Tritium | 1988 |
Estradiol and guanine nucleotide modulation of dopamine receptor agonist and antagonist binding sites in 7315a pituitary tumors.
Topics: Animals; Binding Sites; Estradiol; Female; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Pituitary Neoplasms; Prolactin; Rats; Rats, Inbred BUF; Receptors, Dopamine; Sodium Chloride; Spiperone | 1988 |
Guanine nucleotide effects on agonist binding to serotonin 5HT2 receptors in rat frontal cortex.
Topics: Animals; Cerebral Cortex; Guanine Nucleotides; Guanosine Triphosphate; Ketanserin; Kinetics; Magnesium; Male; Rats; Receptors, Serotonin; Spiperone | 1988 |
Role of assay conditions in determining agonist potency at D2 dopamine receptors in striatal homogenates.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dopamine; Guanosine Triphosphate; Haloperidol; Kinetics; Magnesium; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1986 |
In situ molecular size of agonist dopamine D-2 binding sites in rat striatum.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Guanosine Triphosphate; Kinetics; Male; Molecular Weight; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sodium Chloride; Spiperone | 1987 |
Assay of dopamine receptors with [alpha-3H]flupenthixol.
Topics: Animals; Binding, Competitive; Flupenthixol; Guanosine Triphosphate; Kinetics; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Thioxanthenes | 1985 |
Some in vitro receptor binding properties of [3H]eticlopride, a novel substituted benzamide, selective for dopamine-D2 receptors in the rat brain.
Topics: Animals; Brain; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Salicylamides; Sodium; Spiperone; Sulpiride; Tritium | 1985 |
Altered activity of the inhibitory guanyl nucleotide-binding component (Ni) induced by pertussis toxin. Uncoupling of Ni from receptor with continued coupling of Ni to the catalytic unit.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Bacterial Toxins; Cell Membrane; Cholera Toxin; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Male; Pertussis Toxin; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Virulence Factors, Bordetella | 1984 |
Factors regulating ligand binding to 5-hydroxytryptamine receptors in rat brain.
Topics: Animals; Ascorbic Acid; Bicarbonates; Female; Frontal Lobe; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Lipid Peroxides; Male; Manganese; Oxidation-Reduction; Rats; Receptors, Serotonin; Sodium Bicarbonate; Spiperone | 1984 |
Dopamine receptors, neuroleptics, and schizophrenia.
Topics: Adenylyl Cyclases; Antipsychotic Agents; Apomorphine; Brain; Brain Chemistry; Caudate Nucleus; Dopamine; Guanosine Triphosphate; Haloperidol; Humans; Nucleus Accumbens; Radioligand Assay; Receptors, Dopamine; Schizophrenia; Spiperone | 1981 |
[3H]N-propylapomorphine and [3H]spiperone binding in brain indicate two states of the D2-dopamine receptor.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain; Butyrophenones; Catecholamines; Cattle; Caudate Nucleus; Cyclic AMP; Ergot Alkaloids; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Receptors, Dopamine; Spiperone | 1982 |
Retina contains guanine nucleotide sensitive and insensitive classes of dopamine receptors.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Binding Sites; Butaclamol; Cattle; Corpus Striatum; Guanine Nucleotides; Guanosine Triphosphate; Kinetics; Naphthols; Rats; Receptors, Dopamine; Retina; Spiperone; Tetrahydronaphthalenes | 1980 |
Ontogenetic development of the striatal [3H]spiperone binding: regulation by sodium and guanine nucleotide in rats.
Topics: Aging; Animals; Animals, Newborn; Butaclamol; Butyrophenones; Corpus Striatum; Female; Guanosine Triphosphate; Kinetics; Male; Rats; Rats, Inbred Strains; Sodium; Spiperone; Synaptic Membranes | 1982 |
Correspondency between different affinity states and target size of the bovine striatal D2 dopamine receptor.
