spermidine has been researched along with dizocilpine maleate in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 56 (81.16) | 18.2507 |
| 2000's | 10 (14.49) | 29.6817 |
| 2010's | 3 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perry, EK; Perry, RH; Piggott, MA; Sahgal, A | 1 |
| Benavides, J; Bourdiol, F; Carter, C; Fage, D; Porcella, A; Scatton, B; Voltz, C | 1 |
| Enomoto, R; Han, D; Ogita, K; Yoneda, Y | 2 |
| Court, JA; Perry, EK; Perry, RH; Piggott, MA | 1 |
| Reynolds, IJ | 3 |
| Benavides, J; Bourdiol, F; Carter, C; Fage, D; Scatton, B; Serrano, A | 1 |
| Carter, C; Fage, D; Scatton, B; Voltz, C | 1 |
| Cler, JA; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Johnson, KM; Sacaan, AI | 1 |
| Canton, H; Colpaert, F; Lehmann, J | 1 |
| Daw, N; Gordon, B; Parkinson, D | 1 |
| Frusciante, MJ; Javitt, DC; Nussenzveig, IZ; Sircar, R; Wong, ML; Zukin, SR | 1 |
| Enomoto, R; Ogita, K; Yoneda, Y | 2 |
| Molinoff, PB; Romano, C; Williams, K | 1 |
| de Belleroche, J; Reed, LJ | 1 |
| Ogita, K; Yoneda, Y | 1 |
| Bowen, DM; Cross, AJ; Francis, PT; Green, AR; Steele, JE | 1 |
| Aizenman, E; Reynolds, IJ; Rush, EA | 1 |
| Dawson, VL; Dichter, MA; Molinoff, PB; Romano, C; Williams, K | 1 |
| Aronstam, RS; Martin, DC | 1 |
| Fahey, JM; Miller, LG; Pritchard, GA | 1 |
| Belknap, JK; Carter, LA; Crabbe, JC; Janowsky, A | 1 |
| London, ED; Mukhin, A | 1 |
| Andou, Y; Enomoto, R; Kataoka, K; Mitani, A; Ogita, K; Yoneda, Y | 1 |
| Doyle, KM; Shaw, GG | 1 |
| Ingram, DK; London, ED; Shimada, A; Spangler, EL | 1 |
| Masukawa, LM; McGonigle, P; O'Connor, MJ; Subramaniam, S | 1 |
| Anegawa, NJ; Dichter, M; Lawrence, JJ; Lenz, S; Lynch, DR; Pritchett, DB | 1 |
| Carter, C; Fage, D; Nicolas, C | 1 |
| Frusciante, MJ; Javitt, DC; Zukin, SR | 1 |
| Lewis, SJ; Ohta, H; Talman, WT | 1 |
| McGonigle, P; Subramaniam, S | 2 |
| Burns, MA; Palmer, AM | 1 |
| Carter, C; Fage, D; Voltz, C | 1 |
| Bresink, I; Danysz, W; Mutschler, E; Parsons, CG; Tiedtke, P | 1 |
| Gallagher, MJ; Huang, H; Lynch, DR; Pritchett, DB | 1 |
| Chen, X; Hurlbert, M; Joseph, DB; Kumar, KN; Michaelis, EK; Michaelis, ML | 1 |
| Berger, ML; Khomutov, AR; Rebernik, P | 1 |
| Gallagher, MJ; Lynch, DR | 1 |
| McCoy, L; Richfield, EK | 1 |
| Ogita, K; Shuto, M; Yoneda, Y | 1 |
| Gallagher, MJ; Grant, ER; Huang, H; Lynch, DR | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Gandolfi, O; Sparapani, M | 1 |
| Misawa, M; Shimizu, N; Suzuki, T; Tsuda, M; Yajima, Y | 1 |
| Gallagher, MJ; Huang, H; Lynch, DR | 1 |
| Reynolds, IJ; Sharma, TA | 2 |
| Kishi, A; Ohno, M; Watanabe, S | 1 |
| Hinoi, E; Ogita, K; St'astny, F; Yoneda, Y | 1 |
| Gallagher, MJ; Grant, ER; Lynch, DR; Shim, SS; Singh, S | 1 |
| Calderón, F; López, E; López-Colomé, AM; Pichardo, I | 1 |
| Bence, AK; Crooks, PA; Fu, M; Gibson, DA; Littleton, JM; Rogers, DT; Worthen, DR | 1 |
| Gallagher, MJ; Guttmann, RP; Kurapathi, S; Lynch, DR; Mutel, V; Seifert, KM; Shim, SS | 1 |
| Chen, XQ; Hu, GY; Wang, Y; Yang, HH; Zhang, YH; Zhao, XY | 1 |
| Gibson, DA; Harris, BR; Littleton, JM; Rogers, DT | 1 |
| Littleton, JM; Mulholland, PJ; Nath, A; Prendergast, MA; Rogers, DT; Self, RL; Wilkins, LH | 1 |
| Honse, Y; Leslie, SW; Randall, PK | 1 |
| Hozumi, S; Kisara, K; Murata, A; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Yamadera, F | 1 |
