spermine and n-methylaspartate

spermine has been researched along with n-methylaspartate in 54 studies

Research

Studies (54)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.85)18.7374
1990's39 (72.22)18.2507
2000's11 (20.37)29.6817
2010's2 (3.70)24.3611
2020's1 (1.85)2.80

Authors

AuthorsStudies
Macdonald, RL; Rock, DM3
Benavides, J; Bourdiol, F; Carter, C; Fage, D; Porcella, A; Scatton, B; Voltz, C1
Brackley, P; Goodnow, R; Nakanishi, K; Sudan, HL; Usherwood, PN1
Bennett, MV; McGurk, JF; Zukin, RS1
Bednar, DL; Karbon, EW; Maciver, CR1
Carter, CJ; Lloyd, KG; Scatton, B; Zivkovic, B1
Dudek, S; Joly, M; Lynch, G; Muller, D; Schottler, F; Thibault, O1
Boxer, PA; Robichaud, LJ1
Chen, HS; Escobar, W; Heinemann, SF; Lipton, SA; Sullivan, JM; Traynelis, SF1
el-Fakahany, EE; Hu, J; Mahmoud, MI1
Horimoto, N; Kawamoto, I; Nabekura, J; Ogawa, T1
Ascher, P; Neyton, J; Paoletti, P1
Bowe, MA; Nadler, JV1
Fahey, JM; Lindquist, DG; Miller, LG; Pritchard, GA1
Arima, T; Kitamura, Y; Nakamura, J; Nomura, Y; Sato, T1
Fahey, JM; Miller, LG1
Iqbal, Z; Siddiqui, F1
Chen, DZ; Chen, SH; Katsura, M; Kuriyama, K; Ohkuma, S1
Carter, C; Fage, D; Voltz, C2
Abe, K; Chu, PJ; Saito, H; Samejima, K; Shirahata, A1
Williams, K1
Kamiya, H; Sawada, S; Yamamoto, C1
Conaty, C; Fahey, JM; Miller, LG; Minocha, SC; Pritchard, GA1
Bennett, MV; Durand, GM; Zhang, L; Zheng, X; Zukin, RS1
Benveniste, M; Mayer, ML1
Chandler, P; Maccecchini, ML; Nashed, NT; Pennington, M; Skolnick, P1
McGonigle, P; Munir, M; Subramaniam, S1
Araneda, RC; Bennett, MV; Zukin, RS1
Donevan, SD; Rogawski, MA; Subramaniam, S1
Johnson, SW; Wu, YN1
Bonnafous, C; Colombo, S; Lanza, M; Makovec, F; Revel, L1
Lovinger, DM; Peoples, RW; Weight, FF; White, G1
Fabiano, C; Ientile, R; Macaione, S; Macaione, V; Pedale, S; Picciurro, V1
Kemp, JA; Kew, JN1
Lu, WY; MacDonald, JF; Orser, BA; Xiong, ZG1
Castellino, FJ; Galdzicki, Z; Klein, RC1
Bertrand, S; Cazalets, JR1
Anderson, CM; Chan, PH; Chen, Y; Copin, JC; Fahlman, CS; Stein, BA; Swanson, RA; Ying, W1
Biello, M; Ferchmin, PA; Pérez, D1
Lovinger, DM; Popp, RL1
Calderón, F; López, E; López-Colomé, AM; Rodríguez, G1
Bunney, BS; Shi, WX; Zhang, XX1
Caruso, A; Castellino, FJ; Galdzicki, Z; Klein, RC; Rapoport, SI; Siarey, RJ1
Hu, GY; Zhang, JM1
Kirby, BP; Renault, J; Ryder, SA; Seiler, N; Shaw, GG1
Hoskison, MM; Obata, K; Shuttleworth, CW; Yanagawa, Y1
Brown, BE; Castellino, FJ; Prorok, M; Sheng, Z1
Igarashi, K; Kashiwagi, K; Kizawa, Y; Kusama, T; Masuko, T; Miyake, M; Namiki, R; Nemoto, Y; Suzuki, T1
Armand, V; Arrang, JM; Bayard, C; Burban, A; Faucard, R; Vorobjev, V1
Chen, Y; Guo, LP; Hu, XL; Meng, WH; Song, Q; Wang, J; Zhang, Q; Zhao, QC1
Gao, L; Jiang, X; Li, X; Liu, W; Liu, Y; Niu, Y; Yang, Y; Zhao, Q1

