sotalol has been researched along with verapamil in 78 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (12.82) | 18.7374 |
| 1990's | 17 (21.79) | 18.2507 |
| 2000's | 27 (34.62) | 29.6817 |
| 2010's | 19 (24.36) | 24.3611 |
| 2020's | 5 (6.41) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Avdeef, A; Tam, KY | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Hess, ME; Levine, NR; Shanfeld, J | 2 |
| Camm, AJ; Gill, JS; Mehta, D; Ward, DE | 1 |
| Garthwaite, SM; Hackett, AM; McDonald, SJ; Schneider, P; Schweingruber, F | 1 |
| Bettini, R; Cozzi, F; Dal Forno, P; Furlanello, F | 1 |
| Bandyopadhyay, S; Klaunig, JE; Somani, P | 1 |
| Huang, SK; Marcus, FI | 1 |
| Coto, H; Hiromasa, S; Kupersmith, J; Li, ZY; Maldonado, C | 1 |
| Gülker, H; Haverkamp, W; Hindricks, G; Thale, J | 1 |
| Gautam, CS; Lal, R; Pandhi, P; Sharma, PL | 1 |
| Roba, J | 1 |
| Byon, KY; Fleckenstein, A; Grün, G; Kaufmann, R | 1 |
| Camin, G; Disertori, M; Fiorentini, F; Furlanello, F; Guareneiro, M; Inama, G; Nicasi, L | 1 |
| Carlsson, B; Drvota, V; Häggblad, J; Sylvén, C | 1 |
| De Clerck, F; Lu, HR; Remeysen, P | 1 |
| Hamer, AW; Hunt, VD; Strathmore, N; Vohra, JK | 1 |
| Benz, I; Kohlhardt, M | 1 |
| Betz, P; Kalusche, D; Roskamm, H; Stockinger, J | 1 |
| Chalmers, JP; McRitchie, RJ; Roberts-Thomson, P; Twidale, N | 1 |
| Lüderitz, B; Manz, M | 1 |
| Gautam, CS; Pandhi, P; Sharma, PL | 1 |
| Chang, MS; Chen, SA; Ding, YA; Feng, AN; Kuo, BI; Lee, SH; Tai, CT; Yu, WC | 1 |
| Koch, HP; Lüderitz, B; Meinertz, T; Patten, M; Sonntag, F | 1 |
| Breithardt, G; Burschel, G; Engberding, R; Fetsch, T; Koch, HP; Lukl, J; Trappe, HJ; Treese, N | 1 |
| Chang, MS; Chen, SA; Cheng, JJ; Hung, CR; Kaun, P; Lee, SH; Lin, FY; Yu, WC | 1 |
| Hauber, J; Rein, JG; Sigel, H | 1 |
| Bénardeau, A; Ertel, EA; Hondeghem, L; Weissenburger, J | 1 |
| Cánoves, J; Chorro, FJ; Guerrero, J; López-Merino, V; Mainar, L; Sanchis, J; Such, L | 1 |
| Dell'Orfano, JT; Luck, JC; Naccarelli, GV; Patel, HM; Wolbrette, DL | 1 |
| Fetsch, T | 1 |
| Khan, IA | 2 |
| Aybek, T; Dzemali, O; Moritz, A; Scherer, M; Wimmer-Greinecker, G | 1 |
| Sung, RJ | 1 |
| Blagova, OV; Bogdanova, EA; Nedostup, AV; Platonova, AA | 1 |
| Bauer, P; Breithardt, G; Engberding, R; Fetsch, T; Koch, HP; Lukl, J; Meinertz, T; Oeff, M; Seipel, L; Trappe, HJ; Treese, N | 1 |
| Bauer, P; Dluzniewski, M; Hatala, R; Lüderitz, B; Maas, R; Meinertz, T; Müller, HW; Opolski, G; Patten, M; Sonntag, F | 1 |
| Andreas, JO; Hauser, R; Jahnel, U; Linz, K; Schneider, J | 1 |
| Antz, M; Kuck, KH; Nitschmann, S | 1 |
| Ingul, CB; Knapstad, SE; Lien, S; Moen, S; Rygnestad, T; Schrader, H; Wahba, A | 1 |