Topics: Acetylcholinesterase; Animals; Apomorphine; Butaclamol; Cattle; Cell Membrane; Corpus Striatum; Dopamine; Guanosine Triphosphate; Kinetics; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Sulpiride | 1983 |
Selective decrease in the affinity of D2 dopamine receptor for agonist induced by islet-activating protein, pertussis toxin, associated with ADP-ribosylation of the specific membrane protein of bovine striatum.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Bacterial Proteins; Bacterial Toxins; Binding, Competitive; Cattle; Corpus Striatum; Electrophoresis, Polyacrylamide Gel; Guanosine Triphosphate; Hypoglycemic Agents; Kinetics; Membrane Proteins; Molecular Weight; Nucleoside Diphosphate Sugars; Pertussis Toxin; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Synaptic Membranes; Virulence Factors, Bordetella | 1983 |
Molecular regulatory mechanism of D2 dopamine receptor in the bovine striatum.
Topics: Acetylcholinesterase; Adenosine Diphosphate Ribose; Animals; Bacterial Toxins; Cattle; Corpus Striatum; GTP-Binding Proteins; Guanosine Triphosphate; In Vitro Techniques; Models, Biological; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Virulence Factors, Bordetella | 1984 |
Evidence that the D-2 dopamine receptor in the intermediate lobe of the rat pituitary gland is associated with an inhibitory guanyl nucleotide component.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Cholera Toxin; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Isoproterenol; Pituitary Gland; Rats; Receptors, Adrenergic, beta; Receptors, Dopamine; Spiperone | 1983 |
Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum.
Topics: Adenylyl Cyclases; Alcohol Drinking; Animals; Apomorphine; Corpus Striatum; Cyclic AMP; Dopamine; Ethanol; Guanosine Triphosphate; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Synaptic Membranes; Synaptic Transmission | 1983 |
Guanine nucleotides modulate cortical S2 serotonin receptors.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; In Vitro Techniques; Ketanserin; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone | 1984 |
Agonist binding promotes a guanine nucleotide reversible increase in the apparent size of the bovine anterior pituitary dopamine receptors.
Topics: Animals; Binding, Competitive; Cattle; Cell Membrane; Chromatography, High Pressure Liquid; Dopamine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Molecular Weight; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone | 1983 |
Solubilization and characterization of striatal dopamine receptors.
Topics: Animals; Binding, Competitive; Cattle; Cell Membrane; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine Antagonists; Guanosine Triphosphate; Rats; Receptors, Dopamine; Solubility; Spiperone | 1984 |
Properties of dopamine agonist and antagonist binding sites in mammalian retina.
Topics: Adenosine Triphosphate; Animals; Binding, Competitive; Butyrophenones; Cattle; Dopamine; Guanosine Triphosphate; Haplorhini; Lysergic Acid Diethylamide; Macaca mulatta; Naphthalenes; Rabbits; Rats; Receptors, Dopamine; Retina; Spiperone; Stereoisomerism; Tetrahydronaphthalenes | 1980 |
Thermodynamic differences between agonist and antagonist interactions with binding sites for [3H]spiroperidol in rat striatum.
Topics: Animals; Ascorbic Acid; Binding Sites; Butyrophenones; Corpus Striatum; Dopamine; Guanosine Triphosphate; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Thermodynamics; Time Factors | 1983 |
Interaction of pergolide with central dopaminergic receptors.
Topics: Adenylyl Cyclases; Animals; Behavior, Animal; Binding, Competitive; Cattle; Cerebral Decortication; Chlorocebus aethiops; Corpus Striatum; Ergolines; Guanosine Triphosphate; Hot Temperature; Male; Pergolide; Rats; Receptors, Dopamine; Spiperone; Tegmentum Mesencephali; Tremor | 1980 |
Is there a connection between high affinity 3H-spiperone binding sites and DA-sensitive adenylate cyclase in corpus striatum?
Topics: Adenylyl Cyclases; Animals; Binding Sites; Butyrophenones; Corpus Striatum; Dopamine; Guanosine Triphosphate; Haloperidol; In Vitro Techniques; Male; Phenethylamines; Phenoxybenzamine; Rats; Spiperone | 1980 |
Guanine nucleotides regulate both dopaminergic agonist and antagonist binding in porcine anterior pituitary.
