sorbitol has been researched along with sorbinil in 94 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 58 (61.70) | 18.7374 |
1990's | 30 (31.91) | 18.2507 |
2000's | 5 (5.32) | 29.6817 |
2010's | 1 (1.06) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Fukushi, S; Kador, P; Kinoshita, JH; Merola, LO | 1 |
Aldinger, CE; MacDonald, DP; Peterson, MJ; Sarges, R | 1 |
Edmands, S; Yancey, PH | 1 |
Cammarata, PR; Chen, HQ; Yang, J; Yorio, T | 2 |
Aperia, A; Celsi, G; Eklöf, AC; Körner, A; Linné, T; Persson, B | 1 |
Aldinger, CE; Beyer, TA; Bordner, J; Burdi, DF; Bussolotti, DL; Inskeep, PB; Lipinski, CA; Siegel, TW | 1 |
Greene, DA; Nathaniel, V; Sima, AA | 1 |
Lowitt, S; Malone, JI | 1 |
Flam, BR; Sawicki, DR; Sredy, J | 1 |
Wasada, T | 1 |
Futterweit, S; Hammer, E; Oates, P; Siegel, TW; Trachtman, H | 1 |
Kato, K; Miwa, I; Mizota, M; Nakayama, K; Okuda, J | 1 |
Brennan, MC; Del Monte, MA; Diaz, TC; Greene, DA; Lattimer, SA; Nakamura, J; Rabbani, R | 1 |
Tagashira, E; Yoneta, T | 1 |
Cook, WR; Lowitt, S; Malone, JI | 1 |
Hamprecht, B; Thiess, U; Wiesinger, H | 1 |
Brenner, RM; Gullans, SR; Heilig, CW; Kone, BC; Yu, AS | 1 |
Greene, DA | 1 |
Robinson, JP; Tomlinson, DR; Willars, GB | 1 |
Barr, CC | 1 |
Calthrop-Owen, EF; Tomlinson, DR; Willars, GB | 1 |
Dunlap, JA; Yorek, MA | 1 |
Plurad, SB; Schmidt, RE; Sherman, WR; Tilton, RG; Williamson, JR | 1 |
Craven, PA; DeRubertis, FR | 1 |
Chang, K; Eades, DM; Kilo, C; Province, MA; Pugliese, G; Sherman, WR; Tilton, RG; Williamson, JR | 1 |
Azar, S; Brown, DM; Mauer, SM; Steffes, MW | 1 |
Bitensky, MW; Buican, T; Dembo, M; Keaton, PA; Kowluru, A; Kowluru, R | 1 |
Li, WY | 1 |
Ashton, MA; Beyer, TA; Goddu, KJ; Hutson, NJ; Rafford, CE; Yeh, LA | 1 |
Fujimori, S; Hirata, Y; Okada, K | 1 |
Gonzalez, AM; Hothersall, JS; McLean, P; Sochor, M | 1 |
Mayer, JH; Tomlinson, DR | 1 |
Greene, DA; Lattimer, SA | 1 |
MacGregor, LC; Matschinsky, FM | 2 |
Cohen, M | 1 |
Cheng, HM; González, RG | 1 |
Peterson, MJ; Sarges, R | 1 |
Akagi, Y; Kador, PF; Kinoshita, JH | 1 |
Beyer, TA; Hutson, NJ; Rafford, CE; Yeh, LA | 1 |
Collier, J; Gundersen, K; Mehta, DJ; Peterson, MJ; Pitts, NE; Shaw, GL; Vreeland, F | 1 |
Odom, JD; Williams, WF | 1 |
Baar, S; Bareford, D; Barnett, AH; Jennings, PE; Stone, PC; Stuart, J | 1 |
Boss, GR; Lane, MJ; Lorenzi, M; Montisano, DF; Toledo, S | 1 |
Clarke, BF; Ewing, DJ; Martyn, CN; Reid, W; Young, RJ | 1 |
Dyck, PJ; Karnes, JL; Minnerath, SR; Poduslo, JF; Vilen, TH; Yao, JK; Zimmerman, BR | 1 |
Bril, V; Brown, MB; Greene, DA; Lattimer, SA; McEwen, TA; Nathaniel, V; Sima, AA | 1 |
Ross, IS; Whiting, PH | 1 |
Lerman, S; Moran, M | 1 |
Dunlap, JA; Ginsberg, BH; Yorek, MA | 1 |
Halonen, T; Hyvönen, SK; Kilpeläinen, H; Lehtinen, JM; Puhakainen, E; Uusitupa, M | 1 |
Cohen, MP; Dasmahapatra, A; Robey, C; Suarez, S | 1 |
Beyer-Mears, A; Cruz, E | 1 |
Burgess, SE; Cheng, H; Crabbe, MJ; Petchey, M | 1 |
