spiperone has been researched along with 8-hydroxy-2-(di-n-propylamino)tetralin in 102 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (24.51) | 18.7374 |
| 1990's | 64 (62.75) | 18.2507 |
| 2000's | 12 (11.76) | 29.6817 |
| 2010's | 1 (0.98) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Newman-Tancredi, A; Strange, PG; Wootton, R | 1 |
| Bhatnagar, RK; Cannon, JG; Jackson, H; Leonard, P; Long, JP | 1 |
| Fozard, JR; Gittos, MW; Hibert, MF; Middlemiss, DN; Mir, AK | 1 |
| Glennon, RA | 2 |
| Adham, N; Bard, JA; Branchek, TA; Vaysse, P; Weinshank, RL; Zgombick, J | 1 |
| Kung, HF; Kung, MP; Zhuang, ZP | 1 |
| Amlaiky, N; Hen, R; Plassat, JL | 1 |
| Arrang, JM; Diaz, J; Leurs, R; Ruat, M; Schwartz, JC; Tardivel-Lacombe, J; Traiffort, E | 1 |
| Audia, JE; Baez, M; Cohen, ML; Kursar, JD; Lucaites, VL; Nelson, DL; Nissen, JS; Schenck, KW; Wainscott, DB | 1 |
| Dokhan, R; el Ahmad, Y; Laurent, E; Maillet, P; Ollivier, R; Talab, A; Teste, JF; Tran, G | 1 |
| Chang, DJ; Eglen, RM; Jasper, JR; Kosaka, A; To, ZP | 1 |
| Chaput, C; Millan, MJ; Newman-Tancredi, A; Verrièle, L | 1 |
| Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Bach, T; Krobert, KA; Kvingedal, AM; Levy, FO; Syversveen, T | 1 |
| Benwell, K; Bickerdike, M; Kennett, G; Knight, AR; Misra, A; Quirk, K; Revell, D | 1 |
| Berardi, F; Colabufo, NA; Contino, M; Lacivita, E; Leopoldo, M; Perrone, R | 1 |
| Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L | 1 |
| Lepailleur, A; Rochais, C; Thirumaran, SL | 1 |
| Newman-Tancredi, A; Strange, PG; Sundaram, H | 2 |
| Motevalian, M; Parsons, AA; Whalley, ET | 1 |
| Feniuk, W; Humphrey, PP; Perren, MJ | 1 |
| De Boer, T; Florijn, WJ; Tonnaer, JA; Van Nispen, JW; Versteeg, DH | 1 |
| Harris, LT; King, KA; McCall, RB | 1 |
| Gillis, RA; Kellar, KJ; Mandal, AK; Zhong, PY | 1 |
| Shippenberg, TS | 1 |
| Connor, HE; Feniuk, W; Stubbs, CM | 1 |
| Bolaños, FJ; Gozlan, H; Hamon, M; Laporte, AM; Schechter, LE | 1 |
| Darrow, EJ; Strahlendorf, HK; Strahlendorf, JC | 1 |
| Singer, EA; Valenta, B | 1 |
| Carlsson, A; Fredriksson, K; Grol, CJ; Hacksell, U; Johansson, AM; Sundell, S; Svensson, K | 1 |
| Davies, M; Fletcher, PJ | 1 |
| Geisler, A; Mørk, A | 1 |
| Bobker, DH; Williams, JT | 1 |
| Davidoff, RA; Hackman, JC; Holohean, AM | 2 |
| Budziszewska, B; Błaszczyńska, E; Chojnacka-Wójcik, E; Ismaiel, AM; Przegaliński, E; Tatarczyńska, E | 1 |
| Darmani, NA; Glennon, RA; Martin, BR; Pandey, U | 1 |
| Clement, ME; McCall, RB | 1 |
| Blier, P; Chaput, Y; de Montigny, C; Steinberg, S | 1 |
| Jenner, P; Marsden, CD; Stewart, BR | 1 |
| Caron, MG; Fargin, A; Lefkowitz, RJ; Lohse, MJ; Raymond, JR; Regan, JW; Senogles, SE | 1 |
| Friedman, E; Gillis, RA; Hamosh, P; Kellar, KJ; Mandal, AK; Pineo, SV | 1 |
| Murakami, H; Sano, M; Tsukimura, T; Yamazaki, A | 1 |
| Beck, SG; Clarke, WP; Goldfarb, J | 1 |
| Asarch, KB; Ransom, RW; Shih, JC | 1 |
| Duckles, SP; Nelson, DL; Taylor, EW | 1 |
| Devivo, M; Maayani, S | 1 |
| Appel, JB; Cunningham, KA | 1 |
| Allen, GS; Huang, S; Peroutka, SJ | 1 |
| Gudelsky, GA; Koenig, JI; Meltzer, HY | 2 |
| Green, JP; Maayani, S; Shenker, A; Weinstein, H | 1 |
| Besselievre, R; Cossery, JM; el Mestikawy, S; Emerit, MB; Gozlan, H; Hamon, M; Marquet, A | 1 |
| Lambert, G; Monroe, PJ; Nelson, DL; Yamamura, HI | 1 |
