Page last updated: 2024-09-05

sorafenib and quercetin

sorafenib has been researched along with quercetin in 10 studies

Compound Research Comparison

Studies
(sorafenib)
Trials
(sorafenib)
Recent Studies (post-2010)
(sorafenib)
Studies
(quercetin)
Trials
(quercetin)
Recent Studies (post-2010) (quercetin)
6,5207305,25112,4032397,510

Protein Interaction Comparison

ProteinTaxonomysorafenib (IC50)quercetin (IC50)
Neuraminidase Influenza A virus (A/Wilson-Smith/1933(H1N1))2.2
hexokinaseTrypanosoma brucei brucei TREU92722.378
Maltase-glucoamylase, intestinalHomo sapiens (human)7.8
NUAK family SNF1-like kinase 1Homo sapiens (human)5.09
Lysine-specific histone demethylase 1AHomo sapiens (human)1.26
B2 bradykinin receptorCavia porcellus (domestic guinea pig)4
Arginase Leishmania amazonensis4
Epidermal growth factor receptorHomo sapiens (human)0.9
ProthrombinHomo sapiens (human)1.5
Cationic trypsinBos taurus (cattle)7.1
Beta-lactamaseEscherichia coli K-124
NeuraminidaseInfluenza A virus (A/Puerto Rico/8/1934(H1N1))7.75
Interstitial collagenaseHomo sapiens (human)1.49
Phospholipase A2Homo sapiens (human)2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Oryctolagus cuniculus (rabbit)9
Cytochrome P450 1A1Homo sapiens (human)5.5455
Amyloid-beta precursor proteinHomo sapiens (human)7.94
MyeloperoxidaseHomo sapiens (human)1.6975
Cytochrome P450 1A2Homo sapiens (human)4.097
Cyclin-dependent kinase 1Homo sapiens (human)0.45
Glycogen phosphorylase, liver formHomo sapiens (human)4.8
Epoxide hydrolase 1 Homo sapiens (human)7
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)6.6417
Insulin-like growth factor 1 receptorHomo sapiens (human)0.3
Neutrophil elastaseHomo sapiens (human)22.378
72 kDa type IV collagenaseHomo sapiens (human)6.68
Stromelysin-1Homo sapiens (human)5.57
Hepatocyte growth factor receptorHomo sapiens (human)0.58
Cytochrome P450 3A4Homo sapiens (human)7
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)2.6975
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus8.1
Lysosomal alpha-glucosidaseHomo sapiens (human)7.8
SialidaseClostridium perfringens4.7333
Malate dehydrogenaseThermus thermophilus6
Cytochrome P450 2C8Homo sapiens (human)7
Serine/threonine-protein kinase pim-1Homo sapiens (human)0.7686
AromataseHomo sapiens (human)0.012
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)1.95
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)0.43
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.12
Sucrase-isomaltase, intestinalHomo sapiens (human)7.8
Matrix metalloproteinase-9Homo sapiens (human)0.8919
Serine/threonine-protein kinase B-rafHomo sapiens (human)7.589
Aldo-keto reductase family 1 member B1Homo sapiens (human)2.2141
G2/mitotic-specific cyclin-BMarthasterias glacialis (spiny starfish)2.1
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)2.2
Aldo-keto reductase family 1 member B1Bos taurus (cattle)2.85
Polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)0.44
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)2.1
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)4
Casein kinase II subunit alpha'Homo sapiens (human)1.65
Amine oxidase [flavin-containing] AHomo sapiens (human)2.62
Amine oxidase [flavin-containing] A Bos taurus (cattle)0.01
