sorbitol and ponalrestat

sorbitol has been researched along with ponalrestat in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199018 (69.23)18.7374
1990's7 (26.92)18.2507
2000's1 (3.85)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hisanaga, T; Kawabata, T; Kikkawa, R; Maeda, K; Shigeta, Y; Sonobe, M; Yasuda, H1
Cameron, NE; Cotter, MA1
Brolin, SE; Naeser, P1
Fretten, P; Tomlinson, DR; Townsend, J1
Larsen, JR; Sidenius, P; Tomlinson, DR1
Tomlinson, DR; Townsend, J; Whiteley, SJ; Willars, GB1
Archer, DR; Dahlin, LB; McLean, WG1
Churchill, RD; Compton, AM; Tomlinson, DR; Townsend, J; Willars, GB1
Cameron, NE; Cotter, MA; Robertson, S2
Saperstein, R; Slater, EE; Vicario, PP1
Brolin, SE; Eriksson, UJ; Naeser, P2
Airey, CM; Kemp, JV; Perkins, CM; Price, DE; Wales, JK1
Kunjara, S; McLean, P; Sochor, M1
Calcutt, NA; Tomlinson, DR; Willars, GB1
Airey, CM; Alani, SM; Price, DE; Wales, JK1
De Leeuw, IH; Rillaerts, EG; Vertommen, JJ1
Earl, DC; Harrison, HE; Mirrlees, DJ; Stribling, D1
Kador, PF; Kinoshita, JH; Sharpless, NE1
Mayer, JH; McLean, WG; Tomlinson, DR1
Cooper, ME; Dunlop, M; Jerums, G; Soulis-Liparota, T1
Faiman, G; Ganguly, P; Mehta, A; Thliveris, JA1
Calcutt, NA; Kalichman, MW; Mizisin, AP; Myers, RR; Powell, HC1
Gillies, MC; Naidoo, D; Salonikas, C; Simpson, JM; Stayt, J; Su, T1
Blessing, K; Fujisawa, S; Kador, PF; Lee, JW; Lou, MF1

Reviews

1 review(s) available for sorbitol and ponalrestat

ArticleYear
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:7

    Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; Corneal Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Fluorenes; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Models, Molecular; Naphthalenes; Phthalazines; Rhodanine; Sorbitol; Structure-Activity Relationship; Substrate Specificity; Sugar Alcohol Dehydrogenases; Thiazolidines; Tissue Distribution

1985

Trials

1 trial(s) available for sorbitol and ponalrestat

ArticleYear
The effect of aldose reductase inhibition on erythrocyte polyols and galactitol accumulation in diabetic patients.
    Diabetic medicine : a journal of the British Diabetic Association, 1989, Volume: 6, Issue:9

    Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Double-Blind Method; Erythrocytes; Galactitol; Humans; Hypoglycemic Agents; Inositol; Phthalazines; Pyridazines; Sorbitol; Sugar Alcohol Dehydrogenases; Sugar Alcohols

1989

Other Studies

24 other study(ies) available for sorbitol and ponalrestat

ArticleYear
A combination of the aldose reductase inhibitor, statil, and the prostaglandin E1 analogue, OP1206.alpha CD, completely improves sciatic motor nerve conduction velocity in streptozocin-induced chronically diabetic rats.
    Metabolism: clinical and experimental, 1992, Volume: 41, Issue:7

    Topics: Aldehyde Reductase; Alprostadil; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hypoglycemic Agents; Inositol; Male; Neural Conduction; Phthalazines; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol

1992
Dissociation between biochemical and functional effects of the aldose reductase inhibitor, ponalrestat, on peripheral nerve in diabetic rats.
    British journal of pharmacology, 1992, Volume: 107, Issue:4

    Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetic Neuropathies; Fructose; Hypoglycemic Agents; Hypoxia; Male; Neural Conduction; Peripheral Nerves; Phthalazines; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol

1992
Influence of glucose, fructose and aldose reductase inhibition on retinal sorbitol metabolism.
    Acta ophthalmologica, 1991, Volume: 69, Issue:5

    Topics: Aldehyde Reductase; Animals; Cattle; Fructose; Glucose; L-Iditol 2-Dehydrogenase; Phthalazines; Retina; Sorbitol

