spermidine has been researched along with eflornithine in 367 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 152 (41.42) | 18.7374 |
| 1990's | 139 (37.87) | 18.2507 |
| 2000's | 50 (13.62) | 29.6817 |
| 2010's | 20 (5.45) | 24.3611 |
| 2020's | 6 (1.63) | 2.80 |
| Authors | Studies |
|---|---|
| Twentyman, PR; Wallace, HM; Wright, KA | 1 |
| Scott, RE; Wang, H | 1 |
| Johnson, LR; Wang, JY | 3 |
| Allegrini, PR; Amacker, H; Bernasconi, R; Fagg, GE; Martin, P; Sauer, D | 1 |
| Di Giorgio, RM; Fabiano, C; Ientile, R; Macaione, S; Merendino, RA | 1 |
| Badger, B; Demers, L; Manni, A; Martel, J | 1 |
| Ask, A; Heby, O; Persson, L | 1 |
| Holm, I; Jänne, OA; Pegg, AE; Shantz, LM | 1 |
| Gunnia, UB; Thomas, T; Thomas, TJ | 1 |
| Bachrach, U; Glantz, L; Nates, JL; Shapira, Y; Shohami, E; Trembovler, V | 1 |
| Bareyal-Leyser, A; Diveley, RR; Mitchell, JL | 1 |
| Arcot, SS; Gillespie, MN; Haven, CA; Olson, JW | 1 |
| Boor, PJ; Tipnis, UR | 1 |
| Coward, JK; Lakanen, JR; Pegg, AE | 1 |
| Mann, RA; Singh, AB; Singh, M; Thomas, T; Thomas, TJ | 1 |
| Basu, HS; Csokan, PP; Delcros, JG; Feuerstein, BG; Marton, LJ; Sturkenboom, MC; Szollosi, J | 1 |
| Enomoto, M; Kinoshita, A; Nishida, Y; Pan, HO; Suzuki, F; Takigawa, M | 1 |
| Johnson, LR; McCormack, SA; Viar, MJ; Wang, JY | 1 |
| Herbst, EJ; Koza, RA | 1 |
| Koike, T; Shibusawa, M; Tsunoda, A; Tsunoda, Y; Yasuda, N | 1 |
| Carper, SW; Chen, JR; Fuller, DJ; Gerner, EW; Harari, PM; Tome, ME | 1 |
| Wang, M | 1 |
| Alunda, JM; Balaña-Fouce, R; Escribano, MI | 1 |
| Folk, JE; Hershey, JW; Park, MH; Smit-McBride, Z; Wolff, EC | 1 |
| Newman, PS; Olson, JW; Soltis, EE | 1 |
| Fredholm, BB; Lerner, UH; Ljunggren, O | 1 |
| Ilett, KF; Martin, RL; Minchin, RF; Raso, A | 1 |
| Busselen, P | 1 |
| Demers, L; Kim, I; Lynch, J; Manni, A | 1 |
| Berthélémy, P; Nicolet, T; Pradayrol, L; Scemama, JL; Seva, C; Vaysse, N | 1 |
| Alison, MR; Emons, VE; Hill, SA; Maghsoudloo, M; Murphy, GM; Sarraf, CE | 1 |
| Fike, JR; Gobbel, GT; Lamborn, K; Marton, LJ; Seilhan, TM | 1 |
| de Belleroche, J; Reed, LJ | 1 |
| Gunnia, UB; Seibold, JR; Thomas, T; Thomas, TJ | 1 |
| Ganem, B; Naficy, S; Nagarajan, S; Pegg, AE | 1 |
| Kovacs, JA; Lipschik, GY; Masur, H | 1 |
| Messner, RP; Thomas, TJ | 1 |
| Koyama, H; Matsui-Yuasa, I; Morii, H; Morisawa, S; Nishizawa, Y; Otani, S; Tahara, H | 1 |
| Bitonti, AJ; Byers, TL; Cross-Doersen, DE; McCann, PP; Wright, PS | 1 |
| Bardocz, S; Brown, DS; Grant, G; Pusztai, A; Stewart, JC; Watt, WB | 1 |
| Fairlamb, AH; Hunter, KJ; Strobos, CA | 1 |
| Autelli, R; Heby, O; Holm, I; Persson, L | 1 |
| Eterović, VA; Ferchmin, PA | 2 |
| Igarashi, K; Ito, K | 1 |
| Heby, O; Nicander, B; Oredsson, SM | 1 |
| Eloranta, TO; Hyvönen, T; Khomutov, AR; Khomutov, RM; Lapinjoki, S | 1 |
| Borghgraef, R; De Smedt, H; Geuns, J; Parys, JB; Van Den Bosch, L | 1 |
| Aisemberg, GO; Grotewold, E; Judewicz, ND; Taccioli, GE | 1 |
| Gallo, MA; MacKenzie, SA; Thomas, T | 1 |
| Welsh, N | 1 |
| Bartholomew, M; Demers, L; Glikman, PL; Manni, A | 1 |
| Gerarden, T; Pfaller, MA; Riley, J | 2 |
| Dunzendorfer, U; Knöner, M | 1 |
| Campbell, RM; Scanes, CG | 1 |
| Crozat, A; Ihalainen, R; Jänne, OA; Laitinen, PH; Madhubala, R; Pajunen, A; Pegg, AE; Stanley, B | 1 |
| Manchester, KL; Marais, A | 1 |
| Seidel, ER; Snyder, RG | 1 |
| Huben, RP; Pegg, AE; Pine, MJ | 1 |
| Igarashi, K; Ito, E; Kashiwagi, K; Sakamaki, Y; Terao, K | 1 |
| Hayashi, S; Murakami, Y; Nishiyama, M | 1 |
| Bukin, YV; Khomutov, AR; Khomutov, RM; Kramer, DL; Porter, CW | 1 |
| Bacchi, CJ; Bitonti, AJ; Garofalo, J; Hannan, JC; McCann, PP; Santana, A | 1 |
| Baylin, SB; Casero, RA; Celano, P | 1 |
| Giffin, BF; McCann, PP | 1 |
| Alhonen, L; Eloranta, T; Hirvonen, A; Hyvönen, T; Jänne, J | 1 |
| Heby, O; Holm, I; Persson, L; Stjernborg, L | 1 |
| Borghgraef, R; De Smedt, H; Geuns, J; Van den Bosch, L | 1 |
| Hyvönen, T | 1 |
| Horn, Y; Marton, LJ; Spigel, L | 1 |
| Ilett, KF; Martin, RL; Minchin, RF | 1 |
| Brasitus, TA; Dudeja, PK; Halline, AG | 1 |
| Oyasu, R; Rademaker, A; Seidenfeld, J; Uchida, K | 1 |
| Cleffmann, U; Creutzfeldt, W; Fölsch, UR; Löser, C; Nustede, R | 1 |
| Park, MH | 2 |
| Berchtold, CM; Casero, RA; Celano, P; Giardiello, FM | 1 |
| Snyder, RD | 2 |
| Casero, RA; Denstman, SC; Ervin, SJ | 1 |
| Andersen, B; Lundgren, DW; Moore, JJ; Moore, RM | 1 |
| Ekker, M; Sourkes, TL | 1 |
| Dascombe, MJ; Haegele, KD | 1 |
| Autuori, F; Beninati, S; Cocuzzi, ET; Folk, JE; Piacentini, M | 1 |
| Hollingdale, MR; McCann, PP; Sjoerdsma, A | 1 |
| Clark, RS; McGovern, KA; Pegg, AE | 1 |
| Dias, JA; Swift, TA | 1 |
| Gerner, EW; Glass, JR | 2 |
| Baylin, SB; Casero, RA; Go, B; Luk, GD; Smith, J; Theiss, HW | 1 |
| Meilhoc, E; Moutin, MJ; Osborne, HB; Romani, BH | 1 |
| Gerner, EW; Mamont, PS | 1 |
| Boldizsár, M; Holczinger, L; Kremmer, T | 1 |
| Ehrke, MJ; Eppolito, C; Mihich, E; Porter, CW | 1 |
| Inaba, M; Ishimura, E; Matsui-Yuasa, I; Morii, H; Morisada, S; Morisawa, S; Nishizawa, Y; Otani, S; Yukioka, K; Yukioka, M | 1 |
| Green, CD; Hoggard, N | 1 |
| Bremner, AF; Coombs, GH; Lockwood, BC; North, MJ | 1 |
| Berger, FG; Porter, CW | 1 |
| Bacchi, CJ; Giffin, BF; McCann, PP | 1 |
| Algranati, ID; Burrone, OR; Cafferata, EG; Ferrer, MM; Medrano, EE | 1 |
| Hammond, JM; Hsu, CJ; Manni, A; Wright, C | 1 |
| Bergeron, RJ; Ganis, B; Kramer, DL; Marton, LJ; Porter, CW; Vinson, T | 1 |
| Parra, SC; Thet, LA | 1 |
| Emmett, K; Kaur, K; McCann, PP; Sjoerdsma, A; Ullman, B | 1 |
| Deen, DF; Dewey, WC; Feuerstein, BG; Marton, LJ; Mivechi, NF | 1 |
| Caldarera, CM; Carati, D; Flamigni, F; Rossoni, C; Stefanelli, C | 1 |
| Gallo, CJ; Herbst, EJ; Koza, RA | 1 |
| Bolkenius, FN; Seiler, N | 2 |
| Fuller, DJ; Gerner, EW | 1 |
| Bernhardt, A; Gerner, EW; Mamont, PS; Siat, M | 1 |
| Bondy, SC; Komulainen, H | 1 |
| Carson, DA; Kubota, M; Yamanaka, H | 1 |
| Alhonen-Hongisto, L; Jänne, J; Laine, R; Leinonen, P | 1 |
| Ahmed, SR; Badger, B; Demers, LM; Manni, A; Wright, C | 1 |
| Byers, TL; Kameji, R; Pegg, AE; Rannels, DE | 1 |
| Davis, G; Demers, LM; Luk, GD; Manni, A; Wright, C | 1 |
| Aslam, M; Gillham, B; Jones, M; Nicholson, S | 1 |
| Assaraf, YG; Bachrach, U; Golenser, J; Messer, G; Spira, DT | 1 |
| Endoh, F; Fujimoto, S; Igarashi, K; Koike, S; Kokubun, M; Ohta, M; Okui, K; Shrestha, RD; Togawa, Y | 1 |
| Bacchi, CJ; Cerami, A; Fairlamb, AH; Henderson, GB | 1 |
| Deen, DF; Hunter, KJ; Marton, LJ | 1 |
| Goldstone, AD; Koenig, H; Lu, CY; Trout, JJ | 1 |
| Gerhart, F; Knodgen, B; Sarhan, S; Seiler, N | 1 |
| Dowling, RH; Hosomi, M; Lirussi, F; Murphy, GM; Stace, NH; Vaja, S | 1 |
| Ahmed, SR; Badger, B; Luk, G; Manni, A; Santner, SJ; Wright, C | 1 |
| Heby, O; Holm, I; Persson, L | 1 |
| Baylin, SB; Casero, RA; Celano, P; Giardiello, FM; Nelkin, BD | 1 |
| Badger, B; Bartholomew, M; Demers, L; Manni, A; Wright, C | 1 |
| Garewal, HS; Gerner, EW; Roe, D; Sampliner, RE | 1 |
| Bazzani, C; Bertolini, A; Genedani, S; Piccinini, G; Tagliavini, S | 1 |
| Guzman, C; Hamilton, JR; MacLeod, RJ | 1 |
| Etheredge, SB; Humphreys, MH; Lin, SY; Marton, LJ; Ribstein, J | 1 |
| Park, MH; Wolff, EC | 1 |
| Bjornsson, TD; Dryjski, M; Korner, G; Kuo, BS | 1 |
| Abe, E; Hayashi, T; Shinki, T; Suda, T; Tanaka, H | 1 |
| Ganem, B; Nagarajan, S; Pegg, AE | 1 |
| Bacchi, CJ; Yarlett, N | 1 |
| Alhonen-Hongisto, L; Levin, VA; Marton, LJ | 1 |
| Homma, Y; Numata, I; Oyasu, R; Ozono, S; Seidenfeld, J | 1 |
| Kufe, DW; Shafman, T; Watanabe, T | 1 |
| Bergeron, RJ; Cavanaugh, PF; Ganis, B; Kelly, E; Porter, CW; Stolowich, N | 1 |
| Franzen, MA; Mitchell, JL; Qasba, P; Stofko, RE | 1 |
| Pegg, AE; Shirahata, A | 1 |
| Königk, E; Putfarken, B | 1 |
| Seidenfeld, J | 1 |
| Jänne, J; Käpyaho, K; Kousa, M; Lauharanta, J; Linnamaa, K; Mustakallio, K | 1 |
| Bacchi, CJ; Clarkson, AB; McCann, PP; Mellow, GH; Nathan, HC; Sjoerdsma, A | 1 |
| Jänne, J; Käpyaho, K; Kariniemi, AL; Virtanen, I | 1 |
| Hölttä, E; Hovi, T; Jänne, J; Vaheri, A; Vartio, T | 1 |
| Chambaz, EM; Duperray, A; Madani, C | 1 |
| Tyms, AS; Williamson, JD | 1 |
| Coffino, P; Marton, LJ; McConlogue, LC | 1 |
| Fields, A; Gibson, W; Irmiere, A; LaFemina, R; van Breemen, R | 1 |
| Fout, GS; Mapoles, JE; Medappa, KC; Rueckert, RR | 1 |
| Gillin, FD; McCann, PP; Reiner, DS | 1 |
| Deen, DF; Hung, DT; Marton, LJ; Shafer, RH | 1 |
| Diekema, KA; Kingsnorth, AN; Malt, RA; McCann, PP; Russell, WE | 1 |
| Jänne, J; Käpyaho, K; Lauharanta, J | 2 |
| Kelly, M; McCann, PP; Schindler, J | 1 |
| Belleville, F; Brossat, B; Metz, R; Nabet, P; Straczek, J | 1 |
| Covey, DF; Fair, WR; Heston, WD; Kadmon, D | 1 |
| Bethell, DR; Erwin, BG; Pegg, AE | 1 |
| Kufe, D; Shafman, T; Sugiura, M | 1 |
| Mamont, PS; Rudkin, BB; Seiler, N | 1 |
| Griffin, J; Kufe, D; Mitchell, T; Shafman, T; Sugiura, M | 1 |
| Alhonen-Hongisto, L; Deen, DF; Marton, LJ | 1 |
| Cavanaugh, PF; Pavelic, ZP; Porter, CW | 1 |
| Manni, A; Wright, C | 1 |
| Alhonen-Hongisto, L; Elo, H; Fagerström, R; Jänne, J; Laine, R | 1 |
| Griffin, J; Kufe, DW; Mitchell, T; Shafman, T | 1 |
| Heby, O; Kanje, M; Oredsson, SM | 1 |
| Bartolome, J; Persons, D; Slotkin, TA; Whitmore, WL | 1 |
| Igarashi, K; Morris, DR | 1 |
| Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW | 1 |
| Bergeron, RJ; Casero, RA; Porter, CW | 1 |
| Pegg, AE | 1 |
| Benrezzak, O; Morisset, J | 1 |
| Anehus, S; Heby, O; Oredsson, S | 1 |
| Alhonen-Hongisto, L; Jänne, J | 1 |
| Deen, DF; Marton, LJ; Seidenfeld, J | 1 |
| Gray, JW; Marton, LJ; Seidenfeld, J | 1 |
| Fozard, JR; Grove, J; Prakash, NJ | 1 |
| Alhonen-Hongisto, L; Jänne, J; Seppänen, P | 1 |
| Fowler, SK; Nishioka, K; Sunkara, PS | 1 |
| Bethell, DR; Pegg, AE | 1 |
| Grove, J; Joder-Ohlenbusch, AM; Mamont, PS; Nussli, M | 1 |
| Bethell, DR; Hibasami, H; Matsui, I; Pegg, AE | 1 |
| Erwin, BG; Florini, JR; Pegg, AE; Richman, RA; Stoscheck, CM | 1 |
| Jänne, J; Käpyaho, K; Linnamaa, K | 1 |
| Seppänen, P | 1 |
| Boutwell, RK; Simsiman, RC; Takigawa, M; Verma, AK | 1 |
| Barnes, GA; Bartolome, J; Lerea, L; Seidler, FJ; Slotkin, TA; Trepanier, PA; Weigel, SJ; Whitmore, WL | 1 |
| Deen, DF; Marton, LJ; Oredsson, SM; Tofilon, PJ | 1 |
| McCann, PP; Pegg, AE | 1 |
| Hougaard, DM; Larsson, LI | 1 |
| Blanner, P; Israel, M; Johnson, LR; McCormack, SA; Zimmerman, BJ | 1 |
| Bardocz, S | 1 |
| el-Fakahany, EE; Hu, J; Mahmoud, MI | 1 |
| Gritli-Linde, A; Linde, A; Ruch, JV | 1 |
| Afzal, V; Feeney, L; Wolff, S | 1 |
| Cipolla, B; Corbel, L; Guillé, F; Lobel, B; Moulinoux, JP; Quemener, V; Staerman, F | 1 |
| Golden, K; Rillema, JA | 1 |
| Maghsoudloo, M; Murphy, GM; Santos, AA; Stubbs, AP; Wilkinson, ML | 1 |
| Lessard, M; Poulin, R; Singh, SM; Zhao, C | 1 |
| Eloranta, TO; Hyvönen, T; Keinänen, TA; Khomutov, AR; Khomutov, RM | 1 |
| Abraham, JH; Schousboe, A; Seiler, N | 1 |
| Iqbal, Z; Siddiqui, F | 1 |
| Johnson, LR; Viar, MJ; Wang, JY | 1 |
| Davies, PJ; Johnson, LR; McCormack, SA; Tague, L; Viar, MJ; Wang, JY | 1 |
| Byers, TL; Hu, RH; Pegg, AE; Wechter, RS | 1 |
| Bucht, E; Larsson, R; Nygren, P; Sjöholm, A; Theodorsson, E | 1 |
| Boor, PJ; Gutkowska, J; Haile, C; Tipnis, UR | 1 |
| Byers, TL; Coward, JK; Lakanen, JR; Pegg, AE | 1 |
| Cremades, A; Galindo, JD; Peñafiel, R; Sánchez-Capelo, A; Tovar, A | 1 |
| Thomas, T; Thomas, TJ | 1 |
| Alberts, DS; Einspahr, J; Emerson, SS; Gerner, EW; Meshkinpour, H; Meyskens, FL; Pelot, D; Shassetz, LR | 1 |
| Alunda, JM; Balaña-Fouce, R; Carrera, L | 1 |
| Blachowski, S; Grzelkowska, K; Interewicz, B; Kasterka, M; Motyl, T; Orzechowski, A | 1 |
| Aziz, SM; Endean, ED; Toursarkissian, B | 1 |
| Bristol, LA; Guidotti, A; Lombardi, G; Manev, H; Szekely, AM | 1 |
| Carboni, S; Carter, C; Fage, D; Scatton, B; Voltz, C | 1 |
| Berezov, TT; Fedoronchuk, TV; Ianson, IaIa; Lidak, MIu; Lulle, IZh; Siatkin, SP | 1 |
| Higaki, I; Kinoshita, H; Matsui-Yuasa, I; Otani, S; Terakura, M | 1 |
| Brock, M; Henley, CM | 1 |
| McGarrity, TJ; Peiffer, LP | 1 |
| Schroeder, KK; Snyder, RD | 1 |
| Blachowski, S; Grzelkowska, K; Kasterka, M; Motyl, T; Sysa, P | 1 |
| Callery, PS; Egorin, MJ; Rosen, DM; Simon, MA; Yuan, ZM | 1 |
| Lövkvist, E; Persson, L; Stjernborg, L | 1 |
| Johnson, LR; McCormack, SA; Scott, RE; Tzen, CY; Viar, MJ; Wang, H; Wang, JY | 1 |
| Casero, RA; Fuller, DJ; Gerner, EW; Kurtts, TA | 1 |
| Arkhammar, P; Berggren, PO; Bokvist, K; Hallberg, A; Nilsson, T; Rorsman, P; Sjöholm, A; Welsh, M; Welsh, N | 1 |
| Chung, DH; Evers, BM; Herndon, DN; Huang, KF; Thompson, JC; Townsend, CM | 1 |
| Hoffman, JL; Parekh, VV; Younoszai, MK | 1 |
| Hara, A; Kojima, T; Mori, H; Sawada, H; Tanaka, T | 1 |
| Johnson, LR; McCormack, SA; Viar, MJ | 1 |
| Meizel, S; Turner, KO | 1 |
| Fogel-Petrovic, MF; Porter, CW; Shappell, NW | 1 |
| Ask, A; Heby, O; Persson, L; Seiler, N | 1 |
| Hayashi, S; Igarashi, K; Iwashita, S; Kameji, T; Kanamoto, R | 1 |
| Bedoya, AM; Hernandez, SM; Isola, EL; Lammel, EM; Rilo, MC; Schwarcz de Tarlovsky, MN | 1 |
| Pegg, AE; Poulin, R | 1 |
| Hynd, PI; Nancarrow, MJ | 1 |
| Bianchi, L; Brown, AM; Ficker, E; Lundgren, DW; Roy, ML; Taglialatela, M | 1 |
| Fredlund, JO; Oredsson, SM | 1 |
| El Ghachtouli, N; Gianinazzi, S; Martin-Tanguy, J; Paynot, M | 1 |
| Anzon, E; Bernelli-Zazzera, A; Desiderio, MA; Pogliaghi, G; Radice, L; Tacchini, L | 1 |
