spiperone has been researched along with clozapine in 97 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (24.74) | 18.7374 |
| 1990's | 47 (48.45) | 18.2507 |
| 2000's | 19 (19.59) | 29.6817 |
| 2010's | 7 (7.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| George, SR; Guan, HC; Laurier, LG; Ng, G; Niznik, HB; O'Dowd, BF; Seeman, P; Sunahara, RK; Torchia, J; Van Tol, HH | 1 |
| Bouthenet, ML; Giros, B; Martres, MP; Schwartz, JC; Sokoloff, P | 1 |
| Butler, DE; Coughenour, LL; DeWald, HA; Downs, DA; Lewis, EP; Lobbestael, SJ; Pattison, IC; Poschel, BP; Tecle, H; Wise, LD | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Demattos, S; MacKenzie, RG; O'Malley, KL; Pugsley, TA; Shih, YH; Tang, L; Todd, RD; VanLeeuwen, D | 1 |
| Choudhary, MS; Craigo, SC; Meltzer, HY; Monsma, FJ; Roth, BL; Shen, Y; Sibley, DR; Uluer, A | 1 |
| Heller, A; O'Malley, KL; Tang, L; Todd, RD | 1 |
| Amlaiky, N; Hen, R; Plassat, JL | 1 |
| Arrang, JM; Diaz, J; Leurs, R; Ruat, M; Schwartz, JC; Tardivel-Lacombe, J; Traiffort, E | 1 |
| Baez, M; Kursar, JD; Lucaites, VL; Nelson, DL; Sasso, DA; Wainscott, DB | 1 |
| Egan, CT; Herrick-Davis, K; Teitler, M | 1 |
| Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Conklin, DS; Fitzgerald, LW; Hartig, PR; Iyer, G; Kostich, WA; Krause, CM; Largent, BL; Marshall, AP; Patterson, JP; Tran, DP | 1 |
| Benhamú, B; Lavandera, JL; López-Rodríguez, ML; Morcillo, MJ; Porras, E; Ramos, JA | 1 |
| Grinde, E; Herrick-Davis, K; Teitler, M | 1 |
| Bach, T; Krobert, KA; Kvingedal, AM; Levy, FO; Syversveen, T | 1 |
| Itoh, H; Muramatsu, I; Taniguchi, T; Yoshio, R | 1 |
| Glennon, RA | 1 |
| Fang, X; Hu, Z; Levant, B; Min, J; Varady, J; Wang, S; Wu, X | 1 |
| Benhamú, B; Campillo, M; Lavandera, JL; López-Rodríguez, ML; Morcillo, MJ; Olivella, M; Pardo, L; Porras, E; Ramos, JA; Soto, LJ | 1 |
| Benwell, K; Bickerdike, M; Kennett, G; Knight, AR; Misra, A; Quirk, K; Revell, D | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, Y; Liu, BF; Liu, S; Liu, X; Qiu, Y; Wang, S; Xu, X; Yu, M; Zhang, G; Zhang, T; Zhao, S | 1 |
| Deng, X; Fu, W; Guo, L; Xu, L; Yu, K; Zhao, W; Zhen, X | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Benachour, N; Vanderheyden, PML | 1 |
| Cao, X; Chen, Y; Liu, BF; Liu, X; Qiu, Y; Xu, X; Yu, M; Zhang, G; Zhang, L; Zhang, Y | 1 |
| Coupet, J; Rauh, CE | 1 |
| Fang, VS; Goode, DJ; Meltzer, HY; Schyve, PM; Young, M | 1 |
| Carlson, KR; Eibergen, RD | 2 |
| Bunzow, JR; Civelli, O; Guan, HC; Jovanovic, V; Kennedy, J; Niznik, HB; Ohara, K; Seeman, P; Van Tol, HH; Wu, CM | 1 |
| Cohen, AI; Harmon, S; O'Malley, KL; Todd, RD | 1 |
| Meltzer, HY; Stockmeier, CA | 1 |
| Belknap, JK; de Paulis, T; Janowsky, A; Kinzie, JM; Neve, KA; Taylor, B | 1 |
| Braff, DL; Geyer, MA; Keith, VA; Swerdlow, NR | 1 |
| Coenen, HH; Hamacher, K; Heiss, WD; Herholz, K; Huber, M; Karbe, H; Lövenich, A; Stöcklin, G; Wienhard, K | 1 |
| Ashby, CR; Wang, RY | 1 |
| Murray, AM; Waddington, JL | 1 |
| Amdur, RL; Carvey, PM; Kao, LC; Klawans, HL; Lin, DH; Nath, ST; Singh, R; Zhang, TJ | 1 |
| Szczepanik, AM; Wilmot, CA | 1 |
| Berghoff, W; Coughenour, LL; Courtland, GG; Myers, SL; Pugsley, TA; Shih, YH; Stewart, SF | 1 |
| Andree, TH; Koenig, JI; Meltzer, HY; Mikuni, M; Tong, CY | 1 |
| Aghajanian, GK; Rasmussen, K | 1 |
| Jenner, P; Marsden, CD; Rupniak, NM | 1 |
| Axelsson, S; Eckernäs, SA; Ekblom, B; Fasth, KJ; Gullberg, P; Hartvig, P; Långström, B; Lindström, L; Lundqvist, H | 1 |
| Fleminger, S; Hall, MD; Jenner, P; Kilpatrick, G; Mann, S; Marsden, CD; Rupniak, NM | 1 |