| Ho, TB; Leaver, SK | 1 |
| Hii, JT; Horowitz, JD; Ritchie, RH; Wuttke, RD; Zeitz, CJ | 1 |
| Cai, Y; Jia, J; Li, S; Liu, G; Liu, Y; Pan, C; Ren, J; Yu, C | 1 |
| Basso, C; Bobbo, F; Iliceto, S; Maron, BJ; Melacini, P; Thiene, G; Tokajuk, B; Zucchetto, M | 1 |
| Akie, Y; Nakamura, Y; Sakaguchi, Y; Sugiyama, A; Takahara, A | 1 |
| Khezheva, FM; Mazur, NA | 1 |
| Bonnemeier, H; Hescheler, J; Liang, H; Matzkies, M; Reppel, M; Schunkert, H; Tang, M | 1 |
| Furutani, K; Inanobe, A; Kurachi, Y; Ohno, Y; Yamakawa, Y | 1 |
| Dosdall, DJ; Huang, J; Ideker, RE; Jin, Q; Li, L; Rogers, JM | 1 |
| Dosdall, DJ; Huang, J; Ideker, RE; Jin, Q; Li, L; Rogers, JM; Wu, L | 1 |
| Árpádffy-Lovas, T; Gazdag, P; Geramipour, A; Jost, N; Kohajda, Z; Orvos, P; Szlovák, J; Tálosi, L; Tóth, D; Varró, A; Virág, L | 1 |
| Hinoi, E; Miyawaki, I; Tsubouchi, T; Watanabe, K; Yamada, T | 1 |
| Andrews, LM; Koch, BCP; van der Nagel, BCH; van Domburg, B | 1 |
| Adiyaman, A; Beukema, RJ; de Jong, JSSG; Delnoy, PPHM; Elvan, A; Haanschoten, DM; Khan, M; Otten, AM; Ramdat Misier, AR; Smit, JJJ; Szili-Torok, T; Ter Bekke, RMA; Vernooy, K | 1 |
| Bai, S; Cao, H; Chen, K; Dong, H; Ma, Y; Pei, J; Tian, L; Zhao, Y | 1 |
| Bertels, RA; Blom, NA; Filippini, LH; Kammeraad, JAE; Knobbe, I; Kuipers, IM; Zeelenberg, AM | 1 |
| Goto, A; Izumi-Nakaseko, H; Kambayashi, R; Kanda, Y; Kawai, S; Matsumoto, A; Nunoi, Y; Sakamoto, K; Sugiyama, A; Takei, Y | 1 |
| Kawai, T; Kuninishi, Y; Muraki, Y; Nogawa, H | 1 |
8 review(s) available for sotalol and verapamil
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Antiarrhythmic drug therapy of ventricular arrhythmias.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil | 1986 |
[Long-term drug therapy of reciprocating supraventricular tachycardia: re-examination of a selected series of cases, using computerized programs].
Topics: Acebutolol; Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Child; Computers; Digoxin; Humans; Medigoxin; Middle Aged; Oxprenolol; Propafenone; Propiophenones; Sotalol; Tachycardia; Verapamil | 1980 |
Supraventricular tachycardia and pre-excitation syndromes: pharmacological therapy.
Topics: Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Disopyramide; Flecainide; Humans; Imidazoles; Pre-Excitation Syndromes; Propafenone; Quinidine; Sotalol; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil | 1993 |
Cost-effective management of acute atrial fibrillation: role of rate control, spontaneous conversion, medical and direct current cardioversion, transesophageal echocardiography, and antiembolic therapy.