| Hughes, AD; Ibrahim, J; Schachter, M; Sever, PS | 1 |
| Caprini, M; Ciani, E; Contestabile, A; Facchinetti, F; Sparapani, M; Virgili, M | 1 |
| Clarkson, AB; Merali, S | 1 |
| Gupta, R; Khurana, N; Rajam, MV; Saxena, RK | 1 |
| Fölsch, UR; Löser, C; Starp, F | 1 |
| Gerner, EW; Ignatenko, NA | 1 |
| Coker, NJ; Henley, CM; Kim, HJ | 1 |
| Chen, KY; Chen, ZP | 1 |
| Johnson, LR; McCormack, SA; Santos, MF; Viar, MJ | 1 |
| Patel, AR; Wang, JY | 1 |
| Hu, RH; Pegg, AE | 1 |
| Hayashi, S; Hayashi, T; Matsufuji, S | 1 |
| Douaud, F; Havouis, R; Le Roch, N; Moulinoux, JP; Renault, J; Seiler, N; Vaultier, M | 1 |
| Johnson, LR; Li, J; Patel, AR; Shi, HJ; Viar, MJ; Wang, JY | 1 |
| Barbieri, D; Franceschi, C; Ghiaroni, S; Marverti, G; Monti, MG; Pernecco, L | 1 |
| Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A | 1 |
| George, K; Gilliard, G; Megosh, L; O'Brien, TG; Peralta Soler, A | 1 |
| Beyaert, R; Denecker, T; Penning, LC; Schipper, RG; Vandenabeele, P; Vercammen, D; Verhofstad, AA | 1 |
| Kidd, M; Miu, K; Modlin, IM; Schmid, SW; Tang, LH | 1 |
| Doyle, K; Durbin, T; Emerson, S; Gerner, EW; Lagerberg, W; Meyskens, FL; Pelot, D | 1 |
| Bloch, KJ; Capano, G; Carter, EA; Dascoli, JA; Harmatz, PR; Schoenfeld, D | 1 |
| Geller, AM; Johnson, LR; Kotb, M; Langkamp-Henken, B; Viar, MJ | 1 |
| Baroni, T; Bellucci, C; Bosi, G; Carinci, P; Evangelisti, R; Valeno, V | 1 |
| Cannavò, L; Ginoprelli, T; Ientile, R; Macaione, S; Pedale, S | 1 |
| Adihkarakunnathu, S; Faaland, CA; Gallo, MA; Klinge, CM; Shah, N; Thomas, T; Thomas, TJ | 1 |
| Barbieri, D; Franceschi, C; Ghiaroni, S; Giuseppina Monti, M; Marverti, G; Moruzzi, MS | 1 |
| Bass, BL; Li, J; Li, L; Li, M; Rao, JN; Wang, JY | 1 |
| Boggs, SS; Deutsch, M; Grudziak, AG; Redgate, ES | 1 |
| Bernelli-Zazzera, A; Dansi, P; Desiderio, MA; Tacchini, L | 1 |
| Cullis, PM; Green, RE; Merson-Davies, L; Travis, N | 1 |
| Cleveland, JL; Dai, H; Kramer, DL; Murti, KG; Porter, CW; Yang, C | 1 |
| Arseneau, J; Demers, LM; George, T; Gersh, R; Jones, SE; Khandelwal, P; Manni, A; Mauger, D; O'Shaughnessy, JA | 1 |
| Honkanen, RE; Sjöholm, A | 1 |
| Haghighi, S; Pajunen, A; Pulkka, A; Veress, I | 1 |
| Golovina, VA; Li, L; Platoshyn, O; Wang, J; Wang, JY; Yuan, JX | 1 |
| Johnson, LR; Ray, RM; Viar, MJ; Yuan, Q | 1 |
| Collins, S; Rillema, JA; Williams, CH | 1 |
| Bass, BL; Li, L; Rao, JN; Wang, JY | 2 |
| Burns, MR; Cai, F; Carlson, CL; Devens, BH; O'Day, CL; Vanderwerf, SM; Webb, HK; Weeks, RS | 1 |
| Algranati, ID; Carrillo, C; Cejas, S; Ceriani, C; Cortés, M; González, NS; Huber, A | 1 |
| Gerner, EW; McLaren, CE; Meyskens, FL; Phung, M; Simoneau, AR | 1 |
| Ariyanayagam, MR; Davies, AJ; Hunter, KJ; Mastri, C; Thorborn, DE | 1 |
| Finbow, ME; Gilmour, SK; Hodgins, MB; McLean, P; Shore, L | 1 |
| Gaspar, T; Kevers, C; Tonon, G | 1 |
| Dai, YR; Galston, AW; Kaur-Sawhney, R | 1 |
| Galston, AW; Rajam, MV; Weinstein, LH | 1 |
| Galston, AW; Slocum, RD | 1 |
| Galston, AW; Kaur-Sawhney, R; Tiburcio, AF | 1 |
| Galston, AW; Kaur Sawhney, R; Shekhawat, NS | 1 |
| Galston, AW | 1 |
| Galston, AW; Rajam, MV | 1 |
| Burns, MR; Cai, F; Carlson, CL; Graminski, GF; Vanderwerf, SM; Webb, HK; Weeks, RS; Ziemer, JR | 1 |
| Algranati, ID; González, NS; Huber, A | 1 |
| Hawker, JR; Kelly, KA; Li, H; Meininger, CJ; Morris, SM; Wu, G | 1 |
| Medina, MA; Paz, JC; Sánchez-Jiménez, F | 1 |
| Alberts, DS; Bowden, GT; Einspahr, JG; Nelson, MA; Saboda, K; Warneke, J | 1 |
| Libertun, C; Thyssen, SM | 1 |
| Fallon, A; Fields, C; Fitzgerald, ME; Johnson, DA; Johnson, LR; Viar, MJ | 1 |
| Couée, I; El Amrani, A; Hennion, F; Hummel, I; Martin-Tanguy, J | 1 |
| Blanco, I; Danchev, N; Dot, J; Rodríguez-Alvarez, J | 1 |
| Blagbrough, IS; Carrington, S; Delcros, JG; Martin, B; Renault, J; Tomasi, S; Uriac, P | 1 |
| Fujiwara, K; Nagoshi, S; Ota, S | 1 |
| Alabadí, D; Carbonell, J; Fos, M; García-Martínez, JL; Nuez, F; Proaño, K | 1 |
| Du, H; Johnson, LR; Viar, MJ; Watsky, MA | 1 |
| Wang, HC; Wong, ML | 1 |
| Alexandrova, N; Berdynskykh, N; Chekhun, V; Gerner, E; Gogol, S; Ignatenko, N; Orlovsky, O; Tregubova, N; Zaletok, S | 1 |
| Casero, RA; Davidson, NE; Huang, Y; Pledgie, A | 1 |
| Calastrini, C; Dellavia, C; Ferioli, ME; Gagliano, N; Gioia, M; Moscheni, C; Stabellini, G | 1 |
| Bonafé, F; Caldarera, CM; Farruggia, G; Flamigni, F; Guarnieri, C; Muscari, C; Stanic, I; Stefanelli, C | 1 |
| Araki, N; Asakura, M; Kozaki, S; Nishimura, K; Ohnishi, Y; Samosomsuk, W; Shima, K; Yamasaki, S; Yanase, T | 1 |
| Baron, CB; Coburn, RF; Labelle, EF | 1 |
| Brissot, P; Gaboriau, F; Laupen-Chassay, C; Lescoat, G; Pasdeloup, N; Pierre, JL | 1 |
| Bruggeman, R; Demers, LM; Griffith, JW; Jun, JY; Manni, A; Verderame, MF; Washington, S | 1 |
| Belting, M; Cheng, F; Lilja, J; Mani, K; Persson, L; Sandgren, S; Svensson, K | 1 |
| Casero, RA; Hacker, A; Mackintosh, CA; Pegg, AE; Rider, JE; Woster, PM | 1 |
| Ando, A; Furuta, K; Igarashi, K; Ito, S; Kaneko, S; Maeda, M; Matsumura, M; Nishimura, K; Okuda-Ashitaka, E; Suzuki, M | 1 |
| Borzì, RM; Caldarera, CM; Cetrullo, S; Facchini, A; Flamigni, F; Guarnieri, C; Stanic', I; Tantini, B | 1 |
| Heby, O; Persson, L; Rentala, M | 1 |
| Alhonen, L; Cerrada-Gimenez, M; Grigorenko, N; Hyvönen, MT; Jänne, J; Keinänen, TA; Khomutov, AR; Sinervirta, R; Vepsäläinen, J | 1 |
| Blessington, B; Kaur, H; Kelly, JM; Taylor, MC; Wilkinson, SR | 1 |
| Cheng, PF; Ji, BS; Liu, GC; Ma, YF; Wang, CJ; Wang, MW; Wu, YL; Xie, SQ; Zhao, J | 1 |
| Palavan-Unsal, N; Tufekci, MA; Unal, M | 1 |
| Bhagyalakshmi, N; Venkatachalam, L | 1 |
| Bordallo, C; Bordallo, J; Cantabrana, B; de Boto, MJ; Hidalgo, A; Rubín, JM; Sánchez, M; Secades, L; Velasco, L | 1 |
| Bordallo, C; Bordallo, J; Cantabrana, B; Meana, C; Méndez, M; Sánchez, M; Secades, L; Velasco, L | 1 |
| Gupta, N; Liu, P; Zhang, H | 2 |
| Alhonen, L; Cerrada-Gimenez, M; Jänne, J; Keinänen, TA; Khomutov, AR; Pietilä, M; Pirinen, E; Uimari, A; Vuohelainen, S | 1 |
| Chai, TC; Li, M; Simard, JM; Sun, Y; Wang, JY | 1 |
| Gao, WY; Mei, ZH; Tian, ZY; Wang, CJ; Xie, SQ; Zhao, J | 1 |
| Bercovich, Z; Kahana, C; Landau, G; Park, MH | 1 |
| Blohm-Mangone, KA; Gerner, EW; Stringer, DE; Uemura, T | 1 |
| Chen, WP; Gerner, EW; LaFleur, BJ; McLaren, CE; Meyskens, FL; Thompson, PA; Wertheim, BC; Zell, JA | 1 |
| Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Kochetkov, SN; Simonian, A; Vepsäläinen, J; Weisell, J | 1 |
| Cui, YH; Gorospe, M; Liu, L; Rao, JN; Smith, A; Turner, DJ; Wang, JY; Xiao, L; Zou, T | 1 |
| Chen, WW; Hu, C; Li, RL; Lu, WB; Wang, J; Yang, YQ | 1 |
| Kano, Y; Konishi, F; Soda, K | 1 |
| Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Koponen, T; Pietilä, M; Vepsäläinen, J; Weisell, J | 1 |
| Barclay, JJ; Carrillo, C; Colombo, MI; Cueto, JA; Gottlieb, RA; Romano, PS; Vanrell, MC | 1 |
| Jennings, MW; Jurney, CH; Krick, EL; Lewis, JR; O'Brien, TG; Reiter, AM; Shofer, FS; Skorupski, KA | 1 |
| Madhubala, R; Roberts, S; Singh, AK; Ullman, B | 1 |
| Forte, A; Grossi, M; Hellstrand, P; Nilsson, BO; Persson, L; Swärd, K; Turczyńska, KM | 1 |
| Bavaria, MN; Bhattacharya, S; Johnson, LR; Ray, RM; Viar, MJ | 1 |
| Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Kochetkov, SN; Petit, M; Vepsäläinen, J; Weisell, J | 1 |
| Chen, CH; Chen, Y; Hsu, YC; Huang, YP; Lee, MJ; Lin, KL; Sie, MH; Tsai, YH; Wang, GJ | 1 |
| Anderson, RM; Mastracci, TL; Mirmira, RG; Robertson, MA | 1 |
| Alajbegovic, A; Albinsson, S; Forte, A; Grossi, M; Hellstrand, P; Nilsson, BO; Persson, L; Phanstiel, O; Rippe, C; Swärd, K | 1 |
| Fukui, T; Rikiyama, T; Soda, K; Takao, K | 1 |
| Bogacz, M; Dick, TP; Ebersoll, S; Günter, LM; Krauth-Siegel, RL | 1 |
| Igarashi, K; Mizuta, T; Murakami, T; Nishimura, K; Okamoto, M; Shibayama, T; Shibue, R; Tanaka, S; Toida, T; Yamaguchi, M; Yoshino, T | 1 |
| Eaton, MJ; Malpica-Nieves, CJ; Mayor, AM; Phanstiel, O; Rivera-Aponte, DE; Skatchkov, SN; Tejeda-Bayron, FA; Veh, RW | 1 |
| Cai, L; Jiang, XR; Li, XL; Wei, ZX; Zhao, XM | 1 |
| Casero, RA; DiAngelo, JR; Nowotarski, SL; Phanstiel, O; Stump, CL | 1 |
| Casero, RA; Foley, JR; Holbert, CE; Khomutov, AR; Khomutov, M; Rastkari, N; Stewart, TM; Tao, X; Zhai, RG | 1 |
5 review(s) available for spermidine and eflornithine
| Article | Year |
|---|---|
Polyamine metabolism and function.
Topics: Animals; Cell Cycle; Cell Differentiation; Cell Division; Eflornithine; Humans; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; S-Adenosylmethionine; Spermidine | 1982 |
The role of dietary polyamines.
Topics: Cadaverine; Cell Division; Diet; Digestive System; DNA; Eflornithine; Humans; Neoplasms; Protein Biosynthesis; Putrescine; RNA; Spermidine; Spermine | 1993 |
Molecular mechanisms of polyamine analogs in cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Eflornithine; Humans; Molecular Conformation; Neoplasms; Polyamines; Putrescine; Spermidine; Structure-Activity Relationship | 2005 |
Polyamine biosynthesis as a target to inhibit apoptosis of non-tumoral cells.
Topics: Amidines; Animals; Apoptosis; Biogenic Polyamines; Caspases; Cell Survival; Chondrocytes; Eflornithine; Humans; Indans; Myocytes, Cardiac; Ornithine Decarboxylase Inhibitors; Peptide Hydrolases; Putrescine; Signal Transduction; Spermidine | 2007 |
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Chagas Disease; Eflornithine; Enzyme Inhibitors; Glutathione; Humans; Leishmania; Leishmaniasis; Ornithine Decarboxylase Inhibitors; Robenidine; Spermidine; Spermidine Synthase; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African | 2007 |
7 trial(s) available for spermidine and eflornithine
| Article | Year |
|---|---|
Urinary polyamine levels in cancer patients treated with D,L-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Eflornithine; Female; Genital Neoplasms, Female; Humans; Male; Middle Aged; Polyamines; Prostatic Neoplasms; Putrescine; Random Allocation; Spermidine; Stomach Neoplasms; Time Factors | 1989 |
Dose de-escalation chemoprevention trial of alpha-difluoromethylornithine in patients with colon polyps.
Topics: Administration, Oral; Adult; Aged; Biogenic Polyamines; Colonic Polyps; Colorectal Neoplasms; Drug Administration Schedule; Eflornithine; Female; Humans; Intestinal Mucosa; Male; Middle Aged; Putrescine; Spermidine; Spermine | 1994 |
Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention.
Topics: Adult; Aged; Aged, 80 and over; Anticarcinogenic Agents; Audiometry; Colonic Neoplasms; Double-Blind Method; Eflornithine; Female; Hearing; Humans; Intestinal Mucosa; Male; Middle Aged; Polyamines; Putrescine; Spermidine; Spermine; Time Factors; Treatment Outcome | 1998 |
Alpha-difluoromethylornithine as treatment for metastatic breast cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Eflornithine; Female; Humans; Middle Aged; Neoplasm Staging; Polyamines; Putrescine; Receptors, Estrogen; Spermidine; Spermine; Time Factors | 1999 |
Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Eflornithine; Enzyme Inhibitors; Humans; Male; Polyamines; Prostate-Specific Antigen; Prostatic Neoplasms; Putrescine; Spermidine; Spermine | 2001 |
Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer.
Topics: Aged; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Biopsy; Cell Division; Eflornithine; Enzyme Inhibitors; Female; Humans; Immunoenzyme Techniques; Keratosis; Male; Mutation; Ornithine Decarboxylase Inhibitors; Photosensitivity Disorders; Proliferating Cell Nuclear Antigen; Risk Factors; Skin Neoplasms; Spermidine; Tumor Suppressor Protein p53 | 2002 |
Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma.
Topics: Adenoma; Aged; Anticarcinogenic Agents; Biomarkers, Pharmacological; Biopsy; Colonoscopy; Colorectal Neoplasms; Dinoprostone; Double-Blind Method; Drug Therapy, Combination; Eflornithine; Enzyme Inhibitors; Female; Humans; Intestinal Mucosa; Likelihood Functions; Logistic Models; Male; Middle Aged; Neoplasms, Second Primary; Polyamines; Putrescine; Rectum; Spermidine; Spermine; Sulindac; Time Factors; Treatment Outcome | 2010 |
355 other study(ies) available for spermidine and eflornithine
| Article | Year |
|---|---|
Effects of cyclosporin A and a non-immunosuppressive analogue, O-acetyl cyclosporin A, upon the growth of parent and multidrug resistant human lung cancer cells in vitro.
Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cell Line; Cell Survival; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Drug Resistance; Eflornithine; Humans; In Vitro Techniques; Lung Neoplasms; Putrescine; Spermidine; Spermine | 1992 |
Induction of c-jun independent of PKC, pertussis toxin-sensitive G protein, and polyamines in quiescent SV40-transformed 3T3 T cells.
Topics: 3T3 Cells; Alkaloids; Animals; Antigens, Polyomavirus Transforming; Cell Division; Cell Line, Transformed; Eflornithine; Gene Expression; Genes, jun; Genistein; GTP-Binding Proteins; Insulin; Isoflavones; Kinetics; Mice; Pertussis Toxin; Polyamines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Putrescine; Signal Transduction; Simian virus 40; Spermidine; Staurosporine; Tetradecanoylphorbol Acetate; Vanadates; Virulence Factors, Bordetella | 1992 |
Role of transglutaminase and protein cross-linking in the repair of mucosal stress erosions.
