spiperone has been researched along with guanosine 5'-o-(3-thiotriphosphate) in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.57) | 18.7374 |
| 1990's | 14 (40.00) | 18.2507 |
| 2000's | 16 (45.71) | 29.6817 |
| 2010's | 2 (5.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elazar, Z; Fuchs, S | 1 |
| Andrade, R; Malenka, RC; Nicoll, RA | 1 |
| Berstein, G; Haga, K; Haga, T; Ichiyama, A; Ohara, K | 1 |
| Amlaiky, N; Caron, MG; Falardeau, P; Senogles, SE | 1 |
| Gardner, B; Strange, PG | 1 |
| Graber, SG; Rooney, BC; Strange, PG; Woodcock, C | 1 |
| Bernard, A; Cavegn, C; Chabert, C; Mills, A | 1 |
| Allet, B; Bernard, A; Brandt, E; Cavegn, C; Chabert, C; Chollet, A; Kawashima, E; Mills, A | 1 |
| Hery, F; Pesce, G | 1 |
| Grünewald, S; Michel, H; Reiländer, H | 1 |
| Chaput, C; Conte, C; Millan, MJ; Newman-Tancredi, A; Spedding, M | 1 |
| Audinot, V; Chaput, C; Millan, MJ; Newman-Tancredi, A; Verrièle, L | 1 |
| Gardner, BR; Hall, DA; Strange, PG | 1 |
| Barr, AJ; Manning, DR | 1 |
| Alper, RH; Nelson, DL | 1 |
| Conklin, DS; Fitzgerald, LW; Hartig, PR; Iyer, G; Kostich, WA; Krause, CM; Largent, BL; Marshall, AP; Patterson, JP; Tran, DP | 1 |
| Geurts, M; Hermans, E; Maloteaux, JM | 1 |
| Ferré, S; Finnman, UB; Fuxe, K; Owman, C; Rinken, A; Terasmaa, A | 1 |
| Kumar, U; Lange, DC; Patel, RC; Patel, SC; Patel, YC; Rocheville, M | 1 |
| Alper, RH; Gilliland, SL; Levant, B | 1 |
| Croskery, K; Feuerbach, D; Gazi, L; Hoyer, D; Nunn, C; Schoeffter, P | 1 |
| Armstrong, D; Coldwell, MC; Hoare, SR; Strange, PG | 1 |
| Collin, L; Ho, M; Price, GW; Riley, G; Scott, C; Selkirk, JV; Watson, J | 1 |
| Cosi, C; Koek, W | 1 |
| Cordeaux, Y; Flood, LA; Graber, SG; Nickolls, SA; Strange, PG | 1 |
| Bridges, SR; Thompson, TL; Weirs, WJ | 1 |
| Nickolls, SA; Strange, PG | 2 |
| Hermans, E; Maloteaux, JM; Peeters, M | 1 |
| Gazi, L; Lopéz-Giménez, JF; Pauwels, PJ; Strange, PG; Wurch, T | 1 |
| Lin, H; Roberts, DJ; Strange, PG | 1 |
| Childers, SR; Davies, HM; Gregg, TC; O'Connor, KA | 1 |
| Cha, MY; Cho, H; Choi, KI; Jeong, D; Koh, HY; Kong, JY; Lee, SJ; Pae, AN; Park, WK | 1 |
| Antonio, T; Dutta, AK; Gopishetty, B; Kharkar, PS; Reith, M; Zhang, S | 1 |
| Ali, S; Antonio, T; Dutta, AK; Neve, KA; Reith, ME; Zhen, J | 1 |
35 other study(ies) available for spiperone and guanosine 5'-o-(3-thiotriphosphate)
| Article | Year |
|---|---|
Vanadate inhibits agonist binding to D2 dopamine receptor.
Topics: Animals; Apomorphine; Binding, Competitive; Cattle; Cell Membrane; Corpus Striatum; Dopamine Agents; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Kinetics; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Vanadates | 1991 |
A G protein couples serotonin and GABAB receptors to the same channels in hippocampus.
Topics: Animals; Baclofen; Calcium; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Hippocampus; Ion Channels; Phorbol 12,13-Dibutyrate; Phorbol Esters; Potassium; Rats; Receptors, GABA-A; Receptors, Serotonin; Serotonin; Spiperone; Thionucleotides | 1986 |
The interaction between D-2 dopamine receptors and GTP-binding proteins.
Topics: Animals; Binding Sites; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Ion Channels; Pertussis Toxin; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Swine; Thionucleotides; Virulence Factors, Bordetella | 1988 |
Purification and characterization of the D2-dopamine receptor from bovine anterior pituitary.
Topics: Affinity Labels; Animals; Cattle; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Molecular Weight; Pituitary Gland, Anterior; Receptors, Dopamine; Spiperone; Thionucleotides | 1988 |
Pharmacological characterisation of high affinity [35S]GTP gamma S binding in membranes from CHO-K1 cells stably expressing rat D2(short) dopamine receptors.