C-X-C chemokine receptor type 1Homo sapiens (human)4.7559
Dipeptidyl peptidase 4Homo sapiens (human)2.92
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)3.8
Proteasome subunit beta type-5Homo sapiens (human)2.75
Vasopressin V2 receptorHomo sapiens (human)6.6548
Tyrosine-protein kinase receptor UFOHomo sapiens (human)0.96
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)1
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)5.39
Bifunctional epoxide hydrolase 2Homo sapiens (human)7
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.97
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.59
17-beta-hydroxysteroid dehydrogenase type 2Homo sapiens (human)1.54
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)1
Collagenase 3Homo sapiens (human)8.46
1-deoxy-D-xylulose 5-phosphate reductoisomeraseEscherichia coli K-121.9
Xanthine dehydrogenase/oxidaseHomo sapiens (human)3.04
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)3.8
Glycogen synthase kinase-3 alphaHomo sapiens (human)2.1
Glycogen synthase kinase-3 betaHomo sapiens (human)2.1
Aldo-keto reductase family 1 member A1Rattus norvegicus (Norway rat)2.32
C-C chemokine receptor type 4Homo sapiens (human)10
Serine/threonine-protein kinase Nek2Homo sapiens (human)5.73
Serine/threonine-protein kinase PLK1Homo sapiens (human)5.75
Death-associated protein kinase 1Homo sapiens (human)8.9
Mitogen-activated protein kinase 10Homo sapiens (human)2.88
Beta-secretase 1Homo sapiens (human)6.05
Casein kinase II subunit betaHomo sapiens (human)1.65
Casein kinase II subunit alphaHomo sapiens (human)1.65
LactoperoxidaseBos taurus (cattle)6.1
Cyclin-dependent kinase 6Homo sapiens (human)2.1
Cyclin-dependent-like kinase 5 Homo sapiens (human)2.1
Cyclin homologHerpesvirus saimiri (strain 11)2.1
Lactoylglutathione lyaseHomo sapiens (human)3.2
Focal adhesion kinase 1Homo sapiens (human)1.2
Calcium/calmodulin-dependent protein kinase type II subunit betaHomo sapiens (human)3
ELAV-like protein 3Homo sapiens (human)1.8
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)2.1
ELAV-like protein 1Homo sapiens (human)1.4
Serine/threonine-protein kinase N1Homo sapiens (human)5.8
Mitogen-activated protein kinase 14Homo sapiens (human)2.88
Cytochrome P450 1B1Homo sapiens (human)1.1108
Probable maltase-glucoamylase 2Homo sapiens (human)7.8
Monocarboxylate transporter 2Rattus norvegicus (Norway rat)5
Integrase Human immunodeficiency virus 14.3
Casein kinase II subunit alpha 3Homo sapiens (human)0.55
Inositol polyphosphate multikinaseHomo sapiens (human)2.3
Aldo-keto reductase family 1 member C21Mus musculus (house mouse)6.9
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)1.8333
3-oxoacyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)5.4
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)Plasmodium falciparum (malaria parasite P. falciparum)1.5
Aurora kinase BHomo sapiens (human)2.435
Cyclin-dependent kinase 1Oryzias latipes (Japanese medaka)2.1
Serine/threonine-protein kinase Nek6Homo sapiens (human)4.23
NADPH oxidase 4Homo sapiens (human)0.68
Inositol hexakisphosphate kinase 2Homo sapiens (human)0.7
Short transient receptor potential channel 5Homo sapiens (human)6.5
ALK tyrosine kinase receptorHomo sapiens (human)3.32
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)7.25

