sorbicillin has been researched along with bisorbicillinol* in 3 studies
3 other study(ies) available for sorbicillin and bisorbicillinol
| Article | Year |
|---|---|
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
Bisorbicillinol, which is isolated from Trichoderma sp. USF2690, is an inhibitor of β-hexosaminidase release and tumor necrosis factor (TNF)-α, and Interleukin (IL)-4 secretion from rat basophilic leukemia (RBL-2H3) cells, with IC Topics: Animals; Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Bridged-Ring Compounds; Cell Degranulation; Cell Line, Tumor; Mast Cells; Protein Kinase Inhibitors; Rats; Receptors, IgE; Signal Transduction; src-Family Kinases; Tumor Necrosis Factor-alpha | 2019 |
Stereoselective Total Synthesis of Bisorbicillinoid Natural Products by Enzymatic Oxidative Dearomatization/Dimerization.
Natural products are a virtually inexhaustible source of small molecules with spectacular molecular architectures and biomedical potential. Their structural complexity generates formidable challenges to total synthesis but often also precludes time- and resource-efficient, stereoselective synthetic access. Biosynthetically, nature frequently uses dimerization and oligomerization reactions to produce highly challenging frameworks from simple starting materials. Impressive examples are the bisorbicillinoids, a family of fungal natural products thought to originate from the polyketide precursor sorbicillin. Utilizing the recombinant oxidoreductase SorbC from the sorbicillin biosynthetic gene cluster, a robust, fully stereoselective synthesis of bisorbicillinoid natural products and unnatural side-chain analogues was developed. Topics: Biocatalysis; Biological Products; Bridged-Ring Compounds; Dimerization; Fungi; Oxidation-Reduction; Oxidoreductases; Recombinant Proteins; Resorcinols; Stereoisomerism | 2017 |
Biosynthesis of bisorbicillinoid in Trichoderma sp. USF-2690; evidence for the biosynthetic pathway, via sorbicillinol, of sorbicillin, bisorbicillinol, bisorbibutenolide, and bisorbicillinolide.
An incorporation study of [1-(13)C] and [1,2-(13)C2] labeled sodium acetates into sorbicillinol 1 established a ring closure system between C-1 and C-6 and the positions that were oxidized and/or methylated on a hexaketide chain. Subsequent investigations, using 13C-labeled 1 prepared from [1-(13)C] labeled sodium acetate, clearly demonstrated that both bisorbicillinol 2 and sorbicillin 6 incorporated 13C-labeled 1 into their carbon skeletons. 13C-labeled bisorbicillinols 2 derived from [1-(13)C]- and [2-(13)C]-labeled sodium acetates clearly indicate that these were on the biosynthetic route from 1 to bisorbibutenolide (bislongiquinolide) 3 and bisorbicillinolide 4 via 2 as a branching point in the fungus. Topics: 4-Butyrolactone; Acetylation; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Cyclohexanones; Fermentation; Magnetic Resonance Spectroscopy; Models, Molecular; Resorcinols; Trichoderma | 2002 |