Page last updated: 2024-08-16

sotalol and e 4031

sotalol has been researched along with e 4031 in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's21 (80.77)18.2507
2000's4 (15.38)29.6817
2010's1 (3.85)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bagli, JF; Ellingboe, JW; Kitzen, JM; Moubarak, IF; Nguyen, TT; Parsons, RW; Spinelli, W; Von Engen, D; Winkley, MW1
Anantharaman, V; Bagli, JF; Butera, JA; Cullinan, C; Marcopulos, N; Moubarak, IF; Parsons, RW; Spinelli, W1
Kanojia, RM; Kauffman, J; Salata, JJ1
Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B1
Colatsky, TJ; Parsons, RW; Spinelli, W1
Grundke, M; Ravens, U; Wettwer, E1
Baskin, EP; Cingolani, HE; Lynch, JJ; Stein, RB; Wiedmann, RT1
Baskin, EP; Brookes, LM; Claremon, DA; Lynch, JJ; Selnick, HG; Serik, CM; Wallace, AA1
Brookes, LM; Claremon, DA; Lynch, JJ; Selnick, HG; Stupienski, RF; Wallace, AA1
Hanaki, Y; Ozawa, T; Sano, T; Shimada, Y; Sugiyama, S; Taki, K1
Brunden, MN; Buchanan, LV; Gibson, JK; Kabell, G1
Krafte, DS; Volberg, WA1
Kane, KA; McIntosh, MA; Pacini, D; Tanira, M1
Baskin, EP; Lynch, JJ1
Inoue, H; Saihara, S; Sugimoto, T; Usui, M1
Baskin, EP; Guinosso, PJ; Hamill, T; Lynch, JJ; Nutt, EM; Salata, JJ; Woods, CM1
Hara, Y; Masuda, Y; Mori, K; Nakaya, H; Saito, T1
MacKenzie, I; Saville, VL; Waterfall, JF1
Colatsky, TJ; Moubarak, IF; Parsons, RW; Spinelli, W1
Ishii, K; Taira, N; Yamagishi, T1
Lee, EW; Lee, KS; Tsai, TD1
Mitamura, H; Ogawa, S; Okada, Y; Sadanaga, T1
Feng, J; Li, GR; Nattel, S; Wang, Z1
Baláti, B; Csaba, L; Iost, N; Lathrop, DA; Papp, JG; Takács, J; Tálosi, L; Varro, A; Virág, L1
Charpentier, F; Debailleul, M; Gerlach, U; Le Marec, H; Mérot, J; Moise, NS; Probst, V1

Trials

1 trial(s) available for sotalol and e 4031

ArticleYear
Assessment of reverse use-dependent blocking actions of class III antiarrhythmic drugs by 24-hour Holter electrocardiography.
    Journal of the American College of Cardiology, 1996, Volume: 27, Issue:1

    Topics: Adult; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Electrocardiography, Ambulatory; Female; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Piperidines; Pyridines; Pyrimidinones; Regression Analysis; Sotalol; Statistics, Nonparametric; Sulfonamides

1996

Other Studies

25 other study(ies) available for sotalol and e 4031

ArticleYear
Class III antiarrhythmic activity of novel substituted 4-[(methylsulfonyl)amino]benzamides and sulfonamides.
    Journal of medicinal chemistry, 1992, Feb-21, Volume: 35, Issue:4

    Topics: Action Potentials; Anti-Arrhythmia Agents; Atrial Function; Benzamides; Benzimidazoles; Biological Availability; Electric Conductivity; Heart Atria; Heart Conduction System; Heart Ventricles; Membrane Potentials; Molecular Structure; Myocardial Contraction; Purkinje Fibers; Structure-Activity Relationship; Sulfanilamides; Sulfonamides; Ventricular Fibrillation; Ventricular Function

1992
Synthesis and selective class III antiarrhythmic activity of novel N-heteroaralkyl-substituted 1-(aryloxy)-2-propanolamine and related propylamine derivatives.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:11