Topics: Animals; Cadaverine; Drug Combinations; Eflornithine; Gastric Mucosa; Male; Proteins; Rats; Rats, Inbred Strains; Spermidine; Stress, Physiological; Time Factors; Transglutaminases; Wound Healing | 1992 |
Differing effects of alpha-difluoromethylornithine and CGP 40116 on polyamine levels and infarct volume in a rat model of focal cerebral ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cerebral Infarction; Eflornithine; Magnetic Resonance Imaging; Male; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred F344; Spermidine; Spermine | 1992 |
Polyamines are involved in retinoic acid-mediated induction of tissue transglutaminase in human peripheral blood monocytes.
Topics: Cell Differentiation; Cells, Cultured; Centrifugation, Density Gradient; Chromatography, High Pressure Liquid; Eflornithine; Enzyme Induction; Humans; Macrophages; Monocytes; Putrescine; Spermidine; Transglutaminases; Tretinoin | 1992 |
Role of polyamines in the growth of hormone-responsive and -resistant human breast cancer cells in nude mice.
Topics: Animals; Breast Neoplasms; Cell Division; Drug Resistance; Drug Screening Assays, Antitumor; Eflornithine; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Polyamines; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1992 |
Increased survival of L1210 leukemic mice by prevention of the utilization of extracellular polyamines. Studies using a polyamine-uptake mutant, antibiotics and a polyamine-deficient diet.
Topics: Animals; Anti-Bacterial Agents; Biological Transport; Carbon Radioisotopes; Drug Resistance; Eflornithine; Extracellular Space; Female; Leukemia L1210; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitoguazone; Mutation; Polyamines; Sex Factors; Spermidine; Spermine; Tritium | 1992 |
Regulation of S-adenosylmethionine decarboxylase activity by alterations in the intracellular polyamine content.
Topics: Adenosylmethionine Decarboxylase; Animals; Cells, Cultured; Chlorocebus aethiops; CHO Cells; Cricetinae; Diamines; Eflornithine; Gene Expression Regulation; In Vitro Techniques; Ornithine Decarboxylase Inhibitors; Polyamines; Spermidine; Spermine; Spermine Synthase; Transcription, Genetic; Transfection | 1992 |
Reversal of the abnormal development of T cell subpopulations in the thymus of autoimmune MRL-lpr/lpr mice by a polyamine biosynthesis inhibitor.
Topics: Animals; Autoimmunity; CD4-CD8 Ratio; Disease Models, Animal; Eflornithine; Lupus Erythematosus, Systemic; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; T-Lymphocyte Subsets; Thymus Gland | 1992 |
Changes in brain polyamine levels following head injury.
Topics: Animals; Body Water; Brain; Cerebral Cortex; Eflornithine; Head Injuries, Closed; Male; Motor Activity; Posture; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine; Time Factors | 1992 |
Abnormal accumulation and toxicity of polyamines in a difluoromethylornithine-resistant HTC cell variant.
Topics: Animals; Biological Transport; Cell Survival; Drug Resistance; Eflornithine; Kinetics; Liver Neoplasms, Experimental; Neoplasm Proteins; Polyamines; Rats; Spermidine; Tumor Cells, Cultured | 1992 |
Polyamine transport and ornithine decarboxylase activity in hypoxic pulmonary artery smooth muscle cells.
Topics: Animals; Biological Transport; Blotting, Northern; Cattle; Cells, Cultured; Cycloheximide; Dactinomycin; Eflornithine; Kinetics; Muscle, Smooth, Vascular; Ornithine Decarboxylase; Oxygen; Pulmonary Artery; Spermidine | 1992 |
Inhibition of polyamine synthesis impairs the secretion of atrial natriuretic peptide.
Topics: Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Blood Pressure; Eflornithine; Injections, Intraperitoneal; Male; Myocardium; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Radioimmunoassay; Rats; Rats, Inbred Strains; Spermidine | 1992 |
alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines.
Topics: Animals; Cell Division; Cell Line, Transformed; Colonic Neoplasms; Eflornithine; Humans; Leukemia L1210; Methylation; Mice; Putrescine; Spermidine; Spermine; Spermine Synthase; Substrate Specificity; Tumor Cells, Cultured | 1992 |
Differential effects of polyamine homologues on the prevention of DL-alpha-difluoromethylornithine-mediated inhibition of malignant cell growth and normal immune response.
Topics: Animals; Cell Division; Cell Line; Concanavalin A; Cytotoxicity, Immunologic; Eflornithine; Isomerism; Lymphocyte Activation; Lymphoma; Male; Mast-Cell Sarcoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Polyamines; Putrescine; Spermidine; Spermine | 1992 |
Effect of polyamine depletion on chromatin structure in U-87 MG human brain tumour cells.
Topics: Brain Neoplasms; Cell Nucleus; Chromatin; Culture Media, Serum-Free; Deoxyribonuclease I; Eflornithine; Humans; Intracellular Fluid; Kinetics; Micrococcal Nuclease; Polyamines; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1992 |
Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro.
Topics: Animals; Cattle; Cell Division; Chick Embryo; DNA, Neoplasm; Eflornithine; Endothelium, Vascular; Melanoma, Experimental; Neovascularization, Pathologic; Ornithine Decarboxylase; Putrescine; Spermidine | 1990 |
Polyamines and ornithine decarboxylase during repair of duodenal mucosa after stress in rats.
Topics: Animals; DNA; Duodenum; Eflornithine; Intestinal Mucosa; Male; Ornithine Decarboxylase; Polyamines; Proteins; Putrescine; Rats; Rats, Inbred Strains; RNA; Spermidine; Spermine; Stress, Physiological | 1991 |
Stimulation of proximal small intestinal mucosal growth by luminal polyamines.
Topics: Animals; Cell Line; DNA; DNA Replication; Duodenum; Eflornithine; Intestinal Mucosa; Jejunum; Kinetics; Male; Ornithine Decarboxylase; Proteins; Rats; Rats, Inbred Strains; RNA; Spermidine; Spermine; Thymidine; Tritium | 1991 |
Deficiencies in DNA replication and cell-cycle progression in polyamine-depleted HeLa cells.
Topics: Cell Cycle; Cell Division; Cell Nucleus; DNA Polymerase II; DNA Replication; Eflornithine; HeLa Cells; Humans; Nuclear Proteins; Polyamines; Putrescine; S Phase; Spermidine; Spermine; Thymidine Monophosphate; Tritium | 1992 |
Reduced growth rate of dimethylhydrazine-induced colon tumors in rats.
Topics: Animals; Body Weight; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Male; Mitomycin; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1992 |
Polyamine catabolism in rodent and human cells in culture.
Topics: Animals; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Eflornithine; Hot Temperature; Humans; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Rats; Spermidine; Spermine; Tumor Cells, Cultured | 1991 |
[Inhibition by polyamine biosynthesis inhibitor DFMO of the growth of transplanted human colon cancer in nude mice].
Topics: Animals; Bone Marrow; Cecal Neoplasms; Colonic Neoplasms; Eflornithine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Putrescine; Spermidine | 1991 |
Leishmania infantum: polyamine biosynthesis and levels during the growth of promastigotes.
Topics: Animals; Decarboxylation; Diminazene; Dogs; Eflornithine; Leishmania donovani; Methionine; Ornithine; Polyamines; Putrescine; Spermidine; Spermine; Trypanocidal Agents | 1991 |
Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine.
Topics: Animals; Cadaverine; Cells, Cultured; Chromatography, Ion Exchange; Cricetinae; Eflornithine; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Structure; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Periodic Acid; Puromycin; RNA-Binding Proteins; Spermidine; Substrate Specificity | 1991 |
Polyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension.
Topics: Acetylcholine; Animals; Aorta; Arteries; Blood Pressure; Body Weight; Desoxycorticosterone; Dose-Response Relationship, Drug; Eflornithine; Heart; Heart Rate; Hypertension; Male; Muscle, Smooth, Vascular; Nephrectomy; Nitroprusside; Norepinephrine; Organ Size; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Serotonin; Spermidine; Spermine; Tail; Time Factors; Vasoconstriction | 1991 |
On the role of polyamines in bone resorption induced by parathyroid hormone.
Topics: Animals; Bone Neoplasms; Bone Resorption; Calcium; Eflornithine; Mice; Ornithine Decarboxylase; Parathyroid Hormone; Polyamines; Sarcoma, Experimental; Skull; Spermidine; Spermine; Tumor Cells, Cultured | 1991 |
Evidence for the existence of distinct transporters for the polyamines putrescine and spermidine in B16 melanoma cells.
Topics: Affinity Labels; Biological Transport; Carrier Proteins; Eflornithine; Kinetics; Melanoma, Experimental; Photochemistry; Putrescine; Spermidine; Tumor Cells, Cultured | 1991 |
Polyamines and the calcium paradox in rat hearts.
Topics: Animals; Calcium; Chromatography, High Pressure Liquid; Eflornithine; Egtazic Acid; Female; Heart; Myocardium; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine; Systole | 1991 |
Polyamine involvement in the secretion and action of TGF-alpha in hormone sensitive human breast cancer cells in culture.
Topics: Breast Neoplasms; Cell Division; Eflornithine; Estrogens; Humans; In Vitro Techniques; Neoplasms, Hormone-Dependent; Polyamines; Putrescine; Serum Albumin, Bovine; Spermidine; Spermine; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1991 |
Putrescine and spermidine uptake is regulated by proliferation and dexamethasone treatment in AR4-2J cells.
Topics: Animals; Biological Transport; Cell Division; Cell Line; Cells, Cultured; Dexamethasone; Eflornithine; Kinetics; Male; Pancreas; Pancreatic Neoplasms; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1991 |
Effect of alpha-difluoromethylornithine on the polyamine levels and proliferation in two transplantable tumours.
Topics: Animals; Cell Division; Cell Nucleus; Eflornithine; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred CBA; Microscopy, Electron; Neoplasm Transplantation; Organelles; Polyamines; Putrescine; Sarcoma, Experimental; Spermidine; Spermine | 1991 |
Modification of radiation-induced brain injury by alpha-difluoromethylornithine.
Topics: Animals; Blood-Brain Barrier; Brachytherapy; Brain; Brain Edema; Dogs; Eflornithine; Female; Infusions, Intravenous; Iodine Radioisotopes; Male; Putrescine; Radiation Injuries, Experimental; Spermidine | 1991 |
Induction of ornithine decarboxylase in cerebral cortex by excitotoxin lesion of nucleus basalis: association with postsynaptic responsiveness and N-methyl-D-aspartate receptor activation.
Topics: Animals; Basal Ganglia; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Eflornithine; Enzyme Induction; Excitatory Amino Acid Antagonists; Glutamic Acid; Ibotenic Acid; Kainic Acid; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxazoles; Pentobarbital; Phosphatidylinositol Phosphates; Phosphatidylinositols; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Substantia Innominata; Synapses | 1990 |
Restoration of the DNA binding activity of estrogen receptor in MRL-lpr/lpr mice by a polyamine biosynthesis inhibitor.
Topics: Animals; DNA; Down-Regulation; Eflornithine; Female; Lupus Erythematosus, Systemic; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Putrescine; Receptors, Estrogen; Spermidine; Spermine; Uterus | 1991 |
Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells.
Topics: Animals; Cell Division; Cell Line; Eflornithine; Kinetics; Mice; Polyamines; Spermidine; Spermine Synthase; Structure-Activity Relationship; Substrate Specificity | 1991 |
Polyamine metabolism in Pneumocystis carinii.
Topics: Animals; Arginine; Eflornithine; Lung; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Pentamidine; Pneumocystis; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1991 |
Difluoromethylornithine therapy of female NZB/W mice.
Topics: Animals; Antibodies, Antinuclear; Blood Urea Nitrogen; Eflornithine; Female; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Lupus Vulgaris; Mice; Mice, Inbred BALB C; Proteinuria; Putrescine; Spermidine; Spleen | 1991 |
Role of putrescine in interleukin 1 beta production in human histiocytic lymphoma cell line U937.
Topics: Calcitriol; Cell Differentiation; Cell Division; Eflornithine; Humans; Interleukin-1; Kinetics; Lipopolysaccharides; Lymphoma, Large B-Cell, Diffuse; Monocytes; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Irreversible inhibition of S-adenosylmethionine decarboxylase in Plasmodium falciparum-infected erythrocytes: growth inhibition in vitro.
Topics: Adenosylmethionine Decarboxylase; Animals; Cells, Cultured; Chloroquine; Deoxyadenosines; Eflornithine; Erythrocytes; Humans; Plasmodium falciparum; Polyamines; Spermidine; Spermine | 1991 |
Involvement of polyamines in pancreatic growth induced by dietary soyabean, lectin or trypsin inhibitors.
Topics: Animals; Diet; Eflornithine; Glycine max; Lectins; Ornithine Decarboxylase; Pancreas; Plant Lectins; Polyamines; Rats; Soybean Proteins; Spermidine; Trypsin Inhibitors | 1990 |
The interaction of trypanocidal drugs with polyamine and trypanothione metabolism.
Topics: Animals; Arginine; Carboxy-Lyases; Crithidia; Eflornithine; Glutathione; Ornithine Decarboxylase Inhibitors; Polyamines; Spermidine; Trypanocidal Agents | 1990 |
Feedback regulation of ornithine decarboxylase expression. Studies using a polysomal run-off system.
Topics: Animals; Cell Line; Cell-Free System; Eflornithine; Feedback; Gene Expression Regulation, Enzymologic; Leukemia L1210; Mice; Ornithine Decarboxylase; Polyamines; Polyribosomes; Protein Biosynthesis; RNA, Messenger; Spermidine | 1990 |
Experience affects cortical but not subcortical polyamines.
Topics: Animals; Biogenic Polyamines; Brain; Cerebellum; Cerebral Cortex; Eflornithine; Environment; Male; Medulla Oblongata; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1990 |
Polyamine regulation of the synthesis of thymidine kinase in bovine lymphocytes.
Topics: Adenosylmethionine Decarboxylase; Animals; Base Sequence; Cattle; Cells, Cultured; Concanavalin A; Cycloheximide; DNA Polymerase II; DNA Probes; DNA Replication; Eflornithine; Kinetics; Lymphocyte Activation; Lymphocytes; Mitoguazone; Molecular Sequence Data; Polyamines; Polyribosomes; RNA, Messenger; Spermidine; Thymidine Kinase; Thymidylate Synthase; Transcription, Genetic | 1990 |
Implications for a reduced DNA-elongation rate in polyamine-depleted cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Division; Deoxyribonucleotides; DNA Replication; DNA, Neoplasm; Eflornithine; Kinetics; Mice; Putrescine; Spermidine; Thymidylate Synthase; Tumor Cells, Cultured | 1990 |
Uptake of 3H-labeled 1-aminooxy-3-aminopropane by baby hamster kidney cells.
Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Cricetinae; Eflornithine; Kidney; Ornithine Decarboxylase Inhibitors; Propylamines; Putrescine; Spermidine | 1990 |
Regulation of the Na(+)-dependent and the Na(+)-independent polyamine transporters in renal epithelial cells (LLC-PK1).
Topics: Animals; Biological Transport; Carrier Proteins; Cell Line; Cell Membrane; Cells, Cultured; Chromatography, High Pressure Liquid; Cycloheximide; Dactinomycin; Eflornithine; Epithelial Cells; Epithelium; Kidney; Mitoguazone; Polyamines; Putrescine; Serum Albumin, Bovine; Sodium; Spermidine; Spermine; Swine | 1990 |
Genes responsive to the alteration of polyamine biosynthesis in neurospora crassa.
Topics: Eflornithine; Enzyme Inhibitors; Gene Expression Regulation, Fungal; Neurospora; Neurospora crassa; Ornithine Decarboxylase; Polyamines; Spermidine | 1990 |
Regulation of polyamine biosynthesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Topics: Animals; Ascites; Body Weight; Eflornithine; Female; Liver; Mice; Mice, Inbred Strains; Organ Size; Polyamines; Polychlorinated Dibenzodioxins; Putrescine; Spermidine; Spermine; Spleen; Thymus Gland | 1990 |
A role for polyamines in glucose-stimulated insulin-gene expression.
Topics: Animals; Cell Nucleus; Culture Techniques; Cycloheximide; Dactinomycin; Eflornithine; Gene Expression; Glucose; Insulin; Islets of Langerhans; Male; Mice; Mitoguazone; Polyamines; RNA, Messenger; Spermidine; Spermine | 1990 |
Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Transformation, Neoplastic; Eflornithine; Estradiol; Humans; Insulin-Like Growth Factor I; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1990 |
Polyamine depletion and growth inhibition of Cryptococcus neoformans by alpha-difluoromethylornithine and cyclohexylamine.
Topics: Cryptococcus neoformans; Cyclohexylamines; Dose-Response Relationship, Drug; Eflornithine; Humans; Polyamines; Putrescine; Spermidine; Spermine | 1990 |
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].
Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Carcinoma; Eflornithine; Estrogens; Humans; Male; Mitoguazone; Neoplasm Metastasis; Ornithine; Ornithine Decarboxylase Inhibitors; Prostatic Hyperplasia; Prostatic Neoplasms; Prostatitis; Putrescine; Rats; Spermidine; Spermine | 1985 |
Role of polyamines in experience-dependent brain plasticity.
Topics: Animals; Body Weight; Brain; Cerebral Cortex; DNA; Eflornithine; Male; Neuronal Plasticity; Organ Size; Putrescine; Rats; Rats, Inbred Strains; RNA; Spermidine; Spermine | 1987 |
Pharmacological investigations on the lipolytic and antilipolytic effects of growth hormone (GH) in chicken adipose tissue in vitro: evidence for involvement of calcium and polyamines.
Topics: Adipose Tissue; Animals; Calcimycin; Calcium; Chickens; Chlorpromazine; Cycloheximide; Dactinomycin; Eflornithine; Growth Hormone; Lipolysis; Male; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Synthesis Inhibitors; RNA; Spermidine; Verapamil | 1988 |
Structure and regulation of mammalian S-adenosylmethionine decarboxylase.
Topics: Adenosylmethionine Decarboxylase; Amino Acid Sequence; Animals; Base Sequence; Carboxy-Lyases; Cloning, Molecular; DNA; Eflornithine; Fibroblasts; Humans; Macromolecular Substances; Male; Molecular Sequence Data; Poly A; Rats; RNA; RNA, Messenger; Spermidine | 1988 |
Role of polyamines and intracellular pH change in the hypertrophy of the denervated rat hemidiaphragm.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Denervation; Eflornithine; Hydrogen-Ion Concentration; Hypertrophy; Male; Muscle, Smooth; Polyamines; Putrescine; Rats; Spermidine | 1988 |
Pentagastrin induction of spermine/spermidine N1-acetyltransferase and mucosal polyamines.
Topics: Acetyltransferases; Animals; Chromatography, High Pressure Liquid; Colon; Eflornithine; Enzyme Induction; Gastric Mucosa; Intestinal Mucosa; Kinetics; Male; Parietal Cells, Gastric; Pentagastrin; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine | 1989 |
Production of N1-acetyl spermidine by renal cell tumors.
Topics: Animals; Carcinoma, Renal Cell; Carmustine; Eflornithine; Female; Kidney Neoplasms; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Rats; Spermidine; Tumor Cells, Cultured | 1989 |
Swelling of the Golgi apparatus and decrease of galactosyltransferase in polyamine-deficient bovine lymphocytes and epithelium of mouse small intestine.
Topics: Animals; Cattle; Cells, Cultured; Concanavalin A; Eflornithine; Epithelium; Galactosyltransferases; Golgi Apparatus; Intestinal Mucosa; Intestine, Small; Lymphocyte Activation; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron; Mitoguazone; Polyamines; Spermidine; Spermine | 1989 |
Involvement of antizyme in stabilization of ornithine decarboxylase caused by inhibitors of polyamine synthesis.