1991
Prevention of defective axonal transport in streptozocin-diabetic rats by treatment with "Statil" (ICI 128436), an aldose reductase inhibitor.
    Diabetes, 1985, Volume: 34, Issue:10

    Topics: Animals; Autonomic Fibers, Preganglionic; Axonal Transport; Blood Glucose; Choline O-Acetyltransferase; Cholinergic Fibers; Diabetes Mellitus, Experimental; Male; Phthalazines; Polymers; Pyridazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Vagus Nerve

1985
Slow component-a of axonal transport, nerve myo-inositol, and aldose reductase inhibition in streptozocin-diabetic rats.
    Diabetes, 1986, Volume: 35, Issue:4

    Topics: Aldehyde Reductase; Animals; Axonal Transport; Diabetes Mellitus, Experimental; Fructose; Ganglia, Spinal; Glucose; Inositol; Male; Neurons; Phthalazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases

1986
Fast anterograde axonal transport in wasted and non-wasted diabetic rats; effects of aldose reductase inhibition.
    Diabetes research (Edinburgh, Scotland), 1986, Volume: 3, Issue:9

    Topics: Aldehyde Reductase; Animals; Axonal Transport; Blood Glucose; Body Temperature; Diabetes Mellitus, Experimental; Fructose; Inositol; Insulin; Male; Motor Neurons; Muscles; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases

1986
Treatment with an aldose reductase inhibitor can reduce the susceptibility of fast axonal transport following nerve compression in the streptozotocin-diabetic rat.
    Diabetologia, 1987, Volume: 30, Issue:6

    Topics: Aldehyde Reductase; Animals; Axonal Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Female; Inositol; Nerve Compression Syndromes; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases

1987
Studies on peripheral nerve and lens in long-term experimental diabetes: effects of the aldose reductase inhibitor statil.
    Metabolism: clinical and experimental, 1988, Volume: 37, Issue:5

    Topics: Aldehyde Reductase; Animals; Axonal Transport; Body Weight; Carbohydrates; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Ileum; Inositol; Lens, Crystalline; Male; Muscles; Neural Conduction; Peripheral Nerves; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases

1988
Contractile properties of cardiac papillary muscle in streptozotocin-diabetic rats and the effects of aldose reductase inhibition.
    Diabetologia, 1989, Volume: 32, Issue:6

    Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Electric Stimulation; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Reference Values; Sorbitol; Sugar Alcohol Dehydrogenases; Temperature; Ventricular Function

1989
The effect of ponalrestat on sorbitol levels in the lens of obese and diabetic mice.
    Biochemistry international, 1989, Volume: 19, Issue:3

    Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Insulin; Lens, Crystalline; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Phthalazines; Sorbitol; Sugar Alcohol Dehydrogenases

1989
The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats.
    Quarterly journal of experimental physiology (Cambridge, England), 1989, Volume: 74, Issue:6

    Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Kinetics; Male; Muscles; Neural Conduction; Peroneal Nerve; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases

1989
Influence of sorbitol accumulation on growth and development of embryos cultured in elevated levels of glucose and fructose.
    Diabetes research (Edinburgh, Scotland), 1989, Volume: 11, Issue:1

    Topics: Abnormalities, Drug-Induced; Aldehyde Reductase; Animals; Embryo, Mammalian; Female; Fructose; Glucose; Organ Culture Techniques; Phthalazines; Pregnancy; Rats; Rats, Inbred Strains; Sorbitol

1989
The effect of aldose reductase inhibitor Statil (ICI 128436) on the glucose over-utilization in kidney of diabetic rats.
    Biochemical pharmacology, 1988, Sep-01, Volume: 37, Issue:17

    Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Glucose; Glucuronates; Kidney; Lactates; Organ Size; Pentosephosphates; Phthalazines; Pyridazines; Rats; Sorbitol; Xylulose

1988
Statil-sensitive polyol formation in nerve of galactose-fed mice.
    Metabolism: clinical and experimental, 1988, Volume: 37, Issue:5

    Topics: Aldehyde Reductase; Animals; Carbohydrates; Diabetes Mellitus, Experimental; Galactitol; Galactose; Inositol; Mice; Mice, Inbred C57BL; Peripheral Nerves; Phthalazines; Pyridazines; Sorbitol; Sugar Alcohol Dehydrogenases; Sugar Alcohols