    Topics: Animals; Anti-Arrhythmia Agents; Cats; Dogs; Electrophysiology; Guinea Pigs; Membrane Potentials; Propanolamines; Propylamines; Purkinje Fibers; Quinolines; Structure-Activity Relationship

1991
Synthesis and class III type antiarrhythmic activity of 4-aroyl (and aryl)-l-aralkylpiperazines.
    Bioorganic & medicinal chemistry letters, 2000, Dec-18, Volume: 10, Issue:24

    Topics: Animals; Anti-Arrhythmia Agents; Biological Assay; Ferrets; In Vitro Techniques; Isometric Contraction; Male; Papillary Muscles; Piperazines; Piperidines; Structure-Activity Relationship

2000
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:11

    Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG

2008
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

    Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers

2012
Effects of WAY-123,398, a new class III antiarrhythmic agent, on cardiac refractoriness and ventricular fibrillation threshold in anesthetized dogs: a comparison with UK-68798, E-4031, and dl-sotalol.
    Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:6

    Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Benzimidazoles; Dogs; Electrocardiography; Electrophysiology; Female; Heart; Heart Conduction System; Hemodynamics; In Vitro Techniques; Male; Phenethylamines; Piperidines; Purkinje Fibers; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfanilamides; Sulfonamides; Ventricular Fibrillation

1992
Differential effects of the new class III antiarrhythmic agents almokalant, E-4031 and D-sotalol, and of quinidine, on delayed rectifier currents in guinea pig ventricular myocytes.
    Cardiovascular research, 1992, Volume: 26, Issue:11

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; In Vitro Techniques; Muscles; Piperidines; Potassium; Potassium Channels; Propanolamines; Pyridines; Quinidine; Sotalol; Time Factors

1992
Myocardial contractile behavior of a new sotalol derivative.
    Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Depression, Chemical; Dogs; Electrocardiography; Female; Male; Muscle Relaxation; Myocardial Contraction; Papillary Muscles; Piperidines; Pyridines; Rabbits; Sotalol

1991
Effects of new and potent methanesulfonanilide class III antiarrhythmic agents on myocardial refractoriness and contractility in isolated cardiac muscle.
    Journal of cardiovascular pharmacology, 1991, Volume: 18, Issue:3

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Ferrets; Heart; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Phenethylamines; Piperidines; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides; Temperature

1991
Cardiac electrophysiologic and inotropic actions of new and potent methanesulfonanilide class III antiarrhythmic agents in anesthetized dogs.
    Journal of cardiovascular pharmacology, 1991, Volume: 18, Issue:5

    Topics: Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiology; Female; Heart; Hemodynamics; Male; Myocardial Contraction; Phenethylamines; Piperidines; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides

1991
Effects of antiarrhythmic agents classified as class III group on ischaemia-induced myocardial damage in canine hearts.
    British journal of pharmacology, 1990, Volume: 99, Issue:3

    Topics: Acetylglucosaminidase; Amiodarone; Anesthesia; Animals; Anti-Arrhythmia Agents; Blood Pressure; Coronary Disease; Coronary Vessels; Dogs; Electrocardiography; Female; Heart Rate; In Vitro Techniques; Lysosomes; Male; Mitochondria, Heart; Piperidines; Pyridines; Sotalol

1990
Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia.
    Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Heart Conduction System; Heart Rate; Male; Methoxamine; Phenethylamines; Piperidines; Pyridines; Quaternary Ammonium Compounds; Rabbits; Software; Sotalol; Sulfonamides; Torsades de Pointes

1993
Voltage dependence of cardiac delayed rectifier block by methanesulfonamide class III antiarrhythmic agents.
    Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:1

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Phenethylamines; Piperidines; Procainamide; Pyridines; Sotalol; Stereoisomerism; Sulfonamides; Ventricular Function

1994
Comparison of the cardiac electrophysiologic effects of NE-10064 with sotalol and E-4031 and their modification by simulated ischaemia.
    Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Myocardial Ischemia; Piperazines; Piperidines; Purkinje Fibers; Pyridines; Sheep; Sotalol