Topics: Animals; Cell Line; Cyclohexylamines; Eflornithine; Enzyme Induction; Enzyme Stability; Humans; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Biosynthesis; Proteins; Spermidine | 1989 |
Cellular characterization of a new irreversible inhibitor of S-adenosylmethionine decarboxylase and its use in determining the relative abilities of individual polyamines to sustain growth and viability of L1210 cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Division; Cell Survival; Deoxyadenosines; Eflornithine; Leukemia L1210; Mice; Polyamines; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1989 |
Trypanosoma brucei brucei: regulation of ornithine decarboxylase in procyclic forms and trypomastigotes.
Topics: Animals; Cycloheximide; Dactinomycin; Eflornithine; Enzyme Induction; Half-Life; Male; Ornithine Decarboxylase; Putrescine; Rats; Spermidine; Spermine; Trypanosoma brucei brucei | 1989 |
Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells.
Topics: Actins; Cell Division; Cell Line; Colonic Neoplasms; Eflornithine; Genes; Histones; Humans; Ornithine Decarboxylase; Proto-Oncogenes; Spermidine; Spermine; Transcription, Genetic | 1989 |
Physiological activation of the mitochondrion and the transformation capacity of DFMO induced intermediate and short stumpy bloodstream form trypanosomes.
Topics: Animals; Dihydrolipoamide Dehydrogenase; Eflornithine; Histocytochemistry; Male; Microscopy, Electron; Mitochondria; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Trypanosoma brucei brucei; Trypanosomiasis, African | 1989 |
Characterization of difluoromethylornithine-resistant mouse and human tumour cell lines.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Arginase; Cell Line; Drug Resistance; Eflornithine; Humans; Mice; Ornithine; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Spermidine; Tumor Cells, Cultured | 1989 |
Polyamine-mediated control of mammalian S-adenosyl-L-methionine decarboxylase expression: effects on the content and translational efficiency of the mRNA.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Eflornithine; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Immunosorbent Techniques; Nucleic Acid Hybridization; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Biosynthesis; Putrescine; RNA, Messenger; Spermidine | 1989 |
Polyamine transport systems in the LLC-PK1 renal epithelial established cell line.
Topics: Animals; Biogenic Polyamines; Biological Transport; Cell Differentiation; Cell Division; Cell Line; Eflornithine; Epithelial Cells; Epithelium; Kidney; Putrescine; Sodium; Spermidine; Spermine | 1989 |
Excretion of acetylated and free polyamines by polyamine depleted Chinese hamster ovary cells.
Topics: Animals; Biogenic Polyamines; Cell Division; Cell Line; Eflornithine; Putrescine; Spermidine; Spermine | 1989 |
Paraquat is not accumulated in B16 tumor cells by the polyamine transport system.
Topics: Biological Transport; Dose-Response Relationship, Drug; Eflornithine; Kinetics; Melanoma, Experimental; Paraquat; Polyamines; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1989 |
1,2-Dimethylhydrazine-induced alterations in N1-acetylspermidine levels in rat distal colonic mucosa: effects of 2-difluoromethylornithine.
Topics: 1,2-Dimethylhydrazine; Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Chromatography, High Pressure Liquid; Colon; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Intestinal Mucosa; Male; Methylhydrazines; Ornithine Decarboxylase; Polyamines; Rats; Spermidine | 1989 |
Inhibitory action of alpha-difluoromethylornithine on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat urinary bladder carcinogenesis.
Topics: Animals; Butylhydroxybutylnitrosamine; Drug Administration Schedule; Eflornithine; Male; Neoplasms, Experimental; Putrescine; Rats; Rats, Inbred F344; Spermidine; Spermine; Time Factors; Urinary Bladder Neoplasms | 1989 |
Role of ornithine decarboxylase and polyamines in camostate (Foy-305)-induced pancreatic growth in rats.
Topics: Animals; Cholecystokinin; Eflornithine; Esters; Gabexate; Guanidines; Kinetics; Male; Ornithine Decarboxylase; Pancreas; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1989 |
The essential role of hypusine in eukaryotic translation initiation factor 4D (eIF-4D). Purification of eIF-4D and its precursors and comparison of their activities.
Topics: Animals; Cell Line; Cricetinae; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Isoelectric Point; Lysine; Molecular Weight; Peptide Initiation Factors; Protein Precursors; Protein Processing, Post-Translational; Putrescine; RNA-Binding Proteins; Spermidine; Structure-Activity Relationship | 1989 |
Modulation of growth gene expression by selective alteration of polyamines in human colon carcinoma cells.
Topics: Adenosine; Blotting, Northern; Cell Division; Cell Line; Colonic Neoplasms; Eflornithine; Gene Expression Regulation, Neoplastic; Humans; Polyamines; Proto-Oncogenes; Putrescine; RNA, Messenger; Spermidine; Spermine; Transcription, Genetic; Tumor Cells, Cultured | 1989 |
Inhibition of X-ray-induced DNA strand break repair in polyamine-depleted HeLa cells.
Topics: DNA Repair; DNA, Neoplasm; Eflornithine; HeLa Cells; Humans; Mitoguazone; Polyamines; Putrescine; Spermidine; Spermine | 1989 |
Comparison of the effects of treatment with the polyamine analogue N1,N8 bis(ethyl)spermidine (BESpd) or difluoromethylornithine (DFMO) on the Topoisomerase II mediated formation of 4'-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA) induced cleavabl
Topics: Amsacrine; Chemical Precipitation; DNA Topoisomerases, Type II; DNA, Neoplasm; Eflornithine; Humans; Lung Neoplasms; Polyamines; Spermidine; Tumor Cells, Cultured | 1987 |
Polyamines control human chorionic gonadotropin production in the JEG-3 choriocarcinoma cell.
Topics: Bucladesine; Cell Division; Choriocarcinoma; Chorionic Gonadotropin; Eflornithine; Humans; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; RNA, Messenger; Spermidine; Spermine; Tumor Cells, Cultured | 1988 |
Effects of alpha-difluoromethylornithine on polyamine biosynthesis and tyrosine hydroxylase induction in the adrenal gland of the rat subjected to stress or apomorphine.
Topics: Adrenal Glands; Animals; Apomorphine; Cold Temperature; Eflornithine; Enzyme Induction; Male; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Restraint, Physical; Spermidine; Spermine; Stress, Physiological; Tyrosine 3-Monooxygenase | 1985 |
Evidence against putrescine and polyamines as endogenous mediators of fever.
Topics: Animals; Eflornithine; Endotoxins; Fever; Ornithine; Polyamines; Putrescine; Rabbits; Shigella dysenteriae; Spermidine; Spermine | 1985 |
Covalent incorporation of polyamines as gamma-glutamyl derivatives into CHO cell protein.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cricetulus; Eflornithine; Female; Mitoguazone; Ovary; Polyamines; Proteins; Putrescine; Spermidine; Spermine; Transglutaminases | 1988 |
Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Eflornithine; Erythrocytes; Humans; Liver Neoplasms; Malaria; Mice; Mice, Inbred A; Mice, Inbred Strains; Ornithine; Ornithine Decarboxylase Inhibitors; Plasmodium berghei; Primaquine; Spermidine | 1985 |
Effect of 1,3,6-triaminohexane and 1,4,7-triaminoheptane on growth and polyamine metabolism in SV-3T3 cells treated with 2-difluoromethylornithine.
Topics: Animals; Cell Division; Cell Line; Cell Transformation, Viral; Eflornithine; Fibroblasts; Heptanes; Hexanes; Ornithine; Polyamines; Putrescine; S-Adenosylmethionine; Simian virus 40; Spermidine | 1986 |
Stimulation of polyamine biosynthesis by follicle-stimulating hormone in serum-free cultures of rat Sertoli cells.
Topics: Animals; Bucladesine; Cyclic AMP; Eflornithine; Estradiol; Follicle Stimulating Hormone; Male; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; Sertoli Cells; Spermidine; Spermine | 1987 |
Spermidine mediates degradation of ornithine decarboxylase by a non-lysosomal, ubiquitin-independent mechanism.
Topics: Animals; Cell Line; Eflornithine; Kinetics; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Binding; Spermidine; Temperature; Thermodynamics; Ubiquitins | 1987 |
Cytotoxic response of the relatively difluoromethylornithine-resistant human lung tumor cell line NCI H157 to the polyamine analogue N1,N8-bis(ethyl)spermidine.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Eflornithine; Humans; Lung Neoplasms; Ornithine Decarboxylase Inhibitors; Polyamines; Spermidine | 1987 |
Relationship between ornithine decarboxylase activity and hexamethylene bisacetamide-induced differentiation of murine erythroleukemia cells.
Topics: Acetamides; Animals; Cell Differentiation; Cell Line; Clone Cells; Dexamethasone; Eflornithine; Erythrocytes; Interphase; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Ornithine; Ornithine Decarboxylase; Putrescine; Spermidine; Spermine | 1986 |
Restoration of the polyamine contents in rat hepatoma tissue-culture cells after inhibition of polyamine biosynthesis. Relationship with cell proliferation.
Topics: Alkynes; Animals; Cell Division; Cells, Cultured; Diamines; Eflornithine; Liver Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1986 |
In vivo effects of DL-alpha-difluoromethylornithine on the polyamine and nucleotide phosphate metabolism in P388/S leukemia cells.
Topics: Animals; Cell Line; Eflornithine; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Nucleotides; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine; Time Factors | 1986 |
Selective modulation by alpha-difluoromethylornithine of T-lymphocyte and antibody-mediated cytotoxic responses to mouse tumor allografts.
Topics: Animals; Antibody Formation; Cell Cycle; Cytotoxicity, Immunologic; Eflornithine; Female; Immunization; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Ornithine; Spermidine; Spleen; T-Lymphocytes, Cytotoxic; Time Factors; Transplantation, Homologous | 1986 |
Polyamines in 1 alpha, 25-dihydroxycholecalciferol-induced differentiation of human promyelocytic leukemia cells, HL-60.
Topics: Acetyltransferases; Calcitriol; Cell Differentiation; Cell Division; Cell Line; Eflornithine; Humans; Leukemia, Myeloid; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1986 |
Polyamines and growth regulation of cultured human breast cancer cells by 17 beta-oestradiol.
Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Humans; Insulin; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine; Tamoxifen | 1986 |
Polyamine biosynthesis in trichomonads.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Culture Media; Eflornithine; Eukaryota; Ornithine; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermine; Trichomonas vaginalis; Tritrichomonas | 1986 |
Putrescine does not mediate the androgen-response in mouse kidney.
Topics: Animals; Eflornithine; Female; Kidney; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; RNA, Messenger; Spermidine; Spermine; Testosterone | 1986 |
Effect of putrescine on the respiration of Trypanosoma brucei brucei.
Topics: Animals; Eflornithine; Magnesium; Male; Mitochondria; Ornithine; Oxygen Consumption; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Trypanosoma brucei brucei | 1986 |
Polyamine-mediated turnover of ornithine decarboxylase in Chinese-hamster ovary cells.
Topics: Animals; Cells, Cultured; Chemical Precipitation; Cricetinae; Cricetulus; Eflornithine; Female; Immunoelectrophoresis; Ornithine; Ornithine Decarboxylase; Ovary; Peptide Fragments; Putrescine; Spermidine | 1986 |
A novel mechanism of resistance to alpha-difluoromethylornithine induced by cycloheximide. Growth with abnormally low levels of putrescine and spermidine.
Topics: Animals; Cell Line; Cycloheximide; Drug Resistance; Eflornithine; Fibroblasts; Humans; Mice; Ornithine Decarboxylase; Putrescine; Spermidine | 1986 |
Polyamines and autocrine control of tumor growth by prolactin in experimental breast cancer in culture.
Topics: Animals; Cells, Cultured; Culture Media; Dose-Response Relationship, Drug; Drug Synergism; Eflornithine; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplastic Stem Cells; Polyamines; Prolactin; Rats; Rats, Inbred Strains; Sheep; Spermidine | 1986 |
Comparison and characterization of growth inhibition in L1210 cells by alpha-difluoromethylornithine, an inhibitor of ornithine decarboxylase, and N1,N8-bis(ethyl)spermidine, an apparent regulator of the enzyme.
Topics: Adenosylmethionine Decarboxylase; Alkynes; Animals; Cells, Cultured; Diamines; Eflornithine; Leukemia L1210; Ornithine Decarboxylase Inhibitors; Polyamines; Spermidine | 1986 |
Role of ornithine decarboxylase and polyamines in early postnatal lung growth.
Topics: Animals; Animals, Newborn; DNA; Eflornithine; Lung; Organ Size; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Proteins; Putrescine; Rats; Rats, Inbred Strains; Spermidine | 1986 |
Effects of DL-alpha-difluoromethylornithine on Leishmania donovani promastigotes.
Topics: Animals; Eflornithine; Leishmania donovani; Putrescine; Spermidine; Spermine | 1986 |
Relationship between heat sensitivity and polyamine levels after treatment with alpha-difluoromethylornithine (DFMO).
Topics: Cell Division; Cells, Cultured; Eflornithine; Hot Temperature; Polyamines; Putrescine; Spermidine; Spermine | 1986 |
Accumulation of N1-acetylspermidine in heart and spleen of isoprenaline-treated rats.
Topics: Animals; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Eflornithine; Female; Heart; Isoproterenol; Myocardium; Propranolol; Rats; Rats, Inbred Strains; Spermidine; Spleen | 1986 |
Polyamines and HeLa-cell DNA replication.
Topics: DNA Replication; Eflornithine; HeLa Cells; Humans; Interphase; Polyamines; Putrescine; Spermidine; Spermine; Thymidine | 1986 |
The role of polyamine reutilization in depletion of cellular stores of polyamines in non-proliferating tissues.
Topics: Amino Acids; Animals; Brain; Eflornithine; Kidney; Liver; Male; Mice; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Spermidine | 1987 |
Sensitization of Chinese hamster ovary cells to heat shock by alpha-difluoromethylornithine.
Topics: Animals; Cell Line; Cell Survival; Colony-Forming Units Assay; Cricetinae; Cricetulus; Eflornithine; Female; Hot Temperature; Kinetics; Ovary; Putrescine; Spermidine; Spermine | 1987 |
Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Liver Neoplasms, Experimental; Lysine; Neoplasm Proteins; Peptide Initiation Factors; Protein Binding; Protein Biosynthesis; Rats; RNA-Binding Proteins; Spermidine; Spermine | 1986 |
Transient elevation of intrasynaptosomal free calcium by putrescine.
Topics: Animals; Brain; Calcium; Eflornithine; In Vitro Techniques; Male; Potassium; Putrescine; Rats; Spermidine; Spermine; Synaptosomes | 1987 |
Synergistic inhibition of polyamine synthesis and growth by difluoromethylornithine plus methylthioadenosine in methylthioadenosine phosphorylase-deficient murine lymphoma cells.
Topics: Adenosine; Animals; Cell Division; Cell Line; Deoxyadenosines; Drug Synergism; Eflornithine; Kinetics; Lymphoma; Mice; Pentosyltransferases; Polyamines; Purine-Nucleoside Phosphorylase; Putrescine; Spermidine; Spermine; Thionucleosides | 1987 |
Human myeloma cells acquire resistance to difluoromethylornithine without overproducing ornithine decarboxylase.
Topics: Arginase; Cell Division; Cell Line; Drug Resistance; Eflornithine; Humans; Multiple Myeloma; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine | 1987 |
Effects of progestins on growth of experimental breast cancer in culture: interaction with estradiol and prolactin and involvement of the polyamine pathway.
Topics: Animals; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Drug Synergism; Eflornithine; Estradiol; Mammary Neoplasms, Experimental; Methylnitrosourea; Polyamines; Prolactin; Promegestone; Spermidine | 1987 |
Multiple pathways for uptake of paraquat, methylglyoxal bis(guanylhydrazone), and polyamines.
Topics: Aminoisobutyric Acids; Animals; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Eflornithine; Female; Mitoguazone; Ovary; Paraquat; Polyamines; Putrescine; Spermidine; Spermine | 1987 |
Polyamines and the synthesis of estradiol-regulated growth factors in rat mammary cancer in culture.
Topics: Animals; Cells, Cultured; Culture Media; Eflornithine; Estradiol; Female; Growth Substances; Mammary Neoplasms, Experimental; Polyamines; Rats; Spermidine | 1987 |
Permissive role for ornithine decarboxylase and putrescine in the luteinising hormone surge.
Topics: Animals; Eflornithine; Female; Gonadotropin-Releasing Hormone; In Vitro Techniques; Kinetics; Luteinizing Hormone; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Pituitary Gland, Anterior; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1987 |
Cytostatic effect of DL-alpha-difluoromethylornithine against Plasmodium falciparum and its reversal by diamines and spermidine.
Topics: Animals; Diamines; Dose-Response Relationship, Drug; Eflornithine; Erythrocytes; Glucose; Microscopy, Electron; Ornithine Decarboxylase Inhibitors; Plasmodium falciparum; Polyamines; Spermidine | 1987 |
Regulation of biosynthesis of hypusine in Chinese hamster ovary cells. Evidence for eIF-4D precursor polypeptides.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Cycloheximide; Eflornithine; Female; Fibroblasts; Gene Expression Regulation; Lysine; Ovary; Protein Biosynthesis; Protein Processing, Post-Translational; Spermidine | 1987 |
Enhanced antitumor efficacy with a combination of hyperthermochemotherapy and thermosensitization with polyamine antimetabolites in nude mice.
Topics: Animals; Antimetabolites, Antineoplastic; DNA, Neoplasm; Eflornithine; Hyperthermia, Induced; Mice; Mice, Inbred BALB C; Mice, Nude; Mitoguazone; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Polyamines; Putrescine; Spermidine; Spermine; Stomach Neoplasms; Time Factors | 1987 |
In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei.
Topics: Animals; Chromatography, High Pressure Liquid; Eflornithine; Glutathione; Male; Polyamines; Rats; Rats, Inbred Strains; Spermidine; Sulfhydryl Compounds; Trypanosoma brucei brucei | 1987 |
Changes in the glutathione content of rat 9L cells induced by treatment with the ornithine decarboxylase inhibitor alpha-difluoromethylornithine.
Topics: Alkylating Agents; Animals; Buthionine Sulfoximine; Carmustine; Eflornithine; Glutathione; Methionine Sulfoximine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Spermidine | 1987 |
Polyamines mediate uncontrolled calcium entry and cell damage in rat heart in the calcium paradox.
Topics: Animals; Calcium; Cytosol; Eflornithine; Female; Heart Diseases; Hypothermia, Induced; Microscopy, Electron; Myocardial Contraction; Myocardium; Myoglobin; Ornithine Decarboxylase; Perfusion; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1987 |
Chain-fluorinated polyamines as tumor markers--I. In vivo transformation of 2,2-difluoroputrescine into 6,6-difluorospermidine and 6,6-difluorospermine.
Topics: Animals; Biomarkers, Tumor; Biotransformation; Cattle; Cell Division; Eflornithine; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Polyamines; Putrescine; Rats; Rats, Inbred BUF; Spermidine; Spermine | 1987 |
Mucosal polyamine profile in normal and adapting (hypo and hyperplastic) intestine: effects of DFMO treatment.
Topics: Adaptation, Physiological; Animals; Eflornithine; Hyperplasia; Intestinal Mucosa; Intestine, Small; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1987 |
Role of polyamines in the synthesis of prolactin-regulated growth factors by experimental breast cancer in culture.
Topics: Animals; Colony-Stimulating Factors; Eflornithine; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Prolactin; Rats; Rats, Inbred Strains; Spermidine; Tumor Cells, Cultured | 1987 |
Regulation of ornithine decarboxylase mRNA translation by polyamines. Studies using a cell-free system and a cell line with an amplified ornithine decarboxylase gene.
Topics: Animals; Cell-Free System; Eflornithine; Gene Amplification; Leukemia L1210; Mice; Mutation; Ornithine Decarboxylase; Polyamines; Protein Biosynthesis; Putrescine; Rabbits; Reticulocytes; RNA, Messenger; Spermidine | 1988 |
Effect of polyamine depletion on c-myc expression in human colon carcinoma cells.
