Compounds > sorafenib

Page last updated: 2024-09-05

sorafenib and sb-590885

sorafenib has been researched along with sb-590885 in 7 studies

Compound Research Comparison

Studies (sorafenib)	Trials (sorafenib)	Recent Studies (post-2010) (sorafenib)	Studies (sb-590885)	Trials (sb-590885)	Recent Studies (post-2010) (sb-590885)
6,520	730	5,251	17	0	11
6,520	730	5,251	9	0	6
6,520	730	5,251	10	0	8

Protein Interaction Comparison

Protein	Taxonomy	sorafenib (IC50)	sb-590885 (IC50)
Serine/threonine-protein kinase B-raf	Homo sapiens (human)		0.1934

Research

Studies (7)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (28.57)	29.6817
2010's	5 (71.43)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Batt, D; Li, N; Warmuth, M	1
Berger, DM; Collins, K; Frommer, E; Hu, Y; Powell, D; Salaski, EJ; Wang, X; Wojciechowicz, D	1
Luo, C; Marmorstein, R; Xie, P	1
Gong, HB; Li, CY; Li, QS; Sun, XG; Wei, R; Yan, L; Zhu, HL	1
Kim, J; Wang, X	1
Agianian, B; Gavathiotis, E	1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ	1

Reviews

2 review(s) available for sorafenib and sb-590885

Article	Year
B-Raf kinase inhibitors for cancer treatment. Current opinion in investigational drugs (London, England : 2000), 2007, Volume: 8, Issue:6 Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Enzyme Inhibitors; Humans; Imidazoles; Neoplasms; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins B-raf; Pyridines; Sorafenib	2007
Current Insights of BRAF Inhibitors in Cancer. Journal of medicinal chemistry, 2018, 07-26, Volume: 61, Issue:14 Topics: Animals; Drug Discovery; Humans; Mutation; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf	2018

Other Studies

5 other study(ies) available for sorafenib and sb-590885

Article	Year
Structure-based design of isoindoline-1,3-diones and 2,3-dihydrophthalazine-1,4-diones as novel B-Raf inhibitors. Bioorganic & medicinal chemistry letters, 2011, Dec-01, Volume: 21, Issue:23 Topics: Benzenesulfonates; Drug Design; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Isoindoles; Models, Molecular; Molecular Structure; Niacinamide; Phenylurea Compounds; Phthalazines; Proto-Oncogene Proteins B-raf; Pyridines; Sorafenib; Structure-Activity Relationship	2011
Identification of BRAF inhibitors through in silico screening. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Algorithms; Binding Sites; Cloning, Molecular; Computer Simulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Chemical; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Sensitivity and Specificity; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship	2008
Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors. Bioorganic & medicinal chemistry, 2012, Jun-15, Volume: 20, Issue:12 Topics: Animals; Cell Proliferation; Drug Design; Humans; Mice; Models, Molecular; Niacinamide; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Quantitative Structure-Activity Relationship; Rats; Tumor Cells, Cultured	2012
Conformation-specific effects of Raf kinase inhibitors. Journal of medicinal chemistry, 2012, Sep-13, Volume: 55, Issue:17 Topics: Dimerization; Models, Molecular; Protein Conformation; Protein Kinase Inhibitors; raf Kinases	2012
Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15 Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship	2013