Topics: Algorithms; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Cost-Benefit Analysis; Echocardiography, Transesophageal; Electric Countershock; Flecainide; Humans; Procainamide; Propafenone; Quinidine; Sotalol; Verapamil | 2000 |
Transient atrial mechanical dysfunction (stunning) after cardioversion of atrial fibrillation and flutter.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Appendage; Atrial Fibrillation; Atrial Flutter; Catheter Ablation; Dogs; Electric Countershock; Heart Atria; Humans; Myocardial Contraction; Myocardial Stunning; Phenethylamines; Regional Blood Flow; Sotalol; Sulfonamides; Ultrasonography; Verapamil | 2002 |
Atrial stunning: basics and clinical considerations.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Atrial Function; Atrial Function, Left; Atrial Function, Right; Catheter Ablation; Electric Countershock; Humans; Isoproterenol; Myocardial Stunning; Phenethylamines; Sotalol; Sulfonamides; Thromboembolism; Time Factors; Verapamil | 2003 |
Facilitating electrical cardioversion of persistant atrial fibrillation by antiarrhythmic drugs: update on clinical trial results.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Countershock; Humans; Propafenone; Randomized Controlled Trials as Topic; Sotalol; Treatment Outcome; Verapamil | 2003 |
8 trial(s) available for sotalol and verapamil
| Article | Year |
|---|---|
Oral flecainide, sotalol, and verapamil for the termination of paroxysmal supraventricular tachycardia.
Topics: Administration, Oral; Adult; Cardiac Pacing, Artificial; Female; Flecainide; Humans; Male; Middle Aged; Sotalol; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil | 1993 |
[Sotalol and quinidine/verapamil (Cordichin) in chronic atrial fibrillation--conversion and 12-month follow-up--a randomized comparison].
Topics: Aged; Atrial Fibrillation; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Electric Countershock; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Humans; Long-Term Care; Male; Middle Aged; Quinidine; Sotalol; Verapamil | 1994 |
Tachycardia-induced change of atrial refractory period in humans: rate dependency and effects of antiarrhythmic drugs.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Electrophysiology; Female; Humans; Male; Middle Aged; Pacemaker, Artificial; Procainamide; Propafenone; Propranolol; Sotalol; Tachycardia, Supraventricular; Verapamil | 1998 |
[Medicamentous prevention of symptomatic paroxysmal atrial fibrillation/flutter onset. Goals and design of the SOPAT Study. Executive committee of the investigators representing trial physicians].
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Electric Countershock; Electrocardiography, Ambulatory; Germany; Humans; Prospective Studies; Quinidine; Recurrence; Sotalol; Tachycardia, Paroxysmal; Telemetry; Treatment Outcome; Verapamil | 1999 |
[Medicamentous prevention after electric cardioversion of chronic atrial fibrillation. Goals and design of the PAFAC Study].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Chronic Disease; Czech Republic; Double-Blind Method; Drug Combinations; Electric Countershock; Electrocardiography, Ambulatory; Female; Germany; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Sotalol; Telemetry; Verapamil | 1999 |
Prevention of atrial fibrillation after cardioversion: results of the PAFAC trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Double-Blind Method; Drug Therapy, Combination; Electric Countershock; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Secondary Prevention; Sotalol; Survival Analysis; Treatment Outcome; Verapamil | 2004 |
Suppression of paroxysmal atrial tachyarrhythmias--results of the SOPAT trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Drug Therapy, Combination; Electrocardiography; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Sotalol; Survival Analysis; Tachycardia; Treatment Outcome; Verapamil | 2004 |
Elimination of Benign Ventricular Premature Beats or Ventricular Tachycardia with Catheter Ablation versus Two Different Optimal Antiarrhythmic Drug Treatment Regimens (Sotalol or Verapamil/Flecainide).
