Page last updated: 2024-08-16

spiperone and 5-carboxamidotryptamine

spiperone has been researched along with 5-carboxamidotryptamine in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19905 (15.15)18.7374
1990's22 (66.67)18.2507
2000's6 (18.18)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Newman-Tancredi, A; Strange, PG; Wootton, R1
Amlaiky, N; Boschert, U; Hen, R; Maroteaux, L; Plassat, JL; Saudou, F1
Branchek, TA; Hartig, PR; Macchi, MJ; Weinshank, RL; Zgombick, JM1
Hamblin, MW; Metcalf, MA1
Glennon, RA2
Buckingham, J; Glen, RC; Hill, AP; Hyde, RM; Martin, GR; Robertson, AD; Salmon, JA; Woollard, PM1
Baez, M; Kursar, JD; Nelson, DL; Wainscott, DB1
Adham, N; Bard, JA; Branchek, TA; Vaysse, P; Weinshank, RL; Zgombick, J1
Amlaiky, N; Hen, R; Plassat, JL1
Arrang, JM; Diaz, J; Leurs, R; Ruat, M; Schwartz, JC; Tardivel-Lacombe, J; Traiffort, E1
Audia, JE; Baez, M; Cohen, ML; Kursar, JD; Lucaites, VL; Nelson, DL; Nissen, JS; Schenck, KW; Wainscott, DB1
Chang, DJ; Eglen, RM; Jasper, JR; Kosaka, A; To, ZP1
Chaput, C; Millan, MJ; Newman-Tancredi, A; Verrièle, L1
Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L1
Bach, T; Krobert, KA; Kvingedal, AM; Levy, FO; Syversveen, T1
Benwell, K; Bickerdike, M; Kennett, G; Knight, AR; Misra, A; Quirk, K; Revell, D1
Berardi, F; Colabufo, NA; Contino, M; Lacivita, E; Leopoldo, M; Perrone, R1
Cleves, AE; Jain, AN; Kirshner, D; Langham, JJ; Spitzer, R1
Esterle, TM; Sanders-Bush, E1
Bobker, DH; Williams, JT1
Feniuk, W; Humphrey, PP; Perren, MJ; Watts, AD1
Devivo, M; Maayani, S1
Green, JP; Maayani, S; Shenker, A; Weinstein, H2
Chiba, S; Vhora, S1
Adham, N; Bard, J; Branchek, TA; Durkin, M; Hartig, PR; Kao, HT; Olsen, M; Schecter, LE; Urquhart, D; Weinshank, RL1
Chaput, C; Conte, C; Millan, MJ; Newman-Tancredi, A; Spedding, M1
Draguhn, A; Empson, RM; Gloveli, T; Heinemann, U; Schmitz, D1
Arnold, PB; Cardenas, CG; Cardenas, LM; Mar, LP; Scroggs, RS; Surmeier, DJ; Vysokanov, AV1
Falcón-Neri, A; Terrón, JA1
Bult, H; Geerts, IS; Herman, AG; Matthys, KE1
Cosi, C; Koek, W1

Reviews

2 review(s) available for spiperone and 5-carboxamidotryptamine

ArticleYear
Central serotonin receptors as targets for drug research.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:1

    Topics: Animals; Humans; Receptors, Serotonin; Research Design; Serotonin

1987
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
    Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14

    Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists

2003

Other Studies

31 other study(ies) available for spiperone and 5-carboxamidotryptamine

ArticleYear
High-level stable expression of recombinant 5-HT1A 5-hydroxytryptamine receptors in Chinese hamster ovary cells.
    The Biochemical journal, 1992, Aug-01, Volume: 285 ( Pt 3)

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Binding, Competitive; Blotting, Northern; Cattle; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Gene Expression; Guanosine Triphosphate; Hippocampus; Humans; Receptors, Serotonin; Recombinant Proteins; Tetrahydronaphthalenes; Transfection

1992
Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Apr-01, Volume: 89, Issue:7

    Topics: 3T3 Cells; Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Cerebellum; Corpus Striatum; Gene Expression; Genes; GTP-Binding Proteins; Mice; Molecular Sequence Data; Nucleic Acid Hybridization; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Purkinje Cells; Receptors, Serotonin; RNA, Messenger; Serotonin

1992
Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Apr-15, Volume: 89, Issue:8

    Topics: Amino Acid Sequence; Animals; Brain; Cattle; Cell Membrane; Cloning, Molecular; DNA Probes; Female; Gene Library; Humans; Kinetics; Molecular Sequence Data; Multigene Family; Placenta; Pregnancy; Receptors, Serotonin; Recombinant Proteins; Sequence Homology, Nucleic Acid

