sphingosyl-beta-glucoside and benzoxazolone

Sphingolipids (SphLs) are a diverse class of molecules that are regulated by a complex network of enzymatic pathways. A disturbance in these pathways leads to lipid accumulation and initiation of several SphL-related disorders. Acid ceramidase is one of the key enzymes that regulate the metabolism of ceramides and glycosphingolipids, which are important members of the SphL family. Herein, we describe the lead optimization studies of benzoxazolone carboxamides resulting in piperidine

Topics: Acid Ceramidase; Administration, Oral; Animals; Benzoxazoles; Brain; Cell Line, Tumor; Enzyme Inhibitors; Female; Gaucher Disease; Humans; Leukodystrophy, Globoid Cell; Male; Mice; Molecular Structure; Psychosine; Structure-Activity Relationship