| Gay, DD; Lahti, RA | 1 |
| Eichenberger, E | 1 |
| Fujiwara, T; Kikuchi, H; Mori, J; Ono, T; Satoh, H; Shimomura, K | 1 |
| Hall, MD; Jenner, P; Kilpatrick, G; Marsden, CD; Rupniak, NM | 1 |
| Gardner, EL; Seeger, TF; Thal, L | 1 |
| Baez, LA; Burt, DK; Crowner, ML; Hungerford, SM | 1 |
| Harris, TW; Manier, DH; Mobley, PL; Smith, HE; Sulser, F | 1 |
| Audiau, F; Carpy, A; Guérémy, C; Le Fur, G; Léger, JM; Uzan, A | 1 |
| Angeby, T; Haglund, L; Köhler, C; Ogren, SO | 1 |
| Betts, CR; de Paulis, T; Manier, DH; Mobley, PL; Smith, HE; Sulser, F | 1 |
| Baum, MJ; Starr, MS | 1 |
| Durcan, MJ; Morgan, PF; Norman, MH; Rigdon, GC | 1 |
| Farde, L; Halldin, C; Karlsson, P; Nordström, AL; Nyberg, S; Sedvall, G | 1 |
| Omeljaniuk, RJ | 1 |
| Asghari, V; Buchwaldt, S; Jovanovic, V; Paterson, A; Sanyal, S; Van Tol, HH | 1 |
| Assié, MB; Koek, W; Sleight, AJ | 1 |
| Bruhwyler, J; Damas, J; Delarge, J; Geczy, J; Liégeois, JF; Masereel, B; Rogister, F | 1 |
| Farde, L; Halldin, C; Nordström, AL | 1 |
| Celander, M; Svartengren, J | 1 |
| Bernard, A; Cavegn, C; Chabert, C; Mills, A | 1 |
| Bole-Vunduk, B; Budihna, MV; Krisch, I; Lavric, B; Ocvirk, A; Pepelnak, M; Sket, D | 1 |
| Nowak, JZ; Zawilska, JB | 1 |
| Furukawa, K; Hino, K; Karasawa, T; Kurumiya, S; Noda, Y; Ochi, Y; Oka, M; Une, T | 1 |
| Heston, LL; Lind, TJ; Sobell, JL; Sommer, SS | 1 |
| DiCarlo, JJ; Meltzer, HY; Stockmeier, CA; Thompson, P; Zhang, Y | 1 |
| Beckmann, H; Fritze, J; Riederer, P; Wodarz, N | 1 |
| Burgess, LH; Meltzer, HY; Roth, BL; Sibley, DR; Tandra, S | 1 |
| Fukuda, T; Futamura, T; Haga, K; Ohashi, Y; Takahashi, Y; Yano, K | 1 |
| Lynch, AM; See, RE; Sorg, BA | 1 |
| Liu, IS; Rodgers-Johnson, PE; Sanyal, S; Seeman, P; Serjeant, GR; Ulpian, C; Van Tol, HH | 1 |
| Fritze, J; Riederer, P; Wodarz, N | 1 |
| Berridge, MS; Compton-Toth, BA; Goyer, PF; Meltzer, HY; Miraldi, F; Morris, ED; Schulz, SC; Semple, WE; Wong, DF | 1 |
| Creese, I; Florijn, WJ; Tarazi, FI | 1 |
| Kołodziejczyk, K; Maj, J; Rogóz, Z; Skuza, G | 1 |
| Li, L; Schafer, JA | 1 |
| Bobirnac, I; Bruinvels, AT; Danzeisen, M; Gazi, L; Geisse, S; Hoyer, D; Schoeffter, P; Schüpbach, E; Sommer, B; Tricklebank, M | 1 |
| Nowak, G; Ossowska, K; Pietraszek, M; Wardas, J; Wolfarth, S | 1 |
| Bradley, RJ; Dwyer, DS; Liu, Y | 1 |
| Jaliffa, CO; Lacoste, FF; Llomovatte, DW; Rosenstein, RE; Sarmiento, MI | 1 |
| Alper, RH; Gilliland, SL; Levant, B | 1 |
| Armogida, M; Chiacchio, S; Colzi, A; Corsini, GU; DeMontis, MG; Maggio, R; Scarselli, M | 1 |
| Fu, D; Javitch, JA; Lin, H; Strange, PG; Wilson, J | 1 |
| Gainetdinov, RR; Grekhova, TV; Rayevsky, KS; Sotnikova, TD | 1 |
| Dikic, B; Kassiou, M; Katsifis, A; Mardon, K; Mattner, F | 1 |
| Einsiedel, J; Gmeiner, P; Hübner, H | 1 |
| Jaliffa, CO; Keller Sarmiento, MI; Minces, L; Rosenstein, RE; Sacca, GB; Sáenz, DA | 1 |
| Bravi, D; Cavallaro, R; Colombo, C; Fazio, F; Galli, L; Gobbo, C; Lucignani, G; Messa, C; Moresco, RM; Rizzo, G; Smeraldi, E; Velonà, I | 1 |
| Brioni, JD; Chang, R; Cowart, MD; Donnelly-Roberts, DL; Hsieh, GC; Marsh, K; Miller, L; Miller, TR; Moreland, RB; Nakane, M; Namovic, MT; Stewart, AO; Terranova, MA; Uchic, ME; Wetter, JM | 1 |
| Alonso-Gomez, AL; Iuvone, PM; Ivanova, TN | 1 |
| Dalton, JAR; Giraldo, J; Marín, AR; Stove, C; Wouters, E | 1 |
2 review(s) available for spiperone and clozapine
| Article | Year |
|---|---|
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
Influence of the cellular environment on ligand binding kinetics at membrane-bound targets.
