Page last updated: 2024-08-16

sotalol and uk 68798

sotalol has been researched along with uk 68798 in 91 studies

Research

Studies (91)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	29 (31.87)	18.2507
2000's	39 (42.86)	29.6817
2010's	20 (21.98)	24.3611
2020's	3 (3.30)	2.80

Authors

Authors	Studies
Bagli, JF; Ellingboe, JW; Kitzen, JM; Moubarak, IF; Nguyen, TT; Parsons, RW; Spinelli, W; Von Engen, D; Winkley, MW	1
Anantharaman, V; Bagli, JF; Butera, JA; Cullinan, C; Marcopulos, N; Moubarak, IF; Parsons, RW; Spinelli, W	1
Connors, SP; Dennis, PD; Gill, EW; Terrar, DA	1
Arrowsmith, JE; Burges, RA; Cross, PE; Gwilt, M; Higgins, AJ; Thomas, GN	1
Baizman, ER; Becker, C; Bell, RH; Birsner, NC; Bohnet, EA; Busacca, CA; Carabateas, PM; Chadwick, CC; Gruett, MD; Johnson, RE	1
Kanojia, RM; Kauffman, J; Salata, JJ	1
Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Refsum, H; Tande, PM; Yang, T	1
Colatsky, TJ; Parsons, RW; Spinelli, W	1
Honerjäger, P; Schmidt, G	1
Blackburn, KJ; Burges, RA; Gwilt, M; Higgins, AJ; Milne, AA; Solca, AM	1
Bjørnstad, H; Refsum, H; Tande, PM; Yang, T	1
Baskin, EP; Brookes, LM; Claremon, DA; Lynch, JJ; Selnick, HG; Serik, CM; Wallace, AA	1
Brookes, LM; Claremon, DA; Lynch, JJ; Selnick, HG; Stupienski, RF; Wallace, AA	1
Brunden, MN; Buchanan, LV; Gibson, JK; Kabell, G	1
Krafte, DS; Volberg, WA	1
Baskin, EP; Lynch, JJ	1
De Clerck, F; Lu, HR; Remeysen, P	1
Baskin, EP; Guinosso, PJ; Hamill, T; Lynch, JJ; Nutt, EM; Salata, JJ; Woods, CM	1
Abrahamsson, C; Bäärnhielm, C; Carlsson, L; Danielsson, B; Duker, G; Ljung, B; Palmer, M	1
Colatsky, TJ; Moubarak, IF; Parsons, RW; Spinelli, W	1
Lee, EW; Lee, KS; Tsai, TD	1
Mitamura, H; Ogawa, S; Okada, Y; Sadanaga, T	1
Brown-Woodman, PD; Danielsson, BR; Snow, MD; Webster, WS	1
Montero, M; Schmitt, C	1
Bursill, JA; Campbell, TJ; Wyse, KR	1
Bharucha, D; Kowey, PR; Marinchak, RA; Rials, SJ	1
Beyer, ME; Hoffmeister, HM; Seipel, L	1
MacNeil, DJ	1
Beyer, T; Brachmann, J; Karolyi, L; Kübler, W; Marschang, H	1
Al-Khalidi, H; Brooks, RR; Drexler, AP; Kostreva, DR; Maynard, AE	1
Sager, PT	1
Brachmann, J; Karolyi, L; Kübler, W; Marschang, H; Schöls, W	1
Reiffel, JA	2
Bacchi, L; Biffi, M; Bitonti, F; Boriani, G; Branzi, A; Butrous, G; De Simone, N; Martignani, C; Zannoli, R	1
Bányász, T; Gyönös, I; Kovács, A; Magyar, J; Nánási, PP; Spedding, M; Szénási, G	1
Derakhchan, K; Nattel, S; Talajic, M; Villemaire, C	1
Dorian, P; Qi, X	1
Cox, CD; Tsikouris, JP	1
Biffi, M; Borggrefe, M; Boriani, G; Brachmann, J; Butrous, GS; Capucci, A; Kornacewicz-Jack, Z; Lubinski, A; Niederle, R; Wnuk-Wojnar, AM	1
Bianconi, L; Castro, A; Santini, M	1
Khan, IA	2
Bacchi, L; Biffi, M; Boriani, G; Branzi, A; Butrous, GS; Martignani, C; Zannoli, R	1
