spermidine has been researched along with piperidines in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.78) | 18.7374 |
| 1990's | 20 (55.56) | 18.2507 |
| 2000's | 12 (33.33) | 29.6817 |
| 2010's | 3 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Britt, M; Paschetto, KA; Powel, RJ; Pullan, LM; Stumpo, RJ | 1 |
| Abe, K; Chida, N; Saito, H | 1 |
| Reynolds, IJ | 1 |
| Cler, JA; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Canton, H; Colpaert, F; Lehmann, J | 1 |
| Ransom, RW | 1 |
| Beart, PM; Jarrott, B; Mercer, LD | 1 |
| Carter, CJ; Lloyd, KG; Scatton, B; Zivkovic, B | 1 |
| Bowen, DM; Cross, AJ; Francis, PT; Green, AR; Steele, JE | 1 |
| Carter, C; Rivy, JP; Scatton, B | 1 |
| Doyle, KM; Shaw, GG | 1 |
| Carter, C; Fage, D; Nankai, M | 1 |
| Anegawa, NJ; Dichter, M; Lawrence, JJ; Lenz, S; Lynch, DR; Pritchett, DB | 1 |
| Carter, C; Fage, D; Nicolas, C | 1 |
| Carter, C; Nicolas, C | 1 |
| Carter, C; Fage, D; Voltz, C | 1 |
| Akaike, A; Sasa, M; Sato, Y; Takaori, S; Tamura, Y; Yokota, T | 1 |
| Abe, K; Chida, N; Nishiyama, N; Saito, H | 1 |
| Gallagher, MJ; Huang, H; Lynch, DR; Pritchett, DB | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Gandolfi, O; Sparapani, M | 1 |
| Gallagher, MJ; Huang, H; Lynch, DR | 1 |
| Akaike, A; Honda, Y; Kaneda, K; Kashii, S; Kikuchi, M; Sato, S; Yasuyoshi, H; Zhang, S | 1 |
| Gallagher, MJ; Guttmann, RP; Kurapathi, S; Lynch, DR; Mutel, V; Seifert, KM; Shim, SS | 1 |
| Bobkiewicz-Kozlowska, T; Mikolajczak, P; Okulicz-Kozaryn, I; Polanska, A; Szczawinska, K | 1 |
| Cebere, A; Cebers, G; Liljequist, S; Wägner, A | 1 |
| Gebka, J; Kaminska, E; Mikolajczak, P; Niedopad, L; Okulicz-Kozaryn, I; Polanska, A | 1 |
| Gibson, DA; Harris, BR; Littleton, JM; Rogers, DT | 1 |
| Honse, Y; Leslie, SW; Randall, PK | 1 |
| Hozumi, S; Kisara, K; Murata, A; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Yamadera, F | 1 |
| Dohm, JA; Gittis, AG; Hsu, MH; Huang, RC; Hwu, JR; Lattman, EE; Moudrianakis, EN | 1 |
| Kamei, C; Masuoka, T; Saito, S | 1 |
| Barron, S; Littleton, JM; Mulholland, PJ; Prendergast, MA | 1 |
| Cramer, SM; Garde, S; Godawat, R; McCallum, SA; Morrison, CJ | 1 |
| Berry, JN; Butler, TR; Littleton, JM; Mulholland, PJ; Pauly, JR; Prendergast, MA; Self, RL; Sharrett-Field, LJ; Smith, KJ | 1 |
| Barron, S; Bochi, GV; da Rosa, MM; Ferreira, J; Gomes, GM; Mello, CF; Rubin, MA | 1 |
| Bär, J; Dalmolin, GD; Gomes, GM; Karpova, A; Kreutz, MR; Mello, CF; Rubin, MA | 1 |
36 other study(ies) available for spermidine and piperidines
| Article | Year |
|---|---|
Neomycin is an agonist at a polyamine site on the N-methyl-D-aspartate receptor.
Topics: Adrenergic alpha-Antagonists; Animals; Biguanides; Magnesium; Male; Neomycin; Phencyclidine; Piperazines; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes; Tritium | 1992 |
Spermine facilitates the generation of long-term potentiation of evoked potential in the dentate gyrus of anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Anesthesia, General; Animals; Cerebral Ventricles; Electric Stimulation; Evoked Potentials; Hippocampus; Injections, Intraventricular; Male; Piperidines; Putrescine; Rats; Rats, Wistar; Spermidine; Spermine; Time Factors | 1992 |
1,5-(Diethylamino)piperidine, a novel spermidine analogue that more specifically activates the N-methyl-D-aspartate receptor-associated polyamine site.
