sorbitol and imidazolidines

sorbitol has been researched along with imidazolidines in 110 studies

Research

Studies (110)

Timeframe	Studies, this research(%)	All Research%
pre-1990	59 (53.64)	18.7374
1990's	35 (31.82)	18.2507
2000's	12 (10.91)	29.6817
2010's	4 (3.64)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fukushi, S; Kador, P; Kinoshita, JH; Merola, LO	1
Aldinger, CE; MacDonald, DP; Peterson, MJ; Sarges, R	1
Kato, N; Kurono, M; Matsubara, A; Mizuno, K; Nakano, K	1
Edmands, S; Yancey, PH	1
Cammarata, PR; Chen, HQ; Yang, J; Yorio, T	2
Aperia, A; Celsi, G; Eklöf, AC; Körner, A; Linné, T; Persson, B	1
Aldinger, CE; Beyer, TA; Bordner, J; Burdi, DF; Bussolotti, DL; Inskeep, PB; Lipinski, CA; Siegel, TW	1
Greene, DA; Nathaniel, V; Sima, AA	1
Lowitt, S; Malone, JI	1
Flam, BR; Sawicki, DR; Sredy, J	1
Wasada, T	1
Futterweit, S; Hammer, E; Oates, P; Siegel, TW; Trachtman, H	1
Kato, K; Miwa, I; Mizota, M; Nakayama, K; Okuda, J	1
Brennan, MC; Del Monte, MA; Diaz, TC; Greene, DA; Lattimer, SA; Nakamura, J; Rabbani, R	1
Tagashira, E; Yoneta, T	1
Cook, WR; Lowitt, S; Malone, JI	1
Hamprecht, B; Thiess, U; Wiesinger, H	1
Brenner, RM; Gullans, SR; Heilig, CW; Kone, BC; Yu, AS	1
Greene, DA	1
Robinson, JP; Tomlinson, DR; Willars, GB	1
Barr, CC	1
Calthrop-Owen, EF; Tomlinson, DR; Willars, GB	1
Dunlap, JA; Yorek, MA	1
Plurad, SB; Schmidt, RE; Sherman, WR; Tilton, RG; Williamson, JR	1
Craven, PA; DeRubertis, FR	1
Chang, K; Eades, DM; Kilo, C; Province, MA; Pugliese, G; Sherman, WR; Tilton, RG; Williamson, JR	1
Azar, S; Brown, DM; Mauer, SM; Steffes, MW	1
Bitensky, MW; Buican, T; Dembo, M; Keaton, PA; Kowluru, A; Kowluru, R	1
Li, WY	1
Ashton, MA; Beyer, TA; Goddu, KJ; Hutson, NJ; Rafford, CE; Yeh, LA	1
Fujimori, S; Hirata, Y; Okada, K	1
Gonzalez, AM; Hothersall, JS; McLean, P; Sochor, M	1
Mayer, JH; Tomlinson, DR	1
Greene, DA; Lattimer, SA	1
MacGregor, LC; Matschinsky, FM	2
Cohen, M	1
Cheng, HM; González, RG	1
Peterson, MJ; Sarges, R	1
Akagi, Y; Kador, PF; Kinoshita, JH	1
Beyer, TA; Hutson, NJ; Rafford, CE; Yeh, LA	1
Collier, J; Gundersen, K; Mehta, DJ; Peterson, MJ; Pitts, NE; Shaw, GL; Vreeland, F	1
Odom, JD; Williams, WF	1
Baar, S; Bareford, D; Barnett, AH; Jennings, PE; Stone, PC; Stuart, J	1
Boss, GR; Lane, MJ; Lorenzi, M; Montisano, DF; Toledo, S	1
Clarke, BF; Ewing, DJ; Martyn, CN; Reid, W; Young, RJ	1
Dyck, PJ; Karnes, JL; Minnerath, SR; Poduslo, JF; Vilen, TH; Yao, JK; Zimmerman, BR	1
Bril, V; Brown, MB; Greene, DA; Lattimer, SA; McEwen, TA; Nathaniel, V; Sima, AA	1
Ross, IS; Whiting, PH	1
Lerman, S; Moran, M	1
Dunlap, JA; Ginsberg, BH; Yorek, MA	1
Halonen, T; Hyvönen, SK; Kilpeläinen, H; Lehtinen, JM; Puhakainen, E; Uusitupa, M	1
Cohen, MP; Dasmahapatra, A; Robey, C; Suarez, S	1
Beyer-Mears, A; Cruz, E	1
Burgess, SE; Cheng, H; Crabbe, MJ; Petchey, M	1
Kador, PF; Kinoshita, JH; Sharpless, NE	1
Das, B; Hair, GA; Srivastava, SK	1
Khatami, M; Li, W; Rockey, JH	1
Crabbe, MJ; Lloyd, P	1
Ackermann, KE; Chang, K; Kilo, C; Marvel, J; Rowold, E; Sherman, WR; Tomlinson, M; Williamson, JR	1
Mayer, JH; Moriarty, RJ; Tomlinson, DR	1
Cobo, LM; Cogan, DG; Datilis, MB; Kador, PF; Kinoshita, JH; Kupfer, C; Robison, G	1
Clarke, BF; Ewing, DJ; Martyn, CN; Young, RJ	1
Cotlier, E; Hollander, JD; Jacobson, M; Sharma, YR	1
Bernstein, M; Finegold, D; Greene, DA; Lattimer, SA; Nolle, S	1
Gillon, KR; Hawthorne, JN; Tomlinson, DR	1
Beyer-Mears, A; Cohen, MP; Ku, L	1
Handelsman, DJ; Hanwell, MA; Satchell, PM; Turtle, JR; Yue, DK	1
Lomecky-Janousek, MZ; Popp-Snijders, C; Schouten, JA; van der Veen, EA	1
Aldinger, CE; Leavengood, H; Malone, JI; O'Brien, MM; Page, MG; Peterson, MJ	1
Catiles, M; Kador, P; Kinoshita, JH	1
Hayano, S; Nozawa, Y; Ono, H	1
Hanwell, MA; Satchell, PM; Turtle, JR; Yue, DK	1
Gillon, KR; Hawthorne, JN	1
Martin, DB; Simmons, DA; Winegrad, AI	1
Albrecht, BN; Florkiewicz, RZ; Lowe, WL; Spanheimer, RG; Yorek, MA	1
Hotta, N; Kawamura, T; Matsumae, H; Sakamoto, N; Sano, T; Suzuki, K	1
Chang, K; Corbett, JA; Currie, MG; Hasan, KS; McDaniel, ML; Misko, TP; Moore, WM; Petrash, JM; Smith, SR; Tilton, RG	1
Cohen, RA; Palacino, JJ; Tesfamariam, B; Weisbrod, RM	1
Greene, DA; Lattimer, SA; Nakamura, J	1
Bleyer, AJ; Fumo, P; Goldfarb, S; Simmons, DA; Snipes, ER; Ziyadeh, FN	1
Greene, DA; Henry, DN; Killen, PD; Stevens, MJ; Thomas, TP	1
Kozak, WM; Lowitt, S; Malone, JI; Orfalian, Z; Salem, A	1
Greene, DA; Kamijo, M; Lattimer, SA; Sima, AA; Stevens, MJ; Van Huysen, C	1
Hamada, Y; Hara, T; Hotta, N; Koh, N; Mori, K; Nakamura, J; Nakashima, E; Naruse, K; Sakakibara, F; Wakao, T	1
Lowe, WL; Matsushita, K; Stokes, JB; Wiese, TJ; Yorek, MA	1
Hamada, Y; Hotta, N; Kakuta, H; Koh, N; Matsubara, A; Mizuno, K; Nakamura, J; Naruse, K; Sakakibara, F; Sasaki, H	1
Chakir, M; Plante, GE	1
Beyer-Mears, A; Cruz, E; Diecke, FP; Mistry, K	1
Brown, TR; Kappler, F; Lal, S; Randall, WC; Szwergold, BS; Taylor, AH; Walker, M	1
Eichberg, J; Kuruvilla, R	1
Morrisey, K; Phillips, AO; Steadman, R; Williams, JD	1
Hotta, N; Kawamura, T; Sakakibara, F; Sakamoto, N; Sano, T; Sasaki, H; Suzuki, K	1
Kato, N; Makino, M; Mizuno, K; Suzuki, T; Yagihashi, S	1
Fathallah, L; Obrosova, IG	1
Lang, HJ; Obrosova, IG; Stevens, MJ	1
Aoki, T; Makino, M; Mizuno, K; Sassa, H; Sobajima, H; Suzuki, T; Taniko, K	1
Bhatnagar, A; Chandra, D; Jackson, EB; Kelley, R; Ramana, KV; Srivastava, SK	1
Amano, S; Hirooka, H; Inagaki, Y; Jomori, T; Kato, N; Makino, M; Okamoto, T; Takeuchi, M; Taniko, K; Yamagishi, Si	1
Abatan, OI; Frank, RN; Kumagai, AK; Minchenko, AG; Obrosova, IG; Stevens, MJ; Vasupuram, R; White, L	1
Akiyama, N; Hamada, Y; Hirooka, H; Horiuchi, S; Hotta, N; Kamiya, H; Li, W; Nakamura, J; Nakashima, E; Naruse, K; Oiso, Y; Takahashi, N	1
Asnaghi, V; Dagher, Z; Gerhardinger, C; Hoehn, T; Lorenzi, M; Park, YS	1
Hirooka, H; Obrosova, IG; Pacher, P; Stevens, MJ; Szabó, C; Yorek, MA; Zsengeller, Z	1
Miyasita, Y; Oyama, T; Shirai, K; Watanabe, H	1
Bhatnagar, A; Kaiserova, K; Srivastava, S; Tang, XL	1
Hattori, T; Matsubara, A; Ogura, Y; Taniguchi, K	1
Agardh, CD; Agardh, E; El-Remessy, AB; Maksimchyk, Y; Obrosova, IG; Pacher, P; Smith, ML	1
Hirooka, H; Nadler, JL; Obrosova, IG; Shevalye, H; Stavniichuk, R	1
Huang, Q; Liu, Q; Ouyang, D	1

Reviews

5 review(s) available for sorbitol and imidazolidines