| Amedro, J; Brown, L; Smith, D; Williams, G | 1 |
| Lum, JT; Piercey, MF | 1 |
| Dills, C; DuMontier, G; Jeng, I; Soblosky, JS | 1 |
| Anderson, EG; Marszalec, W; Scroggs, RS | 1 |
| De Jonge, A; Doods, HN; Kalkman, HO; Thoolen, MJ; Timmermans, PB; Van Zwieten, PA; Wilffert, B | 1 |
| Artaud, F; Bourgoin, S; Goetz, C; Gozlan, H; Hall, MD; Hamon, M; Horn, AS | 1 |
| May, T; Oehler, J; Rilke, O; Wolffgramm, J | 1 |
| Amano, M; Ishizuka, T; Kubo, T; Ozaki, S; Taguchi, K | 1 |
| Fornal, CA; Jacobs, BL; Litto, WJ; Marrosu, F; Metzler, CW; Tada, K | 1 |
| Couvée, JH; Dijcks, FA; Ruigt, GS | 1 |
| Fujiwara, Y; Hamagishi, Y; Hikiji, M; Kashihara, K; Ohnuki, T; Oki, T; Otsuki, S; Roeske, WR; Sora, I; Tomita, H | 1 |
| Fox, AP; Kelly, JS; Penington, NJ | 1 |
| Damaj, MI; Glennon, RA; Martin, BR | 1 |
| Berardi, F; Colabufo, NA; Fiorentini, F; Govoni, S; Olgiati, V; Perrone, R; Tortorella, V; Vanotti, E | 1 |
| Blier, P; de Montigny, C; Dennis, T | 1 |
| Escandon, NA; McCall, RB; Zimmermann, DC | 1 |
| Andersson, J; Hartvig, P; Inoue, O; Kanai, T; Långström, B; Lilja, A; Tani, Y; Watanabe, Y | 1 |
| Andersson, J; Hartvig, P; Ishihara, T; Kanai, T; Lilija, A; Ohno, T; Onoe, H; Tani, Y; Watanabe, Y; Westerberg, G | 1 |
| Jeffrey, JJ; Rydelek-Fitzgerald, L; Teitler, M; Wilcox, BD | 1 |
| Behbehani, MM; Jiang, M; Liu, H; Pun, RY; Shipley, MT | 1 |
| Leysen, JE; Pauwels, PJ; Van Gompel, P | 1 |
| Aune, TM; Bombara, MP; Kelley, KA; McGrath, KM; Sarr, T | 1 |
| Blier, P; De Montigny, C; Lista, A | 1 |
| Aleksandrova, IA; Bobkova, NV; Gurevich, EV; Katkov, YA; Nesterova, IV; Otmakhova, NA | 1 |
| Gidener, S; LePard, KJ; Stephens, RL | 1 |
| Hery, F; Pesce, G | 1 |
| IJzerman, AP; Kruse, CG; Kuipers, W; Spek, AL; Standaar, PJ; Tulp, MT; van Wijngaarden, I; Veldman, N | 1 |
| Dukić, S; Joksimović, J; Soskić, V; Vujović, M | 1 |
| Ichikawa, J; Meltzer, HY; Sumiyoshi, T | 1 |
| Gajendiran, M; Ganguly, DK; Seth, P | 1 |
| Draguhn, A; Empson, RM; Gloveli, T; Heinemann, U; Schmitz, D | 1 |
| Chairungsrilerd, N; Furukawa, K; Kisara, K; Ohizumi, Y; Tadano, T | 1 |
| Dun, NJ; Hwang, LL | 1 |
| Blier, P; de Montigny, C; Mongeau, R; Weiss, M | 1 |
| Christ, G; Kaynan, A; Maayani, S; Melman, A; Rehman, J; Valcic, M | 1 |
| Arnold, PB; Cardenas, CG; Cardenas, LM; Mar, LP; Scroggs, RS; Surmeier, DJ; Vysokanov, AV | 1 |
| Chu, TC; Ogidigben, MJ; Potter, DE | 1 |
| Bult, H; Geerts, IS; Herman, AG; Matthys, KE | 1 |
| Csépe, V; Hegerl, U; Juckel, G; Karmos, G; Molnár, M | 1 |
| Akunne, HC; Cooke, LW; Davis, MD; Georgic, LM; Heffner, TG; MacKenzie, RG; Meltzer, LT; Pugsley, TA; Shih, YH; Whetzel, SZ; Wise, LD; Wustrow, DJ; Zoski, KT | 1 |
| Collin, L; Ho, M; Price, GW; Riley, G; Scott, C; Selkirk, JV; Watson, J | 1 |
| Davidson, C; Hopwood, SE; McLaughlin, DP; Stamford, JA | 1 |
| Fu, D; Javitch, JA; Lin, H; Strange, PG; Wilson, J | 1 |
| Gainetdinov, RR; Grekhova, TV; Rayevsky, KS; Sotnikova, TD | 1 |
| de Moes, J; Feenstra, RW; Hofma, JJ; Kling, H; Kruse, CG; Kuipers, W; Long, SK; Tulp, MT; van der Heyden, JA | 1 |
| Morales, M; Oz, M; Rotondo, A; Sun, H; Zhang, L | 1 |
4 review(s) available for spiperone and 8-hydroxy-2-(di-n-propylamino)tetralin
| Article | Year |
|---|---|
Central serotonin receptors as targets for drug research.
