Page last updated: 2024-08-16

sotalol and mexiletine

sotalol has been researched along with mexiletine in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (17.50)	18.7374
1990's	10 (25.00)	18.2507
2000's	13 (32.50)	29.6817
2010's	10 (25.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Calogeropoulou, T; Horváth, Z; Koini, EN; Koncz, I; Koufaki, M; Papazafiri, P; Papp, GJ; Varró, A; Vassilopoulos, A; Virág, L	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Campillo, NE; Guerra, A; Páez, JA	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jung, W; Lüderitz, B; Manz, M	1
Deiwick, M; Konertz, W; Scheld, HH; Weyand, M	1
Lathrop, DA; Varró, A	1
Ahmed, A; Berman, ND; Wang, LY	2
Harron, DW	1
Lüderitz, B; Manz, M; Wagner, WL	1
Berman, ND; Loukides, JE	1
Huang, SK; Marcus, FI	1
Campbell, RW	1
Harron, DW; Kobinger, W; Lillie, C	1
Atallah, G; Kirkorian, G; Moleur, P; Touboul, P	1
Chézalviel-Guilbert, F; Davy, JM; Poirier, JM; Weissenburger, J	1
Cheymol, G; Chézalviel, F; Davy, JM; Guhennec, C; Jagueux, M; Poirier, JM; Simandoux, V; Vernhet, L; Weissenburger, J	1
Biblo, LA; Carlson, MD; Waldo, AL	1
Antzelevitch, C; Shimizu, W	1
Antzelevitch, C; Antzelevitch, D; Heilmann, C; Sicouri, S	1
Alexy, T; Battyany, I; Halmosi, R; Hideg, K; Horvath, B; Kesmarky, G; Marton, Z; Toth, K; Vekasi, J	1
Bogáts, G; Hála, O; Iost, N; Mátyus, P; Opincariu, M; Papp, JG; Szécsi, J; Szenohradszky, P; Szolnoki, J; Varró, A; Virág, L	1
Atkins, CE; DeFrancesco, TC; Gordon, SG; Hamlin, RL; Keene, BW; Meurs, KM; Miller, MW; Moise, NS; Spier, AW; Wright, NA	1
Hennersdorf, MG; Niebch, V; Perings, C; Strauer, BE; Vester, EG; Winter, J	1
Kállay, N; Károlyházy, L; Kocsis, A; Mátyus, P; Papp, JG; Pénzes, I; Rettegi, T; Simay, A; Varga, I; Varró, A	1
Cárdenas, M; Hermosillo, AG; Márquez, MF; Pastelín, G; Salica, G	1
Cai, Y; Jia, J; Li, S; Liu, G; Liu, Y; Pan, C; Ren, J; Yu, C	1
Gelzer, AR; Hemsley, SA; Kraus, MS; Moïse, NS; Rishniw, M	1
Anderson, JL; Bair, TL; Bunch, TJ; Crandall, BG; Day, JD; Lappe, DL; Mader, KM; Mahapatra, S; May, HT; Molden, J; Muhlestein, JB; Murdock, D; Osborn, JS; Weiss, JP	1
Hariman, RJ; Khin, MM; Zoble, RG	1
Kurosawa, TA; Sanders, RA	1
Ermakov, S; Gerstenfeld, EP; Hoffmayer, KS; Scheinman, MM	1
Al-Khatib, SM; Allen LaPointe, NM; Curtis, LH; Hammill, BG; Mi, X; Pokorney, SD	1

