Page last updated: 2024-08-21

spectinomycin and trospectomycin

spectinomycin has been researched along with trospectomycin in 46 studies

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (32.61)	18.7374
1990's	28 (60.87)	18.2507
2000's	1 (2.17)	29.6817
2010's	2 (4.35)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Bale, MJ; Erwin, ME; Gerlach, EH; Jones, RN; Koontz, FP; Murray, PR; Washington, JA	2
Dennis, EJ; Filler, L; Nelson, GH; Shipley, CF	1
Schaadt, RD; Yagi, BH; Zurenko, GE	1
Watanakunakorn, C	2
Bodey, GP; Jeffery-Wiseman, C; Khardori, N; Nguyen, H; Tewari, RP; Wallin, E; Wong, E	1
Keefer, MC; Long, M; Menegus, MA; Nasello, MA; Reichman, RC; Reid, JA	1
Chisari, G; Gismondo, MR; Lo Bue, AM	1
Bye, A; Nichols, DJ; Novak, E	1
Burrows, M; Bye, A; Constable, DA; Dring, LG; Jeffrey, P; Nichols, DJ	1
Cox, JW; Cramer, CT; Gray, JE; Larsen, ER; Petrella, DK; Piper, RC; Ulrich, RG	1
Daley, B; LiPuma, JJ; Stull, TL	1
Adame, J; Bodey, GP; Gandhi, M; Kalvakuntla, L; Khardori, N; Rosenbaum, B	1
Johnson, CC; Levison, ME; Wendeler, M	1
Batts, DH; Bye, A; Francom, SF; Nichols, DJ; Novak, E; Peters, GR	1
Adams, LD; Cialdella, JI; Liggett, WF; Marshall, VP; Ulrich, RG	1
Bye, A; Francom, SF; Novak, E; Patel, R; Paxton, LM; Zurenko, GE	1
Bodey, GP; Ho, DH; Rolston, K	1
Barry, AL; Jones, RN; Thornsberry, C	1
Ferguson, DA; Lambe, DW; Verhoef, J; Veringa, EM	1
Cox, JW; Epps, DE; Ginsberg, LC; Larsen, ER; McKenna, R; Ulrich, RG; Wynalda, MA	1
Cox, JW; Cramer, CT; Larson, PG; Ulrich, RG	1
Arlet, G; Casin, IM; Perol, Y; Sanson-Le Pors, MJ; Thebault, MC	1
Conti, CR; Franzini, D; Lawson, D; Mehta, J; Nichols, WW; Ward, MB; Wargovich, TJ	1
Vavra, JJ; Wentworth, BB; Yagi, BH; Zurenko, GE	1
Grayston, JT; Kuo, CC	1
Jacobus, NV; Tally, FP	1
Casin, I; Felten, A; Perol, Y; Sanson-Le Pors, MJ	1
Klein, LK; Yancey, RJ	1
Argoudelis, AD; Baczynskyj, L; Mizsak, SA; Yagi, Y	1
Ford, CW; Novak, E; Zurenko, GE	1
Peeters, M; Piot, P; Van Dyck, E	1
Debets-Ossenkopp, YJ; MacLaren, DM; Namavar, F	1
Galandiuk, S; Lamos, J; Montgomery, W; Polk, HC; Young, S	1
Landman, D; Mobarakai, N; Quale, JM	1
Leonik, KJ; Martin, DH; Millikan, LE; Mroczkowski, TF	1
Appelbaum, PC; Jacobs, MR; Spangler, SK	1
Czinn, SJ; Midkiff, BR; Westblom, TU	1
Fagerness, PE; Hiyama, Y; Likar, MD; Robins, RH; Taylor, RJ	1
Bacon, JA; Cramer, CT; Peng, GW; Petrella, DK; Stryd, RP; Sun, EL; Ulrich, RG	1
Amsterdam, D; Beam, TR; Gorzynski, EA; Rotstein, C	1
Chisari, G; Lo Bue, AM; Nicoletti, G	1
Ba, JL; Jin, F; Liu, CG	1

Reviews

1 review(s) available for spectinomycin and trospectomycin

Article	Year
Cultured hepatocytes as investigational models for hepatic toxicity: practical applications in drug discovery and development. Toxicology letters, 1995, Volume: 82-83 Topics: Animals; Cells, Cultured; Cryopreservation; Humans; Liver; Oxadiazoles; Quinoxalines; Spectinomycin	1995

