Compounds > sorafenib
Page last updated: 2024-09-05

sorafenib and quinacrine

sorafenib has been researched along with quinacrine in 4 studies

Compound Research Comparison

Studies
(sorafenib)		Trials
(sorafenib)		Recent Studies (post-2010)
(sorafenib)		Studies
(quinacrine)		Trials
(quinacrine)		Recent Studies (post-2010) (quinacrine)
6,5207305,2514,05165289

Protein Interaction Comparison

ProteinTaxonomysorafenib (IC50)quinacrine (IC50)
cystic fibrosis transmembrane conductance regulatorHomo sapiens (human)19.88
Major prion proteinMus musculus (house mouse)0.0951
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.896
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.964
Muscarinic acetylcholine receptor M4Homo sapiens (human)1.983
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)4.5
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)4.5
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)4.5
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)4.5
Muscarinic acetylcholine receptor M5Homo sapiens (human)3.736
Alpha-2A adrenergic receptorHomo sapiens (human)2.28
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)4.5
Muscarinic acetylcholine receptor M1Homo sapiens (human)1.489
Alpha-2B adrenergic receptorHomo sapiens (human)1.825
Alpha-2C adrenergic receptorHomo sapiens (human)3.857
Muscarinic acetylcholine receptor M3Homo sapiens (human)1.255
AcetylcholinesteraseHomo sapiens (human)2.667
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.896
Histamine H2 receptorHomo sapiens (human)3.535
Alpha-1D adrenergic receptorHomo sapiens (human)2.065
5-hydroxytryptamine receptor 2AHomo sapiens (human)2.663
D(3) dopamine receptorHomo sapiens (human)1.318
Aldehyde oxidase 1Oryctolagus cuniculus (rabbit)10
CholinesteraseEquus caballus (horse)4.5
Aldehyde oxidaseHomo sapiens (human)3.3
Cyclic GMP-AMP synthaseHomo sapiens (human)7

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Abdulghani, J; Allen, JE; Dicker, DT; Dolloff, NG; El-Deiry, WS; Gallant, JN; Hong, B; Katz, SI; Navaraj, A; Smith, CD; Wang, W1
Allen, JE; Dicker, DT; Dolloff, NG; El-Deiry, WS; Gallant, JN; Navaraj, A; Smith, CD; Wang, W1
Abdulghani, J; Cooper, T; Derr, J; Dicker, D; El-Deiry, WS; Finnberg, NK; Gallant, JN; Gokare, P; Goldenberg, D; Liao, J; Liu, J; Whitcomb, T1

Other Studies

4 other study(ies) available for sorafenib and quinacrine

ArticleYear
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents.
    Cancer biology & therapy, 2011, Aug-01, Volume: 12, Issue:3

    Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Camptothecin; Carcinoma, Hepatocellular; Cell Death; Cell Nucleus; Cytoplasm; Deoxycytidine; Doxorubicin; Drug Synergism; Etoposide; Female; Fluorouracil; Gemcitabine; Genes, p53; Humans; Irinotecan; Liver Neoplasms; Mice; Microtubule-Associated Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins c-bcl-2; Pyridines; Quinacrine; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Small Interfering; Sorafenib; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2011
Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer.
    Cancer biology & therapy, 2011, Aug-01, Volume: 12, Issue:3

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Drug Synergism; Female; Fluorouracil; Humans; Mice; Mice, Nude; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; NF-kappa B; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins p21(ras); Pyridines; Quinacrine; ras Proteins; Sorafenib; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2011
Sorafenib and Quinacrine Target Anti-Apoptotic Protein MCL1: A Poor Prognostic Marker in Anaplastic Thyroid Cancer (ATC).
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Dec-15, Volume: 22, Issue:24

    Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Synergism; Humans; Mice; Mice, Inbred C57BL; Myeloid Cell Leukemia Sequence 1 Protein; NF-kappa B; Niacinamide; Phenylurea Compounds; Prognosis; Protein Kinase Inhibitors; Quinacrine; Sorafenib; Thyroid Carcinoma, Anaplastic; Thyroid Gland; Thyroid Neoplasms; Transcription Factor RelA

2016