Topics: Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Catheter Ablation; Flecainide; Humans; Prospective Studies; Quality of Life; Sotalol; Tachycardia, Ventricular; Treatment Outcome; Verapamil | 2020 |
62 other study(ies) available for sotalol and verapamil
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Effects of verapamil on myocardial contractility, cardiac adenosine 3,'5'-monophosphate and heart phosphorylase.
Topics: Animals; Calcium; Cyclic AMP; In Vitro Techniques; Isoproterenol; Male; Mephentermine; Methoxamine; Myocardial Contraction; Myocardium; Phosphorylases; Rats; Sotalol; Verapamil | 1975 |
Metabolic and inotropic effects of verapamil in perfused rat heart.
Topics: Animals; Calcium; Cyclic AMP; Depression, Chemical; Isoproterenol; Mephentermine; Methoxamine; Myocardial Contraction; Myocardium; Perfusion; Phosphorylases; Rats; Sotalol; Verapamil | 1975 |
Efficacy of flecainide, sotalol, and verapamil in the treatment of right ventricular tachycardia in patients without overt cardiac abnormality.
Topics: Adult; Aged; Electric Stimulation; Exercise Test; Flecainide; Humans; Male; Middle Aged; Sotalol; Tachycardia, Ventricular; Treatment Outcome; Verapamil | 1992 |
Simple in vitro method to characterize antiarrhythmic agents.
Topics: Acecainide; Animals; Anti-Arrhythmia Agents; Disopyramide; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Papillary Muscles; Quaternary Ammonium Compounds; Refractory Period, Electrophysiological; Sotalol; Verapamil | 1990 |
Arrhythmogenic effects of antiarrhythmic drugs.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Female; Flecainide; Humans; Male; Middle Aged; Propafenone; Risk Factors; Sotalol; Tachycardia; Verapamil | 1990 |
Cytotoxic interactions of cardioactive cationic amphiphilic compounds in primary rat hepatocytes in culture.
Topics: Amiodarone; Animals; Atenolol; Biomarkers; Cardiotonic Agents; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; L-Lactate Dehydrogenase; Liver; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Procainamide; Propranolol; Rats; Rats, Inbred Strains; Sotalol; Verapamil | 1990 |
Dextrorotatory isomer of sotalol: electrophysiologic effects and interaction with verapamil.
Topics: Action Potentials; Animals; Heart Conduction System; In Vitro Techniques; Membrane Potentials; Purkinje Fibers; Sheep; Sotalol; Stereoisomerism; Time Factors; Verapamil | 1988 |
Comparative investigations on the antiarrhythmic and electrophysiologic effects of class I-IV antiarrhythmic agents following acute coronary artery occlusion.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Dogs; Female; Heart Conduction System; Lidocaine; Male; Metoprolol; Myocardial Infarction; Sotalol; Ventricular Fibrillation; Verapamil | 1987 |
Differential effect of some antiarrhythmic drugs in right- or left-sided aconitine-induced experimental atrial arrhythmias.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Dogs; Female; Male; Propranolol; Quinidine; Sotalol; Verapamil | 1987 |
Cardiac toxicity of -lytic drugs.
Topics: 1-Propanol; Acetanilides; Adrenergic beta-Antagonists; Alprenolol; Amino Alcohols; Animals; Cresols; Ethanolamines; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Indoles; Muscle Contraction; Nitrobenzenes; Oxprenolol; Papaverine; Phenethylamines; Prenylamine; Propranolol; Propylamines; Sotalol; Sympatholytics; Verapamil | 1972 |
[Differentiation between beta adrenergic and Ca 2+ antagonistic influencing components of beta receptor blockaders in the myocardium and in smooth muscles with special reference to Trasicor].