1994
Comparative effects of increased extracellular potassium and pacing frequency on the class III activities of methanesulfonanilide IKr blockers dofetilide, D-sotalol, E-4031, and MK-499.
    Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Electric Stimulation; Ferrets; Male; Phenethylamines; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides

1994
Antifibrillatory effects of class III antiarrhythmic drugs: comparative study with flecainide.
    Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:3

    Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Dogs; Electric Stimulation; Flecainide; Heart Conduction System; Piperidines; Pyridines; Sotalol; Ventricular Fibrillation

1993
Comparison of binding to rapidly activating delayed rectifier K+ channel, IKr, and effects on myocardial refractoriness for class III antiarrhythmic agents.
    Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Binding, Competitive; Chromans; Electrophysiology; Guinea Pigs; Heart Ventricles; Papillary Muscles; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Procainamide; Pyridines; Sotalol; Structure-Activity Relationship; Sulfonamides; Tritium

1995
Anticholinergic effects of class III antiarrhythmic drugs in guinea pig atrial cells. Different molecular mechanisms.
    Circulation, 1995, Jun-01, Volume: 91, Issue:11

    Topics: Acetylcholine; Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Atrial Function, Left; Cells, Cultured; Guinea Pigs; Heart Atria; In Vitro Techniques; Myocardial Contraction; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines; Pyrimidinones; Receptors, Muscarinic; Sotalol

1995
Differential class III and glibenclamide effects on action potential duration in guinea-pig papillary muscle during normoxia and hypoxia/ischaemia.
    British journal of pharmacology, 1993, Volume: 110, Issue:2

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrophysiology; Glyburide; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Microelectrodes; Myocardial Ischemia; Papillary Muscles; Piperidines; Potassium Channels; Pyrazines; Pyridines; Sotalol

1993
Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes.
    Cardiovascular research, 1993, Volume: 27, Issue:9

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzimidazoles; Cats; Cells, Cultured; Culture Techniques; Dogs; Dose-Response Relationship, Drug; Myocardium; Phenethylamines; Piperidines; Potassium Channels; Purkinje Fibers; Pyridines; Sotalol; Sulfanilamides; Sulfonamides

1993
Absence of effects of class III antiarrhythmic agents on cloned cardiac K channels.
    Japanese journal of pharmacology, 1993, Volume: 61, Issue:4

    Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Cloning, Molecular; Electrophysiology; Myocardium; Oocytes; Piperidines; Potassium Channels; Pyridines; Pyrimidinones; Quinidine; Sotalol; Xenopus laevis

1993
Membrane activity of class III antiarrhythmic compounds; a comparison between ibutilide, d-sotalol, E-4031, sematilide and dofetilide.
    European journal of pharmacology, 1993, Mar-30, Volume: 234, Issue:1

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Phenethylamines; Piperidines; Potassium Channels; Procainamide; Pyridines; Sotalol; Sulfonamides

1993
Effects of class III antiarrhythmic drugs on transient outward and ultra-rapid delayed rectifier currents in human atrial myocytes.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:1

    Topics: Aminobenzoates; Anti-Arrhythmia Agents; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Heart Atria; Humans; Middle Aged; Piperidines; Potassium Channels; Pyridines; Sotalol

1997
The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre repolarization.
    The Journal of physiology, 2000, Feb-15, Volume: 523 Pt 1

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzodiazepines; Chromans; Delayed Rectifier Potassium Channels; Dogs; Electrophysiology; Female; Male; Papillary Muscles; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Purkinje Fibers; Pyridines; Sotalol; Sulfonamides

2000
Electropharmacological characterization of cardiac repolarization in German shepherd dogs with an inherited syndrome of sudden death: abnormal response to potassium channel blockers.
    Journal of the American College of Cardiology, 2000, Volume: 36, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chromans; Death, Sudden, Cardiac; Dog Diseases; Dogs; Electrocardiography; Endocardium; Heart; In Vitro Techniques; Myocardium; Piperidines; Potassium Channel Blockers; Purkinje Fibers; Pyridines; Reference Values; Sotalol; Sulfonamides

2000