Topics: Angiotensin II Type 1 Receptor Blockers; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Humans; Kinetics; Ligands; Protein Binding; Receptor, Angiotensin, Type 1; Receptors, Cell Surface; Signal Transduction | 2017 |
2 trial(s) available for spiperone and clozapine
| Article | Year |
|---|---|
High 5-HT2 receptor occupancy in clozapine treated patients demonstrated by PET.
Topics: Adult; Antipsychotic Agents; Clozapine; Dopamine Agonists; Female; Humans; Male; Middle Aged; Prefrontal Cortex; Psychotic Disorders; Raclopride; Receptors, Serotonin; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed | 1993 |
Cerebral D2 and 5-HT2 receptor occupancy in Schizophrenic patients treated with olanzapine or clozapine.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Brain; Clozapine; Double-Blind Method; Female; Fluorine Radioisotopes; Humans; Male; Middle Aged; Olanzapine; Positron-Emission Tomography; Prospective Studies; Receptors, Dopamine D2; Receptors, Serotonin, 5-HT2; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Spiperone | 2004 |
93 other study(ies) available for spiperone and clozapine
| Article | Year |
|---|---|
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Blotting, Northern; Brain; Cell Line; Cell Membrane; Cloning, Molecular; Dopamine; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Oligonucleotide Probes; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D5; RNA, Messenger; Sequence Homology, Nucleic Acid; Transfection | 1991 |
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
Topics: Amino Acid Sequence; Animals; Antipsychotic Agents; Base Sequence; Brain Chemistry; Cell Line; Cloning, Molecular; Cricetinae; DNA; DNA Restriction Enzymes; Dopamine; Guanylyl Imidodiphosphate; Molecular Sequence Data; Nucleic Acid Hybridization; Polymerase Chain Reaction; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Sequence Homology, Nucleic Acid; Tissue Distribution | 1990 |
Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Catalepsy; Cebus; Chemical Phenomena; Chemistry; Haloperidol; Hypothalamus; Male; Mice; Motor Activity; Rats; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Muscarinic; Saimiri; Spiro Compounds; Structure-Activity Relationship | 1985 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Characterization of the human dopamine D3 receptor expressed in transfected cell lines.
Topics: Animals; Arachidonic Acid; Binding, Competitive; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agents; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Inositol Phosphates; Mice; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes; Transfection | 1994 |
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
Topics: Animals; Antipsychotic Agents; Cell Line; Molecular Structure; Rats; Receptors, Serotonin | 1994 |
Pharmacological and functional characterization of D2, D3 and D4 dopamine receptors in fibroblast and dopaminergic cell lines.
Topics: Adenylyl Cyclase Inhibitors; Animals; Base Sequence; Cells, Cultured; DNA Primers; Dopamine; Fibroblasts; GTP-Binding Proteins; Inositol Phosphates; Mice; Molecular Sequence Data; Neurons; Receptors, Dopamine; Transfection; Tumor Cells, Cultured | 1994 |
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Cyclic AMP; DNA; Drosophila; Enzyme Activation; Humans; Intestinal Mucosa; Mice; Molecular Sequence Data; Myocardium; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; CHO Cells; Cricetinae; Cyclic AMP; DNA; Genomic Library; Kinetics; Lysergic Acid Diethylamide; Mianserin; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; Organ Specificity; Rats; Receptors, Serotonin; Restriction Mapping; Serotonin; Serotonin Receptor Agonists; Transfection | 1993 |
[3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor.
