Page last updated: 2024-08-16

sotalol and verapamil

sotalol has been researched along with verapamil in 78 studies

Research

Studies (78)

TimeframeStudies, this research(%)All Research%
pre-199010 (12.82)18.7374
1990's17 (21.79)18.2507
2000's27 (34.62)29.6817
2010's19 (24.36)24.3611
2020's5 (6.41)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Avdeef, A; Tam, KY1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Hess, ME; Levine, NR; Shanfeld, J2
Camm, AJ; Gill, JS; Mehta, D; Ward, DE1
Garthwaite, SM; Hackett, AM; McDonald, SJ; Schneider, P; Schweingruber, F1
Bettini, R; Cozzi, F; Dal Forno, P; Furlanello, F1
Bandyopadhyay, S; Klaunig, JE; Somani, P1
Huang, SK; Marcus, FI1
Coto, H; Hiromasa, S; Kupersmith, J; Li, ZY; Maldonado, C1
Gülker, H; Haverkamp, W; Hindricks, G; Thale, J1
Gautam, CS; Lal, R; Pandhi, P; Sharma, PL1
Roba, J1
Byon, KY; Fleckenstein, A; Grün, G; Kaufmann, R1
Camin, G; Disertori, M; Fiorentini, F; Furlanello, F; Guareneiro, M; Inama, G; Nicasi, L1
Carlsson, B; Drvota, V; Häggblad, J; Sylvén, C1
De Clerck, F; Lu, HR; Remeysen, P1
Hamer, AW; Hunt, VD; Strathmore, N; Vohra, JK1
Benz, I; Kohlhardt, M1
Betz, P; Kalusche, D; Roskamm, H; Stockinger, J1
Chalmers, JP; McRitchie, RJ; Roberts-Thomson, P; Twidale, N1
Lüderitz, B; Manz, M1
Gautam, CS; Pandhi, P; Sharma, PL1
Chang, MS; Chen, SA; Ding, YA; Feng, AN; Kuo, BI; Lee, SH; Tai, CT; Yu, WC1
Koch, HP; Lüderitz, B; Meinertz, T; Patten, M; Sonntag, F1
Breithardt, G; Burschel, G; Engberding, R; Fetsch, T; Koch, HP; Lukl, J; Trappe, HJ; Treese, N1
Chang, MS; Chen, SA; Cheng, JJ; Hung, CR; Kaun, P; Lee, SH; Lin, FY; Yu, WC1
Hauber, J; Rein, JG; Sigel, H1
Bénardeau, A; Ertel, EA; Hondeghem, L; Weissenburger, J1
Cánoves, J; Chorro, FJ; Guerrero, J; López-Merino, V; Mainar, L; Sanchis, J; Such, L1
Dell'Orfano, JT; Luck, JC; Naccarelli, GV; Patel, HM; Wolbrette, DL1
Fetsch, T1
Khan, IA2
Aybek, T; Dzemali, O; Moritz, A; Scherer, M; Wimmer-Greinecker, G1
Sung, RJ1
Blagova, OV; Bogdanova, EA; Nedostup, AV; Platonova, AA1
Bauer, P; Breithardt, G; Engberding, R; Fetsch, T; Koch, HP; Lukl, J; Meinertz, T; Oeff, M; Seipel, L; Trappe, HJ; Treese, N1
Bauer, P; Dluzniewski, M; Hatala, R; Lüderitz, B; Maas, R; Meinertz, T; Müller, HW; Opolski, G; Patten, M; Sonntag, F1
Andreas, JO; Hauser, R; Jahnel, U; Linz, K; Schneider, J1
Antz, M; Kuck, KH; Nitschmann, S1
Ingul, CB; Knapstad, SE; Lien, S; Moen, S; Rygnestad, T; Schrader, H; Wahba, A1
Ho, TB; Leaver, SK1
Hii, JT; Horowitz, JD; Ritchie, RH; Wuttke, RD; Zeitz, CJ1
Cai, Y; Jia, J; Li, S; Liu, G; Liu, Y; Pan, C; Ren, J; Yu, C1
Basso, C; Bobbo, F; Iliceto, S; Maron, BJ; Melacini, P; Thiene, G; Tokajuk, B; Zucchetto, M1
Akie, Y; Nakamura, Y; Sakaguchi, Y; Sugiyama, A; Takahara, A1
Khezheva, FM; Mazur, NA1
Bonnemeier, H; Hescheler, J; Liang, H; Matzkies, M; Reppel, M; Schunkert, H; Tang, M1
Furutani, K; Inanobe, A; Kurachi, Y; Ohno, Y; Yamakawa, Y1
Dosdall, DJ; Huang, J; Ideker, RE; Jin, Q; Li, L; Rogers, JM1
Dosdall, DJ; Huang, J; Ideker, RE; Jin, Q; Li, L; Rogers, JM; Wu, L1
Árpádffy-Lovas, T; Gazdag, P; Geramipour, A; Jost, N; Kohajda, Z; Orvos, P; Szlovák, J; Tálosi, L; Tóth, D; Varró, A; Virág, L1
Hinoi, E; Miyawaki, I; Tsubouchi, T; Watanabe, K; Yamada, T1
Andrews, LM; Koch, BCP; van der Nagel, BCH; van Domburg, B1
Adiyaman, A; Beukema, RJ; de Jong, JSSG; Delnoy, PPHM; Elvan, A; Haanschoten, DM; Khan, M; Otten, AM; Ramdat Misier, AR; Smit, JJJ; Szili-Torok, T; Ter Bekke, RMA; Vernooy, K1
Bai, S; Cao, H; Chen, K; Dong, H; Ma, Y; Pei, J; Tian, L; Zhao, Y1
Bertels, RA; Blom, NA; Filippini, LH; Kammeraad, JAE; Knobbe, I; Kuipers, IM; Zeelenberg, AM1
Goto, A; Izumi-Nakaseko, H; Kambayashi, R; Kanda, Y; Kawai, S; Matsumoto, A; Nunoi, Y; Sakamoto, K; Sugiyama, A; Takei, Y1
Kawai, T; Kuninishi, Y; Muraki, Y; Nogawa, H1

