spa-s-132 has been researched along with steffimycin* in 1 studies
1 other study(ies) available for spa-s-132 and steffimycin
Article | Year |
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Screening of antibiotics preferentially active against ras oncogene-expressed cells.
During the course of in vitro screening of agents which are preferentially active against ras oncogene-expressed cells, a new anthracycline (identified as 2-demethylsteffimycin D) and a heptaene (possibly a new member of partricins) were isolated from microbial fermentation broths. Among known compounds tested, 5-fluorouracil, 5-fluorodeoxyuridine and oxanosine showed high selectivity towards ras oncogene-expressed cells. Topics: Animals; Anthracyclines; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Cell Line; Cell Line, Transformed; Chromatography, High Pressure Liquid; Gene Expression Regulation, Neoplastic; Genes, ras; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Polyenes; Streptomyces | 1990 |