Topics: Animals; Butaclamol; Cell Membrane; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Kinetics; Rats; Receptors, Dopamine D2; Recombinant Proteins; Spiperone; Stereoisomerism; Sulfur Radioisotopes | 1995 |
Expression of the rat D2 and D3 dopamine receptors in insect cells using the baculovirus system.
Topics: Animals; Baculoviridae; Cell Line; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Proteins; Spiperone; Spodoptera; Time Factors; Transfection | 1995 |
Characterization of the functional activity of dopamine ligands at human recombinant dopamine D4 receptors.
Topics: Animals; Cell Line; Clozapine; DNA; Dopamine; Dopamine Agents; Ergolines; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Ligands; Moths; Quinpirole; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone; Sulfur Radioisotopes; Tritium | 1994 |
Expression and characterization of human D4 dopamine receptors in baculovirus-infected insect cells.
Topics: Animals; Baculoviridae; Base Sequence; Cell Line; Ergolines; Genetic Vectors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Introns; Molecular Sequence Data; Moths; Occlusion Body Matrix Proteins; Quinpirole; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Fusion Proteins; Spiperone; Viral Proteins; Viral Structural Proteins | 1993 |
Resolution of multiple affinity states of 5-hydroxytryptamine-1A receptors labelled by [3H]-8-hydroxy-2-(di-n-propilamino) tetralin in rat hippocampal membranes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Dopamine Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; In Vitro Techniques; Membranes; Rats; Receptors, Serotonin; Serotonin Receptor Agonists; Spiperone; Thermodynamics | 1996 |
In vivo reconstitution of dopamine D2S receptor-mediated G protein activation in baculovirus-infected insect cells: preferred coupling to Gi1 versus Gi2.
Topics: Adenosine Triphosphate; Animals; Apomorphine; Baculoviridae; Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Dopamine Agonists; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Receptors, Dopamine D2; Spiperone; Spodoptera | 1996 |
Inhibition of the constitutive activity of human 5-HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635.
Topics: Animals; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Piperazines; Pyridines; Radioligand Assay; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Recombinant Proteins; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Sulfur Radioisotopes | 1997 |
[35S]Guanosine-5'-O-(3-thio)triphosphate binding as a measure of efficacy at human recombinant dopamine D4.4 receptors: actions of antiparkinsonian and antipsychotic agents.
Topics: Animals; Antiparkinson Agents; Antipsychotic Agents; Binding, Competitive; CHO Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Magnesium Chloride; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Sodium Chloride; Spiperone | 1997 |
Agonist action at D2(short) dopamine receptors determined in ligand binding and functional assays.
Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Dopamine Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Ligands; Receptors, Dopamine D2; Spiperone | 1997 |
Agonist-independent activation of Gz by the 5-hydroxytryptamine1A receptor co-expressed in Spodoptera frugiperda cells. Distinguishing inverse agonists from neutral antagonists.
Topics: Aminopyridines; Animals; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; Kinetics; Ligands; Piperazines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Spiperone; Spodoptera; Tetrahydronaphthalenes | 1997 |
Characterization of 5-HT1A receptor-mediated [35S]GTPgammaS binding in rat hippocampal membranes.
Topics: Animals; Cell Membrane; Frontal Lobe; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hippocampus; Kinetics; Male; Methiothepin; Piperazines; Protein Binding; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Sulfur Radioisotopes; Temperature | 1998 |
High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.
Topics: Amphetamines; Binding, Competitive; Cell Line; Ergolines; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrolysis; Isomerism; Ligands; Models, Biological; Phosphatidylinositols; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone | 1999 |
Enhanced striatal dopamine D(2) receptor-induced [35S]GTPgammaS binding after haloperidol treatment.
Topics: Animals; Apomorphine; Binding, Competitive; Catalepsy; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Spiperone; Sulfur Radioisotopes; Tritium; Up-Regulation | 1999 |
Modulation of [(35)S]GTPgammaS binding to chinese hamster ovary cell membranes by D(2(short)) dopamine receptors.
Topics: Animals; Binding, Competitive; Butaclamol; CHO Cells; Cricetinae; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Membranes; Raclopride; Radioligand Assay; Rats; Receptors, Dopamine D2; Spiperone; Sulfur Radioisotopes; Tritium | 2000 |
Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity.
Topics: Animals; Cell Membrane; Cerebral Cortex; CHO Cells; Colforsin; Corpus Striatum; Cricetinae; Cyclic AMP; Dimerization; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; Ligands; Male; Neurons; Pyramidal Cells; Quinpirole; Rats; Receptor Cross-Talk; Receptors, Dopamine D2; Receptors, Somatostatin; Somatostatin; Spiperone; Sulpiride; Transfection | 2000 |
Pharmacology of quinpirole-stimulated [35S]GTPgammaS binding: discrepancy with receptor binding profile.
Topics: Animals; Benzazepines; Binding, Competitive; Clorgyline; Clozapine; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Membranes; Monoamine Oxidase Inhibitors; Quinpirole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Selegiline; Spiperone; Sulfur Radioisotopes; Thiazoles | 2000 |
Cloning, expression, functional coupling and pharmacological characterization of the rat dopamine D4 receptor.