Reviews

8 review(s) available for sotalol and verapamil

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Antiarrhythmic drug therapy of ventricular arrhythmias.
    Current problems in cardiology, 1986, Volume: 11, Issue:4

    Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil

1986
[Long-term drug therapy of reciprocating supraventricular tachycardia: re-examination of a selected series of cases, using computerized programs].
    Bollettino della Societa italiana di cardiologia, 1980, Volume: 25, Issue:10

    Topics: Acebutolol; Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Child; Computers; Digoxin; Humans; Medigoxin; Middle Aged; Oxprenolol; Propafenone; Propiophenones; Sotalol; Tachycardia; Verapamil

1980
Supraventricular tachycardia and pre-excitation syndromes: pharmacological therapy.
    European heart journal, 1993, Volume: 14 Suppl E

    Topics: Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Disopyramide; Flecainide; Humans; Imidazoles; Pre-Excitation Syndromes; Propafenone; Quinidine; Sotalol; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil

1993
Cost-effective management of acute atrial fibrillation: role of rate control, spontaneous conversion, medical and direct current cardioversion, transesophageal echocardiography, and antiembolic therapy.
    The American journal of cardiology, 2000, May-25, Volume: 85, Issue:10A

    Topics: Algorithms; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Cost-Benefit Analysis; Echocardiography, Transesophageal; Electric Countershock; Flecainide; Humans; Procainamide; Propafenone; Quinidine; Sotalol; Verapamil

2000
Transient atrial mechanical dysfunction (stunning) after cardioversion of atrial fibrillation and flutter.
    American heart journal, 2002, Volume: 144, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Appendage; Atrial Fibrillation; Atrial Flutter; Catheter Ablation; Dogs; Electric Countershock; Heart Atria; Humans; Myocardial Contraction; Myocardial Stunning; Phenethylamines; Regional Blood Flow; Sotalol; Sulfonamides; Ultrasonography; Verapamil

2002
Atrial stunning: basics and clinical considerations.
    International journal of cardiology, 2003, Volume: 92, Issue:2-3

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Atrial Function; Atrial Function, Left; Atrial Function, Right; Catheter Ablation; Electric Countershock; Humans; Isoproterenol; Myocardial Stunning; Phenethylamines; Sotalol; Sulfonamides; Thromboembolism; Time Factors; Verapamil

2003
Facilitating electrical cardioversion of persistant atrial fibrillation by antiarrhythmic drugs: update on clinical trial results.
    Cardiac electrophysiology review, 2003, Volume: 7, Issue:3