Article	Year
Aldose reductase in diabetic complications of the eye. Metabolism: clinical and experimental, 1979, Volume: 28, Issue:4 Suppl 1 Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Chromans; Cornea; Diabetes Complications; Diabetic Retinopathy; Epithelium; Eye Diseases; Female; Galactitol; Galactose; Humans; Imidazoles; Imidazolidines; Lens, Crystalline; Mice; Mice, Obese; NADP; Polymers; Pregnancy; Rats; Regeneration; Retina; Rodentia; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Xylitol	1979
Diabetic retinopathy. The Journal of the Kentucky Medical Association, 1986, Volume: 84, Issue:4 Topics: Adult; Aldehyde Reductase; Aneurysm; Capillaries; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Edema; Humans; Imidazoles; Imidazolidines; Laser Therapy; Neovascularization, Pathologic; Retinal Diseases; Retinal Vessels; Sorbitol; Vitrectomy	1986
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications. Journal of medicinal chemistry, 1985, Volume: 28, Issue:7 Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; Corneal Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Fluorenes; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Models, Molecular; Naphthalenes; Phthalazines; Rhodanine; Sorbitol; Structure-Activity Relationship; Substrate Specificity; Sugar Alcohol Dehydrogenases; Thiazolidines; Tissue Distribution	1985
NIH conference. Aldose reductase and complications of diabetes. Annals of internal medicine, 1984, Volume: 101, Issue:1 Topics: Aldehyde Reductase; Animals; Axonal Transport; Cataract; Corneal Diseases; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Galactosemias; Humans; Imidazoles; Imidazolidines; Lens, Crystalline; Osmolar Concentration; Peripheral Nerves; Rats; Sorbitol; Structure-Activity Relationship; Sugar Alcohol Dehydrogenases	1984
Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications. Medicinal chemistry (Shariqah (United Arab Emirates)), 2019, Volume: 15, Issue:1 Topics: Aldehyde Reductase; Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructose; Humans; Hypoglycemic Agents; Imidazolidines; Oxidative Stress; Sorbitol	2019

Trials

10 trial(s) available for sorbitol and imidazolidines

Article	Year
Peripheral nerve repair following ARI treatment. Advances in experimental medicine and biology, 1991, Volume: 291 Topics: Aldehyde Reductase; Axons; Diabetic Neuropathies; Double-Blind Method; Humans; Imidazoles; Imidazolidines; Nerve Regeneration; Neurons; Peripheral Nervous System Diseases; Ranvier's Nodes; Sorbitol	1991
Clinical experience with sorbinil--an aldose reductase inhibitor. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Aldehyde Reductase; Animals; Autonomic Nervous System Diseases; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Diabetic Neuropathies; Diabetic Retinopathy; Double-Blind Method; Humans; Imidazoles; Imidazolidines; Pain; Rats; Sorbitol; Sugar Alcohol Dehydrogenases	1986
Six-month treatment with sorbinil in asymptomatic diabetic neuropathy. Failure to improve abnormal nerve function. Diabetes, 1987, Volume: 36, Issue:9 Topics: Adult; Aldehyde Reductase; Autonomic Nervous System; Clinical Trials as Topic; Diabetic Neuropathies; Double-Blind Method; Female; Heart Rate; Humans; Imidazoles; Imidazolidines; Male; Middle Aged; Motor Neurons; Neurons, Afferent; Peripheral Nerves; Random Allocation; Sorbitol; Sugar Alcohol Dehydrogenases	1987
Regeneration and repair of myelinated fibers in sural-nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil. The New England journal of medicine, 1988, Sep-01, Volume: 319, Issue:9 Topics: Action Potentials; Aldehyde Reductase; Biopsy; Clinical Trials as Topic; Demyelinating Diseases; Diabetic Neuropathies; Double-Blind Method; Humans; Imidazoles; Imidazolidines; Nerve Fibers; Nerve Regeneration; Neural Conduction; Random Allocation; Sorbitol; Sugar Alcohol Dehydrogenases; Sural Nerve	1988
The effect of sorbinil treatment on red cell sorbitol levels and clinical and electrophysiological parameters of diabetic neuropathy. Journal of neurology, 1986, Volume: 233, Issue:3 Topics: Adult; Clinical Trials as Topic; Diabetic Neuropathies; Double-Blind Method; Erythrocytes; Female; Humans; Imidazoles; Imidazolidines; Male; Middle Aged; Neural Conduction; Peripheral Nerves; Random Allocation; Sorbitol	1986
The penetration of Sorbinil, an aldose reductase inhibitor, into lens, aqueous humour and erythrocytes of patients undergoing cataract extraction. Experimental eye research, 1985, Volume: 40, Issue:1 Topics: Aged; Aldehyde Reductase; Aqueous Humor; Cataract Extraction; Chromatography, High Pressure Liquid; Diabetes Mellitus; Erythrocytes; Female; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; Middle Aged; Sorbitol; Sugar Alcohol Dehydrogenases	1985
Aldose reductase inhibition in diabetes. Diabetic medicine : a journal of the British Diabetic Association, 1984, Volume: 1, Issue:2 Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Erythrocytes, Abnormal; Humans; Imidazoles; Imidazolidines; Rats; Sorbitol; Sugar Alcohol Dehydrogenases	1984
myo-Inositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment. Diabetologia, 1984, Volume: 27, Issue:5 Topics: Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Double-Blind Method; Erythrocytes; Female; Gas Chromatography-Mass Spectrometry; Humans; Imidazoles; Imidazolidines; Inositol; Male; Middle Aged; Sorbitol; Sugar Alcohol Dehydrogenases	1984
Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects. Diabetes, 1984, Volume: 33, Issue:1 Topics: Administration, Oral; Adolescent; Adult; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Erythrocytes; Hemoglobin A; Humans; Imidazoles; Imidazolidines; Male; Polymers; Rats; Rats, Inbred Strains; Sorbitol	1984
Effect of aldose reductase inhibitors on glucose-induced changes in sorbitol and myo-inositol metabolism in human neutrophils. Diabetic medicine : a journal of the British Diabetic Association, 1999, Volume: 16, Issue:1 Topics: Adult; Aldehyde Reductase; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Inositol; Linear Models; Male; Neutrophils; Reference Values; Rhodanine; Sorbitol; Thiazolidines	1999

Other Studies