Brendel, J; Busch, AE; Knobloch, K; Peukert, S; Rosenstein, B; Wirth, KJ	1
Bhatta, L; Hynes, J; Khan, M; Luck, J; Naccarelli, GV; Samii, S; Wolbrette, DL	1
Wolbrette, DL	1
DeBisschop, M; Lower, DL; Martin, LG; Yamreudeewong, W	1
Pratt, CM	1
Kramer, JM; LaPointe, NM; Pamer, CA	1
Allen LaPointe, NM; Califf, RM; Chen, A; DeLong, E; Hammill, B; Kramer, JM	1
Khan, MH	1
Mounsey, JP; VerNooy, RA	1
Freeland, S; Worthy, C; Zolnierz, M	1
Bleich, M; Brendel, J; Busch, AE; Knobloch, K; Rosenstein, B; Wirth, KJ	1
Borchard, R; Brandts, B; Dirkmann, D; Meine, M; Prull, MW; Trappe, HJ; Van Bracht, M; Wickenbrock, I	1
Brendorp, B; Elming, H; Køber, L; Pedersen, OD; Pehrson, S; Torp-Petersen, C	1
Andreas, JO; Hauser, R; Jahnel, U; Linz, K; Schneider, J	1
Coleman, CI; Guertin, D; Henyan, NN; Kluger, J; McBride, BF; Min, B; Silver, BB; White, CM	1
Chen, XL; Ji, J; Kang, J; Rampe, DE; Reynolds, WP; Wang, H	1
Akhtar, M; Narayan, G; Sra, J	1
Cvetanovic, I; Ke, X; Lin, C; Ranade, V; Somberg, J	1
Bauman, JL; Kehoe, RF; Leal, S; Mykytsey, A; Razminia, M; Saleem, M; Wang, T; Zheutlin, T	1
Clozel, M; Hess, P; Rey, M; Steiner, B; Wanner, D	1
Battleman, DS; Kim, MH; Klingman, D; Lin, J; Pathak, P	1
Ducroq, J; Legrand, JC; Puddu, PE; Rouet, R; Sallé, L	1
Cox, BF; Diaz, GJ; Gintant, GA; Houseman, K; Limberis, JT; Liu, X; Martin, RL; Su, Z	1
Braam, SR; Casini, S; Denning, C; Gallacher, DJ; Lu, HR; Matsa, E; Mummery, CL; Passier, R; Teisman, A; Tertoolen, L; Towart, R	1
Augostini, R; Dakhil, B; Daoud, EG; Hamam, I; Houmsse, M; Hummel, JD; Kalbfleisch, SJ; Liu, Z; Love, C; Rhodes, T; Tsai, SF; Tyler, J; Weiss, R; Winner, M	1
Anderson, JL; Bunch, TJ	1
Clancy, CE; Romero, L; Saiz, J; Trenor, B; Yang, PC	1
Dorsey, P; Hayes, M; Kaplan, R; Passman, R; Sauer, AJ; Shah, SJ; Xue, J	1
Agusala, K; Caprio, T; Kulkarni, C; Oesterle, A; Passman, R; Subacius, H	1
Cools, F; Danhof, M; Gallacher, DJ; Gotta, V; Morissette, P; Sannajust, F; van Ammel, K; van der Graaf, PH; Visser, SA	1
Adelstein, E; Alam, MB; Jain, SK; Khattak, F; Leef, G; Munir, MB; Patel, D; Qin, D; Rattan, R; Saba, S	1
Ackerman, MJ; Asirvatham, SJ; Brady, P; DeSimone, CV; Friedman, P; Kremen, V; Noseworthy, PA; Qiang, B; Sapir, Y; Sheldon, SH; Striemer, BL; Sugrue, A	1
Albert, D; Albert, M; Chohan, J; Garabelli, P; Koomson, E; Parwani, P; Po, S; Reynolds, D; Smith, L; Stavrakis, S; Xie, Q; Xie, R	1
Árpádffy-Lovas, T; Gazdag, P; Geramipour, A; Jost, N; Kohajda, Z; Orvos, P; Szlovák, J; Tálosi, L; Tóth, D; Varró, A; Virág, L	1
Knowles, D; Malloy, R; Ting, C	1
Giles, WR; Jæger, KH; Maleckar, MM; Tveito, A; Wall, S	1
Bai, S; Cao, H; Chen, K; Dong, H; Ma, Y; Pei, J; Tian, L; Zhao, Y	1

