spiperone has been researched along with colforsin in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (16.67) | 18.7374 |
| 1990's | 25 (59.52) | 18.2507 |
| 2000's | 10 (23.81) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Albert, PR; Civelli, O; Liu, YF; Zhou, QY | 1 |
| Newman, ME | 1 |
| Deng, MH; Lopez G-Coviella, I; Lynch, HJ; Wurtman, RJ | 1 |
| Barton, AC; Monsma, FJ; Sibley, DR | 1 |
| Flawia, MM; Gershanik, O; Muschietti, JP; Rubinstein, M; Stefano, FJ | 1 |
| Nowak, JZ; Schorderet, M | 1 |
| De Vivo, M; Maayani, S | 1 |
| Beaulieu, M; Felder, R; Kebabian, JW | 1 |
| Battaglia, G; Creese, I; Hess, EJ; Norman, AB | 1 |
| Devivo, M; Maayani, S | 1 |
| Lin, C; McGonigle, P; Molinoff, PB | 1 |
| Gottesfeld, Z; Lingham, RB | 1 |
| Affolter, HU; Cote, TE; Felder, R; Kebabian, JW; Reisine, T; Sekura, RD | 1 |
| Asghari, V; Buchwaldt, S; Jovanovic, V; Paterson, A; Sanyal, S; Van Tol, HH | 1 |
| Borrelli, E; Guiramand, J; Montmayeur, JP | 1 |
| Frail, DE; Kebabian, JW; MacKenzie, RG; Roberts, E; Steffey, ME | 1 |
| Ball, S; Boyfield, I; Coldwell, MC; Cook, T; Gloger, IS; Herrity, N; McHale, M; Robinson, JH; Winn, FM | 1 |
| Adham, N; Bard, J; Branchek, TA; Durkin, M; Hartig, PR; Kao, HT; Olsen, M; Schecter, LE; Urquhart, D; Weinshank, RL | 1 |
| Leysen, JE; Pauwels, PJ; Van Gompel, P | 1 |
| Allard, S; Falardeau, P; Lapointe, S | 1 |
| Palmier, C; Pauwels, PJ | 1 |
| Felder, RA; Jose, PA; Walk, SF; Yamaguchi, I | 1 |
| Cravchik, A; Gejman, PV; Sibley, DR | 1 |
| Neve, KA; Watts, VJ | 1 |
| Grünewald, S; Michel, H; Reiländer, H | 1 |
| Arilla, E; Juarranz, MG; López-Sañudo, S; Martín-Espinosa, A; Puebla, L; Rodríguez-Martín, E; Rodríguez-Pena, MS; Rodríguez-Sánchez, MN | 1 |
| Bobirnac, I; Bruinvels, AT; Danzeisen, M; Gazi, L; Geisse, S; Hoyer, D; Schoeffter, P; Schüpbach, E; Sommer, B; Tricklebank, M | 1 |
| Chu, A; Schetz, JA; Sibley, DR | 1 |
| de Mello, FG; Linden, R; Varella, MH | 1 |
| Braun, K; Poeggel, G; Reiser, M; Schnabel, R; Schröder, H | 1 |
| Kumar, U; Lange, DC; Patel, RC; Patel, SC; Patel, YC; Rocheville, M | 1 |
| Croskery, K; Feuerbach, D; Gazi, L; Hoyer, D; Nunn, C; Schoeffter, P | 1 |
| George, SR; Liu, IS; Seeman, P | 1 |
| Armogida, M; Chiacchio, S; Colzi, A; Corsini, GU; DeMontis, MG; Maggio, R; Scarselli, M | 1 |
| Fu, D; Javitch, JA; Lin, H; Strange, PG; Wilson, J | 1 |
| Barrio, JR; Gambhir, SS; Herschman, HR; Liang, Q; Phelps, MP; Satyamurthy, N; Toyokuni, T | 1 |
| Burris, KD; Kikuchi, T; Molinoff, PB; Molski, TF; Ryan, E; Tottori, K; Xu, C; Yocca, FD | 1 |
| Morales, M; Oz, M; Rotondo, A; Sun, H; Zhang, L | 1 |
| Ebadi, M; Govitrapong, P; Santanavanich, C | 1 |
| Kendall, RT; Senogles, SE | 1 |
2 review(s) available for spiperone and colforsin
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
Retinal dopamine D1 and D2 receptors: characterization by binding or pharmacological studies and physiological functions.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Arylamine N-Acetyltransferase; Benzazepines; Colforsin; Cyclic AMP; Dopamine; Ergolines; Light; Quinpirole; Receptors, Dopamine; Retina; Second Messenger Systems; Species Specificity; Spiperone; Sulpiride; Vertebrates | 1990 |
40 other study(ies) available for spiperone and colforsin
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Benzazepines; Calcium; Calcium Channels; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Dopamine; Enzyme Activation; GTP-Binding Proteins; Humans; Inositol Phosphates; Ion Channel Gating; L Cells; Mice; Nifedipine; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Pituitary Gland; Protein Kinases; Rats; Receptors, Dopamine; Signal Transduction; Spiperone; Sulpiride; Virulence Factors, Bordetella | 1992 |
Serotonin inhibits adenylate cyclase in human platelet membranes.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Binding Sites; Blood Platelets; Colforsin; Dose-Response Relationship, Drug; Humans; Methysergide; Quinoxalines; Receptors, Serotonin; Serotonin; Spiperone; Yohimbine | 1992 |
Melatonin and its precursors in Y79 human retinoblastoma cells: effect of sodium butyrate.
