Page last updated: 2024-08-16

spiperone and cyproheptadine

spiperone has been researched along with cyproheptadine in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199015 (60.00)18.7374
1990's6 (24.00)18.2507
2000's3 (12.00)29.6817
2010's1 (4.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Andrews, PR; Craik, DJ; Martin, JL1
Anderson, PS; Atkinson, JG; Bélanger, P; Britcher, SF; Fuentes, JJ; Girard, Y; Hunt, CA; King, SW; Randall, WC; Remy, DC; Risley, EA; Robinson, JL; Rooney, CS; Totaro, JA; Williams, M1
Adham, N; Bard, JA; Branchek, TA; Vaysse, P; Weinshank, RL; Zgombick, J1
Arrang, JM; Diaz, J; Leurs, R; Ruat, M; Schwartz, JC; Tardivel-Lacombe, J; Traiffort, E1
Benhamú, B; Lavandera, JL; López-Rodríguez, ML; Morcillo, MJ; Porras, E; Ramos, JA1
Itoh, H; Muramatsu, I; Taniguchi, T; Yoshio, R1
Benhamú, B; Campillo, M; Lavandera, JL; López-Rodríguez, ML; Morcillo, MJ; Olivella, M; Pardo, L; Porras, E; Ramos, JA; Soto, LJ1
Lepailleur, A; Rochais, C; Thirumaran, SL1
Anand, N; Humber, L; Jain, PC; Jílek, J; Philipp, A; Protiva, M; Saxena, AK; Seeman, P; Westman, K1
Boggan, WO; Buckholtz, NS; Meyer, JS1
Fuller, RW; Snoddy, HD1
Klimek, V; Maj, J; Rawlów, A; Sarnek, J1
Ido, T; Iwata, R; Pascali, C; Takahashi, T; Yanai, K; Yuasa, M1
Deshpande, SB; Warnick, JE1
Fermanian, J; Frances, H; Lienard, C1
Brauner, V; Kalkman, HO; Neumann, V1
De Clerck, F; Janssen, PA; Tollenaere, JP; Xhonneux, B1
Klimek, V; Nielsen, M1
Manda, T; Mori, J; Nishigaki, F; Shimomura, K1
Brunello, N; Monopoli, A; Ongini, E; Racagni, G; Rovescalli, AC1
Coppings, RJ; Giachetti, A; Krulich, L; Mayfield, MA; McCann, SM1
Freedman, M; Hamel, L; Luttinger, D; Perrone, M; Ward, SJ1
Blackshear, MA; Friedman, RL; Sanders-Bush, E1
Braghiroli, L; De Feo, G; Giacomelli, S; Koppenaal, DW; Ponzianelli, A1

Reviews

1 review(s) available for spiperone and cyproheptadine

ArticleYear
Structure-activity relationships of serotonin 5-HT
    European journal of medicinal chemistry, 2019, Dec-01, Volume: 183

    Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship

2019

Other Studies

24 other study(ies) available for spiperone and cyproheptadine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:7

    Topics: Animals; Antipsychotic Agents; Benzazepines; Binding, Competitive; Biological Assay; Brain; Cell Membrane; Piperidines; Receptors, Cell Surface; Structure-Activity Relationship

1983
Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.
    The Journal of biological chemistry, 1993, Nov-05, Volume: 268, Issue:31

    Topics: Adenylyl Cyclases; Base Sequence; Cloning, Molecular; DNA Primers; Humans; Molecular Sequence Data; Receptors, Serotonin; Sequence Alignment; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction

1993
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Sep-15, Volume: 90, Issue:18

    Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; CHO Cells; Cricetinae; Cyclic AMP; DNA; Genomic Library; Kinetics; Lysergic Acid Diethylamide; Mianserin; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; Organ Specificity; Rats; Receptors, Serotonin; Restriction Mapping; Serotonin; Serotonin Receptor Agonists; Transfection