Reviews

20 review(s) available for sotalol and uk 68798

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[New anti-arrhythmia agents]. Zeitschrift fur Kardiologie, 1992, Volume: 81 Suppl 4 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Humans; Phenethylamines; Procainamide; Propanolamines; Sotalol; Sulfonamides; Survival Rate; Tachycardia	1992
Pharmacologic and pharmacokinetic profile of class III antiarrhythmic drugs. The American journal of cardiology, 1997, Oct-23, Volume: 80, Issue:8A Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Humans; Phenethylamines; Sotalol; Sulfonamides	1997
The side effect profile of class III antiarrhythmic drugs: focus on d,l-sotalol. The American journal of cardiology, 1997, Oct-23, Volume: 80, Issue:8A Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Female; Heart Conduction System; Heart Failure; Humans; Hypertension; Infant, Newborn; Phenethylamines; Pregnancy; Pregnancy Complications, Cardiovascular; Prenatal Exposure Delayed Effects; Risk Factors; Sotalol; Sulfonamides; Survival Rate; Torsades de Pointes	1997
New advances in class III antiarrhythmic drug therapy. Current opinion in cardiology, 2000, Volume: 15, Issue:1 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiology; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sotalol; Sulfonamides	2000
Drug choices in the treatment of atrial fibrillation. The American journal of cardiology, 2000, May-25, Volume: 85, Issue:10A Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Surgical Procedures; Electric Countershock; Humans; Phenethylamines; Sotalol; Sulfonamides	2000
Antiarrhythmic drugs and ventricular defibrillation energy requirements. Chinese medical journal, 1999, Volume: 112, Issue:12 Topics: Animals; Anti-Arrhythmia Agents; Defibrillators, Implantable; Humans; Phenethylamines; Sotalol; Sulfonamides; Ventricular Fibrillation	1999
A review of class III antiarrhythmic agents for atrial fibrillation: maintenance of normal sinus rhythm. Pharmacotherapy, 2001, Volume: 21, Issue:12 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Clinical Trials as Topic; Drug Interactions; Humans; Phenethylamines; Sotalol; Sulfonamides	2001
New antiarrhythmic drugs for the treatment of atrial fibrillation. Pacing and clinical electrophysiology : PACE, 2002, Volume: 25, Issue:2 Topics: Aminobenzoates; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Dronedarone; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sotalol; Sulfonamides	2002
Transient atrial mechanical dysfunction (stunning) after cardioversion of atrial fibrillation and flutter. American heart journal, 2002, Volume: 144, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Appendage; Atrial Fibrillation; Atrial Flutter; Catheter Ablation; Dogs; Electric Countershock; Heart Atria; Humans; Myocardial Contraction; Myocardial Stunning; Phenethylamines; Regional Blood Flow; Sotalol; Sulfonamides; Ultrasonography; Verapamil	2002
Old and new antiarrhythmic drugs for converting and maintaining sinus rhythm in atrial fibrillation: comparative efficacy and results of trials. The American journal of cardiology, 2003, Mar-20, Volume: 91, Issue:6A Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Australia; Canada; Controlled Clinical Trials as Topic; Europe; Flecainide; Heart Conduction System; Heart Failure; Humans; Multicenter Studies as Topic; Myocardial Infarction; Phenethylamines; Propafenone; Quinidine; Sotalol; Sulfonamides; Survival Analysis; Therapeutic Equivalency; Treatment Outcome; United States	2003
Risk of proarrhythmia with class III antiarrhythmic agents: sex-based differences and other issues. The American journal of cardiology, 2003, Mar-20, Volume: 91, Issue:6A Topics: Amiodarone; Anti-Arrhythmia Agents; Electrocardiography; Female; Heart Conduction System; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Phenethylamines; Piperazines; Risk Assessment; Risk Factors; Sex Factors; Sotalol; Sulfonamides; Tachycardia; Torsades de Pointes	2003
Potentially significant drug interactions of class III antiarrhythmic drugs. Drug safety, 2003, Volume: 26, Issue:6 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Drug Interactions; Humans; Phenethylamines; Sotalol; Sulfonamides	2003
Pure class III agents for prevention of sudden cardiac death. Journal of cardiovascular electrophysiology, 2003, Volume: 14, Issue:9 Suppl Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Comorbidity; Death, Sudden, Cardiac; Europe; Humans; Hydantoins; Imidazoles; Imidazolidines; Middle Aged; Myocardial Infarction; Phenethylamines; Piperazines; Randomized Controlled Trials as Topic; Sotalol; Sulfonamides; Survival Analysis; Treatment Outcome	2003
Atrial stunning: basics and clinical considerations. International journal of cardiology, 2003, Volume: 92, Issue:2-3 Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Atrial Function; Atrial Function, Left; Atrial Function, Right; Catheter Ablation; Electric Countershock; Humans; Isoproterenol; Myocardial Stunning; Phenethylamines; Sotalol; Sulfonamides; Thromboembolism; Time Factors; Verapamil	2003
Oral class III antiarrhythmics: what is new? Current opinion in cardiology, 2004, Volume: 19, Issue:1 Topics: Amiodarone; Anti-Arrhythmia Agents; Dronedarone; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sotalol; Sulfonamides; Tachycardia, Supraventricular; Tachycardia, Ventricular; Treatment Outcome	2004
Antiarrhythmic drug therapy of atrial fibrillation. Cardiology clinics, 2004, Volume: 22, Issue:1 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Flecainide; Humans; Phenethylamines; Sotalol; Sulfonamides	2004
A benefit-risk assessment of class III antiarrhythmic agents. Expert opinion on drug safety, 2004, Volume: 3, Issue:6 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Combined Modality Therapy; Defibrillators, Implantable; Dronedarone; Heart Conduction System; Humans; Hydantoins; Imidazolidines; Ion Transport; Life Tables; Membrane Potentials; Meta-Analysis as Topic; Phenethylamines; Piperazines; Risk Assessment; Sotalol; Sulfonamides; Survival Analysis; Torsades de Pointes; Treatment Outcome	2004
Adjuvant antiarrhythmic therapy in patients with implantable cardioverter defibrillators. American journal of cardiovascular drugs : drugs, devices, and other interventions, 2014, Volume: 14, Issue:2 Topics: Amiodarone; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Benzofurans; Defibrillators, Implantable; Humans; Hydantoins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazolidines; Mineralocorticoid Receptor Antagonists; Phenethylamines; Piperazines; Sotalol; Sulfonamides	2014
Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis. British journal of pharmacology, 2015, Volume: 172, Issue:17 Topics: Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fluoroquinolones; Heart Conduction System; Heart Rate; Humans; Long QT Syndrome; Male; Moxifloxacin; Phenethylamines; Potassium Channel Blockers; Reproducibility of Results; Sotalol; Sulfonamides; Telemetry; Translational Research, Biomedical	2015