Topics: Animals; Apomorphine; Binding, Competitive; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone; Swine | 1982 |
[3H]spiroperidol identifies a D-2 dopamine receptor inhibiting adenylate cyclase activity in the intermediate lobe of the rat pituitary gland.
Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Binding, Competitive; Butyrophenones; Cholera Toxin; Fluphenazine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Male; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Sulpiride | 1982 |
3H-dopamine binding to rat striatal D-2 and D-3 sites: enhancement by magnesium and inhibition by guanine nucleotides and sodium.
Topics: Animals; Binding Sites; Binding, Competitive; Corpus Striatum; Domperidone; Dopamine; Guanosine Triphosphate; Magnesium; Rats; Sodium; Spiperone | 1982 |
Selective labelling of dopamine (D2) receptors in rat striatum by [3H]domperidone but not by [3H]spiperone.
Topics: Animals; Binding Sites; Butyrophenones; Corpus Striatum; Domperidone; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin; Spiperone; Sulpiride; Tritium | 1982 |
Guanine nucleotides do not inhibit tritiated dopamine agonist binding to bovine striatal membranes.
Topics: Animals; Apomorphine; Binding, Competitive; Butyrophenones; Cattle; Caudate Nucleus; Corpus Striatum; Dopamine; Guanosine Triphosphate; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes | 1982 |
Heat treatment mimics guanosine-5'-triphosphate effects on dopaminergic 3H-ligand binding to bovine caudate membranes.
Topics: Animals; Apomorphine; Cattle; Caudate Nucleus; Guanine Nucleotides; Guanosine Triphosphate; Hot Temperature; In Vitro Techniques; Membranes; Receptors, Dopamine; Spiperone | 1982 |
Development of inhibitory activity of sulpiride for synaptic [3H]-spiperone binding in the rat striatum.
Topics: Aging; Animals; Binding, Competitive; Butyrophenones; Corpus Striatum; Female; Guanosine Triphosphate; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sodium; Spiperone; Sulpiride; Synapses | 1982 |
Detection of dopamine receptors in the area postrema.
Topics: Adenylyl Cyclases; Animals; Cerebral Ventricles; Dogs; Emetics; Female; Guanosine Triphosphate; Male; Receptors, Dopamine; Spiperone; Tritium | 1981 |
Multiple receptors for serotonin in the rat brain.
Topics: Adenylyl Cyclases; Animals; Brain; Butyrophenones; Cerebral Cortex; Corpus Striatum; Enzyme Activation; Guanosine Triphosphate; Hippocampus; Rats; Receptors, Serotonin; Serotonin; Spiperone; Synaptic Membranes | 1980 |
Dopamine receptor binding in bovine intermediate lobe pituitary membranes.
Topics: Animals; Apomorphine; Butyrophenones; Catecholamines; Cattle; Cell Membrane; Guanosine Triphosphate; Phenothiazines; Pituitary Gland; Receptors, Dopamine; Spiperone | 1980 |
Comparison of in vitro binding properties of a series of dopamine antagonists and agonists for cloned human dopamine D2S and D2L receptors and for D2 receptors in rat striatal and mesolimbic tissues, using [125I] 2'-iodospiperone.
Topics: Animals; Cloning, Molecular; Dopamine Agonists; Dopamine Antagonists; Female; Guanosine Triphosphate; Humans; Iodine Radioisotopes; Ligands; Limbic System; Neostriatum; Nucleus Accumbens; Olfactory Bulb; Pituitary Gland; Rats; Rats, Wistar; Receptors, Dopamine D2; Spiperone | 1993 |
Modulation by estradiol and progesterone of the GTP effect on striatal D-2 dopamine receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dopamine; Dopamine Agents; Estradiol; Female; Guanosine Triphosphate; In Vitro Techniques; Male; Ovariectomy; Progesterone; Rats; Receptors, Dopamine D2; Spiperone | 1993 |
Characterization of a cloned rat serotonin 5-HT1A receptor expressed in the HeLa cell line.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Binding, Competitive; Cloning, Molecular; Guanosine Triphosphate; HeLa Cells; Humans; Rats; Receptors, Serotonin; Serotonin Receptor Agonists; Spiperone; Transfection | 1993 |
Chronic desipramine treatment influences D1 stimulation and D2 inhibition (dual control) of adenylate cyclase by dopamine in rat striatum.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Benzazepines; Carbachol; Corpus Striatum; Desipramine; Dopamine; Guanosine Triphosphate; Male; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone | 1994 |
Coupling of D2 and D3 dopamine receptors to G-proteins.