Trials

4 trial(s) available for spectinomycin and trospectomycin

Article	Year
Postcesarean endometritis: a brief review and comparison of three antibiotic regimens. Journal of the South Carolina Medical Association (1975), 1992, Volume: 88, Issue:6 Topics: Anti-Bacterial Agents; Cesarean Section; Double-Blind Method; Endometritis; Female; Humans; Postoperative Complications; Pregnancy; Puerperal Infection; Spectinomycin	1992
Single-dose trospectomycin for chlamydial urethritis in men. Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:5 Topics: Adolescent; Adult; Anti-Infective Agents; Chlamydia Infections; Humans; Injections, Intramuscular; Male; Middle Aged; Spectinomycin; Urethritis	1991
Multiple-dose, double-blind, placebo controlled intravenous tolerance and pharmacokinetic study of trospectomycin sulfate (U-63, 366F) in healthy male volunteers. International journal of clinical pharmacology, therapy, and toxicology, 1990, Volume: 28, Issue:9 Topics: Adult; Anti-Infective Agents; Double-Blind Method; Humans; Injections, Intramuscular; Injections, Intravenous; Male; Spectinomycin	1990
Human safety and pharmacokinetics of a single intramuscular dose of a novel spectinomycin analog, trospectomycin (U-63,366F). Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:12 Topics: Adolescent; Adult; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Clostridioides difficile; Double-Blind Method; Electrocardiography; Feces; Humans; Injections, Intramuscular; Male; Microbial Sensitivity Tests; Middle Aged; Spectinomycin	1990