Trials

6 trial(s) available for sotalol and uk 68798

Article	Year
Assessment of reverse use-dependent blocking actions of class III antiarrhythmic drugs by 24-hour Holter electrocardiography. Journal of the American College of Cardiology, 1996, Volume: 27, Issue:1 Topics: Adult; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Electrocardiography, Ambulatory; Female; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Piperidines; Pyridines; Pyrimidinones; Regression Analysis; Sotalol; Statistics, Nonparametric; Sulfonamides	1996
Repolarization changes in a double-blind crossover study of dofetilide versus sotalol in the treatment of ventricular tachycardia. Pacing and clinical electrophysiology : PACE, 2000, Volume: 23, Issue:11 Pt 2 Topics: Anti-Arrhythmia Agents; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Phenethylamines; Sotalol; Sulfonamides; Tachycardia, Ventricular; Treatment Outcome	2000
A multicentre, double-blind randomized crossover comparative study on the efficacy and safety of dofetilide vs sotalol in patients with inducible sustained ventricular tachycardia and ischaemic heart disease. European heart journal, 2001, Volume: 22, Issue:23 Topics: Adult; Aged; Anti-Arrhythmia Agents; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Phenethylamines; Sotalol; Statistics as Topic; Sulfonamides; Tachycardia, Ventricular	2001
A randomised cross-over study on the haemodynamic effects of oral dofetilide compared with oral sotalol in patients with ischaemic heart disease and sustained ventricular tachycardia. European journal of clinical pharmacology, 2002, Volume: 58, Issue:3 Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Cross-Over Studies; Hemodynamics; Humans; Middle Aged; Myocardial Ischemia; Phenethylamines; Sotalol; Sulfonamides; Ventricular Fibrillation	2002
An evaluation of the impact of oral magnesium lactate on the corrected QT interval of patients receiving sotalol or dofetilide to prevent atrial or ventricular tachyarrhythmia recurrence. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2006, Volume: 11, Issue:2 Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chi-Square Distribution; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Female; Humans; Lactic Acid; Magnesium Compounds; Male; Phenethylamines; Recurrence; Sotalol; Statistics, Nonparametric; Sulfonamides; Treatment Outcome	2006
Observations on the safety and effectiveness of dofetilide in patients with paroxysmal atrial fibrillation and normal left ventricular function. Journal of cardiovascular pharmacology and therapeutics, 2007, Volume: 12, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Dose-Response Relationship, Drug; Drug Monitoring; Female; Flecainide; Follow-Up Studies; Humans; Inpatients; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Propafenone; Recurrence; Sotalol; Sulfonamides; Tachycardia, Ventricular; Treatment Outcome; Ventricular Function, Left; Withholding Treatment	2007