Reviews

5 review(s) available for sotalol and mexiletine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Antiarrhythmic drug therapy of ventricular arrhythmias. Current problems in cardiology, 1986, Volume: 11, Issue:4 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil	1986
[New antiarrythmic drugs: mexiletine, tocainide, lorcainide, encainide, flecainide, propafenone, cipralan, sotalol]. Annales de cardiologie et d'angeiologie, 1982, Volume: 31, Issue:7 Topics: Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Electrophysiology; Encainide; Flecainide; Hemodynamics; Humans; Imidazoles; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Sotalol; Tocainide	1982
Novel antiarrhythmic compounds with combined class IB and class III mode of action. Current medicinal chemistry, 2004, Volume: 11, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Coronary Disease; Delayed Rectifier Potassium Channels; Drug Design; Heart Conduction System; Heart Ventricles; Mexiletine; Papillary Muscles; Phenethylamines; Potassium Channels; Potassium Channels, Voltage-Gated; Sotalol; Sulfonamides; Ventricular Function	2004
Drug therapy in Brugada syndrome. Current drug targets. Cardiovascular & haematological disorders, 2005, Volume: 5, Issue:5 Topics: Bundle-Branch Block; Cilostazol; Electrocardiography; Humans; Isoproterenol; Mexiletine; Sotalol; Syndrome; Tetrazoles	2005

Trials

4 trial(s) available for sotalol and mexiletine

Article	Year
[Combination of sotalol with the class I B substances mexiletine or tocainide in complex ventricular extrasystole]. Zeitschrift fur Kardiologie, 1987, Volume: 76, Issue:5 Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Sotalol; Tocainide	1987
Insights into the Electrophysiology Study Versus Electrocardiographic Monitoring Trial: its programmed stimulation protocol may introduce bias when assessing long-term antiarrhythmic drug therapy. Journal of the American College of Cardiology, 1995, Volume: 25, Issue:7 Topics: Anti-Arrhythmia Agents; Bias; Cardiac Pacing, Artificial; Drug Combinations; Electrocardiography, Ambulatory; Electrophysiology; Follow-Up Studies; Humans; Mexiletine; Procainamide; Quinidine; Research Design; Retrospective Studies; Sotalol; Tachycardia, Ventricular	1995
Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers. Journal of the American Veterinary Medical Association, 2002, Aug-15, Volume: 221, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atenolol; Dog Diseases; Dogs; Drug Therapy, Combination; Heart Rate; Mexiletine; Procainamide; Random Allocation; Sotalol; Syncope; Treatment Outcome; Ventricular Premature Complexes	2002
Combination therapy with mexiletine and sotalol suppresses inherited ventricular arrhythmias in German shepherd dogs better than mexiletine or sotalol monotherapy: a randomized cross-over study. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology, 2010, Volume: 12, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cross-Over Studies; Dog Diseases; Dogs; Drug Therapy, Combination; Electrocardiography, Ambulatory; Female; Male; Mexiletine; Prospective Studies; Sotalol; Tachycardia, Ventricular; Ventricular Premature Complexes	2010

