sorbitol has been researched along with epalrestat in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (21.21) | 18.7374 |
| 1990's | 16 (48.48) | 18.2507 |
| 2000's | 5 (15.15) | 29.6817 |
| 2010's | 4 (12.12) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Aida, K; Onaya, T; Shindo, H; Tawata, M | 1 |
| Nakashima, M; Takiguchi, Y; Wada, K | 1 |
| Awaya, S; Fukasawa, H; Hotta, N; Kakuta, H; Koh, N; Sakamoto, N; Yasuma, T | 1 |
| Inoue, M; Noguchi, T; Onaya, T; Shindo, H; Tawata, M; Wakasugi, M | 1 |
| Eto, M; Ishii, K; Iwashima, Y; Makino, I; Morikawa, A; Sekiguchi, M; Takahashi, M; Watanabe, K | 1 |
| Kamon, N; Mabuchi, H; Takeda, R; Terashima, H | 1 |
| Kato, K; Miwa, I; Mizota, M; Nakayama, K; Okuda, J | 1 |
| Iwamoto, Y | 1 |
| Hatanaka, I; Huitian, Z; Shigeta, Y; Sonobe, M; Terada, M; Yamashita, M; Yasuda, H | 1 |
| Kondo, M; Nakano, K; Nishioka, H; Terashima, H; Yoshida, T; Yoshioka, K | 1 |
| Fukasawa, H; Hotta, N; Iida, M; Kakuta, H; Kimura, M; Koh, N; Morimura, T; Sakamoto, N; Terashima, H | 1 |
| Kador, PF; Kinoshita, JH; Sharpless, NE | 1 |
| Hatanaka, I; Kikkawa, R; Kobayashi, N; Morimura, T; Shigeta, Y; Terashima, H; Tsuboshima, M; Yasuda, H | 1 |
| Hatanaka, I; Kikkawa, R; Kobayashi, N; Shigeta, Y; Yasuda, H | 1 |
| Hama, K; Hatanaka, I; Kikkawa, R; Shigeta, Y; Terashima, H; Tsuboshima, M; Yamamoto, R | 1 |
| Hotta, N; Koh, N; Sakakibara, F; Sakamoto, N | 1 |
| Inokuchi, T; Isogai, S; Ohe, K | 1 |
| Fujii, T; Fujinami, T; Ito, J; Kamiya, Y; Kawaguchi, M; Okada, M; Sakuma, N | 1 |
| Asakura, Y; Asano, M; Bannai, C; Dai, H; Kawashima, K; Okuda, Y; Saitoh, M; Suzuki, S; Tachi, Y; Tsurumaru, K; Yamashita, K | 1 |
| Eto, K; Hashimoto, K; Kanda, M; Sugiyama, A; Tanabe, N; Ueno, A | 1 |
| Aono, T; Fujita, T; Hamada, M; Hayakawa, N; Hayashi, R; Itoh, M; Kakizawa, H; Makino, M; Nagasaka, A; Nagata, M; Shinohara, R; Uchimura, K | 1 |
| Hotta, N; Kawamura, T; Sakakibara, F; Sakamoto, N; Sano, T; Sasaki, H; Suzuki, K | 1 |
| Chaya, S; Hamada, Y; Hotta, N; Kasuya, Y; Kato, K; Komori, T; Nakamura, J; Nakashima, E; Nakayama, M; Naruse, K; Sasaki, H; Watanabe, G | 1 |
| Aoki, T; Makino, M; Mizuno, K; Sassa, H; Sobajima, H; Suzuki, T; Taniko, K | 1 |
| Aoki, Y; Ikenaga, H; Ishii, N; Ogawa, Z; Saruta, T; Suga, T | 1 |
| Cheng, JT; Chin, WT; Tong, YC | 1 |
| Hayakawa, N; Itoh, M; Nagasaka, A; Nagata, M; Nakano, I; Oda, N; Sawai, Y; Shinohara, R; Suzuki, A; Takeda, F; Tsugawa, T | 1 |
| Fujiwara, H; Kajiyama, S; Kanegawa, N; Kiyono, Y; Saji, H | 1 |
| Amizuka, N; Fujie, A; Hao, W; Hasegawa, T; Katsuyama, E; Kobayashi, T; Matsumoto, M; Miyamoto, K; Miyamoto, T; Morioka, H; Morita, M; Nakamura, M; Sato, Y; Tando, T; Tashiro, S; Toyama, Y; Watanabe, R | 1 |
| Ishibashi, Y; Kato, H; Matsui, T; Matsumoto, T; Yamagishi, S | 1 |