Kador, PF; Kinoshita, JH; Sharpless, NE | 1 |
Das, B; Hair, GA; Srivastava, SK | 1 |
Khatami, M; Li, W; Rockey, JH | 1 |
Crabbe, MJ; Lloyd, P | 1 |
Ackermann, KE; Chang, K; Kilo, C; Marvel, J; Rowold, E; Sherman, WR; Tomlinson, M; Williamson, JR | 1 |
Mayer, JH; Moriarty, RJ; Tomlinson, DR | 1 |
Cobo, LM; Cogan, DG; Datilis, MB; Kador, PF; Kinoshita, JH; Kupfer, C; Robison, G | 1 |
Clarke, BF; Ewing, DJ; Martyn, CN; Young, RJ | 1 |
Cotlier, E; Hollander, JD; Jacobson, M; Sharma, YR | 1 |
Bernstein, M; Finegold, D; Greene, DA; Lattimer, SA; Nolle, S | 1 |
Gillon, KR; Hawthorne, JN; Tomlinson, DR | 1 |
Beyer-Mears, A; Cohen, MP; Ku, L | 1 |
Handelsman, DJ; Hanwell, MA; Satchell, PM; Turtle, JR; Yue, DK | 1 |
Lomecky-Janousek, MZ; Popp-Snijders, C; Schouten, JA; van der Veen, EA | 1 |
Aldinger, CE; Leavengood, H; Malone, JI; O'Brien, MM; Page, MG; Peterson, MJ | 1 |
Catiles, M; Kador, P; Kinoshita, JH | 1 |
Hanwell, MA; Satchell, PM; Turtle, JR; Yue, DK | 1 |
Gillon, KR; Hawthorne, JN | 1 |
Martin, DB; Simmons, DA; Winegrad, AI | 1 |
Albrecht, BN; Florkiewicz, RZ; Lowe, WL; Spanheimer, RG; Yorek, MA | 1 |
Chang, K; Corbett, JA; Currie, MG; Hasan, KS; McDaniel, ML; Misko, TP; Moore, WM; Petrash, JM; Smith, SR; Tilton, RG | 1 |
Cohen, RA; Palacino, JJ; Tesfamariam, B; Weisbrod, RM | 1 |
Greene, DA; Lattimer, SA; Nakamura, J | 1 |
Bleyer, AJ; Fumo, P; Goldfarb, S; Simmons, DA; Snipes, ER; Ziyadeh, FN | 1 |
Greene, DA; Henry, DN; Killen, PD; Stevens, MJ; Thomas, TP | 1 |
Kozak, WM; Lowitt, S; Malone, JI; Orfalian, Z; Salem, A | 1 |
Greene, DA; Kamijo, M; Lattimer, SA; Sima, AA; Stevens, MJ; Van Huysen, C | 1 |
Lowe, WL; Matsushita, K; Stokes, JB; Wiese, TJ; Yorek, MA | 1 |
Chakir, M; Plante, GE | 1 |
Beyer-Mears, A; Cruz, E; Diecke, FP; Mistry, K | 1 |
Brown, TR; Kappler, F; Lal, S; Randall, WC; Szwergold, BS; Taylor, AH; Walker, M | 1 |
Eichberg, J; Kuruvilla, R | 1 |
Morrisey, K; Phillips, AO; Steadman, R; Williams, JD | 1 |
Fathallah, L; Obrosova, IG | 1 |
Lang, HJ; Obrosova, IG; Stevens, MJ | 1 |
Bhatnagar, A; Chandra, D; Jackson, EB; Kelley, R; Ramana, KV; Srivastava, SK | 1 |
Asnaghi, V; Dagher, Z; Gerhardinger, C; Hoehn, T; Lorenzi, M; Park, YS | 1 |
Bhatnagar, A; Kaiserova, K; Srivastava, S; Tang, XL | 1 |
Huang, Q; Liu, Q; Ouyang, D | 1 |
5 review(s) available for sorbitol and sorbinil
Article | Year |
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Aldose reductase in diabetic complications of the eye.
Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Chromans; Cornea; Diabetes Complications; Diabetic Retinopathy; Epithelium; Eye Diseases; Female; Galactitol; Galactose; Humans; Imidazoles; Imidazolidines; Lens, Crystalline; Mice; Mice, Obese; NADP; Polymers; Pregnancy; Rats; Regeneration; Retina; Rodentia; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Xylitol | 1979 |
Diabetic retinopathy.