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Countershock; Humans; Propafenone; Randomized Controlled Trials as Topic; Sotalol; Treatment Outcome; Verapamil

2003

Trials

8 trial(s) available for sotalol and verapamil

ArticleYear
Oral flecainide, sotalol, and verapamil for the termination of paroxysmal supraventricular tachycardia.
    Pacing and clinical electrophysiology : PACE, 1993, Volume: 16, Issue:7 Pt 1

    Topics: Administration, Oral; Adult; Cardiac Pacing, Artificial; Female; Flecainide; Humans; Male; Middle Aged; Sotalol; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil

1993
[Sotalol and quinidine/verapamil (Cordichin) in chronic atrial fibrillation--conversion and 12-month follow-up--a randomized comparison].
    Zeitschrift fur Kardiologie, 1994, Volume: 83 Suppl 5

    Topics: Aged; Atrial Fibrillation; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Electric Countershock; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Humans; Long-Term Care; Male; Middle Aged; Quinidine; Sotalol; Verapamil

1994
Tachycardia-induced change of atrial refractory period in humans: rate dependency and effects of antiarrhythmic drugs.
    Circulation, 1998, Jun-16, Volume: 97, Issue:23

    Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Electrophysiology; Female; Humans; Male; Middle Aged; Pacemaker, Artificial; Procainamide; Propafenone; Propranolol; Sotalol; Tachycardia, Supraventricular; Verapamil

1998
[Medicamentous prevention of symptomatic paroxysmal atrial fibrillation/flutter onset. Goals and design of the SOPAT Study. Executive committee of the investigators representing trial physicians].
    Zeitschrift fur Kardiologie, 1999, Volume: 88, Issue:3

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Electric Countershock; Electrocardiography, Ambulatory; Germany; Humans; Prospective Studies; Quinidine; Recurrence; Sotalol; Tachycardia, Paroxysmal; Telemetry; Treatment Outcome; Verapamil

1999
[Medicamentous prevention after electric cardioversion of chronic atrial fibrillation. Goals and design of the PAFAC Study].
    Zeitschrift fur Kardiologie, 1999, Volume: 88, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Chronic Disease; Czech Republic; Double-Blind Method; Drug Combinations; Electric Countershock; Electrocardiography, Ambulatory; Female; Germany; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Sotalol; Telemetry; Verapamil

1999
Prevention of atrial fibrillation after cardioversion: results of the PAFAC trial.
    European heart journal, 2004, Volume: 25, Issue:16

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Double-Blind Method; Drug Therapy, Combination; Electric Countershock; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Secondary Prevention; Sotalol; Survival Analysis; Treatment Outcome; Verapamil

2004
Suppression of paroxysmal atrial tachyarrhythmias--results of the SOPAT trial.
    European heart journal, 2004, Volume: 25, Issue:16

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Drug Therapy, Combination; Electrocardiography; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Sotalol; Survival Analysis; Tachycardia; Treatment Outcome; Verapamil

2004
Elimination of Benign Ventricular Premature Beats or Ventricular Tachycardia with Catheter Ablation versus Two Different Optimal Antiarrhythmic Drug Treatment Regimens (Sotalol or Verapamil/Flecainide).
    Cardiology, 2020, Volume: 145, Issue:12

    Topics: Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Catheter Ablation; Flecainide; Humans; Prospective Studies; Quality of Life; Sotalol; Tachycardia, Ventricular; Treatment Outcome; Verapamil

2020

Other Studies

62 other study(ies) available for sotalol and verapamil

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

    Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers

2012
MICE models: superior to the HERG model in predicting Torsade de Pointes.
    Scientific reports, 2013, Volume: 3

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Effects of verapamil on myocardial contractility, cardiac adenosine 3,'5'-monophosphate and heart phosphorylase.
    The Journal of pharmacology and experimental therapeutics, 1975, Volume: 193, Issue:2

    Topics: Animals; Calcium; Cyclic AMP; In Vitro Techniques; Isoproterenol; Male; Mephentermine; Methoxamine; Myocardial Contraction; Myocardium; Phosphorylases; Rats; Sotalol; Verapamil

1975
Metabolic and inotropic effects of verapamil in perfused rat heart.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 10

    Topics: Animals; Calcium; Cyclic AMP; Depression, Chemical; Isoproterenol; Mephentermine; Methoxamine; Myocardial Contraction; Myocardium; Perfusion; Phosphorylases; Rats; Sotalol; Verapamil

