Page last updated: 2024-08-16

spiperone and 4-iodo-2,5-dimethoxyphenylisopropylamine

spiperone has been researched along with 4-iodo-2,5-dimethoxyphenylisopropylamine in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.17)18.7374
1990's20 (83.33)18.2507
2000's3 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Adham, N; Branchek, T; Hartig, PR; Kao, HT; Macchi, M1
Glennon, RA; Herrick-Davis, K; Lyon, RA; Seggel, MR; Soine, WH; Titeler, M1
Baez, M; Kursar, JD; Nelson, DL; Wainscott, DB1
Audia, JE; Baez, M; Cohen, ML; Kursar, JD; Lucaites, VL; Nelson, DL; Nissen, JS; Schenck, KW; Wainscott, DB1
Mutel, V; Sleight, AJ; Stam, NJ; Vanderheyden, PM1
Kristiansen, K; Kroeze, WK; Roth, BL; Shapiro, DA1
Glennon, RA1
Cleves, AE; Jain, AN; Kirshner, D; Langham, JJ; Spitzer, R1
Jeffrey, JJ; Rydelek-Fitzgerald, L; Wilcox, BD1
Done, CJ; Sharp, T1
Beck, SG1
Ashby, CR; Wang, RY1
Darmani, NA; Glennon, RA; Martin, BR; Pandey, U1
Chaouche-Teyara, K; Dabiré, H; Fournier, B; Safar, M1
Bobker, DH1
Jeffrey, JJ; Rydelek-Fitzgerald, L; Teitler, M; Wilcox, BD2
Coulson, A; Grahame-Smith, DG; Leslie, RA; Moorman, JM1
Kagaya, A; Mikuni, M; Muraoka, S; Saitoh, K; Takahashi, K1
Grignaschi, G; Samanin, R; Sironi, F1
Aloyo, VJ; Harvey, JA; Hoffman, ME; Salt, GL1
Conklin, DS; Fitzgerald, LW; Hartig, PR; Iyer, G; Kostich, WA; Krause, CM; Largent, BL; Marshall, AP; Patterson, JP; Tran, DP1
Knowles, ID; Ramage, AG1
Currie, PJ; Saxena, N; Tu, AY1

Reviews

1 review(s) available for spiperone and 4-iodo-2,5-dimethoxyphenylisopropylamine

ArticleYear
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
    Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14

    Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists

2003

Other Studies

23 other study(ies) available for spiperone and 4-iodo-2,5-dimethoxyphenylisopropylamine

ArticleYear
[3H]-DOB(4-bromo-2,5-dimethoxyphenylisopropylamine) and [3H] ketanserin label two affinity states of the cloned human 5-hydroxytryptamine2 receptor.
    Molecular pharmacology, 1990, Volume: 38, Issue:5

    Topics: Affinity Labels; Animals; Binding Sites; Binding, Competitive; Cell Line; Chlorocebus aethiops; Cloning, Molecular; DOM 2,5-Dimethoxy-4-Methylamphetamine; Genetic Vectors; Guanylyl Imidodiphosphate; Ketanserin; Mice; Receptors, Serotonin; Transfection; Tritium

1990
[125I]-1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane: an iodinated radioligand that specifically labels the agonist high-affinity state of 5-HT2 serotonin receptors.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:1

    Topics: Amphetamines; Indicators and Reagents; Iodine Radioisotopes; Kinetics; Radioligand Assay; Receptors, Serotonin

1988
Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor.
    Molecular pharmacology, 1994, Volume: 46, Issue:2

    Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; DNA, Complementary; Humans; Molecular Sequence Data; Open Reading Frames; Protein Conformation; Rats; Receptor, Serotonin, 5-HT2B; Receptors, Serotonin; RNA, Messenger; Sequence Homology, Amino Acid; Tissue Distribution

1994
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
    Molecular pharmacology, 1993, Volume: 43, Issue:3

    Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Temperature

1993
Radiolabelling of the human 5-HT2A receptor with an agonist, a partial agonist and an antagonist: effects on apparent agonist affinities.
    Biochemical pharmacology, 1996, Jan-12, Volume: 51, Issue:1