Topics: Adrenergic beta-Antagonists; Allyl Compounds; Amino Alcohols; Animals; Calcium; Cats; Chick Embryo; Female; Guinea Pigs; Heart; Muscle Contraction; Muscle, Smooth; Papillary Muscles; Pindolol; Potassium; Prenylamine; Propranolol; Propylamines; Rabbits; Rats; Sotalol; Uterus; Verapamil | 1972 |
Amiodarone is a dose-dependent noncompetitive and competitive inhibitor of T3 binding to thyroid hormone receptor subtype beta 1, whereas disopyramide, lignocaine, propafenone, metoprolol, dl-sotalol, and verapamil have no inhibitory effect.
Topics: Amiodarone; Anti-Arrhythmia Agents; Binding, Competitive; Disopyramide; Dose-Response Relationship, Drug; Humans; Lidocaine; Metoprolol; Propafenone; Receptors, Thyroid Hormone; Sotalol; Triiodothyronine; Verapamil | 1995 |
Antifibrillary action of class I-IV antiarrhythmic agents in the model of ventricular fibrillation threshold of anesthetized guinea pigs.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Atenolol; Benzopyrans; Chromans; Disease Models, Animal; Electric Stimulation; Electrocardiography; Encainide; Ethanolamines; Guinea Pigs; Heart; Heart Conduction System; Injections, Intravenous; Male; Metoprolol; Nebivolol; Phenethylamines; Piperidines; Sotalol; Sulfonamides; Ventricular Fibrillation; Verapamil | 1995 |
Distinct modes of blockade in cardiac ATP-sensitive K+ channels suggest multiple targets for inhibitory drug molecules.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Binding Sites; Cells, Cultured; Glyburide; Imidazoles; Kinetics; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Propanolamines; Rats; Sotalol; Verapamil | 1994 |
Comparative haemodynamic effects of verapamil, flecainide, amiodarone and sotalol in the conscious rabbit.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Function; Autonomic Nerve Block; Autonomic Nervous System; Cardiac Output; Cardiac Pacing, Artificial; Consciousness; Flecainide; Heart; Heart Atria; Heart Rate; Hemodynamics; Male; Rabbits; Sotalol; Verapamil | 1994 |
Differential effect of selected antiarrhythmic drugs on coronary artery ligation-induced ventricular arrhythmias on the right or left sides.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Disease; Disease Models, Animal; Dogs; Female; Ligation; Male; Propranolol; Quinidine; Sotalol; Tachycardia, Ventricular; Verapamil | 1995 |
Change of atrial refractory period after short duration of rapid atrial pacing: regional differences and possible mechanisms.
Topics: Adenosine Triphosphatases; Animals; Anti-Arrhythmia Agents; Atrial Function; Calcium Channels; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Heart Rate; Nicorandil; Potassium Channels; Premedication; Ryanodine; Sotalol; Verapamil | 1999 |
[Transitory left ventricular outflow tract obstruction after mitral valve reconstruction].
Topics: Adrenergic beta-Antagonists; Adult; Echocardiography; Follow-Up Studies; Heart Valve Prosthesis Implantation; Humans; Male; Mitral Valve; Mitral Valve Insufficiency; Mitral Valve Prolapse; Pericardial Effusion; Sotalol; Time Factors; Vasodilator Agents; Ventricular Outflow Obstruction; Verapamil | 1999 |
Effects of the T-type Ca(2+) channel blocker mibefradil on repolarization of guinea pig, rabbit, dog, monkey, and human cardiac tissue.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Diltiazem; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Female; Guinea Pigs; Heart; Heart Atria; Humans; In Vitro Techniques; Male; Mibefradil; Rabbits; Saimiri; Sotalol; Telemetry; Time Factors; Verapamil | 2000 |
Alteration of ventricular fibrillation by flecainide, verapamil, and sotalol: an experimental study.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Electrophysiology; Flecainide; Heart Conduction System; Rabbits; Refractory Period, Electrophysiological; Sotalol; Ventricular Fibrillation; Verapamil | 2000 |
[Atrial fibrillation successfully converted. A new standard in the prevention of recurrence?].