Topics: Adrenergic alpha-Antagonists; Benzofurans; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Imidazoles; Radioligand Assay; Receptor, Serotonin, 5-HT2B; Receptors, Serotonin; Serotonin Antagonists; Transfection; Tritium; Yohimbine | 1998 |
Creation of a constitutively activated state of the 5-hydroxytryptamine2A receptor by site-directed mutagenesis: inverse agonist activity of antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; COS Cells; Mutagenesis, Site-Directed; Phosphatidylinositols; Protein Conformation; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Structure-Activity Relationship | 1998 |
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes | 1998 |
High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.
Topics: Amphetamines; Binding, Competitive; Cell Line; Ergolines; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrolysis; Isomerism; Ligands; Models, Biological; Phosphatidylinositols; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone | 1999 |
First pharmacophoric hypothesis for 5-HT7 antagonism.
Topics: Animals; Cell Membrane; Drug Design; Drug Evaluation, Preclinical; Hypothalamus; Models, Molecular; Rats; Receptors, Serotonin; Reproducibility of Results; Serotonin Antagonists; Structure-Activity Relationship | 2000 |
Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.
Topics: Animals; Antipsychotic Agents; COS Cells; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Radioligand Assay; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Receptor Agonists | 2000 |
The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution.
Topics: Adenylyl Cyclases; Alternative Splicing; Binding, Competitive; Brain; Cell Line; Cloning, Organism; Genetic Variation; Humans; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tissue Distribution | 2001 |
Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes.
Topics: Animals; Aorta, Thoracic; Carotid Arteries; Dogs; Humans; Male; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Serotonin Antagonists; Serotonin Receptor Agonists | 2001 |
Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.
Topics: Algorithms; Binding Sites; Computational Biology; Crystallography, X-Ray; Databases, Protein; Humans; Kinetics; Ligands; Lipid Bilayers; Models, Molecular; Molecular Conformation; Mutation; Receptors, Dopamine D2; Receptors, Dopamine D3; Reproducibility of Results; Solvents; Structure-Activity Relationship; Tetrahydronaphthalenes; Water | 2003 |
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.
Topics: Animals; Binding, Competitive; Computer Simulation; Drug Design; Hypothalamus; In Vitro Techniques; Lactams; Ligands; Male; Models, Molecular; Molecular Conformation; Naphthalenes; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides; Thiazoles | 2003 |
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
Topics: Binding Sites; Binding, Competitive; Cell Line; Humans; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2004 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Biological Availability; Coumarins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; In Vitro Techniques; Isoxazoles; Lethal Dose 50; Mice; Motor Activity; Prolactin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship; Weight Gain | 2013 |
Discovery of novel potent and selective ligands for 5-HT2A receptor with quinazoline scaffold.
Topics: Dose-Response Relationship, Drug; Drug Discovery; Humans; Ligands; Molecular Structure; Quinazolines; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Structure-Activity Relationship | 2015 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.
Topics: Animals; Antipsychotic Agents; Body Weight; Chemistry Techniques, Synthetic; Drug Design; Ether-A-Go-Go Potassium Channels; Heterocyclic Compounds; Memory; Mice; Piperazine; Rats; Schizophrenia; Structure-Activity Relationship; Tissue Distribution | 2018 |
3H-Spiroperidol binding to dopamine receptors in rat striatal membranes: influence of loxapine and its hydroxylated metabolites.
Topics: Animals; Butyrophenones; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzoxazepines; Haloperidol; Hydroxylation; In Vitro Techniques; Loxapine; Membranes; Rats; Receptors, Dopamine; Spiperone | 1979 |
Effect of clozapine on human serum prolactin levels.
Topics: Animals; Binding, Competitive; Chlorpromazine; Clozapine; Dibenzazepines; Female; Humans; Male; Prolactin; Rats; Receptors, Dopamine; Schizophrenia; Spiperone; Time Factors | 1979 |
Dyskinesias in monkeys: interaction of methamphetamine with prior methadone treatment.
Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methamphetamine; Naloxone; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Stereotyped Behavior | 1976 |
Susceptibility to amphetamine-elicited dyskinesias following chronic methadone treatment in monkeys.
Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Drug Interactions; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Macaca mulatta; Male; Methadone; Methamphetamine; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Time Factors | 1976 |
Multiple dopamine D4 receptor variants in the human population.
Topics: Base Sequence; Binding, Competitive; Cell Line; Clozapine; DNA; DNA Restriction Enzymes; Gene Expression; Genetic Variation; Humans; Introns; Molecular Sequence Data; Pituitary Gland; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Repetitive Sequences, Nucleic Acid; Spiperone; Substantia Nigra; Transfection | 1992 |
Photoreceptors of mouse retinas possess D4 receptors coupled to adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Base Sequence; Benzamides; Clozapine; Cyclic AMP; Ergolines; Gene Expression; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Molecular Sequence Data; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Quinpirole; Receptors, Dopamine; Retina; RNA, Messenger; Spiperone | 1992 |
In vivo occupancy of dopamine receptors by antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Haloperidol; Humans; Rats; Receptors, Dopamine; Receptors, Serotonin; Spiperone | 1992 |
Extrastriatal dopamine D2 receptors: distribution, pharmacological characterization and region-specific regulation by clozapine.