Other Studies

41 other study(ies) available for spectinomycin and trospectomycin

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
MIC quality control guidelines for Haemophilus susceptibility tests using cefdinir (FK482), cefepime, cefetamet, cefpirome, ceftibuten, fleroxacin, temafloxacin, clarithromycin, RP59500, and trospectomycin. Journal of clinical microbiology, 1992, Volume: 30, Issue:1 Topics: Anti-Bacterial Agents; Cefdinir; Cefpirome; Ceftibuten; Ceftizoxime; Cephalosporins; Clarithromycin; Erythromycin; Fleroxacin; Fluoroquinolones; Haemophilus; Humans; Microbial Sensitivity Tests; Quality Control; Quinolones; Spectinomycin; Virginiamycin	1992
Disk diffusion quality control guidelines for Haemophilus susceptibility tests using cefdinir, CI-960, fleroxacin, temafloxacin, and trospectomycin. Journal of clinical microbiology, 1992, Volume: 30, Issue:3 Topics: Anti-Bacterial Agents; Cefdinir; Cephalosporins; Fleroxacin; Fluoroquinolones; Haemophilus influenzae; Microbial Sensitivity Tests; Quality Control; Quinolones; Spectinomycin	1992
The bactericidal activity and postantibiotic effect of trospectomycin. Diagnostic microbiology and infectious disease, 1992, Volume: 15, Issue:5 Topics: Anti-Bacterial Agents; Bacteria; Bacteroides fragilis; Chloramphenicol; Clindamycin; Dose-Response Relationship, Drug; Enterococcus faecalis; Escherichia coli; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Moraxella catarrhalis; Moxalactam; Neisseria gonorrhoeae; Spectinomycin; Staphylococcus epidermidis	1992
Lack of synergy between vancomycin and trospectomycin against enterococci isolated from blood cultures. The Journal of antimicrobial chemotherapy, 1992, Volume: 29, Issue:4 Topics: Anti-Bacterial Agents; Blood; Drug Synergism; Drug Therapy, Combination; Enterococcus; Spectinomycin; Vancomycin	1992
Effect of subinhibitory concentrations of clindamycin and trospectomycin on the adherence of Staphylococcus epidermidis in an in vitro model of vascular catheter colonization. The Journal of infectious diseases, 1991, Volume: 164, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Adhesion; Catheters, Indwelling; Clindamycin; Humans; Microscopy, Electron, Scanning; Polysaccharides, Bacterial; Sonication; Spectinomycin; Staphylococcus epidermidis	1991
In vitro activity against aerobes and anaerobes of trospectomycin versus spectinomycin. Drugs under experimental and clinical research, 1991, Volume: 17, Issue:2 Topics: Anti-Bacterial Agents; Culture Media; Drug Resistance, Microbial; Gram-Negative Aerobic Bacteria; Gram-Negative Anaerobic Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Spectinomycin	1991
Pharmacokinetics of trospectomycin sulphate in healthy subjects after single intravenous and intramuscular doses. British journal of clinical pharmacology, 1991, Volume: 32, Issue:2 Topics: Adolescent; Adult; Half-Life; Humans; Infusions, Intravenous; Injections, Intramuscular; Male; Middle Aged; Spectinomycin	1991
In-vitro activity of trospectomycin against enterococci isolated from blood and other clinical materials. The Journal of antimicrobial chemotherapy, 1991, Volume: 27, Issue:6 Topics: Anti-Bacterial Agents; Enterococcus faecalis; Microbial Sensitivity Tests; Spectinomycin; Streptococcus	1991
Pharmacokinetics and fate of 3H-trospectomycin sulphate, a novel aminocyclitol antibiotic, in male and female rats. Xenobiotica; the fate of foreign compounds in biological systems, 1991, Volume: 21, Issue:7 Topics: Animals; Biological Availability; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Feces; Female; Half-Life; Hydrolysis; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Male; Rats; Rats, Inbred Strains; Spectinomycin	1991
Hepatic changes produced by 30-day administration of a novel aminocyclitol antibiotic, trospectomycin sulfate, to laboratory animals. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1990, Volume: 14, Issue:1 Topics: Acid Phosphatase; Alanine Transaminase; Animals; Anti-Infective Agents; Aspartate Aminotransferases; Dogs; Female; Liver; Male; Rats; Rats, Inbred Strains; Spectinomycin	1990
In-vitro activities of trospectomycin, cefpodoxime, and second-generation cephalosporins against Haemophilus influenzae type b. The Journal of antimicrobial chemotherapy, 1990, Volume: 25, Issue:4 Topics: Anti-Bacterial Agents; Cefpodoxime; Ceftizoxime; Cephalosporins; Haemophilus influenzae; Microbial Sensitivity Tests; Spectinomycin	1990
The activity in vitro of trospectomycin sulphate (U-63366F) against aminoglycoside-resistant enterococci. The Journal of antimicrobial chemotherapy, 1990, Volume: 25, Issue:5 Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Microbial; Drug Synergism; Immunoglobulins; Serum Bactericidal Test; Spectinomycin; Streptococcus	1990
