sphingosine-phosphorylcholine and cholesteryl-sulfate

sphingosine-phosphorylcholine has been researched along with cholesteryl-sulfate* in 1 studies

Other Studies

1 other study(ies) available for sphingosine-phosphorylcholine and cholesteryl-sulfate

ArticleYear
Serine base exchange enzyme activity is modulated by sphingosine and other amphiphilic compounds: possible role of positive charge in increasing the synthesis of phosphatidylserine.
    Biochemical and biophysical research communications, 1997, Dec-08, Volume: 241, Issue:1

    It has been found that sphingosine and sphingosylphosphorylcholine (amphiphilic cations) have a stimulatory, and cholesterol 3-sulfate (an amphiphilic anion), an inhibitory, effect on [14C]serine incorporation into phosphatidylserine in glioma C6 and rat liver microsomes. In glioma intact cells sphingosine stimulates phosphatidylserine synthesis in a process independent of protein kinase C, but suppressed by thapsigargin. We suggest that the stimulation of the enzyme occurs by the interaction of amphiphilic cations with the membrane cosubstrate phospholipids, leading to a charge redistribution on their phosphate groups, and hence facilitating the enzyme action. A new hypothesis concerning the mechanism of the serine base exchange reaction is discussed.

    Topics: Animals; Cholesterol Esters; Glioma; Kinetics; Microsomes; Microsomes, Liver; Nitrogenous Group Transferases; Phosphatidylserines; Phosphorylcholine; Protein Kinase C; Rats; Sphingosine; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured

1997