Topics: Animals; Humans; Receptors, Serotonin; Research Design; Serotonin | 1987 |
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
Structure-activity relationships of serotonin 5-HT
Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship | 2019 |
Control of dorsal raphé 5-HT function by multiple 5-HT(1) autoreceptors: parallel purposes or pointless plurality?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Autoreceptors; Dimerization; Guinea Pigs; Humans; Ion Channels; Ion Transport; Mice; Nerve Tissue Proteins; Neurons; Oxadiazoles; Piperazines; Protein Isoforms; Pyridines; Pyrimidines; Raphe Nuclei; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Second Messenger Systems; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists; Spiperone; Sumatriptan | 2000 |
98 other study(ies) available for spiperone and 8-hydroxy-2-(di-n-propylamino)tetralin
| Article | Year |
|---|---|
High-level stable expression of recombinant 5-HT1A 5-hydroxytryptamine receptors in Chinese hamster ovary cells.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Binding, Competitive; Blotting, Northern; Cattle; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Gene Expression; Guanosine Triphosphate; Hippocampus; Humans; Receptors, Serotonin; Recombinant Proteins; Tetrahydronaphthalenes; Transfection | 1992 |
5-HT1A-receptor antagonism: N-alkyl derivatives of (R)-(-)-8,11-dimethoxynoraporphine.
Topics: Animals; Aporphines; Behavior, Animal; Cats; Chemical Phenomena; Chemistry; Dopamine Agents; Hemodynamics; In Vitro Techniques; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Stereoisomerism | 1989 |
Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor.
Topics: Animals; Computer Graphics; In Vitro Techniques; Ligands; Molecular Conformation; Rats; Receptors, Serotonin; Serotonin Antagonists; Stereoisomerism; Structure-Activity Relationship | 1988 |
Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.
Topics: Adenylyl Cyclases; Base Sequence; Cloning, Molecular; DNA Primers; Humans; Molecular Sequence Data; Receptors, Serotonin; Sequence Alignment; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction | 1993 |
Synthesis of (R,S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetral in (trans-8-OH-PIPAT): a new 5-HT1A receptor ligand.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Iodine Radioisotopes; Ligands; Rats; Receptors, Serotonin; Stereoisomerism; Tetrahydronaphthalenes; Tritium | 1993 |
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Cyclic AMP; DNA; Drosophila; Enzyme Activation; Humans; Intestinal Mucosa; Mice; Molecular Sequence Data; Myocardium; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; CHO Cells; Cricetinae; Cyclic AMP; DNA; Genomic Library; Kinetics; Lysergic Acid Diethylamide; Mianserin; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; Organ Specificity; Rats; Receptors, Serotonin; Restriction Mapping; Serotonin; Serotonin Receptor Agonists; Transfection | 1993 |
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Temperature | 1993 |
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
Topics: Adenylyl Cyclases; Animals; Behavior, Animal; Binding, Competitive; Colforsin; Cyclic AMP; Electrophysiology; Enzyme Activation; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Piperazines; Protein Binding; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Stereoisomerism; Structure-Activity Relationship | 1997 |
Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b).
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cyclic AMP; DNA, Complementary; Humans; Molecular Sequence Data; Placenta; Radioligand Assay; Rats; Receptors, Serotonin; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid | 1997 |
Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Affinity Labels; Animals; Binding, Competitive; CHO Cells; Cricetinae; Guanine Nucleotides; Hippocampus; Humans; Male; Membranes; Piperazines; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1998 |
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes | 1998 |
The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution.
Topics: Adenylyl Cyclases; Alternative Splicing; Binding, Competitive; Brain; Cell Line; Cloning, Organism; Genetic Variation; Humans; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tissue Distribution | 2001 |
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
Topics: Binding Sites; Binding, Competitive; Cell Line; Humans; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2004 |
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.
Topics: Amides; Animals; Cell Line; Guinea Pigs; Humans; Ileum; Male; Muscle Contraction; Muscle, Smooth; Piperazines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists; Structure-Activity Relationship; Tetrahydronaphthalenes | 2007 |
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation.
Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG | 2008 |
Pharmacological characterisation of the 5-HT1A serotonin receptor using the agonist [3H]8-OH-DPAT, and the antagonist [3H]spiperone.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; CHO Cells; Cricetinae; Humans; Kinetics; Lisuride; Methiothepin; Pindolol; Receptors, Serotonin; Recombinant Proteins; Serotonin; Serotonin Antagonists; Spiperone; Transfection; Tritium | 1992 |
Contractile effects of 8-hydroxy-2-(di-n-propylamino)tetralin and flesinoxan in human isolated basilar artery.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Antihypertensive Agents; Basilar Artery; Humans; In Vitro Techniques; Indoles; Methiothepin; Muscle Contraction; Muscle, Smooth, Vascular; Phentolamine; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Sulfonamides; Sumatriptan; Tetrahydronaphthalenes; Vasoconstrictor Agents | 1991 |
Vascular 5-HT1-like receptors that mediate contraction of the dog isolated saphenous vein and carotid arterial vasoconstriction in anaesthetized dogs are not of the 5-HT1A or 5-HT1D subtype.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Atropine; Carotid Arteries; Dogs; Ganglionic Blockers; In Vitro Techniques; Indoles; Ketanserin; Methiothepin; Muscle, Smooth, Vascular; Pyrilamine; Receptors, Serotonin; Saphenous Vein; Spiperone; Sulfonamides; Sumatriptan; Tetrahydronaphthalenes; Vasoconstriction; Vasoconstrictor Agents | 1991 |
ACTH/MSH-like peptides inhibit the binding of dopaminergic ligands to the dopamine D2 receptor in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Amino Acid Sequence; Animals; Apomorphine; Cosyntropin; Dopamine Agents; In Vitro Techniques; Kinetics; Ligands; Male; Melanocyte-Stimulating Hormones; Molecular Sequence Data; Peptide Fragments; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Structure-Activity Relationship; Tetrahydronaphthalenes | 1991 |
Sympatholytic action of yohimbine mediated by 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cats; Clonidine; Heart Rate; Injections, Intravenous; Receptors, Serotonin; Spiperone; Sympathetic Nervous System; Tetrahydronaphthalenes; Yohimbine | 1991 |
Ventrolateral medulla: an important site of action for the hypotensive effect of drugs that activate serotonin-1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Topical; Animals; Blood Pressure; Cats; Female; Heart Rate; Injections; Male; Medulla Oblongata; Microinjections; Receptors, Serotonin; Respiration; Serotonin Antagonists; Spiperone; Tetrahydronaphthalenes; Tidal Volume | 1990 |
Conditioned reinforcing effects of 8-hydroxy-2-(di-N-propylamino) tetralin: involvement of 5-hydroxytryptamine 1A and D1 dopamine receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzazepines; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Motivation; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Sulpiride; Tetrahydronaphthalenes | 1991 |
BMY 7378 is an agonist at 5-HT1A receptors mediating hypotension and renal sympatho-inhibition in anaesthetised cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Blood Pressure; Cats; Female; Heart Rate; Kidney; Male; Piperazines; Receptors, Serotonin; Spiperone; Sympathetic Nervous System; Sympatholytics; Tetrahydronaphthalenes | 1991 |
Recovery of 5-HT 1A receptors after irreversible blockade by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ).
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alkylating Agents; Animals; Autoradiography; Brain; Hippocampus; Quinolines; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes | 1991 |
Response of cerebellar Purkinje cells to serotonin and the 5-HT1A agonists 8-OH-DPAT and ipsapirone in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Cerebellum; Iontophoresis; Male; Naphthalenes; Purkinje Cells; Pyrimidines; Rats; Rats, Inbred Strains; Serotonin; Spiperone; Tetrahydronaphthalenes | 1990 |
Hypotensive effects of 8-hydroxy-2-(di-n-propylamino)tetralin and 5-methylurapidil following stereotaxic microinjection into the ventral medulla of the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Blood Pressure; Dioxanes; Dopamine Antagonists; Heart Rate; Male; Medulla Oblongata; Microinjections; Naphthalenes; Piperazines; Prazosin; Rats; Rats, Inbred Strains; Spiperone; Spiro Compounds; Stereotaxic Techniques; Tetrahydronaphthalenes | 1990 |
Synthesis and pharmacology of the enantiomers of cis-7-hydroxy-3-methyl-2-(dipropylamino)tetralin.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Binding, Competitive; Cattle; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Crystallography; Dihydroxyphenylalanine; Dopamine Antagonists; In Vitro Techniques; Isomerism; Male; Molecular Conformation; Molecular Structure; Motor Activity; Rats; Reserpine; Spiperone; Structure-Activity Relationship; Tetrahydronaphthalenes; X-Ray Diffraction | 1990 |
A pharmacological analysis of the eating response induced by 8-OH-DPAT injected into the dorsal raphé nucleus reveals the involvement of a dopaminergic mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dopamine; Drug Interactions; Eating; Haloperidol; Injections; Male; Metergoline; Naphthalenes; Propranolol; Raphe Nuclei; Rats; Rats, Inbred Strains; Spiperone; Tetrahydronaphthalenes | 1990 |