1975
Efficacy of flecainide, sotalol, and verapamil in the treatment of right ventricular tachycardia in patients without overt cardiac abnormality.
    British heart journal, 1992, Volume: 68, Issue:4

    Topics: Adult; Aged; Electric Stimulation; Exercise Test; Flecainide; Humans; Male; Middle Aged; Sotalol; Tachycardia, Ventricular; Treatment Outcome; Verapamil

1992
Simple in vitro method to characterize antiarrhythmic agents.
    Journal of pharmacological methods, 1990, Volume: 23, Issue:2

    Topics: Acecainide; Animals; Anti-Arrhythmia Agents; Disopyramide; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Papillary Muscles; Quaternary Ammonium Compounds; Refractory Period, Electrophysiological; Sotalol; Verapamil

1990
Arrhythmogenic effects of antiarrhythmic drugs.
    Cardiologia (Rome, Italy), 1990, Volume: 35, Issue:1 Suppl

    Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Female; Flecainide; Humans; Male; Middle Aged; Propafenone; Risk Factors; Sotalol; Tachycardia; Verapamil

1990
Cytotoxic interactions of cardioactive cationic amphiphilic compounds in primary rat hepatocytes in culture.
    Hepatology (Baltimore, Md.), 1990, Volume: 12, Issue:1

    Topics: Amiodarone; Animals; Atenolol; Biomarkers; Cardiotonic Agents; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; L-Lactate Dehydrogenase; Liver; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Procainamide; Propranolol; Rats; Rats, Inbred Strains; Sotalol; Verapamil

1990
Dextrorotatory isomer of sotalol: electrophysiologic effects and interaction with verapamil.
    American heart journal, 1988, Volume: 116, Issue:6 Pt 1

    Topics: Action Potentials; Animals; Heart Conduction System; In Vitro Techniques; Membrane Potentials; Purkinje Fibers; Sheep; Sotalol; Stereoisomerism; Time Factors; Verapamil

1988
Comparative investigations on the antiarrhythmic and electrophysiologic effects of class I-IV antiarrhythmic agents following acute coronary artery occlusion.
    European heart journal, 1987, Volume: 8 Suppl G

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Dogs; Female; Heart Conduction System; Lidocaine; Male; Metoprolol; Myocardial Infarction; Sotalol; Ventricular Fibrillation; Verapamil

1987
Differential effect of some antiarrhythmic drugs in right- or left-sided aconitine-induced experimental atrial arrhythmias.
    Methods and findings in experimental and clinical pharmacology, 1987, Volume: 9, Issue:2

    Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Dogs; Female; Male; Propranolol; Quinidine; Sotalol; Verapamil

1987
Cardiac toxicity of -lytic drugs.
    Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 196

    Topics: 1-Propanol; Acetanilides; Adrenergic beta-Antagonists; Alprenolol; Amino Alcohols; Animals; Cresols; Ethanolamines; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Indoles; Muscle Contraction; Nitrobenzenes; Oxprenolol; Papaverine; Phenethylamines; Prenylamine; Propranolol; Propylamines; Sotalol; Sympatholytics; Verapamil

1972
[Differentiation between beta adrenergic and Ca 2+ antagonistic influencing components of beta receptor blockaders in the myocardium and in smooth muscles with special reference to Trasicor].
    Arztliche Forschung, 1972, Nov-10, Volume: 26, Issue:11

    Topics: Adrenergic beta-Antagonists; Allyl Compounds; Amino Alcohols; Animals; Calcium; Cats; Chick Embryo; Female; Guinea Pigs; Heart; Muscle Contraction; Muscle, Smooth; Papillary Muscles; Pindolol; Potassium; Prenylamine; Propranolol; Propylamines; Rabbits; Rats; Sotalol; Uterus; Verapamil

1972
Amiodarone is a dose-dependent noncompetitive and competitive inhibitor of T3 binding to thyroid hormone receptor subtype beta 1, whereas disopyramide, lignocaine, propafenone, metoprolol, dl-sotalol, and verapamil have no inhibitory effect.
    Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:2

    Topics: Amiodarone; Anti-Arrhythmia Agents; Binding, Competitive; Disopyramide; Dose-Response Relationship, Drug; Humans; Lidocaine; Metoprolol; Propafenone; Receptors, Thyroid Hormone; Sotalol; Triiodothyronine; Verapamil