| Peña, C; Reinés, A; Rodríguez de Lores Arnaiz, G; Zárate, S | 1 |
| Bellé, NA; Dalmolin, GD; Fonini, G; Rocha, JB; Rubin, MA | 1 |
| Camera, K; Ceretta, AP; Mello, CF; Rubin, MA | 1 |
| Berry, JN; Butler, TR; Littleton, JM; Mulholland, PJ; Pauly, JR; Prendergast, MA; Self, RL; Sharrett-Field, LJ; Smith, KJ | 1 |
| Carvalho, FB; Ferreira, J; Girardi, BA; Marisco, PC; Mello, CF; Oliveira, MS; Rubin, MA; Tonello, R | 1 |
| da Silva Junior, PI; dos Santos, WF; Godoy, LD; Liberato, JL | 1 |
69 other study(ies) available for spermidine and dizocilpine maleate
| Article | Year |
|---|---|
Examination of parameters influencing [3H]MK-801 binding in postmortem human cortex.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Cadaver; Cerebral Cortex; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Spermidine; Time Factors; Tritium; Zinc | 1992 |
Implication of the polyamines in the neurotoxic effects of N-methyl-D-aspartate.
Topics: Animals; Cell Membrane; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Glutamate Decarboxylase; Infusions, Parenteral; Isoquinolines; Microinjections; N-Methylaspartate; Neurotoxins; Rats; Receptors, GABA-A; Spermidine; Spermine; Tetrodotoxin | 1992 |
Differential modulation by divalent cations of [3H]MK-801 binding in brain synaptic membranes.
Topics: Animals; Brain; Calcium; Cell Fractionation; Dizocilpine Maleate; Ion Channels; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes; Zinc | 1992 |
[3H]MK-801 binding to the NMDA receptor complex, and its modulation in human frontal cortex during development and aging.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Child, Preschool; Dizocilpine Maleate; Female; Glutamates; Glycine; Humans; Infant; Infant, Newborn; Kinetics; Male; Middle Aged; Prefrontal Cortex; Pregnancy; Receptors, N-Methyl-D-Aspartate; Spermidine; Zinc | 1992 |
Interactions between zinc and spermidine on the N-methyl-D-aspartate receptor complex: clues to the mechanism of action of 1,10-bis(guanidino)decane and pentamidine.
Topics: Animals; Biguanides; Binding Sites; Brain Chemistry; Diethyl Pyrocarbonate; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Guanidines; Pentamidine; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Zinc | 1992 |
Neurotoxic effects of the intrastriatal injection of spermine and spermidine: lack of involvement of NMDA receptors.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Glutamate Decarboxylase; Injections; Male; Nervous System; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1992 |
Selective release of spermine and spermidine from the rat striatum by N-methyl-D-aspartate receptor activation in vivo.
Topics: Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dizocilpine Maleate; Kainic Acid; Male; Polyamines; Potassium; Putrescine; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1992 |
1,5-(Diethylamino)piperidine, a novel spermidine analogue that more specifically activates the N-methyl-D-aspartate receptor-associated polyamine site.
Topics: Allosteric Regulation; Animals; Binding Sites; Dizocilpine Maleate; Kinetics; Magnesium; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 1992 |
Polyamines modulate events mediated by the N-methyl-D-aspartate (NMDA) receptor complex through an ifenprodil-insensitive pathway: in vivo measurements of cyclic GMP in the cerebellum.