1988
Effect of aldose reductase inhibition on nerve conduction velocity and resistance to ischemic conduction block in experimental diabetes.
    Diabetes, 1988, Volume: 37, Issue:7

    Topics: Action Potentials; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Inositol; Insulin; Ischemia; Kinetics; Male; Neural Conduction; Phthalazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Tail

1988
Sorbitol metabolism in the retina, optic nerve, and sural nerve of diabetic rats treated with an aldose reductase inhibitor.
    Metabolism: clinical and experimental, 1988, Volume: 37, Issue:12

    Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Female; L-Iditol 2-Dehydrogenase; Optic Nerve; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Retina; Sorbitol; Spinal Nerves; Sugar Alcohol Dehydrogenases; Sural Nerve

1988
Effect of statil (ICI 128436) on erythrocyte viscosity in vitro.
    Diabetes, 1988, Volume: 37, Issue:4

    Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocyte Deformability; Erythrocytes; Female; Humans; Male; Phthalazines; Pyridazines; Sorbitol

1988
Properties of ICI 128,436, a novel aldose reductase inhibitor, and its effects on diabetic complications in the rat.
    Metabolism: clinical and experimental, 1985, Volume: 34, Issue:4

    Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Diabetes Mellitus, Experimental; Dogs; Erythrocytes; Fructose; Galactitol; Humans; In Vitro Techniques; Kidney Cortex; Lens, Crystalline; Male; Motor Neurons; Neural Conduction; Phthalazines; Pyridazines; Rats; Retina; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases

1985
Slow orthograde axonal transport of radiolabelled protein in sciatic motoneurones of rats with short-term experimental diabetes: effects of treatment with an aldose reductase inhibitor or myo-inositol.
    Journal of neurochemistry, 1984, Volume: 43, Issue:5

    Topics: Aldehyde Reductase; Animals; Axonal Transport; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Inositol; Male; Motor Neurons; Phthalazines; Proline; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases

1984
The relative roles of advanced glycation, oxidation and aldose reductase inhibition in the development of experimental diabetic nephropathy in the Sprague-Dawley rat.
    Diabetologia, 1995, Volume: 38, Issue:4

    Topics: Albuminuria; Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Body Weight; Butylated Hydroxytoluene; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycated Hemoglobin; Glycosylation; Guanidines; Kidney Cortex; Male; Malondialdehyde; Oxidation-Reduction; Phthalazines; Probucol; Rats; Rats, Sprague-Dawley; Sorbitol

1995
Effect of statil on kidney structure, function and polyol accumulation in diabetes mellitus.
    Molecular and cellular biochemistry, 1993, Aug-11, Volume: 125, Issue:1

    Topics: Aldehyde Reductase; Animals; Diabetic Nephropathies; Kidney; Male; Phthalazines; Rats; Rats, Sprague-Dawley; Sorbitol

1993
Decreased endoneurial fluid electrolytes in normal rat sciatic nerve after aldose reductase inhibition.
    Journal of the neurological sciences, 1993, Volume: 116, Issue:1

    Topics: Adenosine Triphosphatases; Aldehyde Reductase; Animals; Body Water; Chlorides; Connective Tissue; Female; Fructose; Glucose; Homeostasis; Inositol; Phthalazines; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sodium; Sodium-Potassium-Exchanging ATPase; Sorbitol

1993
Effect of high glucose on permeability of retinal capillary endothelium in vitro.
    Investigative ophthalmology & visual science, 1997, Volume: 38, Issue:3

    Topics: Animals; Blood-Retinal Barrier; Capillary Permeability; Carbon Radioisotopes; Cattle; Cells, Cultured; Diffusion Chambers, Culture; Electric Impedance; Endothelium, Vascular; Enzyme Inhibitors; Fructose; Glucose; Guanidines; Inulin; Lactic Acid; Phthalazines; Polymers; Pyruvic Acid; Retinal Vessels; Sorbitol

1997
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:2

    Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fluorenes; Glutathione; Glycation End Products, Advanced; Glycosylation; Hydantoins; Lens, Crystalline; Naphthalenes; Phthalazines; Rats; Rats, Sprague-Dawley; Sorbitol; Spectrometry, Fluorescence

2000