95 other study(ies) available for sorbitol and imidazolidines

Article	Year
CP-45,634: a novel aldose reductase inhibitor that inhibits polyol pathway activity in diabetic and galactosemic rats. Metabolism: clinical and experimental, 1979, Volume: 28, Issue:4 Suppl 1 Topics: Aldehyde Reductase; Animals; Benzopyrans; Cataract; Chromans; Diabetes Mellitus, Experimental; Galactitol; Galactose; Galactosemias; Imidazoles; Imidazolidines; Kinetics; Lens, Crystalline; Male; Polymers; Rats; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases	1979
Effects of a new aldose reductase inhibitor, (2S, 4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-ca rboxamid e (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozo Metabolism: clinical and experimental, 1992, Volume: 41, Issue:10 Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Imidazoles; Imidazolidines; Inositol; Male; Motor Neurons; Neural Conduction; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Streptozocin	1992
Effects on rat renal osmolytes of extended treatment with an aldose reductase inhibitor. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1992, Volume: 103, Issue:3 Topics: Aldehyde Reductase; Animals; Betaine; Body Weight; Imidazoles; Imidazolidines; Kidney; Male; Osmolar Concentration; Rats; Rats, Wistar; Sorbitol; Time Factors; Urine	1992
Modulation of myo-[3H]inositol uptake by glucose and sorbitol in cultured bovine lens epithelial cells. I. Restoration of myo-inositol uptake by aldose reductase inhibition. Investigative ophthalmology & visual science, 1992, Volume: 33, Issue:13 Topics: Aldehyde Reductase; Animals; Biological Transport; Cattle; Cells, Cultured; Deoxyglucose; Epithelium; Glucose; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Meglumine; Sodium; Sorbitol	1992
Modulation of myo-[3H]inositol uptake by glucose and sorbitol in cultured bovine lens epithelial cells. II. Characterization of high- and low-affinity myo-inositol transport sites. Investigative ophthalmology & visual science, 1992, Volume: 33, Issue:13 Topics: Aldehyde Reductase; Animals; Binding Sites; Biological Transport; Cattle; Cells, Cultured; Epithelium; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Lens, Crystalline; Sorbitol	1992
Sorbinil does not prevent hyperfiltration, elevated ultrafiltration pressure and albuminuria in streptozotocin-diabetic rats. Diabetologia, 1992, Volume: 35, Issue:5 Topics: Albuminuria; Aldehyde Reductase; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Glomerular Filtration Rate; Imidazoles; Imidazolidines; Kidney; Kidney Cortex; Kidney Tubules, Proximal; Male; Nephrons; Rats; Rats, Inbred Strains; Reference Values; Sorbitol; Ultrafiltration	1992
Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors. Journal of medicinal chemistry, 1992, Jun-12, Volume: 35, Issue:12 Topics: Aldehyde Reductase; Animals; Chromans; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Glycolates; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Molecular Conformation; Molecular Structure; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Stereoisomerism; Structure-Activity Relationship; X-Ray Diffraction	1992
Measurements of tissue sorbitol in diabetes mellitus: enzyme method versus gas-liquid chromatography. Metabolism: clinical and experimental, 1992, Volume: 41, Issue:2 Topics: Aldehyde Reductase; Analysis of Variance; Animals; Chromatography, Gas; Diabetes Mellitus; Diabetes Mellitus, Experimental; Erythrocytes; Humans; Hyperglycemia; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Spectrometry, Fluorescence; Sugar Alcohols	1992
Adenosine triphosphatase activity in sciatic nerve tissue of streptozocin-induced diabetic rats with and without high dietary sucrose: effect of aldose reductase inhibitors. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1991, Volume: 197, Issue:2 Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sucrose	1991
[Diabetic neuropathy--pathogenesis and precipitating factors]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49 Suppl Topics: Alcohol Drinking; Animals; Diabetic Neuropathies; Energy Metabolism; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Risk Factors; Smoking; Sodium-Potassium-Exchanging ATPase; Sorbitol	1991
The role of polyols in cerebral cell volume regulation in hypernatremic and hyponatremic states. Life sciences, 1991, Volume: 49, Issue:9 Topics: Aldehyde Reductase; Analysis of Variance; Animals; Brain; Electrolytes; Hypernatremia; Hyponatremia; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sorbitol; Vasopressins; Water-Electrolyte Balance	1991
Properties of novel aldose reductase inhibitors, M16209 and M16287, in comparison with known inhibitors, ONO-2235 and sorbinil. Chemical & pharmaceutical bulletin, 1991, Volume: 39, Issue:6 Topics: Aldehyde Reductase; Animals; Benzofurans; Cataract; Cattle; Diabetic Neuropathies; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Rhodanine; Sorbitol; Thiazolidines	1991
Sorbitol, myo-inositol, and rod outer segment phagocytosis in cultured hRPE cells exposed to glucose. In vitro model of myo-inositol depletion hypothesis of diabetic complications. Diabetes, 1991, Volume: 40, Issue:10 Topics: Adult; Aldehyde Reductase; Cells, Cultured; Diabetic Retinopathy; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Middle Aged; Phagocytosis; Pigment Epithelium of Eye; Rod Cell Outer Segment; Sorbitol	1991
[Aldose reductase inhibitors]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:9 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus; Flavonoids; Fructose; Glucose; Glutarates; Humans; Imidazoles; Imidazolidines; Sorbitol; Structure-Activity Relationship; Substrate Specificity	1991
Nonosmotic diabetic cataracts. Pediatric research, 1990, Volume: 27, Issue:3 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Sorbitol; Streptozocin; Sugar Alcohol Dehydrogenases; Taurine	1990
Sorbitol pathway activity and utilization of polyols in astroglia-rich primary cultures. Glia, 1990, Volume: 3, Issue:4 Topics: Aldehyde Reductase; Animals; Astrocytes; Cell Division; Cells, Cultured; Culture Media; DNA Replication; Energy Metabolism; Fructose; Glioma; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Neuroblastoma; Neurons; Rats; Rats, Inbred Strains; Sorbitol; Tumor Cells, Cultured; Xylitol	1990