In vitro susceptibilities of oral pigmented Bacteroides species to trospectomycin and other selected antimicrobial agents. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:8 Topics: Anti-Bacterial Agents; Bacteroides; Drug Resistance, Microbial; Microbial Sensitivity Tests; Spectinomycin	1990
Effects of trospectomycin on serum sensitivity of Escherichia coli UC 9451. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:11 Topics: Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Blood Bactericidal Activity; Cell Membrane; Complement Pathway, Alternative; Complement Pathway, Classical; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gentamicins; Humans; Microbial Sensitivity Tests; Microscopy, Electron; Spectinomycin	1990
In vitro activity of trospectomycin (U-63366F), a novel spectinomycin analog, against gram-positive isolates from cancer patients. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1989, Volume: 8, Issue:3 Topics: Amikacin; Anti-Bacterial Agents; Cephalothin; Gram-Positive Bacteria; Humans; Neoplasms; Spectinomycin; Staphylococcus; Streptococcus; Vancomycin	1989
Antibacterial activity of trospectomycin (U-63366F) and initial evaluations of disk diffusion susceptibility tests. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:4 Topics: Anti-Bacterial Agents; Bacteria; Drug Resistance, Microbial; Evaluation Studies as Topic; Microbial Sensitivity Tests; Spectinomycin	1989
Trospectomycin enhances surface phagocytosis of Bacteroides and Staphylococcus by altering the bacterial glycocalyx. Zentralblatt fur Bakteriologie : international journal of medical microbiology, 1989, Volume: 271, Issue:3 Topics: Anti-Bacterial Agents; Bacteroides; Blood Bactericidal Activity; Glycoproteins; Neutrophils; Opsonin Proteins; Phagocytosis; Polysaccharides; Spectinomycin; Staphylococcus	1989
Reversible, hepatic, lysosomal phospholipidosis in rat induced by subchronic daily administration of trospectomycin sulfate. Biochemical pharmacology, 1989, Oct-15, Volume: 38, Issue:20 Topics: Animals; Anti-Infective Agents; Female; Lipidoses; Liver; Lysosomes; Male; Phospholipids; Rats; Rats, Inbred Strains; Spectinomycin	1989
Acute hepatocellular effects of erythromycin, gentamicin, and trospectomycin in the perfused rat liver: lack of correlation between lamellar body induction potency and cytotoxicity. Pharmacology & toxicology, 1988, Volume: 62, Issue:5 Topics: Animals; Bile; Erythromycin; Gentamicins; Inclusion Bodies; Liver; Male; Microscopy, Electron; Perfusion; Rats; Rats, Inbred Strains; Spectinomycin	1988
In vitro activities of U-63366, a spectinomycin analog; roxithromycin (RU 28965), a new macrolide antibiotic; and five quinolone derivatives against Haemophilus ducreyi. Antimicrobial agents and chemotherapy, 1986, Volume: 30, Issue:3 Topics: Anti-Bacterial Agents; Drug Resistance, Microbial; Haemophilus ducreyi; Leucomycins; Quinolines; Spectinomycin	1986
Reduction in myocardial neutrophil accumulation and infarct size following administration of thromboxane inhibitor U-63,557A. American heart journal, 1987, Volume: 114, Issue:5 Topics: Animals; Creatine Kinase; Hemodynamics; Leukocyte Count; Male; Myocardial Infarction; Myocardium; Neutrophils; Platelet Aggregation; Rats; Spectinomycin; Thromboxane A2; Thromboxane-A Synthase	1987
In vitro antibacterial activity of trospectomycin (U-63366F), a novel spectinomycin analog. Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:2 Topics: Anti-Bacterial Agents; Bacteria; Chemical Phenomena; Chemistry; Chlamydia trachomatis; Microbial Sensitivity Tests; Spectinomycin	1988
In vitro drug susceptibility of Chlamydia sp. strain TWAR. Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:2 Topics: Ampicillin; Anti-Bacterial Agents; Chlamydia; Erythromycin; Humans; Penicillin G; Spectinomycin; Sulfisoxazole; Tetracycline	1988
Activity of trospectomycin against Bacteroides fragilis and other Bacteroides species. Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:4 Topics: Anti-Bacterial Agents; Bacteroides; Bacteroides fragilis; Humans; Injections, Intravenous; Microbial Sensitivity Tests; Spectinomycin	1988
Biotypes, serotypes, and susceptibility to antibiotics of 60 Haemophilus influenzae strains from genitourinary tracts. Genitourinary medicine, 1988, Volume: 64, Issue:3 Topics: Adult; Drug Resistance, Microbial; Female; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Penicillinase; Serotyping; Spectinomycin; Tetracycline Resistance; Urogenital System	1988
In-vitro activity of trospectomycin sulphate against Mycoplasma and Ureaplasma species isolated from humans. The Journal of antimicrobial chemotherapy, 1988, Volume: 21, Issue:6 Topics: Anti-Bacterial Agents; Drug Resistance, Microbial; Humans; Mycoplasma; Mycoplasma pneumoniae; Spectinomycin; Ureaplasma	1988