Topics: Adult; Aldehyde Reductase; Aneurysm; Capillaries; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Edema; Humans; Imidazoles; Imidazolidines; Laser Therapy; Neovascularization, Pathologic; Retinal Diseases; Retinal Vessels; Sorbitol; Vitrectomy | 1986 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; Corneal Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Fluorenes; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Models, Molecular; Naphthalenes; Phthalazines; Rhodanine; Sorbitol; Structure-Activity Relationship; Substrate Specificity; Sugar Alcohol Dehydrogenases; Thiazolidines; Tissue Distribution | 1985 |
NIH conference. Aldose reductase and complications of diabetes.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Cataract; Corneal Diseases; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Galactosemias; Humans; Imidazoles; Imidazolidines; Lens, Crystalline; Osmolar Concentration; Peripheral Nerves; Rats; Sorbitol; Structure-Activity Relationship; Sugar Alcohol Dehydrogenases | 1984 |
Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications.
Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructose; Humans; Hypoglycemic Agents; Imidazolidines; Oxidative Stress; Sorbitol | 2019 |
9 trial(s) available for sorbitol and sorbinil
Article | Year |
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Peripheral nerve repair following ARI treatment.
Topics: Aldehyde Reductase; Axons; Diabetic Neuropathies; Double-Blind Method; Humans; Imidazoles; Imidazolidines; Nerve Regeneration; Neurons; Peripheral Nervous System Diseases; Ranvier's Nodes; Sorbitol | 1991 |
Clinical experience with sorbinil--an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Autonomic Nervous System Diseases; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Diabetic Neuropathies; Diabetic Retinopathy; Double-Blind Method; Humans; Imidazoles; Imidazolidines; Pain; Rats; Sorbitol; Sugar Alcohol Dehydrogenases | 1986 |
Six-month treatment with sorbinil in asymptomatic diabetic neuropathy. Failure to improve abnormal nerve function.
Topics: Adult; Aldehyde Reductase; Autonomic Nervous System; Clinical Trials as Topic; Diabetic Neuropathies; Double-Blind Method; Female; Heart Rate; Humans; Imidazoles; Imidazolidines; Male; Middle Aged; Motor Neurons; Neurons, Afferent; Peripheral Nerves; Random Allocation; Sorbitol; Sugar Alcohol Dehydrogenases | 1987 |
Regeneration and repair of myelinated fibers in sural-nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil.
Topics: Action Potentials; Aldehyde Reductase; Biopsy; Clinical Trials as Topic; Demyelinating Diseases; Diabetic Neuropathies; Double-Blind Method; Humans; Imidazoles; Imidazolidines; Nerve Fibers; Nerve Regeneration; Neural Conduction; Random Allocation; Sorbitol; Sugar Alcohol Dehydrogenases; Sural Nerve | 1988 |
The effect of sorbinil treatment on red cell sorbitol levels and clinical and electrophysiological parameters of diabetic neuropathy.
Topics: Adult; Clinical Trials as Topic; Diabetic Neuropathies; Double-Blind Method; Erythrocytes; Female; Humans; Imidazoles; Imidazolidines; Male; Middle Aged; Neural Conduction; Peripheral Nerves; Random Allocation; Sorbitol | 1986 |
The penetration of Sorbinil, an aldose reductase inhibitor, into lens, aqueous humour and erythrocytes of patients undergoing cataract extraction.
Topics: Aged; Aldehyde Reductase; Aqueous Humor; Cataract Extraction; Chromatography, High Pressure Liquid; Diabetes Mellitus; Erythrocytes; Female; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; Middle Aged; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
Aldose reductase inhibition in diabetes.
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Erythrocytes, Abnormal; Humans; Imidazoles; Imidazolidines; Rats; Sorbitol; Sugar Alcohol Dehydrogenases | 1984 |
myo-Inositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment.
Topics: Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Double-Blind Method; Erythrocytes; Female; Gas Chromatography-Mass Spectrometry; Humans; Imidazoles; Imidazolidines; Inositol; Male; Middle Aged; Sorbitol; Sugar Alcohol Dehydrogenases | 1984 |
Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects.
Topics: Administration, Oral; Adolescent; Adult; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Erythrocytes; Hemoglobin A; Humans; Imidazoles; Imidazolidines; Male; Polymers; Rats; Rats, Inbred Strains; Sorbitol | 1984 |
80 other study(ies) available for sorbitol and sorbinil
Article | Year |
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CP-45,634: a novel aldose reductase inhibitor that inhibits polyol pathway activity in diabetic and galactosemic rats.
Topics: Aldehyde Reductase; Animals; Benzopyrans; Cataract; Chromans; Diabetes Mellitus, Experimental; Galactitol; Galactose; Galactosemias; Imidazoles; Imidazolidines; Kinetics; Lens, Crystalline; Male; Polymers; Rats; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1979 |
Effects on rat renal osmolytes of extended treatment with an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Betaine; Body Weight; Imidazoles; Imidazolidines; Kidney; Male; Osmolar Concentration; Rats; Rats, Wistar; Sorbitol; Time Factors; Urine | 1992 |
Modulation of myo-[3H]inositol uptake by glucose and sorbitol in cultured bovine lens epithelial cells. I. Restoration of myo-inositol uptake by aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Biological Transport; Cattle; Cells, Cultured; Deoxyglucose; Epithelium; Glucose; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Meglumine; Sodium; Sorbitol | 1992 |
Modulation of myo-[3H]inositol uptake by glucose and sorbitol in cultured bovine lens epithelial cells. II. Characterization of high- and low-affinity myo-inositol transport sites.