Topics: Animals; Binding, Competitive; Calcium; Cells, Cultured; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; DNA-Binding Proteins; DNA, Complementary; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Nuclear Proteins; Pertussis Toxin; Rats; Receptors, Dopamine D2; Receptors, Dopamine D4; Serum Response Factor; Spiperone; Sulfur Radioisotopes; Transfection; Tritium; Virulence Factors, Bordetella | 2000 |
Regulation of human D(1), d(2(long)), d(2(short)), D(3) and D(4) dopamine receptors by amiloride and amiloride analogues.
Topics: Allosteric Regulation; Amiloride; Animals; Benzazepines; Cell Line; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Spiperone | 2000 |
5-HT(1A) receptor agonist-antagonist binding affinity difference as a measure of intrinsic activity in recombinant and native tissue systems.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone | 2000 |
The putative <
Topics: Binding, Competitive; Cell Membrane; DNA, Recombinant; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Piperazines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sodium Chloride; Spiperone; Sulfur Radioisotopes | 2000 |
Agonist regulation of D(2) dopamine receptor/G protein interaction. Evidence for agonist selection of G protein subtype.
Topics: Animals; Baculoviridae; Binding, Competitive; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Kinetics; Radioligand Assay; Rats; Receptors, Dopamine D2; Recombinant Proteins; Spiperone; Spodoptera; Sulfur Radioisotopes; Transfection; Tritium | 2001 |
Alteration of dopamine transport in the striatum and nucleus accumbens of ovariectomized and estrogen-primed rats following N-(p-isothiocyanatophenethyl) spiperone (NIPS) treatment.
Topics: Animals; Carrier Proteins; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Plasma Membrane Transport Proteins; Drug Interactions; Estrogens; Estrus; Female; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Nucleus Accumbens; Ovariectomy; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Spiperone; Sulfur Radioisotopes; Synaptosomes; Tritium | 2001 |
Interaction of the D2short dopamine receptor with G proteins: analysis of receptor/G protein selectivity.
Topics: Animals; Apomorphine; Binding Sites; Cells, Cultured; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Dopamine D2; Spiperone; Spodoptera; Sulfur Radioisotopes; Suramin; Tritium | 2003 |
Distinct effects of amantadine and memantine on dopaminergic transmission in the rat striatum.
Topics: Amantadine; Animals; Benzazepines; Carbachol; Dopamine; Dopamine Agents; Dopamine Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Memantine; Membranes; Muscarinic Agonists; Neostriatum; Rats; Rats, Wistar; Spiperone; Synaptic Transmission; Synaptosomes | 2003 |
Pharmacological analysis of a dopamine D(2Short):G(alphao) fusion protein expressed in Sf9 cells.
Topics: Animals; Apomorphine; Baculoviridae; Binding Sites; Binding, Competitive; Cell Line; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Receptors, Dopamine D2; Recombinant Fusion Proteins; Spiperone; Spodoptera | 2003 |
Investigation of the mechanism of agonist and inverse agonist action at D2 dopamine receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Butaclamol; CHO Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Receptors, Dopamine D2; Spiperone; Sulfur Radioisotopes; Tritium | 2004 |
The influence of G protein subtype on agonist action at D2 dopamine receptors.
Topics: Animals; Baculoviridae; Binding, Competitive; Cell Membrane; Dopamine Agonists; Dopamine Antagonists; Epitopes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Polymorphism, Genetic; Receptors, Dopamine D2; Receptors, G-Protein-Coupled; Spiperone; Spodoptera | 2004 |
Effects of long-term biogenic amine transporter blockade on receptor/G-protein coupling in rat brain.
Topics: Animals; Apomorphine; Biogenic Monoamines; Brain; Cocaine; Dopamine Antagonists; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Isotopes; Male; Membrane Transport Modulators; Membrane Transport Proteins; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Spiperone; Time | 2005 |
KKHA-761, a potent D3 receptor antagonist with high 5-HT1A receptor affinity, exhibits antipsychotic properties in animal models of schizophrenia.
Topics: Animals; Antipsychotic Agents; Body Temperature; Catalepsy; Cell Line; Dopamine Uptake Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ion Channels; Isoxazoles; Male; Mice; Mice, Inbred ICR; Piperazines; Postural Balance; Prolactin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D1; Receptors, Dopamine D3; Receptors, Dopamine D4; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Serotonin Receptor Agonists; Spiperone; Swimming | 2005 |
Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors.
Topics: Animals; CHO Cells; Cricetulus; Dopamine Agonists; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Kinetics; Naphthalenes; Piperazines; Protein Binding; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D3; Spiperone; Structure-Activity Relationship | 2013 |
Use of radiolabeled antagonist assays for assessing agonism at D2 and D3 dopamine receptors: comparison with functional GTPγS assays.
Topics: Animals; CHO Cells; Cricetulus; Dopamine Agonists; Drug Evaluation, Preclinical; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Receptors, Dopamine D2; Receptors, Dopamine D3; Spiperone; Sulfur Radioisotopes; Transfection; Tritium | 2015 |