Topics: 5-Hydroxytryptophan; Analysis of Variance; Butyrates; Butyric Acid; Cell Line; Colforsin; Dopamine; Eye Neoplasms; Humans; Kinetics; Levodopa; Melatonin; Retinoblastoma; Serotonin; Spiperone | 1991 |
Expression of functional D2 dopamine receptors following differentiation of Y-79 human retinoblastoma cells.
Topics: Adenylyl Cyclase Inhibitors; Binding, Competitive; Cell Membrane; Colforsin; Dopamine; Dopamine Agents; Dopamine Antagonists; Eye Neoplasms; Guanylyl Imidodiphosphate; Humans; Receptors, Dopamine; Receptors, Dopamine D2; Retinoblastoma; Spiperone; Tumor Cells, Cultured | 1990 |
Adaptive mechanisms of striatal D1 and D2 dopamine receptors in response to a prolonged reserpine treatment in mice.
Topics: Adenylyl Cyclases; Animals; Benzazepines; Colforsin; Corpus Striatum; Magnesium; Male; Manganese; Mice; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reserpine; Spiperone | 1990 |
Stimulation and inhibition of adenylyl cyclase by distinct 5-hydroxytryptamine receptors.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Membrane; Cerebral Cortex; Colforsin; Drug Interactions; Enzyme Activation; Fluphenazine; Guinea Pigs; Hippocampus; Mathematics; Mianserin; Pindolol; Piperazines; Rats; Receptors, Serotonin; Spiperone | 1990 |
D-2 dopaminergic agonists and adenosine 3',5'-monophosphate directly regulate the synthesis of alpha-melanocyte-stimulating hormone-like peptides by cultured rat melanotrophs.
Topics: 1-Methyl-3-isobutylxanthine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Benzamides; Benzazepines; Bromocriptine; Cells, Cultured; Chemical Precipitation; Cholera Toxin; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Dopamine; Ergolines; Immunologic Techniques; Melanocyte-Stimulating Hormones; Pituitary Gland; Pro-Opiomelanocortin; Quinpirole; Rats; Receptors, Dopamine; Spiperone | 1986 |
D2 dopamine receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in rat striatum.
Topics: Adenylyl Cyclases; Animals; Benzazepines; Bromocriptine; Butyrophenones; Colforsin; Corpus Striatum; Ergolines; In Vitro Techniques; Male; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1985 |
Inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT receptor agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Tetrahydronaphthalenes | 1985 |
Characterization of D-2 dopamine receptors in a tumor of the rat anterior pituitary gland.
Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Colforsin; Dopamine; Female; Guanosine Triphosphate; Pituitary Gland, Anterior; Pituitary Neoplasms; Rats; Rats, Inbred BUF; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1987 |
Deafferentation elicits increased dopamine-sensitive adenylate cyclase and receptor binding in the olfactory tubercle.
Topics: Adenylyl Cyclases; Afferent Pathways; Animals; Colforsin; Dopamine; Enzyme Activation; GTP-Binding Proteins; Male; Olfactory Bulb; Rats; Receptors, Dopamine; Sodium Fluoride; Spiperone | 1986 |
D-2 dopamine receptor-mediated inhibition of pro-opiomelanocortin synthesis in rat intermediate lobe. Abolition by pertussis toxin or activators of adenylate cyclase.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Bromocriptine; Butyrophenones; Cholera Toxin; Colforsin; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; In Vitro Techniques; Male; Molecular Weight; Pertussis Toxin; Pituitary Gland; Pro-Opiomelanocortin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Virulence Factors, Bordetella | 1986 |
Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants.