Topics: Animals; Biogenic Polyamines; Cerebellum; Cyclic GMP; Dizocilpine Maleate; Injections, Intraventricular; Male; Methamphetamine; Mice; Neural Pathways; Ornithine; Pentylenetetrazole; Piperidines; Putrescine; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
Regulation of polyamine and magnesium inhibition of the N-methyl-D-aspartate (NMDA) receptor ionophore complex.
Topics: Animals; Biogenic Polyamines; Dizocilpine Maleate; Erythrocyte Membrane; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Magnesium; Phencyclidine; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Structure-Activity Relationship | 1991 |
Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Biguanides; Binding, Competitive; Biogenic Polyamines; Biotransformation; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
The effect of age on binding of MK-801 in the cat visual cortex.
Topics: Aging; Animals; Cats; Darkness; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Magnesium; Receptors, N-Methyl-D-Aspartate; Spermidine; Visual Cortex | 1991 |
Polyamine effects upon N-methyl-D-aspartate receptor functioning: differential alteration by glutamate and glycine site antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kinetics; Kynurenic Acid; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermidine | 1991 |
Characterization of spermidine-dependent [3H](+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) binding in brain synaptic membranes treated with Triton X-100.
Topics: Animals; Binding Sites; Brain; Dizocilpine Maleate; Glucose; Glycine; Kinetics; Octoxynol; Polyethylene Glycols; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes | 1991 |
Polyamines modulate the binding of [3H]MK-801 to the solubilized N-methyl-D-aspartate receptor.
Topics: Animals; Brain; Dizocilpine Maleate; Intracellular Membranes; Male; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Tritium | 1991 |
Induction of ornithine decarboxylase in cerebral cortex by excitotoxin lesion of nucleus basalis: association with postsynaptic responsiveness and N-methyl-D-aspartate receptor activation.
Topics: Animals; Basal Ganglia; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Eflornithine; Enzyme Induction; Excitatory Amino Acid Antagonists; Glutamic Acid; Ibotenic Acid; Kainic Acid; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxazoles; Pentobarbital; Phosphatidylinositol Phosphates; Phosphatidylinositols; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Substantia Innominata; Synapses | 1990 |
Solubilization of spermidine-sensitive (+)-[3H]5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine ([3H]MK-801) binding activity from rat brain.
Topics: Animals; Binding, Competitive; Brain; Dizocilpine Maleate; Drug Synergism; Glutamates; Glutamic Acid; Glycine; Rats; Rats, Inbred Strains; Solubility; Spermidine; Stereoisomerism; Tritium | 1990 |
Spermidine enhancement of [3H]MK-801 binding to the NMDA receptor complex in human cortical membranes.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Cerebral Cortex; Dizocilpine Maleate; Female; Humans; In Vitro Techniques; Kynurenic Acid; Male; Membranes; Piperidines; Radioligand Assay; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine | 1990 |
Reduction of NMDA receptors with dithiothreitol increases [3H]-MK-801 binding and NMDA-induced Ca2+ fluxes.
Topics: Animals; Calcium; Dithionitrobenzoic Acid; Dithiothreitol; Dizocilpine Maleate; Fluorescence; Fura-2; Glutamates; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine | 1990 |
Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor.
Topics: Biguanides; Binding, Competitive; Biogenic Polyamines; Dibenzocycloheptenes; Dizocilpine Maleate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine | 1990 |
Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor.
Topics: Animals; Binding Sites; Cells, Cultured; Diamines; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Conductivity; Glutamates; Glycine; Hippocampus; Kinetics; Magnesium; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Zinc | 1990 |
Spermidine attenuation of volatile anesthetic inhibition of glutamate-stimulated [3H](5D,10S)-(+)-methyl-10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5,10-imine ([3H]MK-801) binding to N-methyl-D-aspartate (NMDA) receptors in rat brain.
Topics: Anesthetics, Inhalation; Animals; Brain; Depression, Chemical; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spermidine; Stimulation, Chemical; Tritium | 1995 |
Polyamine neurotoxicity is antagonized by dizocilpine in cultured chick cortical neurons.
Topics: Animals; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Cortex; Chick Embryo; Dizocilpine Maleate; Ion Channels; Nervous System; Neurons; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1993 |
Supporting evidence for negative modulation by protons of an ion channel associated with the N-methyl-D-aspartate receptor complex in rat brain using ligand binding techniques.
