Page last updated: 2024-09-02

soyasapogenol b and oleanolic acid

soyasapogenol b has been researched along with oleanolic acid in 34 studies

Compound Research Comparison

Studies (soyasapogenol b)	Trials (soyasapogenol b)	Recent Studies (post-2010) (soyasapogenol b)	Studies (oleanolic acid)	Trials (oleanolic acid)	Recent Studies (post-2010) (oleanolic acid)
37	1	15	4,169	31	2,404

Protein Interaction Comparison

Protein	Taxonomy	oleanolic acid (IC50)
Aldo-keto reductase family 1 member B10	Homo sapiens (human)	2.045
Phospholipase A2	Homo sapiens (human)	3
DNA polymerase beta	Homo sapiens (human)	6.8667
DNA polymerase beta	Rattus norvegicus (Norway rat)	5.6
Receptor-type tyrosine-protein phosphatase C	Homo sapiens (human)	1
Receptor-type tyrosine-protein phosphatase F	Homo sapiens (human)	3.065
Tissue factor	Homo sapiens (human)	0.005
Tyrosine-protein phosphatase non-receptor type 2	Homo sapiens (human)	4.38
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)	2.8444
Liver carboxylesterase 1	Homo sapiens (human)	0.1
Tyrosine-protein phosphatase non-receptor type 6	Homo sapiens (human)	3.065
M-phase inducer phosphatase 2	Homo sapiens (human)	0.98
Dual specificity protein phosphatase 3	Homo sapiens (human)	5.4
Transcription factor p65	Homo sapiens (human)	2.4
Tyrosine-protein phosphatase non-receptor type 11	Homo sapiens (human)	3.065
Protease	Human immunodeficiency virus 1	8

Research

Studies (34)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	17 (50.00)	29.6817
2010's	13 (38.24)	24.3611
2020's	4 (11.76)	2.80

Authors

Authors	Studies
Berhow, MA; Plewa, MJ; Vaughn, SF; Wagner, ED	1
Kurosawa, Y; Shiraiwa, M; Takahara, H	1
Badger, TM; Berhow, MA; Rowlands, JC	1
Gu, L; Gu, W; Prior, RL; Tao, G	1
Hayashi, H; Huang, P; Inoue, K	1
Dalluge, JJ; Eliason, E; Frazer, S	1
Hirakawa, T; Kinjo, J; Nagao, T; Nohara, T; Okabe, H; Okawa, M; Tsuchihashi, R	1
Bewley, JD; Di Berardo, C; Jackson, CJ; Jenkinson, J; Poysa, V; Rupasinghe, HP	1
Murakami, T; Sumida, N; Watanabe, M; Yanai, K	2
Gurfinkel, DM; Rao, AV	1
Hendrich, S; Hu, J; Murphy, PA; Reddy, MB	1
Kuzuhara, H; Minowa, N; Nishiyama, S; Sasaki, K	1
Hendrich, S; Lee, SO; Murphy, PA; Simons, AL	1
Gurfinkel, DM; Rao, AV; Reynolds, WF	1
Popovich, DG; Zhang, W	1
Balestrazzi, A; Biazzi, E; Cammareri, M; Confalonieri, M; Conicella, C; Fevereiro, MP; Pecchia, P; Tava, A	1
Ebizuka, Y; Nishimura, K; Shibuya, M; Yasuyama, N	1
Gotoh, T; Hokari, M; Hori, K; Sugiyama, T; Takahashi, S	1
Du, X; Li, J; Pei, Y; Zhao, H	1
Chu, XW; Deng, H; Lu, XC; Luo, HJ; Mao, LM; Sun, SX; Ye, JF; Zha, LY	1
Andolfi, A; Cimmino, A; Evidente, A; Fernández-Aparicio, M; Melck, D; Rubiales, D	1
Chung, IM; Kim, EH; Kim, HS; Kim, SL; Ro, HM	1
Fukushima, EO; Muranaka, T; Ohyama, K; Saito, K; Sawai, S; Seki, H; Suzuki, M	1
Kamo, S; Sato, T; Suzuki, S	1
Kim, DH; Yoo, DH	1
Avato, P; Biazzi, E; Mella, M; Quadrelli, P; Tava, A	1
Hwang, YH; Jeong, JJ; Kim, DH; Ko, DB; Lee, HJ; Lim, SM	1
Sha, L; Sui, Y; Wang, L; Wang, X; Yun, L; Zhang, H	1
Feng, X; Jiang, G; Liu, H; Sui, W; Wang, J; Wang, L; Zhao, H	1
Feng, T; Ma, L; Song, D; Zhi, L	1
Li, M; Lu, W; Wei, P; Zhang, C; Zhao, M	1
Kim, SH; Kwon, IK; Lee, JY; Park, KR; Yun, HM	1
Pan, C; Yan, Y; Zhao, D	1