Topics: Amphetamine; Animals; Autoradiography; Benzamides; Brain; Clozapine; Haloperidol; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1992 |
Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat.
Topics: Analysis of Variance; Animals; Apomorphine; Benzazepines; Clozapine; Male; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reflex, Startle; Salicylamides; Schizophrenia; Spiperone | 1991 |
Positron emission tomography with (18F)methylspiperone demonstrates D2 dopamine receptor binding differences of clozapine and haloperidol.
Topics: Adult; Aged; Brain Chemistry; Clozapine; Female; Fluorine Radioisotopes; Glucose; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed; Tomography, X-Ray Computed | 1991 |
Effects of antipsychotic drugs on 5-HT2 receptors in the medial prefrontal cortex: microiontophoretic studies.
Topics: Amphetamines; Animals; Antipsychotic Agents; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Evoked Potentials; Frontal Lobe; Haloperidol; Iontophoresis; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone | 1990 |
The interaction of clozapine with dopamine D1 versus dopamine D2 receptor-mediated function: behavioural indices.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Benzazepines; Clozapine; Dopamine; Grooming; Male; Quinolines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone | 1990 |
Clozapine fails to prevent the development of haloperidol-induced behavioral hypersensitivity in a cotreatment paradigm.
Topics: Animals; Apomorphine; Behavior, Animal; Binding, Competitive; Brain Chemistry; Clozapine; Corpus Striatum; Dopamine; Drug Interactions; Haloperidol; Male; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Thioridazine | 1990 |
Effects of acute and chronic treatments with clozapine and haloperidol on serotonin (5-HT2) and dopamine (D2) receptors in the rat brain.
Topics: Animals; Autoradiography; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Image Processing, Computer-Assisted; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Septal Nuclei; Spiperone; Time Factors | 1989 |
CI-943, a potential antipsychotic agent. II. Neurochemical effects.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain Chemistry; Clozapine; Dopamine; Haloperidol; Imidazoles; In Vitro Techniques; Male; Mice; Neurotransmitter Agents; Norepinephrine; Prolactin; Pyrimidines; Rats; Rats, Inbred Strains; Serotonin; Spiperone | 1989 |
Differential effect of subchronic treatment with various neuroleptic agents on serotonin2 receptors in rat cerebral cortex.
Topics: 5,7-Dihydroxytryptamine; Animals; Antipsychotic Agents; Cerebral Cortex; Chlorpromazine; Clozapine; Female; Haloperidol; Imipramine; Ketanserin; Loxapine; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone; Sulpiride | 1986 |
Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity.
Topics: Amphetamines; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; DOM 2,5-Dimethoxy-4-Methylamphetamine; Electric Stimulation; Evoked Potentials; Haloperidol; Locus Coeruleus; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Serotonin; Sciatic Nerve; Spiperone; Sulpiride | 1988 |
Differential alteration of striatal D-1 and D-2 receptors induced by the long-term administration of haloperidol, sulpiride or clozapine to rats.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Dose-Response Relationship, Drug; Haloperidol; Humans; Kinetics; Long-Term Care; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior; Sulpiride; Thioxanthenes | 1985 |
Receptor binding and selectivity of three 11C-labelled dopamine receptor antagonists in the brain of rhesus monkeys studied with positron emission tomography.
Topics: Animals; Brain; Clozapine; Female; Macaca mulatta; Raclopride; Receptors, Dopamine; Salicylamides; Spiperone; Tissue Distribution; Tomography, Emission-Computed | 1988 |
Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat.
Topics: Acetylcholine; Animals; Apomorphine; Body Weight; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Male; Mastication; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Thioxanthenes; Tritium | 1985 |
Lack of effect of des-tyrosine1-gamma-endorphin on in vivo [3H]spiperone binding.
Topics: Animals; Antipsychotic Agents; Brain; Butyrophenones; Clozapine; Endorphins; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Spiperone | 1982 |
Pharmacology of fluperlapine compared with clozapine.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Apomorphine; Binding, Competitive; Brain Chemistry; Clozapine; Dibenzazepines; Dopamine; Electroencephalography; Homovanillic Acid; Humans; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1984 |
Effect of zotepine on fenfluramine-induced hyperthermia in rats.
Topics: Animals; Antipsychotic Agents; Body Temperature; Clozapine; Dibenzothiepins; Fenfluramine; Male; Piperazines; Rats; Rats, Inbred Strains; Spiperone | 1984 |
Differential alterations in striatal dopamine receptor sensitivity induced by repeated administration of clinically equivalent doses of haloperidol, sulpiride or clozapine in rats.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1984 |
Behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: studies with chronic clozapine and haloperidol.
Topics: Acetylcholine; Animals; Apomorphine; Behavior, Animal; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Postnatal development of a cholinergic influence on neuroleptic-induced catalepsy.