Topics: Animals; Brain Chemistry; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Channels; Ligands; Male; Protons; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes | 1994 |
Allosteric regulation of the N-methyl-D-aspartate receptor-linked ion channel complex and effects of ethanol in ethanol-withdrawal seizure-prone and -resistant mice.
Topics: Allosteric Regulation; Animals; Cerebral Cortex; Dizocilpine Maleate; Ethanol; Genetic Predisposition to Disease; Glycine; Hippocampus; Ion Channels; Male; Mice; Mice, Mutant Strains; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Seizures; Spermidine; Substance Withdrawal Syndrome | 1995 |
Polyamines as endogenous modulators of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1995 |
Binding of [3H]MK-801, NMDA-displaceable [3H]glutamate, [3H]glycine, [3H]spermidine, [3H]kainate and [3H]AMPA to regionally discrete brain membranes of the gerbil: a biochemical study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Cell Membrane; Dizocilpine Maleate; Female; Gerbillinae; Glutamates; Glutamic Acid; Glycine; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Receptors, Glutamate; Spermidine; Thiocyanates; Tissue Distribution | 1993 |
The mechanism of the neurotoxic effects of spermidine.
Topics: Animals; Cerebral Ventricles; Dizocilpine Maleate; Guanidines; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurotoxins; Oxidoreductases Acting on CH-NH Group Donors; Piperidines; Putrescine; Receptors, N-Methyl-D-Aspartate; Spermidine; Stereotyped Behavior | 1994 |
Spermidine potentiates dizocilpine-induced impairment of learning performance by rats in a 14-unit T-maze.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Drug Synergism; Injections, Intraperitoneal; Male; Maze Learning; Memory; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Spermidine | 1994 |
Polyamine effects on the NMDA receptor in human brain.
Topics: Adult; Animals; Brain; Cadaver; Cerebral Cortex; Diamines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Male; Middle Aged; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine | 1994 |
Pharmacological characterization of heterodimeric NMDA receptors composed of NR 1a and 2B subunits: differences with receptors formed from NR 1a and 2A.
Topics: Animals; Brain; Cell Survival; Dizocilpine Maleate; Electrophysiology; Membranes; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Transfection | 1995 |
NMDA receptors with different sensitivities to magnesium and ifenprodil control the release of [14C]acetylcholine and [3H]spermidine from rat striatal slices in vitro.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aminoquinolines; Animals; Carbon Radioisotopes; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Magnesium; Magnesium Chloride; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 1994 |
Activation-related and activation-independent effects of polyamines on phencyclidine receptor binding within the N-methyl-D-aspartate receptor complex.
Topics: Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Spermidine | 1994 |
Differential potentiation by spermidine of abilities of a variety of displacers for [3H]MK-801 binding in hippocampal synaptic membranes.
Topics: Animals; Binding, Competitive; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Wistar; Spermidine; Synaptic Membranes; Synaptosomes | 1993 |
Spermidine and cardiovascular control in nucleus tractus solitarii in rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cardiovascular System; Dizocilpine Maleate; Dose-Response Relationship, Drug; Heart Rate; Male; Methylene Blue; Microinjections; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Spermidine | 1993 |
Regional profile of developmental changes in the sensitivity of the N-methyl-D-aspartate receptor to polyamines.
Topics: Aging; Animals; Brain; Dizocilpine Maleate; Hippocampus; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Thalamus | 1994 |
Preservation of redox, polyamine, and glycine modulatory domains of the N-methyl-D-aspartate receptor in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Biguanides; Binding Sites; Brain; Cell Membrane; Cerebral Cortex; Dithionitrobenzoic Acid; Dizocilpine Maleate; Female; Frontal Lobe; Glycine; Humans; Male; Middle Aged; Organ Specificity; Oxidation-Reduction; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Spermidine; Temporal Lobe | 1994 |
Regional heterogeneity of polyamine effects on the N-methyl-D-aspartate receptor in rat brain.