Topics: Allosteric Regulation; Animals; Binding Sites; Dizocilpine Maleate; Kinetics; Magnesium; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 1992 |
Polyamines modulate events mediated by the N-methyl-D-aspartate (NMDA) receptor complex through an ifenprodil-insensitive pathway: in vivo measurements of cyclic GMP in the cerebellum.
Topics: Animals; Biogenic Polyamines; Cerebellum; Cyclic GMP; Dizocilpine Maleate; Injections, Intraventricular; Male; Methamphetamine; Mice; Neural Pathways; Ornithine; Pentylenetetrazole; Piperidines; Putrescine; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Biguanides; Binding, Competitive; Biogenic Polyamines; Biotransformation; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
Polyamine and ifenprodil interactions with the NMDA receptor's glycine site.
Topics: Animals; Binding Sites; Drug Interactions; Glutamates; Glutamic Acid; Glycine; Male; Piperidines; Polyamines; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Statistics as Topic | 1991 |
[125I]Ifenprodil: a convenient radioligand for binding and autoradiographic studies of the polyamine-sensitive site of the NMDA receptor.
Topics: Animals; Autoradiography; Biogenic Polyamines; Calcium; Cerebral Cortex; Iodine Radioisotopes; Isotope Labeling; Magnesium; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Zinc | 1991 |
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Drug Interactions; Female; Glycine; Male; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Spinal Cord | 1990 |
Spermidine enhancement of [3H]MK-801 binding to the NMDA receptor complex in human cortical membranes.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Cerebral Cortex; Dizocilpine Maleate; Female; Humans; In Vitro Techniques; Kynurenic Acid; Male; Membranes; Piperidines; Radioligand Assay; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine | 1990 |
Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor.
Topics: Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Glutamates; Male; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine | 1989 |
The mechanism of the neurotoxic effects of spermidine.
Topics: Animals; Cerebral Ventricles; Dizocilpine Maleate; Guanidines; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurotoxins; Oxidoreductases Acting on CH-NH Group Donors; Piperidines; Putrescine; Receptors, N-Methyl-D-Aspartate; Spermidine; Stereotyped Behavior | 1994 |
NMDA receptor subtype selectivity: eliprodil, polyamine spider toxins, dextromethorphan, and desipramine selectively block NMDA-evoked striatal acetylcholine but not spermidine release.
Topics: Acetylcholine; Animals; Corpus Striatum; Desipramine; Dextromethorphan; Indoleacetic Acids; N-Methylaspartate; Phenols; Phenylacetates; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spider Venoms | 1995 |
Pharmacological characterization of heterodimeric NMDA receptors composed of NR 1a and 2B subunits: differences with receptors formed from NR 1a and 2A.
Topics: Animals; Brain; Cell Survival; Dizocilpine Maleate; Electrophysiology; Membranes; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Transfection | 1995 |
NMDA receptors with different sensitivities to magnesium and ifenprodil control the release of [14C]acetylcholine and [3H]spermidine from rat striatal slices in vitro.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aminoquinolines; Animals; Carbon Radioisotopes; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Magnesium; Magnesium Chloride; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 1994 |
Autoradiographic distribution and characteristics of high- and low-affinity polyamine-sensitive [3H]ifenprodil sites in the rat brain: possible relationship to NMDAR2B receptors and calmodulin.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Calmodulin; Hippocampus; Imidazoles; Male; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sepharose; Spermidine; Spermine; Sulfonamides; Tissue Distribution; Trifluoperazine; Tritium | 1994 |
Synergism between the NMDA receptor antagonistic effects of ifenprodil and the glycine antagonist, 7-chlorokynurenate, in vivo.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Synergism; Glycine; Injections; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1994 |
Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytosol; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine | 1993 |
Spermine promotes the survival of primary cultured brain neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebellum; Hippocampus; Neurons; Piperidines; Putrescine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1993 |
Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Arginine; Base Sequence; Binding Sites; Cell Line; Cloning, Molecular; Dizocilpine Maleate; DNA Primers; Excitatory Amino Acid Antagonists; Genetic Variation; Humans; Kidney; Kinetics; Macromolecular Substances; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Piperidines; Polymerase Chain Reaction; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Spermidine; Transfection | 1996 |
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E | 1997 |
Modulation of the N-methyl-D-aspartate receptor by haloperidol: NR2B-specific interactions.