1992
Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.
    Molecular pharmacology, 1991, Volume: 40, Issue:2

    Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cyclic AMP; GTP-Binding Proteins; Humans; Molecular Sequence Data; Pertussis Toxin; Receptors, Serotonin; Virulence Factors, Bordetella

1991
Computer-aided design and synthesis of 5-substituted tryptamines and their pharmacology at the 5-HT1D receptor: discovery of compounds with potential anti-migraine properties.
    Journal of medicinal chemistry, 1995, Sep-01, Volume: 38, Issue:18

    Topics: Animals; Aorta; Computer-Aided Design; Drug Design; Haplorhini; In Vitro Techniques; Migraine Disorders; Models, Chemical; Rabbits; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Saphenous Vein; Serotonin Receptor Agonists; Structure-Activity Relationship; Tryptamines

1995
Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor.
    Molecular pharmacology, 1994, Volume: 46, Issue:2

    Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; DNA, Complementary; Humans; Molecular Sequence Data; Open Reading Frames; Protein Conformation; Rats; Receptor, Serotonin, 5-HT2B; Receptors, Serotonin; RNA, Messenger; Sequence Homology, Amino Acid; Tissue Distribution

1994
Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.
    The Journal of biological chemistry, 1993, Nov-05, Volume: 268, Issue:31

    Topics: Adenylyl Cyclases; Base Sequence; Cloning, Molecular; DNA Primers; Humans; Molecular Sequence Data; Receptors, Serotonin; Sequence Alignment; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction

1993
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
    Molecular pharmacology, 1993, Volume: 44, Issue:2

    Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Cyclic AMP; DNA; Drosophila; Enzyme Activation; Humans; Intestinal Mucosa; Mice; Molecular Sequence Data; Myocardium; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists

1993
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Sep-15, Volume: 90, Issue:18

    Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; CHO Cells; Cricetinae; Cyclic AMP; DNA; Genomic Library; Kinetics; Lysergic Acid Diethylamide; Mianserin; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; Organ Specificity; Rats; Receptors, Serotonin; Restriction Mapping; Serotonin; Serotonin Receptor Agonists; Transfection

1993
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
    Molecular pharmacology, 1993, Volume: 43, Issue:3

    Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Temperature

1993
Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b).
    British journal of pharmacology, 1997, Volume: 122, Issue:1

    Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cyclic AMP; DNA, Complementary; Humans; Molecular Sequence Data; Placenta; Radioligand Assay; Rats; Receptors, Serotonin; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid

1997
Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists.
    Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Affinity Labels; Animals; Binding, Competitive; CHO Cells; Cricetinae; Guanine Nucleotides; Hippocampus; Humans; Male; Membranes; Piperazines; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists

1998
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
    European journal of pharmacology, 1998, Aug-21, Volume: 355, Issue:2-3

    Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes

1998
The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution.
    Naunyn-Schmiedeberg's archives of pharmacology, 2001, Volume: 363, Issue:6

    Topics: Adenylyl Cyclases; Alternative Splicing; Binding, Competitive; Brain; Cell Line; Cloning, Organism; Genetic Variation; Humans; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tissue Distribution

2001
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 370, Issue:2

    Topics: Binding Sites; Binding, Competitive; Cell Line; Humans; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists

2004
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.
    Journal of medicinal chemistry, 2007, Aug-23, Volume: 50, Issue:17

    Topics: Amides; Animals; Cell Line; Guinea Pigs; Humans; Ileum; Male; Muscle Contraction; Muscle, Smooth; Piperazines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists; Structure-Activity Relationship; Tetrahydronaphthalenes

2007
Physical binding pocket induction for affinity prediction.
    Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19

    Topics: Binding Sites; Ligands; Models, Molecular; Neural Networks, Computer; Peptide Fragments; Protein Binding; Receptor, Serotonin, 5-HT1A

2009
Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:12

    Topics: Amino Acid Isomerases; Animals; Blotting, Northern; Carrier Proteins; Cells, Cultured; Choroid Plexus; Cyclosporins; Epithelium; Ergolines; Fibroblasts; Kinetics; Male; Mianserin; Peptidylprolyl Isomerase; Phosphatidylinositols; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; RNA Probes; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Thymidine; Time Factors; Transferrin

1992
Serotonin-mediated inhibitory postsynaptic potential in guinea-pig prepositus hypoglossi and feedback inhibition by serotonin.
    The Journal of physiology, 1990, Volume: 422

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Brain Stem; Dose-Response Relationship, Drug; Feedback; Guinea Pigs; Hypoglossal Nerve; In Vitro Techniques; Male; Neurons; Piperazines; Potassium; Serotonin; Spiperone; Synapses; Tetrahydronaphthalenes; Time Factors