Topics: Analysis of Variance; Animals; Autoradiography; Brain; Cell Membrane; Cerebral Cortex; Corpus Striatum; Diamines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hypothalamus; Kinetics; Male; Organ Specificity; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 1993 |
Ouabain releases striatal polyamines in vivo independently of N-methyl-D-aspartate receptor activation.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Male; N-Methylaspartate; Ouabain; Piperazines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1993 |
Chronic treatment with the uncompetitive NMDA receptor antagonist memantine influences the polyamine and glycine binding sites of the NMDA receptor complex in aged rats.
Topics: Aging; Animals; Binding Sites; Cerebral Cortex; Dizocilpine Maleate; Dopamine Agents; Glycine; Male; Maze Learning; Memantine; Neuroprotective Agents; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine | 1995 |
Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Arginine; Base Sequence; Binding Sites; Cell Line; Cloning, Molecular; Dizocilpine Maleate; DNA Primers; Excitatory Amino Acid Antagonists; Genetic Variation; Humans; Kidney; Kinetics; Macromolecular Substances; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Piperidines; Polymerase Chain Reaction; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Spermidine; Transfection | 1996 |
Ethanol-induced inhibition of [3H]thienylcyclohexylpiperidine (TCP) binding to NMDA receptors in brain synaptic membranes and to a purified protein complex.
Topics: Animals; Brain Chemistry; Dizocilpine Maleate; Dopamine Antagonists; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Haloperidol; Illicit Drugs; Kinetics; Male; Membrane Proteins; N-Methylaspartate; Phencyclidine; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensitivity and Specificity; Spermidine; Synaptic Membranes; Tritium | 1996 |
Aminooxy-analogues of spermidine: new partial agonists and antagonists at the polyamine site of the rat hippocampal NMDA receptor complex.
Topics: Animals; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine | 1996 |
Inhibition of N-methyl-D-aspartate receptors by haloperidol: developmental and pharmacological characterization in native and recombinant receptors.
Topics: Animals; Antipsychotic Agents; Dizocilpine Maleate; Haloperidol; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Recombinant Proteins; Spermidine | 1996 |
Washable endogenous substances and regional heterogeneity in agonist enhanced [3H]MK-801 binding in rat brain.
Topics: Animals; Autoradiography; Binding Sites; Brain; Dizocilpine Maleate; Glycine; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Spermidine; Temperature; Therapeutic Irrigation; Time Factors; Tissue Distribution; Tritium | 1996 |
Modulation by both diphenyliodonium and diphenyleneiodonium of [3H]MK-801 binding to rat brain synaptic membranes.
Topics: Animals; Biphenyl Compounds; Brain; Diamines; Dizocilpine Maleate; Drug Evaluation, Preclinical; Drug Synergism; Enzyme Inhibitors; Free Radicals; Male; Nitric Oxide Synthase; Onium Compounds; Radioligand Assay; Rats; Rats, Wistar; Spermidine; Synaptic Membranes | 1997 |
The NR2B-specific interactions of polyamines and protons with the N-methyl-D-aspartate receptor.
Topics: Amino Acid Sequence; Base Sequence; Cell Line; Dizocilpine Maleate; DNA Primers; Glutamic Acid; Glycine; Humans; Macromolecular Substances; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Protons; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Sequence Alignment; Spermidine; Transfection | 1997 |
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E | 1997 |
Hypersusceptibility to DMCM-induced seizures during diazepam withdrawal in mice: evidence for upregulation of NMDA receptors.
Topics: Animals; Anticonvulsants; Carbolines; Cerebral Cortex; Convulsants; Diazepam; Dizocilpine Maleate; Male; Membranes; Mice; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Seizures; Spermidine; Substance Withdrawal Syndrome; Up-Regulation | 1998 |
Modulation of the N-methyl-D-aspartate receptor by haloperidol: NR2B-specific interactions.
Topics: Amino Acid Sequence; Binding, Competitive; Chimera; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Humans; Mutagenesis, Site-Directed; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine | 1998 |
Complex polyamine effects on [3H]MDL 105,519 binding to the NMDA receptor glycine site.
Topics: Aminoquinolines; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Indoles; Kynurenic Acid; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Tritium | 1998 |
Concurrent activation of hippocampal glycine and polyamine sites of the N-methyl-D-aspartate receptor synergistically reverses working memory deficits in rats.
