Page last updated: 2024-09-05

sorafenib and tretinoin

sorafenib has been researched along with tretinoin in 12 studies

Compound Research Comparison

Studies
(sorafenib)
Trials
(sorafenib)
Recent Studies (post-2010)
(sorafenib)
Studies
(tretinoin)
Trials
(tretinoin)
Recent Studies (post-2010) (tretinoin)
6,5207305,25123,6541,0836,085

Protein Interaction Comparison

ProteinTaxonomysorafenib (IC50)tretinoin (IC50)
Bile salt export pumpHomo sapiens (human)10
Amyloid-beta precursor proteinHomo sapiens (human)0.18
Adenosine receptor A3Homo sapiens (human)5.275
Retinoic acid receptor alphaHomo sapiens (human)2.2542
60 kDa heat shock protein, mitochondrialHomo sapiens (human)5.3
Retinoic acid receptor betaHomo sapiens (human)0.7537
Retinoic acid receptor alphaMus musculus (house mouse)0.0057
Retinoic acid receptor gamma Homo sapiens (human)0.0064
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)5.275
Retinoic acid receptor gammaMus musculus (house mouse)0.004
Retinoic acid receptor betaMus musculus (house mouse)0.005
Mitogen-activated protein kinase 1Homo sapiens (human)0.576
Nuclear receptor ROR-alphaHomo sapiens (human)0.1995
Alpha-synucleinHomo sapiens (human)3
Cellular retinoic acid-binding protein 1Gallus gallus (chicken)0.5233
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.358
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)5.275
Retinoic acid receptor RXR-gammaHomo sapiens (human)0.35
Nuclear receptor ROR-gammaHomo sapiens (human)0.1995
10 kDa heat shock protein, mitochondrialHomo sapiens (human)5.3
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)0.82
60 kDa chaperonin Escherichia coli6.7
10 kDa chaperonin Escherichia coli6.7
Nuclear receptor ROR-betaHomo sapiens (human)0.1259

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (8.33)29.6817
2010's9 (75.00)24.3611
2020's2 (16.67)2.80

Authors

AuthorsStudies
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Evans, TR; Roxburgh, P1
Açmaz, G; Akkar, OB; Atilgan, R; Boztosun, A; Kosar, MI; Ozer, H1
He, XD; Liu, H; Qin, SK; Tao, L; Tong, XH; Wang, ZS; Wu, Q; Yang, Y; Zheng, RS1
Delabesse, E; Guenounou, S; Récher, C1
Ishijima, N; Kanki, K; Shimizu, H; Shiota, G1
Gabrilove, J; Jing, Y; Wang, R; Waxman, S; Xia, L1
Aplan, PD; Bruner, JK; Duffield, AS; Ghiaur, G; Greenblatt, SM; Jones, RJ; Jung, E; Li, L; Ma, HS; Nguyen, B; Shirley, CM; Small, D1
Bo, LS; Ke, WB; Li, T; Meng, YP; Zhang, Y1
Heo, J; Kim, AR; Kim, S; Lee, M; Lee, SY; Seo, HR; Shum, D; Song, Y1
Gao, F; He, H; Li, W; Lian, Z; Qiu, X; Su, R; Tan, Y; Wang, K; Xu, H; Xu, X; Zhang, Z; Zhuo, J1

Reviews

2 review(s) available for sorafenib and tretinoin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Systemic therapy of hepatocellular carcinoma: are we making progress?
    Advances in therapy, 2008, Volume: 25, Issue:11

    Topics: Antineoplastic Agents; Benzenesulfonates; Carcinoma, Hepatocellular; Catheter Ablation; Chemoembolization, Therapeutic; Estrogens; Humans; Injections, Intravenous; Interferons; Liver Neoplasms; Niacinamide; Palliative Care; Phenylurea Compounds; Pyridines; Risk Factors; Sorafenib; Tretinoin

2008

Other Studies

10 other study(ies) available for sorafenib and tretinoin

ArticleYear
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
The efficacy of bevacizumab, sorafenib, and retinoic acid on rat endometriosis model.
    Reproductive sciences (Thousand Oaks, Calif.), 2013, Volume: 20, Issue:1

    Topics: Administration, Oral; Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Disease Models, Animal; Endometriosis; Female; Microvessels; Niacinamide; Phenylurea Compounds; Random Allocation; Rats; Rats, Wistar; Sorafenib; Treatment Outcome; Tretinoin

2013
Connexin-dependent gap junction enhancement is involved in the synergistic effect of sorafenib and all-trans retinoic acid on HCC growth inhibition.
    Oncology reports, 2014, Volume: 31, Issue:2

    Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Communication; Cell Line, Tumor; Cell Proliferation; Connexins; Drug Synergism; Gap Junctions; Glycyrrhetinic Acid; Hep G2 Cells; Humans; Liver Neoplasms; Niacinamide; Oleic Acids; Phenylurea Compounds; Protein Kinase Inhibitors; Sorafenib; Tretinoin

2014
Sorafenib plus all-trans retinoic acid for AML patients with FLT3-ITD and NPM1 mutations.
    European journal of haematology, 2014, Volume: 93, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Fatal Outcome; Female; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mutation; Niacinamide; Nuclear Proteins; Nucleophosmin; Phenylurea Compounds; Sorafenib; Treatment Outcome; Tretinoin; Young Adult

2014
Activation of AMP-activated protein kinase by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib.
    Cancer science, 2015, Volume: 106, Issue:5

    Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Benzoates; Carcinoma, Hepatocellular; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; Humans; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Retinoids; Sorafenib; Tetrahydronaphthalenes; Tretinoin

2015
Sorafenib Inhibition of Mcl-1 Accelerates ATRA-Induced Apoptosis in Differentiation-Responsive AML Cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Mar-01, Volume: 22, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Differentiation; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Myeloid Cell Leukemia Sequence 1 Protein; Niacinamide; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Sorafenib; Tretinoin; Xenograft Model Antitumor Assays

2016
All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo.
    Blood, 2016, 06-09, Volume: 127, Issue:23

    Topics: Animals; Cell Death; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; fms-Like Tyrosine Kinase 3; Gene Duplication; Humans; Leukemia, Myeloid, Acute; Mice; Mutant Proteins; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Sorafenib; Tandem Repeat Sequences; Tretinoin; Xenograft Model Antitumor Assays

2016
miR-542-3p Appended Sorafenib/All-trans Retinoic Acid (ATRA)-Loaded Lipid Nanoparticles to Enhance the Anticancer Efficacy in Gastric Cancers.
    Pharmaceutical research, 2017, Volume: 34, Issue:12

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Mice, Nude; MicroRNAs; Nanoparticles; Niacinamide; Phenylurea Compounds; Sorafenib; Stomach Neoplasms; Tretinoin

2017
Identification of hepatic fibrosis inhibitors through morphometry analysis of a hepatic multicellular spheroids model.
    Scientific reports, 2021, 05-25, Volume: 11, Issue:1

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Colforsin; Drug Synergism; Epithelial-Mesenchymal Transition; Fibroblasts; Hep G2 Cells; Hepatic Stellate Cells; Human Umbilical Vein Endothelial Cells; Humans; Liver Cirrhosis; Liver Neoplasms; Small Molecule Libraries; Sorafenib; Spheroids, Cellular; Tretinoin; Tumor Microenvironment

2021
ATRA sensitized the response of hepatocellular carcinoma to Sorafenib by downregulation of p21-activated kinase 1.
    Cell communication and signaling : CCS, 2023, 08-03, Volume: 21, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Humans; Liver Neoplasms; p21-Activated Kinases; Sorafenib; Tretinoin

2023