| Cao, K; Chen, Z; Fujita, N; Hikata, T; Huang, L; Ishii, K; Iwanami, A; Luo, J; Matsumoto, M; Miyamoto, T; Nakamura, M; Pan, Z; Tsuji, T; Watanabe, K; Wu, H; Zeng, Z; Zhang, Z | 1 |
| Aa, JY; Ding, F; Gao, HX; He, J; Sun, RB; Wang, GJ; Wang, JK; Xie, Y; Yang, N; Zeng, CH; Zhang, JW; Zhu, XD | 1 |
| Brucker, W; Cassiman, D; Edmondson, AC; Garapati, K; Ghesquière, B; Johnsen, C; Kozicz, T; Krzysciak, W; Lam, C; Larson, A; Ligezka, AN; McGovern, RM; Mercimek-Andrews, S; Morava, E; Muthusamy, K; Oglesbee, D; Pandey, A; Perlstein, EO; Preston, G; Radenkovic, S; Ranatunga, W; Raymond, K; Reid, JM; Saraswat, M; Witters, P; Yanaihara, H | 1 |
1 review(s) available for sorbitol and epalrestat
| Article | Year |
|---|---|
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; Corneal Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Fluorenes; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Models, Molecular; Naphthalenes; Phthalazines; Rhodanine; Sorbitol; Structure-Activity Relationship; Substrate Specificity; Sugar Alcohol Dehydrogenases; Thiazolidines; Tissue Distribution | 1985 |
1 trial(s) available for sorbitol and epalrestat
| Article | Year |
|---|---|
Effect of aldose reductase inhibitors on glucose-induced changes in sorbitol and myo-inositol metabolism in human neutrophils.
Topics: Adult; Aldehyde Reductase; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Inositol; Linear Models; Male; Neutrophils; Reference Values; Rhodanine; Sorbitol; Thiazolidines | 1999 |
31 other study(ies) available for sorbitol and epalrestat
| Article | Year |
|---|---|
The role of cyclic adenosine 3',5'-monophosphate and polyol metabolism in diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Chalcone; Chalcones; Cyclic AMP; Cyclic GMP; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Iloprost; Inositol; Male; Neural Conduction; Rats; Rats, Inbred WKY; Rhodanine; Sciatic Nerve; Sorbitol; Thiazolidines | 1992 |
Effect of aldose reductase inhibitor on the inhibition of platelet aggregation induced by diabetic rat plasma.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Erythrocytes; In Vitro Techniques; Insulin; Male; Platelet Aggregation; Rats; Rats, Wistar; Rhodanine; Sorbitol; Thiazolidines | 1992 |
In vitro retinal and erythrocyte polyol pathway regulation by hormones and an aldose reductase inhibitor.
Topics: Aged; Aldehyde Reductase; Animals; Diabetes Mellitus; Epinephrine; Erythrocytes; Fructose; Glucose; Humans; In Vitro Techniques; Insulin; Male; Rabbits; Reference Values; Retina; Rhodanine; Sorbitol; Thiazolidines | 1991 |
Effects of aldose reductase inhibitors on prostacyclin (PGI2) synthesis by aortic rings from rats with streptozotocin-induced diabetes.