Topics: Animals; Benzamides; Cell Line; CHO Cells; Clozapine; Colforsin; Cricetinae; Cyclic AMP; Dinoprostone; Dopamine; Haloperidol; HeLa Cells; Humans; Raclopride; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone; Transfection | 1995 |
Preferential coupling between dopamine D2 receptors and G-proteins.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Colforsin; Dopamine; GTP-Binding Proteins; Humans; Receptors, Dopamine; RNA Splicing; RNA, Messenger; Signal Transduction; Spiperone; Transfection; Tumor Cells, Cultured | 1993 |
Further characterization of the D2 dopamine receptor expressed in MMQ cells.
Topics: Animals; Base Sequence; Colforsin; Cyclic AMP; DNA; Dopamine Agents; Molecular Sequence Data; Polymerase Chain Reaction; Radioligand Assay; Rats; Receptors, Dopamine D2; Spiperone; Tritium; Tumor Cells, Cultured | 1993 |
Expression and functional characterisation of a synthetic version of the human D4 dopamine receptor in a stable human cell line.
Topics: Adenylyl Cyclases; Animals; Base Sequence; Binding, Competitive; Cell Line; Chlorocebus aethiops; Colforsin; DNA; Ergolines; Genes, Synthetic; Humans; Kidney; Kinetics; Molecular Sequence Data; Plasmids; Quinpirole; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Restriction Mapping; Spiperone; Transfection | 1994 |
Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; Colforsin; Dose-Response Relationship, Drug; Gene Library; Guinea Pigs; Humans; Indoles; Lymphocytes; Molecular Sequence Data; Receptors, Serotonin; RNA, Messenger; Sequence Homology, Amino Acid; Serotonin; Serotonin Receptor Agonists; Spiperone; Sulfonamides; Sumatriptan; Tissue Distribution | 1993 |
Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1A receptors that are negatively coupled to adenylate cyclase in permanently transfected HeLa cells.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Colforsin; Cyclic AMP; HeLa Cells; Humans; Indoles; Lysergic Acid Diethylamide; Models, Biological; Pindolol; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Transfection | 1993 |
Specific induction of a functional endogenous D2 short dopamine receptor in GH4C1 cells.
Topics: Animals; Apomorphine; Base Sequence; Colforsin; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Ergolines; Gene Expression; Kanamycin Kinase; Kinetics; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotransferases; Pituitary Neoplasms; Polymerase Chain Reaction; Potassium Chloride; Prolactin; Quinpirole; Rats; Receptors, Dopamine D2; Recombinant Fusion Proteins; Spiperone; Sulpiride; Transfection; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1993 |
Functional effects of the 5-HT1D receptor antagonist GR 127,935 at human 5-HT1D alpha, 5-HT1D beta, 5-HT1A and opossum 5-HT1B receptors.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; HeLa Cells; Humans; Methiothepin; Opossums; Oxadiazoles; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Transfection | 1995 |
Dopamine D2L receptors stimulate Na+/K(+)-ATPase activity in murine LTK- cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Colforsin; Cyclic AMP; Dideoxyadenosine; Dopamine Agonists; Ergolines; Kinetics; L Cells; Mice; Ouabain; Pertussis Toxin; Quinpirole; Rats; Receptors, Dopamine D2; Recombinant Proteins; Rubidium; Sodium-Potassium-Exchanging ATPase; Spiperone; Transfection; Virulence Factors, Bordetella | 1996 |
Functional analysis of the human D2 dopamine receptor missense variants.
Topics: Animals; Binding, Competitive; Cell Line; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine; Dopamine Agonists; Female; Humans; Kinetics; Ovary; Polymorphism, Genetic; Receptors, Dopamine D2; Spiperone | 1996 |
Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors.
Topics: Adenylyl Cyclases; Cells, Cultured; Colforsin; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Isoenzymes; Isoproterenol; Kinetics; Receptors, Dopamine D2; Recombinant Proteins; Second Messenger Systems; Sensitivity and Specificity; Spiperone; Stimulation, Chemical; Tetrahydronaphthalenes | 1996 |
In vivo reconstitution of dopamine D2S receptor-mediated G protein activation in baculovirus-infected insect cells: preferred coupling to Gi1 versus Gi2.
Topics: Adenosine Triphosphate; Animals; Apomorphine; Baculoviridae; Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Dopamine Agonists; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Receptors, Dopamine D2; Spiperone; Spodoptera | 1996 |
Dopamine enhances somatostatin receptor-mediated inhibition of adenylate cyclase in rat striatum and hippocampus.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Benzazepines; Colforsin; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; GTP-Binding Proteins; Hippocampus; Immunologic Techniques; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin; Somatostatin; Spiperone | 1997 |
The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor.
Topics: Aminopyridines; Antipsychotic Agents; Cell Line; Clozapine; Colforsin; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Humans; Kidney; Piperidines; Pyridines; Pyrroles; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone | 1998 |
Zinc modulates antagonist interactions with D2-like dopamine receptors through distinct molecular mechanisms.
