sorbitol has been researched along with ponalrestat in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (69.23) | 18.7374 |
| 1990's | 7 (26.92) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hisanaga, T; Kawabata, T; Kikkawa, R; Maeda, K; Shigeta, Y; Sonobe, M; Yasuda, H | 1 |
| Cameron, NE; Cotter, MA | 1 |
| Brolin, SE; Naeser, P | 1 |
| Fretten, P; Tomlinson, DR; Townsend, J | 1 |
| Larsen, JR; Sidenius, P; Tomlinson, DR | 1 |
| Tomlinson, DR; Townsend, J; Whiteley, SJ; Willars, GB | 1 |
| Archer, DR; Dahlin, LB; McLean, WG | 1 |
| Churchill, RD; Compton, AM; Tomlinson, DR; Townsend, J; Willars, GB | 1 |
| Cameron, NE; Cotter, MA; Robertson, S | 2 |
| Saperstein, R; Slater, EE; Vicario, PP | 1 |
| Brolin, SE; Eriksson, UJ; Naeser, P | 2 |
| Airey, CM; Kemp, JV; Perkins, CM; Price, DE; Wales, JK | 1 |
| Kunjara, S; McLean, P; Sochor, M | 1 |
| Calcutt, NA; Tomlinson, DR; Willars, GB | 1 |
| Airey, CM; Alani, SM; Price, DE; Wales, JK | 1 |
| De Leeuw, IH; Rillaerts, EG; Vertommen, JJ | 1 |
| Earl, DC; Harrison, HE; Mirrlees, DJ; Stribling, D | 1 |
| Kador, PF; Kinoshita, JH; Sharpless, NE | 1 |
| Mayer, JH; McLean, WG; Tomlinson, DR | 1 |
| Cooper, ME; Dunlop, M; Jerums, G; Soulis-Liparota, T | 1 |
| Faiman, G; Ganguly, P; Mehta, A; Thliveris, JA | 1 |
| Calcutt, NA; Kalichman, MW; Mizisin, AP; Myers, RR; Powell, HC | 1 |
| Gillies, MC; Naidoo, D; Salonikas, C; Simpson, JM; Stayt, J; Su, T | 1 |
| Blessing, K; Fujisawa, S; Kador, PF; Lee, JW; Lou, MF | 1 |
1 review(s) available for sorbitol and ponalrestat
| Article | Year |
|---|---|
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; Corneal Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Fluorenes; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Models, Molecular; Naphthalenes; Phthalazines; Rhodanine; Sorbitol; Structure-Activity Relationship; Substrate Specificity; Sugar Alcohol Dehydrogenases; Thiazolidines; Tissue Distribution | 1985 |
1 trial(s) available for sorbitol and ponalrestat
| Article | Year |
|---|---|
The effect of aldose reductase inhibition on erythrocyte polyols and galactitol accumulation in diabetic patients.
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Double-Blind Method; Erythrocytes; Galactitol; Humans; Hypoglycemic Agents; Inositol; Phthalazines; Pyridazines; Sorbitol; Sugar Alcohol Dehydrogenases; Sugar Alcohols | 1989 |
24 other study(ies) available for sorbitol and ponalrestat
| Article | Year |
|---|---|
A combination of the aldose reductase inhibitor, statil, and the prostaglandin E1 analogue, OP1206.alpha CD, completely improves sciatic motor nerve conduction velocity in streptozocin-induced chronically diabetic rats.
Topics: Aldehyde Reductase; Alprostadil; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hypoglycemic Agents; Inositol; Male; Neural Conduction; Phthalazines; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1992 |
Dissociation between biochemical and functional effects of the aldose reductase inhibitor, ponalrestat, on peripheral nerve in diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetic Neuropathies; Fructose; Hypoglycemic Agents; Hypoxia; Male; Neural Conduction; Peripheral Nerves; Phthalazines; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol | 1992 |
Influence of glucose, fructose and aldose reductase inhibition on retinal sorbitol metabolism.
Topics: Aldehyde Reductase; Animals; Cattle; Fructose; Glucose; L-Iditol 2-Dehydrogenase; Phthalazines; Retina; Sorbitol | 1991 |
Prevention of defective axonal transport in streptozocin-diabetic rats by treatment with "Statil" (ICI 128436), an aldose reductase inhibitor.
Topics: Animals; Autonomic Fibers, Preganglionic; Axonal Transport; Blood Glucose; Choline O-Acetyltransferase; Cholinergic Fibers; Diabetes Mellitus, Experimental; Male; Phthalazines; Polymers; Pyridazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Vagus Nerve | 1985 |
Slow component-a of axonal transport, nerve myo-inositol, and aldose reductase inhibition in streptozocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Diabetes Mellitus, Experimental; Fructose; Ganglia, Spinal; Glucose; Inositol; Male; Neurons; Phthalazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1986 |
Fast anterograde axonal transport in wasted and non-wasted diabetic rats; effects of aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Blood Glucose; Body Temperature; Diabetes Mellitus, Experimental; Fructose; Inositol; Insulin; Male; Motor Neurons; Muscles; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1986 |
Treatment with an aldose reductase inhibitor can reduce the susceptibility of fast axonal transport following nerve compression in the streptozotocin-diabetic rat.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Female; Inositol; Nerve Compression Syndromes; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1987 |
Studies on peripheral nerve and lens in long-term experimental diabetes: effects of the aldose reductase inhibitor statil.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Body Weight; Carbohydrates; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Ileum; Inositol; Lens, Crystalline; Male; Muscles; Neural Conduction; Peripheral Nerves; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases | 1988 |
Contractile properties of cardiac papillary muscle in streptozotocin-diabetic rats and the effects of aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Electric Stimulation; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Reference Values; Sorbitol; Sugar Alcohol Dehydrogenases; Temperature; Ventricular Function | 1989 |
The effect of ponalrestat on sorbitol levels in the lens of obese and diabetic mice.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Insulin; Lens, Crystalline; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Phthalazines; Sorbitol; Sugar Alcohol Dehydrogenases | 1989 |
The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Kinetics; Male; Muscles; Neural Conduction; Peroneal Nerve; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1989 |
Influence of sorbitol accumulation on growth and development of embryos cultured in elevated levels of glucose and fructose.