1990
A comparison of 5-hydroxytryptamine receptors mediating contraction in rabbit aorta and dog saphenous vein: evidence for different receptor types obtained by use of selective agonists and antagonists.
    British journal of pharmacology, 1985, Volume: 86, Issue:3

    Topics: Animals; Aorta; Dogs; In Vitro Techniques; Ketanserin; Methoxamine; Muscle Contraction; Muscle, Smooth, Vascular; Piperidines; Rabbits; Receptors, Serotonin; Saphenous Vein; Serotonin; Serotonin Antagonists; Spiperone

1985
Inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT receptor agonists.
    European journal of pharmacology, 1985, Dec-17, Volume: 119, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Tetrahydronaphthalenes

1985
Pharmacological characterization of two 5-hydroxytryptamine receptors coupled to adenylate cyclase in guinea pig hippocampal membranes.
    Molecular pharmacology, 1987, Volume: 31, Issue:4

    Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Bufotenin; Guinea Pigs; Hippocampus; Kinetics; Male; Mathematics; Membranes; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone; Tetrahydronaphthalenes; Tryptamines

1987
Two 5-HT receptors linked to adenylate cyclase in guinea pig hippocampus are discriminated by 5-carboxamidotryptamine and spiperone.
    European journal of pharmacology, 1985, Mar-12, Volume: 109, Issue:3

    Topics: Adenylyl Cyclases; Animals; Butyrophenones; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Receptors, Serotonin; Serotonin; Spiperone

1985
Functional 5-HT receptor subtypes in the isolated canine common carotid artery.
    Heart and vessels, 1994, Volume: 9, Issue:5

    Topics: Adrenergic alpha-Antagonists; Animals; Carotid Artery, Common; Diltiazem; Dogs; Female; Ketanserin; Male; Methysergide; Norepinephrine; Potassium Chloride; Quinazolines; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Spiperone; Vasoconstriction

1994
Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Jan-15, Volume: 90, Issue:2

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; Colforsin; Dose-Response Relationship, Drug; Gene Library; Guinea Pigs; Humans; Indoles; Lymphocytes; Molecular Sequence Data; Receptors, Serotonin; RNA, Messenger; Sequence Homology, Amino Acid; Serotonin; Serotonin Receptor Agonists; Spiperone; Sulfonamides; Sumatriptan; Tissue Distribution

1993
Inhibition of the constitutive activity of human 5-HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635.
    British journal of pharmacology, 1997, Volume: 120, Issue:5

    Topics: Animals; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Piperazines; Pyridines; Radioligand Assay; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Recombinant Proteins; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Sulfur Radioisotopes

1997
Serotonin reduces synaptic excitation in the superficial medial entorhinal cortex of the rat via a presynaptic mechanism.
    The Journal of physiology, 1998, Apr-01, Volume: 508 ( Pt 1)

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bicuculline; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Female; Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Male; Patch-Clamp Techniques; Piperazines; Potassium Channels; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Synapses; Synaptic Transmission; Tetrodotoxin

1998
Serotonergic modulation of hyperpolarization-activated current in acutely isolated rat dorsal root ganglion neurons.
    The Journal of physiology, 1999, Jul-15, Volume: 518 ( Pt 2)

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Cell Size; Cyclic Nucleotide-Gated Cation Channels; Dopamine Antagonists; Ganglia, Spinal; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Neurons, Afferent; Patch-Clamp Techniques; Pindolol; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reverse Transcriptase Polymerase Chain Reaction; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone

1999
Pharmacological evidence for the 5-HT7 receptor mediating smooth muscle relaxation in canine cerebral arteries.
    British journal of pharmacology, 1999, Volume: 127, Issue:3

    Topics: Animals; Basilar Artery; Cerebral Arteries; Dinoprost; Dogs; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Spiperone; Sumatriptan

1999
Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery.
    British journal of pharmacology, 1999, Volume: 127, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Braces; Carotid Arteries; Dose-Response Relationship, Drug; Hypersensitivity; In Vitro Techniques; Ketanserin; Male; Methysergide; Oxadiazoles; Piperazines; Potassium Chloride; Rabbits; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Sumatriptan; Tryptamines; Vasoconstriction

1999
The putative <> 5-HT(1A) receptor antagonist, WAY 100635, has inverse agonist properties at cloned human 5-HT(1A) receptors.
    European journal of pharmacology, 2000, Jul-28, Volume: 401, Issue:1

    Topics: Binding, Competitive; Cell Membrane; DNA, Recombinant; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Piperazines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sodium Chloride; Spiperone; Sulfur Radioisotopes

2000