Other Studies

31 other study(ies) available for sotalol and mexiletine

Article	Year
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
5,7,8-Trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury. Journal of medicinal chemistry, 2009, Apr-23, Volume: 52, Issue:8 Topics: Action Potentials; Amides; Animals; Anti-Arrhythmia Agents; Antioxidants; Benzopyrans; Benzoxazines; Female; Heart; Lipid Peroxidation; Male; Myocardial Reperfusion Injury; Papillary Muscles; Rabbits; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
[Combination anti-arrhythmic drug therapy]. Zeitschrift fur Kardiologie, 1992, Volume: 81 Suppl 4 Topics: Amiodarone; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography, Ambulatory; Encainide; Flecainide; Humans; Mexiletine; Sotalol; Tachycardia; Tocainide	1992
Is pretransplant antiarrhythmic drug therapy a risk factor? Transplantation proceedings, 1992, Volume: 24, Issue:6 Topics: Adolescent; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Cause of Death; Child; Female; Follow-Up Studies; Heart Transplantation; Humans; Male; Mexiletine; Middle Aged; Postoperative Complications; Premedication; Propafenone; Quinidine; Sotalol; Survival Rate; Transplantation, Heterotopic	1992
Sotalol and mexiletine: combination of rate-dependent electrophysiological effects. Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:4 Topics: Action Potentials; Animals; Diastole; Dogs; Drug Combinations; Electrophysiology; Female; Male; Mexiletine; Purkinje Fibers; Sotalol	1990
The cellular electropharmacology of mexiletine combined with sotalol in porcine papillary muscle and Purkinje fibre. I. Alteration of mexiletine-induced Vmax depression. The Canadian journal of cardiology, 1990, Volume: 6, Issue:9 Topics: Action Potentials; Animals; Electrophysiology; Female; In Vitro Techniques; Male; Mexiletine; Papillary Muscles; Purkinje Fibers; Receptors, Drug; Sodium Channels; Sotalol; Swine	1990
The cellular electropharmacology of mexiletine combined with sotalol in porcine papillary muscle and Purkinje fibre. II. Effects on action potential duration and refractoriness. The Canadian journal of cardiology, 1990, Volume: 6, Issue:9 Topics: Action Potentials; Animals; Electrophysiology; Female; Male; Mexiletine; Papillary Muscles; Purkinje Fibers; Refractory Period, Electrophysiological; Sodium Channels; Sotalol; Swine; Time Factors	1990
Experimental evidence for the antiarrhythmic action of indoramin. Journal of cardiovascular pharmacology, 1986, Volume: 8 Suppl 2 Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Coronary Vessels; Electrocardiography; Guinea Pigs; Heart; Heart Rate; Indoles; Indoramin; Mexiletine; Myocardial Contraction; Prazosin; Rats; Sotalol	1986
A comparison of the cellular electrophysiology of mexiletine and sotalol, singly and combined, in canine Purkinje fibers. Journal of cardiovascular pharmacology, 1988, Volume: 12, Issue:3 Topics: Action Potentials; Animals; Dogs; Evoked Potentials; Heart Conduction System; In Vitro Techniques; Mexiletine; Purkinje Fibers; Sotalol	1988
Arrhythmogenesis--a European perspective. The American journal of cardiology, 1987, Apr-30, Volume: 59, Issue:11 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Utilization; Europe; Humans; Mexiletine; Sotalol; United States	1987
Investigations into the bradycardic action of indoramin. Arzneimittel-Forschung, 1985, Volume: 35, Issue:1A Topics: Animals; Blood Pressure; Cats; Coronary Circulation; Electrocardiography; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Indoles; Indoramin; Male; Mexiletine; Myocardial Contraction; Sotalol	1985
Mexiletine antagonizes effects of sotalol on QT interval duration and its proarrhythmic effects in a canine model of torsade de pointes. Journal of the American College of Cardiology, 1995, Volume: 26, Issue:3 Topics: Analysis of Variance; Animals; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Combination; Electrocardiography; Electrophysiology; Mexiletine; Sotalol; Torsades de Pointes	1995
Antiarrhythmic effect of a sotalol-mexiletine combination on induced ventricular tachycardia in dogs. Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:2 Topics: Animals; Coronary Vessels; Dogs; Drug Combinations; Electric Stimulation; Electrocardiography; Electrophysiology; Hemodynamics; Mexiletine; Myocardial Infarction; Refractory Period, Electrophysiological; Sotalol; Tachycardia, Ventricular	1993
Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome. Circulation, 1997, Sep-16, Volume: 96, Issue:6 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benz(a)Anthracenes; Dogs; Electrocardiography; Heart Conduction System; Heart Rate; Intercellular Signaling Peptides and Proteins; Long QT Syndrome; Mexiletine; Mutagens; Pacemaker, Artificial; Peptides; Phenotype; Sodium Channel Blockers; Sotalol; Torsades de Pointes	1997
Effects of sodium channel block with mexiletine to reverse action potential prolongation in in vitro models of the long term QT syndrome. Journal of cardiovascular electrophysiology, 1997, Volume: 8, Issue:11 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Long QT Syndrome; Male; Mexiletine; Sodium Channel Blockers; Sotalol	1997
Scavenger effect of experimental and clinically used cardiovascular drugs. Journal of cardiovascular pharmacology, 2001, Volume: 38, Issue:5 Topics: Anti-Arrhythmia Agents; Antioxidants; Carbazoles; Cardiovascular Agents; Carvedilol; Erythrocytes; Free Radical Scavengers; Humans; Indoles; Male; Methylphenazonium Methosulfate; Mexiletine; Propanolamines; Pyrroles; Sotalol	2001
The cellular electrophysiologic effect of a new amiodarone like antiarrhythmic drug GYKI 16638 in undiseased human ventricular muscle: comparison with sotalol and mexiletine. Current medicinal chemistry, 2002, Volume: 9, Issue:1 Topics: Action Potentials; Adult; Amiodarone; Anti-Arrhythmia Agents; Electric Stimulation; Electrophysiology; Female; Heart; Humans; In Vitro Techniques; Kinetics; Male; Mexiletine; Papillary Muscles; Phenethylamines; Sotalol; Sulfonamides; Ventricular Function, Right	2002
Long-term follow-up of sudden cardiac arrest survivors and electrophysiologically guided antiarrhythmic therapy. Cardiology, 2003, Volume: 99, Issue:4 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Defibrillators, Implantable; Electrophysiologic Techniques, Cardiac; Female; Follow-Up Studies; Heart Arrest; Humans; Male; Mexiletine; Middle Aged; Prognosis; Propafenone; Sotalol; Survivors; Time Factors; Treatment Outcome	2003
Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Mar-01, Volume: 847, Issue:2 Topics: Amiodarone; Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carbazoles; Carvedilol; Chromatography, Liquid; Diltiazem; Humans; Metoprolol; Mexiletine; Molecular Structure; Propanolamines; Propranolol; Reproducibility of Results; Sotalol; Tandem Mass Spectrometry; Verapamil	2007
Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks. Pacing and clinical electrophysiology : PACE, 2011, Volume: 34, Issue:12 Topics: Acetanilides; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Cohort Studies; Defibrillators, Implantable; Drug Therapy, Combination; Electric Countershock; Electrocardiography; Female; Humans; Hypoglycemia; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Ischemia; Piperazines; Ranolazine; Sotalol; Stroke Volume; Tachycardia, Ventricular; Treatment Outcome	2011
Wide QRS Tachycardia in a young patient. Archives of internal medicine, 2012, Apr-09, Volume: 172, Issue:7 Topics: Anti-Arrhythmia Agents; Arrhythmogenic Right Ventricular Dysplasia; Blood Pressure; Defibrillators, Implantable; Diagnosis, Differential; Drug Therapy, Combination; Electric Countershock; Electrocardiography; Heart Conduction System; Heart Rate; Humans; Male; Metoprolol; Mexiletine; Sotalol; Tachycardia; Treatment Outcome; Young Adult	2012
ECG of the month. Ventricular arrhythmia in a dog. Journal of the American Veterinary Medical Association, 2013, Aug-01, Volume: 243, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Dog Diseases; Dogs; Electrocardiography; Fatal Outcome; Female; Mexiletine; Sotalol; Tachycardia, Ventricular; Ventricular Premature Complexes	2013
Combination drug therapy for patients with intractable ventricular tachycardia associated with right ventricular cardiomyopathy. Pacing and clinical electrophysiology : PACE, 2014, Volume: 37, Issue:1 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmogenic Right Ventricular Dysplasia; Chronic Disease; Drug Therapy, Combination; Female; Flecainide; Humans; Male; Mexiletine; Retrospective Studies; Sotalol; Tachycardia, Ventricular; Treatment Failure; Treatment Outcome	2014
Use of Antiarrhythmic Medications in Medicare Part D Patients With an Implantable Cardioverter-Defibrillator and Ventricular Tachycardia. The American journal of cardiology, 2017, 05-01, Volume: 119, Issue:9 Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Databases, Factual; Death, Sudden, Cardiac; Defibrillators, Implantable; Electric Countershock; Female; Humans; Logistic Models; Male; Medicare Part D; Mexiletine; Ranolazine; Sodium Channel Blockers; Sotalol; Tachycardia, Ventricular; United States	2017