Modulation of osmolytes in MDCK cells by solutes, inhibitors, and vasopressin. The American journal of physiology, 1990, Volume: 259, Issue:4 Pt 2 Topics: Animals; Cell Line; Glucose; Glycerylphosphorylcholine; Imidazoles; Imidazolidines; Inositol; Kidney; Phlorhizin; Sodium Chloride; Sorbitol; Vasopressins; Water-Electrolyte Balance	1990
A sodium-pump defect in diabetic peripheral nerve corrected by sorbinil administration: relationship to myo-inositol metabolism and nerve conduction slowing. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Energy Metabolism; Humans; Imidazoles; Imidazolidines; Inositol; Ion Channels; Neural Conduction; Peripheral Nerves; Rats; Rats, Inbred BB; Sodium; Sodium-Potassium-Exchanging ATPase; Sorbitol	1986
Studies of sorbinil on axonal transport in streptozotocin-diabetic rats. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Animals; Axonal Transport; Blood Glucose; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazolidines; Inositol; Male; Phospholipids; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol	1986
Defects of axonal transport in experimental diabetes that are unrelated to the sorbitol pathway. Experimental neurology, 1987, Volume: 96, Issue:1 Topics: Aldehyde Reductase; Animals; Axonal Transport; Blood Glucose; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Peripheral Nerves; Phosphofructokinase-1; Rats; Rats, Inbred Strains; Sorbitol	1987
The effect of elevated glucose levels on myo-inositol metabolism in cultured bovine aortic endothelial cells. Metabolism: clinical and experimental, 1989, Volume: 38, Issue:1 Topics: Aldehyde Reductase; Animals; Aorta; Cattle; Cell Membrane; Cells, Cultured; Endothelium, Vascular; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Phospholipids; Sorbitol	1989
Effects of aldose reductase inhibitor sorbinil on neuroaxonal dystrophy and levels of myo-inositol and sorbitol in sympathetic autonomic ganglia of streptozocin-induced diabetic rats. Diabetes, 1989, Volume: 38, Issue:5 Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Galactose; Ganglia, Sympathetic; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases	1989
Sorbinil suppresses glomerular prostaglandin production in the streptozotocin diabetic rat. Metabolism: clinical and experimental, 1989, Volume: 38, Issue:7 Topics: 6-Ketoprostaglandin F1 alpha; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dinoprostone; Female; Fructose; Glomerular Filtration Rate; Imidazoles; Imidazolidines; Kidney; Kidney Glomerulus; Organ Size; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Reference Values; Sorbitol; Sugar Alcohol Dehydrogenases	1989
Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors. Diabetes, 1989, Volume: 38, Issue:10 Topics: Albuminuria; Aldehyde Reductase; Animals; Cardiac Output; Diabetes Mellitus, Experimental; Fluorenes; Glomerular Filtration Rate; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Iodine Radioisotopes; Male; Naphthalenes; Rats; Rats, Inbred Strains; Reference Values; Regional Blood Flow; Serum Albumin, Bovine; Sorbitol; Strontium; Sugar Alcohol Dehydrogenases; Vascular Resistance	1989
Effects of sorbinil on glomerular structure and function in long-term-diabetic rats. Diabetes, 1989, Volume: 38, Issue:7 Topics: Aldehyde Reductase; Animals; Basement Membrane; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dietary Proteins; Imidazoles; Imidazolidines; Kidney Cortex; Kidney Glomerulus; Male; Microscopy, Electron; Rats; Rats, Inbred Lew; Sorbitol; Streptozocin	1989
Reversible sodium pump defect and swelling in the diabetic rat erythrocyte: effects on filterability and implications for microangiopathy. Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:9 Topics: Adenosine Triphosphate; Animals; Cytosol; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Erythrocyte Deformability; Erythrocyte Indices; Erythrocytes; Hematocrit; Imidazoles; Imidazolidines; Insulin; Kinetics; Male; Osmotic Fragility; Ouabain; Phosphorylation; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Sodium; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Sorbitol	1989
[Abnormal inositol phospholipid metabolism as a main factor causing pericyte drop-out in diabetic retinopathy]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1989, Volume: 11, Issue:6 Topics: Aldehyde Reductase; Animals; Cattle; Cell Line; Diabetic Retinopathy; Glucose; Imidazoles; Imidazolidines; Inositol; Phosphatidylinositols; Sorbitol	1989
Na+-K+-ATPase pumping activity is not directly linked to myo-inositol levels after sorbinil treatment in lenses of diabetic rats. Diabetes, 1987, Volume: 36, Issue:12 Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Glutathione; Imidazoles; Imidazolidines; Inositol; Kinetics; Lens, Crystalline; Male; Ouabain; Rats; Rats, Inbred Strains; Rubidium; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases	1987
Effect of a new aldose reductase inhibitor, 8'-chloro-2',3'-dihydrospiro [pyrrolidine-3,6'(5'H)-pyrrolo[1,2,3-de] [1,4]benzoxazine]-2,5,5'- trione (ADN-138), on delayed motor nerve conduction velocity in streptozotocin-diabetic rats. Metabolism: clinical and experimental, 1988, Volume: 37, Issue:2 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Motor Neurons; Neural Conduction; Oxazines; Pyrroles; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases	1988
Lens metabolism and cellular effects of aldose reductase. Diabetic medicine : a journal of the British Diabetic Association, 1985, Volume: 2, Issue:3 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazolidines; Lens, Crystalline; Rats; Sorbitol; Sugar Alcohol Dehydrogenases	1985
Axonal transport and nerve conduction velocity in animal models of diabetic neuropathy. Diabetic medicine : a journal of the British Diabetic Association, 1985, Volume: 2, Issue:3 Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazolidines; Inositol; Motor Neurons; Neural Conduction; Rats; Sorbitol	1985