Other Studies

54 other study(ies) available for spermine and n-methylaspartate

ArticleYear
The polyamine diaminodecane (DA-10) produces a voltage-dependent flickery block of single NMDA receptor channels.
    Neuroscience letters, 1992, Sep-14, Volume: 144, Issue:1-2

    Topics: Animals; Diamines; Female; Ion Channels; Kinetics; N-Methylaspartate; Neurons; Oocytes; Polyamines; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Spermine

1992
Implication of the polyamines in the neurotoxic effects of N-methyl-D-aspartate.
    Neurological research, 1992, Volume: 14, Issue:2 Suppl

    Topics: Animals; Cell Membrane; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Glutamate Decarboxylase; Infusions, Parenteral; Isoquinolines; Microinjections; N-Methylaspartate; Neurotoxins; Rats; Receptors, GABA-A; Spermidine; Spermine; Tetrodotoxin

1992
The polyamine spermine has multiple actions on N-methyl-D-aspartate receptor single-channel currents in cultured cortical neurons.
    Molecular pharmacology, 1992, Volume: 41, Issue:1

    Topics: Animals; Cells, Cultured; Cerebral Cortex; Ion Channels; Kinetics; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Spermine

1992
Spermine and related polyamines produce a voltage-dependent reduction of N-methyl-D-aspartate receptor single-channel conductance.
    Molecular pharmacology, 1992, Volume: 42, Issue:1

    Topics: Animals; Biguanides; Cells, Cultured; Cerebral Cortex; Hydrogen-Ion Concentration; Ion Channel Gating; Ion Channels; Membrane Potentials; N-Methylaspartate; Neurons; Polyamines; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate; Spermine

1992
Spermine and philanthotoxin potentiate excitatory amino acid responses of Xenopus oocytes injected with rat and chick brain RNA.
    Neuroscience letters, 1990, Jun-22, Volume: 114, Issue:1

    Topics: Amino Acids; Animals; Aspartic Acid; Bee Venoms; Brain; Chickens; Kainic Acid; Male; Membrane Potentials; Microinjections; N-Methylaspartate; Neurotoxins; Oocytes; Oxadiazoles; Poly A; Polyamines; Quisqualic Acid; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Spermine; Wasp Venoms; Xenopus

1990
Polyamines potentiate responses of N-methyl-D-aspartate receptors expressed in xenopus oocytes.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:24

    Topics: Animals; Brain; Female; Glycine; Kinetics; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Poly A; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; RNA; RNA, Messenger; Spermine; Xenopus laevis

1990
Opposite effects of spermine and arcaine on responses of N-methyl-D-aspartate receptors expressed in Xenopus oocytes.
    Neuroscience letters, 1991, Nov-11, Volume: 132, Issue:2

    Topics: Animals; Biguanides; Glycine; N-Methylaspartate; Oocytes; Polyamines; Receptors, N-Methyl-D-Aspartate; Spermine; Xenopus

1991
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Drug Interactions; Female; Glycine; Male; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Spinal Cord

1990
Long-lasting physiological effects of bath applied N-methyl-D-aspartate.
    Brain research, 1989, Jan-02, Volume: 476, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Electric Stimulation; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Spermine; Time Factors; Valine

1989
Polyamine modulation of excitatory amino acid responses in the rat cortical wedge.
    Neuropharmacology, 1993, Volume: 32, Issue:10

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Biogenic Polyamines; Cerebral Cortex; Epilepsy; In Vitro Techniques; Male; Membrane Potentials; Models, Biological; N-Methylaspartate; Rats; Rats, Wistar; Spermine

1993
Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor.
    Neuron, 1994, Volume: 13, Issue:4