Other Studies

65 other study(ies) available for sotalol and uk 68798

Article	Year
Class III antiarrhythmic activity of novel substituted 4-[(methylsulfonyl)amino]benzamides and sulfonamides. Journal of medicinal chemistry, 1992, Feb-21, Volume: 35, Issue:4 Topics: Action Potentials; Anti-Arrhythmia Agents; Atrial Function; Benzamides; Benzimidazoles; Biological Availability; Electric Conductivity; Heart Atria; Heart Conduction System; Heart Ventricles; Membrane Potentials; Molecular Structure; Myocardial Contraction; Purkinje Fibers; Structure-Activity Relationship; Sulfanilamides; Sulfonamides; Ventricular Fibrillation; Ventricular Function	1992
Synthesis and selective class III antiarrhythmic activity of novel N-heteroaralkyl-substituted 1-(aryloxy)-2-propanolamine and related propylamine derivatives. Journal of medicinal chemistry, 1991, Volume: 34, Issue:11 Topics: Animals; Anti-Arrhythmia Agents; Cats; Dogs; Electrophysiology; Guinea Pigs; Membrane Potentials; Propanolamines; Propylamines; Purkinje Fibers; Quinolines; Structure-Activity Relationship	1991
The synthesis and potassium channel blocking activity of some (4-methanesulfonamidophenoxy)propanolamines as potential class III antiarrhythmic agents. Journal of medicinal chemistry, 1991, Volume: 34, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Chemical Phenomena; Chemistry; Guinea Pigs; Heart Rate; Potassium Channels; Propanolamines; Rats; Structure-Activity Relationship	1991
Selective class III antiarrhythmic agents. 1 Bis(arylalkyl)amines. Journal of medicinal chemistry, 1990, Volume: 33, Issue:4 Topics: Action Potentials; Amines; Animals; Anti-Arrhythmia Agents; Chemical Phenomena; Chemistry; Dogs; Electric Stimulation; Guinea Pigs; Heart; Hemodynamics; Phenethylamines; Potassium Channels; Refractory Period, Electrophysiological; Structure-Activity Relationship; Sulfonamides	1990
4,5-Dihydro-1-phenyl-1H-2,4-benzodiazepines: novel antiarrhythmic agents. Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzodiazepines; Cats; Disease Models, Animal; Dogs; Guinea Pigs; Heart Ventricles; Male; Myocardial Contraction; Myocardial Infarction; Potassium Channels; Rats; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; Sodium Channels; Structure-Activity Relationship	1993
Synthesis and class III type antiarrhythmic activity of 4-aroyl (and aryl)-l-aralkylpiperazines. Bioorganic & medicinal chemistry letters, 2000, Dec-18, Volume: 10, Issue:24 Topics: Animals; Anti-Arrhythmia Agents; Biological Assay; Ferrets; In Vitro Techniques; Isometric Contraction; Male; Papillary Muscles; Piperazines; Piperidines; Structure-Activity Relationship	2000
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation. European journal of medicinal chemistry, 2008, Volume: 43, Issue:11 Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Electromechanical action of dofetilide and D-sotalol during simulated metabolic acidosis in isolated guinea pig ventricular muscle. Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:6 Topics: Acidosis; Action Potentials; Animals; Anti-Arrhythmia Agents; Female; Guinea Pigs; Heart; Heart Ventricles; Hydrogen-Ion Concentration; In Vitro Techniques; Membrane Potentials; Myocardial Contraction; Papillary Muscles; Phenethylamines; Sotalol; Sulfonamides	1992
Effects of WAY-123,398, a new class III antiarrhythmic agent, on cardiac refractoriness and ventricular fibrillation threshold in anesthetized dogs: a comparison with UK-68798, E-4031, and dl-sotalol. Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:6 Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Benzimidazoles; Dogs; Electrocardiography; Electrophysiology; Female; Heart; Heart Conduction System; Hemodynamics; In Vitro Techniques; Male; Phenethylamines; Piperidines; Purkinje Fibers; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfanilamides; Sulfonamides; Ventricular Fibrillation	1992
Electropharmacology of dofetilide, a new class III agent, in anaesthetised dogs. European journal of pharmacology, 1992, May-14, Volume: 215, Issue:2-3 Topics: Action Potentials; Anesthesia; Animals; Anti-Arrhythmia Agents; Dogs; Heart; Heart Ventricles; Hemodynamics; Phenethylamines; Potassium Channels; Procainamide; Refractory Period, Electrophysiological; Sotalol; Sulfonamides; Ventricular Fibrillation	1992
Rate-dependent class III antiarrhythmic action, negative chronotropy, and positive inotropy of a novel Ik blocking drug, UK-68,798: potent in guinea pig but no effect in rat myocardium. Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:3 Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Atria; Heart Rate; Myocardial Contraction; Papillary Muscles; Phenethylamines; Rats; Rats, Inbred Strains; Sodium Channels; Sotalol; Species Specificity; Stimulation, Chemical; Sulfonamides	1990
Effects of new and potent methanesulfonanilide class III antiarrhythmic agents on myocardial refractoriness and contractility in isolated cardiac muscle. Journal of cardiovascular pharmacology, 1991, Volume: 18, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Ferrets; Heart; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Phenethylamines; Piperidines; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides; Temperature	1991
Cardiac electrophysiologic and inotropic actions of new and potent methanesulfonanilide class III antiarrhythmic agents in anesthetized dogs. Journal of cardiovascular pharmacology, 1991, Volume: 18, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiology; Female; Heart; Hemodynamics; Male; Myocardial Contraction; Phenethylamines; Piperidines; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides	1991
Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Heart Conduction System; Heart Rate; Male; Methoxamine; Phenethylamines; Piperidines; Pyridines; Quaternary Ammonium Compounds; Rabbits; Software; Sotalol; Sulfonamides; Torsades de Pointes	1993
Voltage dependence of cardiac delayed rectifier block by methanesulfonamide class III antiarrhythmic agents. Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Phenethylamines; Piperidines; Procainamide; Pyridines; Sotalol; Stereoisomerism; Sulfonamides; Ventricular Function	1994