Recent advances in the therapy of diabetic peripheral neuropathy by means of an aldose reductase inhibitor. The American journal of medicine, 1985, Nov-15, Volume: 79, Issue:5A Topics: Aldehyde Reductase; Animals; Biological Transport; Diabetic Neuropathies; Humans; Imidazoles; Imidazolidines; Inositol; Neural Conduction; Peripheral Nerves; Peripheral Nervous System Diseases; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases	1985
Experimental diabetes mellitus impairs the function of the retinal pigmented epithelium. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; Glucose; Imidazoles; Imidazolidines; Inositol; Pigment Epithelium of Eye; Rabbits; Rats; Retina; Sodium; Sodium-Potassium-Exchanging ATPase; Sorbitol	1986
Aldose reductase inhibition, glomerular metabolism, and diabetic nephropathy. Diabetic medicine : a journal of the British Diabetic Association, 1985, Volume: 2, Issue:3 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Imidazoles; Imidazolidines; Inositol; Kidney Glomerulus; Rats; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases	1985
The effect of high glucose and oxidative stress on lens metabolism, aldose reductase, and senile cataractogenesis. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Cataract; Cell Membrane; Diabetes Complications; Glucose; Glycerophosphates; Humans; Imidazoles; Imidazolidines; Lens, Crystalline; Magnetic Resonance Spectroscopy; NADP; Oxidation-Reduction; Rats; Sorbitol; Sugar Alcohol Dehydrogenases	1986
Sorbinil: a member of the novel class of spirohydantoin aldose reductase inhibitors. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Aldehyde Reductase; Animals; Chemical Phenomena; Chemistry; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Rats; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases	1986
The effect of aldose reductase and its inhibition on sugar cataract formation. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Lens, Crystalline; Mice; NADP; Osmotic Pressure; Oxidation-Reduction; Rabbits; Rats; Rodentia; Sorbitol; Sugar Alcohol Dehydrogenases	1986
Effects of the aldose reductase inhibitor sorbinil on the isolated cultured rat lens. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Hyperglycemia; Imidazoles; Imidazolidines; Lens, Crystalline; Male; Organ Culture Techniques; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases; Xylitol	1986
Study of aldose reductase inhibition in intact lenses by 13C nuclear magnetic resonance spectroscopy. Science (New York, N.Y.), 1986, Jul-11, Volume: 233, Issue:4760 Topics: Acetaminophen; Aldehyde Reductase; Animals; Ibuprofen; Imidazoles; Imidazolidines; Lens, Crystalline; Magnetic Resonance Spectroscopy; Naphthalenes; Organ Culture Techniques; Rabbits; Sorbitol; Sugar Alcohol Dehydrogenases	1986
Effects of hyperglycaemia and sorbitol accumulation on erythrocyte deformability in diabetes mellitus. Journal of clinical pathology, 1986, Volume: 39, Issue:7 Topics: Adult; Aged; Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Erythrocyte Deformability; Female; Glucose; Humans; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Middle Aged; Osmolar Concentration; Sorbitol	1986
The polyol pathway and glucose 6-phosphate in human endothelial cells cultured in high glucose concentrations. Diabetologia, 1987, Volume: 30, Issue:4 Topics: Aldehyde Reductase; Cell Division; Cells, Cultured; Chromatography, Gas; Chromatography, High Pressure Liquid; Endothelium; Glucose; Glucose-6-Phosphate; Glucosephosphates; Glycosylation; Humans; Imidazoles; Imidazolidines; Sorbitol; Sugar Alcohols; Xylitol	1987
Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy. The New England journal of medicine, 1988, Sep-01, Volume: 319, Issue:9 Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Diabetes Mellitus; Diabetic Neuropathies; Erythrocytes; Female; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Male; Middle Aged; Myelin Sheath; Nerve Regeneration; Nerve Tissue; Sorbitol; Sural Nerve	1988
Increased nerve polyol levels in experimental diabetes and their reversal by Sorbinil. British journal of experimental pathology, 1988, Volume: 69, Issue:5 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Time Factors	1988
Sorbitol generation and its inhibition by Sorbinil in the aging normal human and rabbit lens and human diabetic cataracts. Ophthalmic research, 1988, Volume: 20, Issue:6 Topics: Adolescent; Adult; Aged; Animals; Cataract; Child; Child, Preschool; Humans; Imidazoles; Imidazolidines; Lens, Crystalline; Magnetic Resonance Spectroscopy; Middle Aged; Rabbits; Sorbitol	1988
Effect of sorbinil on myo-inositol metabolism in cultured neuroblastoma cells exposed to increased glucose levels. Journal of neurochemistry, 1988, Volume: 51, Issue:2 Topics: Animals; Cell Line; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Mice; Neuroblastoma; Sorbitol; Tumor Cells, Cultured	1988
Sorbinil partially prevents decreased erythrocyte deformability in experimental diabetes mellitus. Diabetes, 1987, Volume: 36, Issue:9 Topics: Animals; Diabetes Mellitus, Experimental; Erythrocyte Deformability; Erythrocytes; Imidazoles; Imidazolidines; Male; Rats; Sorbitol	1987
Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. Diabetes, 1985, Volume: 34, Issue:1 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Microscopy, Electron, Scanning; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases	1985
Treatment with aldose reductase inhibitor or with myo-inositol arrests deterioration of the electroretinogram of diabetic rats. The Journal of clinical investigation, 1985, Volume: 76, Issue:2 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Electrophysiology; Imidazoles; Imidazolidines; Inositol; Male; Pigment Epithelium of Eye; Rats; Sorbitol; Sugar Alcohol Dehydrogenases	1985
Activated and unactivated forms of human erythrocyte aldose reductase. Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:21 Topics: Aldehyde Reductase; Diabetes Mellitus; Enzyme Activation; Erythrocytes; Glucose; Glyceraldehyde; Humans; Imidazoles; Imidazolidines; Isoquinolines; Kinetics; NADP; Quercetin; Sorbitol; Sugar Alcohol Dehydrogenases	1985
The effects of glucose and an aldose reductase inhibitor on the sorbitol content and collagen synthesis of bovine retinal capillary pericytes in culture. Experimental eye research, 1985, Volume: 40, Issue:3 Topics: Aldehyde Reductase; Animals; Capillaries; Cattle; Cells, Cultured; Collagen; Glucose; Imidazoles; Imidazolidines; Retinal Vessels; Sorbitol; Sugar Alcohol Dehydrogenases	1985
