Page last updated: 2024-09-05

sorafenib and pirfenidone

sorafenib has been researched along with pirfenidone in 2 studies

Compound Research Comparison

Studies (sorafenib)	Trials (sorafenib)	Recent Studies (post-2010) (sorafenib)	Studies (pirfenidone)	Trials (pirfenidone)	Recent Studies (post-2010) (pirfenidone)
6,520	730	5,251	1,094	102	883

Protein Interaction Comparison

Protein	Taxonomy	sorafenib (IC50)	pirfenidone (IC50)
Transforming growth factor beta-1 proprotein	Mus musculus (house mouse)		1.43
Mothers against decapentaplegic homolog 3	Mus musculus (house mouse)		1.43

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	1 (50.00)	2.80

Authors

Authors	Studies
Groothuis, GM; Olinga, P; Oosterhuis, D; Westra, IM	1
Cai, M; Chen, J; Chen, Y; Guo, Y; Huang, J; Huang, W; Lai, M; Liang, L; Lin, L; Liu, M; Xie, L; Zhang, X; Zhang, Y; Zhu, K	1

Other Studies

2 other study(ies) available for sorafenib and pirfenidone

Article	Year
Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs. Toxicology and applied pharmacology, 2014, Jan-15, Volume: 274, Issue:2 Topics: Animals; Becaplermin; Benzamides; Benzylisoquinolines; Cinnamates; Collagen Type I; Connective Tissue Growth Factor; Depsides; Down-Regulation; Gene Expression; HSP47 Heat-Shock Proteins; Imatinib Mesylate; Liver; Liver Cirrhosis; Male; Models, Biological; Niacinamide; Organ Culture Techniques; Perindopril; Phenylurea Compounds; Piperazines; Proto-Oncogene Proteins c-sis; Pyridones; Pyrimidines; Rats; Rats, Wistar; Rosmarinic Acid; Sorafenib; Transforming Growth Factor beta1; Valproic Acid	2014
Inhibition of CEMIP potentiates the effect of sorafenib on metastatic hepatocellular carcinoma by reducing the stiffness of lung metastases. Cell death & disease, 2023, 01-13, Volume: 14, Issue:1 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; Hyaluronoglucosaminidase; Liver Neoplasms; Lung Neoplasms; Signal Transduction; Sorafenib; Tumor Microenvironment	2023

Article

Year

Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.

Toxicology and applied pharmacology, 2014, Jan-15, Volume: 274, Issue:2

Topics: Animals; Becaplermin; Benzamides; Benzylisoquinolines; Cinnamates; Collagen Type I; Connective Tissue Growth Factor; Depsides; Down-Regulation; Gene Expression; HSP47 Heat-Shock Proteins; Imatinib Mesylate; Liver; Liver Cirrhosis; Male; Models, Biological; Niacinamide; Organ Culture Techniques; Perindopril; Phenylurea Compounds; Piperazines; Proto-Oncogene Proteins c-sis; Pyridones; Pyrimidines; Rats; Rats, Wistar; Rosmarinic Acid; Sorafenib; Transforming Growth Factor beta1; Valproic Acid

2014

Inhibition of CEMIP potentiates the effect of sorafenib on metastatic hepatocellular carcinoma by reducing the stiffness of lung metastases.

Cell death & disease, 2023, 01-13, Volume: 14, Issue:1

Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; Hyaluronoglucosaminidase; Liver Neoplasms; Lung Neoplasms; Signal Transduction; Sorafenib; Tumor Microenvironment

2023