Comparative effects of increased extracellular potassium and pacing frequency on the class III activities of methanesulfonanilide IKr blockers dofetilide, D-sotalol, E-4031, and MK-499. Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Electric Stimulation; Ferrets; Male; Phenethylamines; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides	1994
Antifibrillary action of class I-IV antiarrhythmic agents in the model of ventricular fibrillation threshold of anesthetized guinea pigs. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:1 Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Atenolol; Benzopyrans; Chromans; Disease Models, Animal; Electric Stimulation; Electrocardiography; Encainide; Ethanolamines; Guinea Pigs; Heart; Heart Conduction System; Injections, Intravenous; Male; Metoprolol; Nebivolol; Phenethylamines; Piperidines; Sotalol; Sulfonamides; Ventricular Fibrillation; Verapamil	1995
Comparison of binding to rapidly activating delayed rectifier K+ channel, IKr, and effects on myocardial refractoriness for class III antiarrhythmic agents. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Binding, Competitive; Chromans; Electrophysiology; Guinea Pigs; Heart Ventricles; Papillary Muscles; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Procainamide; Pyridines; Sotalol; Structure-Activity Relationship; Sulfonamides; Tritium	1995
Induction of rhythm abnormalities in the fetal rat heart. A tentative mechanism for the embryotoxic effect of the class III antiarrhythmic agent almokalant. Cardiovascular research, 1994, Volume: 28, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Culture Techniques; Female; Fetal Death; Fetal Heart; Heart; Heart Rate; Myocardium; Phenethylamines; Pregnancy; Propanolamines; Rats; Rats, Sprague-Dawley; Sotalol; Sulfonamides	1994
Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes. Cardiovascular research, 1993, Volume: 27, Issue:9 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzimidazoles; Cats; Cells, Cultured; Culture Techniques; Dogs; Dose-Response Relationship, Drug; Myocardium; Phenethylamines; Piperidines; Potassium Channels; Purkinje Fibers; Pyridines; Sotalol; Sulfanilamides; Sulfonamides	1993
Membrane activity of class III antiarrhythmic compounds; a comparison between ibutilide, d-sotalol, E-4031, sematilide and dofetilide. European journal of pharmacology, 1993, Mar-30, Volume: 234, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Phenethylamines; Piperidines; Potassium Channels; Procainamide; Pyridines; Sotalol; Sulfonamides	1993
Teratogenic potential of almokalant, dofetilide, and d-sotalol: drugs with potassium channel blocking activity. Teratology, 1996, Volume: 53, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Cleft Palate; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Female; Heart Rate, Fetal; Limb Deformities, Congenital; Male; Organ Culture Techniques; Phenethylamines; Potassium Channel Blockers; Pregnancy; Pregnancy Outcome; Propanolamines; Rats; Rats, Sprague-Dawley; Sotalol; Sulfonamides	1996
Recording of transmembrane action potentials in chronic ischemic heart disease and dilated cardiomyopathy and the effects of the new class III antiarrhythmic agents D-sotalol and dofetilide. Journal of cardiovascular pharmacology, 1996, Volume: 27, Issue:4 Topics: Anti-Arrhythmia Agents; Cardiomyopathies; Coronary Disease; Heart; Heart Ventricles; Humans; In Vitro Techniques; Membrane Potentials; Phenethylamines; Sotalol; Sulfonamides	1996
Differential effects of antiarrhythmic agents on post-pause repolarization in cardiac Purkinje fibres. Clinical and experimental pharmacology & physiology, 1996, Volume: 23, Issue:9 Topics: Action Potentials; Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Anti-Arrhythmia Agents; Disopyramide; Dogs; Dose-Response Relationship, Drug; Phenethylamines; Potassium Channels; Purkinje Fibers; Quaternary Ammonium Compounds; Quinidine; Sodium Channels; Sotalol; Sulfonamides	1996
Hemodynamic effects of antiarrhythmic compounds: intrinsic effects and autonomic modulation. The American journal of cardiology, 1997, Oct-23, Volume: 80, Issue:8A Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Heart Conduction System; Hemodynamics; Humans; Male; Myocardial Contraction; Phenethylamines; Rats; Rats, Wistar; Sotalol; Sulfonamides	1997
Differential rate and potassium-dependent effects of the class III agents d-sotalol and dofetilide on guinea pig papillary muscle. Cardiovascular drugs and therapy, 1998, Volume: 12, Issue:6 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrophysiology; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Myocardium; Papillary Muscles; Phenethylamines; Potassium; Sotalol; Sulfonamides	1998
Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 223, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Female; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Male; Methoxamine; Phenethylamines; Piperazines; Procainamide; Quaternary Ammonium Compounds; Rabbits; Sotalol; Sulfonamides	2000
Isoproterenol specifically modulates reverse rate-dependent effects of d,l-sotalol, d-sotalol, and dofetilide. Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Dogs; Electric Stimulation; Electrophysiology; Heart; Isomerism; Isoproterenol; Membrane Potentials; Phenethylamines; Sotalol; Sulfonamides	2000
Effects of EGIS-7229 (S 21407), a novel class III antiarrhythmic drug, on myocardial refractoriness to electrical stimulation in vivo and in vitro. Journal of cardiovascular pharmacology, 2001, Volume: 37, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Female; Hemodynamics; Male; Papillary Muscles; Phenethylamines; Pyridazines; Rabbits; Sotalol; Sulfonamides; Ventricular Fibrillation; Ventricular Function, Right	2001
The class III antiarrhythmic drugs dofetilide and sotalol prevent AF induction by atrial premature complexes at doses that fail to terminate AF. Cardiovascular research, 2001, Volume: 50, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Premature Complexes; Dogs; Drug Administration Schedule; Electric Stimulation; Electrophysiology; Heart Conduction System; Phenethylamines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides	2001