High-performance liquid chromatographic analysis of glucose, fructose, sorbitol and low levels of the aldose reductase inhibitor sorbinil in human lens and plasma. Journal of chromatography, 1985, Oct-11, Volume: 343, Issue:2 Topics: Aldehyde Reductase; Blood Glucose; Chromatography, High Pressure Liquid; Fructose; Glucose; Imidazoles; Imidazolidines; Lens, Crystalline; Sorbitol; Sugar Alcohol Dehydrogenases	1985
Diabetes-induced increases in vascular permeability and changes in granulation tissue levels of sorbitol, myo-inositol, chiro-inositol, and scyllo-inositol are prevented by sorbinil. Metabolism: clinical and experimental, 1986, Volume: 35, Issue:4 Suppl 1 Topics: Adolescent; Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Granulation Tissue; Humans; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sorbitol; Stereoisomerism	1986
Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil. Diabetes, 1984, Volume: 33, Issue:5 Topics: Aldehyde Reductase; Animals; Axonal Transport; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazolidines; Inositol; Male; Neural Conduction; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol	1984
Diabetic complications in lens and nerve and their prevention by sulindac or sorbinil: two novel aldose reductase inhibitors. Investigative ophthalmology & visual science, 1983, Volume: 24, Issue:10 Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Diabetic Retinopathy; Imidazoles; Imidazolidines; Indenes; Lens, Crystalline; Rabbits; Rats; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Sulindac	1983
Polyol pathway activity and myo-inositol metabolism. A suggested relationship in the pathogenesis of diabetic neuropathy. Diabetes, 1983, Volume: 32, Issue:11 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohols	1983
Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition. Diabetologia, 1983, Volume: 25, Issue:4 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Neural Conduction; Peripheral Nerves; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases	1983
Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil. Diabetes, 1984, Volume: 33, Issue:6 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Inositol; Kidney Glomerulus; Male; Proteins; Rats; Sorbitol; Sugar Alcohol Dehydrogenases	1984
The effects of aldose reductase inhibition on nerve sorbitol and myoinositol concentrations in diabetic and galactosemic rats. Metabolism: clinical and experimental, 1984, Volume: 33, Issue:12 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Female; Galactosemias; Imidazoles; Imidazolidines; Inositol; Peripheral Nerves; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases	1984
Aldose reductase in diabetic cataracts. JAMA, 1981, Jul-17, Volume: 246, Issue:3 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus; Humans; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Lens, Crystalline; Rats; Sorbitol; Sugar Alcohol Dehydrogenases	1981
[Effects of M79175, an aldose reductase inhibitor, on experimental sugar cataracts]. Nippon Ganka Gakkai zasshi, 1982, Volume: 86, Issue:9 Topics: Aldehyde Reductase; Animals; Cataract; Cattle; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Lens, Crystalline; Male; Rats; Sorbitol; Sugar Alcohol Dehydrogenases	1982
The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats. Diabetes, 1982, Volume: 31, Issue:9 Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Female; Imidazoles; Imidazolidines; Motor Neurons; Neural Conduction; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Time Factors	1982
Sorbitol, inositol and nerve conduction in diabetes. Life sciences, 1983, Apr-25, Volume: 32, Issue:17 Topics: Animals; Diabetes Mellitus; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Mice; Mice, Inbred C57BL; Neural Conduction; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol	1983
Has one diabetic complication been explained? The New England journal of medicine, 1983, Jan-20, Volume: 308, Issue:3 Topics: Animals; Axons; Diabetes Mellitus; Diabetic Neuropathies; Fructose; Humans; Imidazoles; Imidazolidines; Neural Conduction; Rabbits; Schwann Cells; Sorbitol	1983
Regulation of growth factor mRNA levels in the eyes of diabetic rats. Metabolism: clinical and experimental, 1995, Volume: 44, Issue:8 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Retinopathy; Eye; Fibroblast Growth Factor 2; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Insulin-Like Growth Factor I; Kidney; Lens, Crystalline; Lung; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sorbitol; Streptozocin	1995
Effects of glucose and SNK-860, an aldose reductase inhibitor, on the polyol pathway and chemiluminescence response of human neutrophils in vitro. Diabetic medicine : a journal of the British Diabetic Association, 1995, Volume: 12, Issue:5 Topics: Adult; Aldehyde Reductase; Blood Glucose; Case-Control Studies; Galactose; Glucose; Humans; Imidazoles; Imidazolidines; Luminescent Measurements; Mannitol; Neutrophils; Reference Values; Sorbitol; Tetradecanoylphorbol Acetate	1995
Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. Diabetes, 1993, Volume: 42, Issue:2 Topics: Aldehyde Reductase; Amino Acid Oxidoreductases; Animals; Arginine; Benzothiazoles; Blood Pressure; Body Weight; Capillary Permeability; Citrulline; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glycation End Products, Advanced; Guanidines; Imidazoles; Imidazolidines; Inositol; Iodine Radioisotopes; Male; Methylguanidine; Naphthalenes; Nitric Oxide Synthase; omega-N-Methylarginine; Phthalazines; Rats; Rats, Sprague-Dawley; Retina; Sciatic Nerve; Serum Albumin, Bovine; Sorbitol; Thiazoles; Uvea	1993
Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta. Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:2 Topics: Acetylcholine; Adenosine Diphosphate; Aldehyde Reductase; Animals; Aorta; Blood Glucose; Body Weight; Cyclic GMP; Diabetes Mellitus, Experimental; Endothelium, Vascular; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Prostaglandins; Rabbits; Sorbitol	1993