Topics: Amino Acid Sequence; Binding, Competitive; Chimera; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Humans; Mutagenesis, Site-Directed; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine | 1998 |
Protective effects of ifenprodil against glutamate-induced neurotoxicity in cultured retinal neurons.
Topics: Animals; Cell Death; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Retina; Spermidine | 2000 |
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.
Topics: Animals; Brain; Cell Line; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Humans; Kinetics; Mice; Mutation; Phenols; Piperidines; Protein Structure, Tertiary; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Spermidine | 2001 |
Effect of multiple ifenprodil or spermidine treatment on social recognition in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Injections, Intraperitoneal; Male; Memory, Short-Term; Piperidines; Rats; Rats, Wistar; Recognition, Psychology; Spermidine | 2002 |
Spermidine attenuates the inhibitory effect of ethanol on NMDA-induced neurotoxicity.
Topics: Analysis of Variance; Animals; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; N-Methylaspartate; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermidine | 2002 |
Effects of acamprosate and some polyamine site ligands of NMDA receptor on short-term memory in rats.
Topics: Acamprosate; Administration, Oral; Animals; Biguanides; Dose-Response Relationship, Drug; Drug Interactions; Male; Memory, Short-Term; Motor Activity; Piperidines; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sleep; Spermidine; Taurine | 2002 |
Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil.
Topics: Agmatine; Animals; Biguanides; Binding Sites; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 2002 |
Prenatal ethanol exposure modifies [3H]MK-801 binding to NMDA receptors: spermidine and ifenprodil.
Topics: Alternative Splicing; Animals; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Female; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 2003 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizocilpine Maleate; Drug Therapy, Combination; Injections, Intraventricular; Male; Memory Disorders; Mice; N-Methylaspartate; Olfactory Bulb; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine; Time Factors | 2004 |
Influence of ions, hydration, and the transcriptional inhibitor P4N on the conformations of the Sp1 binding site.
Topics: Base Sequence; Binding Sites; Cobalt; Consensus Sequence; Crystallization; Crystallography, X-Ray; DNA; Ions; Ligands; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Phenyl Ethers; Piperidines; Polyethylene Glycols; Sp1 Transcription Factor; Spermidine; Transcription, Genetic; Water | 2005 |
Participation of hippocampal ionotropic glutamate receptors in histamine H(1) antagonist-induced memory deficit in rats.
Topics: Animals; Concanavalin A; Cycloserine; Dioxoles; Dose-Response Relationship, Drug; Electroencephalography; Fourier Analysis; GluK2 Kainate Receptor; Hippocampus; Histamine H1 Antagonists; Injections; Male; Maze Learning; Mental Recall; Orientation; Piperidines; Pyrilamine; Pyrrolidinones; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Histamine H1; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Signal Processing, Computer-Assisted; Spermidine; Spermine; Theta Rhythm | 2008 |
Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures.
Topics: Aging; Animals; Animals, Newborn; Ethanol; Female; Hippocampus; Male; Organ Culture Techniques; Piperidines; Propidium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Spermidine; Substance Withdrawal Syndrome | 2008 |
Mechanistic studies of displacer-protein binding in chemically selective displacement systems using NMR and MD simulations.
Topics: Chromatography, Liquid; Chymotrypsin; Magnetic Resonance Spectroscopy; Models, Molecular; Piperidines; Protein Binding; Protein Structure, Tertiary; Quinolines; Ribonuclease, Pancreatic; Spermidine | 2009 |
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Valine | 2010 |
Polyaminergic agents modulate contextual fear extinction in rats.
Topics: Animals; Biguanides; Conditioning, Classical; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Male; Neuropsychological Tests; Nootropic Agents; Piperidines; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine | 2010 |
Inhibition of the polyamine system counteracts β-amyloid peptide-induced memory impairment in mice: involvement of extrasynaptic NMDA receptors.
Topics: Amyloid beta-Peptides; Animals; Biguanides; Binding Sites; Cell Nucleus; Dendritic Spines; Exploratory Behavior; Hippocampus; Male; Memory Disorders; Mice; Nerve Tissue Proteins; Peptide Fragments; Piperidines; Polyamines; Receptors, N-Methyl-D-Aspartate; Spermidine; Synapses | 2014 |