spermine has been researched along with fluorouracil in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gruber, JD; Pachaiyappan, B; Schmidt, MG; Wang, B; Woster, PM; Zhang, YM | 1 |
| Tormey, DC; Waalkes, TP | 1 |
| Endoh, F; Fujimoto, S; Igarashi, K; Kawata, S; Miyazaki, M; Ohta, M; Shimura, T; Shrestha, RD; Sugasawa, H; Takahashi, O | 1 |
| Hopkins, HA; Kovacs, CJ; LeGendre, SM; Looney, WB; Marton, LJ; Morris, HP; Russell, DH | 1 |
| Carew, J; Choi, W; Dupart, J; Gerner, EW; Hamilton, SR; Huang, P; Proctor, L; Ramdas, L; Zhang, W | 1 |
| Chiao, PJ; Choi, W; Feng, Y; Gerner, EW; Hamilton, SR; Proctor, L; Xia, Q; Zhang, W | 1 |
| Clark, K; Diegelman, P; Fakih, M; Hector, S; Kisiel, ND; Kramer, DL; Pendyala, L; Porter, CW; Tummala, R; Vujcic, S | 1 |
| Billam, M; Casero, RA; Davidson, NE; Hacker, A; Pledgie-Tracy, A; Sobolewski, MD; Woster, PM; Zhang, Z | 1 |
| Doki, Y; Ishii, H; Kano, Y; Kawamoto, K; Konno, M; Koseki, J; Matsui, H; Mori, M; Nishida, N | 1 |
| Becerra, CHR; Boyd, TE; Casero, RA; Conkling, PR; Fitzgerald, M; Garbo, LE; Jotte, RM; Marton, LJ; Murray Stewart, T; Richards, DA; Smith, DA; Stephenson, JJ; Vogelzang, NJ; Von Hoff, D; Wu, HH | 1 |
1 review(s) available for spermine and fluorouracil
| Article | Year |
|---|---|
Biochemical markers in cancer of the breast.
Topics: Breast Neoplasms; Cadaverine; Carcinoembryonic Antigen; Chorionic Gonadotropin; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Guanosine; Humans; Inosine; Methotrexate; Neoplasm Metastasis; Prognosis; Putrescine; Recurrence; Spermidine; Spermine | 1976 |
1 trial(s) available for spermine and fluorouracil
| Article | Year |
|---|---|
A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cisplatin; Deoxycytidine; Docetaxel; Dose-Response Relationship, Drug; Erlotinib Hydrochloride; Female; Fluorouracil; Gemcitabine; Humans; Lymphoma; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Spermine; Sunitinib | 2021 |
8 other study(ies) available for spermine and fluorouracil
| Article | Year |
|---|---|
Antibacterial Diamines Targeting Bacterial Membranes.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Caenorhabditis elegans; Cell Membrane; Cell Membrane Permeability; Chemistry Techniques, Synthetic; Diamines; Drug Evaluation, Preclinical; Drug Interactions; Escherichia coli; HEK293 Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Staphylococcus aureus | 2016 |
[Anticancer treatment with a combination of antimetabolites of polyamine and pyrimidine].
Topics: Animals; DNA Replication; Drug Therapy, Combination; Eflornithine; Floxuridine; Fluorouracil; Mice; Mice, Nude; Mitoguazone; Ornithine; Polyamines; Spermine; Stomach Neoplasms | 1985 |
Polyamine depletion of tumor tissue and subsequent elevation of spermidine in the sera of rats with 3924A hepatomas after 5-fluorouracil administration.
Topics: Animals; Carcinoma, Hepatocellular; Female; Fluorouracil; Liver; Liver Neoplasms; Neoplasms, Experimental; Polyamines; Putrescine; Rats; Spermidine; Spermine; Time Factors | 1974 |
Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells.
Topics: Acetyltransferases; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antioxidants; Apoptosis; Caspase 9; Caspases; Cytochromes c; Drug Synergism; Fluorouracil; Gene Deletion; HCT116 Cells; Humans; Hydrogen Peroxide; Mitochondria; Polyamines; Spermine; Transcription, Genetic; Tumor Suppressor Protein p53 | 2005 |
Inactivation of IkappaB contributes to transcriptional activation of spermidine/spermine N(1)-acetyltransferase.
Topics: Acetyltransferases; Antineoplastic Agents; Colonic Neoplasms; Cycloheximide; Dactinomycin; Fluorouracil; Humans; I-kappa B Proteins; Membrane Potentials; Mitochondria; Mitochondrial Membranes; NF-kappa B; NF-kappa B p50 Subunit; Promoter Regions, Genetic; Protein Biosynthesis; Protein Synthesis Inhibitors; Response Elements; Spermine; Transcription Factor RelA; Transcriptional Activation; Tumor Cells, Cultured | 2006 |
Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine.
Topics: Acetyltransferases; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Fluorouracil; Gene Expression; Humans; Organoplatinum Compounds; Oxaliplatin; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Rectal Neoplasms; Spermine | 2008 |
The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines.
Topics: Acetyltransferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Female; Fluorouracil; Gene Expression Regulation, Enzymologic; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Oxidoreductases Acting on CH-NH Group Donors; Paclitaxel; Polyamine Oxidase; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Spermine; Xenograft Model Antitumor Assays | 2010 |
A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells.
Topics: Acetyltransferases; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cisplatin; Computational Biology; Drug Resistance, Neoplasm; Esophagus; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Metabolic Networks and Pathways; Metabolome; Models, Statistical; Neoplastic Stem Cells; Ornithine; Proteins; Putrescine; Spermidine; Spermine; Spermine Synthase; Transcriptome | 2016 |