1995
Antifibrillary action of class I-IV antiarrhythmic agents in the model of ventricular fibrillation threshold of anesthetized guinea pigs.
    Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Atenolol; Benzopyrans; Chromans; Disease Models, Animal; Electric Stimulation; Electrocardiography; Encainide; Ethanolamines; Guinea Pigs; Heart; Heart Conduction System; Injections, Intravenous; Male; Metoprolol; Nebivolol; Phenethylamines; Piperidines; Sotalol; Sulfonamides; Ventricular Fibrillation; Verapamil

1995
Distinct modes of blockade in cardiac ATP-sensitive K+ channels suggest multiple targets for inhibitory drug molecules.
    The Journal of membrane biology, 1994, Volume: 142, Issue:3

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Binding Sites; Cells, Cultured; Glyburide; Imidazoles; Kinetics; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Propanolamines; Rats; Sotalol; Verapamil

1994
Comparative haemodynamic effects of verapamil, flecainide, amiodarone and sotalol in the conscious rabbit.
    Clinical and experimental pharmacology & physiology, 1994, Volume: 21, Issue:3

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Function; Autonomic Nerve Block; Autonomic Nervous System; Cardiac Output; Cardiac Pacing, Artificial; Consciousness; Flecainide; Heart; Heart Atria; Heart Rate; Hemodynamics; Male; Rabbits; Sotalol; Verapamil

1994
Differential effect of selected antiarrhythmic drugs on coronary artery ligation-induced ventricular arrhythmias on the right or left sides.
    Methods and findings in experimental and clinical pharmacology, 1995, Volume: 17, Issue:5

    Topics: Animals; Anti-Arrhythmia Agents; Coronary Disease; Disease Models, Animal; Dogs; Female; Ligation; Male; Propranolol; Quinidine; Sotalol; Tachycardia, Ventricular; Verapamil

1995
Change of atrial refractory period after short duration of rapid atrial pacing: regional differences and possible mechanisms.
    Pacing and clinical electrophysiology : PACE, 1999, Volume: 22, Issue:6 Pt 1

    Topics: Adenosine Triphosphatases; Animals; Anti-Arrhythmia Agents; Atrial Function; Calcium Channels; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Heart Rate; Nicorandil; Potassium Channels; Premedication; Ryanodine; Sotalol; Verapamil

1999
[Transitory left ventricular outflow tract obstruction after mitral valve reconstruction].
    Deutsche medizinische Wochenschrift (1946), 1999, Sep-24, Volume: 124, Issue:38

    Topics: Adrenergic beta-Antagonists; Adult; Echocardiography; Follow-Up Studies; Heart Valve Prosthesis Implantation; Humans; Male; Mitral Valve; Mitral Valve Insufficiency; Mitral Valve Prolapse; Pericardial Effusion; Sotalol; Time Factors; Vasodilator Agents; Ventricular Outflow Obstruction; Verapamil

1999
Effects of the T-type Ca(2+) channel blocker mibefradil on repolarization of guinea pig, rabbit, dog, monkey, and human cardiac tissue.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:2

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Diltiazem; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Female; Guinea Pigs; Heart; Heart Atria; Humans; In Vitro Techniques; Male; Mibefradil; Rabbits; Saimiri; Sotalol; Telemetry; Time Factors; Verapamil

2000
Alteration of ventricular fibrillation by flecainide, verapamil, and sotalol: an experimental study.
    Circulation, 2000, Apr-04, Volume: 101, Issue:13

    Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Electrophysiology; Flecainide; Heart Conduction System; Rabbits; Refractory Period, Electrophysiological; Sotalol; Ventricular Fibrillation; Verapamil

2000
[Atrial fibrillation successfully converted. A new standard in the prevention of recurrence?].
    MMW Fortschritte der Medizin, 2001, Dec-13, Volume: 143, Issue:51-52

    Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Calcium Channel Blockers; Chronic Disease; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Humans; Placebos; Quinidine; Randomized Controlled Trials as Topic; Recurrence; Sotalol; Time Factors; Verapamil

2001
Impact of left atrial size reduction on chronic atrial fibrillation in mitral valve surgery.
    The Journal of heart valve disease, 2003, Volume: 12, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Pacing, Artificial; Cardiopulmonary Bypass; Chronic Disease; Cohort Studies; Digitoxin; Echocardiography; Electric Countershock; Female; Follow-Up Studies; Heart Atria; Heart Conduction System; Heart Valve Diseases; Humans; Male; Middle Aged; Mitral Valve; Postoperative Complications; Sotalol; Survival Analysis; Treatment Outcome; Verapamil