Topics: Aldehyde Reductase; Animals; Aorta, Thoracic; Blood Glucose; Chalcone; Chalcones; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Epoprostenol; Male; Rats; Rats, Inbred Strains; Rhodanine; Sciatic Nerve; Sorbitol; Streptozocin; Sugar Alcohols; Thiazolidines | 1991 |
Polyol pathway in tissues of spontaneously diabetic Chinese hamsters (Cricetulus griseus) and the effect of an aldose reductase inhibitor, ONO-2235.
Topics: Aldehyde Reductase; Animals; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Female; Fructose; Inositol; Kidney; Lens, Crystalline; Male; Polymers; Retina; Rhodanine; Sciatic Nerve; Sorbitol; Thiazolidines | 1991 |
Effects of aldose reductase inhibitor (ONO-2235) on human erythrocyte sorbitol concentrations in 75 g oral glucose tolerance tests.
Topics: Adult; Aged; Aldehyde Reductase; Blood Glucose; Erythrocytes; Female; Glucose Tolerance Test; Humans; Male; Middle Aged; Rhodanine; Sorbitol; Thiazolidines | 1991 |
Properties of novel aldose reductase inhibitors, M16209 and M16287, in comparison with known inhibitors, ONO-2235 and sorbinil.
Topics: Aldehyde Reductase; Animals; Benzofurans; Cataract; Cattle; Diabetic Neuropathies; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Rhodanine; Sorbitol; Thiazolidines | 1991 |
[Diabetic complication].
Topics: Aldehyde Reductase; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetic Nephropathies; Diabetic Neuropathies; Glycosylation; Humans; Inositol; Proteins; Rhodanine; Sorbitol; Thiazolidines | 1991 |
Effect of prostaglandin E1 analogue TFC 612 on diabetic neuropathy in streptozocin-induced diabetic rats. Comparison with aldose reductase inhibitor ONO 2235.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Alprostadil; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Electrophysiology; Inositol; Lactates; Male; Myelin Sheath; Nerve Fibers; Phosphocreatine; Rats; Rats, Inbred Strains; Rhodanine; Sciatic Nerve; Sorbitol; Streptozocin; Sugar Alcohol Dehydrogenases; Thiazoles; Thiazolidines | 1989 |
Effect of aldose reductase inhibitor ONO 2235 on reduced sympathetic nervous system activity and peripheral nerve disorders in STZ-induced diabetic rats.
Topics: Aldehyde Reductase; alpha-Methyltyrosine; Animals; Autonomic Nervous System Diseases; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Erythrocytes; Female; Methyltyrosines; Neural Conduction; Norepinephrine; Peripheral Nervous System Diseases; Rats; Rats, Inbred Strains; Rhodanine; Sciatic Nerve; Sorbitol; Streptozocin; Sugar Alcohol Dehydrogenases; Sympathetic Nervous System; Thiazoles; Thiazolidines; Triiodothyronine | 1987 |
Effects of a fructose-rich diet and the aldose reductase inhibitor, ONO-2235, on the development of diabetic neuropathy in streptozotocin-treated rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dietary Carbohydrates; Erythrocytes; Fructose; Male; Motor Neurons; Neural Conduction; Rats; Retina; Rhodanine; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Thiazoles; Thiazolidines | 1985 |
Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) on peripheral nerve disorders in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Erythrocytes; Insulin; Male; Neural Conduction; Rats; Rats, Inbred Strains; Rhodanine; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Thiazoles; Thiazolidines | 1983 |
Prevention of peripheral nerve dysfunction by an aldose reductase inhibitor in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Male; Motor Neurons; Neural Conduction; Rats; Rats, Inbred Strains; Rhodanine; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Thiazoles; Thiazolidines | 1984 |
Effects of a new aldose reductase inhibitor on various tissues in vitro.
