sorbitan-monooleate has been researched along with laurocapram* in 2 studies
2 other study(ies) available for sorbitan-monooleate and laurocapram
| Article | Year |
|---|---|
Dual-directional regulation of drug permeating amount by combining the technique of ion-pair complexation with chemical enhancers for the synchronous permeation of indapamide and bisoprolol in their compound patch through rabbit skin.
To achieve the synchronous skin permeation of indapamide (IND) and bisoprolol (BSP) in their compound patch, the techniques of ion-pair complexation and chemical enhancers were combined to dual-directionally regulate drug permeating amounts. Ion-pair complexes of BSP and various organic acids were formed by the technique of ion-pair complexation. Among the complexes formed, bisoprolol tartrate (BSP.T) down-regulated the permeating amount of BSP to the same extent as that of IND. Then, to simultaneously up-regulate the amounts of the two drugs, an enhancer combination of 15.8% Span80 (SP), 6.0% Azone (AZ) and 2.2% N-methyl pyrrolidone (NMP) was obtained by central composite design and exhibited an outstanding and simultaneous enhancement on IND and BSP with enhancing ratio (ER) of 4.52 and 3.49, respectively. The effect of the dual-directional regulation was evaluated by in vitro permeation experiments and in vivo pharmacokinetic studies. For IND and BSP, their observed permeation profiles were comparable and their MAT (mean absorption time) showed no significant difference, which both demonstrated these two drugs achieved the synchronous skin permeation in their compound patch by the dual-directional regulation strategy of combining the technique of ion-pair complexation with chemical enhancers. Topics: Animals; Azepines; Bisoprolol; Chemistry, Pharmaceutical; Down-Regulation; Drug Combinations; Drug Interactions; Drug Liberation; Excipients; Hexoses; In Vitro Techniques; Indapamide; Injections, Intravenous; Male; Permeability; Pyrrolidinones; Rabbits; Skin; Skin Absorption; Tartrates; Transdermal Patch; Up-Regulation | 2015 |
A pharmacokinetic model for the percutaneous absorption of indomethacin and the prediction of drug disposition kinetics.
A pharmacokinetic model with two parallel absorption processes from two fractions has been derived for the percutaneous absorption of indomethacin. The simulation includes five first-order rate constants assigned the following significance: (a) rapid absorption (ka1) and slow absorption (ka2) through the skin; and (b) distribution into the tissue and subsequent elimination from the body. The model, applied to data obtained after percutaneous dosing of ointments under occlusion, successfully described the plasma profile observed in the presence and absence of laurocapram (Azone) and sorbitan monooleate. The penetration characteristics through stripped skin were also well described by the model. It was clarified that indomethacin was absorbed via both pathways, with rapid and slow absorption rate constants at the initial time stage, and via the latter pathway at the later period. Also, laurocapram and sorbitan monooleate increased the fraction absorbed via the rapid absorption pathway by about three times, without a significant alteration of either absorption rate constant, while the enhancers gave no significant effect on either absorption pathway in the stripped skin. The results suggest that the model is simple yet adaptable enough to prove of general use for the interpretation of percutaneous absorption data. Topics: Animals; Azepines; Excipients; Hexoses; Indomethacin; Injections, Intravenous; Models, Biological; Ointments; Rats; Rats, Inbred Strains; Skin Absorption | 1989 |