Topics: Animals; Antimetabolites; Cycloserine; Dizocilpine Maleate; Drug Synergism; Glycine; Hippocampus; Injections, Intraventricular; Male; Memory Disorders; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine | 1998 |
Ferrous iron modulates quinolinate-mediated [3H]MK-801 binding to rat brain synaptic membranes in the presence of glycine and spermidine.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Binding Sites; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ferrous Compounds; Glutamic Acid; Glycine; Inhibitory Concentration 50; Kynurenic Acid; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes | 1999 |
Actions of butyrophenones and other antipsychotic agents at NMDA receptors: relationship with clinical effects and structural considerations.
Topics: Animals; Antipsychotic Agents; Butyrophenones; Dizocilpine Maleate; Iodine Radioisotopes; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermidine | 1999 |
Characterization of the effects of polyamines on [125I]MK-801 binding to recombinant N-methyl-D-aspartate receptors.
Topics: Algorithms; Alternative Splicing; Animals; Brain; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fibroblasts; In Vitro Techniques; Membranes; Mice; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermidine; Spermine | 1999 |
[3H]Spermine binding to synaptosomal membranes from the chick retina.
Topics: Animals; Chickens; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kinetics; Polyamines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Retina; Spermidine; Spermine; Synaptosomes; Tritium | 1999 |
Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex.
Topics: Animals; Binding, Competitive; Biogenic Polyamines; Brain; Cell Membrane; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Indoles; Ligands; Neuroprotective Agents; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Subcellular Fractions; Tritium | 2001 |
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.
Topics: Animals; Brain; Cell Line; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Humans; Kinetics; Mice; Mutation; Phenols; Piperidines; Protein Structure, Tertiary; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Spermidine | 2001 |
Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex.
Topics: Alkaloids; Alzheimer Disease; Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Cholinesterase Inhibitors; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Neurons; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes; Spermidine; Synaptic Membranes | 2002 |
Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil.
Topics: Agmatine; Animals; Biguanides; Binding Sites; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 2002 |
Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor.
Topics: Animals; ATPases Associated with Diverse Cellular Activities; Biguanides; Brain; Cerebellum; Cerebral Cortex; Culture Techniques; Dizocilpine Maleate; DNA-Binding Proteins; Excitatory Amino Acid Antagonists; Female; Hippocampus; HIV-1; Male; Neurons; Neurotoxins; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine | 2002 |
Prenatal ethanol exposure modifies [3H]MK-801 binding to NMDA receptors: spermidine and ifenprodil.
Topics: Alternative Splicing; Animals; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Female; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 2003 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizocilpine Maleate; Drug Therapy, Combination; Injections, Intraventricular; Male; Memory Disorders; Mice; N-Methylaspartate; Olfactory Bulb; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine; Time Factors | 2004 |
The effect of endogenous modulator endobain E on NMDA receptor is interfered by Zn2+ but is independent of modulation by spermidine.
Topics: Animals; Dizocilpine Maleate; Male; Ouabain; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium; Zinc | 2004 |
Polyamines reduces lipid peroxidation induced by different pro-oxidant agents.
Topics: Animals; Antioxidants; Biguanides; Biogenic Polyamines; Dizocilpine Maleate; Edetic Acid; Iron; Lipid Peroxidation; Nitroprusside; Oxidants; Quinolinic Acid; Rats; Rats, Wistar; Spermidine; Spermine; Thiobarbituric Acid Reactive Substances | 2004 |
Systemic administration of polyaminergic agents modulate fear conditioning in rats.
Topics: Animals; Behavior, Animal; Biguanides; Conditioning, Classical; Dizocilpine Maleate; Fear; Injections, Intraperitoneal; Male; Memory; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Time Factors | 2007 |
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Valine | 2010 |
Spermidine decreases Na⁺,K⁺-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats.
Topics: Animals; Biguanides; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dizocilpine Maleate; Enzyme Activation; Hippocampus; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Spermidine | 2012 |
Mygalin: a new anticonvulsant polyamine in acute seizure model and neuroethological schedule.
Topics: Acute Disease; Animals; Anticonvulsants; Cognition; Diazepam; Dizocilpine Maleate; Drug Evaluation, Preclinical; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Antagonists; Exploratory Behavior; Locomotion; Male; Maze Learning; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Rotarod Performance Test; Spermidine | 2013 |