5-Hydroxytryptamine receptor agonists influence calcium-stimulated adenylate cyclase activity in the cerebral cortex and hippocampus of the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Calcium; Cerebral Cortex; Enzyme Activation; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes | 1990 |
Serotonin-mediated inhibitory postsynaptic potential in guinea-pig prepositus hypoglossi and feedback inhibition by serotonin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Brain Stem; Dose-Response Relationship, Drug; Feedback; Guinea Pigs; Hypoglossal Nerve; In Vitro Techniques; Male; Neurons; Piperazines; Potassium; Serotonin; Spiperone; Synapses; Tetrahydronaphthalenes; Time Factors | 1990 |
Changes in membrane potential of frog motoneurons induced by activation of serotonin receptor subtypes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Membrane Potentials; Motor Neurons; Pyrimidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spinal Cord; Spiperone; Tetrahydronaphthalenes | 1990 |
An in vitro study of the effects of serotonin on frog primary afferent terminals.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; In Vitro Techniques; Membrane Potentials; Neurons, Afferent; Ranidae; Serotonin; Serotonin Antagonists; Spinal Cord; Spiperone; Tetrahydronaphthalenes | 1990 |
The behavioural, but not the hypothermic or corticosterone, response to 8-hydroxy-2-(DI-n-propylamino)-tetralin, is antagonized by NAN-190 in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Body Temperature; Corticosterone; Male; Naphthalenes; Pindolol; Piperazines; Rats; Rats, Inbred Strains; Reserpine; Serotonin Antagonists; Spiperone; Tetrahydronaphthalenes | 1990 |
Do functional relationships exist between 5-HT1A and 5-HT2 receptors?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Ketanserin; Male; Methoxydimethyltryptamines; Mice; Mice, Inbred ICR; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Stereoisomerism; Tetrahydronaphthalenes | 1990 |
Studies on the site and mechanism of the sympatholytic action of 8-OH DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Medulla Oblongata; Neurons; Reference Values; Serotonin; Spinal Cord; Spiperone; Sympathetic Nervous System; Sympatholytics; Tetrahydronaphthalenes | 1990 |
Electrophysiological assessment of putative antagonists of 5-hydroxytryptamine receptors: a single-cell study in the rat dorsal raphe nucleus.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Electrophysiology; Lysergic Acid Diethylamide; Male; Methiothepin; Neurons; Propranolol; Quinazolines; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin Antagonists; Spiperone; Tetrahydronaphthalenes | 1989 |
Induction of purposeless chewing behaviour in rats by 5-HT agonist drugs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Male; Methiothepin; Methoxydimethyltryptamines; Mianserin; Parasympatholytics; Piperazines; Propranolol; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes | 1989 |
Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Affinity Labels; Azides; Cell Line; Humans; Iodine Radioisotopes; Precipitin Tests; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes | 1989 |
Importance of central nervous system serotonin-1A receptors for mediating the hypotensive effect of urapidil.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antihypertensive Agents; Blood Pressure; Cats; Heart Rate; Medulla Oblongata; Piperazines; Prazosin; Receptors, Serotonin; Respiration; Spiperone; Tetrahydronaphthalenes | 1989 |
The relaxation induced by indole and nonindole 5-HT agonists in the molluscan smooth muscle.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bivalvia; Cyclic AMP; In Vitro Techniques; Indoles; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Pindolol; Propranolol; Proteins; Serotonin; Spiperone; Tetrahydronaphthalenes | 1988 |
Spiperone differentiates multiple 5-hydroxytryptamine responses in rat hippocampal slices in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Butyrophenones; Hippocampus; In Vitro Techniques; Ketanserin; Piperidines; Rats; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes | 1985 |
[3H]1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine: a selective radioligand for 5-HT1A receptors in rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Cerebellum; Cerebral Cortex; Chemical Phenomena; Chemistry; Corpus Striatum; Hippocampus; Kinetics; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone; Tetrahydronaphthalenes | 1986 |
Dissociation constants of serotonin agonists in the canine basilar artery correlate to Ki values at the 5-HT1A binding site.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Basilar Artery; Binding Sites; Binding, Competitive; Dogs; Female; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone; Tetrahydronaphthalenes; Tritium | 1986 |
Inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT receptor agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Tetrahydronaphthalenes | 1985 |
Possible 5-hydroxytryptamine1 (5-HT1) receptor involvement in the stimulus properties of 1-(m-trifluoromethylphenyl)piperazine (TFMPP).
