sphingosyl-beta-glucoside has been researched along with benzoxazolone* in 1 studies
1 other study(ies) available for sphingosyl-beta-glucoside and benzoxazolone
Article | Year |
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Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors.
Sphingolipids (SphLs) are a diverse class of molecules that are regulated by a complex network of enzymatic pathways. A disturbance in these pathways leads to lipid accumulation and initiation of several SphL-related disorders. Acid ceramidase is one of the key enzymes that regulate the metabolism of ceramides and glycosphingolipids, which are important members of the SphL family. Herein, we describe the lead optimization studies of benzoxazolone carboxamides resulting in piperidine Topics: Acid Ceramidase; Administration, Oral; Animals; Benzoxazoles; Brain; Cell Line, Tumor; Enzyme Inhibitors; Female; Gaucher Disease; Humans; Leukodystrophy, Globoid Cell; Male; Mice; Molecular Structure; Psychosine; Structure-Activity Relationship | 2020 |