Topics: Aldehyde Reductase; Animals; Binding Sites; Biological Transport; Cattle; Cells, Cultured; Epithelium; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Lens, Crystalline; Sorbitol | 1992 |
Sorbinil does not prevent hyperfiltration, elevated ultrafiltration pressure and albuminuria in streptozotocin-diabetic rats.
Topics: Albuminuria; Aldehyde Reductase; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Glomerular Filtration Rate; Imidazoles; Imidazolidines; Kidney; Kidney Cortex; Kidney Tubules, Proximal; Male; Nephrons; Rats; Rats, Inbred Strains; Reference Values; Sorbitol; Ultrafiltration | 1992 |
Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Chromans; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Glycolates; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Molecular Conformation; Molecular Structure; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Stereoisomerism; Structure-Activity Relationship; X-Ray Diffraction | 1992 |
Measurements of tissue sorbitol in diabetes mellitus: enzyme method versus gas-liquid chromatography.
Topics: Aldehyde Reductase; Analysis of Variance; Animals; Chromatography, Gas; Diabetes Mellitus; Diabetes Mellitus, Experimental; Erythrocytes; Humans; Hyperglycemia; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Spectrometry, Fluorescence; Sugar Alcohols | 1992 |
Adenosine triphosphatase activity in sciatic nerve tissue of streptozocin-induced diabetic rats with and without high dietary sucrose: effect of aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sucrose | 1991 |
[Diabetic neuropathy--pathogenesis and precipitating factors].
Topics: Alcohol Drinking; Animals; Diabetic Neuropathies; Energy Metabolism; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Risk Factors; Smoking; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1991 |
The role of polyols in cerebral cell volume regulation in hypernatremic and hyponatremic states.
Topics: Aldehyde Reductase; Analysis of Variance; Animals; Brain; Electrolytes; Hypernatremia; Hyponatremia; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sorbitol; Vasopressins; Water-Electrolyte Balance | 1991 |
Properties of novel aldose reductase inhibitors, M16209 and M16287, in comparison with known inhibitors, ONO-2235 and sorbinil.
Topics: Aldehyde Reductase; Animals; Benzofurans; Cataract; Cattle; Diabetic Neuropathies; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Rhodanine; Sorbitol; Thiazolidines | 1991 |
Sorbitol, myo-inositol, and rod outer segment phagocytosis in cultured hRPE cells exposed to glucose. In vitro model of myo-inositol depletion hypothesis of diabetic complications.
Topics: Adult; Aldehyde Reductase; Cells, Cultured; Diabetic Retinopathy; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Middle Aged; Phagocytosis; Pigment Epithelium of Eye; Rod Cell Outer Segment; Sorbitol | 1991 |
[Aldose reductase inhibitors].
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus; Flavonoids; Fructose; Glucose; Glutarates; Humans; Imidazoles; Imidazolidines; Sorbitol; Structure-Activity Relationship; Substrate Specificity | 1991 |
Nonosmotic diabetic cataracts.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Sorbitol; Streptozocin; Sugar Alcohol Dehydrogenases; Taurine | 1990 |
Sorbitol pathway activity and utilization of polyols in astroglia-rich primary cultures.
Topics: Aldehyde Reductase; Animals; Astrocytes; Cell Division; Cells, Cultured; Culture Media; DNA Replication; Energy Metabolism; Fructose; Glioma; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Neuroblastoma; Neurons; Rats; Rats, Inbred Strains; Sorbitol; Tumor Cells, Cultured; Xylitol | 1990 |
Modulation of osmolytes in MDCK cells by solutes, inhibitors, and vasopressin.
Topics: Animals; Cell Line; Glucose; Glycerylphosphorylcholine; Imidazoles; Imidazolidines; Inositol; Kidney; Phlorhizin; Sodium Chloride; Sorbitol; Vasopressins; Water-Electrolyte Balance | 1990 |
A sodium-pump defect in diabetic peripheral nerve corrected by sorbinil administration: relationship to myo-inositol metabolism and nerve conduction slowing.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Energy Metabolism; Humans; Imidazoles; Imidazolidines; Inositol; Ion Channels; Neural Conduction; Peripheral Nerves; Rats; Rats, Inbred BB; Sodium; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1986 |
Studies of sorbinil on axonal transport in streptozotocin-diabetic rats.