Trials

1 trial(s) available for soyasapogenol b and oleanolic acid

Article	Year
Soyasaponin I and sapongenol B have limited absorption by Caco-2 intestinal cells and limited bioavailability in women. The Journal of nutrition, 2004, Volume: 134, Issue:8 Topics: Administration, Oral; Adult; Biological Availability; Caco-2 Cells; Female; Humans; Intestinal Absorption; Oleanolic Acid; Saponins	2004

Other Studies

33 other study(ies) available for soyasapogenol b and oleanolic acid

Article	Year
Characterization and antimutagenic activity of soybean saponins. Mutation research, 2000, Mar-14, Volume: 448, Issue:1 Topics: Animals; Antimutagenic Agents; Carcinogens; Chemical Fractionation; CHO Cells; Cricetinae; Fluorenes; Glycine max; Molasses; Molecular Structure; Mutagenicity Tests; Mutagens; Oleanolic Acid; Plant Extracts; Pyrones; Quinolines; Saponins	2000
UDP-glucuronic acid:soyasapogenol glucuronosyltransferase involved in saponin biosynthesis in germinating soybean seeds. Planta, 2002, Volume: 215, Issue:4 Topics: Carbon Radioisotopes; Cations; Chromatography, Gel; Chromatography, Ion Exchange; Enzyme Activation; Germination; Glucuronosyltransferase; Glycine max; Hydrogen-Ion Concentration; Kinetics; Magnesium; Microsomes; Oleanolic Acid; Saponins; Seeds; Solubility; Substrate Specificity; Temperature; Uridine Diphosphate Glucuronic Acid	2002
Estrogenic and antiproliferative properties of soy sapogenols in human breast cancer cells in vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2002, Volume: 40, Issue:12 Topics: Blotting, Northern; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Estrogens; Estrogens, Non-Steroidal; Female; Fulvestrant; Gene Expression; Glycine max; Humans; Isoflavones; Oleanolic Acid; Phytoestrogens; Plant Extracts; Plant Preparations; Receptors, Estrogen; RNA, Messenger; Saponins; Tumor Cells, Cultured	2002
Determination of soyasaponins in soy with LC-MS following structural unification by partial alkaline degradation. Journal of agricultural and food chemistry, 2002, Nov-20, Volume: 50, Issue:24 Topics: Chromatography, High Pressure Liquid; Glycine max; Hydrogen-Ion Concentration; Oleanolic Acid; Saponins; Spectrometry, Mass, Electrospray Ionization	2002
Up-regulation of soyasaponin biosynthesis by methyl jasmonate in cultured cells of Glycyrrhiza glabra. Plant & cell physiology, 2003, Volume: 44, Issue:4 Topics: Acetates; Cells, Cultured; Cyclopentanes; Farnesyl-Diphosphate Farnesyltransferase; Glucuronosyltransferase; Glycyrrhiza; Intramolecular Transferases; Oleanolic Acid; Oxylipins; RNA, Messenger; Saponins	2003
Simultaneous identification of soyasaponins and isoflavones and quantification of soyasaponin Bb in soy products, using liquid chromatography/electrospray ionization-mass spectrometry. Journal of agricultural and food chemistry, 2003, Jun-04, Volume: 51, Issue:12 Topics: Chromatography, High Pressure Liquid; Glycine max; Isoflavones; Oleanolic Acid; Saponins; Spectrometry, Mass, Electrospray Ionization	2003
Hepatoprotective constituents in plants. 14. Effects of soyasapogenol B, sophoradiol, and their glucuronides on the cytotoxicity of tert-butyl hydroperoxide to HepG2 cells. Biological & pharmaceutical bulletin, 2003, Volume: 26, Issue:9 Topics: Carbohydrate Sequence; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Glucuronides; Glycyrrhizic Acid; Humans; Liver; Molecular Sequence Data; Oleanolic Acid; Saponins; tert-Butylhydroperoxide	2003
Soyasapogenol A and B distribution in soybean (Glycine max L. Merr.) in relation to seed physiology, genetic variability, and growing location. Journal of agricultural and food chemistry, 2003, Sep-24, Volume: 51, Issue:20 Topics: Germination; Glycine max; Isoflavones; Oleanolic Acid; Saponins; Seedlings; Seeds; Water	2003
A novel saponin hydrolase from Neocosmospora vasinfecta var. vasinfecta. Applied and environmental microbiology, 2004, Volume: 70, Issue:2 Topics: Amino Acid Sequence; Ascomycota; Base Sequence; Glycine max; Hydrolases; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Saponins; Sequence Analysis, DNA; Trichoderma	2004