Topics: Actins; Cell Cycle; Cell Division; Colonic Neoplasms; Dactinomycin; Eflornithine; Gene Expression Regulation; Half-Life; Histones; Humans; Ornithine Decarboxylase; Polyamines; Proto-Oncogenes; RNA, Messenger; Spermidine; Spermine; Tumor Cells, Cultured | 1988 |
Polyamines and autocrine control of N-nitrosomethylurea-induced rat mammary tumor growth in vitro by progesterone.
Topics: Animals; Cell Division; Concanavalin A; Culture Media; Eflornithine; Mammary Neoplasms, Experimental; Methylnitrosourea; Polyamines; Progesterone; Rats; Spermidine; Steroids; Trypsin; Tumor Stem Cell Assay | 1988 |
Ornithine decarboxylase and polyamine levels in columnar upper gastrointestinal mucosae in patients with Barrett's esophagus.
Topics: Barrett Esophagus; Cell Division; Eflornithine; Epithelial Cells; Epithelium; Esophageal Diseases; Gastric Mucosa; Humans; Intestinal Mucosa; Intestine, Small; Male; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermine | 1988 |
Treatment with polyamine synthesis inhibitors reduces the positive inotropic effect of ouabain, noradrenaline and calcium.
Topics: Animals; Calcium; Cardiotonic Agents; Eflornithine; Heart; Norepinephrine; Ouabain; Polyamines; Putrescine; Pyruvaldehyde; Rats; Spermidine; Spermine | 1988 |
Failure of ornithine decarboxylase inhibition to alter small intestinal epithelial repair after transient segmental ischaemia.
Topics: Animals; Eflornithine; Intestinal Mucosa; Intestine, Small; Ischemia; Ornithine Decarboxylase Inhibitors; Polyamines; Rabbits; Spermidine; Spermine | 1988 |
Renal ornithine decarboxylase activity, polyamines, and compensatory renal hypertrophy in the rat.
Topics: Animals; Eflornithine; Hypertrophy; Kidney; Kinetics; Male; Nephrectomy; Ornithine Decarboxylase; Putrescine; Rats; Rats, Inbred Strains; Reference Values; Spermidine; Spermine | 1988 |
Polyamine depletion and growth inhibition in Candida albicans and Candida tropicalis by alpha-difluoromethylornithine and cyclohexylamine.
Topics: Candida; Candida albicans; Cyclohexylamines; Dose-Response Relationship, Drug; Eflornithine; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermine | 1988 |
Cell-free synthesis of deoxyhypusine. Separation of protein substrate and enzyme and identification of 1,3-diaminopropane as a product of spermidine cleavage.
Topics: Animals; Cell Line; Cell-Free System; Chromatography, Ion Exchange; Cricetinae; Diamines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Lysine; NAD; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine | 1988 |
Role of polyamines in the stimulation of synthesis and secretion of plasminogen activator from bovine aortic endothelial cells.
Topics: Animals; Cattle; Cells, Cultured; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Eflornithine; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Glycoproteins; Mitoguazone; Plasminogen Activators; Plasminogen Inactivators; Polyamines; Putrescine; Spermidine; Spermine | 1988 |
Polyamines are involved in the 1-alpha,25-dihydroxyvitamin D3-induced fusion of mouse alveolar macrophages.
Topics: Animals; Calcitriol; Cell Fusion; Cells, Cultured; Eflornithine; Macrophages; Male; Mice; Mitoguazone; Polyamines; Protein Biosynthesis; Pulmonary Alveoli; Spermidine; Spermine | 1986 |
Studies of non-metabolizable polyamines that support growth of SV-3T3 cells depleted of natural polyamines by exposure to alpha-difluoromethylornithine.
Topics: Acetyltransferases; Animals; Cell Division; Cell Line; Eflornithine; Rats; Spermidine; Spermine; Spermine Synthase; Substrate Specificity | 1988 |
Effect of DL-alpha-difluoromethylornithine on polyamine synthesis and interconversion in Trichomonas vaginalis grown in a semi-defined medium.
Topics: Adenosine; Animals; Cadaverine; Chromatography, High Pressure Liquid; Culture Media; Eflornithine; Ornithine Decarboxylase; Polarography; Polyamines; Putrescine; S-Adenosylmethionine; Spermidine; Spermine; Trichomonas vaginalis | 1988 |
Modification of uptake and antiproliferative effect of methylglyoxal bis(guanylhydrazone) by treatment with alpha-difluoromethylornithine in rodent cell lines with different sensitivities to methylglyoxal bis(guanylhydrazone).
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Eflornithine; Guanidines; Kinetics; Mitochondria; Mitoguazone; Ornithine; Putrescine; Pyruvates; Pyruvic Acid; Rats; Spermidine; Temperature; Time Factors | 1985 |
Inhibition of carcinogenesis by alpha-difluoromethylornithine in heterotopically transplanted rat urinary bladders.
Topics: Animals; Eflornithine; Male; Methylnitrosourea; Ornithine; Putrescine; Rats; Rats, Inbred F344; Spermidine; Spermine; Urinary Bladder; Urinary Bladder Neoplasms | 1985 |
Requirement of spermidine for induction of both heme synthesis and globin transcription in murine erythroleukemia cells.
Topics: Animals; Cell Division; Dexamethasone; Dimethyl Sulfoxide; Eflornithine; Globins; Heme; Leukemia, Erythroblastic, Acute; Mice; Ornithine; Spermidine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1985 |
Biological properties of N4- and N1,N8-spermidine derivatives in cultured L1210 leukemia cells.
Topics: Animals; Cells, Cultured; Eflornithine; Kinetics; Leukemia L1210; Mice; Ornithine; Polyamines; Spermidine; Structure-Activity Relationship | 1985 |
Polyamine reutilization and turnover in brain.
Topics: Alkynes; Aminocaproates; Animals; Brain; Brain Chemistry; Eflornithine; Male; Mice; Ornithine; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Spermidine; Spermine; Vigabatrin | 1985 |
Ornithine decarboxylase modification and polyamine-stimulated enzyme inactivation in HTC cells.
Topics: Animals; Cell Line; Chromatography, Gel; Chromatography, Ion Exchange; Cycloheximide; Eflornithine; Isoenzymes; Mitoguazone; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Spermidine | 1985 |
Regulation of S-adenosylmethionine decarboxylase activity in rat liver and prostate.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cycloheximide; Eflornithine; Half-Life; Immunosorbent Techniques; Kinetics; Liver; Male; Mitoguazone; Molecular Weight; Ornithine; Prostate; Putrescine; Rabbits; Radioimmunoassay; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1985 |
Ornithine decarboxylase of Plasmodium falciparum: a peak-function enzyme and its inhibition by chloroquine.
Topics: Animals; Chloroquine; Drug Interactions; Eflornithine; Hydrogen-Ion Concentration; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plasmodium falciparum; Putrescine; Spermidine | 1985 |
Effects of difluoromethylornithine on proliferation, polyamine content and plating efficiency of cultured human carcinoma cells.
Topics: Cell Division; Cell Line; Clone Cells; Eflornithine; Female; Humans; Kinetics; Neoplasms; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1985 |
Methylglyoxal BIS (guanylhydrazone) and alpha-difluoromethylornithine-induced polyamine deprivation in psoriatic lesions.
Topics: Carboxy-Lyases; Dose-Response Relationship, Drug; Eflornithine; Guanidines; Humans; Injections, Intradermal; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Psoriasis; Putrescine; Skin; Spermidine; Spermine | 1982 |
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.
Topics: Animals; Bleomycin; Central Nervous System Diseases; Disease Models, Animal; Drug Therapy, Combination; Eflornithine; Female; Male; Mice; Ornithine; Spermidine; Spermine; Trypanocidal Agents; Trypanosomiasis, African | 1983 |
Effect of polyamine antimetabolites on cultured human keratinocytes from normal and uninvolved psoriatic skin.
Topics: Antimetabolites; Cell Division; Cells, Cultured; DNA; Eflornithine; Guanidines; Humans; Keratins; Mitoguazone; Ornithine; Protein Biosynthesis; Psoriasis; Putrescine; Skin; Spermidine; Spermine | 1984 |
Temperature-dependent and transformation-associated changes in polyamine metabolism in normal and Rous sarcoma virus-infected chick embryo fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Chick Embryo; Eflornithine; Fibroblasts; Ornithine; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermidine; Spermine; Temperature | 1981 |
Role of polyamines in the proliferation and steroidogenic activities of bovine adrenocortical cells in culture.
Topics: Adrenal Cortex; Animals; Carboxy-Lyases; Cattle; Cell Division; Cells, Cultured; Cosyntropin; Cyclic AMP; Eflornithine; Hydrocortisone; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine | 1981 |
Inhibitors of polyamine biosynthesis block human cytomegalovirus replication.
Topics: Antiviral Agents; Cells, Cultured; Cytomegalovirus; Eflornithine; Guanidines; Humans; Mitoguazone; Ornithine; Polyamines; Spermidine; Spermine; Virus Replication | 1982 |
Growth regulatory effects of cyclic AMP and polyamine depletion are dissociable in cultured mouse lymphoma cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Bucladesine; Cell Division; Cell Line; Cyclic AMP; Eflornithine; Interphase; Lymphoma; Mice; Models, Biological; Ornithine; Ornithine Decarboxylase; Polyamines; Protein Kinases; Putrescine; Spermidine | 1983 |
D,L-alpha-difluoromethylornithine inhibits human cytomegalovirus replication.
Topics: Cells, Cultured; Cytomegalovirus; DNA, Viral; Eflornithine; Humans; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Simplexvirus; Spermidine; Spermine; Viral Proteins; Virion; Virus Replication | 1984 |
Radiochemical determination of polyamines in poliovirus and human rhinovirus 14.
Topics: Eflornithine; HeLa Cells; Humans; Kinetics; Ornithine; Ornithine Decarboxylase Inhibitors; Poliovirus; Putrescine; Rhinovirus; Spermidine; Spermine | 1984 |
Inhibition of growth of Giardia lamblia by difluoromethylornithine, a specific inhibitor of polyamine biosynthesis.
Topics: Animals; Eflornithine; Entamoeba histolytica; Giardia; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Trichomonas vaginalis | 1984 |
Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; DNA, Neoplasm; Eflornithine; Molecular Conformation; Ornithine; Polyamines; Putrescine; Rats; Spermidine; Viscosity | 1983 |
Effects of alpha-difluoromethylornithine and 5-fluorouracil on the proliferation of a human colon adenocarcinoma cell line.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Cycle; Cell Line; Cell Survival; Eflornithine; Fluorouracil; Humans; Kinetics; Ornithine; Putrescine; Spermidine | 1983 |
Inhibition of DNA and protein synthesis in UV-irradiated mouse skin by 2-difluoromethylornithine, methylglyoxal bis(guanylhydrazone), and their combination.
Topics: Animals; DNA Replication; Drug Interactions; Eflornithine; Female; Guanidines; Mice; Mitoguazone; Ornithine; Protein Biosynthesis; Putrescine; Skin; Spermidine; Ultraviolet Rays | 1983 |
Inhibition of ornithine decarboxylase induces embryonal carcinoma cell differentiation.
Topics: Animals; Carboxy-Lyases; Cell Differentiation; Cell Line; Eflornithine; Mice; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine; Teratoma | 1983 |
Determination of free and total polyamines in human serum and urine by ion-pairing high-performance liquid chromatography using a radial compression module. Application to blood polyamine determination in cancer patients treated or not treated with an orn
Topics: Aged; Cadaverine; Chromatography, High Pressure Liquid; Eflornithine; Female; Fluorescence; Humans; Male; Middle Aged; Neoplasms; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1983 |
Differential effect of alpha-difluoromethylornithine on the in vivo uptake of 14C-labeled polyamines and methylglyoxal bis(guanylhydrazone) by a rat prostate-derived tumor.
Topics: Animals; Antineoplastic Agents; Biological Transport; Carbon Radioisotopes; Cells, Cultured; Eflornithine; Guanidines; Male; Mitoguazone; Ornithine; Polyamines; Prostatic Neoplasms; Putrescine; Rats; Rats, Inbred Strains; Spermidine | 1984 |
Role of polyamines in differentiation of 3T3-L1 fibroblasts into adipocytes.
Topics: Adipose Tissue; Animals; Cell Differentiation; Cells, Cultured; Eflornithine; Fibroblasts; Mice; Ornithine; Polyamines; Putrescine; Spermidine; Spermine | 1984 |
Effects of polyamine depletion on proliferation and differentiation of murine erythroleukemia cells.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Diazepam; Dimethyl Sulfoxide; Eflornithine; Kinetics; Leukemia, Experimental; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1984 |
Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells.
Topics: Animals; Cell Division; Cells, Cultured; Centrifugation, Density Gradient; Cycloheximide; Eflornithine; Liver Neoplasms, Experimental; Macromolecular Substances; Neoplasm Proteins; Ornithine; Polyribosomes; Putrescine; Rats; Spermidine; Spermine | 1984 |
Involvement of spermidine in proliferation and differentiation of human promyelocytic leukemia cells.
Topics: Acetamides; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Humans; Leukemia, Myeloid, Acute; Ornithine; Putrescine; Spermidine; Spermine | 1984 |
Time dependence of the potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity caused by alpha-difluoromethylornithine-induced polyamine depletion in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Line; Drug Synergism; Eflornithine; Kinetics; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Spermidine | 1984 |
Enhancement of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced cytotoxicity and DNA damage by alpha-difluoromethylornithine in L1210 leukemia cells.
Topics: Animals; Carmustine; Cell Survival; DNA, Neoplasm; Drug Synergism; Eflornithine; Kinetics; Leukemia L1210; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1984 |
Polyamines as mediators of estrogen action on the growth of experimental breast cancer in rats.
Topics: Animals; Cell Aggregation; Eflornithine; Estradiol; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1984 |
Different efflux rates may determine the cellular accumulation of various bis(guanylhydrazones).
Topics: Animals; Cells, Cultured; Eflornithine; Guanidines; Leukemia L1210; Mice; Mitoguazone; Ornithine; Spermidine; Time Factors | 1984 |
Polyamine requirements for induction of HL-60 promyelocyte differentiation by leukocyte-conditioned medium and phorbol ester.
Topics: Antibodies, Monoclonal; Cell Differentiation; Cell Line; Culture Media; Eflornithine; Humans; Kinetics; Leukemia, Myeloid, Acute; Leukocytes; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Spermidine; Tetradecanoylphorbol Acetate | 1984 |
Polyamine biosynthetic enzymes as targets in cancer chemotherapy.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Enzyme Inhibitors; Methionine; Mice; Ornithine; Putrescine; Spermidine; Spermine; Teratoma | 1984 |
Polyamines in brain and heart of the neonatal rat: effects of inhibitors of ornithine decarboxylase and spermidine synthase.
Topics: Animals; Animals, Newborn; Brain; Cyclohexylamines; Dose-Response Relationship, Drug; Eflornithine; Female; Heart; Male; Myocardium; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Pregnancy; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermidine Synthase; Spermine; Transferases | 1984 |
Physiological effects in bovine lymphocytes of inhibiting polyamine synthesis with ethylglyoxal bis(guanylhydrazone).
Topics: Animals; Aphidicolin; Cattle; Cycloheximide; Diterpenes; DNA Replication; Eflornithine; Guanidines; Kinetics; Lymphocytes; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Biosynthesis; Proteins; Spermidine | 1984 |
Polyamines and the development of monocrotaline-induced pulmonary hypertension.
Topics: Adenosylmethionine Decarboxylase; Animals; Blood Pressure; Eflornithine; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy; Kinetics; Lung; Male; Monocrotaline; Ornithine; Ornithine Decarboxylase Inhibitors; Plants, Toxic; Polyamines; Putrescine; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio; Spermidine; Spermine | 1984 |
Treatment with alpha-difluoromethylornithine plus a spermidine analog leads to spermine depletion and growth inhibition in cultured L1210 leukemia cells.
Topics: Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Eflornithine; Leukemia L1210; Mice; Ornithine; Spermidine; Spermine | 1984 |
The role of polyamine depletion and accumulation of decarboxylated S-adenosylmethionine in the inhibition of growth of SV-3T3 cells treated with alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Cells, Cultured; Diamines; Eflornithine; Fibroblasts; Mice; Mice, Inbred Strains; Ornithine; Polyamines; S-Adenosylmethionine; Spermidine | 1984 |
Polyamines and pancreatic growth induced by caerulein.
Topics: Animals; Ceruletide; DNA; Eflornithine; Male; Organ Size; Ornithine; Pancreas; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1984 |
Irreversible inhibition of the early increase in ornithine decarboxylase activity following growth stimulation is required to block Ehrlich ascites tumor cell proliferation in culture.
Topics: Animals; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Cell Division; Eflornithine; Kinetics; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine | 1980 |
Polyamine depletion induces enhanced synthesis and accumulation of cadaverine in cultured Ehrlich ascites carcinoma cells.
Topics: Animals; Cadaverine; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Cells, Cultured; Diamines; Eflornithine; Female; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine | 1980 |
Depletion of intracellular polyamine content does not alter the survival of 9L rat brain tumour cells after X-irradiation.
Topics: Animals; Brain Neoplasms; Cell Line; Cell Survival; Cells, Cultured; DNA; DNA, Neoplasm; Eflornithine; Guanidines; Mitoguazone; Ornithine; Polyamines; Putrescine; Radiation Tolerance; Rats; Spermidine; Spermine; X-Rays | 1980 |
Depletion of 9L rat brain tumor cell polyamine content by treatment with D,L-alpha-difluoromethylornithine inhibits proliferation and the G1 to S transition.
Topics: Animals; Brain Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Eflornithine; Interphase; Ornithine; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1981 |
Ovarian function in the rat following irreversible inhibition of L-ornithine decarboxylase.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Estrus; Female; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Ovary; Ovulation; Pregnancy; Putrescine; Rats; Spermidine; Spermine | 1980 |
Intracellular putrescine and spermidine deprivation induces increased uptake of the natural polyamines and methylglyoxal bis(guanylhydrazone).
Topics: Adenosylmethionine Decarboxylase; Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Eflornithine; Guanidines; Mitoguazone; Ornithine; Ornithine Decarboxylase; Putrescine; Spermidine | 1980 |
Selective killing of transformed cells in combination with inhibitors of polyamine biosynthesis and S-phase specific drugs.
Topics: Cell Division; Cell Transformation, Neoplastic; Cytarabine; Drug Synergism; Eflornithine; HeLa Cells; Humans; Interphase; Ornithine; Polyamines; Spermidine; Spermine | 1981 |
Polyamines are needed for the differentiation of 3T3-L1 fibroblasts into adipose cells.
Topics: Adipose Tissue; Animals; Cell Differentiation; Cells, Cultured; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine | 1981 |
Indirect evidence for a strict negative control of S-adenosyl-L-methionine decarboxylase by spermidine in rat hepatoma cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Division; Cell Line; Eflornithine; Liver Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Spermidine | 1981 |
Formation and interconversion of putrescine and spermidine in mammalian cells.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Cell Line; Eflornithine; Enzyme Activation; Enzyme Repression; Liver; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine | 1980 |
Effects of inhibitors of ornithine and S-adenosylmethionine decarboxylases on L6 myoblast proliferation.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Cells, Cultured; Eflornithine; Mitoguazone; Muscles; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1982 |
Effect of epidermal polyamine depletion on the accumulation of methylglyoxal bis(guanylhydrazone) in mouse skin.