Topics: Animals; Axonal Transport; Blood Glucose; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazolidines; Inositol; Male; Phospholipids; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol | 1986 |
Defects of axonal transport in experimental diabetes that are unrelated to the sorbitol pathway.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Blood Glucose; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Peripheral Nerves; Phosphofructokinase-1; Rats; Rats, Inbred Strains; Sorbitol | 1987 |
The effect of elevated glucose levels on myo-inositol metabolism in cultured bovine aortic endothelial cells.
Topics: Aldehyde Reductase; Animals; Aorta; Cattle; Cell Membrane; Cells, Cultured; Endothelium, Vascular; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Phospholipids; Sorbitol | 1989 |
Effects of aldose reductase inhibitor sorbinil on neuroaxonal dystrophy and levels of myo-inositol and sorbitol in sympathetic autonomic ganglia of streptozocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Galactose; Ganglia, Sympathetic; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases | 1989 |
Sorbinil suppresses glomerular prostaglandin production in the streptozotocin diabetic rat.
Topics: 6-Ketoprostaglandin F1 alpha; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dinoprostone; Female; Fructose; Glomerular Filtration Rate; Imidazoles; Imidazolidines; Kidney; Kidney Glomerulus; Organ Size; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Reference Values; Sorbitol; Sugar Alcohol Dehydrogenases | 1989 |
Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors.
Topics: Albuminuria; Aldehyde Reductase; Animals; Cardiac Output; Diabetes Mellitus, Experimental; Fluorenes; Glomerular Filtration Rate; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Iodine Radioisotopes; Male; Naphthalenes; Rats; Rats, Inbred Strains; Reference Values; Regional Blood Flow; Serum Albumin, Bovine; Sorbitol; Strontium; Sugar Alcohol Dehydrogenases; Vascular Resistance | 1989 |
Effects of sorbinil on glomerular structure and function in long-term-diabetic rats.
Topics: Aldehyde Reductase; Animals; Basement Membrane; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dietary Proteins; Imidazoles; Imidazolidines; Kidney Cortex; Kidney Glomerulus; Male; Microscopy, Electron; Rats; Rats, Inbred Lew; Sorbitol; Streptozocin | 1989 |
Reversible sodium pump defect and swelling in the diabetic rat erythrocyte: effects on filterability and implications for microangiopathy.
Topics: Adenosine Triphosphate; Animals; Cytosol; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Erythrocyte Deformability; Erythrocyte Indices; Erythrocytes; Hematocrit; Imidazoles; Imidazolidines; Insulin; Kinetics; Male; Osmotic Fragility; Ouabain; Phosphorylation; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Sodium; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1989 |
[Abnormal inositol phospholipid metabolism as a main factor causing pericyte drop-out in diabetic retinopathy].
Topics: Aldehyde Reductase; Animals; Cattle; Cell Line; Diabetic Retinopathy; Glucose; Imidazoles; Imidazolidines; Inositol; Phosphatidylinositols; Sorbitol | 1989 |
Na+-K+-ATPase pumping activity is not directly linked to myo-inositol levels after sorbinil treatment in lenses of diabetic rats.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Glutathione; Imidazoles; Imidazolidines; Inositol; Kinetics; Lens, Crystalline; Male; Ouabain; Rats; Rats, Inbred Strains; Rubidium; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases | 1987 |
Effect of a new aldose reductase inhibitor, 8'-chloro-2',3'-dihydrospiro [pyrrolidine-3,6'(5'H)-pyrrolo[1,2,3-de] [1,4]benzoxazine]-2,5,5'- trione (ADN-138), on delayed motor nerve conduction velocity in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Motor Neurons; Neural Conduction; Oxazines; Pyrroles; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases | 1988 |
Lens metabolism and cellular effects of aldose reductase.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazolidines; Lens, Crystalline; Rats; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
Axonal transport and nerve conduction velocity in animal models of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazolidines; Inositol; Motor Neurons; Neural Conduction; Rats; Sorbitol | 1985 |
Recent advances in the therapy of diabetic peripheral neuropathy by means of an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Biological Transport; Diabetic Neuropathies; Humans; Imidazoles; Imidazolidines; Inositol; Neural Conduction; Peripheral Nerves; Peripheral Nervous System Diseases; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
Experimental diabetes mellitus impairs the function of the retinal pigmented epithelium.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; Glucose; Imidazoles; Imidazolidines; Inositol; Pigment Epithelium of Eye; Rabbits; Rats; Retina; Sodium; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1986 |
Aldose reductase inhibition, glomerular metabolism, and diabetic nephropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Imidazoles; Imidazolidines; Inositol; Kidney Glomerulus; Rats; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
The effect of high glucose and oxidative stress on lens metabolism, aldose reductase, and senile cataractogenesis.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Cataract; Cell Membrane; Diabetes Complications; Glucose; Glycerophosphates; Humans; Imidazoles; Imidazolidines; Lens, Crystalline; Magnetic Resonance Spectroscopy; NADP; Oxidation-Reduction; Rats; Sorbitol; Sugar Alcohol Dehydrogenases | 1986 |
Sorbinil: a member of the novel class of spirohydantoin aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Chemical Phenomena; Chemistry; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Rats; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1986 |
The effect of aldose reductase and its inhibition on sugar cataract formation.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Lens, Crystalline; Mice; NADP; Osmotic Pressure; Oxidation-Reduction; Rabbits; Rats; Rodentia; Sorbitol; Sugar Alcohol Dehydrogenases | 1986 |
Effects of the aldose reductase inhibitor sorbinil on the isolated cultured rat lens.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Hyperglycemia; Imidazoles; Imidazolidines; Lens, Crystalline; Male; Organ Culture Techniques; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases; Xylitol | 1986 |
Study of aldose reductase inhibition in intact lenses by 13C nuclear magnetic resonance spectroscopy.