Soyasaponins: the relationship between chemical structure and colon anticarcinogenic activity. Nutrition and cancer, 2003, Volume: 47, Issue:1 Topics: Acetylation; Anticarcinogenic Agents; Cell Division; Colonic Neoplasms; Fabaceae; Fermentation; Humans; Molecular Structure; Oleanolic Acid; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured	2003
Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model. Bioorganic & medicinal chemistry, 2005, Aug-15, Volume: 13, Issue:16 Topics: Animals; Concanavalin A; Crystallography, X-Ray; Disease Models, Animal; Hepatitis, Animal; Liver; Liver Function Tests; Male; Mice; Mice, Inbred BALB C; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins	2005
Soyasaponins lowered plasma cholesterol and increased fecal bile acids in female golden Syrian hamsters. Experimental biology and medicine (Maywood, N.J.), 2005, Volume: 230, Issue:7 Topics: Animals; Anticholesteremic Agents; Bile Acids and Salts; Cholesterol; Cricetinae; Feces; Female; Glycine max; Mesocricetus; Oleanolic Acid; Saponins; Sterols	2005
Cloning and characterization of saponin hydrolases from Aspergillus oryzae and Eupenicillium brefeldianum. Bioscience, biotechnology, and biochemistry, 2005, Volume: 69, Issue:11 Topics: Amino Acid Sequence; Aspergillus oryzae; Cloning, Molecular; Glycoproteins; Hydrolases; Molecular Weight; Oleanolic Acid; Saponins; Sequence Homology; Substrate Specificity; Trioses	2005
The isolation of soyasaponins by fractional precipitation, solid phase extraction, and low pressure liquid chromatography. International journal of food sciences and nutrition, 2005, Volume: 56, Issue:7 Topics: Chromatography, Liquid; Fractional Precipitation; Glycine max; Oleanolic Acid; Saponins	2005
Effect of soyasapogenol A and soyasapogenol B concentrated extracts on HEP-G2 cell proliferation and apoptosis. Journal of agricultural and food chemistry, 2008, Apr-23, Volume: 56, Issue:8 Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cell Line, Tumor; Chromatography, High Pressure Liquid; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Mass Spectrometry; Oleanolic Acid; Plant Extracts; Saponins	2008
Enhanced triterpene saponin biosynthesis and root nodulation in transgenic barrel medic (Medicago truncatula Gaertn.) expressing a novel beta-amyrin synthase (AsOXA1) gene. Plant biotechnology journal, 2009, Volume: 7, Issue:2 Topics: Aster Plant; Gene Expression; Intramolecular Transferases; Medicago truncatula; Oleanolic Acid; Plant Leaves; Plant Proteins; Plant Roots; Plants, Genetically Modified; RNA, Plant; Saponins; Triterpenes	2009
Identification and characterization of glycosyltransferases involved in the biosynthesis of soyasaponin I in Glycine max. FEBS letters, 2010, Jun-03, Volume: 584, Issue:11 Topics: Glycine max; Glycosyltransferases; Oleanolic Acid; Saponins; Triterpenes	2010
Inhibition of human renin activity by saponins. Biomedical research (Tokyo, Japan), 2010, Volume: 31, Issue:2 Topics: Fruit; Glycine max; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; Oleanolic Acid; Renin; Saponins	2010
[Apoptosis effects on human esophageal cancer cells by soyasaponin Bb and its machanism]. Wei sheng yan jiu = Journal of hygiene research, 2010, Volume: 39, Issue:4 Topics: Apoptosis; Cell Line, Tumor; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Oleanolic Acid; Saponins	2010
Anti-inflammatory effect of soyasaponins through suppressing nitric oxide production in LPS-stimulated RAW 264.7 cells by attenuation of NF-κB-mediated nitric oxide synthase expression. Bioorganic & medicinal chemistry letters, 2011, Apr-15, Volume: 21, Issue:8 Topics: Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Lipopolysaccharides; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Saponins; Tumor Necrosis Factor-alpha	2011
Soyasapogenol B and trans-22-dehydrocam- pesterol from common vetch (Vicia sativa L.) root exudates stimulate broomrape seed germination. Pest management science, 2011, Volume: 67, Issue:8 Topics: Cholestadienols; Germination; Magnetic Resonance Spectroscopy; Molecular Conformation; Oleanolic Acid; Orobanche; Phytosterols; Plant Exudates; Plant Roots; Saponins; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Vicia sativa	2011