Adenylylation of trospectomycin by crude enzyme preparations from Escherichia coli. The Journal of antibiotics, 1988, Volume: 41, Issue:10 Topics: Adenosine Monophosphate; Cell-Free System; Drug Resistance; Escherichia coli; Hydrolysis; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Plasmids; Recombination, Genetic; Spectinomycin	1988
Trospectomycin, a novel spectinomycin analogue: antibacterial activity and preliminary human pharmacokinetics. Drugs under experimental and clinical research, 1988, Volume: 14, Issue:6 Topics: Chromatography, High Pressure Liquid; Gram-Negative Bacteria; Gram-Positive Bacteria; Half-Life; Humans; Spectinomycin	1988
In vitro activities of the spectinomycin analog U-63366 and four quinolone derivatives against Neisseria gonorrhoeae. Antimicrobial agents and chemotherapy, 1984, Volume: 26, Issue:4 Topics: 4-Quinolones; Anti-Bacterial Agents; Ciprofloxacin; Microbial Sensitivity Tests; Nalidixic Acid; Neisseria gonorrhoeae; Norfloxacin; Quinolines; Quinolones; Spectinomycin	1984
Effect of an acidic environment on the susceptibility of Helicobacter pylori to trospectomycin and other antimicrobial agents. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1995, Volume: 14, Issue:4 Topics: Ampicillin; Anti-Bacterial Agents; Azithromycin; Clarithromycin; Clindamycin; Helicobacter pylori; Humans; Hydrogen-Ion Concentration; Metronidazole; Microbial Sensitivity Tests; Spectinomycin	1995
Antibiotic penetration of experimental intra-abdominal abscesses. The American surgeon, 1995, Volume: 61, Issue:6 Topics: Abdominal Abscess; Ampicillin; Animals; Anti-Bacterial Agents; Bacteroides fragilis; Bacteroides Infections; Cefmetazole; Cefoxitin; Ceftriaxone; Clindamycin; Drug Evaluation, Preclinical; Drug Therapy, Combination; Escherichia coli Infections; Hydrogen-Ion Concentration; Male; Mice; Microbial Sensitivity Tests; Spectinomycin; Sulbactam	1995
In-vitro activity of trospectomycin, a new aminocyclitol antibiotic, against multidrug-resistant Enterococcus faecium. The Journal of antimicrobial chemotherapy, 1994, Volume: 33, Issue:2 Topics: Anti-Bacterial Agents; Drug Resistance, Microbial; Enterococcus faecium; Microbial Sensitivity Tests; Spectinomycin	1994
Treatment of gonococcal infections with a single 250 mg intramuscular injection of trospectomycin sulphate vs ceftriaxone sodium. Drugs under experimental and clinical research, 1993, Volume: 19, Issue:1 Topics: Adolescent; Adult; Ceftriaxone; Female; Gonorrhea; Humans; Injections, Intramuscular; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillin Resistance; Spectinomycin	1993
Susceptibility of 539 gram-positive and gram-negative anaerobes to new agents, including RP59500, biapenem, trospectomycin and piperacillin/tazobactam. The Journal of antimicrobial chemotherapy, 1993, Volume: 32, Issue:2 Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; Drug Combinations; Drug Therapy, Combination; Gram-Negative Anaerobic Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Spectinomycin; Tazobactam; Thienamycins; Virginiamycin	1993
In vitro susceptibility of Helicobacter pylori to trospectomycin, pirlimycin (U-57930E), mirincamycin (U-24729A) and N-demethyl clindamycin (U-26767A). European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1993, Volume: 12, Issue:7 Topics: Clindamycin; Drug Resistance, Microbial; Helicobacter pylori; Metronidazole; Microbial Sensitivity Tests; Spectinomycin	1993
The 3'-keto-diol equilibrium of trospectomycin sulfate bulk drug and freeze-dried formulation: solid-state carbon-13 cross-polarization magic angle spinning (CP/MAS) and high-resolution carbon-13 nuclear magnetic resonance (NMR) spectroscopy studies. Pharmaceutical research, 1993, Volume: 10, Issue:1 Topics: Carbon Isotopes; Dimethyl Sulfoxide; Freeze Drying; Magnetic Resonance Spectroscopy; Spectinomycin	1993
In-vitro activity of trospectromycin against gram-positive cocci. The Journal of antimicrobial chemotherapy, 1995, Volume: 36, Issue:5 Topics: Drug Resistance, Microbial; Gram-Positive Cocci; Humans; Microbial Sensitivity Tests; Spectinomycin	1995
The in vitro activity of trospectomycin against anaerobic bacteria. Journal of chemotherapy (Florence, Italy), 1995, Volume: 7, Issue:6 Topics: Ampicillin; Anti-Bacterial Agents; Bacteria, Anaerobic; Clindamycin; Female; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Penicillins; Spectinomycin	1995
Alterations in hormonal receptor expression and HER2 status between primary breast tumors and paired nodal metastases: discordance rates and prognosis. Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:21 Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Female; Humans; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Spectinomycin; Survival Rate	2014