1993
First pharmacophoric hypothesis for 5-HT7 antagonism.
    Bioorganic & medicinal chemistry letters, 2000, May-15, Volume: 10, Issue:10

    Topics: Animals; Cell Membrane; Drug Design; Drug Evaluation, Preclinical; Hypothalamus; Models, Molecular; Rats; Receptors, Serotonin; Reproducibility of Results; Serotonin Antagonists; Structure-Activity Relationship

2000
Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes.
    Japanese journal of pharmacology, 2001, Volume: 86, Issue:2

    Topics: Animals; Aorta, Thoracic; Carotid Arteries; Dogs; Humans; Male; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Serotonin Antagonists; Serotonin Receptor Agonists

2001
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.
    Journal of medicinal chemistry, 2003, Dec-18, Volume: 46, Issue:26

    Topics: Animals; Binding, Competitive; Computer Simulation; Drug Design; Hypothalamus; In Vitro Techniques; Lactams; Ligands; Male; Models, Molecular; Molecular Conformation; Naphthalenes; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides; Thiazoles

2003
Neuroleptic receptors: stereoselectivity for neuroleptic enantiomers.
    European journal of pharmacology, 1979, Jun-15, Volume: 56, Issue:3

    Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Butaclamol; Cattle; Caudate Nucleus; Cyproheptadine; Dibenzocycloheptenes; Dibenzothiepins; Isomerism; Isoquinolines; Receptors, Drug; Spiperone; Stereoisomerism

1979
Serotonergic stimulation of pituitary-adrenal activity in the mouse.
    Neuroendocrinology, 1978, Volume: 26, Issue:5

    Topics: 5-Hydroxytryptophan; Animals; Atropine; Benserazide; Carbidopa; Carbolines; Corticosterone; Cyproheptadine; Female; Fenclonine; Indoles; Metergoline; Mice; Pargyline; Phenyl Ethers; Pituitary-Adrenal System; Propylamines; Quinolines; Quipazine; Spiperone; Tryptophan

1978
The effects of metergoline and other serotonin receptor antagonists on serum corticosterone in rats.
    Endocrinology, 1979, Volume: 105, Issue:4

    Topics: Animals; Corticosterone; Cyproheptadine; Ergolines; Male; Metergoline; Methysergide; Rats; Serotonin Antagonists; Spiperone; Structure-Activity Relationship

1979
On the anticataleptic action of cyproheptadine.
    Pharmacology, biochemistry, and behavior, 1976, Volume: 5, Issue:2

    Topics: Animals; Atropine; Catalepsy; Clomipramine; Cyproheptadine; Desipramine; Female; Fluphenazine; Humans; Imipramine; Male; Methyltyrosines; Pilocarpine; Pimozide; Promethazine; Rats; Reserpine; Spiperone

1976
On-line [11C]methylation using [11C]methyl iodide for the automated preparation of 11C-radiopharmaceuticals.
    International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 1992, Volume: 43, Issue:9

    Topics: Benztropine; Carbon Radioisotopes; Cyproheptadine; Doxepin; Hydrocarbons, Iodinated; Isotope Labeling; Methylation; Spiperone

1992
Interaction of thyrotropin-releasing hormone and methysergide on the monosynaptic reflex in isolated mammalian spinal cord.
    Neuroscience letters, 1990, Aug-14, Volume: 116, Issue:1-2

    Topics: 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Cyproheptadine; Drug Interactions; In Vitro Techniques; Indoles; Ketanserin; Male; Methysergide; Rats; Rats, Inbred Strains; Reflex; Serotonin Antagonists; Spinal Cord; Spiperone; Synapses; Thyrotropin-Releasing Hormone; Tropisetron

1990
Improvement of the isolation-induced social behavioural deficit involves activation of the 5-HT1B receptors.
    Progress in neuro-psychopharmacology & biological psychiatry, 1990, Volume: 14, Issue:1