    Topics: Animals; Cysteine; Dithiothreitol; Electrophysiology; Female; Ion Channel Gating; Ion Channels; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylaspartate; Oocytes; Oxidation-Reduction; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Structure-Activity Relationship; Xenopus

1994
Polyamines inhibit nitric oxide synthase in rat cerebellum.
    Neuroscience letters, 1994, Jul-04, Volume: 175, Issue:1-2

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cells, Cultured; Cerebellum; Citrulline; Cytosol; Eflornithine; Kinetics; N-Methylaspartate; Neurons; Nitric Oxide Synthase; omega-N-Methylarginine; Polyamines; Putrescine; Rats; Spermidine; Spermine; Tritium

1994
Developmental change of the potentiation of NMDA response by spermine.
    Neuroreport, 1995, May-09, Volume: 6, Issue:7

    Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Drug Synergism; Electrophysiology; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Nystatin; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Spermine; Ventromedial Hypothalamic Nucleus

1995
Glycine-independent and subunit-specific potentiation of NMDA responses by extracellular Mg2+.
    Neuron, 1995, Volume: 15, Issue:5

    Topics: Animals; Barium; Calcium; Cell Line; Drug Synergism; Electric Conductivity; Embryo, Mammalian; Embryo, Nonmammalian; Female; Glycine; Humans; Hydrogen-Ion Concentration; Kidney; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Xenopus

1995
Polyamines antagonize N-methyl-D-aspartate-evoked depolarizations, but reduce Mg2+ block.
    European journal of pharmacology, 1995, May-04, Volume: 278, Issue:1

    Topics: Action Potentials; Analysis of Variance; Animals; Binding, Competitive; Chromatography, High Pressure Liquid; Diamines; Drug Interactions; Eflornithine; Female; Hippocampus; Magnesium; Male; N-Methylaspartate; Phencyclidine; Polyamines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Spermine

1995
Pregnenolone sulfate potentiation of NMDA-mediated increases in intracellular calcium in cultured chick cortical neurons.
    Brain research, 1995, Jan-16, Volume: 669, Issue:2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Fura-2; Glycine; N-Methylaspartate; Nimodipine; Pregnenolone; Spermine

1995
Inhibitory effects of pentamidine on N-methyl-D-aspartate (NMDA) receptor/channels in the rat brain.
    Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:2

    Topics: Animals; Antiviral Agents; Brain; Calcium Channels; Dizocilpine Maleate; Glycine; Mice; N-Methylaspartate; Nitrendipine; Nitric Oxide; Pentamidine; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spermine; Xenopus

1995
Interleukin-1 modulates GABAergic and glutamatergic function in brain.
    Annals of the New York Academy of Sciences, 1994, Oct-31, Volume: 739

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain; Calcium; Cells, Cultured; Chick Embryo; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Interleukin-1; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Recombinant Proteins; Spermine; Tumor Necrosis Factor-alpha

1994
Regulation of N-methyl-D-aspartate receptor-mediated calcium transport and norepinephrine release in rat hippocampus synaptosomes by polyamines.
    Neurochemical research, 1994, Volume: 19, Issue:11

    Topics: 2-Amino-5-phosphonovalerate; Animals; Biological Transport; Calcium; Eflornithine; Egtazic Acid; Female; Hippocampus; Kinetics; N-Methylaspartate; Norepinephrine; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Synaptosomes

1994
Presence of N-methyl-D-aspartate (NMDA) receptors in neuroblastoma x glioma hybrid NG108-15 cells-analysis using [45Ca2+]influx and [3H]MK-801 binding as functional measures.
    Brain research. Molecular brain research, 1994, Volume: 22, Issue:1-4

    Topics: Calcium Radioisotopes; Cations, Divalent; Dizocilpine Maleate; Glioma; Glutamates; Glutamic Acid; Glycine; Hybrid Cells; N-Methylaspartate; Neuroblastoma; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Spermine; Tritium

1994
Synergism between the NMDA receptor antagonistic effects of ifenprodil and the glycine antagonist, 7-chlorokynurenate, in vivo.
    European journal of pharmacology, 1994, Apr-01, Volume: 255, Issue:1-3