Topics: Abnormalities, Drug-Induced; Aldehyde Reductase; Animals; Embryo, Mammalian; Female; Fructose; Glucose; Organ Culture Techniques; Phthalazines; Pregnancy; Rats; Rats, Inbred Strains; Sorbitol | 1989 |
The effect of aldose reductase inhibitor Statil (ICI 128436) on the glucose over-utilization in kidney of diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Glucose; Glucuronates; Kidney; Lactates; Organ Size; Pentosephosphates; Phthalazines; Pyridazines; Rats; Sorbitol; Xylulose | 1988 |
Statil-sensitive polyol formation in nerve of galactose-fed mice.
Topics: Aldehyde Reductase; Animals; Carbohydrates; Diabetes Mellitus, Experimental; Galactitol; Galactose; Inositol; Mice; Mice, Inbred C57BL; Peripheral Nerves; Phthalazines; Pyridazines; Sorbitol; Sugar Alcohol Dehydrogenases; Sugar Alcohols | 1988 |
Effect of aldose reductase inhibition on nerve conduction velocity and resistance to ischemic conduction block in experimental diabetes.
Topics: Action Potentials; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Inositol; Insulin; Ischemia; Kinetics; Male; Neural Conduction; Phthalazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Tail | 1988 |
Sorbitol metabolism in the retina, optic nerve, and sural nerve of diabetic rats treated with an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Female; L-Iditol 2-Dehydrogenase; Optic Nerve; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Retina; Sorbitol; Spinal Nerves; Sugar Alcohol Dehydrogenases; Sural Nerve | 1988 |
Effect of statil (ICI 128436) on erythrocyte viscosity in vitro.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocyte Deformability; Erythrocytes; Female; Humans; Male; Phthalazines; Pyridazines; Sorbitol | 1988 |
Properties of ICI 128,436, a novel aldose reductase inhibitor, and its effects on diabetic complications in the rat.
Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Diabetes Mellitus, Experimental; Dogs; Erythrocytes; Fructose; Galactitol; Humans; In Vitro Techniques; Kidney Cortex; Lens, Crystalline; Male; Motor Neurons; Neural Conduction; Phthalazines; Pyridazines; Rats; Retina; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
Slow orthograde axonal transport of radiolabelled protein in sciatic motoneurones of rats with short-term experimental diabetes: effects of treatment with an aldose reductase inhibitor or myo-inositol.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Inositol; Male; Motor Neurons; Phthalazines; Proline; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1984 |
The relative roles of advanced glycation, oxidation and aldose reductase inhibition in the development of experimental diabetic nephropathy in the Sprague-Dawley rat.
Topics: Albuminuria; Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Body Weight; Butylated Hydroxytoluene; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycated Hemoglobin; Glycosylation; Guanidines; Kidney Cortex; Male; Malondialdehyde; Oxidation-Reduction; Phthalazines; Probucol; Rats; Rats, Sprague-Dawley; Sorbitol | 1995 |
Effect of statil on kidney structure, function and polyol accumulation in diabetes mellitus.
Topics: Aldehyde Reductase; Animals; Diabetic Nephropathies; Kidney; Male; Phthalazines; Rats; Rats, Sprague-Dawley; Sorbitol | 1993 |
Decreased endoneurial fluid electrolytes in normal rat sciatic nerve after aldose reductase inhibition.
Topics: Adenosine Triphosphatases; Aldehyde Reductase; Animals; Body Water; Chlorides; Connective Tissue; Female; Fructose; Glucose; Homeostasis; Inositol; Phthalazines; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sodium; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1993 |
Effect of high glucose on permeability of retinal capillary endothelium in vitro.
Topics: Animals; Blood-Retinal Barrier; Capillary Permeability; Carbon Radioisotopes; Cattle; Cells, Cultured; Diffusion Chambers, Culture; Electric Impedance; Endothelium, Vascular; Enzyme Inhibitors; Fructose; Glucose; Guanidines; Inulin; Lactic Acid; Phthalazines; Polymers; Pyruvic Acid; Retinal Vessels; Sorbitol | 1997 |
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats.
Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fluorenes; Glutathione; Glycation End Products, Advanced; Glycosylation; Hydantoins; Lens, Crystalline; Naphthalenes; Phthalazines; Rats; Rats, Sprague-Dawley; Sorbitol; Spectrometry, Fluorescence | 2000 |