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Indoles; Lysergic Acid Diethylamide; Male; Metergoline; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes | 1986 |
Canine basilar artery contractions mediated by 5-hydroxytryptamine1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Basilar Artery; Dogs; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Lysergic Acid Diethylamide; Piperidines; Rats; Receptors, Serotonin; Serotonin; Spiperone; Tetrahydronaphthalenes; Tritium; Vasoconstriction | 1986 |
Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature Regulation; Ketanserin; Male; Methoxydimethyltryptamines; Pindolol; Piperidines; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes | 1986 |
Pharmacological characterization of two 5-hydroxytryptamine receptors coupled to adenylate cyclase in guinea pig hippocampal membranes.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Bufotenin; Guinea Pigs; Hippocampus; Kinetics; Male; Mathematics; Membranes; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone; Tetrahydronaphthalenes; Tryptamines | 1987 |
Stimulation of corticosterone and beta-endorphin secretion in the rat by selective 5-HT receptor subtype activation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; beta-Endorphin; Corticosterone; Endorphins; Ketanserin; Male; Pindolol; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Tetrahydronaphthalenes | 1987 |
Photoaffinity labelling and solubilization on the central 5-HT1A receptor binding site.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Affinity Labels; Animals; Azides; Binding Sites; Cations; Detergents; Guanylyl Imidodiphosphate; Hippocampus; Male; Photolysis; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Solubility; Spiperone; Tetrahydronaphthalenes | 1987 |
[3H]spiroxatrine labels a serotonin1A-like site in the rat hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Cell Membrane; Dioxanes; Dioxins; Dopamine; Guanosine Triphosphate; Haloperidol; Hippocampus; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone; Spiro Compounds; Tetrahydronaphthalenes; Tritium | 1987 |
A pharmacological analysis of the rat spinal cord serotonin (5-HT) autoreceptor.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Ergolines; Male; Piperazines; Potassium; Quipazine; Rats; Receptors, Serotonin; Serotonin; Spinal Cord; Spiperone; Tetrahydronaphthalenes; Tritium | 1988 |
Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamine; Animals; Buspirone; Dopamine; Electrodes; Electrophysiology; Male; Neurons; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Spiperone; Tetrahydronaphthalenes | 1988 |
Evidence for 5-HT1A binding sites in chick embryo brain and discrimination by 5-methoxytryptamine.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Brain Chemistry; Chick Embryo; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes; Tryptamines | 1987 |
Serotonin-induced reduction of the calcium-dependent plateau in frog dorsal root ganglion cells is blocked by serotonergic agents acting at 5-hydroxytryptamine1A sites.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Calcium; Dioxanes; Ganglia, Spinal; Methiothepin; Rana catesbeiana; Receptors, Serotonin; Serotonin; Spiperone; Spiro Compounds; Tetrahydronaphthalenes | 1988 |
Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Binding Sites; Blood Pressure; In Vitro Techniques; Indoles; Male; Naphthalenes; Pentobarbital; Pindolol; Rats; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes | 1985 |
Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-n-propylamino)tetralin) in the rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Brain; Brain Chemistry; Cerebral Cortex; Female; Hydroxyindoleacetic Acid; In Vitro Techniques; Membranes; Naphthalenes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Spiperone; Synaptosomes; Tetrahydronaphthalenes; Tryptophan Hydroxylase | 1984 |
Influences of housing conditions and ethanol intake on binding characteristics of D2, 5-HT1A, and benzodiazepine receptors of rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Flunitrazepam; Hippocampus; Kinetics; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, GABA-A; Receptors, Serotonin; Social Isolation; Spiperone | 1995 |
8-OH-DPAT-induced hypotensive action and sympathoexcitatory neurons in the rostral ventrolateral medulla of the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Buspirone; Heart Rate; Hypotension; Male; Medulla Oblongata; Norepinephrine; Rats; Rats, Wistar; Spiperone | 1995 |
Single-unit responses of serotonergic dorsal raphe neurons to 5-HT1A agonist and antagonist drug administration in behaving cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Cats; Depression, Chemical; Dopamine D2 Receptor Antagonists; Female; Haloperidol; Male; Membrane Potentials; Neurons; Premedication; Raphe Nuclei; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone | 1994 |
Long-term in vivo desipramine or estrogen treatment fails to affect serotonin-induced outward current in hippocampal pyramidal cells of the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Desipramine; Electric Stimulation; Electrophysiology; Estradiol; Estrogens; Female; Hippocampus; In Vitro Techniques; Male; Orchiectomy; Ovariectomy; Potassium Chloride; Pyramidal Cells; Rats; Rats, Wistar; Serotonin; Spiperone; Testosterone | 1994 |
Characterization of a cloned rat serotonin 5-HT1A receptor expressed in the HeLa cell line.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Binding, Competitive; Cloning, Molecular; Guanosine Triphosphate; HeLa Cells; Humans; Rats; Receptors, Serotonin; Serotonin Receptor Agonists; Spiperone; Transfection | 1993 |
Whole-cell recordings of inwardly rectifying K+ currents activated by 5-HT1A receptors on dorsal raphe neurones of the adult rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Barium; Cyclic AMP; Electrophysiology; Glyburide; In Vitro Techniques; Ion Channel Gating; Masoprocol; Membrane Potentials; Neurons; Pertussis Toxin; Potassium; Potassium Channels; Raphe Nuclei; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Tolbutamide; Virulence Factors, Bordetella | 1993 |
