Page last updated: 2024-09-05

sorafenib and nvp-aew541

sorafenib has been researched along with nvp-aew541 in 3 studies

Compound Research Comparison

Studies
(sorafenib)
Trials
(sorafenib)
Recent Studies (post-2010)
(sorafenib)
Studies
(nvp-aew541)
Trials
(nvp-aew541)
Recent Studies (post-2010) (nvp-aew541)
6,5207305,25195061

Protein Interaction Comparison

ProteinTaxonomysorafenib (IC50)nvp-aew541 (IC50)
3-phosphoinositide-dependent protein kinase 1Homo sapiens (human)8.9
Epidermal growth factor receptorHomo sapiens (human)5.2
Insulin receptorHomo sapiens (human)0.7885
Tyrosine-protein kinase LckHomo sapiens (human)5.6
Tyrosine-protein kinase LynHomo sapiens (human)1.4
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)3.3
Insulin-like growth factor 1 receptorHomo sapiens (human)0.0534
Mast/stem cell growth factor receptor KitHomo sapiens (human)6.3
Fibroblast growth factor receptor 1Homo sapiens (human)4.3
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)4
Platelet-derived growth factor receptor alphaHomo sapiens (human)0.8
Fibroblast growth factor receptor 2Homo sapiens (human)2.7
Fibroblast growth factor receptor 4Homo sapiens (human)5
Vascular endothelial growth factor receptor 2Homo sapiens (human)7.1
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)1.4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)3.2
Activin receptor type-1Homo sapiens (human)2.9
Tyrosine-protein kinase BTKHomo sapiens (human)7.6
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.13
Receptor tyrosine-protein kinase erbB-4Homo sapiens (human)1.7

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bellail, AC; Ding, L; Hao, C; Liu, Y; Lu, G; Olson, JJ; Sun, SY; Wang, G; Wei, F; Yuan, C1
Chang, YC; Cheng, AL; Hsu, C; Lee, BS; Lin, LI; Liou, JY; Ou, DL1
Alonso, V; Asensio, E; Camps, J; Castells, A; Codony-Servat, J; Cuatrecasas, M; Escudero, P; Feliu, J; Fernández-Martos, C; Gaba, L; Gallego, J; García-Albéniz, X; Horndler, C; Jares, P; Marín-Aguilera, M; Martín-Richard, M; Martínez-Balibrea, E; Martínez-Cardús, A; Maurel, J; Méndez, JC; Méndez, M; Montironi, C; Prat, A; Reig, O; Rojo, F; Rosell, R; Rubini, M; Salud, A; Victoria, I1

Other Studies

3 other study(ies) available for sorafenib and nvp-aew541

ArticleYear
K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic ductal adenocarcinomas.
    Cancer letters, 2012, Sep-01, Volume: 322, Issue:1

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Activation; Everolimus; Extracellular Signal-Regulated MAP Kinases; Feedback, Physiological; Female; Humans; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mechanistic Target of Rapamycin Complex 1; Mice; Multiprotein Complexes; Mutation; Niacinamide; Pancreatic Neoplasms; Phenylurea Compounds; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyridines; Pyrimidines; Pyrroles; ras Proteins; Sirolimus; Sorafenib; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

2012
Potentiating the efficacy of molecular targeted therapy for hepatocellular carcinoma by inhibiting the insulin-like growth factor pathway.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cells, Cultured; Checkpoint Kinase 2; Drug Resistance, Neoplasm; Drug Synergism; Humans; Indoles; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Niacinamide; Phenylurea Compounds; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor, IGF Type 1; RNA Interference; Signal Transduction; Sorafenib; Sunitinib; Xenograft Model Antitumor Assays

2013
Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer.
    British journal of cancer, 2017, Dec-05, Volume: 117, Issue:12

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cell Nucleus; Cell Survival; Cetuximab; Colorectal Neoplasms; Curcumin; Dasatinib; Drug Resistance, Neoplasm; Fatty Acids, Unsaturated; Female; Fluorouracil; Gene Silencing; HCT116 Cells; HT29 Cells; Humans; Leucovorin; Male; Middle Aged; Molecular Chaperones; Molecular Targeted Therapy; Niacinamide; Organoplatinum Compounds; Oxaliplatin; Panitumumab; Phenylurea Compounds; Protein Inhibitors of Activated STAT; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Pyrimidines; Pyrroles; Receptor, IGF Type 1; Signal Transduction; Sorafenib

2017