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (60.00)24.3611
2020's4 (40.00)2.80

Authors

AuthorsStudies
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Bądziul, D; Jakubowicz-Gil, J; Langner, E; Rzeski, W; Wertel, I1
Rupasinghe, HV; Sudan, S1
Abrantes, AM; Botelho, MF; Brito, AF; Casalta-Lopes, JE; Gonçalves, AC; Laranjo, M; Mamede, AC; Ribeiro, M; Sarmento-Ribeiro, AB; Tralhão, JG1
Cao, Y; Feng, F; Hou, MX; Jia, H; Jiang, QY; Ma, HD; Sun, HW; Wang, T; Yang, Q; Yang, YP1
Abballe, L; Allegri, L; Bulotta, S; Celano, M; Damante, G; Maggisano, V; Pecce, V; Russo, D1
Alsaif, NA; Bakheit, AH; Wani, TA; Zargar, S1
Cao, S; Feng, F; Jia, H; Jiang, Q; Li, B; Lu, J; Wei, L; Zhang, Y1
Abdu, S; Amin, A; Juaid, N; Miled, N; Moulay, M1

Other Studies

10 other study(ies) available for sorafenib and quercetin

ArticleYear
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Quercetin and sorafenib as a novel and effective couple in programmed cell death induction in human gliomas.
    Neurotoxicity research, 2014, Volume: 26, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Astrocytoma; Autophagy; Cell Line, Tumor; Drug Therapy, Combination; Glioblastoma; Glioma; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Humans; Membrane Potential, Mitochondrial; Mitochondria; Molecular Chaperones; Necrosis; Niacinamide; Phenylurea Compounds; Quercetin; Sorafenib

2014
Antiproliferative activity of long chain acylated esters of quercetin-3-O-glucoside in hepatocellular carcinoma HepG2 cells.
    Experimental biology and medicine (Maywood, N.J.), 2015, Volume: 240, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Cycle; Cell Proliferation; Cisplatin; DNA Fragmentation; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Esters; Fatty Acids; Flavonoids; Glucosides; Hep G2 Cells; Humans; Liver Neoplasms; Microscopy, Fluorescence; Niacinamide; Phenylurea Compounds; Quercetin; Sorafenib

2015
New Approach for Treatment of Primary Liver Tumors: The Role of Quercetin.
    Nutrition and cancer, 2016, Volume: 68, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Survival; DNA Damage; Fluorodeoxyglucose F18; Glucose Transporter Type 1; Hep G2 Cells; Humans; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins c-bcl-2; Quercetin; Sorafenib; Tumor Suppressor Protein p53

2016
Rhamnetin induces sensitization of hepatocellular carcinoma cells to a small molecular kinase inhibitor or chemotherapeutic agents.
    Biochimica et biophysica acta, 2016, Volume: 1860, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; Male; Mice, SCID; MicroRNAs; Niacinamide; Paclitaxel; Phenylurea Compounds; Protein Kinase Inhibitors; Quercetin; Receptor, Notch1; Signal Transduction; Sorafenib; Transfection; Xenograft Model Antitumor Assays

2016
Quercetin improves the effects of sorafenib on growth and migration of thyroid cancer cells.
    Endocrine, 2020, Volume: 67, Issue:2

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Niacinamide; Phenylurea Compounds; Quercetin; Sorafenib; Thyroid Neoplasms

2020
Multi-spectroscopic investigation, molecular docking and molecular dynamic simulation of competitive interactions between flavonoids (quercetin and rutin) and sorafenib for binding to human serum albumin.
    International journal of biological macromolecules, 2020, Dec-15, Volume: 165, Issue:Pt B

    Topics: Binding Sites; Circular Dichroism; Humans; Kinetics; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Quercetin; Rutin; Serum Albumin, Human; Sorafenib; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Thermodynamics

2020
Rhamnetin decelerates the elimination and enhances the antitumor effect of the molecular-targeting agent sorafenib in hepatocellular carcinoma cells via the miR-148a/PXR axis.
    Food & function, 2021, Mar-21, Volume: 12, Issue:6

    Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Interactions; Drug Resistance, Neoplasm; Liver; Liver Neoplasms; Mice; Mice, Nude; MicroRNAs; Pregnane X Receptor; Quercetin; Sorafenib

2021
Effects of Sorafenib and Quercetin Alone or in Combination in Treating Hepatocellular Carcinoma: In Vitro and In Vivo Approaches.
    Molecules (Basel, Switzerland), 2022, Nov-21, Volume: 27, Issue:22

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Quercetin; Sorafenib; Xenograft Model Antitumor Assays

2022