Transphosphatidylation of sugar alcohols and its implications for the pathogenesis of diabetic complications. Diabetologia, 1994, Volume: 37, Issue:11 Topics: Aldehyde Reductase; Animals; Brain; Cell Line; Cells, Cultured; Chromatography, Gas; Chromatography, Thin Layer; Diabetes Mellitus, Experimental; Humans; Imidazoles; Imidazolidines; Phosphatidic Acids; Phospholipase D; Phospholipids; Pigment Epithelium of Eye; Rats; Sorbitol; Synaptosomes	1994
Polyol pathway mediates high glucose-induced collagen synthesis in proximal tubule. Kidney international, 1994, Volume: 45, Issue:3 Topics: Aldehyde Reductase; Animals; Cell Line; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Collagen; Gene Expression; Genes, Reporter; Glucose; Imidazoles; Imidazolidines; Kidney Tubules, Proximal; Mice; RNA, Messenger; Sorbitol; Transcriptional Activation; Transfection	1994
Aldose reductase gene expression and osmotic dysregulation in cultured human retinal pigment epithelial cells. The American journal of physiology, 1993, Volume: 265, Issue:3 Pt 1 Topics: Aldehyde Reductase; Blood Glucose; Cell Line; Fructose; Gene Expression; Glucose; Humans; Hyperglycemia; Imidazoles; Imidazolidines; Inositol; Mannitol; Osmolar Concentration; Osmosis; Pigment Epithelium of Eye; Sorbitol; Time Factors; Water-Electrolyte Balance	1993
Acetyl-L-carnitine corrects electroretinographic deficits in experimental diabetes. Diabetes, 1993, Volume: 42, Issue:8 Topics: Acetylcarnitine; Aldehyde Reductase; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; Erythrocytes; Imidazoles; Imidazolidines; Male; Rats; Rats, Wistar; Sorbitol	1993
Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat. Diabetologia, 1993, Volume: 36, Issue:7 Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Neural Conduction; Osmolar Concentration; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Taurine	1993
Polyol pathway, 2,3-diphosphoglycerate in erythrocytes and diabetic neuropathy in rats. European journal of pharmacology, 1995, Dec-27, Volume: 294, Issue:1 Topics: 2,3-Diphosphoglycerate; Aldehyde Reductase; Animals; Body Weight; Diabetic Neuropathies; Diphosphoglyceric Acids; Enzyme Inhibitors; Erythrocytes; Imidazoles; Imidazolidines; Male; Motor Neurons; Neural Conduction; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol	1995
Localization and regulation of renal Na+/myo-inositol cotransporter in diabetic rats. Kidney international, 1996, Volume: 50, Issue:4 Topics: 3-O-Methylglucose; Aldehyde Reductase; Animals; Base Sequence; Blood Glucose; Carrier Proteins; Diabetes Mellitus, Experimental; Heat-Shock Proteins; Hypoglycemic Agents; Imidazoles; Imidazolidines; In Situ Hybridization; Inositol; Insulin, Isophane; Kidney Cortex; Kidney Medulla; Loop of Henle; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sorbitol; Symporters; Time Factors	1996
Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats. Experimental physiology, 1995, Volume: 80, Issue:6 Topics: Aldehyde Reductase; Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Electroretinography; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Sprague-Dawley; Retina; Sorbitol	1995
Endothelial dysfunction in diabetes mellitus. Prostaglandins, leukotrienes, and essential fatty acids, 1996, Volume: 54, Issue:1 Topics: Aldehyde Reductase; Animals; Capillary Permeability; Coloring Agents; Diabetes Mellitus, Experimental; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Evans Blue; Female; Guanidines; Imidazoles; Imidazolidines; Nitric Oxide; Rats; Rats, Sprague-Dawley; Serum Albumin; Sorbitol	1996
Comparison of the effects of Zopolrestat and Sorbinil on lens myo-inositol influx. Pharmacology, 1997, Volume: 54, Issue:2 Topics: Aldehyde Reductase; Animals; Benzothiazoles; Carbohydrate Metabolism; Carbohydrates; Culture Media; Enzyme Inhibitors; Galactose; Glucose; Imidazoles; Imidazolidines; In Vitro Techniques; Inositol; Lens, Crystalline; Male; Phthalazines; Polymers; Rats; Rats, Sprague-Dawley; Sorbitol; Thiazoles	1997
Fructose-3-phosphate production and polyol pathway metabolism in diabetic rat hearts. Metabolism: clinical and experimental, 1997, Volume: 46, Issue:11 Topics: Administration, Oral; Ampholyte Mixtures; Animals; Chromatography, High Pressure Liquid; Cohort Studies; Deoxyglucose; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructose; Fructosephosphates; Gas Chromatography-Mass Spectrometry; Glucose; Imidazoles; Imidazolidines; Lens, Crystalline; Magnetic Resonance Spectroscopy; Male; Myocardium; Perchlorates; Phosphorus Isotopes; Polymers; Rats; Rats, Sprague-Dawley; Sorbitol	1997
Depletion of phospholipid arachidonoyl-containing molecular species in a human Schwann cell line grown in elevated glucose and their restoration by an aldose reductase inhibitor. Journal of neurochemistry, 1998, Volume: 71, Issue:2 Topics: Aldehyde Reductase; Arachidonic Acid; Benzothiazoles; Cell Division; Culture Media; Enzyme Inhibitors; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Mannitol; Neurofibroma; Organic Chemicals; Phospholipids; Phthalazines; Piperazines; Pyrimidines; Schwann Cells; Sorbitol; Thiazoles; Tumor Cells, Cultured	1998
Renal proximal tubular cell fibronectin accumulation in response to glucose is polyol pathway dependent. Kidney international, 1999, Volume: 55, Issue:1 Topics: Aldehyde Reductase; Animals; Basement Membrane; Diabetic Nephropathies; Enzyme Inhibitors; Fibronectins; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Kidney Tubules, Proximal; LLC-PK1 Cells; Sorbitol; Swine	1999
Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats. Diabetes research and clinical practice, 2000, Volume: 50, Issue:2 Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Fructose; Glycated Hemoglobin; Imidazoles; Imidazolidines; Inositol; Male; Myelin Sheath; Nerve Fibers; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol; Sural Nerve; Tibial Nerve; Time Factors	2000
Evaluation of an aldose reductase inhibitor on lens metabolism, ATPases and antioxidative defense in streptozotocin-diabetic rats: an intervention study. Diabetologia, 2000, Volume: 43, Issue:8 Topics: Adenine Nucleotides; Adenosine Triphosphatases; Aldehyde Reductase; Animals; Antioxidants; Ca(2+) Mg(2+)-ATPase; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; NAD; NADP; Proton-Translocating ATPases; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Sorbitol	2000
Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy. Pharmacology, 2001, Volume: 62, Issue:3 Topics: Adrenergic alpha-Antagonists; Ammonia; Animals; Antioxidants; Cell Fractionation; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructose; Glucose; Glutamic Acid; Imidazoles; Imidazolidines; Ketoglutaric Acids; Lactic Acid; Male; Mitochondria; NAD; Oxidation-Reduction; Piperazines; Prazosin; Pyrimidines; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Retina; Sorbitol; Thioctic Acid	2001
Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes. Pharmacology, 2001, Volume: 62, Issue:4 Topics: Age Factors; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Fasting; Female; Glycated Hemoglobin; Humans; Imidazoles; Imidazolidines; Male; Rats; Rats, Sprague-Dawley; Rhodanine; Sciatic Nerve; Sex Factors; Sorbitol; Thiazolidines	2001
Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes. Diabetes, 2002, Volume: 51, Issue:10 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Glucose; Imidazoles; Imidazolidines; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Sprague-Dawley; Sorbitol	2002
Sorbitol dehydrogenase overexpression potentiates glucose toxicity to cultured retinal pericytes. Biochemical and biophysical research communications, 2002, Nov-29, Volume: 299, Issue:2 Topics: Aldehyde Reductase; Animals; Blood-Retinal Barrier; Capillary Permeability; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; DNA; Endothelial Growth Factors; Enzyme Inhibitors; Fructose; Glucose; Imidazoles; Imidazolidines; Intercellular Signaling Peptides and Proteins; L-Iditol 2-Dehydrogenase; Lymphokines; Male; Pericytes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retina; RNA, Messenger; Sorbitol; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2002
Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats. Diabetes, 2003, Volume: 52, Issue:3 Topics: Aldehyde Reductase; Angiogenesis Inducing Agents; Animals; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Flow Cytometry; Fructose; Gene Expression; Glucose; Glutathione; Glutathione Peroxidase; Imidazoles; Imidazolidines; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Retina; Retinal Vessels; RNA, Messenger; Sorbitol; Superoxide Dismutase; Vascular Endothelial Growth Factor A	2003
Suppression of 3-deoxyglucosone and heparin-binding epidermal growth factor-like growth factor mRNA expression by an aldose reductase inhibitor in rat vascular smooth muscle cells. Biochemical and biophysical research communications, 2004, Feb-06, Volume: 314, Issue:2 Topics: Aldehyde Reductase; Animals; Blotting, Northern; Cells, Cultured; Deoxyglucose; Enzyme Inhibitors; Epidermal Growth Factor; Glucose; Glycation End Products, Advanced; Heparin-binding EGF-like Growth Factor; Imidazoles; Imidazolidines; Intercellular Signaling Peptides and Proteins; Mitogens; Muscle, Smooth, Vascular; Oxidative Stress; Rats; RNA, Messenger; Sorbitol; Thiobarbituric Acid Reactive Substances; Thymidine	2004
Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy. Diabetes, 2004, Volume: 53, Issue:9 Topics: Aged; Aldehyde Reductase; Animals; Apoptosis; Capillaries; Diabetic Retinopathy; Enzyme Inhibitors; Female; Glucose; Humans; Imidazoles; Imidazolidines; Male; Middle Aged; Pericytes; Polymers; Rats; Rats, Sprague-Dawley; Retinal Vessels; Sorbitol	2004
Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications. Diabetes, 2005, Volume: 54, Issue:1 Topics: Aldehyde Reductase; Animals; Aorta; Arterioles; Cattle; Diabetes Mellitus, Experimental; Endothelium, Vascular; Fructose; Imidazolidines; Male; Motor Neurons; Neural Conduction; Neurons, Afferent; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Tyrosine	2005
The role of polyol pathway in high glucose-induced endothelial cell damages. Diabetes research and clinical practice, 2006, Volume: 73, Issue:3 Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehyde Reductase; Carbohydrate Metabolism; Caspase 3; Cells, Cultured; Culture Media; Deoxyguanosine; DNA Fragmentation; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Glucose; Humans; Imidazolidines; Polymers; Signal Transduction; Sorbitol	2006
Role of nitric oxide in regulating aldose reductase activation in the ischemic heart. The Journal of biological chemistry, 2008, Apr-04, Volume: 283, Issue:14 Topics: Aldehyde Reductase; Animals; Bradykinin; Dithiothreitol; Enzyme Activation; Enzyme Inhibitors; Ferric Compounds; Glucose; Hesperidin; Hypoglycemic Agents; Imidazolidines; Insulin; Lipid Peroxidation; Male; Metalloporphyrins; Myocardial Reperfusion Injury; Myocardium; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sorbitol; Vasodilator Agents	2008
Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo. Current eye research, 2010, Volume: 35, Issue:2 Topics: Acridine Orange; Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium, Vascular; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Fluorophotometry; Fructose; Imidazolidines; Intercellular Adhesion Molecule-1; Leukocytes; Male; Microscopy, Fluorescence; Rats; Rats, Long-Evans; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sorbitol; Vascular Endothelial Growth Factor A	2010
Evaluation of the aldose reductase inhibitor fidarestat on ischemia-reperfusion injury in rat retina. International journal of molecular medicine, 2010, Volume: 26, Issue:1 Topics: Aldehyde Reductase; Animals; Apoptosis; Blotting, Western; Drug Evaluation, Preclinical; Female; Fructose; Glucose; Imidazolidines; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intravenous; L-Iditol 2-Dehydrogenase; Rats; Rats, Wistar; Reperfusion Injury; Retina; Sorbitol	2010
Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy. Biochemical pharmacology, 2012, Apr-01, Volume: 83, Issue:7 Topics: Aldehyde Reductase; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Blood Glucose; Blotting, Western; Calcium; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme-Linked Immunosorbent Assay; Fructose; Ganglia, Spinal; Imidazolidines; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphorylation; Sciatic Nerve; Sorbitol; Spinal Cord; Streptozocin	2012