Topics: Animals; Eflornithine; Female; Guanidines; Mice; Mitoguazone; Ornithine; Polyamines; Putrescine; Skin; Skin Physiological Phenomena; Spermidine | 1982 |
Some properties of the polyamine deprivation-inducible uptake system for methylglyoxal bis(guanylhydrazone) in tumor cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Eflornithine; Guanidines; Iodoacetates; Iodoacetic Acid; Mice; Mitoguazone; Neoplasms, Experimental; Ornithine; Ouabain; Polyamines; Putrescine; Spermidine | 1981 |
Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Drug Antagonism; Eflornithine; Kinetics; Mice; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Putrescine; Skin; Skin Neoplasms; Spermidine; Spermine; Tetradecanoylphorbol Acetate | 1982 |
Ornithine decarboxylase and polyamines in tissues of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Animals, Newborn; Brain; Carboxy-Lyases; Eflornithine; Female; Heart; Kidney; Myocardium; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Pregnancy; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1982 |
Polyamine depletion influences drug-induced chromosomal damage.
Topics: Animals; Carmustine; Chromosomes; Cisplatin; DNA; Eflornithine; Nucleic Acid Conformation; Ornithine; Polyamines; Putrescine; Rats; Sister Chromatid Exchange; Spermidine; Spermine | 1982 |
Combined topical use of difluoromethyl ornithine and methylglyoxal bis (guanylhydrazone) in UV-irradiated mouse skin.
Topics: Adenosylmethionine Decarboxylase; Animals; Eflornithine; Female; Guanidines; Male; Mice; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Skin; Spermidine; Ultraviolet Rays | 1982 |
Polyamine cytochemistry. Use of a novel o-phtalaldehyde method for visualizing spermidine and spermine. Comparisons to the formaldehyde-fluorescamine method.
Topics: Aldehydes; Animals; Cats; Eflornithine; Fluorescamine; Formaldehyde; Histocytochemistry; Hydrogen-Ion Concentration; Methods; o-Phthalaldehyde; Ornithine; Polyamines; Rats; Spermidine; Spermine; Spiro Compounds | 1982 |
Structural requirements of analogues of polyamines for migration and growth of IEC-6 cells.
Topics: Animals; Biogenic Polyamines; Cell Division; Cell Migration Inhibition; Cell Movement; Cells, Cultured; Eflornithine; Intestines; Spermidine; Spermine; Structure-Activity Relationship | 1995 |
Polyamines inhibit nitric oxide synthase in rat cerebellum.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cells, Cultured; Cerebellum; Citrulline; Cytosol; Eflornithine; Kinetics; N-Methylaspartate; Neurons; Nitric Oxide Synthase; omega-N-Methylarginine; Polyamines; Putrescine; Rats; Spermidine; Spermine; Tritium | 1994 |
Polyamine depletion-mediated effects on murine odontogenesis are dependent on tooth developmental stage and culture conditions.
Topics: Animals; Cell Differentiation; Cell Division; Culture Media; DNA; Eflornithine; Guanidines; Mice; Mitoguazone; Odontoblasts; Odontogenesis; Organ Culture Techniques; Polyamines; Putrescine; Spermidine; Time Factors; Tooth | 1995 |
Depletion of cellular polyamines by alpha-difluoromethylornithine increases 1,3-bis(2-chloroethyl)-1-nitrosourea-induced sister-chromatid exchanges.
Topics: Animals; Carmustine; Cell Survival; Cells, Cultured; Eflornithine; Nucleic Acid Conformation; Polyamines; Putrescine; Rats; Sister Chromatid Exchange; Spermidine | 1993 |
Polyamines and prostatic carcinoma: clinical and therapeutic implications.
Topics: Adult; Aged; Animals; Biomarkers, Tumor; Cell Division; Cell Transformation, Neoplastic; Eflornithine; Erythrocyte Count; Erythrocytes; Follow-Up Studies; Humans; Male; Mice; Middle Aged; Models, Biological; Neoplasm Staging; Prognosis; Prostate-Specific Antigen; Prostatic Neoplasms; Spermidine; Spermine | 1993 |
Studies on the mechanism by which prolactin stimulates alpha-aminoisobutyric acid uptake into cultured mouse mammary tissues.
Topics: 1-Methyl-3-isobutylxanthine; Aminoisobutyric Acids; Animals; Biogenic Polyamines; Bucladesine; Cells, Cultured; Eflornithine; Enzyme Activation; Female; Indomethacin; Mammary Glands, Animal; Mice; Mitoguazone; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Prolactin; Prostaglandins; Protein Kinase C; Spermidine | 1993 |
Polyamine metabolism in human hepatocellular cancer cells (Hep-G2).
Topics: Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; DNA, Neoplasm; Eflornithine; Humans; Liver Neoplasms; Polyamines; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1994 |
Hormonal and feedback regulation of putrescine and spermidine transport in human breast cancer cells.
Topics: Biological Transport; Breast Neoplasms; Cell Division; Cell Line; Cycloheximide; Drug Synergism; Eflornithine; Estradiol; Feedback; Humans; Insulin; Kinetics; Putrescine; Spermidine; Spermine; Tretinoin; Tumor Cells, Cultured | 1995 |
Aminooxy analogues of spermidine evidence the divergent roles of the charged amino nitrogens in the cellular physiology of spermidine.
Topics: Animals; Biogenic Polyamines; Biological Transport; Cell Division; Cells, Cultured; Cricetinae; Eflornithine; Embryo, Mammalian; Kidney; Polyamines; Putrescine; S-Adenosylmethionine; Spermidine; Structure-Activity Relationship | 1995 |
Effects of metal treatment on DNA repair in polyamine-depleted HeLa cells with special reference to nickel.
Topics: DNA Repair; Eflornithine; HeLa Cells; Humans; Metals; Nickel; Putrescine; Spermidine; Spermine | 1994 |
Induction of low-affinity GABAA receptors by the GABA-agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) in cultured rat cerebellar granule cells is prevented by inhibition of polyamine biosynthesis.
Topics: Animals; Biogenic Polyamines; Cells, Cultured; Cerebellum; Eflornithine; GABA Agonists; Isoxazoles; Kinetics; Membranes; Neurons; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Wistar; Receptors, GABA-A; Spermidine | 1994 |
Regulation of N-methyl-D-aspartate receptor-mediated calcium transport and norepinephrine release in rat hippocampus synaptosomes by polyamines.
Topics: 2-Amino-5-phosphonovalerate; Animals; Biological Transport; Calcium; Eflornithine; Egtazic Acid; Female; Hippocampus; Kinetics; N-Methylaspartate; Norepinephrine; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Synaptosomes | 1994 |
Regulation of transglutaminase activity by polyamines in the gastrointestinal mucosa of rats.
Topics: Animals; Chromatography, High Pressure Liquid; Duodenum; Eflornithine; Gastric Mucosa; Intestinal Mucosa; Kinetics; Male; Ornithine Decarboxylase; Parietal Cells, Gastric; Polyamines; Putrescine; Rats; Rats, Sprague-Dawley; Spermidine; Spermine; Time Factors; Transglutaminases | 1994 |
Polyamines influence transglutaminase activity and cell migration in two cell lines.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Line; Cell Movement; Eflornithine; Humans; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermidine; Transglutaminases | 1994 |
Effects of the S-adenosylmethionine decarboxylase inhibitor, 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine, on cell growth and polyamine metabolism and transport in Chinese hamster ovary cell cultures.
Topics: Adenosylmethionine Decarboxylase; Animals; Biological Transport; Cell Division; CHO Cells; Cricetinae; Cycloheximide; Deoxyadenosines; Eflornithine; Kinetics; Polyamines; Putrescine; Spermidine; Spermine | 1994 |
Polyamines regulate human medullary thyroid carcinoma TT-cell proliferation and secretion of calcitonin and calcitonin gene-related peptide.
Topics: Adenosylmethionine Decarboxylase; Calcitonin; Calcitonin Gene-Related Peptide; Carcinoma, Medullary; Cell Division; Eflornithine; Humans; Mitoguazone; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine; Thyroid Neoplasms; Tumor Cells, Cultured | 1994 |
Polyamine regulation of atrial natriuretic peptide in cultured cardiocytes.
Topics: Animals; Atrial Natriuretic Factor; Cells, Cultured; Eflornithine; L-Lactate Dehydrogenase; Leucine; Myocardium; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Biosynthesis; Putrescine; Rats; Spermidine | 1994 |
The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Deoxyadenosines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Leukemia L1210; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine; Spermine; Substrate Specificity; Tumor Cells, Cultured | 1994 |
Postnatal development of ornithine decarboxylase and polyamines in the mouse kidney: influence of testosterone.
Topics: Animals; Eflornithine; Female; Flutamide; Kidney; Male; Mice; Organ Size; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Sex Characteristics; Spermidine; Testosterone | 1994 |
Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications.
Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Female; Flow Cytometry; G1 Phase; Gene Expression; Humans; Kinetics; Ornithine Decarboxylase; Polyamines; Putrescine; RNA, Messenger; Spermidine; Spermine; Structure-Activity Relationship; Thymidine; Time Factors; Tumor Cells, Cultured | 1994 |
Polyamine content and drug sensitivities of different clonal lines of Leishmania infantum promastigotes.
Topics: Animals; Diminazene; Drug Resistance; Eflornithine; Leishmania infantum; Polyamines; Putrescine; Spermidine | 1994 |
Involvement of polyamines in epidermal growth factor (EGF), transforming growth factor (TGF)-alpha and -beta 1 action on culture of L6 and fetal bovine myoblasts.
Topics: Adenosylmethionine Decarboxylase; Animals; Cattle; Cell Line; Cells, Cultured; Eflornithine; Epidermal Growth Factor; Humans; Muscles; Ornithine Decarboxylase; Polyamines; Protein Biosynthesis; Rats; Signal Transduction; Spermidine; Spermine; Transforming Growth Factor alpha; Transforming Growth Factor beta | 1994 |
Characterization of polyamine transport in rat aortic smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Biological Transport; Carbon Radioisotopes; Cells, Cultured; Eflornithine; Kinetics; Muscle, Smooth, Vascular; Paraquat; Polyamines; Putrescine; Rats; Rats, Sprague-Dawley; Spermidine; Spermine | 1994 |
Induction of ornithine decarboxylase by N-methyl-D-aspartate receptor activation is unrelated to potentiation of glutamate excitotoxicity by polyamines in cerebellar granule neurons.
Topics: Animals; Cell Death; Cells, Cultured; Cerebellum; Drug Synergism; Eflornithine; Enzyme Induction; Glutamates; Glutamic Acid; Neurons; Ornithine Decarboxylase; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spermidine; Spermine | 1993 |
Ornithine decarboxylase inhibition or NMDA receptor antagonism reduce cortical polyamine efflux associated with dialysis probe implantation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Biogenic Polyamines; Cerebral Cortex; Chromatography, High Pressure Liquid; Dialysis; Eflornithine; Male; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine | 1993 |
[The effect of chemically modified polyamine analogs on polyamine and putrescine biosynthesis in a cell-free test system from a rat hepatoma].
Topics: Animals; Antineoplastic Agents; Biogenic Polyamines; Cell-Free System; Eflornithine; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermidine; Spermine; Structure-Activity Relationship | 1993 |
Increased spermidine or spermine level is essential for hepatocyte growth factor-induced DNA synthesis in cultured rat hepatocytes.
Topics: Adenosylmethionine Decarboxylase; Animals; Cells, Cultured; DNA; Eflornithine; Hepatocyte Growth Factor; Liver; Male; Mitoguazone; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Rats; Rats, Wistar; Spermidine; Spermine | 1994 |
Postnatal changes in cochlear polyamine metabolism in the rat.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cochlea; Eflornithine; Female; Organ of Corti; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Pregnancy; Putrescine; Rats; Spermidine; Spermine | 1994 |
Expression of protooncogenes c-fos and c-myc in healing of gastric mucosal stress ulcers.
Topics: Animals; Blotting, Northern; Blotting, Western; DNA; DNA Probes; Eflornithine; Enzyme Induction; Gastric Mucosa; Gene Expression; Genes, fos; Genes, myc; Immersion; Kinetics; Male; Ornithine Decarboxylase; Parietal Cells, Gastric; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Putrescine; Rats; Rats, Sprague-Dawley; Restraint, Physical; RNA, Messenger; Spermidine; Spermine; Stomach Ulcer; Stress, Psychological; Thymidine; Time Factors; Wound Healing | 1994 |
Selenium and difluoromethylornithine additively inhibit DMH-induced distal colon tumor formation in rats fed a fiber-free diet.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Diet; Dietary Fiber; Dimethylhydrazines; Drug Interactions; Eflornithine; Liver; Male; Ornithine Decarboxylase; Putrescine; Rats; Rats, Sprague-Dawley; Reference Values; S-Adenosylmethionine; Selenium; Spermidine; Spermine | 1993 |
Radiosensitivity of polyamine-depleted HeLa cells and modulation by the aminothiol WR-1065.
Topics: Cell Survival; Clone Cells; Deoxyadenosines; DNA Damage; Dose-Response Relationship, Radiation; Eflornithine; HeLa Cells; Humans; Kinetics; Mercaptoethylamines; Mitoguazone; Polyamines; Putrescine; Radiation-Protective Agents; Spermidine; Spermine; Time Factors; Tumor Stem Cell Assay; X-Rays | 1994 |
TGF-beta 1 inhibits polyamine biosynthesis in K 562 leukemic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosylmethionine Decarboxylase; Apoptosis; Cell Division; Cell Line; Dose-Response Relationship, Drug; Eflornithine; Humans; Isoquinolines; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitoguazone; Ornithine Decarboxylase; Piperazines; Polyamines; Protein Kinase Inhibitors; Putrescine; Spermidine; Spermine; Transforming Growth Factor beta; Tumor Cells, Cultured | 1993 |
Cellular pharmacology of N1- and N8-aziridinyl analogues of spermidine.
Topics: Alkylating Agents; Animals; Aziridines; Eflornithine; Leukemia L1210; Mice; Polyamines; Spermidine; Time Factors; Tumor Cells, Cultured | 1994 |
Feedback regulation of mammalian ornithine decarboxylase. Studies using a transient expression system.
Topics: Animals; Cell Line; DNA; Eflornithine; Feedback; Gene Expression Regulation, Enzymologic; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Processing, Post-Translational; Spermidine | 1993 |
Decreased expression of protooncogenes c-fos, c-myc, and c-jun following polyamine depletion in IEC-6 cells.
Topics: Animals; Cell Division; Cell Line; Eflornithine; Gene Expression; Intestine, Small; Polyamines; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; Spermidine | 1993 |
Stress induction of the spermidine/spermine N1-acetyltransferase by a post-transcriptional mechanism in mammalian cells.
Topics: Acetylation; Acetyltransferases; Animals; CHO Cells; Cricetinae; Ditiocarb; Eflornithine; Enzyme Induction; Hot Temperature; Humans; Lung Neoplasms; Melanoma; RNA, Messenger; Spermidine; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Neoplasm; Eflornithine; Glucose; Glyburide; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Polyamines; Potassium; Putrescine; Rats; RNA, Messenger; Spermidine; Spermine; Tetradecanoylphorbol Acetate; Theophylline; Tolbutamide; Tumor Cells, Cultured | 1993 |
Role of polyamine biosynthesis during gut mucosal adaptation after burn injury.
Topics: Adaptation, Physiological; Animals; Burns; Eflornithine; Intestinal Mucosa; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Rats, Sprague-Dawley; Spermidine | 1993 |
Polyamines and intestinal epithelial hyperplasia in streptozotocin-diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Eflornithine; Epithelium; Hyperplasia; Intestinal Mucosa; Jejunum; Male; Organ Size; Ornithine Decarboxylase; Putrescine; Rats; Rats, Sprague-Dawley; Reference Values; Spermidine; Sucrase; Thymidine Kinase | 1993 |
Chemoprevention of oral carcinogenesis by DL-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor: dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neoplasms in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Eflornithine; Hyperplasia; Male; Papilloma; Precancerous Conditions; Rats; Rats, Inbred ACI; Spermidine; Spermine; Tongue; Tongue Neoplasms | 1993 |
Polyamines are necessary for cell migration by a small intestinal crypt cell line.
Topics: Animals; Cell Line; Cell Movement; Eflornithine; Intestine, Small; Intracellular Membranes; Polyamines; Putrescine; Spermidine; Spermine | 1993 |
Effects of polyamine biosynthesis inhibitors on the progesterone-initiated increase in intracellular free Ca2+ and acrosome reactions in human sperm.
Topics: Acrosome; Adenosylmethionine Decarboxylase; Calcium; Deoxyadenosines; Eflornithine; Humans; In Vitro Techniques; Male; Polyamines; Progesterone; Putrescine; Spermatozoa; Spermidine | 1993 |
Regulation of spermidine/spermine N1-acetyltransferase by intracellular polyamine pools. Evidence for a functional role in polyamine homeostasis.
Topics: Acetyltransferases; Blotting, Northern; Eflornithine; Gene Expression Regulation, Enzymologic; Homeostasis; Humans; Melanoma; Models, Biological; Polyamines; Putrescine; RNA, Messenger; Spermidine; Spermine; Tumor Cells, Cultured | 1993 |
Antileukemic effects of non-metabolizable derivatives of spermidine and spermine.
Topics: Adenosylmethionine Decarboxylase; Animals; Drug Synergism; Eflornithine; Female; Leukemia L1210; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Ornithine Decarboxylase; Spermidine; Spermine | 1993 |
Spermidine-induced destabilization of ornithine decarboxylase (ODC) is mediated by accumulation of antizyme in ODC-overproducing variant cells.
Topics: Animals; Antibodies; Cell Line; Cell-Free System; Clone Cells; Cysteine; Eflornithine; Enzyme Induction; Kinetics; Methionine; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Proteins; Spermidine; Sulfur Radioisotopes | 1993 |
Spermine action on mitochondrial H(+)-ATPase activity and proliferation rate of Trypanosoma cruzi.
Topics: Animals; Cycloheximide; Eflornithine; Kinetics; Mitochondria; Proton-Translocating ATPases; Putrescine; Spermidine; Spermine; Submitochondrial Particles; Trypanosoma cruzi | 1995 |
Stable intracellular acidification upon polyamine depletion induced by alpha-difluoromethylornithine or N1,N12-bis(ethyl)spermine in L1210 leukaemia cells.
Topics: Animals; Antineoplastic Agents; Bicarbonates; Eflornithine; Hydrogen-Ion Concentration; Leukemia L1210; Mice; Nigericin; Polyamines; Putrescine; Sodium-Hydrogen Exchangers; Spermidine; Spermine | 1995 |
Inhibition of polyamine synthesis alters hair follicle function and fiber composition.
Topics: Adenosylmethionine Decarboxylase; Animals; Culture Media; Eflornithine; Enzyme Inhibitors; Gene Expression; Hair; Hair Follicle; Keratins; Mitoguazone; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Sheep; Spermidine; Spermine | 1996 |
Regulation by spermine of native inward rectifier K+ channels in RBL-1 cells.
Topics: Animals; Deoxyadenosines; Eflornithine; Leukemia, Basophilic, Acute; Membrane Potentials; Ornithine Decarboxylase Inhibitors; Potassium Channels; Potassium Channels, Inwardly Rectifying; Putrescine; Rats; Spermidine; Spermine; Tumor Cells, Cultured | 1996 |
Impairment of DNA replication within one cell cycle after seeding of cells in the presence of a polyamine-biosynthesis inhibitor.
Topics: Animals; Bromodeoxyuridine; Cell Cycle; CHO Cells; Cricetinae; DNA; DNA Replication; Eflornithine; Enzyme Inhibitors; Kinetics; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Biosynthesis; Putrescine; RNA; Spermidine; Spermine | 1996 |
First report of the inhibition of arbuscular mycorrhizal infection of Pisum sativum by specific and irreversible inhibition of polyamine biosynthesis or by gibberellic acid treatment.
Topics: Cadaverine; Eflornithine; Enzyme Inhibitors; Fungi; Gibberellins; Mutation; Ornithine Decarboxylase Inhibitors; Pisum sativum; Plant Diseases; Plant Growth Regulators; Plant Roots; Polyamines; Putrescine; Spermidine; Spermine | 1996 |
Effects of polyamine imbalance on the induction of stress genes in hepatocarcinoma cells exposed to heat shock.