    Topics: 3T3 Cells; Animals; Binding, Competitive; Cell Membrane; DOM 2,5-Dimethoxy-4-Methylamphetamine; Humans; Ketanserin; Mice; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Recombinant Proteins; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

1996
Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5.
    Molecular pharmacology, 2000, Volume: 58, Issue:5

    Topics: Amino Acid Substitution; Animals; Binding, Competitive; Conserved Sequence; COS Cells; DOM 2,5-Dimethoxy-4-Methylamphetamine; Hydrolysis; Membrane Proteins; Models, Molecular; Mutagenesis, Site-Directed; Phosphatidylinositols; Protein Folding; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Signal Transduction; Tryptamines

2000
Physical binding pocket induction for affinity prediction.
    Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19

    Topics: Binding Sites; Ligands; Models, Molecular; Neural Networks, Computer; Peptide Fragments; Protein Binding; Receptor, Serotonin, 5-HT1A

2009
Regulation of collagenase gene expression by serotonin and progesterone in rat uterine smooth muscle cells.
    The Journal of biological chemistry, 1992, Oct-15, Volume: 267, Issue:29

    Topics: Amphetamines; Animals; Cell Nucleus; Cells, Cultured; Collagenases; DNA Probes; Female; Gene Expression Regulation, Enzymologic; Ketanserin; Kinetics; Muscle, Smooth; Myometrium; Progesterone; Quipazine; Rats; Receptors, Serotonin; RNA, Messenger; Serotonin; Serotonin Antagonists; Spiperone; Tetradecanoylphorbol Acetate; Transcription, Genetic; Uterus

1992
Evidence that 5-HT2 receptor activation decreases noradrenaline release in rat hippocampus in vivo.
    British journal of pharmacology, 1992, Volume: 107, Issue:1

    Topics: Amphetamines; Animals; DOM 2,5-Dimethoxy-4-Methylamphetamine; Electrophysiology; Hippocampus; Male; Neurons; Norepinephrine; p-Chloroamphetamine; Quipazine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Ritanserin; Serotonin Receptor Agonists; Spiperone; Sulpiride

1992
5-Hydroxytryptamine increases excitability of CA1 hippocampal pyramidal cells.
    Synapse (New York, N.Y.), 1992, Volume: 10, Issue:4

    Topics: Action Potentials; Amphetamines; Animals; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neurons; Pyramidal Tracts; Rats; Rats, Inbred Strains; Serotonin; Spiperone; Synapses

1992
Effects of antipsychotic drugs on 5-HT2 receptors in the medial prefrontal cortex: microiontophoretic studies.
    Brain research, 1990, Jan-08, Volume: 506, Issue:2

    Topics: Amphetamines; Animals; Antipsychotic Agents; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Evoked Potentials; Frontal Lobe; Haloperidol; Iontophoresis; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone

1990
Do functional relationships exist between 5-HT1A and 5-HT2 receptors?
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Ketanserin; Male; Methoxydimethyltryptamines; Mice; Mice, Inbred ICR; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Stereoisomerism; Tetrahydronaphthalenes

1990
Systemic and regional haemodynamic effects of 1-(2,5-dimethoxy-4-iodo-phenyl)-2-aminopropane (DOI) and alpha-methyl-5-HT, in the anaesthetised rat.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 1994, Volume: 16, Issue:6

    Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Ergolines; Hemodynamics; Injections, Intravenous; Injections, Intraventricular; Male; Rats; Rats, Wistar; Regional Blood Flow; Renal Circulation; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Splanchnic Circulation

1994
A slow excitatory postsynaptic potential mediated by 5-HT2 receptors in nucleus prepositus hypoglossi.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:4

    Topics: Amphetamines; Animals; Brain Stem; Cyclohexane Monoterpenes; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Ketanserin; Male; Medulla Oblongata; Membrane Potentials; Neurons; Pindolol; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Sumatriptan; Synaptic Transmission