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Calcium Channel Blockers; Chronic Disease; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Humans; Placebos; Quinidine; Randomized Controlled Trials as Topic; Recurrence; Sotalol; Time Factors; Verapamil | 2001 |
Impact of left atrial size reduction on chronic atrial fibrillation in mitral valve surgery.
Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Pacing, Artificial; Cardiopulmonary Bypass; Chronic Disease; Cohort Studies; Digitoxin; Echocardiography; Electric Countershock; Female; Follow-Up Studies; Heart Atria; Heart Conduction System; Heart Valve Diseases; Humans; Male; Middle Aged; Mitral Valve; Postoperative Complications; Sotalol; Survival Analysis; Treatment Outcome; Verapamil | 2003 |
[Correction of rate and structure of ventricular rhythm in permanent atrial fibrillation: a novel pathogenetic approach].
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Digoxin; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Periodicity; Sotalol; Ventricular Premature Complexes; Verapamil | 2004 |
Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs.
Topics: Animals; Calcium Channel Blockers; Dogs; Electrocardiography; Ether-A-Go-Go Potassium Channels; Humans; Male; Phenethylamines; Potassium Channels; Sotalol; Sulfonamides; Torsades de Pointes; Verapamil | 2005 |
[PAFAC Study. Secondary prevention of atrial fibrillation after cardioversion].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Therapy, Combination; Electric Countershock; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Secondary Prevention; Sotalol; Survival Analysis; Treatment Outcome; Verapamil | 2005 |
Severe poisoning with sotalol and verapamil. Recovery after 4 h of normothermic CPR followed by extra corporeal heart lung assist.
Topics: Adrenergic beta-Antagonists; Adult; Calcium Channel Blockers; Cardiopulmonary Resuscitation; Female; Heart Arrest; Heart-Assist Devices; Humans; Respiration, Artificial; Sotalol; Suicide, Attempted; Verapamil | 2005 |
Inadvertent toxic drug reaction in the management of atrial fibrillation.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Digoxin; Drug Interactions; Electrocardiography; Female; Humans; Hypotension; Middle Aged; Sotalol; Time Factors; Verapamil | 2006 |
Attenuation of the negative inotropic effects of metoprolol at short cycle lengths in humans: comparison with sotalol and verapamil.
Topics: Aged; Anti-Arrhythmia Agents; Cardiac Catheterization; Cardiac Pacing, Artificial; Female; Hemodynamics; Humans; Male; Metoprolol; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Pressure; Sotalol; Systole; Time Factors; Ventricular Function, Left; Verapamil | 2006 |
Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry.
Topics: Amiodarone; Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carbazoles; Carvedilol; Chromatography, Liquid; Diltiazem; Humans; Metoprolol; Mexiletine; Molecular Structure; Propanolamines; Propranolol; Reproducibility of Results; Sotalol; Tandem Mass Spectrometry; Verapamil | 2007 |
Evidence that pharmacological strategies lack efficacy for the prevention of sudden death in hypertrophic cardiomyopathy.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathy, Hypertrophic; Child; Child, Preschool; Death, Sudden, Cardiac; Female; Humans; Infant; Kaplan-Meier Estimate; Male; Middle Aged; Retrospective Studies; Sotalol; Verapamil | 2007 |
Halothane-anaesthetized, closed-chest, guinea-pig model for assessment of drug-induced QT-interval prolongation.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Electrocardiography; Guinea Pigs; Halothane; Heart; Heart Rate; Long QT Syndrome; Male; Models, Animal; Sotalol; Verapamil | 2009 |
[Effect of hypotensive therapy on metalloproteinase activity of the blood in patients with arterial hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Enzyme-Linked Immunosorbent Assay; Female; Fibrosis; Follow-Up Studies; Heart Diseases; Humans; Hypertension; Male; Matrix Metalloproteinase 1; Middle Aged; Myocardium; Sotalol; Tissue Inhibitor of Metalloproteinase-1; Treatment Outcome; Vasodilator Agents; Verapamil | 2009 |
Human and murine embryonic stem cell-derived cardiomyocytes serve together as a valuable model for drug safety screening.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Embryonic Stem Cells; Humans; Mice; Myocytes, Cardiac; Quinidine; Sotalol; Verapamil | 2010 |
Pharmacophore modeling for hERG channel facilitation.
