sphingosine-kinase has been researched along with nephrin* in 1 studies
1 other study(ies) available for sphingosine-kinase and nephrin
| Article | Year |
|---|---|
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
The sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that is now appreciated as key regulatory factor for various cellular functions in the kidney, including matrix remodeling. It is generated by two sphingosine kinases (Sphk), Sphk1 and Sphk2, which are ubiquitously expressed, but have distinct enzymatic activities and subcellular localizations. In this study, we have investigated the role of Sphk2 in podocyte function and its contribution to diabetic nephropathy. We show that streptozotocin (STZ)-induced nephropathy and albuminuria in mice is prevented by genetic depletion of Sphk2. This protection correlated with an increased protein expression of the transcription factor Wilm's tumor suppressor gene 1 (WT1) and its target gene nephrin, and a reduced macrophage infiltration in immunohistochemical renal sections of STZ-treated Sphk2 Topics: Albuminuria; Animals; Diabetic Nephropathies; Genes, Tumor Suppressor; Membrane Proteins; Mice; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Podocytes; Streptozocin; WT1 Proteins | 2021 |