Topics: Aging; Animals; Atropine; Brain; Butyrophenones; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Female; Male; Motor Activity; Muridae; Reaction Time; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Muscarinic; Spiperone | 1982 |
Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Butyrophenones; Caudate Nucleus; Clozapine; Dibenzazepines; Dibenzoxepins; In Vitro Techniques; Rats; Spiperone | 1982 |
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.
Topics: Animals; Binding, Competitive; Butyrophenones; Chemical Phenomena; Chemistry; Clozapine; Corpus Striatum; Crystallography; Haloperidol; In Vitro Techniques; Molecular Conformation; Piperazines; Pyrimidines; Rats; Receptors, Dopamine; Spiperone; X-Ray Diffraction | 1982 |
Regional blockade by neuroleptic drugs of in vivo 3H-spiperone binding in the rat brain. Relation to blockade of apomorphine induced hyperactivity and stereotypies.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butyrophenones; Chlorpromazine; Clozapine; Haloperidol; Humans; Hyperkinesis; Kinetics; Organ Specificity; Rats; Receptors, Dopamine; Receptors, Drug; Spiperone; Stereotyped Behavior; Sulpiride; Thioridazine | 1981 |
Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain.
Topics: Animals; Binding Sites; Brain; Chemical Phenomena; Chemistry; Clozapine; Dibenzazepines; In Vitro Techniques; Kinetics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Spiperone | 1981 |
Inhibition of sexual behavior by dopamine antagonist or serotonin agonist drugs in castrated male rats given estradiol or dihydrotestosterone.
Topics: Animals; Castration; Clozapine; Dihydrotestosterone; Dopamine Antagonists; Estradiol; Male; Methoxydimethyltryptamines; Motor Activity; Rats; Serotonin; Sexual Behavior, Animal; Spiperone | 1980 |
Is clozapine selective for the dopamine D4 receptor?
Topics: Binding Sites; Cell Membrane; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Humans; Raclopride; Receptors, Dopamine D2; Salicylamides; Spiperone | 1995 |
D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients.
Topics: Adult; Benzazepines; Brain; Clozapine; Female; Humans; Male; Middle Aged; Raclopride; Receptors, Dopamine; Receptors, Serotonin; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed; Treatment Outcome | 1995 |
Specific [3H]spiperone binding sites in the pituitary of rainbow trout (Oncorhynchus mykiss) and goldfish (Carassius auratus).
Topics: Animals; Binding, Competitive; Clozapine; Domperidone; Dopamine; Dose-Response Relationship, Drug; Goldfish; Oncorhynchus mykiss; Pituitary Gland; Spiperone | 1995 |
Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants.
Topics: Animals; Benzamides; Cell Line; CHO Cells; Clozapine; Colforsin; Cricetinae; Cyclic AMP; Dinoprostone; Dopamine; Haloperidol; HeLa Cells; Humans; Raclopride; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone; Transfection | 1995 |
Biphasic displacement of [3H]YM-09151-2 binding in the rat brain by thioridazine, risperidone and clozapine, but not by other antipsychotics.
Topics: Animals; Antipsychotic Agents; Benzamides; Brain; Clozapine; Corpus Striatum; Dopamine D2 Receptor Antagonists; In Vitro Techniques; Isoxazoles; Male; Olfactory Pathways; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Risperidone; Spiperone; Thioridazine | 1993 |
Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor.
Topics: Apomorphine; Binding, Competitive; Cells, Cultured; Clozapine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Spiperone; Structure-Activity Relationship | 1995 |
The limbic functional selectivity of amperozide is not mediated by dopamine D2 receptors as assessed by in vitro and in vivo binding.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Clozapine; Dopamine; In Vitro Techniques; Limbic System; Male; Neostriatum; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Spiperone; Sulpiride | 1994 |
Characterization of the functional activity of dopamine ligands at human recombinant dopamine D4 receptors.
Topics: Animals; Cell Line; Clozapine; DNA; Dopamine; Dopamine Agents; Ergolines; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Ligands; Moths; Quinpirole; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone; Sulfur Radioisotopes; Tritium | 1994 |
Pharmacological studies with two new ergoline derivatives, the potential antipsychotics LEK-8829 and LEK-8841.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Antipsychotic Agents; Benzazepines; Blood Pressure; Catalepsy; Clozapine; Dose-Response Relationship, Drug; Ergolines; Haloperidol; Lysergic Acid; Male; Mice; Muscarinic Antagonists; Rats; Serotonin Antagonists; Spiperone | 1994 |
Dopamine receptor regulating serotonin N-acetyltransferase activity in chick retina represents a D4-like subtype: pharmacological characterization.
