Page last updated: 2024-09-05

sorafenib and ursodeoxycholic acid

sorafenib has been researched along with ursodeoxycholic acid in 3 studies

Compound Research Comparison

Studies (sorafenib)	Trials (sorafenib)	Recent Studies (post-2010) (sorafenib)	Studies (ursodeoxycholic acid)	Trials (ursodeoxycholic acid)	Recent Studies (post-2010) (ursodeoxycholic acid)
6,520	730	5,251	4,592	626	1,561

Protein Interaction Comparison

Protein	Taxonomy	ursodeoxycholic acid (IC50)
Bile salt export pump	Homo sapiens (human)	10
Sodium/bile acid cotransporter	Homo sapiens (human)	3.6
M1-family alanyl aminopeptidase	Plasmodium falciparum 3D7	2.6

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Cho, EJ; Cho, YY; Kim, YJ; Lee, JH; Lee, S; Yoon, JH; Yu, SJ	1

Reviews

1 review(s) available for sorafenib and ursodeoxycholic acid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

2 other study(ies) available for sorafenib and ursodeoxycholic acid

Article	Year
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Synergistic effect of ursodeoxycholic acid on the antitumor activity of sorafenib in hepatocellular carcinoma cells via modulation of STAT3 and ERK. International journal of molecular medicine, 2018, Volume: 42, Issue:5 Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Survival; Extracellular Signal-Regulated MAP Kinases; Hep G2 Cells; Humans; Liver Neoplasms; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Sorafenib; STAT3 Transcription Factor; Ursodeoxycholic Acid	2018

Article

Year

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012

Synergistic effect of ursodeoxycholic acid on the antitumor activity of sorafenib in hepatocellular carcinoma cells via modulation of STAT3 and ERK.

International journal of molecular medicine, 2018, Volume: 42, Issue:5

Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Survival; Extracellular Signal-Regulated MAP Kinases; Hep G2 Cells; Humans; Liver Neoplasms; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Sorafenib; STAT3 Transcription Factor; Ursodeoxycholic Acid

2018