Topics: Animals; Cell Division; Eflornithine; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, Immediate-Early; Genes, jun; Heme Oxygenase (Decyclizing); Histones; HSP70 Heat-Shock Proteins; Humans; Kinetics; Liver Neoplasms, Experimental; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; RNA, Messenger; Spermidine; Spermine; Time Factors; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Enhanced tissue polyamine content in the spontaneously hypertensive rat.
Topics: Animals; Blood Vessels; Cardiovascular System; Eflornithine; Enzyme Inhibitors; Heart Ventricles; Liver; Male; Polyamines; Putrescine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spermidine; Spermine | 1996 |
Effects of gestational or neonatal treatment with alpha-difluoromethylornithine on ornithine decarboxylase and polyamines in developing rat brain and on adult rat neurochemistry.
Topics: Animals; Animals, Newborn; Body Weight; Brain Chemistry; Cerebellum; Choline O-Acetyltransferase; Eflornithine; Female; Male; Organ Size; Ornithine Decarboxylase; Polyamines; Pregnancy; Prenatal Exposure Delayed Effects; Prosencephalon; Putrescine; Rats; Rats, Wistar; Spermidine | 1996 |
Polyamine content of Pneumocystis carinii and response to the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornithine.
Topics: Animals; Chromatography, High Pressure Liquid; Eflornithine; Enzyme Inhibitors; Ornithine Decarboxylase Inhibitors; Pneumocystis; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1996 |
Polyamines as modulators of microcycle conidiation in Aspergillus flavus.
Topics: Aspergillus flavus; Cell Division; Cyclohexylamines; Eflornithine; Enzyme Inhibitors; Mitoguazone; Putrescine; Spermidine | 1996 |
Dissimilar activation patterns of the carcinogen dimethylhydrazine (DMH) on intracellular polyamine metabolism in various organs.
Topics: 1,2-Dimethylhydrazine; Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Enzyme Activation; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Wistar; Spermidine; Spermine; Tissue Distribution | 1996 |
Growth arrest- and polyamine-dependent expression of spermidine/spermine N1-acetyltransferase in human tumor cells.
Topics: Acetyltransferases; Blotting, Northern; Cell Division; Colonic Neoplasms; Dactinomycin; Eflornithine; Enzyme Induction; Enzyme Repression; Heat-Shock Response; Humans; Polyamines; Putrescine; RNA; Spermidine; Spermine; Tumor Cells, Cultured | 1996 |
Polyamines increase in the brain stem and cerebellum following labyrinthectomy.
Topics: Analysis of Variance; Animals; Brain Stem; Cerebellum; Chromatography, High Pressure Liquid; Ear, Inner; Eflornithine; Fluorometry; Functional Laterality; Guinea Pigs; Male; Polyamines; Putrescine; Spermidine; Time Factors | 1997 |
Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cells.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Lysine; Mice; Oncogene Protein p21(ras); Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine | 1997 |
Polyamines are important for attachment of IEC-6 cells to extracellular matrix.
Topics: Animals; Cadaverine; Cell Adhesion; Cell Line; Cell Movement; Collagen; Drug Combinations; Eflornithine; Enzyme Inhibitors; Extracellular Matrix; Integrins; Intestinal Mucosa; Intestine, Small; Laminin; Ornithine Decarboxylase; Plastics; Polyamines; Proteoglycans; Putrescine; Rats; Spermidine; Spermine | 1997 |
Polyamines modulate transcription but not posttranscription of c-myc and c-jun in IEC-6 cells.
Topics: Animals; Blood; Cattle; Cell Line; Cell Nucleus; Culture Media; Eflornithine; Genes, jun; Genes, myc; Intestinal Mucosa; Intestine, Small; Kinetics; Polyamines; Protein Biosynthesis; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; Rats; RNA, Messenger; Spermidine; Time Factors; Transcription, Genetic | 1997 |
Rapid induction of apoptosis by deregulated uptake of polyamine analogues.
Topics: Alkylation; Animals; Apoptosis; Cell Death; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; Eflornithine; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Putrescine; Spermidine; Spermine | 1997 |
Characterization of the human antizyme gene.
Topics: Animals; Base Sequence; beta-Galactosidase; Cell Line; Cloning, Molecular; Eflornithine; Enzyme Inhibitors; Genes, Reporter; Humans; Luciferases; Mice; Molecular Sequence Data; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Proteins; Rats; Regulatory Sequences, Nucleic Acid; Restriction Mapping; Sequence Analysis, DNA; Single-Strand Specific DNA and RNA Endonucleases; Spermidine; Transcription, Genetic | 1997 |
Dimethylsilane polyamines: cytostatic compounds with potentials as anticancer drugs.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; CHO Cells; Cricetinae; DNA; Drug Screening Assays, Antitumor; Eflornithine; Enzyme Inhibitors; Leukemia L1210; Mice; Polyamines; Putrescine; Silanes; Spermidine | 1997 |
Differences in transglutaminase mRNA after polyamine depletion in two cell lines.
Topics: Animals; Caco-2 Cells; Cell Line; Eflornithine; Gene Expression Regulation, Enzymologic; Humans; Intestines; Polyamines; Rats; RNA, Messenger; Spermidine; Transglutaminases | 1998 |
Polyamine depletion protects HL-60 cells from 2-deoxy-D-ribose-induced apoptosis.
Topics: Apoptosis; Deoxyribose; DNA Fragmentation; Eflornithine; Enzyme Inhibitors; HL-60 Cells; Humans; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine | 1998 |
Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.
Topics: Animals; Ascites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Eflornithine; Enzyme Inhibitors; Liver Neoplasms, Experimental; Membrane Fluidity; Microscopy, Electron, Scanning; Neoplasm Invasiveness; Putrescine; Rats; Spermidine; Spermine; Tumor Cells, Cultured | 1998 |
Polyamines regulate expression of the neoplastic phenotype in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Apoptosis; Carcinoma, Papillary; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Eflornithine; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ornithine Decarboxylase; Polyamines; Putrescine; Skin; Skin Neoplasms; Spermidine; Spermine | 1998 |
Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines.
Topics: Amidines; Animals; Antineoplastic Agents; Apoptosis; Eflornithine; Enzyme Inhibitors; Fas Ligand Protein; Granulocyte-Macrophage Colony-Stimulating Factor; HeLa Cells; Humans; Indans; Membrane Glycoproteins; Mice; Mitoguazone; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine; T-Lymphocytes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
A polyamine pathway-mediated mitogenic mechanism in enterochromaffin-like cells of Mastomys.
Topics: Animals; Cell Division; Cells, Cultured; DNA; Eflornithine; Enterochromaffin-like Cells; Gastric Mucosa; Gastrins; Muridae; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermine; Transforming Growth Factor alpha | 1998 |
Polyamines in human and rat milk influence intestinal cell growth in vitro.
Topics: Animals; Cattle; Cell Division; Cell Line; Dialysis; DNA; Eflornithine; Humans; Infant Food; Intestines; Milk; Milk, Human; Molecular Weight; Polyamines; Rats; Spermidine; Tritium | 1998 |
Differential effect on polyamine metabolism in mitogen- and superantigen-activated human T-cells.
Topics: Eflornithine; Humans; Interleukin-2; Lymphocyte Activation; Mitogens; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Receptors, Interleukin-2; Spermidine; Superantigens; T-Lymphocytes | 1998 |
Comparative effects of TGFbeta on proliferation of 7- and 14-day-old chick embryo fibroblasts and lack of involvement of the ODC/PA system in the TGFbeta signaling pathway.
Topics: Animals; Cell Cycle; Cell Division; Cells, Cultured; Chick Embryo; Eflornithine; Enzyme Induction; Fibroblasts; Kinetics; Ornithine Decarboxylase; Polyamines; Putrescine; RNA; RNA, Messenger; S Phase; Signal Transduction; Skin; Spermidine; Spermine; Time Factors; Transcription, Genetic; Transforming Growth Factor beta | 1999 |
Intracellular polyamine levels are involved in NMDA-evoked nitric oxide production in chick retina cells.
Topics: Animals; Arginine; Cells, Cultured; Chick Embryo; Citrulline; Cyclic GMP; Eflornithine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glycine; N-Methylaspartate; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Polyamines; Receptors, N-Methyl-D-Aspartate; Retina; Spermidine | 1999 |
Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells.
Topics: Amidines; Animals; Biogenic Polyamines; Breast Neoplasms; Cell Division; Eflornithine; Estradiol; Female; Gene Expression; Humans; Indans; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Receptors, Estrogen; Recombinant Fusion Proteins; Spermidine; Tumor Cells, Cultured | 1999 |
2-deoxy-d-ribose-induced apoptosis in HL-60 cells is associated with the cell cycle progression by spermidine.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Cell Cycle; Deoxyribose; Eflornithine; Flow Cytometry; HL-60 Cells; Humans; Membrane Potentials; Mitochondria; Onium Compounds; Organophosphorus Compounds; Ornithine Decarboxylase Inhibitors; Oxidative Stress; Putrescine; Spermidine; Spermine | 1999 |
Inhibition of polyamine synthesis induces p53 gene expression but not apoptosis.
Topics: Animals; Apoptosis; Cattle; Cell Line; Culture Media; Eflornithine; Gene Expression Regulation; Genes, p53; Intestinal Mucosa; Kinetics; Polyamines; Putrescine; Rats; RNA, Messenger; Spermidine; Spermine; Transcription, Genetic; Tumor Suppressor Protein p53 | 1999 |
Enhanced uptake of [3H] spermidine by 9L rat brain tumors after direct intratumoral infusion of inhibitors of enzymes of the polyamine biosynthetic pathway.
Topics: Adenosylmethionine Decarboxylase; Animals; Biological Transport; Body Weight; Brain Neoplasms; Corpus Striatum; Deoxyadenosines; Eflornithine; Enzyme Inhibitors; Gliosarcoma; Infusions, Parenteral; Male; Oxidoreductases Acting on CH-NH Group Donors; Putrescine; Rats; Rats, Inbred F344; Spermidine; Tritium; Tumor Cells, Cultured | 1999 |
Influence of polyamines on DNA binding of heat shock and activator protein 1 transcription factors induced by heat shock.
Topics: Animals; Base Sequence; Biogenic Polyamines; DNA; DNA Primers; Eflornithine; Half-Life; Heat-Shock Response; HSP70 Heat-Shock Proteins; Protein Binding; Rats; RNA, Messenger; Spermidine; Transcription Factor AP-1; Tumor Cells, Cultured | 1999 |
Probing the mechanism of transport and compartmentalisation of polyamines in mammalian cells.
Topics: Animals; Biological Transport, Active; Cell Compartmentation; Cells, Cultured; CHO Cells; Cricetinae; Culture Media; Eflornithine; Flow Cytometry; Fluorescent Dyes; Humans; Ligands; Microscopy, Fluorescence; Models, Chemical; Models, Molecular; Polyamines; Spermidine; Tumor Cells, Cultured | 1999 |
The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects.
Topics: Animals; Apoptosis; bcl-X Protein; Cell Cycle; Cell Death; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Eflornithine; Hematopoietic Stem Cells; Humans; Interleukin-3; Kinetics; Lysosomes; Mice; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Proto-Oncogene Proteins c-bcl-2; Putrescine; Spermidine; Spermine | 1999 |
Polyamines regulate serine/threonine protein phosphatases in insulin-secreting cells.
Topics: Arginine; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Histones; Humans; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Okadaic Acid; Pancreatic Neoplasms; Phosphoprotein Phosphatases; Phosphorylation; Polyamines; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 2000 |
Changes in gene expression in response to polyamine depletion indicates selective stabilization of mRNAs.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Cell Line; Cloning, Molecular; Down-Regulation; Eflornithine; Expressed Sequence Tags; Gene Expression Regulation; Half-Life; Kidney; Mice; Mice, Transgenic; Molecular Sequence Data; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; RNA Stability; RNA, Messenger; Spermidine; Up-Regulation | 2000 |
Role of K(+) channel expression in polyamine-dependent intestinal epithelial cell migration.
Topics: Animals; Antisense Elements (Genetics); Calcium; Calcium Channels; Cell Movement; Cells, Cultured; Eflornithine; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Image Processing, Computer-Assisted; Intestines; Kv1.1 Potassium Channel; Ornithine Decarboxylase Inhibitors; Polyamines; Potassium Channels; Potassium Channels, Voltage-Gated; Rats; Spermidine | 2000 |
Polyamine depletion delays apoptosis of rat intestinal epithelial cells.
Topics: Animals; Apoptosis; Camptothecin; Caspase 3; Caspases; Cell Adhesion; Cell Line; DNA Fragmentation; Eflornithine; Intestinal Mucosa; Kinetics; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermidine; Spermine | 2000 |
Prolactin stimulation of iodide uptake and incorporation into protein is polyamine-dependent in mouse mammary gland explants.
Topics: Adenosylmethionine Decarboxylase; Animals; Eflornithine; Enzyme Inhibitors; Female; Iodides; Iodine Radioisotopes; Mammary Glands, Animal; Mice; Mitoguazone; Ornithine Decarboxylase Inhibitors; Pregnancy; Prolactin; Proteins; Spermidine | 2000 |
Expression of the TGF-beta receptor gene and sensitivity to growth inhibition following polyamine depletion.
Topics: Activin Receptors, Type I; Animals; Cell Division; Cell Line; Eflornithine; Enzyme Inhibitors; Gene Expression; Humans; Intestine, Small; Laminin; Protein Serine-Threonine Kinases; Putrescine; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA, Messenger; Spermidine; Spermine; Transforming Growth Factor beta; Tretinoin | 2000 |
Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO.
Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Division; Eflornithine; Female; Humans; Indicators and Reagents; Kinetics; Lysine; Male; Melanoma; Mice; Mice, Nude; Molecular Structure; Polyamines; Prostatic Neoplasms; Spermidine; Spermine; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2000 |
Sensitivity of trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase.
Topics: Animals; Crithidia fasciculata; Cycloheximide; Eflornithine; Kinetics; Leishmania mexicana; Ornithine Decarboxylase; Putrescine; Spermidine; Time Factors; Trypanosoma cruzi; Trypanosomatina | 2000 |
NF-kappaB activation and susceptibility to apoptosis after polyamine depletion in intestinal epithelial cells.
Topics: Animals; Apoptosis; Cell Line; Cycloheximide; DNA Fragmentation; Eflornithine; G1 Phase; Intestinal Mucosa; Kinetics; NF-kappa B; Nucleosomes; Polyamines; Putrescine; Rats; Spermidine; Spermine; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha | 2001 |
Polyamine and thiol metabolism in Trypanosoma granulosum: similarities with Trypanosoma cruzi.
Topics: Animals; Biogenic Polyamines; Cadaverine; Culture Media; Eflornithine; Glutathione; Methylhistidines; Ornithine Decarboxylase; Putrescine; Spermidine; Spermine; Sulfhydryl Compounds; Tritium; Trypanosoma; Trypanosoma cruzi | 2001 |
Polyamines regulate gap junction communication in connexin 43-expressing cells.
Topics: Animals; Butadienes; Cell Communication; Cell Line; Cells, Cultured; Connexin 43; Crosses, Genetic; Eflornithine; Embryo, Mammalian; Enzyme Inhibitors; Gap Junctions; Humans; Keratinocytes; Mice; Mice, Knockout; Nitriles; Ornithine Decarboxylase; Putrescine; Recombinant Proteins; Skin; Skin Physiological Phenomena; Spermidine | 2001 |
Changes in polyamines, auxins and peroxidase activity during in vitro rooting of Fraxinus angustifolia shoots: an auxin-independent rooting model.
Topics: Biogenic Polyamines; Cyclohexylamines; Eflornithine; Guanidines; In Vitro Techniques; Indoleacetic Acids; Indoles; Models, Biological; Oleaceae; Peroxidase; Plant Roots; Putrescine; Spermidine; Trees | 2001 |
Effect of inhibitors of polyamine biosynthesis on gibberellin-induced internode growth in light-grown dwarf peas.
Topics: Arginine; Carboxy-Lyases; Cycloheximide; Dactinomycin; Eflornithine; Enzyme Inhibitors; Gibberellins; Pisum sativum; Plant Growth Regulators; Polyamines; Protein Synthesis Inhibitors; Putrescine; RNA, Plant; Spermidine | 1986 |
Kinetic studies on the control of the bean rust fungus (Uromyces phaseoli L.) by an inhibitor of polyamine biosynthesis.
Topics: Carboxy-Lyases; Eflornithine; Enzyme Inhibitors; Fabaceae; Fungi; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plant Diseases; Plant Leaves; Plants, Medicinal; Polyamines; Putrescine; Spermidine; Spores | 1986 |
In vivo inhibition of polyamine biosynthesis and growth in tobacco ovary tissues.
Topics: Adenosylmethionine Decarboxylase; Arginine; Carboxy-Lyases; Eflornithine; Enzyme Inhibitors; Mitoguazone; Nicotiana; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plants, Toxic; Polyamines; Putrescine; Spermidine; Spermine | 1985 |
Effect of polyamine biosynthetic inhibitors on alkaloids and organogenesis in tobacco callus cultures.
Topics: Arginine; Biomass; Carboxy-Lyases; Culture Techniques; Cyclohexylamines; Eflornithine; Enzyme Inhibitors; Nicotiana; Nicotine; Ornithine Decarboxylase Inhibitors; Plant Roots; Plants, Toxic; Polyamines; Putrescine; Spermidine; Spermidine Synthase | 1987 |
Polyamine levels as related to growth, differentiation and senescence in protoplast-derived cultures of Vigna aconitifolia and Avena sativa.
Topics: Arginine; Avena; Carboxy-Lyases; Cell Differentiation; Cell Division; Cells, Cultured; Cellular Senescence; Chlorophyll; Cyclohexylamines; Eflornithine; Enzyme Inhibitors; Fabaceae; Ornithine Decarboxylase Inhibitors; Plant Proteins; Plants, Medicinal; Polyamines; Protoplasts; Putrescine; Spermidine; Spermidine Synthase | 1985 |
Polyamines and the integrity of the plant body.
Topics: Arginine; Carboxy-Lyases; Eflornithine; Ornithine Decarboxylase; Plant Cells; Plant Physiological Phenomena; Plants; Polyamines; Putrescine; Spermidine; Spermine | 1985 |
The effects of some polyamine biosynthetic inhibitors on growth and morphology of phytopathogenic fungi.
Topics: Arginine; Carboxy-Lyases; Eflornithine; Enzyme Inhibitors; Mitosporic Fungi; Ornithine Decarboxylase Inhibitors; Plant Diseases; Polyamines; Putrescine; Rhizoctonia; Spermidine | 1985 |
Amino acid/spermine conjugates: polyamine amides as potent spermidine uptake inhibitors.
Topics: Amino Acids; Antineoplastic Agents; Biological Transport; Drug Interactions; Drug Screening Assays, Antitumor; Eflornithine; Humans; Lysine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Spermidine is essential for normal proliferation of trypanosomatid protozoa.
Topics: Animals; Crithidia fasciculata; Cyclohexylamines; Eflornithine; Enzyme Inhibitors; Ornithine Decarboxylase; Putrescine; Spermidine; Spermidine Synthase; Spermine; Trypanosoma cruzi | 2001 |
Activities of arginase I and II are limiting for endothelial cell proliferation.
Topics: Animals; Arginase; Cattle; Cell Division; Cells, Cultured; Coronary Vessels; Eflornithine; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Isoenzymes; Lac Operon; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Transfection | 2002 |
Characterization of spermine uptake by Ehrlich tumour cells in culture.
Topics: Agmatine; Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Eflornithine; Kinetics; Osmolar Concentration; Spermidine; Spermine; Tumor Cells, Cultured | 2001 |
Quantitation of polyamines in hypothalamus and pituitary of female and male developing rats.