Topics: Aldehyde Reductase; Animals; Erythrocytes; Kinetics; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Rhodanine; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Thiazoles; Thiazolidines | 1984 |
Effects of high glucose concentrations and epalrestat on sorbitol and myo-inositol metabolism in cultured rabbit aortic smooth muscle cells.
Topics: Aldehyde Reductase; Animals; Aorta; Biological Transport, Active; Cells, Cultured; Cytochalasin B; Dose-Response Relationship, Drug; Fructose; Glucagon; Glucose; Inositol; Insulin; Muscle, Smooth, Vascular; Ouabain; Rabbits; Rhodanine; Sodium; Sorbitol; Thiazolidines | 1993 |
Effect of an aldose reductase inhibitor on glomerular basement membrane anionic sites in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Albuminuria; Aldehyde Reductase; Animals; Anions; Basement Membrane; Blood Glucose; Blood Pressure; Cohort Studies; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Erythrocytes; Kidney Glomerulus; Male; Rats; Rats, Wistar; Rhodanine; Sorbitol; Thiazolidines; Time Factors | 1995 |
Effects of fructose ingestion on sorbitol and fructose 3-phosphate contents of erythrocytes from healthy men.
Topics: Adult; Aldehyde Reductase; Erythrocytes; Fructose; Fructosephosphates; Glucose; Humans; Male; Rhodanine; Sorbitol; Thiazolidines; Time Factors | 1996 |
Restoration of nitric oxide production by aldose reductase inhibitor in human endothelial cells cultured in high-glucose medium.
Topics: Aldehyde Reductase; Cells, Cultured; Culture Media; Endothelium, Vascular; Enzyme Inhibitors; Fructose; Glucose; Humans; Nitric Oxide; Rhodanine; Sorbitol; Thiazolidines; Umbilical Veins | 1997 |
Effects of ONO-2235, an aldose reductase inhibitor, on muscarinic receptors and contractile response of the urinary bladder in rats with streptozotocin-induced diabetes.
Topics: Acetylcholine; Aldehyde Reductase; Analysis of Variance; Animals; Binding, Competitive; Blood Glucose; Diabetes Mellitus, Experimental; Diuresis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperglycemia; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Receptors, Muscarinic; Rhodanine; Sciatic Nerve; Sorbitol; Thiazolidines; Tissue Preservation; Urinary Bladder | 1997 |
Changes in erythrocyte sorbitol concentrations measured using an improved assay system in patients with diabetic complications and treated with aldose reductase inhibitor.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Blood Glucose; Child; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Enzyme Inhibitors; Erythrocytes; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Regression Analysis; Reproducibility of Results; Rhodanine; Sorbitol; Spectrophotometry; Thiazolidines | 1998 |
An aldose reductase inhibitor prevents the glucose-induced increase in PDGF-beta receptor in cultured rat aortic smooth muscle cells.
Topics: Aldehyde Reductase; Animals; Antibodies; Aorta; Becaplermin; Cells, Cultured; DNA; Enzyme Inhibitors; Fructose; Glucose; Humans; Inositol; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Receptors, Platelet-Derived Growth Factor; Rhodanine; Sorbitol; Thiazolidines | 1999 |
Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes.
Topics: Age Factors; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Fasting; Female; Glycated Hemoglobin; Humans; Imidazoles; Imidazolidines; Male; Rats; Rats, Sprague-Dawley; Rhodanine; Sciatic Nerve; Sex Factors; Sorbitol; Thiazolidines | 2001 |
Effects of renal sorbitol accumulation on urinary excretion of enzymes in hyperglycaemic rats.
