sorbitol has been researched along with pyrazines in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Fujitani, B; Komiya, M; Kuromiya, A; Matsumoto, J; Murata, M; Negoro, T; Ono, Y; Suzuki, K; Ueda, S | 1 |
| Nakamura, J | 1 |
| Giannoukakis, N | 1 |
| Bril, V; Kuromiya, A; Kurono, M; Matsumoto, T; Nakamura, K; Ono, Y | 2 |
| Fukatsu, A; Sakai, S; Samukawa, Y; Sasaki, T; Seino, Y; Ubukata, M | 1 |
| Ishibashi, Y; Kato, H; Matsui, T; Matsumoto, T; Yamagishi, S | 1 |
| Basile, G; De Jesus, DF; Kin, T; Kulkarni, RN; Kyohara, M; Okuyama, T; Shapiro, AMJ; Shirakawa, J; Tajima, K; Terauchi, Y; Togashi, Y | 1 |
2 review(s) available for sorbitol and pyrazines
| Article | Year |
|---|---|
[Role of polyol pathway in pathogenesis of diabetic microangiopathy].
Topics: Aldehyde Reductase; Animals; Diabetic Angiopathies; Fructose; Glucose; Glycation End Products, Advanced; Humans; L-Iditol 2-Dehydrogenase; Oxidative Stress; Polymers; Polymorphism, Genetic; Protein Kinase C; Pyrazines; Sorbitol; Spiro Compounds | 2005 |
Ranirestat as a therapeutic aldose reductase inhibitor for diabetic complications.
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Enzyme Inhibitors; Humans; Pyrazines; Sorbitol; Spiro Compounds; Treatment Outcome | 2008 |
1 trial(s) available for sorbitol and pyrazines
| Article | Year |
|---|---|
Absence of Drug-Drug Interactions Between Luseogliflozin, a Sodium-Glucose Co-transporter-2 Inhibitor, and Various Oral Antidiabetic Drugs in Healthy Japanese Males.
Topics: 1-Deoxynojirimycin; Adult; Antihypertensive Agents; Area Under Curve; Cross-Over Studies; Female; Humans; Hypoglycemic Agents; Japan; Male; Metformin; Middle Aged; Pioglitazone; Pyrazines; Sitagliptin Phosphate; Sorbitol; Sulfonylurea Compounds; Thiazolidinediones; Triazoles | 2015 |
5 other study(ies) available for sorbitol and pyrazines
| Article | Year |
|---|---|
Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners.
Topics: Aldehyde Reductase; Animals; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Enzyme Inhibitors; In Vitro Techniques; Lens, Crystalline; Male; Molecular Conformation; Pyrazines; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Swine | 1998 |
Ranirestat (AS-3201), a potent aldose reductase inhibitor, reduces sorbitol levels and improves motor nerve conduction velocity in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus; Diabetic Neuropathies; Enzyme Inhibitors; Male; Neural Conduction; Pyrazines; Rats; Rats, Wistar; Sorbitol; Spiro Compounds; Streptozocin | 2008 |
Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Fructose; In Vitro Techniques; Male; Neural Conduction; Pyrazines; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Spiro Compounds | 2009 |
Ranirestat has a stronger inhibitory activity on aldose reductase and suppresses inflammatory reactions in high glucose-exposed endothelial cells.
Topics: Aldehyde Reductase; Anti-Inflammatory Agents; Cell Line, Tumor; Chromatography, Liquid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Inflammation Mediators; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Rhodanine; Sorbitol; Spiro Compounds; Superoxides; Tandem Mass Spectrometry; Thiazolidines; Vascular Cell Adhesion Molecule-1 | 2016 |
Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway.
Topics: Animals; Cell Proliferation; Culture Media, Conditioned; Drug Synergism; Gene Knockout Techniques; Humans; Imidazoles; Insulin Receptor Substrate Proteins; Insulin-Secreting Cells; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Pyrazines; Receptor, IGF Type 1; Receptor, Insulin; Signal Transduction; Sorbitol | 2020 |