Analysis of isoflavone, phenolic, soyasapogenol, and tocopherol compounds in soybean [ Glycine max (L.) Merrill] germplasms of different seed weights and origins. Journal of agricultural and food chemistry, 2012, Jun-13, Volume: 60, Issue:23 Topics: Antioxidants; China; Glycine max; Isoflavones; Oleanolic Acid; Phenols; Republic of Korea; Saponins; Seeds; Tocopherols; United States	2012
Combinatorial biosynthesis of legume natural and rare triterpenoids in engineered yeast. Plant & cell physiology, 2013, Volume: 54, Issue:5 Topics: Biosynthetic Pathways; Gene Expression Regulation, Plant; Genes, Plant; Medicago truncatula; Metabolic Engineering; Oleanolic Acid; Phylogeny; Saccharomyces cerevisiae; Saponins; Triterpenes	2013
Comparison of bioavailability (I) between soyasaponins and soyasapogenols, and (II) between group A and B soyasaponins. Nutrition (Burbank, Los Angeles County, Calif.), 2014, Volume: 30, Issue:5 Topics: Animals; Caco-2 Cells; Humans; Intestinal Absorption; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins	2014
Lactobacillus pentosus var. plantarum C29 increases the protective effect of soybean against scopolamine-induced memory impairment in mice. International journal of food sciences and nutrition, 2015, Volume: 66, Issue:8 Topics: Acetylcholinesterase; Animals; Brain-Derived Neurotrophic Factor; Fermentation; Gene Expression Regulation; Genistein; Glycine max; Hippocampus; Isoflavones; Lactobacillus plantarum; Male; Memory Disorders; Mice; Mice, Inbred ICR; Oleanolic Acid; Plant Preparations; Saponins; Scopolamine	2015
Artefact formation during acid hydrolysis of saponins from Medicago spp. Phytochemistry, 2017, Volume: 138 Topics: Artifacts; Gas Chromatography-Mass Spectrometry; Glycosides; Hydrolysis; Magnetic Resonance Spectroscopy; Medicago; Molecular Structure; Oleanolic Acid; Saponins; Triterpenes	2017
Soyasapogenol B and Genistein Attenuate Lipopolysaccharide-Induced Memory Impairment in Mice by the Modulation of NF-κB-Mediated BDNF Expression. Journal of agricultural and food chemistry, 2017, Aug-16, Volume: 65, Issue:32 Topics: Animals; Brain-Derived Neurotrophic Factor; Fermentation; Genistein; Glycine max; Humans; Lipopolysaccharides; Male; Memory Disorders; Mice; Mice, Inbred ICR; NF-kappa B; Oleanolic Acid; Plant Extracts; Saponins	2017
Endoplasmic reticulum stress triggered by Soyasapogenol B promotes apoptosis and autophagy in colorectal cancer. Life sciences, 2019, Feb-01, Volume: 218 Topics: Animals; Apoptosis; Autophagy; Cell Proliferation; Colorectal Neoplasms; Endoplasmic Reticulum Stress; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Oleanolic Acid; Saponins; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2019
Soyasapogenol B exhibits anti-growth and anti-metastatic activities in clear cell renal cell carcinoma. Naunyn-Schmiedeberg's archives of pharmacology, 2019, Volume: 392, Issue:5 Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Renal Cell; Cell Proliferation; Female; Humans; Kidney; Kidney Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Oleanolic Acid; Phosphotransferases (Alcohol Group Acceptor); Saponins; Tumor Cells, Cultured	2019
Soyasapogenol B Attenuates Laryngeal Carcinoma Progression through Inducing Apoptotic and Autophagic Cell Death. Anatomical record (Hoboken, N.J. : 2007), 2020, Volume: 303, Issue:7 Topics: Antineoplastic Agents; Apoptosis; Autophagic Cell Death; Carcinoma; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Humans; Laryngeal Neoplasms; Oleanolic Acid; Saponins	2020
Biosynthesis of Soyasapogenol B by Engineered Saccharomyces cerevisiae. Applied biochemistry and biotechnology, 2021, Volume: 193, Issue:10 Topics: Fermentation; Oleanolic Acid; Saccharomyces cerevisiae; Saponins	2021
Effects of Triterpene Soyasapogenol B from International journal of molecular sciences, 2022, Jul-27, Volume: 23, Issue:15 Topics: Arachis; Autophagy; Cell Differentiation; Cell Line; Necroptosis; Oleanolic Acid; Osteoblasts; Saponins; Triterpenes	2022
The Fate and Intermediary Metabolism of Soyasapogenol in the Rat. Molecules (Basel, Switzerland), 2022, Dec-29, Volume: 28, Issue:1 Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Liver; Oleanolic Acid; Rats; Tandem Mass Spectrometry	2022