Is it rational, reasonable or excessive, and consistently applied? One view of the increasing FDA emphasis on safety first for the release and use of antiarrhythmic drugs for supraventricular arrhythmias. Journal of cardiovascular pharmacology and therapeutics, 2001, Volume: 6, Issue:4 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Approval; Drugs, Generic; Heart Ventricles; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sotalol; Sulfonamides; United States; United States Food and Drug Administration	2001
Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide. Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 366, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Atrial Function; Biphenyl Compounds; Cation Transport Proteins; Electrophysiology; Ether-A-Go-Go Potassium Channels; Heart Atria; Hydantoins; Imidazoles; Imidazolidines; Kv1.5 Potassium Channel; Male; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Sotalol; Sulfonamides; Swine; Ventricular Function	2002
New antiarrhythmic agents for atrial fibrillation and atrial flutter: United States drug market response as an indicator of acceptance. Pharmacotherapy, 2003, Volume: 23, Issue:10 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Databases, Factual; Drug Prescriptions; Drug Utilization; Humans; Phenethylamines; Sotalol; Sulfonamides; United States	2003
Evaluation of the dofetilide risk-management program. American heart journal, 2003, Volume: 146, Issue:5 Topics: Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Electrocardiography; Female; Guideline Adherence; Humans; Incidence; Male; Middle Aged; North Carolina; Phenethylamines; Practice Guidelines as Topic; Product Labeling; Program Evaluation; Risk Management; Sotalol; Sulfonamides; Torsades de Pointes	2003
Initiation and monitoring of class III antiarrhythmic agents. Journal of cardiovascular electrophysiology, 2003, Volume: 14, Issue:12 Suppl Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Administration Schedule; Drug Approval; Drug Labeling; Drug Monitoring; Drug Therapy, Computer-Assisted; Humans; Patient Care Management; Patient Care Team; Phenethylamines; Practice Guidelines as Topic; Sotalol; Sulfonamides; Torsades de Pointes	2003
Atrial-selective antiarrhythmic actions of novel Ikur vs. Ikr, Iks, and IKAch class Ic drugs and beta blockers in pigs. Medical science monitor : international medical journal of experimental and clinical research, 2004, Volume: 10, Issue:7 Topics: Adrenergic beta-Antagonists; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Function; Atropine; Biphenyl Compounds; Chromans; Flecainide; Heart Atria; Hydantoins; Imidazoles; Imidazolidines; Male; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels; Propafenone; Propanolamines; Sotalol; Sulfonamides; Swine; Ventricular Function	2004
[Perspectives and limitations in the treatment of vagus-induced atrial fibrillation. Insights from cellular pharmacology]. Medizinische Klinik (Munich, Germany : 1983), 2004, Jul-15, Volume: 99, Issue:7 Topics: Adult; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Cells, Cultured; Culture Media; Heart Atria; Humans; Membrane Potentials; Phenethylamines; Potassium Channel Blockers; Rats; Sotalol; Sulfonamides; Time Factors; Vagus Nerve	2004
Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs. European journal of pharmacology, 2005, Apr-04, Volume: 512, Issue:1 Topics: Animals; Calcium Channel Blockers; Dogs; Electrocardiography; Ether-A-Go-Go Potassium Channels; Humans; Male; Phenethylamines; Potassium Channels; Sotalol; Sulfonamides; Torsades de Pointes; Verapamil	2005
Mechanisms underlying the QT interval-prolonging effects of sevoflurane and its interactions with other QT-prolonging drugs. Anesthesiology, 2006, Volume: 104, Issue:5 Topics: Action Potentials; Adrenergic beta-Antagonists; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Cell Separation; CHO Cells; Cricetinae; Drug Interactions; Guinea Pigs; Humans; In Vitro Techniques; Ion Channels; Long QT Syndrome; Methyl Ethers; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Sevoflurane; Sotalol; Sulfonamides	2006
Combined use of 1C and III agents for highly symptomatic, refractory atrial fibrillation. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2006, Volume: 15, Issue:3 Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Chronic Disease; Drug Combinations; Female; Flecainide; Humans; Male; Middle Aged; Phenethylamines; Propafenone; Secondary Prevention; Sotalol; Sulfonamides; Treatment Failure; Treatment Outcome	2006
The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents. Cardiology, 2007, Volume: 108, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Disease Models, Animal; Electrophysiology; Extracellular Matrix; Female; Hydantoins; Hyperkalemia; Imidazolidines; Oocytes; Phenethylamines; Piperazines; Potassium Channels; Potassium Channels, Voltage-Gated; Probability; Sensitivity and Specificity; Sotalol; Sulfonamides; Xenopus laevis	2007
Measurements of blood pressure and electrocardiogram in conscious freely moving guineapigs: a model for screening QT interval prolongation effects. Laboratory animals, 2007, Volume: 41, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Electrocardiography; Enalapril; Guinea Pigs; Heart Rate; Histamine H1 Antagonists, Non-Sedating; Male; Models, Animal; Phenethylamines; Sotalol; Sulfonamides; Telemetry; Terfenadine	2007
Cost of hospital admission for antiarrhythmic drug initiation in atrial fibrillation. The Annals of pharmacotherapy, 2009, Volume: 43, Issue:5 Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Female; Health Care Costs; Hospitalization; Humans; Male; Middle Aged; Phenethylamines; Retrospective Studies; Sotalol; Sulfonamides	2009