Topics: Animals; Atenolol; Chlorpheniramine; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluoxetine; Haloperidol; Humans; Hydrophobic and Hydrophilic Interactions; Imipramine; Metoprolol; Nortriptyline; Potassium Channel Blockers; Promethazine; Propranolol; Quantitative Structure-Activity Relationship; Sotalol; Terfenadine; Verapamil; Xenopus laevis | 2012 |
Verapamil reduces incidence of reentry during ventricular fibrillation in pigs.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Heart Rate; Heart Ventricles; Sotalol; Swine; Ventricular Fibrillation; Ventricular Function; Verapamil | 2014 |
Effects of combination of sotalol and verapamil on initiation, maintenance, and termination of ventricular fibrillation in swine hearts.
Topics: Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Cardiac Pacing, Artificial; Drug Synergism; Heart; Heart Conduction System; Infusions, Intravenous; Refractory Period, Electrophysiological; Sotalol; Sus scrofa; Swine; Ventricular Fibrillation; Verapamil | 2018 |
Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Drug Evaluation, Preclinical; ERG1 Potassium Channel; Female; Heart Ventricles; Humans; Ion Channels; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Rabbits; Sotalol; Sulfonamides; Terfenadine; Tissue Donors; Verapamil | 2019 |
Telemetered common marmosets is useful for the assessment of electrocardiogram parameters changes induced by multiple cardiac ion channel inhibitors.
Topics: Animals; Astemizole; Body Temperature; Calcium Channel Blockers; Callithrix; Electrocardiography; Flecainide; Male; Models, Animal; Quinidine; Risk Assessment; Sotalol; Telemetry; Terfenadine; Verapamil; Voltage-Gated Sodium Channel Blockers | 2019 |
High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS.
Topics: Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carvedilol; Chromatography, High Pressure Liquid; Diltiazem; Flecainide; High-Throughput Screening Assays; Humans; Lidocaine; Metoprolol; Propranolol; Reproducibility of Results; Sotalol; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Verapamil | 2019 |
Assessment of Drug Proarrhythmic Potential in Electrically Paced Human Induced Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Using Multielectrode Array.
Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cations, Divalent; Cell Differentiation; Humans; Induced Pluripotent Stem Cells; Ion Transport; Microelectrodes; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Nifedipine; Patch-Clamp Techniques; Phenethylamines; Primary Cell Culture; Quinidine; Sotalol; Sulfonamides; Tetrodotoxin; Verapamil | 2021 |
The Efficacy of Anti-Arrhythmic Drugs in Children With Idiopathic Frequent Symptomatic or Asymptomatic Premature Ventricular Complexes With or Without Asymptomatic Ventricular Tachycardia: a Retrospective Multi-Center Study.
Topics: Adolescent; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Child; Child, Preschool; Female; Flecainide; Humans; Male; Retrospective Studies; Sotalol; Tachycardia, Ventricular; Treatment Outcome; Ventricular Premature Complexes; Verapamil | 2021 |
Torsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Silico Mechanistic Model.
Topics: Animals; Atrioventricular Block; Bepridil; Cisapride; Computer Simulation; Macaca fascicularis; Sotalol; Torsades de Pointes; Verapamil | 2021 |
Pharmacological characterisation of electrocardiogram J-T
Topics: Animals; DNA-Binding Proteins; Electrocardiography; Flecainide; Guinea Pigs; Long QT Syndrome; Nifedipine; Quinidine; Quinine; Ranolazine; Sotalol; Torsades de Pointes; Verapamil | 2022 |