Topics: Acetylglucosaminidase; Analysis of Variance; Animals; Biomarkers; Blood Glucose; CD13 Antigens; Dipeptidyl Peptidase 4; Enzyme Inhibitors; gamma-Glutamyltransferase; Glomerular Filtration Rate; Glucose; Hyperglycemia; Infusions, Intravenous; Kidney; Male; Mannitol; Rats; Rats, Wistar; Rhodanine; Sorbitol; Thiazolidines; Time Factors | 2001 |
Role of sorbitol in the up-regulation of urinary bladder M(2) muscarinic receptors in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Autoradiography; Blotting, Northern; Blotting, Western; Diabetes Mellitus, Experimental; Diuretics, Osmotic; Glucose; Male; Rats; Rats, Wistar; Receptor, Muscarinic M2; Receptors, Muscarinic; Reference Values; Rhodanine; RNA, Messenger; Sorbitol; Thiazolidines; Up-Regulation; Urinary Bladder | 2002 |
Alteration of urinary sorbitol excretion in WBN-kob diabetic rats - treatment with an aldose reductase inhibitor.
Topics: Acetylglucosaminidase; Aldehyde Reductase; Animals; Diabetic Nephropathies; Kidney; Male; Models, Animal; Rats; Rats, Wistar; Rhodanine; Sorbitol; Thiazolidines | 2004 |
Influence of the polyol pathway on norepinephrine transporter reduction in diabetic cardiac sympathetic nerves: implications for heterogeneous accumulation of MIBG.
Topics: 3-Iodobenzylguanidine; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Heart; Male; Metabolic Clearance Rate; Myocardium; Norepinephrine Plasma Membrane Transport Proteins; Polymers; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Rhodanine; Signal Transduction; Sorbitol; Streptozocin; Sympathetic Nervous System; Symporters; Thiazolidines | 2005 |
Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation.
Topics: Aldehyde Reductase; Animals; Calcitriol; Cell Dedifferentiation; Cells, Cultured; Demyelinating Diseases; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Down-Regulation; Enzyme Inhibitors; Glucose; Hyperglycemia; In Vitro Techniques; Insulin-Like Growth Factor I; Mice; Mice, Inbred C57BL; Models, Neurological; Rats; Rhodanine; Schwann Cells; Sciatic Nerve; Sorbitol; Thiazolidines; Vitamin D | 2015 |
Ranirestat has a stronger inhibitory activity on aldose reductase and suppresses inflammatory reactions in high glucose-exposed endothelial cells.
Topics: Aldehyde Reductase; Anti-Inflammatory Agents; Cell Line, Tumor; Chromatography, Liquid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Inflammation Mediators; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Rhodanine; Sorbitol; Spiro Compounds; Superoxides; Tandem Mass Spectrometry; Thiazolidines; Vascular Cell Adhesion Molecule-1 | 2016 |
Increased sorbitol levels in the hypertrophic ligamentum flavum of diabetic patients with lumbar spinal canal stenosis.
Topics: Aged; Aged, 80 and over; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Case-Control Studies; Cell Cycle; Cell Proliferation; Cytokines; Diabetes Complications; Female; Fibroblasts; Glucose; Humans; Hypertrophy; Ligamentum Flavum; Lumbar Vertebrae; Male; Mice; Middle Aged; NIH 3T3 Cells; Rhodanine; Sorbitol; Spinal Stenosis; Thiazolidines | 2017 |
The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation.
Topics: Albuminuria; Aldehyde Reductase; Animals; Diabetic Nephropathies; Enzyme Inhibitors; Fructose; Inositol; Kidney; Male; Metabolomics; Mice; Protective Agents; Rhodanine; Sorbitol; Thiazolidines | 2019 |
Sorbitol Is a Severity Biomarker for PMM2-CDG with Therapeutic Implications.
Topics: Adolescent; Adult; Aged; Biomarkers; Child; Child, Preschool; Congenital Disorders of Glycosylation; Enzyme Inhibitors; Female; Glycosylation; Humans; Infant; Male; Middle Aged; Patient Acuity; Phosphotransferases (Phosphomutases); Prognosis; Rhodanine; Sorbitol; Thiazolidines; Young Adult | 2021 |