Topics: Algorithms; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Kinetics; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Salicylamides; Sodium; Spiperone; Thermodynamics; Zinc | 1999 |
Evidence for an antiapoptotic role of dopamine in developing retinal tissue.
Topics: Animals; Animals, Newborn; Anisomycin; Apoptosis; Benzazepines; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Agonists; Dopamine Antagonists; Protein Synthesis Inhibitors; Rats; Rats, Inbred Strains; Retina; Signal Transduction; Spiperone | 1999 |
Effect of social experience on dopamine-stimulated adenylyl cyclase activity and G protein composition in chick forebrain.
Topics: Adenylyl Cyclases; Animals; Animals, Newborn; Benzazepines; Chickens; Colforsin; Cyclic AMP; Dopamine; Dopamine Antagonists; Enzyme Activation; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Imprinting, Psychological; In Vitro Techniques; Prosencephalon; Receptors, Dopamine D1; Receptors, Dopamine D2; Social Isolation; Spiperone; Stimulation, Chemical | 1999 |
Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity.
Topics: Animals; Cell Membrane; Cerebral Cortex; CHO Cells; Colforsin; Corpus Striatum; Cricetinae; Cyclic AMP; Dimerization; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; Ligands; Male; Neurons; Pyramidal Cells; Quinpirole; Rats; Receptor Cross-Talk; Receptors, Dopamine D2; Receptors, Somatostatin; Somatostatin; Spiperone; Sulpiride; Transfection | 2000 |
Cloning, expression, functional coupling and pharmacological characterization of the rat dopamine D4 receptor.
Topics: Animals; Binding, Competitive; Calcium; Cells, Cultured; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; DNA-Binding Proteins; DNA, Complementary; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Nuclear Proteins; Pertussis Toxin; Rats; Receptors, Dopamine D2; Receptors, Dopamine D4; Serum Response Factor; Spiperone; Sulfur Radioisotopes; Transfection; Tritium; Virulence Factors, Bordetella | 2000 |
The human dopamine D2(Longer) receptor has a high-affinity state and inhibits adenylyl cyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alternative Splicing; Animals; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Dopamine; Dopamine Antagonists; Enzyme Activation; Guanylyl Imidodiphosphate; Humans; Receptors, Dopamine D2; Spiperone; Thermodynamics | 2000 |
Reconstitution of functional dopamine D(2s) receptor by co-expression of amino- and carboxyl-terminal receptor fragments.
Topics: Animals; Apomorphine; Binding, Competitive; Clozapine; Colforsin; COS Cells; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Membranes; Peptide Fragments; Pergolide; Quinpirole; Radioligand Assay; Rats; Receptors, Dopamine D2; Recombinant Fusion Proteins; Spiperone; Transfection; Tritium | 2000 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
Noninvasive, quantitative imaging in living animals of a mutant dopamine D2 receptor reporter gene in which ligand binding is uncoupled from signal transduction.
Topics: Adenoviridae; Animals; Cell Line; Colforsin; Cyclic AMP; Dopamine; Genes, Reporter; Genetic Vectors; Injections, Intravenous; Liver; Mice; Point Mutation; Protein Binding; Rats; Receptors, Dopamine D2; Signal Transduction; Spiperone; Tomography, Emission-Computed; Tumor Cells, Cultured | 2001 |
Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antipsychotic Agents; Aripiprazole; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; GTP-Binding Proteins; Humans; Piperazines; Quinolones; Radioligand Assay; Receptors, Dopamine D2; Signal Transduction; Spiperone | 2002 |
Direct activation by dopamine of recombinant human 5-HT1A receptors: comparison with human 5-HT2C and 5-HT3 receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Chelating Agents; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanosine Diphosphate; Haloperidol; Humans; Indazoles; Inhibitory Concentration 50; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Pertussis Toxin; Piperazine; Piperazines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT2; Receptors, Serotonin, 5-HT3; Recombinant Proteins; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Thionucleotides; Tropanes; Xenopus laevis | 2003 |
Dopamine receptor activation in bovine pinealocyte via a cAMP-dependent transcription pathway.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acyltransferases; Animals; Benzazepines; Cattle; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Melatonin; Phosphorylation; Pineal Gland; Quinpirole; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Spiperone; Transcription, Genetic | 2005 |
Investigation of the alternatively spliced insert region of the D2L dopamine receptor by epitope substitution.
Topics: Alternative Splicing; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; Binding, Competitive; Blotting, Northern; Blotting, Western; Cell Line; Cloning, Molecular; Colforsin; Cyclic AMP; Dopamine Agents; Dopamine Antagonists; Dose-Response Relationship, Drug; Epitopes; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Models, Molecular; Receptors, Dopamine D2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Spiperone; Time Factors; Transfection | 2006 |