Topics: Animals; Arylamine N-Acetyltransferase; Benzamides; Benzazepines; Chickens; Circadian Rhythm; Clozapine; Dopamine; Dopamine Antagonists; Ergolines; Ketanserin; Male; Quinpirole; Receptors, Dopamine; Retina; Spiperone; Sulpiride | 1994 |
Pharmacological profile of AD-5423, a novel antipsychotic with both potent dopamine-D2 and serotonin-S2 antagonist properties.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Biogenic Monoamines; Clozapine; Dogs; Dopamine D2 Receptor Antagonists; Guinea Pigs; Haloperidol; Macaca fascicularis; Male; Mice; Mice, Inbred Strains; Neurotransmitter Uptake Inhibitors; Piperazines; Piperidines; Prosencephalon; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Tritium | 1993 |
Dopamine D4 receptor variants in unrelated schizophrenic cases and controls.
Topics: Adult; Aged; Alleles; Binding, Competitive; Case-Control Studies; Chi-Square Distribution; Clozapine; Electrophoresis, Agar Gel; Female; Gene Frequency; Genetic Variation; Genotype; Homozygote; Humans; Male; Middle Aged; Nucleic Acid Conformation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Protein Binding; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Repetitive Sequences, Nucleic Acid; Schizophrenia; Sequence Analysis, DNA; Spiperone | 1993 |
Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors.
Topics: Animals; Antipsychotic Agents; Binding Sites; Clozapine; Corpus Striatum; Dopamine Agents; Dose-Response Relationship, Drug; Kinetics; Male; Mice; Olfactory Pathways; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Serotonin; Spiperone; Tritium | 1993 |
3H-spiroperidol binding to peripheral mononuclear cells in schizophrenic and healthy subjects.
Topics: Adult; Binding, Competitive; Clozapine; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Radioligand Assay; Receptors, Dopamine; Schizophrenia; Schizophrenic Psychology; Spiperone | 1993 |
D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Clozapine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Risperidone; Spiperone | 1995 |
[The affinities of mosapramine for the dopamine receptor subtypes in human cell lines expressing D2, D3 and D4 receptors].
Topics: Antipsychotic Agents; Benzazepines; Cell Line; Clozapine; Haloperidol; Humans; Raclopride; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, Dopamine D5; Risperidone; Salicylamides; Spiperone | 1996 |
Subchronic administration of clozapine, but not haloperidol or metoclopramide, decreases dopamine D2 receptor messenger RNA levels in the nucleus accumbens and caudate-putamen in rats.
Topics: Actins; Animals; Antipsychotic Agents; Blotting, Northern; Brain Chemistry; Caudate Nucleus; Clozapine; Dopamine Antagonists; Haloperidol; Male; Metoclopramide; Nucleus Accumbens; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA, Messenger; Spiperone | 1996 |
Dopamine D4 receptor variant in Africans, D4valine194glycine, is insensitive to dopamine and clozapine: report of a homozygous individual.
Topics: Adolescent; Base Sequence; Binding, Competitive; Black or African American; Clozapine; Cyclic AMP; Dopamine; Genetic Variation; Humans; Male; Molecular Sequence Data; Receptors, Dopamine D2; Receptors, Dopamine D4; Spiperone; West Indies | 1996 |
3H-spiperone binding to peripheral mononuclear cells in psychiatric in-patients.
Topics: Adult; Binding, Competitive; Clozapine; Female; Haloperidol; Hospitalization; Humans; Lymphocytes; Male; Middle Aged; Schizophrenia; Spiperone | 1996 |
PET measurement of neuroreceptor occupancy by typical and atypical neuroleptics.
Topics: Adult; Antipsychotic Agents; Basal Ganglia; Bipolar Disorder; Carbon Radioisotopes; Case-Control Studies; Cerebral Cortex; Clozapine; Dopamine Agonists; Female; Humans; Male; Receptors, Dopamine D2; Receptors, Serotonin; Schizophrenia; Spiperone; Tomography, Emission-Computed | 1996 |
Dopamine receptor subtypes: differential regulation after 8 months treatment with antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Benzamides; Benzazepines; Brain; Clozapine; Corpus Striatum; Haloperidol; Iodine Radioisotopes; Male; Organ Specificity; Raclopride; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin; Salicylamides; Spiperone; Tetrahydronaphthalenes; Time Factors; Tritium; Up-Regulation | 1997 |
The behavioural effects of pramipexole, a novel dopamine receptor agonist.
Topics: Animals; Antiparkinson Agents; Benzazepines; Benzothiazoles; Body Temperature; Catalepsy; Clozapine; Dopamine Agents; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Haloperidol; Injections, Subcutaneous; Levodopa; Male; Mice; Motor Activity; Pramipexole; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Spiperone; Stereotyped Behavior; Sulpiride; Thiazoles | 1997 |
Dopamine inhibits vasopressin-dependent cAMP production in the rat cortical collecting duct.
Topics: Alkaloids; Animals; Arginine Vasopressin; Benzophenanthridines; Clozapine; Cyclic AMP; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Enzyme Inhibitors; Epinephrine; Fenoldopam; GTP-Binding Proteins; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Male; Naphthalenes; Phenanthridines; Pimozide; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D3; Receptors, Dopamine D4; Spiperone; Time Factors; Yohimbine | 1998 |
The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor.