Involvement of the serotonergic system in the hypoactive and antinociceptive effects of nicotine in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Ketanserin; Locomotion; Male; Mice; Mice, Inbred ICR; Nicotine; Nociceptors; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone | 1994 |
Mixed 5-HT1A/D-2 activity of a new model of arylpiperazines: 1-aryl-4-[3-(1,2-dihydronaphthalen-4-yl)-n-propyl]piperazines. 1. Synthesis and structure-activity relationships.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cell Membrane; Cerebral Cortex; Corpus Striatum; Ketanserin; Male; Molecular Structure; Naphthalenes; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Serotonin; Spiperone; Structure-Activity Relationship; Tritium | 1994 |
Delayed effects of spiperone on serotonin1A receptors in the dorsal hippocampus of rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Culture Techniques; GTP-Binding Proteins; Hippocampus; Male; Methiothepin; Raphe Nuclei; Rats; Receptors, Serotonin; Spiperone; Synapses | 1993 |
Characterization of the serotonin1A receptor antagonist activity of WAY-100135 and spiperone.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cats; Membrane Potentials; Neurons; Piperazines; Serotonin Antagonists; Spiperone | 1994 |
Positron emission tomography studies on some neurotransmitter receptor systems with 6R-tetrahydrobiopterin pretreatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzazepines; Benztropine; Biopterins; Brain; Carbon Radioisotopes; Dopamine Antagonists; Glucose; Macaca mulatta; Nicotine; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Neurotransmitter; Regional Blood Flow; Spiperone; Tomography, Emission-Computed | 1993 |
Positron emission tomography (PET) study: the effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP, SUN 0588) on the central dopamine D1, D2 and D3 receptors in rhesus monkey.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzazepines; Biopterins; Brain; Carbon Radioisotopes; Corpus Striatum; Dopamine Antagonists; Frontal Lobe; Kinetics; Macaca mulatta; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Spiperone; Tomography, Emission-Computed | 1993 |
Serotonin-mediated 5-HT2 receptor gene regulation in rat myometrial smooth muscle cells.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Biguanides; Cells, Cultured; Cycloheximide; Female; Gene Expression Regulation; Ketanserin; Medroxyprogesterone Acetate; Myometrium; Piperazines; Quipazine; Rats; Receptors, Serotonin; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Sulpiride; Transcription, Genetic; Up-Regulation | 1993 |
Activation of serotonin1A receptors inhibits midbrain periaqueductal gray neurons of the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cell Membrane; In Vitro Techniques; Male; Membrane Potentials; Mesencephalon; Neurons; Periaqueductal Gray; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Spiperone; Synapses | 1993 |
Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1A receptors that are negatively coupled to adenylate cyclase in permanently transfected HeLa cells.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Colforsin; Cyclic AMP; HeLa Cells; Humans; Indoles; Lysergic Acid Diethylamide; Models, Biological; Pindolol; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Transfection | 1993 |
Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Base Sequence; Calcium; Cells, Cultured; Cyclic AMP; Gene Expression; Humans; In Vitro Techniques; Inositol Phosphates; Lymphocyte Activation; Molecular Sequence Data; Oligodeoxyribonucleotides; Receptors, Serotonin; RNA, Messenger; Serotonin; Signal Transduction; Spiperone; T-Lymphocytes | 1993 |
Characterization of recombinant human serotonin 5HT1A receptors expressed in Chinese hamster ovary cells. [3H]spiperone discriminates between the G-protein-coupled and -uncoupled forms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; CHO Cells; Cricetinae; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Radioligand Assay; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Spiperone; Tritium | 1993 |
Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Drug Antagonism; gamma-Aminobutyric Acid; Hippocampus; Male; Methiothepin; Neurons; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Synapses | 1993 |
Effects of bulbectomy and subsequent antidepressant treatment on brain 5-HT2 and 5-HT1A receptors in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Brain Chemistry; Down-Regulation; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Olfactory Bulb; Radioligand Assay; Receptors, Serotonin; Spiperone | 1993 |
8-OH-DPAT stimulates gastric acid secretion through a vagal-independent, adrenal-mediated mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenal Glands; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dopamine Antagonists; Ganglia, Sympathetic; Gastric Acid; Gastric Acidity Determination; Idazoxan; Imidazoles; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Spiperone; Splenic Artery; Stimulation, Chemical; Vagotomy; Vagus Nerve | 1995 |
Resolution of multiple affinity states of 5-hydroxytryptamine-1A receptors labelled by [3H]-8-hydroxy-2-(di-n-propilamino) tetralin in rat hippocampal membranes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Dopamine Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; In Vitro Techniques; Membranes; Rats; Receptors, Serotonin; Serotonin Receptor Agonists; Spiperone; Thermodynamics | 1996 |
5-HT1A-versus D2-receptor selectivity of flesinoxan and analogous N4-substituted N1-arylpiperazines.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Brain; CHO Cells; Cricetinae; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Piperazines; Protein Binding; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Spiperone; Structure-Activity Relationship | 1997 |
Structure-affinity relationship studies on D-2/5-HT1A receptor ligands. 4-(2-Heteroarylethyl)-1-arylpiperazines.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzazepines; Cattle; Caudate Nucleus; Chemical Phenomena; Chemistry, Physical; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Hippocampus; In Vitro Techniques; Ligands; Piperazines; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Spiperone; Structure-Activity Relationship; Synaptosomes | 1997 |