1994
Serotonin-mediated 5-HT2 receptor gene regulation in rat myometrial smooth muscle cells.
    Molecular and cellular endocrinology, 1993, Volume: 92, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Biguanides; Cells, Cultured; Cycloheximide; Female; Gene Expression Regulation; Ketanserin; Medroxyprogesterone Acetate; Myometrium; Piperazines; Quipazine; Rats; Receptors, Serotonin; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Sulpiride; Transcription, Genetic; Up-Regulation

1993
Serotonin-dependent collagenase induction in rat myometrial smooth muscle cells: mediation by the 5-HT2 receptor.
    Molecular and cellular endocrinology, 1993, Volume: 91, Issue:1-2

    Topics: Amphetamines; Animals; Base Sequence; Blotting, Northern; Collagenases; Female; Iodine Radioisotopes; Ketanserin; Molecular Sequence Data; Myometrium; Polymerase Chain Reaction; Rats; Receptors, Serotonin; RNA, Messenger; Serotonin; Serotonin Receptor Agonists; Spiperone

1993
Serotonin2/1C receptor activation causes a localized expression of the immediate-early gene c-fos in rat brain: evidence for involvement of dorsal raphe nucleus projection fibres.
    Neuroscience, 1993, Volume: 53, Issue:2

    Topics: Amphetamines; Animals; Behavior, Animal; Brain Chemistry; Deoxyglucose; Gene Expression; Genes, fos; Immunohistochemistry; Male; Nerve Fibers; Neural Pathways; Proto-Oncogene Proteins c-fos; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Ritanserin; Serotonin Receptor Agonists; Spiperone

1993
Dexamethasone potentiates serotonin-2 receptor-mediated intracellular Ca2+ mobilization in C6 glioma cells.
    Neuroendocrinology, 1993, Volume: 57, Issue:2

    Topics: Amphetamines; Animals; Calcium; Dexamethasone; Glioma; Ketanserin; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Tumor Cells, Cultured

1993
Stimulation of 5-HT2A receptors in the paraventricular hypothalamus attenuates neuropeptide Y-induced hyperphagia through activation of corticotropin releasing factor.
    Brain research, 1996, Feb-05, Volume: 708, Issue:1-2

    Topics: Amphetamines; Animals; Corticotropin-Releasing Hormone; Feeding Behavior; Hyperphagia; Indoles; Male; Neuropeptide Y; Paraventricular Hypothalamic Nucleus; Piperazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Receptor Agonists; Spiperone

1996
Agonist and antagonist binding to rabbit cortical 5-HT2A receptors: opposite effects of magnesium.
    Annals of the New York Academy of Sciences, 1998, Dec-15, Volume: 861

    Topics: Amphetamines; Animals; Cerebral Cortex; Fluorobenzenes; Guanylyl Imidodiphosphate; Ketanserin; Magnesium; Methysergide; Piperidines; Prazosin; Rabbits; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone

1998
High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.
    Journal of neurochemistry, 1999, Volume: 72, Issue:5

    Topics: Amphetamines; Binding, Competitive; Cell Line; Ergolines; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrolysis; Isomerism; Ligands; Models, Biological; Phosphatidylinositols; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone

1999
Evidence for a role for central 5-HT2B as well as 5-HT2A receptors in cardiovascular regulation in anaesthetized rats.
    British journal of pharmacology, 1999, Volume: 128, Issue:3

    Topics: Amidines; Amphetamines; Animals; Antidiuretic Hormone Receptor Antagonists; Atropine Derivatives; Blood Pressure; Cardiovascular Physiological Phenomena; Cinanserin; Injections, Intraventricular; Male; Polyethylene Glycols; Quipazine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptors, Serotonin; Serotonin Antagonists; Spiperone

1999
5-HT(2A/2C) receptor antagonists in the paraventricular nucleus attenuate the action of DOI on NPY-stimulated eating.
    Neuroreport, 1999, Sep-29, Volume: 10, Issue:14

    Topics: Amphetamines; Animals; Appetite Stimulants; Eating; Male; Mianserin; Neuropeptide Y; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Ventromedial Hypothalamic Nucleus

1999