2003
[Correction of rate and structure of ventricular rhythm in permanent atrial fibrillation: a novel pathogenetic approach].
    Kardiologiia, 2004, Volume: 44, Issue:1

    Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Digoxin; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Periodicity; Sotalol; Ventricular Premature Complexes; Verapamil

2004
Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs.
    European journal of pharmacology, 2005, Apr-04, Volume: 512, Issue:1

    Topics: Animals; Calcium Channel Blockers; Dogs; Electrocardiography; Ether-A-Go-Go Potassium Channels; Humans; Male; Phenethylamines; Potassium Channels; Sotalol; Sulfonamides; Torsades de Pointes; Verapamil

2005
[PAFAC Study. Secondary prevention of atrial fibrillation after cardioversion].
    Der Internist, 2005, Volume: 46, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Therapy, Combination; Electric Countershock; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Secondary Prevention; Sotalol; Survival Analysis; Treatment Outcome; Verapamil

2005
Severe poisoning with sotalol and verapamil. Recovery after 4 h of normothermic CPR followed by extra corporeal heart lung assist.
    Acta anaesthesiologica Scandinavica, 2005, Volume: 49, Issue:9

    Topics: Adrenergic beta-Antagonists; Adult; Calcium Channel Blockers; Cardiopulmonary Resuscitation; Female; Heart Arrest; Heart-Assist Devices; Humans; Respiration, Artificial; Sotalol; Suicide, Attempted; Verapamil

2005
Inadvertent toxic drug reaction in the management of atrial fibrillation.
    Journal of the Royal Society of Medicine, 2006, Volume: 99, Issue:3

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Digoxin; Drug Interactions; Electrocardiography; Female; Humans; Hypotension; Middle Aged; Sotalol; Time Factors; Verapamil

2006
Attenuation of the negative inotropic effects of metoprolol at short cycle lengths in humans: comparison with sotalol and verapamil.
    Journal of the American College of Cardiology, 2006, Sep-19, Volume: 48, Issue:6

    Topics: Aged; Anti-Arrhythmia Agents; Cardiac Catheterization; Cardiac Pacing, Artificial; Female; Hemodynamics; Humans; Male; Metoprolol; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Pressure; Sotalol; Systole; Time Factors; Ventricular Function, Left; Verapamil

2006
Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Mar-01, Volume: 847, Issue:2

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carbazoles; Carvedilol; Chromatography, Liquid; Diltiazem; Humans; Metoprolol; Mexiletine; Molecular Structure; Propanolamines; Propranolol; Reproducibility of Results; Sotalol; Tandem Mass Spectrometry; Verapamil

2007
Evidence that pharmacological strategies lack efficacy for the prevention of sudden death in hypertrophic cardiomyopathy.
    Heart (British Cardiac Society), 2007, Volume: 93, Issue:6

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathy, Hypertrophic; Child; Child, Preschool; Death, Sudden, Cardiac; Female; Humans; Infant; Kaplan-Meier Estimate; Male; Middle Aged; Retrospective Studies; Sotalol; Verapamil

2007
Halothane-anaesthetized, closed-chest, guinea-pig model for assessment of drug-induced QT-interval prolongation.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 104, Issue:1

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Electrocardiography; Guinea Pigs; Halothane; Heart; Heart Rate; Long QT Syndrome; Male; Models, Animal; Sotalol; Verapamil

2009
[Effect of hypotensive therapy on metalloproteinase activity of the blood in patients with arterial hypertension].
    Kardiologiia, 2009, Volume: 49, Issue:2

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Enzyme-Linked Immunosorbent Assay; Female; Fibrosis; Follow-Up Studies; Heart Diseases; Humans; Hypertension; Male; Matrix Metalloproteinase 1; Middle Aged; Myocardium; Sotalol; Tissue Inhibitor of Metalloproteinase-1; Treatment Outcome; Vasodilator Agents; Verapamil

2009
Human and murine embryonic stem cell-derived cardiomyocytes serve together as a valuable model for drug safety screening.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2010, Volume: 25, Issue:4-5