Topics: Acetaminophen; Aldehyde Reductase; Animals; Ibuprofen; Imidazoles; Imidazolidines; Lens, Crystalline; Magnetic Resonance Spectroscopy; Naphthalenes; Organ Culture Techniques; Rabbits; Sorbitol; Sugar Alcohol Dehydrogenases | 1986 |
Effects of hyperglycaemia and sorbitol accumulation on erythrocyte deformability in diabetes mellitus.
Topics: Adult; Aged; Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocyte Deformability; Female; Glucose; Humans; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Middle Aged; Osmolar Concentration; Sorbitol | 1986 |
The polyol pathway and glucose 6-phosphate in human endothelial cells cultured in high glucose concentrations.
Topics: Aldehyde Reductase; Cell Division; Cells, Cultured; Chromatography, Gas; Chromatography, High Pressure Liquid; Endothelium; Glucose; Glucose-6-Phosphate; Glucosephosphates; Glycosylation; Humans; Imidazoles; Imidazolidines; Sorbitol; Sugar Alcohols; Xylitol | 1987 |
Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Diabetes Mellitus; Diabetic Neuropathies; Erythrocytes; Female; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Male; Middle Aged; Myelin Sheath; Nerve Regeneration; Nerve Tissue; Sorbitol; Sural Nerve | 1988 |
Increased nerve polyol levels in experimental diabetes and their reversal by Sorbinil.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Time Factors | 1988 |
Sorbitol generation and its inhibition by Sorbinil in the aging normal human and rabbit lens and human diabetic cataracts.
Topics: Adolescent; Adult; Aged; Animals; Cataract; Child; Child, Preschool; Humans; Imidazoles; Imidazolidines; Lens, Crystalline; Magnetic Resonance Spectroscopy; Middle Aged; Rabbits; Sorbitol | 1988 |
Effect of sorbinil on myo-inositol metabolism in cultured neuroblastoma cells exposed to increased glucose levels.
Topics: Animals; Cell Line; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Mice; Neuroblastoma; Sorbitol; Tumor Cells, Cultured | 1988 |
Sorbinil partially prevents decreased erythrocyte deformability in experimental diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Experimental; Erythrocyte Deformability; Erythrocytes; Imidazoles; Imidazolidines; Male; Rats; Sorbitol | 1987 |
Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Microscopy, Electron, Scanning; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
Treatment with aldose reductase inhibitor or with myo-inositol arrests deterioration of the electroretinogram of diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Electrophysiology; Imidazoles; Imidazolidines; Inositol; Male; Pigment Epithelium of Eye; Rats; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
Activated and unactivated forms of human erythrocyte aldose reductase.
Topics: Aldehyde Reductase; Diabetes Mellitus; Enzyme Activation; Erythrocytes; Glucose; Glyceraldehyde; Humans; Imidazoles; Imidazolidines; Isoquinolines; Kinetics; NADP; Quercetin; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
The effects of glucose and an aldose reductase inhibitor on the sorbitol content and collagen synthesis of bovine retinal capillary pericytes in culture.
Topics: Aldehyde Reductase; Animals; Capillaries; Cattle; Cells, Cultured; Collagen; Glucose; Imidazoles; Imidazolidines; Retinal Vessels; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
High-performance liquid chromatographic analysis of glucose, fructose, sorbitol and low levels of the aldose reductase inhibitor sorbinil in human lens and plasma.
Topics: Aldehyde Reductase; Blood Glucose; Chromatography, High Pressure Liquid; Fructose; Glucose; Imidazoles; Imidazolidines; Lens, Crystalline; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
Diabetes-induced increases in vascular permeability and changes in granulation tissue levels of sorbitol, myo-inositol, chiro-inositol, and scyllo-inositol are prevented by sorbinil.