Topics: Aminopyridines; Antipsychotic Agents; Cell Line; Clozapine; Colforsin; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Humans; Kidney; Piperidines; Pyridines; Pyrroles; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone | 1998 |
Chronic haloperidol and clozapine administration increases the number of cortical NMDA receptors in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antipsychotic Agents; Autoradiography; Cerebral Cortex; Clozapine; Corpus Striatum; Dizocilpine Maleate; Haloperidol; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Spiperone; Tritium | 1999 |
Dopamine receptor antagonists modulate glucose uptake in rat pheochromocytoma (PC12) cells.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Benzazepines; Biological Transport; Chlorpromazine; Clozapine; Dizocilpine Maleate; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Fluphenazine; Glucose; Haloperidol; PC12 Cells; Pimozide; Rats; Receptors, Dopamine D2; Spiperone; Sulpiride; Tritium | 1999 |
Dopamine decreases melatonin content in golden hamster retina.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzazepines; Chromatography, High Pressure Liquid; Circadian Rhythm; Clozapine; Cricetinae; Cyclic AMP; Depression, Chemical; Dopamine; Dopamine Agonists; Dopamine Antagonists; Kinetics; Male; Melatonin; Mesocricetus; Quinpirole; Receptors, Dopamine; Retina; Spiperone | 2000 |
Pharmacology of quinpirole-stimulated [35S]GTPgammaS binding: discrepancy with receptor binding profile.
Topics: Animals; Benzazepines; Binding, Competitive; Clorgyline; Clozapine; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Membranes; Monoamine Oxidase Inhibitors; Quinpirole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Selegiline; Spiperone; Sulfur Radioisotopes; Thiazoles | 2000 |
Reconstitution of functional dopamine D(2s) receptor by co-expression of amino- and carboxyl-terminal receptor fragments.
Topics: Animals; Apomorphine; Binding, Competitive; Clozapine; Colforsin; COS Cells; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Membranes; Peptide Fragments; Pergolide; Quinpirole; Radioligand Assay; Rats; Receptors, Dopamine D2; Recombinant Fusion Proteins; Spiperone; Transfection; Tritium | 2000 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study).
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Male; Microdialysis; Rats; Rats, Wistar; Receptors, Dopamine D3; Spiperone; Tetrahydronaphthalenes | 2001 |
Pharmacological evaluation of (+)-2- [123I]A-69024: a radioligand for in vivo studies of dopamine D1 receptors.
Topics: Animals; Benzazepines; Brain; Cerebellum; Clozapine; Corpus Striatum; Dopamine Antagonists; Haloperidol; Injections, Intravenous; Iodine Radioisotopes; Ketanserin; Ligands; Male; Papaverine; Rats; Rats, Wistar; Receptors, Dopamine D1; Spiperone; Stereoisomerism; Tetrahydroisoquinolines; Tetrahydronaphthalenes; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2001 |
Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179).
Topics: Animals; Biochemistry; Cattle; CHO Cells; Clozapine; Cricetinae; Cysteine; Dopamine Antagonists; Drug Design; Humans; In Vitro Techniques; Indoles; Magnetic Resonance Spectroscopy; Molecular Structure; Quinpirole; Receptors, Dopamine D2; Receptors, Dopamine D4; Serine; Spiperone; Stereoisomerism; Structure-Activity Relationship; Threonine | 2001 |
Photic regulation of heme oxygenase activity in the golden hamster retina: involvement of dopamine.
Topics: Animals; Benzazepines; Bilirubin; Bucladesine; Circadian Rhythm; Clozapine; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Enzyme Activation; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); In Vitro Techniques; Male; Mesocricetus; Photoperiod; Quinpirole; Retina; Spiperone; Thiobarbituric Acid Reactive Substances | 2003 |
2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.
Topics: Animals; Benzamides; Benzimidazoles; Binding, Competitive; Calcium; Cell Line; Clozapine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Europium; Fluorometry; GABA Antagonists; Guanosine Triphosphate; Humans; Male; Penile Erection; Piperazines; Pyridines; Pyrroles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spiperone; Time Factors; Tritium | 2005 |
Dopamine D4 receptors regulate intracellular calcium concentration in cultured chicken cone photoreceptor cells: relationship to dopamine receptor-mediated inhibition of cAMP formation.
Topics: Analysis of Variance; Animals; Arylalkylamine N-Acetyltransferase; Calcimycin; Calcium; Cells, Cultured; Chick Embryo; Clozapine; Cyclic AMP; Cyclic GMP; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Fura-2; GABA Antagonists; Intracellular Fluid; Ionophores; Potassium; Receptors, Dopamine D4; Retina; Retinal Cone Photoreceptor Cells; Spiperone | 2008 |
Distinct Dopamine D₂ Receptor Antagonists Differentially Impact D₂ Receptor Oligomerization.
Topics: Clozapine; Dimerization; Dopamine D2 Receptor Antagonists; Humans; Protein Binding; Receptors, Dopamine D2; Receptors, G-Protein-Coupled; Spiperone | 2019 |