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Embryonic Stem Cells; Humans; Mice; Myocytes, Cardiac; Quinidine; Sotalol; Verapamil

2010
Pharmacophore modeling for hERG channel facilitation.
    Biochemical and biophysical research communications, 2012, Feb-03, Volume: 418, Issue:1

    Topics: Animals; Atenolol; Chlorpheniramine; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluoxetine; Haloperidol; Humans; Hydrophobic and Hydrophilic Interactions; Imipramine; Metoprolol; Nortriptyline; Potassium Channel Blockers; Promethazine; Propranolol; Quantitative Structure-Activity Relationship; Sotalol; Terfenadine; Verapamil; Xenopus laevis

2012
Verapamil reduces incidence of reentry during ventricular fibrillation in pigs.
    American journal of physiology. Heart and circulatory physiology, 2014, Nov-01, Volume: 307, Issue:9

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Heart Rate; Heart Ventricles; Sotalol; Swine; Ventricular Fibrillation; Ventricular Function; Verapamil

2014
Effects of combination of sotalol and verapamil on initiation, maintenance, and termination of ventricular fibrillation in swine hearts.
    Cardiovascular therapeutics, 2018, Volume: 36, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Cardiac Pacing, Artificial; Drug Synergism; Heart; Heart Conduction System; Infusions, Intravenous; Refractory Period, Electrophysiological; Sotalol; Sus scrofa; Swine; Ventricular Fibrillation; Verapamil

2018
Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 04-01, Volume: 168, Issue:2

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Drug Evaluation, Preclinical; ERG1 Potassium Channel; Female; Heart Ventricles; Humans; Ion Channels; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Rabbits; Sotalol; Sulfonamides; Terfenadine; Tissue Donors; Verapamil

2019
Telemetered common marmosets is useful for the assessment of electrocardiogram parameters changes induced by multiple cardiac ion channel inhibitors.
    The Journal of toxicological sciences, 2019, Volume: 44, Issue:7

    Topics: Animals; Astemizole; Body Temperature; Calcium Channel Blockers; Callithrix; Electrocardiography; Flecainide; Male; Models, Animal; Quinidine; Risk Assessment; Sotalol; Telemetry; Terfenadine; Verapamil; Voltage-Gated Sodium Channel Blockers

2019
High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2019, Oct-15, Volume: 1129

    Topics: Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carvedilol; Chromatography, High Pressure Liquid; Diltiazem; Flecainide; High-Throughput Screening Assays; Humans; Lidocaine; Metoprolol; Propranolol; Reproducibility of Results; Sotalol; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Verapamil

2019
Assessment of Drug Proarrhythmic Potential in Electrically Paced Human Induced Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Using Multielectrode Array.
    SLAS discovery : advancing life sciences R & D, 2021, Volume: 26, Issue:3

    Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cations, Divalent; Cell Differentiation; Humans; Induced Pluripotent Stem Cells; Ion Transport; Microelectrodes; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Nifedipine; Patch-Clamp Techniques; Phenethylamines; Primary Cell Culture; Quinidine; Sotalol; Sulfonamides; Tetrodotoxin; Verapamil

2021
The Efficacy of Anti-Arrhythmic Drugs in Children With Idiopathic Frequent Symptomatic or Asymptomatic Premature Ventricular Complexes With or Without Asymptomatic Ventricular Tachycardia: a Retrospective Multi-Center Study.
    Pediatric cardiology, 2021, Volume: 42, Issue:4

    Topics: Adolescent; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Child; Child, Preschool; Female; Flecainide; Humans; Male; Retrospective Studies; Sotalol; Tachycardia, Ventricular; Treatment Outcome; Ventricular Premature Complexes; Verapamil

2021
Torsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Silico Mechanistic Model.
    Toxicological sciences : an official journal of the Society of Toxicology, 2021, 04-27, Volume: 181, Issue:1

    Topics: Animals; Atrioventricular Block; Bepridil; Cisapride; Computer Simulation; Macaca fascicularis; Sotalol; Torsades de Pointes; Verapamil

2021
Pharmacological characterisation of electrocardiogram J-T
    European journal of pharmacology, 2022, Jul-15, Volume: 927

    Topics: Animals; DNA-Binding Proteins; Electrocardiography; Flecainide; Guinea Pigs; Long QT Syndrome; Nifedipine; Quinidine; Quinine; Ranolazine; Sotalol; Torsades de Pointes; Verapamil

2022