Topics: Animals; Binding, Competitive; Cell Line; CHO Cells; Cricetinae; GTP-Binding Proteins; Guanosine Triphosphate; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Spiperone | 1993 |
Characterization of recombinant human serotonin 5HT1A receptors expressed in Chinese hamster ovary cells. [3H]spiperone discriminates between the G-protein-coupled and -uncoupled forms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; CHO Cells; Cricetinae; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Radioligand Assay; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Spiperone; Tritium | 1993 |
Dopamine D2 receptors are unevenly distributed in the rat hippocampus and are modulated differently than in striatum.
Topics: Animals; Corpus Striatum; Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Iron Chelating Agents; Magnesium; Male; Phenanthrolines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine D2; Spiperone | 1993 |
Investigation of the role of conserved serine residues in the long form of the rat D2 dopamine receptor using site-directed mutagenesis.
Topics: Alanine; Allosteric Regulation; Animals; Cell Line, Transformed; Chlorocebus aethiops; Dopamine Agonists; Dopamine Antagonists; GTP-Binding Proteins; Guanosine Triphosphate; Hydrogen Bonding; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, Dopamine D2; Serine; Spiperone; Structure-Activity Relationship; Transfection | 1996 |
Regulation of D2 dopamine receptors by amiloride and amiloride analogs.
Topics: Amiloride; Animals; Binding Sites; Binding, Competitive; Diuretics; Guanosine Triphosphate; Kinetics; Magnesium Chloride; Radioligand Assay; Rats; Receptors, Dopamine D2; Sodium-Hydrogen Exchangers; Spiperone; Tritium | 1996 |
In vivo reconstitution of dopamine D2S receptor-mediated G protein activation in baculovirus-infected insect cells: preferred coupling to Gi1 versus Gi2.
Topics: Adenosine Triphosphate; Animals; Apomorphine; Baculoviridae; Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Dopamine Agonists; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Receptors, Dopamine D2; Spiperone; Spodoptera | 1996 |
GTP regulation of (-)-stepholidine binding to R(H) of D1 dopamine receptors in calf striatum.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Benzazepines; Berberine; Binding, Competitive; Cattle; Corpus Striatum; Guanosine Triphosphate; Male; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Rotation; Spiperone | 1997 |
Agonist action at D2(short) dopamine receptors determined in ligand binding and functional assays.
Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Dopamine Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Ligands; Receptors, Dopamine D2; Spiperone | 1997 |
Serotonin reduces synaptic excitation in the superficial medial entorhinal cortex of the rat via a presynaptic mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bicuculline; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Female; Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Male; Patch-Clamp Techniques; Piperazines; Potassium Channels; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Synapses; Synaptic Transmission; Tetrodotoxin | 1998 |
Dopamine D1 and D2 receptor selectivities of phenyl-benzazepines in rhesus monkey striata.
Topics: Animals; Benzazepines; Binding, Competitive; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Female; Guanosine Triphosphate; In Vitro Techniques; Macaca mulatta; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Tritium | 1998 |
2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.
Topics: Animals; Benzamides; Benzimidazoles; Binding, Competitive; Calcium; Cell Line; Clozapine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Europium; Fluorometry; GABA Antagonists; Guanosine Triphosphate; Humans; Male; Penile Erection; Piperazines; Pyridines; Pyrroles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spiperone; Time Factors; Tritium | 2005 |
Synthesis and binding profile of constrained analogues of N-[4-(4-arylpiperazin-1-yl)butyl]-3-methoxybenzamides, a class of potent dopamine D3 receptor ligands.
Topics: Animals; Benzamides; Binding, Competitive; Cell Line; Cerebral Cortex; CHO Cells; Cricetinae; Cricetulus; Guanosine Triphosphate; Hippocampus; Humans; In Vitro Techniques; Ligands; Male; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D3; Spiperone | 2006 |