I(Kr) vs. I(Ks) blockade and arrhythmogenicity in normoxic rabbit Purkinje fibers: does it really make a difference? Fundamental & clinical pharmacology, 2011, Volume: 25, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chromans; Delayed Rectifier Potassium Channels; Epinephrine; Hydantoins; Imidazolidines; In Vitro Techniques; Male; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Purkinje Fibers; Rabbits; Sotalol; Sulfonamides	2011
Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers. Life sciences, 2012, Apr-20, Volume: 90, Issue:15-16 Topics: Acetates; Analysis of Variance; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Patch-Clamp Techniques; Phenethylamines; Pyrazoles; Sotalol; Sulfonamides; Terfenadine; Tritium	2012
Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. Stem cell research, 2013, Volume: 10, Issue:1 Topics: Action Potentials; Cell Differentiation; Cells, Cultured; Humans; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Pluripotent Stem Cells; Potassium; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Sotalol; Sulfonamides	2013
QTc compared to JTc for monitoring drug-induced repolarization changes in the setting of ventricular pacing. Heart rhythm, 2014, Volume: 11, Issue:3 Topics: Aged; Anti-Arrhythmia Agents; Electrocardiography; Female; Heart Conduction System; Humans; Male; Pacemaker, Artificial; Phenethylamines; Sotalol; Sulfonamides	2014
In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. Journal of molecular and cellular cardiology, 2014, Volume: 72 Topics: Action Potentials; Anti-Arrhythmia Agents; Astemizole; Cisapride; Computer Simulation; Gene Expression; Genetic Predisposition to Disease; Heart Ventricles; Humans; Ion Channel Gating; Kinetics; Long QT Syndrome; Models, Statistical; Mutation; Phenethylamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Protein Conformation; Severity of Illness Index; Sotalol; Sulfonamides; Terfenadine	2014
Electrocardiographic markers of repolarization heterogeneity during dofetilide or sotalol initiation for paroxysmal atrial fibrillation. The American journal of cardiology, 2014, Jun-15, Volume: 113, Issue:12 Topics: Age Factors; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Cohort Studies; Diagnosis, Computer-Assisted; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Heart Rate; Humans; Logistic Models; Male; Middle Aged; Phenethylamines; Recovery of Function; Retrospective Studies; Risk Assessment; Sex Factors; Software; Sotalol; Sulfonamides; Tachycardia, Paroxysmal; Treatment Outcome	2014
Risk prediction for adverse events during initiation of sotalol and dofetilide for the treatment of atrial fibrillation. Pacing and clinical electrophysiology : PACE, 2015, Volume: 38, Issue:4 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Comorbidity; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Illinois; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Prevalence; Retrospective Studies; Risk Factors; Sotalol; Sulfonamides; Treatment Outcome; Ventricular Fibrillation	2015
Comparative effectiveness of antiarrhythmic drugs for rhythm control of atrial fibrillation. Journal of cardiology, 2016, Volume: 67, Issue:5 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cohort Studies; Dronedarone; Female; Humans; Male; Patient Admission; Pennsylvania; Phenethylamines; Recurrence; Retrospective Studies; Sotalol; Stroke; Sulfonamides	2016
Electrocardiographic Predictors of Torsadogenic Risk During Dofetilide or Sotalol Initiation: Utility of a Novel T Wave Analysis Program. Cardiovascular drugs and therapy, 2015, Volume: 29, Issue:5 Topics: Aged; Anti-Arrhythmia Agents; Case-Control Studies; Electrocardiography; Female; Humans; Male; Middle Aged; Phenethylamines; Predictive Value of Tests; Software; Sotalol; Sulfonamides; Torsades de Pointes	2015
Comparison of QT Interval Readings in Normal Sinus Rhythm Between a Smartphone Heart Monitor and a 12-Lead ECG for Healthy Volunteers and Inpatients Receiving Sotalol or Dofetilide. Journal of cardiovascular electrophysiology, 2016, Volume: 27, Issue:7 Topics: Action Potentials; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Case-Control Studies; Electrocardiography; Female; Healthy Volunteers; Heart Rate; Humans; Inpatients; Male; Middle Aged; Mobile Applications; Phenethylamines; Predictive Value of Tests; Reproducibility of Results; Smartphone; Sotalol; Sulfonamides	2016
Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential. Toxicological sciences : an official journal of the Society of Toxicology, 2019, 04-01, Volume: 168, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Drug Evaluation, Preclinical; ERG1 Potassium Channel; Female; Heart Ventricles; Humans; Ion Channels; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Rabbits; Sotalol; Sulfonamides; Terfenadine; Tissue Donors; Verapamil	2019
Assessment of Sotalol and Dofetilide Dosing at a Large Academic Medical Center. Journal of cardiovascular pharmacology and therapeutics, 2020, Volume: 25, Issue:5 Topics: Academic Medical Centers; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Boston; Drug Dosage Calculations; Drug Monitoring; Female; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Practice Patterns, Physicians'; Retrospective Studies; Risk Assessment; Risk Factors; Sotalol; Sulfonamides; Torsades de Pointes	2020
Computational translation of drug effects from animal experiments to human ventricular myocytes. Scientific reports, 2020, 06-29, Volume: 10, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Heart Ventricles; Humans; Models, Cardiovascular; Myocytes, Cardiac; Phenethylamines; Rabbits; Sotalol; Sulfonamides; Translational Research, Biomedical	2020
Assessment of Drug Proarrhythmic Potential in Electrically Paced Human Induced Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Using Multielectrode Array. SLAS discovery : advancing life sciences R & D, 2021, Volume: 26, Issue:3 Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cations, Divalent; Cell Differentiation; Humans; Induced Pluripotent Stem Cells; Ion Transport; Microelectrodes; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Nifedipine; Patch-Clamp Techniques; Phenethylamines; Primary Cell Culture; Quinidine; Sotalol; Sulfonamides; Tetrodotoxin; Verapamil	2021