Topics: Adolescent; Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Granulation Tissue; Humans; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sorbitol; Stereoisomerism | 1986 |
Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazolidines; Inositol; Male; Neural Conduction; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol | 1984 |
Diabetic complications in lens and nerve and their prevention by sulindac or sorbinil: two novel aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Diabetic Retinopathy; Imidazoles; Imidazolidines; Indenes; Lens, Crystalline; Rabbits; Rats; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Sulindac | 1983 |
Polyol pathway activity and myo-inositol metabolism. A suggested relationship in the pathogenesis of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohols | 1983 |
Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Neural Conduction; Peripheral Nerves; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1983 |
Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Inositol; Kidney Glomerulus; Male; Proteins; Rats; Sorbitol; Sugar Alcohol Dehydrogenases | 1984 |
The effects of aldose reductase inhibition on nerve sorbitol and myoinositol concentrations in diabetic and galactosemic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Female; Galactosemias; Imidazoles; Imidazolidines; Inositol; Peripheral Nerves; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1984 |
Aldose reductase in diabetic cataracts.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus; Humans; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Lens, Crystalline; Rats; Sorbitol; Sugar Alcohol Dehydrogenases | 1981 |
The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Female; Imidazoles; Imidazolidines; Motor Neurons; Neural Conduction; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Time Factors | 1982 |
Sorbitol, inositol and nerve conduction in diabetes.
Topics: Animals; Diabetes Mellitus; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Mice; Mice, Inbred C57BL; Neural Conduction; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol | 1983 |
Has one diabetic complication been explained?
Topics: Animals; Axons; Diabetes Mellitus; Diabetic Neuropathies; Fructose; Humans; Imidazoles; Imidazolidines; Neural Conduction; Rabbits; Schwann Cells; Sorbitol | 1983 |
Regulation of growth factor mRNA levels in the eyes of diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Retinopathy; Eye; Fibroblast Growth Factor 2; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Insulin-Like Growth Factor I; Kidney; Lens, Crystalline; Lung; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sorbitol; Streptozocin | 1995 |
Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation.
Topics: Aldehyde Reductase; Amino Acid Oxidoreductases; Animals; Arginine; Benzothiazoles; Blood Pressure; Body Weight; Capillary Permeability; Citrulline; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glycation End Products, Advanced; Guanidines; Imidazoles; Imidazolidines; Inositol; Iodine Radioisotopes; Male; Methylguanidine; Naphthalenes; Nitric Oxide Synthase; omega-N-Methylarginine; Phthalazines; Rats; Rats, Sprague-Dawley; Retina; Sciatic Nerve; Serum Albumin, Bovine; Sorbitol; Thiazoles; Uvea | 1993 |
Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta.
Topics: Acetylcholine; Adenosine Diphosphate; Aldehyde Reductase; Animals; Aorta; Blood Glucose; Body Weight; Cyclic GMP; Diabetes Mellitus, Experimental; Endothelium, Vascular; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Prostaglandins; Rabbits; Sorbitol | 1993 |
Transphosphatidylation of sugar alcohols and its implications for the pathogenesis of diabetic complications.
Topics: Aldehyde Reductase; Animals; Brain; Cell Line; Cells, Cultured; Chromatography, Gas; Chromatography, Thin Layer; Diabetes Mellitus, Experimental; Humans; Imidazoles; Imidazolidines; Phosphatidic Acids; Phospholipase D; Phospholipids; Pigment Epithelium of Eye; Rats; Sorbitol; Synaptosomes | 1994 |
Polyol pathway mediates high glucose-induced collagen synthesis in proximal tubule.
Topics: Aldehyde Reductase; Animals; Cell Line; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Collagen; Gene Expression; Genes, Reporter; Glucose; Imidazoles; Imidazolidines; Kidney Tubules, Proximal; Mice; RNA, Messenger; Sorbitol; Transcriptional Activation; Transfection | 1994 |
Aldose reductase gene expression and osmotic dysregulation in cultured human retinal pigment epithelial cells.
Topics: Aldehyde Reductase; Blood Glucose; Cell Line; Fructose; Gene Expression; Glucose; Humans; Hyperglycemia; Imidazoles; Imidazolidines; Inositol; Mannitol; Osmolar Concentration; Osmosis; Pigment Epithelium of Eye; Sorbitol; Time Factors; Water-Electrolyte Balance | 1993 |
Acetyl-L-carnitine corrects electroretinographic deficits in experimental diabetes.
