Compounds > sorafenib
Page last updated: 2024-09-05

sorafenib and warfarin

sorafenib has been researched along with warfarin in 9 studies

Compound Research Comparison

Studies
(sorafenib)		Trials
(sorafenib)		Recent Studies (post-2010)
(sorafenib)		Studies
(warfarin)		Trials
(warfarin)		Recent Studies (post-2010) (warfarin)
6,5207305,25136,5732,14314,728

Protein Interaction Comparison

ProteinTaxonomysorafenib (IC50)warfarin (IC50)
Vitamin K epoxide reductase complex subunit 1 Homo sapiens (human)0.0088

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (11.11)29.6817
2010's4 (44.44)24.3611
2020's4 (44.44)2.80

Authors

AuthorsStudies
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Montalvo, RO; Moretti, LV1
Hara, F; Hirano, N; Iida, K; Ishii, K; Kikuchi, Y; Shiozawa, K; Sumino, Y; Wakui, N; Watanabe, M1
Callaghan, C; Dash, S; Lee, BR; Liu, J; Maddox, M; Mandava, SH; Peralta, D; Tarr, MA1
Jakubowicz-Gil, J; Langner, E; Maciejczyk, A; Rzeski, W; Skalicka-Woźniak, K; Sumorek-Wiadro, J; Zając, A1
Asari, K; Takahashi, H1
Cai, W; Ghim, JL; Liu, S; Parvez, M; Shin, JG; Sun, H; Tang, Z; Wang, Z; Xiang, X1
Fan, K; Huang, H; Xie, ML; Xie, T; Zhao, Y; Zhu, ZY1

Reviews

1 review(s) available for sorafenib and warfarin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

8 other study(ies) available for sorafenib and warfarin

ArticleYear
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Elevated International Normalized Ratio associated with concurrent use of sorafenib and warfarin.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2009, Dec-01, Volume: 66, Issue:23

    Topics: Aged; Anticoagulants; Benzenesulfonates; Carcinoma, Hepatocellular; Drug Interactions; Hemorrhage; Humans; International Normalized Ratio; Liver Neoplasms; Male; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyridines; Sorafenib; Warfarin

2009
[Gastrointestinal hemorrhage associated with concurrent use of sorafenib and warfarin for hepatocellular carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:10

    Topics: Anticoagulants; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Hepatocellular; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Liver Neoplasms; Male; Middle Aged; Niacinamide; Phenylurea Compounds; Pyridines; Sorafenib; Tomography, X-Ray Computed; Warfarin

2011
Combined Treatment of Tyrosine Kinase Inhibitor-Labeled Gold Nanorod Encapsulated Albumin With Laser Thermal Ablation in a Renal Cell Carcinoma Model.
    Journal of pharmaceutical sciences, 2016, Volume: 105, Issue:1

    Topics: Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Coumarins; Drug Compounding; Gold; Humans; Kidney Neoplasms; Lasers; Nanotubes; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Serum Albumin; Solubility; Sorafenib

2016
Antiglioma Potential of Coumarins Combined with Sorafenib.
    Molecules (Basel, Switzerland), 2020, Nov-08, Volume: 25, Issue:21

    Topics: 4-Hydroxycoumarins; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Beclin-1; Caspase 3; Cell Line, Tumor; Cell Proliferation; Coumarins; Esculin; Gene Expression Regulation; Glioblastoma; Humans; Magnoliopsida; Necrosis; Phosphatidylinositol 3-Kinases; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; raf Kinases; RNA, Small Interfering; Sorafenib; Umbelliferones

2020
Proposal of a prediction model describing the metabolic interaction between warfarin and sorafenib using a population pharmacokinetic approach.
    International journal of clinical pharmacology and therapeutics, 2021, Volume: 59, Issue:3

    Topics: Anticoagulants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Genotype; Humans; International Normalized Ratio; Sorafenib; Vitamin K Epoxide Reductases; Warfarin

2021
A physiologically based pharmacokinetic/pharmacodynamic modeling approach for drug-drug interaction evaluation of warfarin enantiomers with sorafenib.
    Drug metabolism and pharmacokinetics, 2021, Volume: 39

    Topics: Anticoagulants; Blood Coagulation; Computer Simulation; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug; Drug Interactions; Hemorrhage; Humans; International Normalized Ratio; Models, Biological; Models, Theoretical; Pharmacogenomic Testing; Risk Assessment; Sorafenib; Vitamin K Epoxide Reductases; Warfarin

2021
Osthole Increases the Sensitivity of Liver Cancer to Sorafenib by Inhibiting Cholesterol Metabolism.
    Nutrition and cancer, 2022, Volume: 74, Issue:10

    Topics: Animals; Cholesterol; Coumarins; Liver; Liver Neoplasms; Mice; Sorafenib; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2

2022