sphingosine-kinase and 4-cyanobenzaldehyde

sphingosine-kinase has been researched along with 4-cyanobenzaldehyde* in 1 studies

Other Studies

1 other study(ies) available for sphingosine-kinase and 4-cyanobenzaldehyde

Article	Year
Discovery of novel sphingosine kinase-1 inhibitors. Part 2. Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15 Building on our initial work, we have identified additional novel inhibitors of sphingosine kinase-1 (SK1). These new analogs address the shortcomings found in our previously reported compounds. Inhibitors 51 and 54 demonstrated oral bioavailability in a rat PK study. Topics: Animals; Benzaldehydes; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Lithium; Microsomes, Liver; Phosphotransferases (Alcohol Group Acceptor); Rats	2010

Article

Year

Discovery of novel sphingosine kinase-1 inhibitors. Part 2.

Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15

Building on our initial work, we have identified additional novel inhibitors of sphingosine kinase-1 (SK1). These new analogs address the shortcomings found in our previously reported compounds. Inhibitors 51 and 54 demonstrated oral bioavailability in a rat PK study.

Topics: Animals; Benzaldehydes; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Lithium; Microsomes, Liver; Phosphotransferases (Alcohol Group Acceptor); Rats

2010