    Topics: Animals; Cyproheptadine; Escape Reaction; Indoles; Male; Mianserin; Mice; Mice, Inbred Strains; Penbutolol; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Social Behavior; Social Isolation; Spiperone; Tropisetron

1990
Supersensitivity of atherosclerotic rabbit aorta to ergometrine is mediated by 5-HT2 receptors.
    The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:12

    Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Body Weight; Cyproheptadine; Ergonovine; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Rabbits; Receptors, Serotonin; Spiperone

1989
Dependence of the antagonism at human platelet 5-HT2 receptors by ketanserin on the reaction pH.
    Thrombosis research, 1985, Dec-01, Volume: 40, Issue:5

    Topics: Amidines; Blood Platelets; Butyrophenones; Cyproheptadine; Female; Humans; Hydrogen-Ion Concentration; Ketanserin; Kinetics; Male; Piperidines; Platelet Aggregation; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone

1985
Chronic treatment with antidepressants decreases the number of [3H]SCH 23390 binding sites in the rat striatum and limbic system.
    European journal of pharmacology, 1987, Jul-09, Volume: 139, Issue:2

    Topics: Animals; Antidepressive Agents; Benzazepines; Benztropine; Corpus Striatum; Cyproheptadine; In Vitro Techniques; Limbic System; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Drug; Spiperone

1987
Important role of serotonin in the antitumor effects of recombinant human tumor necrosis factor-alpha in mice.
    Cancer research, 1988, Aug-01, Volume: 48, Issue:15

    Topics: Animals; Cell Survival; Cyproheptadine; Female; Fibrosarcoma; Ketanserin; Mice; Mice, Inbred BALB C; Receptors, Serotonin; Recombinant Proteins; Serotonin; Serotonin Antagonists; Spiperone; Tumor Necrosis Factor-alpha

1988
Absence of [3H]SCH 23390 specific binding sites in anterior pituitary: dissociation from effects on prolactin secretion.
    European journal of pharmacology, 1987, Mar-17, Volume: 135, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Binding Sites; Corpus Striatum; Cyproheptadine; Ergolines; Kinetics; Male; Metergoline; Pituitary Gland, Anterior; Prolactin; Quinpirole; Rats; Rats, Inbred Strains; Spiperone

1987
Lack of evidence that the central serotoninergic system plays a role in the activation of prolactin secretion following inhibition of dopamine synthesis or blockade of dopamine receptors in the male rat.
    Neuroendocrinology, 1980, Volume: 30, Issue:3

    Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Cyproheptadine; Depression, Chemical; Dopamine; Dopamine Antagonists; Fenclonine; Fluoxetine; Flupenthixol; Hypothalamus; Male; Methysergide; Prolactin; Rats; Receptors, Dopamine; Receptors, Serotonin; Spiperone; Stimulation, Chemical; Tyrosine

1980
The effects of serotonin antagonists in a behavioral despair procedure in mice.
    European journal of pharmacology, 1984, Dec-15, Volume: 107, Issue:1

    Topics: Animals; Behavior, Animal; Cyproheptadine; Guinea Pigs; Ketanserin; Male; Methysergide; Mice; Muscle, Smooth; Piperidines; Pizotyline; Rats; Rats, Inbred Strains; Receptors, Histamine; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Trazodone; Tritium

1984
Acute and chronic effects of serotonin (5HT) antagonists on serotonin binding sites.
    Naunyn-Schmiedeberg's archives of pharmacology, 1983, Volume: 324, Issue:2

    Topics: Animals; Binding Sites; Cyproheptadine; Male; Metergoline; Methysergide; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Spiperone

1983
A sensitive assay for studying dopaminergic activity in cultures of rat pituitary cells.
    The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Bromocriptine; Cell Count; Cells, Cultured; Cyproheptadine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Evaluation, Preclinical; Female; Haloperidol; Pituitary Gland; Prolactin; Rats; Rats, Wistar; Spiperone

1997