The effect of streptozotocin-induced diabetes on dopamine2, serotonin1A and serotonin2A receptors in the rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Diabetes Mellitus, Experimental; Dopamine Antagonists; Frontal Lobe; Haloperidol; Hippocampus; Ketanserin; Male; Neostriatum; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Streptozocin | 1997 |
Desensitization of spinal 5-HT1A receptors to 8-OH-DPAT: an in vivo spinal reflex study.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Male; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex; Serotonin Antagonists; Spinal Cord; Spiperone; Synapses; Time Factors | 1997 |
Serotonin reduces synaptic excitation in the superficial medial entorhinal cortex of the rat via a presynaptic mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bicuculline; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Female; Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Male; Patch-Clamp Techniques; Piperazines; Potassium Channels; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Synapses; Synaptic Transmission; Tetrodotoxin | 1998 |
Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Injections, Intraventricular; Inositol Phosphates; Ketanserin; Male; Mice; Motor Activity; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Tryptamines; Xanthenes; Xanthones | 1998 |
5-Hydroxytryptamine responses in immature rat rostral ventrolateral medulla neurons in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dopamine Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine Diphosphate; Ketanserin; Medulla Oblongata; Membrane Potentials; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Synaptic Transmission; Thionucleotides | 1998 |
Effect of acute, short- and long-term milnacipran administration on rat locus coeruleus noradrenergic and dorsal raphe serotonergic neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Biological Transport; Brimonidine Tartrate; Clonidine; Cyclopropanes; Desipramine; Drug Administration Schedule; gamma-Aminobutyric Acid; Hippocampus; Hypothalamus; Injections, Subcutaneous; Kinetics; Locus Coeruleus; Lysergic Acid Diethylamide; Male; Mesencephalon; Milnacipran; Neurons; Norepinephrine; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Spiperone; Time Factors | 1998 |
Modification of sexual behavior of Long-Evans male rats by drugs acting on the 5-HT1A receptor.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain Chemistry; Buspirone; Copulation; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Penile Erection; Penis; Piperazines; Pyrimidines; Rats; Rats, Long-Evans; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex; Serotonin; Serotonin Receptor Agonists; Spiperone | 1999 |
Serotonergic modulation of hyperpolarization-activated current in acutely isolated rat dorsal root ganglion neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Cell Size; Cyclic Nucleotide-Gated Cation Channels; Dopamine Antagonists; Ganglia, Spinal; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Neurons, Afferent; Patch-Clamp Techniques; Pindolol; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reverse Transcriptase Polymerase Chain Reaction; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone | 1999 |
8OH-DPAT-Induced ocular hypotension: sites and mechanisms of action.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Ciliary Body; Cyclic AMP; Dioxanes; Dopamine Antagonists; Dose-Response Relationship, Drug; Intraocular Pressure; Iris; Norepinephrine; Ocular Hypertension; Rabbits; Serotonin Receptor Agonists; Spiperone; Spiro Compounds | 1999 |
Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Braces; Carotid Arteries; Dose-Response Relationship, Drug; Hypersensitivity; In Vitro Techniques; Ketanserin; Male; Methysergide; Oxadiazoles; Piperazines; Potassium Chloride; Rabbits; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Sumatriptan; Tryptamines; Vasoconstriction | 1999 |
Auditory evoked potentials reflect serotonergic neuronal activity--a study in behaving cats administered drugs acting on 5-HT1A autoreceptors in the dorsal raphe nucleus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Auditory Cortex; Cats; Dopamine Agonists; Dopamine Antagonists; Evoked Potentials, Auditory; Neurons; Raphe Nuclei; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Spiperone | 1999 |
PD 158771, a potential antipsychotic agent with D(2)/D(3) partial agonist and 5-HT(1A) agonist actions. I. Neurochemical effects.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Benzazepines; Biogenic Amines; Brain Chemistry; Cells, Cultured; CHO Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Electrophysiology; Humans; Male; Membranes; Neostriatum; Piperazines; Pyrimidines; Rats; Rats, Long-Evans; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Spiperone; Tetrahydronaphthalenes; Thiophenes | 2000 |
5-HT(1A) receptor agonist-antagonist binding affinity difference as a measure of intrinsic activity in recombinant and native tissue systems.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone | 2000 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study).
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Male; Microdialysis; Rats; Rats, Wistar; Receptors, Dopamine D3; Spiperone; Tetrahydronaphthalenes | 2001 |
New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D(2)-receptor and serotonin 5-HT(1A)-receptor affinities.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzoxazoles; Dopamine Antagonists; Drug Design; Drug Evaluation, Preclinical; Mice; Piperazines; Rats; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Spiperone; Structure-Activity Relationship | 2001 |
Direct activation by dopamine of recombinant human 5-HT1A receptors: comparison with human 5-HT2C and 5-HT3 receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Chelating Agents; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanosine Diphosphate; Haloperidol; Humans; Indazoles; Inhibitory Concentration 50; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Pertussis Toxin; Piperazine; Piperazines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT2; Receptors, Serotonin, 5-HT3; Recombinant Proteins; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Thionucleotides; Tropanes; Xenopus laevis | 2003 |