    Topics: Animals; Chromatography, High Pressure Liquid; Drug Synergism; Glycine; Injections; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine

1994
N-(3-aminopropyl)-cyclohexylamine blocks facilitation by spermidine of N-methyl-DL-aspartate-induced seizure in mice in vivo.
    European journal of pharmacology, 1994, Apr-21, Volume: 256, Issue:2

    Topics: Animals; Cyclohexylamines; Drug Interactions; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Putrescine; Seizures; Serine; Spermidine; Spermine

1994
Mechanisms influencing stimulatory effects of spermine at recombinant N-methyl-D-aspartate receptors.
    Molecular pharmacology, 1994, Volume: 46, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; N-Methylaspartate; Peptide Fragments; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Xenopus laevis

1994
Long-lasting potentiation of synaptic transmission in the Schaffer collateral-commissural pathway of the guinea pig hippocampus by activation of postsynaptic N-methyl-D-aspartate receptor.
    Synapse (New York, N.Y.), 1993, Volume: 13, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Evoked Potentials; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Spermine; Synapses; Synaptic Transmission

1993
Polyamine potentiation and inhibition of NMDA-mediated increases of intracellular free Ca2+ in cultured chick cortical neurons.
    European journal of pharmacology, 1994, Jan-15, Volume: 266, Issue:2

    Topics: Animals; Biogenic Polyamines; Calcium; Cells, Cultured; Cerebral Cortex; Chick Embryo; Chromatography, High Pressure Liquid; Fura-2; Ion Transport; N-Methylaspartate; Neurons; Polyamines; Putrescine; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine

1994
Mutagenesis rescues spermine and Zn2+ potentiation of recombinant NMDA receptors.
    Neuron, 1994, Volume: 12, Issue:4

    Topics: Amino Acid Sequence; Animals; Base Sequence; Drug Synergism; Electrophysiology; Female; Glycine; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Transfection; Xenopus; Zinc

1994
Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of rat cultured hippocampal neurones.
    The Journal of physiology, 1993, Volume: 464

    Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Hippocampus; Kinetics; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Spermine

1993
Polyamine-like actions of peptides derived from conantokin-G, an N-methyl-D-aspartate (NMDA) antagonist.
    The Journal of biological chemistry, 1993, Aug-15, Volume: 268, Issue:23

    Topics: Amino Acid Sequence; Animals; Biguanides; Circular Dichroism; Conotoxins; Magnesium; Male; Molecular Sequence Data; N-Methylaspartate; Peptides, Cyclic; Polyamines; Rats; Rats, Sprague-Dawley; Spermine

1993
Polyamines modulate the neurotoxic effects of NMDA in vivo.
    Brain research, 1993, Jul-09, Volume: 616, Issue:1-2

    Topics: Animals; Brain; Corpus Striatum; Diamines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Male; N-Methylaspartate; Neurotoxins; Polyamines; Rats; Rats, Sprague-Dawley; Spermine

1993
Ouabain releases striatal polyamines in vivo independently of N-methyl-D-aspartate receptor activation.
    Journal of neurochemistry, 1993, Volume: 61, Issue:1

    Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Male; N-Methylaspartate; Ouabain; Piperazines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine

1993
Effects of polyamines on NMDA-induced currents in rat hippocampal neurons: a whole-cell and single-channel study.
    Neuroscience letters, 1993, Apr-02, Volume: 152, Issue:1-2

    Topics: Action Potentials; Animals; Cells, Cultured; Drug Synergism; Hippocampus; Ion Channel Gating; N-Methylaspartate; Neurons; Rats; Spermidine; Spermine

1993
Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:1

    Topics: Acetamides; Animals; Anticonvulsants; Binding Sites; Cells, Cultured; Dizocilpine Maleate; Hippocampus; Kinetics; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Phenethylamines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Spermine; Tritium

1996
Pharmacological characterization of inward current evoked by N-methyl-D-aspartate in dopamine neurons in the rat brain slice.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:2

    Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Sodium; Spermine; Substantia Nigra; Ventral Tegmental Area