Topics: Agmatine; Animals; Chromatography, High Pressure Liquid; Eflornithine; Enzyme Inhibitors; Female; Hypothalamus; Male; Pituitary Gland; Polyamines; Putrescine; Rats; Rats, Sprague-Dawley; Sex Characteristics; Spermidine; Spermine; Time Factors | 2002 |
Polyamine-dependent migration of retinal pigment epithelial cells.
Topics: Adenosylmethionine Decarboxylase; Cell Line; Cell Movement; Chromatography, High Pressure Liquid; Eflornithine; Enzyme Inhibitors; Humans; Mitoguazone; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Pigment Epithelium of Eye; Putrescine; Spermidine; Spermine | 2002 |
Involvement of polyamines in root development at low temperature in the subantarctic cruciferous species Pringlea antiscorbutica.
Topics: Acclimatization; Agmatine; Antarctic Regions; Arginine; Brassicaceae; Carboxy-Lyases; Cold Temperature; Drug Interactions; Eflornithine; Germination; Glutarates; Mitoguazone; Ornithine Decarboxylase; Plant Roots; Plant Shoots; Polyamines; Putrescine; Seeds; Spermidine; Spermine | 2002 |
Polyamine uptake is necessary for a normal biochemical maturation of astrocytes in culture.
Topics: Animals; Astrocytes; Biogenic Polyamines; Cell Differentiation; Cell Division; Cells, Cultured; Cerebellum; DNA; Down-Regulation; Eflornithine; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Mice; Mitoguazone; Ornithine Decarboxylase; Putrescine; Spermidine; Spermine; Thymidine; Up-Regulation | 2002 |
Effect of spermine conjugation on the cytotoxicity and cellular transport of acridine.
Topics: Acridines; Animals; Binding, Competitive; Biological Transport; Carrier Proteins; Cell Division; Cell Line; Cricetinae; DNA; Eflornithine; Mutation; Ornithine Decarboxylase Inhibitors; Spectrometry, Fluorescence; Spermidine; Spermine | 2002 |
Contribution of spermidine to stimulation by hepatocyte growth factor in repair after damage of rabbit gastric mucosal cells in primary culture.
Topics: Animals; Cells, Cultured; DNA Repair; Eflornithine; Enzyme Inhibitors; Epithelial Cells; Gastric Mucosa; Hepatocyte Growth Factor; Putrescine; Rabbits; Spermidine; Wound Healing | 2003 |
Polyamine metabolism is altered in unpollinated parthenocarpic pat-2 tomato ovaries.
Topics: Carboxy-Lyases; Eflornithine; Flowers; Fruit; Gibberellins; Mutation; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Reproduction; RNA, Plant; Solanum lycopersicum; Spermidine; Spermidine Synthase; Spermine; Triazoles | 2003 |
Polyamines in cultured rabbit corneal cells.
Topics: Animals; Biogenic Polyamines; Cell Division; Cells, Cultured; Corneal Stroma; Dose-Response Relationship, Drug; Eflornithine; Endothelium, Corneal; Enzyme Inhibitors; Epithelium, Corneal; Fibroblasts; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Rabbits; Spermidine; Spermine; Time Factors | 2003 |
Lytic infection of pseudorabies virus in the presence of spermine, spermidine, or DFMO.
Topics: Animals; Biogenic Polyamines; Cell Line; Eflornithine; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Herpesvirus 1, Suid; Mice; Ornithine Decarboxylase Inhibitors; Promoter Regions, Genetic; Radioisotopes; Spermidine; Spermine; Transcription, Genetic; Transfection; Viral Plaque Assay; Viral Proteins | 2003 |
Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast cancer cells.
Topics: Animals; Blotting, Western; Breast Neoplasms; Carcinoma 256, Walker; Cell Line, Tumor; Cell Nucleus; Eflornithine; Female; Gene Expression Regulation, Neoplastic; Humans; Mammary Neoplasms, Experimental; Mice; Neoplasm Proteins; Neoplasm Transplantation; NF-kappa B; NF-kappa B p50 Subunit; Polyamines; Putrescine; Rats; Spermidine; Spermine; Surface Plasmon Resonance; Transcription Factor RelA; Transcriptional Activation | 2004 |
Depletion of polyamines and increase of transforming growth factor-beta1, c-myc, collagen-type I, matrix metalloproteinase-1, and metalloproteinase-2 mRNA in primary human gingival fibroblasts.
Topics: Adult; Cell Count; Cell Proliferation; Cells, Cultured; Collagen Type I; Eflornithine; Enzyme Inhibitors; Extracellular Matrix; Female; Fibroblasts; Gingiva; Humans; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Proto-Oncogene Proteins c-myc; Putrescine; RNA, Messenger; Spermidine; Spermine; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta | 2005 |
Polyamine depletion reduces TNFalpha/MG132-induced apoptosis in bone marrow stromal cells.
Topics: Animals; Antigens, CD34; Apoptosis; Blotting, Western; Bone Marrow Cells; Caspase 3; Caspases; Cell Adhesion; Cell Cycle; Cell Nucleus; Cell Proliferation; Cell Separation; Coloring Agents; Eflornithine; Femur; Flow Cytometry; In Situ Nick-End Labeling; Leukocyte Common Antigens; Leupeptins; Microscopy, Fluorescence; Ornithine Decarboxylase; Osteocytes; Polyamines; Proteasome Inhibitors; Putrescine; Rats; Rats, Wistar; Spermidine; Stromal Cells; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2005 |
Effects of polyamines on two strains of Trypanosoma brucei in infected rats and in vitro culture.
Topics: Amide Synthases; Animals; Culture Media; Eflornithine; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glutathione; Hematocrit; Hydrogen Peroxide; Male; NADH, NADPH Oxidoreductases; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidative Stress; Polyamines; Putrescine; Rats; Rats, Wistar; RNA, Messenger; Spermidine; Spermine; Trypanosoma brucei brucei; Trypanosomiasis, African | 2006 |
Polyamines, PI(4,5)P2, and actin polymerization.
Topics: Actins; Animals; Cells, Cultured; Cytoskeleton; Eflornithine; HL-60 Cells; Humans; PC12 Cells; Phosphatidylinositol 4,5-Diphosphate; Polyamines; Putrescine; Rats; Spermidine; Spermine; Substrate Specificity; Time Factors | 2006 |
Modulation of cell proliferation and polyamine metabolism in rat liver cell cultures by the iron chelator O-trensox.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Replication; Eflornithine; Endothelial Cells; Ethylamines; Hepatocytes; Hydroxyquinolines; Iron Chelating Agents; Liver; Male; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Spermidine | 2006 |
Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Collagen; Drug Combinations; Eflornithine; Ki-67 Antigen; Laminin; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Transplantation; Polyamines; Proteoglycans; Putrescine; Spermidine; Spermine | 2007 |
HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells.
Topics: Animals; Cell Proliferation; CHO Cells; Chromatography, Affinity; Cricetinae; Cricetulus; Eflornithine; Female; Gene Products, tat; Heparin; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Peptide Fragments; Polyamines; Proteoglycans; Spermidine; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2007 |
Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide.
Topics: Animals; Apoptosis; Cells, Cultured; DNA Damage; Eflornithine; Glutathione; Guanidines; Hydrogen Peroxide; In Situ Nick-End Labeling; Mice; Oxidative Stress; Reactive Oxygen Species; Spermidine; Spermine | 2007 |
Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells.
Topics: Animals; Cationic Amino Acid Transporter 1; Cell Line; Dose-Response Relationship, Drug; Eflornithine; Enzyme Inhibitors; Epithelial Cells; Humans; Large Neutral Amino Acid-Transporter 1; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Ornithine-Oxo-Acid Transaminase; Pigment Epithelium of Eye; Proto-Oncogene Proteins c-myc; Putrescine; RNA Interference; RNA, Messenger; RNA, Small Interfering; Spermidine; Spermine; Swine; Telomerase; Time Factors; Transfection; Up-Regulation | 2007 |
Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.
Topics: alpha-Amylases; Animals; Animals, Genetically Modified; Cell Proliferation; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Humans; Kinetics; Lysine; Models, Biological; Pancreatitis; Peptide Initiation Factors; Polyamines; Rats; Recombinant Proteins; RNA-Binding Proteins; Spermidine; Stereoisomerism | 2007 |
Validation of spermidine synthase as a drug target in African trypanosomes.
Topics: Amino Acid Sequence; Animals; Eflornithine; Models, Biological; Molecular Sequence Data; Recombinant Proteins; RNA Interference; Spermidine; Spermidine Synthase; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2008 |
Synergistic antitumor effects of anthracenylmethyl homospermidine and alpha-difluoromethylornithine on promyelocytic leukemia HL60 cells.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Caspase Inhibitors; Caspases; Cell Cycle; Cell Proliferation; Cytochromes c; Drug Synergism; Eflornithine; Enzyme Inhibitors; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; HL-60 Cells; Humans; Membrane Potentials; Mitochondrial Membranes; Spermidine | 2008 |
Effects of polyamines and polyamine biosynthetic inhibitors on mitotic activity of Allium cepa root tips.
Topics: Cycloheximide; Eflornithine; Enzyme Inhibitors; Meristem; Mitoguazone; Mitosis; Onions; Polyamines; Protein Synthesis Inhibitors; Putrescine; Spermidine; Spermine | 2008 |
Spermine-induced morphogenesis and effect of partial immersion system on the shoot cultures of banana.
Topics: Agriculture; Arginine; Eflornithine; Morphogenesis; Musa; Plant Shoots; Putrescine; Spermidine; Spermine | 2008 |
Role of putrescine on androgen-elicited positive inotropism in the left atrium of rats.
Topics: Adrenergic beta-Agonists; Androgens; Animals; Atrial Function; Cardiotonic Agents; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Dihydrotestosterone; Eflornithine; Heart Atria; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Wistar; Spermidine; Spermine | 2008 |
Putrescine modulation of acute activation of the beta-adrenergic system in the left atrium of rat.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Chromatography, High Pressure Liquid; Cyclic AMP; Dihydroalprenolol; Eflornithine; Enzyme Inhibitors; Heart; Heart Atria; Isoproterenol; Male; Membranes; Myocardium; Putrescine; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Spermidine; Spermine | 2008 |
Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Eflornithine; Enzyme Inhibitors; Exploratory Behavior; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Maze Learning; Memory; Memory Disorders; Motor Activity; Prefrontal Cortex; Putrescine; Rats; Rats, Sprague-Dawley; Space Perception; Spatial Behavior; Spermidine; Spermine | 2009 |
Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Cell Differentiation; Cell Proliferation; Cell Shape; Eflornithine; Fibroblasts; Gene Expression Regulation; Glucose Transporter Type 4; Isomerism; Lipid Metabolism; Mice; Organ Specificity; Putrescine; Spermidine; Time Factors | 2010 |
Augmented bladder urothelial polyamine signaling and block of BK channel in the pathophysiology of overactive bladder syndrome.
Topics: Cells, Cultured; Eflornithine; Electrophysiology; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Humans; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Ornithine Decarboxylase; Polyamines; Signal Transduction; Spermidine; Spermine; Urinary Bladder; Urinary Bladder, Overactive; Urothelium; Young Adult | 2009 |
Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway.
Topics: Apoptosis; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Proliferation; Eflornithine; Enzyme Activation; Fluorescence; Humans; Intracellular Signaling Peptides and Proteins; Intracellular Space; Membrane Transport Proteins; Naphthalimides; Neoplasm Proteins; Phosphorylation; Polyamines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Spermidine; TOR Serine-Threonine Kinases | 2009 |
The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation.
Topics: Animals; Cell Proliferation; Drosophila; Eflornithine; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Mice; NIH 3T3 Cells; Peptide Chain Elongation, Translational; Peptide Chain Initiation, Translational; Peptide Initiation Factors; Phosphorylation; RNA-Binding Proteins; Spermidine; Yeasts | 2010 |
Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract.
Topics: Animals; Biological Transport; Catalysis; Caveolae; Caveolin 1; Cell Line, Tumor; Colonic Neoplasms; Drug Combinations; Eflornithine; Endocytosis; Enzyme Inhibitors; Fusion Regulatory Protein 1, Heavy Chain; Gastrointestinal Tract; Humans; Mice; Mice, Knockout; Nitric Oxide Synthase; Putrescine; Spermidine | 2010 |
The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism.
Topics: Acetyltransferases; Alternative Splicing; Animals; Cell Line, Tumor; Cell Proliferation; Eflornithine; Humans; Mice; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Recombinant Proteins; RNA Precursors; RNA, Messenger; Spermidine; Structure-Activity Relationship | 2011 |
Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyamines.
Topics: Animals; CELF1 Protein; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase 4; Eflornithine; Enzyme Assays; Epithelial Cells; Gene Expression Regulation; Gene Silencing; Genes, Reporter; Intestinal Mucosa; Luciferases, Firefly; MicroRNAs; Open Reading Frames; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Binding; Protein Biosynthesis; Putrescine; Rats; Recombinant Proteins; RNA-Binding Proteins; RNA, Messenger; Spermidine; Spermine; Transcription, Genetic | 2011 |
Studies on cell migration model in intestinal epithelial restitution for pharmacological research.
Topics: Animals; Astragalus propinquus; Cell Culture Techniques; Cell Line; Cell Migration Assays; Cell Movement; Culture Media; Eflornithine; Epithelial Cells; Intestinal Mucosa; Intestines; Models, Biological; Polysaccharides; Rats; Spermidine; Wound Healing | 2011 |
Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats.
Topics: Agmatine; Animals; Antineoplastic Agents; Behavior, Animal; Eflornithine; Enzyme Inhibitors; Hippocampus; Learning Disabilities; Male; Maze Learning; Memory; Memory Disorders; Organ Specificity; Ornithine Decarboxylase Inhibitors; Prefrontal Cortex; Putrescine; Random Allocation; Rats; Rats, Sprague-Dawley; Spatial Behavior; Spermidine; Toxicity Tests, Chronic | 2012 |
Suppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area.
Topics: Cell Line; Eflornithine; Enzyme Inhibitors; Gene Expression Regulation; Humans; Leukocytes, Mononuclear; Lymphocyte Function-Associated Antigen-1; Methylation; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Promoter Regions, Genetic; Spermidine; Spermine | 2013 |
Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A.
Topics: 3T3-L1 Cells; Adipogenesis; Animals; Eflornithine; ELAV Proteins; Female; Male; Mice; Nuclear Proteins; Polyamines; Protein Phosphatase 2; Rats; Rats, Wistar; Spermidine | 2013 |
Polyamine depletion inhibits the autophagic response modulating Trypanosoma cruzi infectivity.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; CHO Cells; Cricetinae; Cricetulus; Eflornithine; Embryo, Mammalian; Epithelial Cells; Fibroblasts; Mice; Mice, Knockout; Microtubule-Associated Proteins; Myocytes, Cardiac; Phagosomes; Polyamines; Spermidine; Time Factors; Trypanosoma cruzi | 2013 |
Polyamine inhibitors for treatment of feline oral squamous cell carcinoma: a proof-of-concept study.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cat Diseases; Cats; Eflornithine; Evoked Potentials, Auditory, Brain Stem; Female; Hearing; Hearing Loss; Male; Mouth Mucosa; Mouth Neoplasms; Polyamines; Putrescine; Spermidine; Spermine; Thrombocytopenia | 2013 |
A quantitative proteomic screen to identify potential drug resistance mechanism in α-difluoromethylornithine (DFMO) resistant Leishmania donovani.
Topics: Biomarkers; Chromatography, Liquid; Drug Resistance; Eflornithine; Free Radicals; Glutathione; GTP Phosphohydrolases; Leishmania donovani; Mass Spectrometry; Ornithine Decarboxylase; Peptides; Polyamines; Protein Folding; Proteomics; Signal Transduction; Spermidine; Subcellular Fractions | 2014 |
Inhibition of polyamine formation antagonizes vascular smooth muscle cell proliferation and preserves the contractile phenotype.
Topics: Animals; Cattle; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Eflornithine; Inhibitory Concentration 50; Male; Muscle Contraction; Muscle, Smooth, Vascular; Ornithine Decarboxylase; Phenotype; Putrescine; Rats; Rats, Sprague-Dawley; Spermidine; Spermine | 2014 |
Spermidine, a sensor for antizyme 1 expression regulates intracellular polyamine homeostasis.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Line; Eflornithine; Homeostasis; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Proteins; Putrescine; Rats; Spermidine; Spermine | 2014 |
Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.
Topics: Biological Transport; Cell Line, Tumor; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Humans; Lysine; Male; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine; Stereoisomerism; Substrate Specificity | 2015 |
Suppression of ornithine decarboxylase promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
Topics: Adipogenesis; Bone Marrow Cells; Bone Matrix; Calcification, Physiologic; Cell Proliferation; Cells, Cultured; Eflornithine; Gene Expression Regulation, Developmental; Humans; Kinetics; Lipid Metabolism; Mesenchymal Stem Cells; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Osteogenesis; Putrescine; RNA Interference; RNA, Small Interfering; Spermidine; Spermine | 2015 |
Polyamine biosynthesis is critical for growth and differentiation of the pancreas.
Topics: Animals; Cell Differentiation; Eflornithine; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Insulin-Secreting Cells; Morpholinos; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Pancreas; Phenotype; Polyamines; Spermidine; Stem Cells; Zebrafish | 2015 |
Inhibition of Polyamine Uptake Potentiates the Anti-Proliferative Effect of Polyamine Synthesis Inhibition and Preserves the Contractile Phenotype of Vascular Smooth Muscle Cells.
Topics: Animals; Biogenic Polyamines; Biological Transport; Caveolin 1; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Eflornithine; Gene Expression Regulation; Humans; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Ornithine Decarboxylase Inhibitors; Phenotype; Polyamines; Putrescine; Spermidine; Time Factors; Tissue Culture Techniques; Vasoconstriction | 2016 |
Extracellular Spermine Activates DNA Methyltransferase 3A and 3B.
Topics: Adenosylmethionine Decarboxylase; Cell Line, Tumor; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA Modification Methylases; Eflornithine; Epithelial Cells; Humans; Jurkat Cells; Mammary Glands, Human; Ornithine Decarboxylase; Polyamines; Putrescine; S-Adenosylmethionine; Spermidine; Spermine | 2019 |
A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes.
Topics: Biosensing Techniques; Eflornithine; Glutathione; Green Fluorescent Proteins; Homeostasis; Hydrogen Peroxide; Mitochondria; Oxidation-Reduction; Oxidative Stress; Spermidine; Thioredoxins; Trypanocidal Agents; Trypanosoma brucei brucei | 2020 |
KLF4 is required for suppression of histamine synthesis by polyamines during bone marrow-derived mast cell differentiation.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Eflornithine; Female; Histamine; Histidine Decarboxylase; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mast Cells; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Ornithine Decarboxylase; Polyamines; Secretory Vesicles; Spermidine | 2020 |
The involvement of polyamine uptake and synthesis pathways in the proliferation of neonatal astrocytes.
Topics: Animals; Astrocytes; Cell Proliferation; Cells, Cultured; Eflornithine; Polyamines; Protein Transport; Rats; Rats, Sprague-Dawley; Spermidine; Spermine | 2020 |
Effects of Spermidine on Cell Proliferation, Migration, and Inflammatory Response in Porcine Enterocytes.
Topics: Animals; Cell Proliferation; Cytokines; Eflornithine; Enterocytes; Lipopolysaccharides; Putrescine; Spermidine; Swine; Tumor Necrosis Factor-alpha | 2022 |
Elucidating the Role of
Topics: Animals; Drosophila melanogaster; Eflornithine; Polyamines; Putrescine; Spermidine; Spermine | 2022 |
Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome.
Topics: Eflornithine; Humans; Male; Polyamines; Spermidine; Spermine; Spermine Synthase | 2023 |