Topics: Acetylcarnitine; Aldehyde Reductase; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; Erythrocytes; Imidazoles; Imidazolidines; Male; Rats; Rats, Wistar; Sorbitol | 1993 |
Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Neural Conduction; Osmolar Concentration; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Taurine | 1993 |
Localization and regulation of renal Na+/myo-inositol cotransporter in diabetic rats.
Topics: 3-O-Methylglucose; Aldehyde Reductase; Animals; Base Sequence; Blood Glucose; Carrier Proteins; Diabetes Mellitus, Experimental; Heat-Shock Proteins; Hypoglycemic Agents; Imidazoles; Imidazolidines; In Situ Hybridization; Inositol; Insulin, Isophane; Kidney Cortex; Kidney Medulla; Loop of Henle; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sorbitol; Symporters; Time Factors | 1996 |
Endothelial dysfunction in diabetes mellitus.
Topics: Aldehyde Reductase; Animals; Capillary Permeability; Coloring Agents; Diabetes Mellitus, Experimental; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Evans Blue; Female; Guanidines; Imidazoles; Imidazolidines; Nitric Oxide; Rats; Rats, Sprague-Dawley; Serum Albumin; Sorbitol | 1996 |
Comparison of the effects of Zopolrestat and Sorbinil on lens myo-inositol influx.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Carbohydrate Metabolism; Carbohydrates; Culture Media; Enzyme Inhibitors; Galactose; Glucose; Imidazoles; Imidazolidines; In Vitro Techniques; Inositol; Lens, Crystalline; Male; Phthalazines; Polymers; Rats; Rats, Sprague-Dawley; Sorbitol; Thiazoles | 1997 |
Fructose-3-phosphate production and polyol pathway metabolism in diabetic rat hearts.
Topics: Administration, Oral; Ampholyte Mixtures; Animals; Chromatography, High Pressure Liquid; Cohort Studies; Deoxyglucose; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructose; Fructosephosphates; Gas Chromatography-Mass Spectrometry; Glucose; Imidazoles; Imidazolidines; Lens, Crystalline; Magnetic Resonance Spectroscopy; Male; Myocardium; Perchlorates; Phosphorus Isotopes; Polymers; Rats; Rats, Sprague-Dawley; Sorbitol | 1997 |
Depletion of phospholipid arachidonoyl-containing molecular species in a human Schwann cell line grown in elevated glucose and their restoration by an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Arachidonic Acid; Benzothiazoles; Cell Division; Culture Media; Enzyme Inhibitors; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Mannitol; Neurofibroma; Organic Chemicals; Phospholipids; Phthalazines; Piperazines; Pyrimidines; Schwann Cells; Sorbitol; Thiazoles; Tumor Cells, Cultured | 1998 |
Renal proximal tubular cell fibronectin accumulation in response to glucose is polyol pathway dependent.
Topics: Aldehyde Reductase; Animals; Basement Membrane; Diabetic Nephropathies; Enzyme Inhibitors; Fibronectins; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Kidney Tubules, Proximal; LLC-PK1 Cells; Sorbitol; Swine | 1999 |
Evaluation of an aldose reductase inhibitor on lens metabolism, ATPases and antioxidative defense in streptozotocin-diabetic rats: an intervention study.
Topics: Adenine Nucleotides; Adenosine Triphosphatases; Aldehyde Reductase; Animals; Antioxidants; Ca(2+) Mg(2+)-ATPase; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; NAD; NADP; Proton-Translocating ATPases; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Sorbitol | 2000 |
Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy.
Topics: Adrenergic alpha-Antagonists; Ammonia; Animals; Antioxidants; Cell Fractionation; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructose; Glucose; Glutamic Acid; Imidazoles; Imidazolidines; Ketoglutaric Acids; Lactic Acid; Male; Mitochondria; NAD; Oxidation-Reduction; Piperazines; Prazosin; Pyrimidines; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Retina; Sorbitol; Thioctic Acid | 2001 |
Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Glucose; Imidazoles; Imidazolidines; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Sprague-Dawley; Sorbitol | 2002 |
Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy.
Topics: Aged; Aldehyde Reductase; Animals; Apoptosis; Capillaries; Diabetic Retinopathy; Enzyme Inhibitors; Female; Glucose; Humans; Imidazoles; Imidazolidines; Male; Middle Aged; Pericytes; Polymers; Rats; Rats, Sprague-Dawley; Retinal Vessels; Sorbitol | 2004 |
Role of nitric oxide in regulating aldose reductase activation in the ischemic heart.
Topics: Aldehyde Reductase; Animals; Bradykinin; Dithiothreitol; Enzyme Activation; Enzyme Inhibitors; Ferric Compounds; Glucose; Hesperidin; Hypoglycemic Agents; Imidazolidines; Insulin; Lipid Peroxidation; Male; Metalloporphyrins; Myocardial Reperfusion Injury; Myocardium; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sorbitol; Vasodilator Agents | 2008 |