1996
Characterization of a novel putative cognition enhancer mediating facilitation of glycine effect on strychnine-resistant sites coupled to NMDA receptor complex.
    Neuropharmacology, 1997, Volume: 36, Issue:8

    Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nootropic Agents; Norepinephrine; Pentanoic Acids; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Spermine; Stereoisomerism

1997
Ethanol inhibition of N-methyl-D-aspartate-activated current in mouse hippocampal neurones: whole-cell patch-clamp analysis.
    British journal of pharmacology, 1997, Volume: 122, Issue:6

    Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Ethanol; Hippocampus; Hydrogen-Ion Concentration; Ketamine; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Oxidation-Reduction; Patch-Clamp Techniques; Spermine; Zinc

1997
Nitric oxide mediates NMDA-evoked [3H]GABA release from chick retina cells.
    FEBS letters, 1997, Nov-17, Volume: 417, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Cells, Cultured; Chick Embryo; Cyclic GMP; Dizocilpine Maleate; gamma-Aminobutyric Acid; Isoquinolines; N-Methylaspartate; Nitric Oxide; Nitroarginine; Nitrogen Oxides; Purinones; Receptors, N-Methyl-D-Aspartate; Retina; Spermine; Tritium

1997
An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones.
    The Journal of physiology, 1998, Oct-01, Volume: 512 ( Pt 1)

    Topics: Allosteric Regulation; Allosteric Site; Animals; Benzamides; Binding Sites; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Evoked Potentials; Excitatory Amino Acid Antagonists; Magnesium; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Spermine

1998
Multiple sites of action of neomycin, Mg2+ and spermine on the NMDA receptors of rat hippocampal CA1 pyramidal neurones.
    The Journal of physiology, 1998, Oct-01, Volume: 512 ( Pt 1)

    Topics: Animals; Binding Sites; Calcium; Cell Line; Cells, Cultured; Evoked Potentials; Glutamic Acid; Glycine; Hippocampus; Humans; Magnesium; N-Methylaspartate; Neomycin; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate; Spermine; Transfection

1998
Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons.
    Neuropharmacology, 1999, Volume: 38, Issue:12

    Topics: Animals; Cells, Cultured; Conotoxins; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mollusk Venoms; N-Methylaspartate; Neurons; Peptides; Receptors, N-Methyl-D-Aspartate; Spermine

1999
Regulation by glycine, Mg2+ and polyamines of the N-methyl-D-aspartate-induced locomotion in the neonatal rat spinal cord in vitro.
    Neuroscience, 1999, Volume: 94, Issue:4

    Topics: Animals; Biguanides; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Kynurenic Acid; Magnesium; Motor Activity; Motor Neurons; N-Methylaspartate; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Spinal Cord; Synapses

1999
Differing effects of copper,zinc superoxide dismutase overexpression on neurotoxicity elicited by nitric oxide, reactive oxygen species, and excitotoxins.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:2

    Topics: Animals; Astrocytes; Cell Death; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; Glutamic Acid; Humans; Hydrazines; Kainic Acid; Mice; Mice, Transgenic; N-Methylaspartate; Neurons; Neurotoxins; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Penicillamine; Reactive Oxygen Species; Spermine; Superoxide Dismutase; Tyrosine; Vitamin K

2000
Spermine is neuroprotective against anoxia and N-methyl-D-aspartate in hippocampal slices.
    Brain research, 2000, Mar-24, Volume: 859, Issue:2

    Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Hippocampus; Hypoxia, Brain; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine

2000
Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons.
    European journal of pharmacology, 2000, Apr-14, Volume: 394, Issue:2-3

    Topics: Acamprosate; Alcohol Deterrents; Animals; Cells, Cultured; Central Nervous System Depressants; Electrophysiology; Ethanol; Excitatory Amino Acid Agonists; In Vitro Techniques; N-Methylaspartate; Neostriatum; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Taurine; Transfection

2000
Calcium-independent release of [3H]spermine from chick retina.
    Brain research, 2000, Jan-31, Volume: 854, Issue:1-2

    Topics: Animals; Animals, Newborn; Calcium; Chickens; Digitoxigenin; Enzyme Inhibitors; Excitatory Amino Acid Agonists; In Vitro Techniques; N-Methylaspartate; Ouabain; Potassium Chloride; Retina; Sodium; Sodium-Potassium-Exchanging ATPase; Spermine; Tritium

2000
Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil.
    Synapse (New York, N.Y.), 2000, Volume: 37, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine

2000
Increased expression of NR2A subunit does not alter NMDA-evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons.
    Journal of neurochemistry, 2001, Volume: 76, Issue:6

    Topics: Animals; Chromosome Mapping; Diploidy; Disease Models, Animal; Down Syndrome; Evoked Potentials; Female; Heterozygote; Hippocampus; Humans; Male; Membrane Potentials; Mice; Mice, Mutant Strains; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Spermine; Trisomy; Zinc

2001
Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.
    Neuroscience, 2001, Volume: 105, Issue:3

    Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Cells, Cultured; Dithiothreitol; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Hydrogen-Ion Concentration; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neuroprotective Agents; Nootropic Agents; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes; Spermine; Zinc

2001
N1-dansyl-spermine: a potent polyamine antagonist.
    Brain research, 2004, Jun-11, Volume: 1011, Issue:1

    Topics: Animals; Central Nervous System; Dansyl Compounds; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Female; Injections, Intraventricular; Mice; N-Methylaspartate; Polyamines; Reaction Time; Seizures; Spermine

2004
Calcium-dependent NMDA-induced dendritic injury and MAP2 loss in acute hippocampal slices.
    Neuroscience, 2007, Mar-02, Volume: 145, Issue:1

    Topics: Animals; Calcium; Dendrites; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Mice; Microtubule-Associated Proteins; N-Methylaspartate; Spermine; Time Factors

2007
N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein.
    Neuropharmacology, 2008, Volume: 55, Issue:2

    Topics: Animals; Apolipoproteins E; Binding Sites; Cell Line, Transformed; Cell Membrane; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Glycine; Humans; LDL-Receptor Related Proteins; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Peptide Fragments; Protein Binding; Receptors, N-Methyl-D-Aspartate; Spermine; Transfection

2008
Neuroprotection by tosyl-polyamine derivatives through the inhibition of ionotropic glutamate receptors.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 331, Issue:2

    Topics: Animals; Anthraquinones; Cell Line, Tumor; Cells, Cultured; Cloning, Molecular; Dansyl Compounds; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; Humans; Mice; N-Methylaspartate; Neuroblastoma; Neurons; Neuroprotective Agents; Oocytes; Patch-Clamp Techniques; Polyamines; Pregnancy; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Seizures; Spermine; Tosyl Compounds; Xenopus laevis

2009
Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding site.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Allosteric Site; Animals; Binding Sites; Calcium; Dizocilpine Maleate; Drug Synergism; Hippocampus; Histamine; In Vitro Techniques; Intracellular Space; Male; Methylhistamines; N-Methylaspartate; Neurons; Norepinephrine; Piperidines; Polyamines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Synaptosomes

2010
Kukoamine B, an amide alkaloid, protects against NMDA-induced neurotoxicity and potential mechanisms in vitro.
    Neurochemistry international, 2015, Volume: 87

    Topics: Acetophenones; Apoptosis; bcl-2-Associated X Protein; Caffeic Acids; Calcium; Cell Line, Tumor; Dizocilpine Maleate; Humans; In Vitro Techniques; Ion Transport; L-Lactate Dehydrogenase; Malondialdehyde; Matrix Metalloproteinases; N-Methylaspartate; Neurons; Reactive Oxygen Species; Spermine; Superoxide Dismutase

2015
Kukoamine A Protects against NMDA-Induced Neurotoxicity Accompanied with Down-Regulation of GluN2B-Containing NMDA Receptors and Phosphorylation of PI3K/Akt/GSK-3β Signaling Pathway in Cultured Primary Cortical Neurons.
    Neurochemical research, 2020, Volume: 45, Issue:11

    Topics: Animals; Apoptosis; Down-Regulation; Glycogen Synthase Kinase 3 beta; N-Methylaspartate; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spermine

2020